@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu31875: (2016-07-23 )
MSLLWVFYQNNVQKLNLSNLPSSHPVTIGPDVKDSVTISTIPFNSGVISLKRKESGGQYEVFLGNDCLGTIETDISFTLQTDQQDIRLILTGSEPEKSVYFTGNRDEIVCSSEKTNADIYLNPQDFAFAEQSTFSLLRAGGSWSVRPESGTIFLNGEKINANTPLKPGDEIFWNFTQMRVTEQDLLEIVHYAQFETALTETVKPSTEMQKKYPQYRRTPRMVYDLPDDRVSFSFPSQESDQTNRGLWLVILPPLVMLIVMGVVAIIQPRGIFILVSLAMFMMTLITSTVQYFRDKNQRKKREEKRERVYKLYLDNKRKELQALAEKQKQVLEFHFPSFEQMKYLTSEISDRIWEKSLESKDYLQLRLGTGTVPSSYEINMSGGDLANRDIDDLMEKSQHMQRVYKDIRNAPVTVDLAEGPMGLVGKSQIVKNEIHQLIGQLSFFNSYHDLRFVFIFHEEEYKDWEWMKWLPQFQMPHIYAKGFIYNEQTRDQLLSSLYELIRERDLEDDKEKLQFKPHFVFVITNQQLISEHVILEYLEGQHEHLGISTIVAAETKESLSENITTLVRYINEHEGDILIQKKKAVRIPFRLDHHQREDNERFSRTLRTLNHQVGITNSIPETVSFLELFHAKEVKEIGIQQRWLTSESSKSLSVPIGYKGKDDIVYLNLHEKAHGPHGLLAGTTGSGKSEFLQTYILSLAVHFHPHEAAFLLIDYKGGGMAQPFRNIPHLLGTITNIEGSKNFSMRALASIKSELKKRQRLFDQYQVNHINDYTKLYKQGKAEVAMPHLFLISDEFAELKSEEPDFIRELVSAARIGRSLGVHLILATQKPGGIIDDQIWSNSRFKVALKVQDATDSKEILKNSDAANITVTGRGYLQVGNNEVYELFQSAWSGAPYLEEVYGTEDEIAIVTDTGLIPLSEVDTEDNAKKDVQTEIEAVVDEIERIQDEMGIEKLPSPWLPPLAERIPRTLFPSNEKDHFHFAYVDEPDLQRQAPIAYKMMEDGNIGIFGSSGYGKSIAAATFLMSFADVYTPEELHVYIFDFGNGTLLPLAKLPHTADYFLMDQSRKIEKFMIRIKEEIDRRKRLFREKEISHIKMYNALSEEELPFIFITIDNFDIVKDEMHELESEFVQLSRDGQSLGIYFMLTATRVNAVRQSLLNNLKTKIVHYLMDQSEGYSIYGRPKFNLEPIPGRVIIQKEELYFAQMFLPVDADDDIGMFNELKSDVQKLQGRFASMEQPAPIPMLPESLSTRELSIRFKLERKPLSVPIGLHEETVSPVYFDLGKHKHCLILGQTQRGKTNVLKVMLEHLIDDETEMIGLFDSIDRGLSHYAKESDVSYLETKEDIEQWIETAEDIFKTREAMYVEAVRQGDAQNLRFSQVVLMIDGITRFQQTIDTRIQDRLANFMKSYAHLGFSFIPGGNHSEFSKGYDSLTTEMKQIRHAILLMKKSEQNVIPLPYQRQEPEIQPGFGYVVENGKEQKVQIPLCSAERESAR
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.....-..150.......160.......170.......180.....--..190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.....--.-------.420....-...430.......440.......450.......460.......470.......480.......490.......500.......510---------------.........520.......530.----.......540.......550.......--560-.........--570.--.-----------------.....580.......590....-------...600.......610.-.-----.--....620........630----.....--..640.......650.......-----660----........670--...---.---....680.......690.......700----........710.......720.......730-.-......740.......750.......-760...-.-..---.770...---------------....780-------------------.-..---------------------...-------...790.......800.-......810-.-......820.......830-..-.....840.......850.......860.......--870.-...---....880-----------.........890.--...-...900.......910.......920.......930.......940.......950......---.960.......970-----......-----------------...980.......990.......1000-.......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100----.--------------------------.------......1110......1120-......1130......1140......1150-..---.--....-1160.--.....1170......1180..--....1190......---1200......1210...--...1220.......1230......1240......1250......1260....----..1270......1280......-----1290......1300......1310---......1320..--....1330-......1340......1350......1360......1370.-..-...1380......1390......1400......1410......1420......-1430......1440.......1450.......1460......1470....-..1480......1490..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
S
L
L
W
V
F
YQN
N
V
Q
KLNLSNLPSSHPVTIGPDVKD
S
V
T
I
S
T
I
PFNS
G
V
I
S
L
K
RKESGG
Q
Y
E
V
F
LGNDCL
G
T
IET
D
I
S
F
T
L
QTDQQ
D
I
R
L
I
L
TGSEPE
K
S
V
Y
F
TGNR
D
E
I
V
CSSEKTN
A
D
I
Y
LNPQDFA
F
A
E
Q
S
T
F
S
L
L
RAGGS
W
S
V
RP-ES
G
T
I
F
LN
G
E
KINANTPLKPGD
E
I
F
W
N
F
T
QMRV
T
E
Q
D
L
L
E
--
I
V
H
Y
A
Q
F
E
T
A
L
T
ETVKP
S
T
E
M
Q
K
K
Y
P
Q
Y
RRTP
R
M
V
Y
DLPDD
R
V
S
F
SFPSQESDQTNR
G
L
W
L
V
I
L
P
P
L
V
M
L
I
V
M
G
V
V
A
I
IQPR
G
I
F
I
L
V
S
L
A
M
F
M
M
T
L
I
T
S
T
V
Q
Y
F
R
D
K
N
Q
R
K
K
R
E
E
K
R
E
R
V
Y
K
L
Y
LDN
K
R
K
E
L
Q
A
L
A
E
K
Q
K
Q
V
L
E
F
HFP
S
F
E
Q
M
K
Y
L
T
S
E
I
S
D
R
I
W
E
K
SLESK
D
Y
L
Q
L
R
LGTGTVP
S
S
Y
E
I
NMSGGDLANR
D
I
D
D
L
M
E
K
S
Q
H
M
Q
R
V
Y
K
D
IRNA
P
V
T
V
D
LA--E-------GPMGLV
G
K
-
S
Q
I
V
K
N
E
I
H
Q
L
I
G
Q
L
S
F
F
NSYH
D
L
R
F
V
F
I
F
HEEEYK
D
W
E
W
M
K
W
L
P
QFQM
P
H
I
Y
AK
G
F
I
YN
E
Q
T
R
D
Q
L
L
S
S
L
Y
E
L
I
R
ERDLED
D
K
-----------------
E
KLQFKP
H
F
V
F
V
IT
N
Q
Q
L
I
S
E
-
H
----
V
I
L
E
Y
L
EGQ
H
E
HLG
I
S
T
I
V
A
A
E
T
K
E
S
L
--
S
---
E
N
I
T
T
L
V
R
Y
--
I
N
EH--E-----------------G
D
I
L
I
Q
KK
K
A
V
RI
P
F
RLDHHQR-------E
D
N
E
R
F
S
R
T
L
R
T
L
N
HQV-G-----I--TNSI
P
-
E
T
V
S
F
L
E
L
F
H
A
K
----
E
V
K
E
I--G
I
Q
Q
RWLTSESSKSLSVPIGYK-----GK-----D
D
I
V
Y
L
N
LHE---KAH---G---PH
G
L
LAGTTGS
G
K
S
E
F
L
Q
T
Y
I
L
S
L
A
V
-----
H
FHPH
E
A
A
F
L
L
I
DYKGGGMA
Q
P
F
R
NI
P
H
L
L
G
-
T
-
I
TNIEGSKNF
S
M
R
A
L
A
S
I
K
S
E
L
K
K
R
Q
-
R
L
F
D
Q
Y
-
Q
-VN---H
I
N
D
Y
T
K
---------------
L
Y
KQG---------------------K-AE---------------------VAM-------
P
H
L
F
L
I
S
D
E
F
A
E
L
KSEE-
P
D
F
I
R
E
L
V
S
-
A
-
A
R
I
G
R
SL
G
V
H
L
I
L
A
TQKPG-GI-IDDQIWSNS
R
F
K
V
A
L
K
VQDAT
D
S
K
E
I
LKNSDA
A
N
I
--
T
-
V
T-G
R
G
---
Y
L
Q
VG-------------N
N
E
V
Y
E
L
F
Q
S
AWS--GA
P
-
Y
L
E
E
VYGTED
E
I
A
I
V
TDTG
L
I
PLSEVDTEDNA
K
K
D
V
Q
T
E
I
E
A
V
V
D
E
I
E
R
I
Q
D
E
MG
I
E
KLPSP---WLP
P
L
A
E
RI
P
R
T
-------LFPSNE-----------------KD
H
F
H
F
A
YVDEPDLQRQA
P
I
A
Y
K
M
-ME-DG
N
I
G
I
F
GSSGYG
K
S
I
A
A
A
T
F
L
M
S
F
A
D
VYTPE
E
L
H
V
Y
I
F
DFGN
G
T
L
L
P
LAKLPHTAD
Y
F
LMDQS
R
K
I
E
K
F
M
I
R
I
K
E
E
I
D
R
R
K
R
L
F
R
E
K
E
I
S
H
I
K
M
Y
NAL------S--------------------------E------EEL
P
F
I
F
I
T
IDN
F
D
I
V
K
D
E
M
-
H
E
L
E
S
E
F
V
Q
LSRDGQ
S
L
G
I
Y
F
M
L
T
A
T
R
V
N
--
A
V
---
R
--
Q
S
L
L
-
N
N
L
K
T
--
K
I
V
H
Y
L
MDQSE
G
Y
S
I
YGRPKF--NLEPIP
G
R
V
I
I
Q
KE---
E
L
Y
F
A
Q
M
F
L
PVDADDDI--
G
M
F
N
E
-
L
K
S
D
V
Q
K
L
Q
G
R
FASMEQPAPIPMLPESLST
R
E
L
S
I
R
F
K
LERKPLSV----PIGLHEETVS
P
V
Y
FDLGKH
K
H
C
-----
L
I
L
GQTQRG
K
T
N
V
L
K
V
M
L
E
H
LIDD---E
T
E
M
I
G
L
F
D
S
I
D
--
R
G
L
S
H
Y
A
K-ESD
V
S
Y
L
E
T
K
E
D
I
E
Q
W
I
E
T
A
E
D
I
F
K
T
R
E
A
M
Y
V
E
A
V
RQGDAQ-N
L
-
R
F
S
Q
V
V
L
M
ID
G
I
T
R
F
Q
Q
T
I
D
T
R
I
Q
D
R
L
A
N
F
M
K
S
Y
A
HLG
F
S
FIPGGN
H
S
E
F
S
K
G
-
Y
D
S
L
T
T
E
M
K
Q
I
-
R
H
A
I
L
L
M
KKS-EQNVIPLPYQRQEPEIQPG
F
G
Y
V
VENG-KE
Q
K
V
Q
IPLCSAERESAR
2
PsiBlast_PDB
78.27
50%
-121
- C2 -
4LYA
3
?
A:
[31-556]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
P
L
P
P
R
L
A
R
P
-------
A
S
V
T
A
E
-----------------
A
N
A
F
P
I
G
L
K
D
E
P
E
L
Q
S
Q
S
D
Y
F
Y
Q
W
-
L
E
-
D
G
N
I
G
I
F
G
S
A
G
Y
G
K
S
T
T
M
M
T
L
L
L
S
F
A
G
A
Y
N
P
A
Q
L
H
Y
Y
I
F
D
F
G
N
S
A
L
L
P
L
R
Q
L
P
H
T
A
D
Y
F
R
L
D
D
E
K
K
I
E
K
F
I
K
F
M
K
E
E
M
E
Q
R
K
Q
R
F
M
E
K
E
V
S
T
I
K
L
Y
N
A
L
------
S
--------------------------
E
------
E
K
L
P
I
I
I
V
A
L
D
N
F
D
V
V
K
E
E
M
-
P
D
F
E
T
Q
L
I
Q
Y
A
R
D
G
Q
S
L
G
I
F
F
I
M
T
A
T
R
V
S
--
G
I
---
R
--
P
P
L
M
-
N
N
L
K
T
--
K
I
V
H
Y
F
I
D
S
S
E
K
F
S
L
I
G
R
T
P
Y
--
D
V
D
P
I
P
G
R
A
L
I
K
K
D
---
N
A
A
L
T
Q
I
Y
L
P
A
D
G
E
D
D
I
--
E
V
L
E
N
-
V
K
R
E
M
E
R
L
K
E
V
Y
Q
H
I
P
K
P
K
P
I
P
M
L
P
P
R
L
S
M
S
V
F
T
N
T
Y
V
Q
H
R
A
S
G
F
I
----
P
V
G
L
D
E
Q
T
V
R
P
V
A
I
N
M
R
T
D
P
H
C
-----
L
I
V
G
Q
S
R
K
G
K
T
N
V
V
K
V
I
L
E
S
L
L
V
Q
---
E
P
E
S
I
G
L
L
D
G
I
D
--
R
G
L
A
G
Y
A
N
-
R
D
D
I
T
Y
I
E
A
K
E
R
L
A
Q
W
L
N
E
A
D
A
V
L
Q
Q
R
E
R
E
Y
I
Q
A
V
N
----------
W
P
P
V
V
F
V
V
D
S
L
L
R
L
Q
Q
E
T
D
S
I
M
Q
G
R
I
A
N
M
M
K
Q
Y
S
H
L
G
F
H
V
F
V
A
G
N
A
N
E
F
V
K
G
-
F
D
A
L
T
A
E
L
K
Q
I
-
R
Q
A
I
L
V
T
K
K
S
-
E
Q
S
L
F
A
L
P
F
T
R
N
E
Q
E
I
E
P
G
F
G
Y
F
V
V
G
G
-
K
D
Q
K
I
Q
I
P
----------
22
HHSearch
78.08
50%
-112
- C2 -
4LYA
3
?
A:
[31-558]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
P
L
P
P
R
L
A
R
P
-------
A
S
V
T
A
E
-----------------
A
N
A
F
P
I
G
L
K
D
E
P
E
L
Q
S
Q
S
D
Y
F
Y
Q
W
-
L
E
-
D
G
N
I
G
I
F
G
S
A
G
Y
G
K
S
T
T
M
M
T
L
L
L
S
F
A
G
A
Y
N
P
A
Q
L
H
Y
Y
I
F
D
F
G
N
S
A
L
L
P
L
R
Q
L
P
H
T
A
D
Y
F
R
L
D
D
E
K
K
I
E
K
F
I
K
F
M
K
E
E
M
E
Q
R
K
Q
R
F
M
E
K
E
V
S
T
I
K
L
Y
N
A
L
------
S
--------------------------
E
------
E
K
L
P
I
I
I
V
A
L
D
N
F
D
V
V
K
E
E
M
-
P
D
F
E
T
Q
L
I
Q
Y
A
R
D
G
Q
S
L
G
I
F
F
I
M
T
A
T
R
V
S
--
G
I
---
R
--
P
P
L
M
-
N
N
L
K
T
--
K
I
V
H
Y
F
I
D
S
S
E
K
F
S
L
I
G
R
T
P
Y
--
D
V
D
P
I
P
G
R
A
L
I
K
K
D
---
N
A
A
L
T
Q
I
Y
L
P
A
D
G
E
D
D
I
--
E
V
L
E
N
-
V
K
R
E
M
E
R
L
K
E
V
Y
Q
H
I
P
K
P
K
P
I
P
M
L
P
P
R
L
S
M
S
V
F
T
N
T
Y
V
Q
H
R
A
S
G
F
I
----
P
V
G
L
D
E
Q
T
V
R
P
V
A
I
N
M
R
T
D
P
H
C
-----
L
I
V
G
Q
S
R
K
G
K
T
N
V
V
K
V
I
L
E
S
L
L
V
Q
---
E
P
E
S
I
G
L
L
D
G
I
D
--
R
G
L
A
G
Y
A
N
-
R
D
D
I
T
Y
I
E
A
K
E
R
L
A
Q
W
L
N
E
A
D
A
V
L
Q
Q
R
E
R
E
Y
I
Q
A
V
N
----------
W
P
P
V
V
F
V
V
D
S
L
L
R
L
Q
Q
E
T
D
S
I
M
Q
G
R
I
A
N
M
M
K
Q
Y
S
H
L
G
F
H
V
F
V
A
G
N
A
N
E
F
V
K
G
-
F
D
A
L
T
A
E
L
K
Q
I
-
R
Q
A
I
-
L
V
T
K
K
S
E
Q
S
L
F
A
L
P
F
T
R
N
E
Q
E
I
E
P
G
F
G
Y
F
V
V
G
G
-
K
D
Q
K
I
Q
I
P
K
V
--------
1
PsiBlast_PDB
76.78
50%
-129
- C2 -
5FV0
2
?
A:
[6-514]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
N
A
F
P
I
G
L
K
D
E
----
S
Q
S
D
Y
F
Y
Q
W
-
L
E
-
D
G
N
I
G
I
F
G
S
A
G
Y
G
K
S
T
T
M
M
T
L
L
L
S
F
A
G
A
Y
N
P
A
Q
L
H
Y
Y
I
F
D
F
G
N
S
A
L
L
P
L
R
Q
L
P
H
T
A
D
Y
F
R
L
D
D
E
K
K
I
E
K
F
I
K
F
M
K
E
E
M
E
Q
R
K
Q
R
F
M
E
K
E
V
S
T
I
K
L
Y
N
A
L
------
S
--------------------------
E
------
E
K
L
P
I
I
I
V
A
L
D
N
F
D
V
V
K
E
E
M
-
P
D
F
E
T
Q
L
I
Q
Y
A
R
D
G
Q
S
L
G
I
F
F
I
M
T
A
T
R
V
S
--
G
I
---
R
--
P
P
L
M
-
N
N
L
K
T
--
K
I
V
H
Y
F
I
D
S
S
E
K
F
S
L
I
G
R
T
P
Y
--
D
V
D
P
I
P
G
R
A
L
I
K
K
D
---
N
A
A
L
T
Q
I
Y
L
P
A
D
G
E
D
D
I
--
E
V
L
E
N
-
V
K
R
E
M
E
R
L
K
E
V
Y
Q
H
I
P
K
P
K
P
I
P
M
L
P
P
R
L
S
M
S
V
F
T
N
T
Y
V
Q
H
R
A
S
G
F
I
----
P
V
G
L
D
E
Q
T
V
R
P
V
A
I
N
M
R
T
D
P
H
C
-----
L
I
V
G
Q
S
R
K
G
K
T
N
V
V
K
V
I
L
E
S
L
L
V
Q
---
E
P
E
S
I
G
L
L
D
G
I
D
--
R
G
L
A
G
Y
A
N
-
R
D
D
I
T
Y
I
E
A
K
E
R
L
A
Q
W
L
N
E
A
D
A
V
L
Q
Q
R
E
R
E
Y
I
Q
A
V
N
E
N
R
A
T
-
T
L
-
A
W
P
P
V
V
F
V
V
D
S
L
L
R
L
Q
Q
E
T
D
S
I
M
Q
G
R
I
A
N
M
M
K
Q
Y
S
H
L
G
F
H
V
F
V
A
G
N
A
N
E
F
V
K
G
-
F
D
A
L
T
A
E
L
K
Q
I
-
R
Q
A
I
L
V
T
K
K
S
-
E
Q
S
L
F
A
L
P
F
T
R
N
E
Q
E
I
E
P
G
F
G
Y
F
V
V
G
G
-
K
D
Q
K
I
Q
I
P
----------
42
Fugue
71.57
25%
14
- C2 -
4NH0
5
?
A:
[246-1147]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-
A
N
M
T
L
T
S
L
L
H
I
D
----
N
P
Y
N
L
--
D
P
A
V
L
W
R
P
R
P
Q
R
N
R
L
R
V
P
I
G
L
D
-----
A
D
-----
G
R
P
L
E
L
D
I
K
E
---
S
A
Q
GGM
G
---
P
H
G
L
C
I
G
A
T
G
S
G
K
S
E
L
L
R
T
L
V
L
A
L
A
M
-----
T
H
S
P
E
V
L
N
F
V
L
V
D
F
K
G
G
A
T
F
L
G
M
E
G
L
R
H
V
S
A
-
I
-
I
T
N
L
E
E
E
L
P
L
V
D
R
M
Y
D
A
L
H
G
E
M
V
R
R
Q
-
E
H
L
R
H
S
G
N
-
Y
A
---
S
L
R
D
Y
E
K
---------------
A
R
M
E
G
---------------------
A
-
P
L
---------------------
P
P
M
-------
P
T
L
F
I
V
L
D
E
F
S
E
L
L
S
A
K
-
P
D
F
A
E
L
F
V
M
-
I
-
G
R
L
G
R
S
L
G
V
H
L
L
L
A
S
Q
R
L
E
-
E
G
-
K
L
R
G
L
D
T
H
L
S
Y
R
I
G
L
R
T
F
S
A
M
E
S
R
V
V
L
G
V
P
D
A
Y
E
L
--
P
-
P
S
P
G
N
G
---
Y
L
K
F
A
-------------
T
E
P
L
V
R
-
F
K
A
A
Y
V
--
S
G
P
-
V
D
E
E
------------
S
E
S
L
F
D
V
V
V
R
Q
L
A
G
H
G
P
E
P
H
Q
I
W
L
P
P
-------
L
D
V
P
P
T
L
D
E
L
L
P
P
---
L
S
P
S
A
A
H
G
Y
T
A
D
-------
G
W
E
W
R
G
-----------------
R
L
H
A
V
V
G
L
V
D
R
P
F
D
Q
R
R
D
P
Y
W
L
D
L
-
S
G
G
A
G
H
V
G
V
A
G
G
P
Q
T
G
K
S
T
M
L
R
T
L
I
T
S
L
A
L
L
H
T
P
Q
E
V
Q
F
Y
C
L
D
F
G
G
G
T
L
A
G
L
A
E
L
P
H
V
G
S
V
A
T
R
L
D
A
D
R
I
R
R
T
V
A
E
V
S
A
L
L
E
Q
R
E
Q
E
F
T
E
R
G
I
D
S
M
A
T
Y
R
R
L
------
R
--------------------------
A
T
GEYAG
D
G
F
G
D
V
F
L
V
V
D
N
W
L
T
L
R
Q
D
Y
-
E
A
L
E
D
S
I
T
Q
L
A
A
R
G
L
G
Y
G
I
H
V
V
L
S
S
N
K
W
S
--
E
F
---
R
--
T
S
I
R
-
D
L
L
G
T
--
K
L
E
L
R
L
G
D
P
Y
E
S
E
V
D
R
K
K
A
A
N
--
V
P
E
N
R
P
G
R
G
L
T
R
D
G
---
Y
H
F
L
T
A
L
P
R
I
D
G
D
T
S
A
E
--
T
L
T
E
G
-
I
A
T
T
V
K
T
I
R
E
A
W
H
G
P
T
A
P
-
P
V
R
M
L
P
N
V
L
P
A
A
Q
L
P
S
A
A
E
S
G
T
R
---
I
----
P
I
G
I
D
E
D
S
L
S
P
V
Y
L
D
F
N
T
D
P
H
F
-----
L
V
F
G
D
T
E
C
G
K
S
N
L
L
R
L
I
T
A
G
I
I
E
R
---
Y
T
P
Q
Q
A
R
L
I
F
I
D
YS
R
S
L
L
D
V
A
T
T
E
H
Q
I
G
Y
A
A
S
S
T
A
A
S
S
L
V
R
D
I
K
G
A
M
E
A
R
L
P
P
P
D
L
T
P
E
Q
L
R
S
R
-
S
W
W
T
G
A
E
L
F
L
V
V
D
D
Y
E
M
V
A
T
S
--
D
N
P
L
R
P
L
A
E
L
L
P
Q
A
R
D
I
G
L
H
L
I
I
A
R
S
M
G
G
A
G
R
A
L
Y
E
P
I
I
Q
R
I
K
E
M
-
A
S
P
G
L
V
M
S
G
N
-
K
D
E
G
I
-
L
L
G
N
V
K
P
H
K
L
P
Q
G
R
G
Y
F
V
E
R
R
-
S
G
---
T
R
L
I
Q
T
A
Y
R
E
S
--
21
HHSearch
69.69
24%
8
- C2 -
4NH0
5
?
A:
[246-1145]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-
A
N
M
T
L
T
S
L
L
H
I
D
----
N
P
Y
N
L
--
D
P
A
V
L
W
R
P
R
P
Q
R
N
R
L
R
V
P
I
G
L
D
-----
A
D
-----
G
R
P
L
E
L
D
I
K
E
SAQ
G
G
M
---
G
---
P
H
G
L
C
I
G
A
T
G
S
G
K
S
E
L
L
R
T
L
V
L
A
L
A
M
-----
T
H
S
P
E
V
L
N
F
V
L
V
D
F
K
G
G
A
T
F
L
G
M
E
G
L
R
H
V
S
A
-
I
-
I
T
N
L
E
E
E
L
P
L
V
D
R
M
Y
D
A
L
H
G
E
M
V
R
R
Q
-
E
H
L
R
H
S
-
G
N
Y
A
---
S
L
R
D
Y
E
K
---------------
A
R
M
E
G
---------------------
A
-
P
L
---------------------
P
P
M
-------
P
T
L
F
I
V
L
D
E
F
S
E
L
L
S
A
K
-
P
D
F
A
E
L
F
V
M
-
I
-
G
R
L
G
R
S
L
G
V
H
L
L
L
A
S
Q
R
L
E
-
E
G
-
K
L
R
G
L
D
T
H
L
S
Y
R
I
G
L
R
T
F
S
A
M
E
S
R
V
V
L
G
V
P
D
A
Y
E
L
--
P
P
S
P
-
G
N
G
---
Y
L
K
F
A
-------------
T
-
E
P
L
V
R
F
K
A
A
Y
V
--
S
G
P
-
V
D
E
E
-------------------------------
S
E
S
L
F
D
V
V
V
R
Q
L
A
-----
G
H
G
P
E
P
H
Q
I
---
W
L
P
P
L
D
V
P
P
T
L
D
-------
E
L
L
P
P
L
SPSAAHGYTADGWEWRG
R
L
H
A
V
V
G
L
V
D
R
P
F
D
Q
R
R
D
P
Y
W
L
D
L
-
S
G
G
A
G
H
V
G
V
A
G
G
P
Q
T
G
K
S
T
M
L
R
T
L
I
T
S
L
A
L
L
H
T
P
Q
E
V
Q
F
Y
C
L
D
F
G
G
G
T
L
A
G
L
A
E
L
P
H
V
G
S
V
A
T
R
L
D
A
D
R
I
R
R
T
V
A
E
V
S
A
L
L
E
Q
R
E
Q
E
F
T
E
R
G
I
D
S
M
A
T
Y
R
R
L
------
R
A
T
GEYA--------------------
G
------
D
G
F
G
D
V
F
L
V
V
D
N
W
L
T
L
R
Q
D
Y
-
E
A
L
E
D
S
I
T
Q
L
A
A
R
G
L
G
Y
G
I
H
V
V
L
S
S
N
K
W
S
--
E
F
---
R
--
T
S
I
R
-
D
L
L
G
T
--
K
L
E
L
R
L
G
D
P
Y
E
S
E
V
D
-
R
K
K
A
A
N
-
V
P
E
N
R
P
G
R
G
L
T
R
D
G
-----
Y
H
F
L
T
A
L
P
R
I
D
G
D
T
S
AE
T
L
T
E
G
-
I
A
T
T
V
K
T
I
R
E
A
W
H
G
-
P
T
A
P
P
V
R
M
L
P
N
V
L
P
A
A
Q
L
P
S
A
A
---
E
S
G
T
R
I
----
P
I
G
I
D
E
D
S
L
S
P
V
Y
L
D
F
N
T
D
P
H
F
-----
L
V
F
G
D
T
E
C
G
K
S
N
L
L
R
L
I
T
A
G
I
I
E
R
Y
TP
Q
Q
A
R
L
I
F
I
D
Y
S
R
--
S
L
L
D
V
A
T
T
-
E
H
Q
I
G
Y
A
A
S
S
T
A
A
S
S
L
V
R
D
I
K
G
A
M
E
A
R
L
P
P
P
D
L
T
P
E
Q
L
R
S
R
S
W
W
-
T
G
A
E
L
F
L
V
V
D
D
Y
E
M
V
A
T
S
--
D
N
P
L
R
P
L
A
E
L
L
P
Q
A
R
D
I
G
L
H
L
I
I
A
R
S
M
G
G
A
G
R
A
L
Y
E
P
I
I
Q
R
I
K
E
M
A
S
P
G
L
V
M
S
G
N
K
D
E
G
I
L
L
G
N
V
K
---
P
H
K
L
P
Q
G
R
G
Y
F
V
E
R
R
S
G
T
R
L
I
Q
T
A
Y
R
--------
3
PsiBlast_PDB
64.10
26%
6
- C2 -
4NH0
5
?
A:
[246-970]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-
A
N
M
T
L
T
S
L
L
H
I
D
----
N
P
Y
N
L
--
D
P
A
V
L
W
R
P
R
P
Q
R
N
R
L
R
V
P
I
G
L
D
-----
A
D
-----
G
R
P
L
E
L
D
I
K
E
---
S
A
Q
---
G
GMG
P
H
G
L
C
I
G
A
T
G
S
G
K
S
E
L
L
R
T
L
V
L
A
L
A
M
-----
T
H
S
P
E
V
L
N
F
V
L
V
D
F
K
G
G
A
T
F
L
G
M
E
G
L
R
H
V
S
A
-
I
-
I
T
N
L
E
E
E
L
P
L
V
D
R
M
Y
D
A
L
H
G
E
M
V
R
R
Q
E
H
L
R
H
S
G
-
N
-
Y
A
---
S
L
R
D
Y
E
K
---------------
A
R
M
E
G
---------------------
A
-
P
L
---------------------
P
P
M
-------
P
T
L
F
I
V
L
D
E
F
S
E
L
L
S
A
K
-
P
D
F
A
E
L
F
V
M
-
I
-
G
R
L
G
R
S
L
G
V
H
L
L
L
A
S
Q
R
L
E
-
E
G
-
K
L
R
G
L
D
T
H
L
S
Y
R
I
G
L
R
T
F
S
A
M
E
S
R
V
V
L
G
V
P
D
A
Y
E
L
--
P
-
P
S
P
G
N
G
---
Y
L
K
F
A
-------------
T
E
P
L
V
R
-
F
K
A
A
Y
V
--
S
G
P
-
V
D
E
E
---------------------------------
S
--
E
S
L
F
D
V
V
V
R
Q
L
A
G
H
G
----
P
E
P
HQI
W
L
P
P
L
--
D
V
P
P
T
L
D
E
L
L
PP
L
S
P
S
A
A
HGYTADGWEWRG-----
R
L
H
A
V
V
G
L
V
D
R
P
F
D
Q
R
R
D
P
Y
W
L
D
L
S
G
G
-
A
G
H
V
G
V
A
G
G
P
Q
T
G
K
S
T
M
L
R
T
L
I
T
S
L
A
L
L
H
T
P
Q
E
V
Q
F
Y
C
L
D
F
G
G
G
T
L
A
G
L
A
E
L
P
H
V
G
S
V
A
T
R
L
D
A
D
R
I
R
R
T
V
A
E
V
S
A
L
L
E
Q
R
E
Q
E
F
T
E
R
G
I
D
S
M
A
T
Y
R
R
L
R
A
T
GEY
A
--------------------------
G
------
D
G
F
G
D
V
F
L
V
V
D
N
W
L
T
L
R
Q
D
Y
-
E
A
L
E
D
S
I
T
Q
L
A
A
R
G
L
G
Y
G
I
H
V
V
L
S
S
N
K
W
S
--
E
F
---
R
--
T
S
I
R
-
D
L
L
G
T
--
K
L
E
L
R
L
G
D
P
Y
E
S
E
V
D
R
K
K
A
A
N
--
V
P
E
N
R
P
G
R
G
L
T
-
R
D
---
G
Y
H
F
L
T
A
L
P
R
I
D
G
D
T
S
A
--
E
T
L
T
E
G
I
A
T
T
V
K
T
I
R
E
A
W
H
G
P
T
A
P
-
P
V
R
M
L
P
N
V
L
P
A
A
Q
L
P
S
A
A
E
S
G
T
R
---
I
----
P
I
G
I
D
E
D
S
L
S
P
V
Y
L
D
F
N
T
D
P
H
F
-----
L
V
F
G
D
T
E
C
G
K
S
N
L
L
R
L
I
T
A
G
I
I
E
R
---
Y
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
48.14
18%
34
- C2 -
4NH0
5
?
A:
[290-1146]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
E
L
D
I
K
--
E
SAQGGMG
P
H
G
L
C
I
G
A
T
G
S
G
K
S
E
L
L
R
T
L
V
L
A
L
A
M
T
H
S
P
E
V
L
N
F
V
L
V
D
F
K
-
G
G
A
T
F
L
G
M
E
G
L
R
H
V
S
A
I
I
T
N
L
E
E
---
E
L
P
L
V
D
R
M
Y
D
A
L
H
G
E
M
V
R
R
Q
E
H
L
R
H
S
GNYAS
L
R
D
Y
E
K
A
R
M
E
G
A
P
L
P
P
M
P
T
L
F
I
V
L
D
E
F
S
E
L
L
S
A
K
PDF
A
E
L
F
V
M
I
G
R
L
G
R
S
L
G
V
H
L
L
L
A
S
Q
R
L
E
E
G
KL
R
GLD
T
H
L
S
Y
R
I
G
L
RT
F
S
A
M
--
E
S
R
V
V
LGVPDAYELPPSP
G
N
G
Y
L
K
F
A
T
E
P
L
V
R
F
K
A
A
Y
V
S
G
P
V
D
E
ESE
S
L
F
D
V
V
V
R
Q
L
A
G
H
-
G
P
E
P
H
-----
Q
IW
L
P
P
L
D
-
V
P
P
T
L
D
E
L
L
P
P
L
----
S
P
S
A
A
HG
Y
T
A
D
G
W
E
W
---
R
G
R
L
H
A
V
V
G
L
V
DRPFD
Q
R
-----
R
D
P
Y
W
L
D
L
S
G
-----
G
---
A
---
G
H
V
G
V
A
G
G
P
Q
T
G
K
S
T
M
L
R
T
L
I
T
S
L
A
L
-----
L
H
T
P
Q
E
V
Q
F
Y
C
L
D
F
G
G
G
-
T
L
A
G
L
A
E
L
P
H
V
G
S
-
V
-
A
T
R
L
D
A
D
R
--
I
R
R
T
V
A
E
V
S
A
L
L
E
Q
R
E
-
Q
E
F
T
E
R
-
G
-
I
D
---
S
M
A
T
Y
R
R
---------------
L
R
A
T
G
---------------------
E
Y
A
G
---------------------
D
G
F
-------
G
D
V
F
L
V
V
D
N
W
L
T
L
R
Q
D
Y
-
E
A
L
E
D
S
I
T
Q
-
L
-
A
A
R
G
L
G
Y
G
I
H
V
V
L
S
S
N
K
W
S
--
E
-
F
R
T
S
I
R
D
L
L
G
T
K
L
E
L
R
L
G
D
P
Y
E
S
E
V
D
-
R
K
-
K
A
A
N
V
PE
N
-
R
P
-
G
R
G
---
L
T
R
D
G
------------------
Y
H
F
L
T
A
L
P
--
R
I
D
-
G
D
T
S
A
-------------------------------
E
T
L
T
E
G
I
A
T
T
V
K
T
I
R
E
A
W
H
G
--
P
T
A
P
---
P
V
R
M
L
P
N
V
L
P
A
A
-------
Q
L
P
S
A
A
ES---------------
G
T
R
I
P
I
G
I
D
----
E
D
S
L
S
P
V
Y
L
D
F
-
N
T
-
D
P
H
F
L
V
F
G
D
T
E
C
G
K
S
N
L
L
R
L
I
T
A
G
I
I
E
R
Y
T
P
Q
Q
A
R
L
I
F
I
D
Y
S
R
S
-
L
L
D
V
A
T
T
E
H
Q
I
G
Y
A
--
A
S
S
T
A
A
S
S
L
V
R
D
I
K
G
A
M
E
A
R
L
P
P
P
D
L
----
T
P
E
Q
L
R
S
R
------
S
--------------------------
W
------
W
T
G
A
E
L
F
L
V
V
D
D
Y
E
M
V
A
T
S
--
D
N
P
L
R
P
L
A
E
L
L
P
Q
A
R
D
I
G
L
H
L
I
I
A
R
S
M
G
G
--
A
G
RAL
Y
--
E
P
I
I
-
Q
R
I
K
E
M
A
S
P
G
L
V
M
S
G
N
K
D
E
G
I
L
L
G
N
V
K
---
P
H
K
L
P
Q
G
R
G
Y
F
V
E
R
RS-
G
T
R
L
I
Q
T
A
Y
R
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
46.81
23%
10
- C2 -
2IUT
3
FTSK_PSEAE
A:
[70-477]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
P
P
L
S
L
L
D
P
A
E
V
K
Q
K
------
S
Y
S
P
E
S
L
--
E
---
A
M
S
R
L
L
E
I
K
--
L
K
E
F
G
V
E
-----------------
V
S
V
D
S
V
H
P
G
P
V
I
T
R
F
E
I
Q
P
A
A
G
-------
V
K
V
S
R
I
S
N
L
A
K
D
L
A
R
S
L
-
A
VI
S
V
R
V
--
V
E
V
I
P
G
K
T
T
V
G
I
E
I
P
N
E
D
R
Q
M
V
R
F
S
E
V
--
L
S
S
P
E
Y
D
E
H
K
S
T
--
V
P
L
A
L
G
H
D
-----
I
G
-----
G
R
P
I
I
T
D
L
A
K
---
M
---------
P
H
L
L
V
A
G
T
T
G
S
G
K
S
V
G
V
N
A
M
L
L
S
I
L
F
-----
K
S
T
P
S
E
A
R
L
I
M
I
D
P
K
M
L
E
L
S
-
I
Y
E
G
I
P
H
L
L
C
-
P
-
V
V
T
---
D
M
K
E
A
A
N
A
L
R
W
S
V
A
E
M
E
R
R
Y
-
R
L
M
A
A
M
-
G
-
V
R
---
N
L
A
G
F
N
R
---------------
K
V
K
D
A
---------------------
E
-
E
A
G
T
P
L
T
DPLFRRESPDDEPPQL
S
T
L
-------
P
T
I
V
V
V
V
D
E
F
A
D
M
M
M
I
V
-
G
K
K
V
E
E
L
I
A
-
R
I
A
Q
K
A
R
A
A
G
I
H
L
I
L
A
T
Q
R
P
S
V
D
V
-
I
T
G
L
I
K
A
N
I
P
T
R
I
A
F
Q
V
S
S
K
I
D
S
R
T
I
L
D
Q
G
G
A
E
Q
L
--
L
-
G
H
-
G
D
M
---
L
Y
L
P
P
-------------
G
T
G
L
P
I
R
V
H
G
A
F
V
--
S
D
D
-
E
V
H
R
V
V
E
A
W
K
L
R
G
A
P
D
Y
I
E
D
I
L
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Fugue
42.23
17%
19
- C1 -
3JB6
1
?
A:
[5-1224]
------------
T
K
L
H
N
T
I
F
S
E
T
R
K
F
T
-------
R
E
S
F
K
E
I
E
H
L
T
A
R
L
A
N
D
R
V
A
R
H
D
F
L
-----------
F
N
T
S
I
V
L
I
S
D
Y
S
G
E
D
S
N
----
G
N
Q
L
Q
A
T
I
T
I
P
---
N
E
I
I
N
P
K
E
Y
-------
D
P
S
D
Y
P
L
A
E
D
E
S
F
F
K
Q
G
H
K
Y
D
Y
L
V
T
F
-
R
A
G
S
L
T
N
T
Y
E
P
K
T
K
M
Y
K
L
H
A
A
L
D
K
L
M
H
V
K
Q
R
K
S
R
F
A
D
L
W
R
E
L
C
A
V
I
A
S
L
D
V
W
Y
Q
T
T
N
Y
P
L
R
T
Y
V
K
L
L
F
H
K
G
D
E
F
P
F
Y
E
S
P
S
Q
D
R
I
I
F
N
D
K
S
V
A
S
----------
I
L
P
T
F
V
Y
T
C
C
Q
V
G
T
A
I
M
S
--
G
I
L
T
H
V
E
S
I
V
A
M
N
H
F
L
H
C
A
K
D
S
Y
I
D
E
K
L
K
I
K
G
I
G
R
S
--
W
Y
Q
E
A
L
H
N
--------------
V
C
Q
A
T
V
P
V
W
S
Q
F
N
E
V
I
G
H
R
T
K
S
T
S
E
P
H
F
V
S
S
T
F
I
S
L
R
A
K
R
A
E
L
L
Y
-------------
P
E
F
N
A
Y
I
N
R
A
I
Q
L
S
K
T
Q
N
D
V
A
N
Y
Y
A
A
C
R
A
M
T
N
D
-------
G
T
F
L
A
T
L
T
-
E
L
S
L
D
A
A
V
F
P
R
I
E
Q
-------
H
L
V
T
R
P
A
V
L
M
S
N
T
R
H
E
----------
S
L
K
Q
K
Y
T
N
G
---
V
G
S
I
A
Q
S
Y
L
S
S
F
T
D
E
I
A
K
R
V
N
G
R
H
---------------------
H
D
E
A
W
L
N
F
L
T
T
S
R
I
V
M
Q
A
-
V
----
F
A
R
E
Y
R
T
P
E
R
I
F
K
S
L
K
A
P
I
K
L
V
E
R
Q
Q
S
--
D
---
R
R
----
Q
R
A
--
I
S
G
L
--
D
-----------------
N
D
R
L
F
L
S
----
F
M
P
Y
T
I
G
K
Q
I
Y
-------
E
L
N
D
N
A
A
Q
G
K
Q
--------------------------------
A
G
----
N
A
F
D
I
--
G
E
M
L
Y
W
-
T
S
Q
R
N
-------------------------
V
L
L
S
S
I
D
---
V
A
G
-----------
M
D
A
S
V
T
T
N
T
K
D
I
Y
N
T
F
V
L
D
V
A
S
K
CTVP
R
F
G
P
Y
Y
A
K
N
M
E
V
-
F
E
A
G
N
R
Q
S
Q
V
R
Y
V
----------------
N
A
A
W
Q
A
C
A
L
E
A
A
N
S
Q
T
S
T
-----
S
Y
-
E
-
S
E
IF
G
Q
V
K
N
A
E
G
---------------
T
Y
P
S
G
---------------------
R
-
A
D
---------------------
T
S
T
-------
H
H
T
V
L
L
Q
G
L
V
R
G
N
E
L
K
R
-
A
S
D
----------------
G
K
N
S
C
L
A
T
I
K
----
I
-
L
G
D
D
I
M
E
I
F
Q
G
S
E
S
D
T
Y
D
H
A
V
S
N
A
S
I
L
N
E
S
G
F
A
T
T
--
A
------------
E
L
S
-------------
Q
N
S
I
V
L
L
Q
Q
L
V
V
N
--
G
T
F
------
W
G
F
A
D
R
I
S
L
W
T
R
------
E
D
T
K
D
I
G
R
L
N
L
A
M
M
E
L
N
A
L
I
D
D
L
V
F
R
V
R
R
P
E
G
L
-
K
M
L
G
F
---
F
C
G
A
I
C
L
R
R
F
T
L
-------
S
V
D
N
K
L
-----------------
Y
D
S
T
Y
N
N
L
S
K
Y
M
T
L
T
K
-----
Y
D
K
-
N
P
-
D
S
D
----------
S
T
L
M
S
L
I
L
P
L
A
W
L
F
M
P
R
G
G
E
Y
P
A
Y
P
F
E
R
R
D
G
T
--------
F
T
E
D
E
S
M
---------
F
T
A
R
---
G
A
Y
K
R
R
L
L
Y
D
V
S
N
I
G
E
M
I
Q
Q
N
S
M
------
A
-----------------------------------------------
L
D
D
D
L
L
-
H
E
Y
G
F
T
G
A
L
L
L
I
D
---
L
N
I
L
D
L
I
D
E
V
K
K
E
--
D
I
---
S
--
P
V
K
V
-
S
E
L
A
T
--
S
L
E
Q
--------------------
L
G
K
L
G
E
R
E
K
S
R
R
A
---
A
S
D
L
K
I
R
G
H
A
L
S
--
N
D
I
--
V
Y
G
Y
G
-
L
Q
E
K
I
Q
K
-----
S
A
M
A
T
K
E
T
T
V
Q
S
K
R
V
S
S
R
L
H
D
V
I
V
A
K
T
R
D
Y
K
I
S
T
I
PAD
A
L
H
L
H
E
F
E
V
E
D
V
T
V
D
L
L
P
H
A
K
H
TSYSS
L
A
Y
N
M
S
F
G
S
D
G
W
F
A
F
A
L
L
G
G
L
-
D
R
---
S
A
N
L
L
R
L
D
V
A
S
I
--
R
G
N
Y
H
K
F
S
-
Y
D
D
P
V
F
K
Q
G
Y
K
I
Y
K
S
D
A
T
L
L
N
D
F
F
T
A
-----
I
S
A
G
P
K
E
Q
G
I
-
L
L
-
R
A
F
A
Y
Y
S
L
Y
G
N
V
-
E
Y
H
Y
V
L
S
P
R
Q
L
F
F
L
S
D
N
P
V
S
A
E
R
L
----
V
R
I
P
P
K
Y
Y
V
S
T
Q
-
C
R
A
L
Y
N
I
F
S
Y
L
--
H
I
L
R
S
I
A
N
N
-
R
G
-------
K
R
L
K
M
V
L
H
P
G
L
I
A
Y
V
-
R
G
-
T
S
Q
G
A
I
L
P
------
E
A
D
N
7
PsiBlast_PDB
41.25
28%
-7
- C2 -
2IUU
1
FTSK_PSEAE
A:
[212-477]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
---
M
---
P
H
L
L
V
A
G
T
T
G
S
G
K
S
V
G
V
N
A
M
L
L
S
I
L
F
-----
K
S
T
P
S
E
A
R
L
I
M
I
D
P
K
M
L
E
L
S
I
-
Y
E
G
I
P
H
L
L
C
P
V
-
V
T
D
M
K
E
A
A
N
----
A
L
R
W
S
V
A
E
M
E
R
R
Y
-
R
L
M
A
A
M
-
G
-
V
R
---
N
L
A
G
F
N
R
---------------
K
V
K
D
A
---------------------
E
-
E
A
G
T
P
L
T
DPLFRRESPDD
E
P
P
Q
L
S
T
L
-------
P
T
I
V
V
V
V
D
E
F
A
D
M
M
M
I
V
-
G
K
K
V
E
E
L
I
A
R
I
-
A
Q
K
A
R
A
A
G
I
H
L
I
L
A
T
Q
R
P
S
V
D
V
-
I
T
G
L
I
K
A
N
I
P
T
R
I
A
F
Q
V
S
S
K
I
D
S
R
T
I
L
D
Q
G
G
A
E
Q
L
-----
L
-
G
H
G
D
M
L
Y
L
P
P
G
TG
L
P
I
R
V
H
G
A
F
V
S
D
D
E
V
H
R
V
V
E
-
A
W
K
L
R
G
A
P
D
Y
I
E
D
I
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
41.13
28%
-7
- C2 -
2IUT
2
FTSK_PSEAE
A:
[212-478]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
---
M
---
P
H
L
L
V
A
G
T
T
G
S
G
K
S
V
G
V
N
A
M
L
L
S
I
L
F
-----
K
S
T
P
S
E
A
R
L
I
M
I
D
P
K
M
L
E
L
S
I
-
Y
E
G
I
P
H
L
L
C
P
V
-
V
T
D
M
K
E
A
A
N
----
A
L
R
W
S
V
A
E
M
E
R
R
Y
-
R
L
M
A
A
M
-
G
-
V
R
---
N
L
A
G
F
N
R
---------------
K
V
K
D
A
---------------------
E
-
E
A
G
T
P
L
T
DPLFRRESPDDEPPQL
S
T
L
-------
P
T
I
V
V
V
V
D
E
F
A
D
M
M
M
I
V
-
G
K
K
V
E
E
L
I
A
R
I
-
A
Q
K
A
R
A
A
G
I
H
L
I
L
A
T
Q
R
P
S
V
D
V
-
I
T
G
L
I
K
A
N
I
P
T
R
I
A
F
Q
V
S
S
K
I
D
S
R
T
I
L
D
Q
G
G
A
E
Q
L
-----
L
-
G
H
G
D
M
L
Y
L
P
P
G
TG
L
P
I
R
V
H
G
A
F
V
S
D
D
E
V
H
R
V
V
E
-
A
W
K
L
R
G
A
P
D
Y
I
E
D
I
L
A
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
41.12
27%
-27
- C2 -
2IUT
2
FTSK_PSEAE
A:
[193-455]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
P
L
A
L
G
H
D
-----
I
G
-----
G
R
P
I
I
T
D
L
A
------
K
---
M
---
P
H
L
L
V
A
G
T
T
G
S
G
K
S
V
G
V
N
A
M
L
L
S
I
L
F
-----
K
S
T
P
S
E
A
R
L
I
M
I
D
P
K
M
L
-
E
L
S
I
Y
E
G
I
P
H
L
L
C
P
V
-
V
T
D
M
K
E
----
A
A
N
A
L
R
W
S
V
A
E
M
E
R
R
Y
-
R
L
M
A
A
M
-
G
-
V
R
---
N
L
A
G
F
N
R
---------------
K
V
K
D
A
E
E
A
G
T
P
L
T
DPLFRRESPDDEP
P
-
Q
L
---------------------
S
T
L
-------
P
T
I
V
V
V
V
D
E
F
A
D
M
M
M
I
V
G
K
K
V
E
E
L
I
A
R
-
I
-
A
Q
K
A
R
A
A
G
I
H
L
I
L
A
T
Q
R
P
S
-
V
D
V
I
T
G
L
I
K
A
N
I
P
T
R
I
A
F
Q
V
S
S
K
I
D
S
R
T
I
L
D
Q
G
G
A
E
Q
L
--
L
-
G
H
-
G
D
M
---
L
Y
L
P
P
-------------
G
T
G
L
P
I
R
V
H
G
A
F
V
--
S
D
D
-
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
40.91
17%
-330
- C2 -
1JEK
2
A:
[1-40]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
L
A
N
A
T
A
A
Q
Q
E
V
L
E
A
S
Y
A
M
-
V
Q
H
I
A
K
G
I
R
I
L
E
A
R
V
A
R
V
E
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
40.27
28%
-24
- C2 -
2IUS
-
FTSK_ECOLI
A:
[962-1225]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
L
T
V
V
L
G
K
D
-----
I
A
-----
G
E
P
V
V
A
D
L
A
------
K
---
M
---
P
H
L
L
V
A
G
T
T
G
S
G
A
S
V
G
V
N
A
M
I
L
S
M
L
Y
-----
K
A
Q
P
E
D
V
R
F
I
M
I
D
P
K
M
L
-
E
L
S
V
Y
E
G
I
P
H
L
L
T
-
E
V
V
T
D
M
K
D
----
A
A
N
A
L
R
W
C
V
N
E
M
E
R
R
Y
-
K
L
M
S
A
L
-
G
-
V
R
---
N
L
A
G
Y
N
E
---------------
K
I
A
E
A
D
R
M
MRPIPDPYWH--------
P
-
V
L
---------------------
K
K
E
-------
P
Y
I
V
V
L
V
D
E
F
A
D
L
M
M
T
V
G
K
K
V
E
E
L
I
A
R
-
L
-
A
Q
K
A
R
A
A
G
I
H
L
V
L
A
T
Q
R
P
S
-
V
D
V
I
T
G
L
I
K
A
N
I
P
T
R
I
A
F
T
V
S
S
K
I
D
S
R
T
I
L
D
Q
A
G
A
E
S
L
--
L
-
G
M
-
G
D
M
---
L
Y
S
G
P
-------------
N
S
T
L
P
V
R
V
H
G
A
F
V
--
R
D
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
39.64
28%
-136
- C3 -
5FWH
-
?
A:
[2-194]
-
S
Q
L
W
V
L
Y
E
T
Y
C
Q
L
F
S
L
T
----
E
K
V
I
V
I
G
N
Q
L
E
H
H
V
T
V
S
S
F
S
F
R
N
G
Y
I
Q
I
E
K
K
S
--
S
T
L
A
V
L
Q
G
G
R
Q
I
G
E
L
K
P
R
C
S
I
T
I
D
V
---
Q
M
T
I
A
W
S
G
E
E
Q
R
K
Y
V
Y
Y
V
G
Q
Q
S
E
V
L
V
S
N
---------
D
P
Q
A
D
I
E
T
T
N
A
R
F
S
L
R
K
H
R
G
Q
W
V
V
I
P
D
D
D
A
P
L
F
L
N
G
V
Q
L
S
D
A
V
S
L
R
N
G
D
V
L
L
C
P
Y
M
Q
F
V
F
I
E
E
D
L
L
A
--
V
T
S
S
E
E
V
V
S
S
L
T
E
T
M
P
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
39.64
26%
4
- C2 -
4N1A
4
?
A:
[110-412]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
S
T
M
L
R
T
L
I
T
S
L
A
L
L
H
T
P
Q
E
V
Q
F
Y
C
L
D
F
G
G
G
T
L
A
G
L
A
E
L
P
H
V
G
S
V
A
T
R
L
D
A
D
R
I
R
R
T
V
A
E
V
S
A
L
L
E
Q
R
E
Q
E
F
T
E
R
G
I
D
S
M
A
T
Y
R
R
L
R
A
T
GEY
A
--------------------------
G
------
D
G
F
G
D
V
F
L
V
V
D
N
W
L
T
L
R
Q
D
Y
-
E
A
L
E
D
S
I
T
Q
L
A
A
R
G
L
G
Y
G
I
H
V
V
L
S
S
N
K
W
S
--
E
F
---
R
--
T
S
I
R
-
D
L
L
G
T
--
K
L
E
L
R
L
G
D
P
Y
E
S
E
V
D
R
K
K
A
A
N
--
V
P
E
N
R
P
G
R
G
L
T
-
R
D
---
G
Y
H
F
L
T
A
L
P
R
I
D
G
D
T
S
A
--
E
T
L
T
E
G
I
A
T
T
V
K
T
I
R
E
A
W
H
G
P
T
A
P
-
P
V
R
M
L
P
N
V
L
P
A
A
Q
L
P
---
S
A
A
E
S
G
T
R
I
----
P
I
G
I
D
E
D
S
L
S
P
V
Y
L
D
F
N
T
D
P
H
F
-----
L
V
F
G
D
T
E
C
G
K
S
N
L
L
R
L
I
T
A
G
I
I
E
R
---
Y
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
39.17
19%
22
- C2 -
4LYA
3
?
A:
[48-558]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
N
A
F
P
I
G
L
K
-----
D
E
PELQ
S
Q
S
D
Y
F
Y
Q
W
L
------
E
---
D
---
G
N
I
G
I
F
G
S
A
G
Y
G
K
S
T
T
M
M
T
L
L
L
S
F
A
G
-----
A
Y
N
P
A
Q
L
H
Y
Y
I
F
D
F
G
N
S
-
A
L
L
P
L
R
Q
L
P
H
T
A
D
-
Y
-
F
R
L
D
D
E
K
K
--
I
E
K
F
I
K
F
M
K
E
E
M
E
Q
R
K
-
Q
R
F
M
E
K
-
E
-
V
S
---
T
I
K
L
Y
N
A
---------------
L
S
---------------------------
E
---------------------
E
K
L
-------
P
I
I
I
V
A
L
D
N
F
D
V
V
K
E
E
M
-
P
D
F
E
T
Q
L
I
Q
-
Y
-
A
R
D
G
Q
S
L
G
I
F
F
I
M
T
A
T
R
V
S
--
G
-
I
R
P
P
L
M
N
N
L
K
T
K
I
V
H
Y
F
I
D
S
S
E
K
F
S
L
I
G
R
T
P
Y
D
V
D
--
P
-
I
P
-
G
R
A
---
L
I
K
K
D
-------------
N
---
A
A
L
T
Q
I
Y
L
P
--
A
D
G
-
E
D
---------------------------------
D
I
E
V
L
E
N
V
K
R
E
M
E
R
L
K
E
V
Y
Q
H
I
-
P
K
P
K
---
P
I
P
M
L
P
P
R
L
S
M
S
-------
V
F
T
N
T
Y
VQHRA------------
S
G
F
I
P
V
G
L
----
D
E
Q
T
V
R
P
V
A
I
N
M
-
R
T
-
D
P
H
C
L
I
V
G
Q
S
R
K
G
K
T
N
V
V
K
V
I
L
E
S
L
L
V
Q
-
E
--
P
E
S
I
G
L
L
D
G
I
D
R
G
L
A
G
Y
A
N
R
D
---
D
I
T
Y
I
E
A
K
E
R
L
A
Q
W
L
N
E
A
D
A
V
L
Q
Q
R
E
R
E
Y
I
Q
A
V
N
---------------------------------------------------
W
P
P
V
V
F
V
V
D
S
L
L
R
L
Q
Q
E
T
D
S
I
M
Q
G
R
I
A
N
M
M
K
Q
Y
S
H
L
G
F
H
V
F
V
A
G
N
A
N
E
--
F
V
---
K
GF
D
A
L
T
A
E
L
K
Q
I
--
R
Q
A
I
L
V
T
K
K
-
S
E
Q
S
L
F
A
L
P
F
T
RN
E
Q
E
I
E
P
G
F
G
Y
F
V
V
G
G--
K
D
Q
K
I
Q
I
P
K
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
38.20
15%
-61
- C2 -
2IUS
-
FTSK_ECOLI
A:
[965-1226]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
V
L
G
K
D
----
I
-
A
G
E
P
V
V
A
D
L
-
A
K
-
M
P
H
L
L
V
A
G
T
T
G
S
G
A
S
V
G
V
N
A
M
I
L
S
M
L
Y
K
A
Q
P
E
D
V
R
F
I
M
I
D
P
K
M
L
E
L
S
V
Y
E
G
I
P
H
L
L
T
E
V
-
V
T
D
M
K
D
A
A
N
A
L
R
W
C
V
N
E
M
E
R
R
Y
K
L
M
S
A
L
G
V
R
N
L
A
G
Y
N
E
K
------
I
A
E
A
D
R
M
MRPIPDPYWH
P
V
--------
L
------
K
K
E
P
Y
I
V
V
L
V
D
E
F
A
D
L
M
M
T
V
G
K
K
V
E
E
L
I
A
R
L
A
Q
K
A
R
A
A
G
I
H
L
V
L
A
T
Q
R
P
S
VD
V
I
---
T
--
G
L
I
K
-
A
N
I
P
T
--
R
I
A
F
T
V
S
S
K
I
D
S
R
T
I
L
D
Q
A
G
A
--
E
S
L
L
G
M
G
D
M
L
Y
S
G
P
NST
L
P
V
R
V
H
G
A
F
V
R
D
Q
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
36.69
28%
-45
- C2 -
2IUS
-
FTSK_ECOLI
A:
[969-1202]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
-----
D
I
A
G
E
P
V
V
A
D
---
L
A
K
---
M
---
P
H
L
L
V
A
G
T
T
G
S
G
A
S
V
G
V
N
A
M
I
L
S
M
L
Y
-----
K
A
Q
P
E
D
V
R
F
I
M
I
D
P
K
M
L
E
L
S
V
-
Y
E
G
I
P
H
L
L
T
E
V
-
V
T
D
M
K
D
A
A
N
----
A
L
R
W
C
V
N
E
M
E
R
R
Y
-
K
L
M
S
A
L
-
G
-
V
R
---
N
L
A
G
Y
N
E
K
I
A
E
A
D
R
M
MRPIPDP
Y
W
----------------------------------------------------H
P
V
L
K
KE
P
Y
I
V
V
L
V
D
E
F
A
D
L
M
M
T
V
-
G
K
K
V
E
E
L
I
A
R
L
-
A
Q
K
A
R
A
A
G
I
H
L
V
L
A
T
Q
R
P
S
V
D
V
-
I
T
G
L
I
K
A
N
I
P
T
R
I
A
F
T
V
S
S
K
I
D
S
R
T
I
L
D
Q
A
G
A
E
S
L
--
L
-
G
M
-
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
34.85
17%
-67
- C2 -
2IUT
2
FTSK_PSEAE
A:
[194-455]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
L
A
L
G
---
H
D
I
G
G
R
P
I
I
T
D
L
-
A
K
-
M
P
H
L
L
V
A
G
T
T
G
S
G
K
S
V
G
V
N
A
M
L
L
S
I
L
F
K
S
T
P
S
E
A
R
L
I
M
I
D
P
K
M
L
E
L
S
I
Y
E
G
I
P
H
L
L
C
P
V
-
V
T
D
M
K
E
A
A
N
A
L
R
W
S
V
A
E
M
E
R
R
Y
R
L
M
A
A
M
G
V
R
N
L
A
G
F
N
R
K
------
V
K
D
A
E
E
A
G
T
P
L
T
DPLFRRESPDDEPPQ
L
------
S
T
L
P
T
I
V
V
V
V
D
E
F
A
D
M
M
M
I
V
G
K
K
V
E
E
L
I
A
R
I
A
Q
K
A
R
A
A
G
I
H
L
I
L
A
T
Q
R
P
S
VD
V
I
---
T
--
G
L
I
K
-
A
N
I
P
T
--
R
I
A
F
Q
V
S
S
K
I
D
S
R
T
I
L
D
Q
G
G
A
--
E
Q
L
L
G
H
G
D
M
L
Y
L
P
P
GTG
L
P
I
R
V
H
G
A
F
V
S
D
D
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------