@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu31740: (2016-07-22 )
MRVFVARQPIFNRKEQVVAYELLYRESEENVYSAKDGDQATTDLVINSFLNIGIEKLTEGKRCFVNFTESLMFSNLPTSFNPKQLVIEILEDIPITPALISRCKELKKMGYMLALDDFYAINPQDEDLLEKLMSYIDILKIDFLKTTRMERRTILQTYGCRGLIFLAEKVETRKEYKQAVQDGFQLFQGYFFSEPRIISGHDLSTHFYSYYELLNELSKEQPNIKRVTEYIERDLSLSYQILKFLNSSHSRLSQKIESIQQAIMLLGFNEIKRWIYILSFKDLSRKGHSSKHEIIKISLIRAKLCELLARKTSRPQPASYMLIGMFSLIDTLLHREIEEIVQELPLKDEVGQALLGHQNDYYQMLELVKLIESNNWDTCSELGNQLDKEEAYECYLEALEWCHNLMDAK
Atome Classification :
(20 SA)
----------------------------------------------.........10..-..-.-.---------..20......-..-30.-.--..---------.------.------...40.--....---...50......--.----.60....----------------------....70.-..---.--..----------..80........90..--.-------.-....100-.......110.......120.--......130...-..---------..140--..--------.--.-------...--------150.......160.....--..170..-.....180.......190...------------....200.......210..--.....220.......230......----------.240.......250.......260--------..-.....270....-----..-.280.-...-.--..----290.......300......---------.-310.------....-.-.320.......330-------..------....--------------------------------.-----------------------------------..340...--....-350......-...--------360-------......--...370--...------..-..380..--.....----390.......400.......------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------------
M
R
V
F
V
ARQPIFNR-
K
E
-
Q
-
V
---------
V
A
Y
E
L
L
YRES-EE-N-V-Y--SA---------K------D------GD
Q
A
T
T
--
D
L
V
I
---
N
S
F
L
N
I
G
I
E
K
L--T----EG
K
R
C
F
V
----------------------
N
F
T
E
S
L
M
-FS---N--LP----------TSF
N
P
K
Q
L
V
I
E
I
L
E
DI--P-------I-
T
P
A
L
I
S
R
-
C
K
E
L
K
KMG
Y
M
L
A
LD
D
F
Y
AINP--Q
D
E
D
L
L
E
K
L
M
S
Y
-
I
D
---------
I
L
K
I
D
--
F
L
--------
K
--T-------
T
R
M
--------
E
R
R
T
I
L
Q
T
YGCR
G
L
I
F
L
A
--
E
K
V
E
T
R
K
-
E
Y
K
Q
A
V
Q
D
G
F
Q
L
F
Q
G
YFFSE
P
------------
R
I
ISGHD
L
S
T
H
F
Y
S
Y
Y
E
L
L
--
N
E
L
S
KEQP
N
I
K
R
V
T
E
Y
I
E
R
D
L
S
L
S
----------
Y
Q
I
L
K
F
L
N
S
S
H
S
R
L
S
Q
K
I
E
S
I
Q
Q
A
--------
I
M
-
L
L
G
F
N
E
I
K
R
W
I
Y
-----
I
L
-
S
F
K
D
L
-SRK-G--HS----SK
H
E
I
I
K
I
S
L
I
R
A
K
L
C
E
L
L
---------
A
-
R
KTS------RPQP-
A
-
S
Y
M
L
I
G
M
F
S
L
I
D
---------
T
L
------
L
H
R
E
--------------------------------
I
-----------------------------------
E
E
I
V
Q
ELP--
L
K
D
E
-
V
--
G
Q
A
L
LG-HQ
N
--------
D
---------
Y
Y
Q
M
L
E
--
L
V
K
L
I
E--SNN------W
D
-
T
C
S
E
L
G
N
--QL
D
K
E
----
E
A
Y
E
C
Y
L
E
A
L
E
W
C
H
N
LMDAK------------------------
37
HHSearch
55.34
20%
-62
- C3 -
3SY8
1
?
A:
[155-383]
-----------------------------------------------
E
F
E
A
Y
Y
Q
P
K
V
A
L
D
G
G
-
G
-
L
---------
I
G
A
E
V
L
A
R
W
N
H
P
H
-
L
-
G
-
V
LP
P
S
HF
L
------
Y
V
M
E
T
Y
N
L
------
V
D
K
L
F
W
--
Q
L
F
S
---
Q
G
L
A
T
R
R
K
L
A
Q
L
-
G
----
Q
P
I
N
L
A
F
----------------------
N
V
H
P
S
Q
L
-
G
S
---
R
--
A
L
A
E
N
I
S
A
L
L
T
E
F
H
L
P
P
S
S
V
M
F
E
I
T
E
T
G
L
I
S
-------
A
-
P
A
S
S
L
E
N
-
L
V
R
L
W
I
M
G
C
G
L
A
M
D
D
F
G
A
-
G
Y
--
S
S
---
L
D
R
L
C
E
F
P
F
S
---------
Q
I
K
L
D
--
R
T
--------
F
--
V
-------
Q
K
M
KTQ
P
R
S
C
A
V
I
S
S
V
V
A
L
A
Q
A
L
G
I
S
L
V
V
--
E
G
V
E
S
D
E
-
Q
R
V
R
L
I
E
L
G
C
S
I
A
Q
G
Y
L
F
A
R
P
------------
M
P
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
54.84
22%
-55
- C3 -
4HU4
-
DOSP_ECOLI
A:
[556-785]
-----------------------------------------------
Q
L
K
L
V
Y
Q
P
Q
I
F
A
E
T
G
-
E
-
L
---------
Y
G
I
E
A
L
A
R
W
H
D
P
L
-
H
G
H
-
V
P-
P
S
RFI------
P
------
L
AEEIGE
I
E
N
I
G
R
--
W
V
I
A
---
E
A
C
R
Q
L
A
E
W
R
S
--
Q
NI--
H
I
P
A
L
S
V
----------------------
N
L
S
A
L
H
F
-
R
S
---
N
--
Q
L
P
N
Q
V
S
D
A
M
H
A
W
G
I
D
G
H
Q
L
T
V
E
I
T
E
S
M
--
M
ME-----
H
-
D
T
E
I
F
K
R
-
I
Q
I
L
R
D
M
G
V
G
L
S
V
D
D
F
G
-----------------
L
P
V
T
---------
E
I
K
I
D
--
K
S
--------
F
--
V
-------
D
R
C
L
T
E
K
R
I
L
A
L
L
E
A
I
T
S
I
G
Q
S
L
N
L
T
V
V
A
--
E
G
V
E
T
K
E
-
Q
F
E
M
L
R
K
I
H
C
R
V
I
Q
G
Y
F
F
S
R
P
------------
L
P
A
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
54.82
23%
-22
- C3 -
4RNI
-
?
A:
[19-247]
-----------------------------------------------
E
F
V
L
H
Y
Q
P
Q
F
T
G
D
G
R
-
R
-
L
---------
T
G
A
E
A
L
L
R
W
Q
H
P
R
-
R
-
G
L
V
P-
P
S
E
F
I
------
P
------
V
L
E
E
I
GL
V
A
Q
V
G
D
--
W
L
L
A
---
E
A
C
K
Q
L
R
S
W
H
K
A
K
V
----
R
V
P
K
V
S
V
----------------------
N
L
S
A
R
Q
F
-
A
D
---
G
--
Q
L
G
E
R
I
A
A
I
L
Y
E
T
G
I
P
P
A
C
L
E
L
E
L
T
E
S
I
L
M
S
-------
D
-
V
A
E
A
M
Q
I
-
L
S
G
L
K
R
L
G
L
A
I
A
V
D
D
F
G
T
-
G
Y
--
S
S
---
L
N
Y
L
K
Q
F
P
I
D
---------
V
L
K
I
D
--
R
S
--------
F
--
V
-------
D
G
L
PHG
E
Q
D
A
Q
I
A
R
A
I
I
A
M
A
H
S
L
N
L
M
V
I
A
--
E
G
V
E
S
Q
A
-
Q
L
D
F
L
R
E
H
G
C
D
E
V
Q
G
Y
L
F
G
R
P
------------
M
P
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
54.72
17%
-127
- C4 -
3HC1
7
?
A:
[23-242]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
E
L
P
T
V
P
D
I
V
L
R
I
A
--
G
K
L
N
D
P
D
V
A
I
D
E
V
A
D
L
L
L
Q
D
Q
V
L
T
----------
A
R
V
V
H
L
A
N
S
P
L
Y
S
A
A
R
P
I
S
S
I
R
D
A
--------
V
I
-
Y
L
G
L
D
L
L
R
E
A
I
F
-----
T
C
-
A
I
V
D
L
F
K
T
G
-
K
G-
P
L
----
N
R
S
T
L
W
A
H
S
L
G
V
A
R
I
A
K
L
I
---------
A
-
E
R
T
G
------
F
L
N
P
-
V
-
N
V
Y
V
A
G
L
L
H
D
V
G
---------
E
V
------
F
I
N
F
--------------------------------
F
R
G
K
E
F
S
Q
V
V
T
L
V
D
E
EKIT
F
G
Q
A
E
E
R
L
FGTS
H
C
E
V
G
F
A
L
A
K
R
W
S
--
L
N
E
F
-
I
--
C
D
T
I
L
Y
-
H
H
D
--------
I
EAVPYKQA
A
I
V
A
M
V
A
--
F
A
D
E
Y
C
--
T
-------------------------------------------------------------------------
41
HHSearch
53.89
23%
-14
- C3 -
4RNH
3
?
A:
[213-442]
-----------------------------------------------
E
F
V
L
H
Y
Q
P
Q
F
T
G
D
G
R
-
R
-
L
---------
T
G
A
E
A
L
L
R
W
Q
H
P
R
-
R
G
L
-
V
P-
P
S
EF
I
------
P
------
V
L
E
E
I
GL
V
A
Q
V
G
D
--
W
L
L
A
---
E
A
C
K
Q
L
R
S
W
H
K
--
A
KV--
R
V
P
K
V
S
V
----------------------
N
L
S
A
R
Q
F
-
A
D
---
G
--
Q
L
G
E
R
I
A
A
I
L
Y
E
T
G
I
P
P
A
C
L
E
L
E
L
T
E
S
I
L
M
S
-------
D
-
V
A
E
A
M
Q
I
-
L
S
G
L
K
R
L
G
L
A
I
A
V
D
D
F
G
T
-
G
Y
--
S
S
---
L
N
Y
L
K
Q
F
P
I
D
---------
V
L
K
I
D
--
R
S
--------
F
--
V
-------
D
G
L
PHG
E
Q
D
A
Q
I
A
R
A
I
I
A
M
A
H
S
L
N
L
M
V
I
A
--
E
G
V
E
S
Q
A
-
Q
L
D
F
L
R
E
H
G
C
D
E
V
Q
G
Y
L
F
G
R
P
------------
M
P
A
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
53.22
22%
-29
- C3 -
4KIE
5
YAHA_ECOLI
A:
[27-256]
-----------------------------------------------
E
F
K
P
W
I
Q
P
V
F
C
A
Q
T
G
-
V
-
L
---------
T
G
C
E
V
L
V
R
W
E
H
P
Q
-
T
-
G
I
I
P-
P
D
QF
I
------
P
L
A
E
S
S
G
L
------
I
V
I
M
T
R
--
Q
L
M
K
---
Q
T
A
D
I
L
M
P
V
K
H
LL
P
----
D
N
F
H
I
G
I
----------------------
N
V
S
A
G
C
F
-
L
A
---
A
--
G
F
E
K
E
C
L
N
L
V
N
K
L
G
N
D
K
I
K
L
V
L
E
L
T
E
R
N
PI
P
-------
V
-
T
P
E
A
R
A
I
-
F
D
S
L
H
Q
H
N
I
T
F
A
L
D
D
F
G
T
-
G
Y
--
A
T
---
Y
R
Y
L
Q
A
F
P
V
D
---------
F
I
K
I
D
--
K
S
--------
F
--
V
-------
Q
M
A
SVD
E
I
S
G
H
I
V
D
N
I
V
E
L
A
R
K
P
G
L
S
I
V
A
--
E
G
V
E
T
Q
E
-
Q
A
D
L
M
I
G
K
G
V
H
F
L
Q
G
Y
L
Y
S
P
P
------------
V
P
G
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Fugue
51.53
19%
11
- C1 -
4ZKD
3
SKI7_YEAST
A:
[7-499]
--------------------------------------------ID
I
H
S
F
I
A
T
H
P
L
N
L
T
-
C
L
-
F
-
L
G
D
T
NAG
K
S
T
L
L
G
H
L
L
Y
D
L
N
-
E
I
-
S
-
M
-
S
--
S
M
---------
R
------
E
------
L
Q
K
K
S
S
--
N
L
D
P
SSS
N
S
F
K
V
I
L
D
N
T
K
--
T
----
E
R
E
N
G
F
S
----------------------
M
F
K
K
V
I
Q
-
V
E
---
N
DL
L
P
----------
P
S
------
S
T
L
T
L
I
D
T
--
P
-------
G
-
S
I
K
Y
F
N
---
K
E
T
L
N
S
I
L
T
F
D
P
E
V
Y
V
L
V
I
D
--
C
N
Y
D
S
W
E
K
S
L
D
G
-
P
N
---------
N
Q
I
Y
E
--
I
L
--------
K
--
V
ISYLNKN
S
A
C
--------
K
K
H
L
I
I
L
L
N
K
A
D
L
I
S
W
D
K
--
H
R
L
E
M
I
Q
S
E
L
N
Y
V
L
K
E
N
F
Q
W
T
D
A
E
F
Q
F
I
P
C
S
GLLGSNLNKI
N
Y
V
P
E
W
Y
E
G
P
T
F
F
S
Q
L
Y
L
L
--
V
E
H
N
M
N
K
I
E
T
T
L
E
E
P
F
V
G
T
I
L
Q
S
S
V
L
Q
PIAE
I
N
Y
V
S
L
K
V
L
I
N
S
G
Y
I
Q
S
G
Q
T
I
E
I
H
T
Q
---------------
Y
E
D
F
H
Y
Y
G
I
-----
V
S
-
R
M
K
N
S
-
K
Q
I
-
L
--
E
T
----
N
T
K
N
N
I
S
V
G
L
N
P
D
I
L
E
V
L
V
---------
K
-
I
H
N
T
------
E
D
F
T
-
K
-
K
Q
F
H
I
R
K
G
D
I
I
I
H
S
RKTN
T
L
K
L
L
------
A
L
R
L
--------------------------------
I
-----------------------------------
K
L
S
I
Q
T
H
A
--
L
S
D
P
-
V
D
L
G
S
E
L
L
L
-
Y
H
N
--------
L
---------
T
H
N
A
V
K
--
L
V
K
I
L
G
--
T
N
D
------
I
S
-
I
N
P
--------
N
Q
S
----
L
I
V
E
V
E
I
I
E
P
D
F
A
L
N
V
I
D
S
K
YITN
N
I
V
L
T
S
IDHKVI
A
V
G
R
I
ACQ
25
HHSearch
51.44
19%
-85
* C4 *
3M1T
1
?
A:
[10-227]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
D
E
L
P
R
L
P
K
A
I
A
E
L
L
--
D
V
V
N
N
E
D
S
T
V
K
A
V
S
E
K
L
S
H
D
P
V
L
S
----------
A
R
V
L
R
L
A
N
S
A
------
E
V
G
T
I
D
D
A
--------
V
V
-
R
L
G
M
Q
T
L
R
T
L
V
I
-----
A
S
-
A
V
V
G
A
V
P
K
V
-
E
--
G
F
----
D
L
A
D
F
W
G
N
T
F
E
V
A
I
I
C
Q
E
L
---------
A
-
K
R
L
G
-------
T
L
P
-
E
-
E
A
F
T
C
G
I
L
H
S
I
G
---------
E
L
------
L
I
V
N
--------------------------------
G
D
P
A
V
A
A
T
I
S
A
A
V
A
D
GAD
R
N
L
M
E
K
E
L
LGYD
N
A
E
I
G
-
A
L
L
A
Q
S
W
K
--
F
T
P
H
-
L
--
V
K
G
I
Q
F
-
Q
N
H
PKSAEPYS
K
---------
L
A
G
M
L
A
--
M
A
K
Q
I
A
--
A
D
------------------------------------------------------------------------
39
HHSearch
51.35
22%
-31
* C3 *
3PJX
6
?
A:
[207-429]
-----------------------------------------------
R
F
E
L
F
F
Q
P
V
V
A
A
Q
D
T
-
Q
L
V
---------
L
H
Y
K
V
L
S
R
L
L
D
E
Q
-
G
Q
T
-
I
P
-
A
G
RF
L
P
W
L
E
R
F
G
------
W
------
T
A
R
L
D
R
--
L
M
L
E
---
R
V
L
E
Q
M
A
G
----------
H
E
E
S
L
A
L
----------------------
N
L
S
S
A
T
L
-
A
D
---
P
--
Q
A
L
N
K
V
F
E
I
L
R
A
H
S
N
L
G
A
R
L
T
L
E
I
G
E
E
Q
L-
P
-------
E
-
Q
A
V
L
E
Q
L
-
T
R
R
L
R
E
L
G
F
S
L
S
L
Q
R
F
G
G
-
R
F
--
S
M
---
I
G
N
L
A
R
L
G
L
A
---------
Y
L
K
I
D
--
G
S
--------
Y
--
I
-------
R
A
I
DQE
S
D
K
R
L
F
I
E
A
I
Q
R
A
A
H
S
I
D
L
P
L
I
A
--
E
R
V
E
T
E
G
-
E
L
S
V
I
R
E
M
G
L
Y
G
V
Q
G
Q
L
F
G
E
P
------------
K
P
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
51.27
23%
-25
- C3 -
3GFZ
3
?
A:
[176-398]
-----------------------------------------------
P
C
Q
F
A
L
Q
A
I
V
E
P
A
K
K
-
R
-
V
---------
S
S
F
E
A
L
I
R
S
P
T
G
G
---
S
-
P
--
V
E
M
--------
F
A
A
----
I
AAED
R
Y
R
F
D
L
E
S
--
K
A
Y
A
---
F
A
L
A
G
---
Q
L
P
--
L
----
G
K
H
Q
L
A
I
----------------------
N
L
L
P
G
S
L
Y
H
H
---
P
--
D
A
V
G
W
L
M
D
S
L
L
A
A
G
L
R
P
D
Q
V
L
I
E
V
T
E
T
E
V
I
T
-------
C
-
F
D
Q
F
R
K
V
-
L
K
A
L
R
V
A
G
M
K
L
A
I
D
D
F
G
A
-
G
Y
--
S
G
---
L
S
L
L
T
R
F
Q
P
D
---------
K
I
K
V
D
--
A
E
--------
L
--
V
-------
R
D
I
HIS
G
T
K
Q
A
I
V
A
S
V
V
R
C
C
E
D
L
G
I
T
V
V
A
--
E
G
V
E
T
L
E
-
E
W
C
W
L
Q
S
V
G
I
R
L
F
Q
G
F
L
F
S
R
P
------------
C
L
N
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
49.97
19%
-12
- C3 -
4HJF
3
?
A:
[88-319]
-----------------------------------------------
E
I
T
P
Y
F
Q
P
I
V
R
L
S
T
G
-
A
-
L
---------
S
G
F
E
A
L
A
R
W
I
H
P
R
R
G
-
M
-
L
P-
P
D
EF
L
P
L
I
E
E
M
G
------
L
------
M
S
E
L
G
A
--
H
M
M
H
---
A
A
A
Q
Q
L
S
T
W
R
A
--
A
H
PAM
G
N
L
T
V
S
V
----------------------
N
L
S
T
G
E
I
-
D
R
---
P
--
G
L
V
A
D
V
A
E
T
L
R
V
N
R
L
P
R
G
A
L
K
L
E
V
T
E
S
D
I
M
R
-------
D
-
P
E
R
A
A
V
I
-
L
K
T
L
R
D
A
G
A
G
L
A
L
D
D
F
G
T
-
G
F
--
S
S
---
L
S
Y
L
T
R
L
P
F
D
---------
T
L
K
I
D
--
R
Y
--------
F
--
V
-------
R
T
M
GNN
A
G
S
A
K
I
V
R
S
V
V
K
L
G
Q
D
L
D
L
E
V
V
A
--
E
G
V
E
N
A
E
-
M
A
H
A
L
Q
S
L
G
C
D
Y
G
Q
G
F
G
Y
A
P
A
------------
L
S
P
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
49.56
21%
-47
- C3 -
4Y9M
1
?
A:
[19-247]
-----------------------------------------------
E
F
I
P
Y
Y
Q
P
L
S
P
G
Q
G
G
-
R
-
W
---------
I
G
V
E
V
L
M
R
W
R
H
P
R
-
E
G
L
-
I
R-
P
D
LF
I
------
P
F
A
E
R
S
G
L
------
I
V
P
M
T
R
--
A
L
M
R
---
Q
V
A
E
D
L
G
G
H
A
G
KL
E
----
P
G
F
H
I
G
F
----------------------
N
I
S
A
T
H
C
-
H
E
---
L
--
A
L
V
D
D
C
R
E
L
L
A
A
F
P
P
G
H
I
T
L
V
L
E
L
T
E
R
E
L
I
E
-------
S
-
S
E
V
T
D
R
L
-
F
D
E
L
H
A
L
G
V
K
I
A
I
D
D
F
G
T
-
G
H
--
S
S
---
L
A
Y
L
R
K
F
Q
V
D
---------
C
L
K
I
D
--
Q
S
--------
F
--
V
-------
A
R
I
GID
T
L
S
G
H
I
L
D
S
I
V
E
L
S
A
K
L
D
L
D
I
V
A
--
E
G
V
E
T
P
E
-
Q
R
D
Y
L
A
A
R
G
V
D
Y
L
Q
G
Y
L
I
G
R
P
------------
M
P
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
49.31
21%
-7
- C3 -
4Q6J
7
?
A:
[19-242]
-----------------------------------------------
S
Y
L
L
Y
Y
Q
P
K
V
D
A
K
T
N
-
K
-
I
---------
I
G
F
E
G
L
V
R
L
K
T
A
T
-
T
-
I
-
L
A
-
P
I
DF
F
------
D
D
I
V
L
L
N
A
------
T
R
E
M
Q
D
--
F
V
A
E
---
T
A
I
K
Q
I
N
Q
L
----
G
----
G
R
F
S
I
S
I
----------------------
N
I
P
A
H
Y
V
-
A
S
---
S
--
T
Y
M
T
F
L
H
D
Y
V
K
E
H
L
K
Y
P
E
C
L
E
I
E
I
I
E
R
---
T
-------
E
-
L
A
I
A
D
K
N
-
L
R
K
I
K
D
L
G
V
K
V
S
M
D
D
F
G
K
-
G
Y
--
S
S
---
L
A
Y
L
R
S
L
P
I
D
---------
I
V
K
T
D
--
M
S
--------
F
--
I
-------
A
L
L
KTD
R
K
Q
Q
I
I
I
R
A
I
V
N
L
C
H
D
L
G
G
K
V
V
T
--
E
G
V
E
D
M
E
-
Q
V
E
K
L
R
E
M
K
V
D
Y
F
Q
G
Y
Y
F
S
R
P
------------
L
P
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
49.25
17%
-92
- C- -
3I7A
-
?
A:
[19-237]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
I
L
P
T
L
P
E
V
A
M
R
V
Q
--
E
V
V
G
R
P
D
S
S
L
K
Q
V
A
E
I
I
G
Q
D
A
A
I
S
----------
A
R
I
I
K
V
A
N
S
A
L
Y
S
R
G
V
P
A
E
N
I
N
S
A
--------
V
T
-
R
I
G
L
T
Q
I
K
S
I
A
T
-----
S
V
-
A
M
E
Q
L
F
I
S
T
N
E
MV
W
E
----
V
M
D
E
V
W
R
T
S
I
D
V
T
A
A
A
C
S
L
---------
L
-
Q
I
Y
N
K
K
H
PGS
G
L
N
Y
-
D
-
T
L
T
L
A
G
L
V
H
N
I
G
---------
A
L
------
P
V
L
T
--------------------------------
E
A
E
A
H
PEMFTT
I
E
H
L
R
S
L
V
R
K
M
Q
G
P
I
G
---------
R
A
V
L
K
S
W
D
--
F
A
P
E
-
V
--
M
E
V
V
E
R
-
W
A
D
LPYLGDHV
S
---------
Y
L
D
F
I
R
--
A
A
A
F
Y
T
--
G
E
------------------------------------------------------------------------
23
HHSearch
47.63
20%
-21
- C3 -
2BAS
-
YKUI_BACSU
A:
[37-264]
-----------------------------------------------
D
V
L
P
Y
Y
Q
A
I
F
S
A
E
E
Q
-
K
-
V
---------
V
G
Y
E
V
L
G
R
I
L
A
D
S
-
E
-
I
-
Q
S
L
G
P
F
F
L
------
D
------
A
GIP
E
E
Y
K
L
E
V
D
N
--
R
I
I
R
---
Q
A
L
D
R
F
L
E
A
----
D
----
S
D
L
L
I
F
M
----------------------
N
Q
D
A
N
L
L
-
M
L
DHG
E
--
S
F
L
E
L
L
K
E
Y
E
A
-
K
G
I
E
L
H
R
F
V
L
E
I
T
E
H
N
FE
G
-------
D
-
I
E
Q
L
Y
H
M
-
L
A
Y
Y
R
T
Y
G
I
K
I
A
V
D
N
I
G
K
-
E
S
--
S
N
---
L
D
R
I
A
L
L
S
P
D
---------
L
L
K
I
D
--
L
Q
--------
A
--
L
-------
K
--SP
S
Y
E
H
--
V
L
Y
S
I
S
L
L
A
R
K
I
G
A
A
L
L
Y
--
E
D
I
E
A
N
F
-
Q
L
Q
Y
A
W
R
N
G
G
R
Y
F
Q
G
Y
Y
L
V
S
P
------------
S
E
T
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
46.14
16%
-38
- C3 -
4J40
-
?
A:
[455-683]
-----------------------------------------------
S
F
R
L
L
F
Q
P
V
I
S
L
R
G
D
-
S
-
H
---------
E
N
Y
E
V
L
L
R
L
L
N
P
Q
-
G
-
Q
E
V
P
-
P
A
E
F
L
------
H
A
A
K
E
A
G
L
------
A
E
K
I
D
R
--
W
V
I
L
---
N
S
I
K
L
L
A
E
H
R
A
K
-
G
----
H
Q
T
K
L
F
V
----------------------
H
L
S
S
A
S
L
-
Q
D
---
P
--
G
L
L
P
W
L
G
V
A
L
K
A
A
R
L
P
P
E
S
L
V
F
Q
I
S
E
A
D
A
T
S
-------
Y
-
L
K
Q
A
K
Q
L
-
T
Q
G
L
A
T
L
H
C
Q
A
A
I
S
Q
F
G
C
-
S
L
--
N
P
---
F
N
A
L
K
H
L
T
V
Q
---------
F
I
K
I
D
--
G
S
--------
F
--
V
-------
Q
D
L
NQ
V
E
N
Q
E
-
I
L
K
G
L
I
A
E
L
H
E
Q
Q
K
L
S
I
V
--
P
F
V
E
S
A
S
-
V
L
A
T
L
W
Q
A
G
A
T
Y
I
Q
G
Y
Y
L
Q
G
P
------------
S
Q
A
M
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
45.65
17%
32
- C3 -
2BAS
1
YKUI_BACSU
A:
[26-431]
------------------------------------LD
P
L
D
I
L
T
N
I
D
D
V
L
P
Y
Y
Q
A
I
F
S
A
-
E
E
Q
K
-
V
---------
V
G
Y
E
V
L
G
R
I
L
-
A
D
-
S
-
E
-
I
--
Q
S
---------
L
------
G
------
P
F
F
L
D
A
--
G
I
P
E
---
E
Y
K
L
E
V
D
N
R
I
I
--
R
----
Q
A
L
D
R
F
L
E
A
DSD
L
L
I
F
M
N
Q
D
A
N
L
L
M
LDHG
E
S
F
L
E
L
L
-
K
E
---
Y
--
E
A
----------
K
G
I
E
L
H
R
F
V
L
E
I
T
E
H
N
--
F
-------
E
G
D
I
E
Q
L
Y
H
M
L
A
Y
Y
R
T
Y
G
I
K
I
A
V
D
N
I
-
G
K
E
S
--
S
N
L
D
R
I
A
L
L
--
S
-
P
D
---------
L
L
K
I
D
LQ
A
L
--------
K
SP
S
-------
Y
E
H
--------
V
L
Y
S
I
S
L
L
A
R
K
I
G
A
A
L
L
Y
--
E
D
I
E
A
N
F
-
Q
L
Q
Y
A
W
R
N
G
G
R
Y
F
Q
G
Y
Y
L
V
S
P
------------
S
E
T
F
L
E
R
D
V
L
K
Q
R
L
K
T
E
F
H
--
Q
F
I
T
H
E
K
K
K
L
E
T
V
Y
E
H
S
E
Q
F
Y
K
R
V
----------
H
Q
A
V
T
S
L
R
K
N
N
L
------
S
S
D
D
D
F
--------
I
K
-
K
L
A
E
E
L
T
D
C
S
F
R
-----
I
Y
M
C
D
E
E
G
-
D
Q
L
-
T
--
G
N
----
V
F
K
Q
D
G
E
W
I
Y
Q
P
E
Y
A
E
K
N
W
---------
S
W
R
P
Y
F
------
L
E
N
I
M
R
M
R
N
L
R
K
G
F
F
S
D
L
Y
---------
S
D
------
L
E
T
---------------------------------------------------------------------------------
G
E
M
I
--
R
T
F
S
Y
P
M
D
D
Q
M
-------
Y
---------
L
F
I
D
L
P
--
Y
S
Y
L
Y
E
--
Q
D
G
------
L
I
---------------------------------------------------------------
21
HHSearch
45.64
17%
-30
- C4 -
3MEM
4
?
A:
[181-448]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
E
L
P
P
L
P
E
T
A
Q
R
I
I
--
H
L
R
V
N
P
N
A
V
M
G
D
L
V
D
V
V
E
S
D
P
S
L
A
----------
A
Q
V
V
S
W
A
S
S
S
F
Y
A
A
A
G
R
V
H
S
V
H
D
A
--------
V
S
R
V
L
G
F
D
L
V
M
N
L
A
M
-----
G
L
-
A
L
G
R
A
L
K
H
P
-
Q
DH
P
D
----
G
Y
V
D
Y
W
Q
Q
A
I
W
Q
A
Q
S
A
G
I
L
---------
A
-
S
M
M
P
RGQ---
R
P
L
F
-
G
-
L
A
Y
L
A
G
L
L
H
N
F
G
---------
H
L
------
V
L
A
Q
V
F
P
P
H
F
K
L
V
C
R
S
L
E
V
S
PHID
S
S
V
I
E
H
Y
L
LGIT
R
E
Q
I
A
-------------------------------
A
Q
L
M
E
N
W
G
--
M
P
D
E
-
V
--
T
L
A
I
R
Y
-
Q
K
N
--------
P
AYDGPH
N
V
-
Y
A
R
L
L
W
--
L
G
R
Q
L
L
--
T
E
R
GVALGA
G
E
S
A
T
Q
A
V
Y
D
E
L
G
L
D
R
E
----
L
V
Q
E
Q
F
D
E
L
V
R
R
K
D
S
I
M
A
--------------------------
42
Fugue
44.29
18%
-23
* C5 *
5DSE
-
TTC7B_HUMAN
A:
[140-843]
V
I
A
E
A
Y
A
T
K
G
L
C
L
ED
V
I
T
C
Y
E
K
A
G
D
I
A
L
L
Y
L
Q
E
I
E
R
VLG
F
F
L
E
T
G
L
Q
R
A
H
V
L
Y
F
K
N
G
N
L
-
T
R
-
G
-
V
---------
G
R
F
R
E
L
L
R
A
V
-
E
T
-
R
-
T
-
T
--
Q
N
---------
L
------
R
------
M
T
I
A
R
Q
L
A
E
I
L
L
---
R
G
M
C
E
Q
S
Y
W
N
P
--
L
----
E
D
P
F
C
P
Q
E---------------------
N
T
E
E
A
L
L
-
L
L
---
L
--
I
S
----------
E
S
M
A
N
R
S
V
V
Y
D
L
L
T
I
A
--
L
G
R
R
GQ
Y
E
M
-
L
S
E
C
L
E
R
-
A
M
K
F
A
F
E
E
F
H
L
W
Y
Q
F
A
L
S
L
M
A
A
G
K
S
A
R
A
V
K
V
L
K
E
C
-
I
R
L
KPDDA
T
I
P
L
L
A
A
K
--
L
C
M
G
SLHW
L
E
E
--
A
-------
E
K
F
--------
A
K
T
V
V
T
S
E
F
K
A
K
G
Y
L
A
L
G
L
T
Y
S
L
Q
A
T
D
-
A
S
L
R
G
M
Q
E
V
L
Q
R
K
A
L
L
A
F
Q
R
A
------------
H
S
L
S
P
T
D
H
Q
A
A
F
Y
L
A
L
Q
L
A
I
S
R
Q
I
P
E
A
L
G
Y
V
R
Q
A
L
Q
L
Q
G
D
D
-
A
N
S
----------
L
H
L
L
A
L
L
L
S
A
Q
K
H
Y
H
D
A
L
N
I
I
D
M
A
L
S
E
Y
PEN
F
I
L
-
L
F
S
K
V
K
L
Q
S
L
C
R
G
P
D
E
A
L
L
-
T
C
K
H
M
-
L
Q
I
-
W
--
K
S
C
YLH
P
W
M
T
L
A
Q
I
W
L
H
A
A
E
V
Y
I
G
I
GK
P
A
E
A
T
A
C
T
-
Q
E
A
A
------
N
L
F
P
-
M
-
S
H
N
V
L
Y
M
R
G
Q
I
A
---------
E
L
R
GS
M
D
E
A
R
R
W
--------------------------------
Y
-----------------------------------
E
E
A
L
A
I
S
P
TH
V
K
S
M
-
Q
--
R
L
A
L
I
L
-
H
Q
L
--------
G
---------
R
Y
S
L
A
E
K
I
L
R
D
A
V
Q
V
N
S
T
A
------
H
E
-
V
W
N
G
L
G
E
--
V
L
Q
A
Q
GN
D
A
A
A
T
E
C
F
L
T
A
L
E
L
E
A
S
S
P
A
V
P
FTIIPRVL----------------
27
HHSearch
44.26
16%
-17
- C3 -
3HV8
1
?
A:
[32-260]
-----------------------------------------------
S
F
R
L
L
F
Q
P
V
I
S
L
R
G
D
-
S
-
H
---------
E
N
Y
E
V
L
L
R
L
L
N
P
Q
-
G
Q
E
-
V
P
-
P
A
EF
L
H
A
A
K
E
A
G
------
L
------
A
E
K
I
D
R
--
W
V
I
L
---
N
S
I
K
L
L
A
E
H
----------
Q
T
K
L
F
V
----------------------
H
L
S
S
A
S
L
-
Q
D
---
P
--
G
L
L
P
W
L
G
V
A
L
K
A
A
R
L
P
P
E
S
L
V
F
Q
I
S
E
A
D
A
T
S
-------
Y
-
L
K
Q
A
K
Q
L
-
T
Q
G
L
A
T
L
H
C
Q
A
A
I
S
Q
F
G
C
-
S
L
--
N
P
---
F
N
A
L
K
H
L
T
V
Q
---------
F
I
K
I
D
--
G
S
--------
F
--
V
-------
Q
D
L
NQ
V
E
N
Q
E
-
I
L
K
G
L
I
A
E
L
H
E
Q
Q
K
L
S
I
V
--
P
F
V
E
S
A
S
-
V
L
A
T
L
W
Q
A
G
A
T
Y
I
Q
G
Y
Y
L
Q
G
P
------------
S
Q
A
M
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------