@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu32050: (2016-07-23 )
MFYAVQQSEHTETLVVGLFQKSQLTGKALEIDEMLEGHLTQLLKEGDVSAKPNQVSKVFPPSSAGMKRIYFVGLGREANYSFEQAKERFAHVFQAIHKDRKQETAVLLDTFISEDVPPADAAHALAESCLLASYEVQDYKHKSNEPDKQIEAVYVVTDEDTQEVQAGLRVGQAYGQGTNSARTLVNMPGNMLTATDLASYAEELAAKYDFECEILEKSEMEELGMGGILAVNQGSTEPPKMIVLKYQGKKEWEDVVGLVGKGITFDTGGYSIKTKSGIVGMKSDMGGAAAVLGAMETIGELRPEQNVLCVIPSTDNMISGGAMKPDDVIVSLSGKTIEILNTDAEGRLVLADGITYAKQHGASVLVDVATLTGGVVVALGTETTGAMTNDQSFYQQVADAAQECGEAIWQLPITEKDKKRVKSSQMADLSNSPGREGHAIMAGTFLGEFAESTPWVHLDIAGTATANKATCFGPAGATGVMARTLATLAERFTLEEDKNE
Atome Classification :
(20 SA)
-----......----...10......----..20........30....--....40....-----....50........60........70........80........90........100.......110.......120..----.....130.......140.....-..150....--...--160-.......170-.........180.......190.......200......--.---210.......220.......230.......240......-.250....--....260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.....-.-.390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----M
F
Y
A
VQ----QSEHT
E
T
L
V
V
G
----
L
F
Q
KSQLTGKA
L
E
I
D
E
M
L
--
E
G
H
L
T
Q
L
L
K
E-----GDVSAKPNQ
V
S
KVFPPSSAG
M
K
R
I
Y
F
V
GLGREANY
S
F
E
Q
A
K
E
R
F
A
H
V
F
Q
A
I
H
K
D
R
K
Q
E
T
A
V
L
L
D
T
F
I
SEDVP
P
A
D
A
A
H
A
----
L
A
E
S
C
L
L
A
S
Y
E
V
QDYKHKSNEPD-K
Q
I
E
A
V
Y
V
V--TDE--
D
T
Q
-
E
V
Q
A
G
L
R
V
---
G
Q
A
YGQGTNSA
R
T
L
VNMPGNM
L
T
A
T
D
L
A
S
Y
A
E
E
L
A
A
KY--D---F
E
C
E
IL
E
K
S
E
M
E
E
LGMG
G
I
L
A
VNQGSTEP
P
K
M
I
V
L
K
YQG-K
K
-
E
W
E
D
V
--
V
G
L
VGKG
I
T
FDTG
G
Y
S
I
KTKSGIVGMKSDMG
G
A
A
A
V
L
G
A
M
E
T
I
G
ELRPEQ
N
V
L
C
V
IPSTDNMISGGAMKPD
D
V
I
V
SLSG
K
T
I
E
I
L
NTDAE
G
R
L
V
L
ADG
I
T
Y
A
K
QHG
A
S
V
L
V
D
V
A
TLTG
G
V
V
V
A
L
GTETTGAM-T-N
D
Q
S
F
Y
Q
Q
V
A
D
A
A
Q
E
C
G
E
A
I
WQLPIT
E
K
D
K
K
R
V
K
S
S
Q
M
ADLSNSPGREG
H
A
I
M
A
G
T
F
L
G
E
F
AEST
P
W
V
H
L
DIAGTATANK
A
T
C
FGPAG
A
T
G
V
M
A
R
T
L
A
T
L
A
E
R
FTLEEDKNE
6
PsiBlast_PDB
80.76
34%
-27
- C4 -
1GYT
3
AMPA_ECOLI
A:
[11-491]
---------------
E
K
Q
R
S
A
C
I
V
V
G
----
V
F
E
P
R
R
L
S
P
I
A
E
Q
L
D
K
I
S
--
D
G
Y
I
S
A
L
L
R
R
-----
G
E
L
E
G
K
P
G
Q
T
L
L
L
H
H
V
P
N
V
L
S
E
R
I
L
L
I
G
C
G
K
E
R
E
L
D
E
R
Q
Y
K
Q
V
I
Q
K
T
I
N
T
L
N
D
T
G
S
M
E
A
V
C
F
L
T
E
L
H
V
K
G
R
N
N
Y
W
K
V
R
Q
----
A
V
E
T
A
K
E
T
L
Y
S
F
D
Q
L
K
T
N
K
S
E
P
R
-
R
P
L
R
K
M
-
V
F
--
N
V
P
--
T
R
R
-
E
L
T
S
G
E
R
A
I
Q
H
G
L
A
I
A
A
G
I
K
A
A
K
D
L
G
N
M
P
P
N
I
C
N
A
A
Y
L
A
S
Q
A
R
Q
L
A
D
S
Y
SK
N
---
V
I
T
R
V
I
G
E
Q
Q
M
K
E
L
G
M
H
S
Y
L
A
V
G
Q
G
S
Q
N
E
S
L
M
S
V
I
E
Y
K
G
-
N
A
-
S
-
E
D
A
R
P
I
V
L
V
G
K
G
L
T
F
D
S
G
G
I
S
I
K
P
S
E
G
M
D
E
M
K
Y
D
M
C
G
A
A
A
V
Y
G
V
M
R
M
V
A
E
L
Q
L
P
I
N
V
I
G
V
L
A
G
C
E
N
M
P
G
G
R
A
Y
R
P
G
D
V
L
T
T
M
S
G
Q
T
V
E
V
L
N
T
D
A
E
G
R
L
V
L
C
D
V
L
T
Y
V
E
R
F
E
P
E
A
V
I
D
V
A
T
L
T
G
A
C
V
I
A
L
G
H
H
I
T
G
L
M
-
A
-
N
H
N
P
L
A
H
E
L
I
A
A
S
E
Q
S
G
D
R
A
W
R
L
P
L
G
D
E
Y
Q
E
Q
L
E
S
N
-
F
A
D
M
A
N
I
G
G
R
P
G
G
A
I
T
A
G
C
F
L
S
R
F
T
R
K
Y
N
W
A
H
L
D
I
A
G
T
A
-------
W
R
S
G
K
A
K
G
A
T
G
R
P
V
A
L
L
A
Q
----------
53
PsiBlast_CBE
79.36
34%
-28
- C4 -
1GYT
3
AMPA_ECOLI
B:
[11-491]
---------------
E
K
Q
R
S
A
C
I
V
V
G
----
V
F
E
P
R
R
L
S
P
I
A
E
Q
L
D
K
I
S
--
D
G
Y
I
S
A
L
L
R
R
-----
G
E
L
E
G
K
P
G
Q
T
L
L
L
H
H
V
P
N
V
L
S
E
R
I
L
L
I
G
C
G
K
E
R
E
L
D
E
R
Q
Y
K
Q
V
I
Q
K
T
I
N
T
L
N
D
T
G
S
M
E
A
V
C
F
L
T
E
L
H
V
K
G
R
N
N
Y
W
K
V
R
Q
----
A
V
E
T
A
K
E
T
L
Y
S
F
D
Q
L
K
T
N
K
S
E
P
R
-
R
P
L
R
K
M
-
V
F
--
N
V
P
--
T
R
R
-
E
L
T
S
G
E
R
A
IQH
G
L
A
I
A
A
G
I
K
A
A
K
D
L
G
N
M
P
P
N
I
C
N
A
A
Y
L
A
S
Q
A
R
Q
L
A
D
S
Y
SK
N
---
V
I
T
R
V
I
G
E
Q
Q
M
K
E
L
G
M
H
S
Y
L
A
V
G
Q
G
S
Q
N
E
S
L
M
S
V
I
E
Y
K
G
-
N
A
-
S
-
E
D
A
RP
I
V
L
V
G
K
G
L
T
F
D
S
G
G
I
S
I
K
P
S
E
G
M
D
E
M
K
Y
D
M
C
G
A
A
A
V
Y
G
V
M
R
M
V
A
E
L
Q
L
P
I
N
V
I
G
V
L
A
G
C
E
N
M
P
G
G
R
A
Y
R
P
G
D
V
L
T
T
M
S
G
Q
T
V
E
V
L
N
T
D
A
E
G
R
L
V
L
C
D
V
L
T
Y
V
E
R
F
E
P
E
A
V
I
D
V
A
T
L
T
G
A
C
V
I
A
L
G
H
H
I
T
G
L
M
-
A
-
N
H
N
P
L
A
H
E
L
I
A
A
S
E
Q
S
G
D
R
A
W
R
L
P
L
G
D
E
Y
Q
E
Q
L
E
S
N
-
F
A
D
M
A
N
I
G
G
R
P
G
G
A
I
T
A
G
C
F
L
S
R
F
T
R
K
Y
N
W
A
H
L
D
I
A
G
T
A
-------
W
R
S
G
K
A
K
G
A
T
G
R
P
V
A
L
L
A
Q
----------
43
PsiBlast_CBE
78.83
34%
-26
- C4 -
1GYT
16
AMPA_ECOLI
L:
[11-491]
---------------
E
K
Q
R
S
A
C
I
V
V
G
----
V
F
E
P
R
R
L
S
P
I
A
E
Q
L
D
K
I
S
--
D
G
Y
I
S
A
L
L
R
R
-----
G
E
L
E
G
K
P
G
Q
T
L
L
L
H
H
V
P
N
V
L
S
E
R
I
L
L
I
G
C
G
K
E
R
E
L
D
E
R
Q
Y
K
Q
V
I
Q
K
T
I
N
T
L
N
D
T
G
S
M
E
A
V
C
F
L
T
E
L
H
V
K
G
R
N
N
Y
W
K
V
R
Q
----
A
V
E
T
A
K
E
T
L
Y
S
F
D
Q
L
K
T
N
K
S
E
P
R
-
R
P
L
R
K
M
-
V
F
--
N
V
P
--
T
R
R
-
E
L
T
S
G
E
R
A
IQH
G
L
A
I
A
A
G
I
K
A
A
K
D
L
G
N
M
P
P
N
I
C
N
A
A
Y
L
A
S
Q
A
R
Q
L
A
D
S
Y
SK
N
---
V
I
T
R
V
I
G
E
Q
Q
M
K
E
L
G
M
H
S
Y
L
A
V
G
Q
G
S
Q
N
E
S
L
M
S
V
I
E
Y
K
G
-
N
A
-
S
-
E
D
A
RP
I
V
L
V
G
K
G
L
T
F
D
S
G
G
I
S
I
K
P
S
E
G
M
D
E
M
K
Y
D
M
C
G
A
A
A
V
Y
G
V
M
R
M
V
A
E
L
Q
L
P
I
N
V
I
G
V
L
A
G
C
E
N
M
P
G
G
R
A
Y
R
P
G
D
V
L
T
T
M
S
G
Q
T
V
E
V
L
N
T
D
A
E
G
R
L
V
L
C
D
V
L
T
Y
V
E
R
F
E
P
E
A
V
I
D
V
A
T
L
T
G
A
C
V
I
A
L
G
H
H
I
T
G
L
M
-
A
-
N
H
N
P
L
A
H
E
L
I
A
A
S
E
Q
S
G
D
R
A
W
R
L
P
L
G
D
E
Y
Q
E
Q
L
E
S
N
-
F
A
D
M
A
N
I
G
G
R
P
G
G
A
I
T
A
G
C
F
L
S
R
F
T
R
K
Y
N
W
A
H
L
D
I
A
G
T
A
-------
W
R
S
G
K
A
K
G
A
T
G
R
P
V
A
L
L
A
Q
----------
52
PsiBlast_CBE
78.43
34%
-25
- C4 -
1GYT
3
AMPA_ECOLI
C:
[11-491]
---------------
E
K
Q
R
S
A
C
I
V
V
G
----
V
F
E
P
R
R
L
S
P
I
A
E
Q
L
D
K
I
S
--
D
G
Y
I
S
A
L
L
R
R
-----
G
E
L
E
G
K
P
G
Q
T
L
L
L
H
H
V
P
N
V
L
S
E
R
I
L
L
I
G
C
G
K
E
R
E
L
D
E
R
Q
Y
K
Q
V
I
Q
K
T
I
N
T
L
N
D
T
G
S
M
E
A
V
C
F
L
T
E
L
H
V
K
G
R
N
N
Y
W
K
V
R
Q
----
A
V
E
T
A
K
E
T
L
Y
S
F
D
Q
L
K
T
N
K
S
E
P
R
-
R
P
L
R
K
M
-
V
F
--
N
V
P
--
T
R
R
-
E
L
T
S
G
E
R
A
IQH
G
L
A
I
A
A
G
I
K
A
A
K
D
L
G
N
M
P
P
N
I
C
N
A
A
Y
L
A
S
Q
A
R
Q
L
A
D
S
Y
SK
N
---
V
I
T
R
V
I
G
E
Q
Q
M
K
E
L
G
M
H
S
Y
L
A
V
G
Q
G
S
Q
N
E
S
L
M
S
V
I
E
Y
K
G
-
N
A
-
S
-
E
D
A
RP
I
V
L
V
G
K
G
L
T
F
D
S
G
G
I
S
I
K
P
S
E
G
M
D
E
M
K
Y
D
M
C
G
A
A
A
V
Y
G
V
M
R
M
V
A
E
L
Q
L
P
I
N
V
I
G
V
L
A
G
C
E
N
M
P
G
G
R
A
Y
R
P
G
D
V
L
T
T
M
S
G
Q
T
V
E
V
L
N
T
D
A
E
G
R
L
V
L
C
D
V
L
T
Y
V
E
R
F
E
P
E
A
V
I
D
V
A
T
L
T
G
A
C
V
I
A
L
G
H
H
I
T
G
L
M
-
A
-
N
H
N
P
L
A
H
E
L
I
A
A
S
E
Q
S
G
D
R
A
W
R
L
P
L
G
D
E
Y
Q
E
Q
L
E
S
N
-
F
A
D
M
A
N
I
G
G
R
P
G
G
A
I
T
A
G
C
F
L
S
R
F
T
R
K
Y
N
W
A
H
L
D
I
A
G
T
A
-------
W
R
S
G
K
A
K
G
A
T
G
R
P
V
A
L
L
A
Q
----------
243
Fugue
78.36
34%
26
- C4 -
1GYT
3
AMPA_ECOLI
A:
[1-503]
-----
M
E
F
S
V
K
S
G
S
P
E
K
Q
R
S
A
C
I
V
V
G
----
V
F
E
P
R
R
L
S
P
I
A
E
Q
L
D
K
I
S
--
D
G
Y
I
S
A
L
L
R
R
-----
G
E
L
E
G
K
P
G
Q
T
L
L
L
H
H
V
P
N
V
L
S
E
R
I
L
L
I
G
C
G
K
E
R
E
L
D
E
R
Q
Y
K
Q
V
I
Q
K
T
I
N
T
L
N
D
T
G
S
M
E
A
V
C
F
L
T
E
L
H
V
K
G
R
N
N
Y
W
K
V
R
Q
----
A
V
E
T
A
K
E
T
L
Y
S
F
D
Q
L
K
T
N
K
S
E
P
R
-
R
P
L
R
K
M
V
F
N
V
P
T
R
R
--
E
L
T
-
S
G
E
R
A
I
Q
H
---
G
L
A
I
A
A
G
I
K
A
A
K
D
L
G
N
M
P
P
N
I
C
N
A
A
Y
L
A
S
Q
A
R
Q
L
A
D
S
Y
--
S
KN-
V
I
T
R
V
I
G
E
Q
Q
M
K
E
L
G
M
H
S
Y
L
A
V
G
Q
G
S
Q
N
E
S
L
M
S
V
I
E
Y
K
G
N
A
S
-
E
D
A
R
P
--
I
V
L
V
G
K
G
L
T
F
D
S
G
G
I
S
I
K
P
S
E
G
M
D
E
M
K
Y
D
M
C
G
A
A
A
V
Y
G
V
M
R
M
V
A
E
L
Q
L
P
I
N
V
I
G
V
L
A
G
C
E
N
M
P
G
G
R
A
Y
R
P
G
D
V
L
T
T
M
S
G
Q
T
V
E
V
L
N
T
D
A
E
G
R
L
V
L
C
D
V
L
T
Y
V
E
R
F
E
P
E
A
V
I
D
V
A
T
L
T
G
A
C
V
I
A
L
G
H
H
I
T
G
L
M
-
A
-
N
H
N
P
L
A
H
E
L
I
A
A
S
E
Q
S
G
D
R
A
W
R
L
P
L
G
D
E
Y
Q
E
Q
L
E
S
N
F
-
A
D
M
A
N
I
G
G
R
P
G
G
A
I
T
A
G
C
F
L
S
R
F
T
R
K
Y
N
W
A
H
L
D
I
A
G
T
A
W
R
S
G
----
K
A
K
G
A
T
G
R
P
V
A
L
L
A
Q
F
L
L
N
R
A
G
F
N
G
E
E
-
51
PsiBlast_CBE
78.34
34%
-26
- C4 -
1GYT
3
AMPA_ECOLI
D:
[11-491]
---------------
E
K
Q
R
S
A
C
I
V
V
G
----
V
F
E
P
R
R
L
S
P
I
A
E
Q
L
D
K
I
S
--
D
G
Y
I
S
A
L
L
R
R
-----
G
E
L
E
G
K
P
G
Q
T
L
L
L
H
H
V
P
N
V
L
S
E
R
I
L
L
I
G
C
G
K
E
R
E
L
D
E
R
Q
Y
K
Q
V
I
Q
K
T
I
N
T
L
N
D
T
G
S
M
E
A
V
C
F
L
T
E
L
H
V
K
G
R
N
N
Y
W
K
V
R
Q
----
A
V
E
T
A
K
E
T
L
Y
S
F
D
Q
L
K
T
N
K
S
E
P
R
-
R
P
L
R
K
M
-
V
F
--
N
V
P
--
T
R
R
-
E
L
T
S
G
E
R
A
IQH
G
L
A
I
A
A
G
I
K
A
A
K
D
L
G
N
M
P
P
N
I
C
N
A
A
Y
L
A
S
Q
A
R
Q
L
A
D
S
Y
SK
N
---
V
I
T
R
V
I
G
E
Q
Q
M
K
E
L
G
M
H
S
Y
L
A
V
G
Q
G
S
Q
N
E
S
L
M
S
V
I
E
Y
K
G
-
N
A
-
S
-
E
D
A
RP
I
V
L
V
G
K
G
L
T
F
D
S
G
G
I
S
I
K
P
S
E
G
M
D
E
M
K
Y
D
M
C
G
A
A
A
V
Y
G
V
M
R
M
V
A
E
L
Q
L
P
I
N
V
I
G
V
L
A
G
C
E
N
M
P
G
G
R
A
Y
R
P
G
D
V
L
T
T
M
S
G
Q
T
V
E
V
L
N
T
D
A
E
G
R
L
V
L
C
D
V
L
T
Y
V
E
R
F
E
P
E
A
V
I
D
V
A
T
L
T
G
A
C
V
I
A
L
G
H
H
I
T
G
L
M
-
A
-
N
H
N
P
L
A
H
E
L
I
A
A
S
E
Q
S
G
D
R
A
W
R
L
P
L
G
D
E
Y
Q
E
Q
L
E
S
N
-
F
A
D
M
A
N
I
G
G
R
P
G
G
A
I
T
A
G
C
F
L
S
R
F
T
R
K
Y
N
W
A
H
L
D
I
A
G
T
A
-------
W
R
S
G
K
A
K
G
A
T
G
R
P
V
A
L
L
A
Q
----------
50
PsiBlast_CBE
76.21
34%
-27
- C4 -
1GYT
2
AMPA_ECOLI
E:
[11-491]
---------------
E
K
Q
R
S
A
C
I
V
V
G
----
V
F
E
P
R
R
L
S
P
I
A
E
Q
L
D
K
I
S
--
D
G
Y
I
S
A
L
L
R
R
-----
G
E
L
E
G
K
P
G
Q
T
L
L
L
H
H
V
P
N
V
L
S
E
R
I
L
L
I
G
C
G
K
E
R
E
L
D
E
R
Q
Y
K
Q
V
I
Q
K
T
I
N
T
L
N
D
T
G
S
M
E
A
V
C
F
L
T
E
L
H
V
K
G
R
N
N
Y
W
K
V
R
Q
----
A
V
E
T
A
K
E
T
L
Y
S
F
D
Q
L
K
T
N
K
S
E
P
R
-
R
P
L
R
K
M
-
V
F
--
N
V
P
--
T
R
R
-
E
L
T
S
G
E
R
A
IQH
G
L
A
I
A
A
G
I
K
A
A
K
D
L
G
N
M
P
P
N
I
C
N
A
A
Y
L
A
S
Q
A
R
Q
L
A
D
S
Y
SK
N
---
V
I
T
R
V
I
G
E
Q
Q
M
K
E
L
G
M
H
S
Y
L
A
V
G
Q
G
S
Q
N
E
S
L
M
S
V
I
E
Y
K
G
-
N
A
-
S
-
E
D
A
RP
I
V
L
V
G
K
G
L
T
F
D
S
G
G
I
S
I
K
P
S
E
G
M
D
E
M
K
Y
D
M
C
G
A
A
A
V
Y
G
V
M
R
M
V
A
E
L
Q
L
P
I
N
V
I
G
V
L
A
G
C
E
N
M
P
G
G
R
A
Y
R
P
G
D
V
L
T
T
M
S
G
Q
T
V
E
V
L
N
T
D
A
E
G
R
L
V
L
C
D
V
L
T
Y
V
E
R
F
E
P
E
A
V
I
D
V
A
T
L
T
G
A
C
V
I
A
L
G
H
H
I
T
G
L
M
-
A
-
N
H
N
P
L
A
H
E
L
I
A
A
S
E
Q
S
G
D
R
A
W
R
L
P
L
G
D
E
Y
Q
E
Q
L
E
S
N
-
F
A
D
M
A
N
I
G
G
R
P
G
G
A
I
T
A
G
C
F
L
S
R
F
T
R
K
Y
N
W
A
H
L
D
I
A
G
T
A
-------
W
R
S
G
K
A
K
G
A
T
G
R
P
V
A
L
L
A
Q
----------
42
PsiBlast_CBE
74.83
36%
-55
- C4 -
3JRU
4
AMPA_XANOR
A:
[14-465]
----------------
S
A
A
V
D
C
I
V
V
G
----
A
F
A
D
K
T
L
S
P
A
A
Q
A
L
D
S
A
S
--
Q
G
R
L
T
A
L
L
A
R
-----
G
D
V
A
G
K
T
G
S
T
T
L
L
H
D
L
P
G
V
A
A
P
R
V
L
V
V
G
L
G
D
A
G
K
F
G
V
A
P
Y
L
K
A
I
G
D
A
T
R
A
L
---
K
T
G
A
V
G
T
A
L
L
T
L
T
E
L
T
V
K
A
R
D
A
A
W
N
----
I
R
Q
A
V
T
V
S
D
H
A
A
--
Y
R
Y
T
A
T
L
G
K
-
K
K
V
D
E
T
G
L
T
--
T
L
A
--
I
A
G
-
D
D
A
R
A
L
A
V
---
G
V
A
T
A
E
G
V
E
F
A
R
E
L
G
N
L
P
P
N
Y
C
T
P
A
Y
L
A
D
T
A
A
A
F
A
G
K
F
P-
G
---
A
E
A
E
I
L
D
E
A
Q
M
E
A
L
G
M
G
S
L
L
S
V
A
R
G
S
A
N
R
P
R
L
I
V
L
K
W
N
G
-
G
G
-
D
A
R
P
Y
--
V
-
L
V
G
K
G
I
T
F
D
T
G
G
V
N
L
K
T
Q
G
G
I
E
E
M
K
Y
D
M
C
G
G
A
T
V
I
G
T
F
V
A
T
V
K
A
E
L
P
I
N
L
V
V
V
V
P
A
V
E
N
A
I
D
G
N
A
Y
R
P
S
D
V
I
T
S
M
S
G
K
T
I
E
V
G
N
T
D
A
E
G
R
L
I
L
C
D
A
L
T
Y
A
E
R
F
N
P
E
A
L
V
D
V
A
T
L
T
G
A
C
M
V
A
L
G
H
Q
T
A
G
L
M
-
S
-
K
H
D
D
L
A
N
E
L
L
A
A
G
E
H
V
F
D
R
A
W
R
L
P
L
W
D
E
Y
Q
G
L
L
D
S
T
-
F
A
D
V
Y
N
I
G
G
R
W
G
G
A
I
T
A
G
C
F
L
S
R
F
T
E
N
Q
R
W
A
H
L
D
I
A
G
V
A
S
-----------------------------------
256
HHSearch
73.56
33%
21
- C4 -
1GYT
3
AMPA_ECOLI
A:
[12-500]
----------------
K
Q
R
S
A
C
I
V
V
G
----
V
F
E
P
R
R
L
S
-----
P
I
A
E
Q
--
L
D
K
I
S
D
G
Y
I
S
A
L
L
R
R
G
E
L
E
G
K
P
G
Q
T
L
L
L
H
H
V
P
N
V
L
S
E
R
I
L
L
I
G
C
G
K
E
R
E
L
D
E
R
Q
Y
K
Q
V
I
Q
K
T
I
N
T
L
N
D
T
G
S
M
E
A
V
C
F
L
T
E
L
H
V
K
G
R
N
N
Y
W
K
V
R
Q
----
A
V
E
T
A
K
E
T
L
Y
S
F
D
Q
L
K
T
N
K
S
E
P
R
R
P
L
-
R
K
M
V
F
N
--
V
P
T
RR
E
L
T
-
S
G
E
R
A
I
Q
H
---
G
L
A
I
A
A
G
I
K
A
A
K
D
L
G
N
M
P
P
N
I
C
N
A
A
Y
L
A
S
Q
A
R
Q
L
A
D
S
Y
SK
N
---
V
I
T
R
V
I
G
E
Q
Q
M
K
E
L
G
M
H
S
Y
L
A
V
G
Q
G
S
Q
N
E
S
L
M
S
V
I
E
Y
K
G
-
N
A
S
E
D
A
R
P
--
I
V
L
V
G
K
G
L
T
F
D
S
G
G
I
S
I
K
P
S
E
G
M
D
E
M
K
Y
D
M
C
G
A
A
A
V
Y
G
V
M
R
M
V
A
E
L
Q
L
P
I
N
V
I
G
V
L
A
G
C
E
N
M
P
G
G
R
A
Y
R
P
G
D
V
L
T
T
M
S
G
Q
T
V
E
V
L
N
T
D
A
E
G
R
L
V
L
C
D
V
L
T
Y
V
E
R
F
E
P
E
A
V
I
D
V
A
T
L
T
G
A
C
V
I
A
L
G
H
H
I
T
G
L
M
-
A
-
N
H
N
P
L
A
H
E
L
I
A
A
S
E
Q
S
G
D
R
A
W
R
L
P
L
G
D
E
Y
Q
E
Q
L
-
E
S
N
F
A
D
M
A
N
I
G
G
R
P
G
G
A
I
T
A
G
C
F
L
S
R
F
T
R
K
Y
N
W
A
H
L
D
I
A
G
T
A
W
R
S
G
----
K
A
K
G
A
T
G
R
P
V
A
L
L
A
Q
F
L
L
N
R
A
G
F
N
----
30
PsiBlast_CBE
73.47
35%
19
- C4 -
3KZW
1
?
C:
[34-508]
----------------
S
N
E
I
N
T
L
I
I
G
IPEH
L
N
Q
L
E
R
I
S
F
N
H
I
D
I
T
E
S
L
--
E
----
R
L
K
H
Q
-----
H
I
I
G
S
K
V
G
K
I
Y
T
T
A
F
D
V
Q
D
Q
T
Y
R
L
I
T
V
G
L
G
N
L
K
T
R
S
Y
Q
D
M
L
K
I
W
G
H
L
F
Q
Y
I
K
S
E
H
I
E
D
T
Y
L
L
M
D
S
F
I
S
K
Y
D
Q
L
S
D
V
L
M
A
----
C
G
I
Q
S
E
R
A
T
Y
E
F
D
H
Y
K
S
S
K
K
A
P
F
-
K
T
N
L
N
L
I
S
E
--
S
L
I
--
E
L
D
-
F
I
H
E
G
I
S
I
---
G
Q
S
----
I
N
L
A
R
D
F
S
N
M
P
P
N
V
L
T
P
---
Q
T
F
A
E
D
I
V
N
H
F
--
K
NTK
V
K
V
D
V
K
D
Y
D
T
L
V
S
E
G
F
G
L
L
Q
A
V
G
K
G
S
K
H
K
P
R
L
V
T
I
T
Y
N
G
-
K
D
-
K
D
E
A
P
--
I
A
L
V
G
K
G
I
T
Y
D
S
G
G
Y
S
I
K
T
K
N
G
M
A
T
M
K
F
D
M
C
G
A
A
N
V
V
G
I
I
E
A
A
S
R
L
Q
L
P
V
N
I
V
G
V
L
A
C
A
E
N
M
I
N
E
A
S
M
K
P
D
D
V
F
T
A
L
S
G
E
T
V
E
V
M
N
T
D
A
E
G
R
L
V
L
A
D
A
V
F
Y
A
N
Q
Y
Q
P
S
V
I
M
D
F
A
T
L
T
G
A
A
I
V
A
L
G
D
D
K
A
A
A
F
E
S
-
N
S
K
V
I
L
N
D
I
L
Q
I
S
S
E
V
D
E
M
V
F
E
L
P
I
T
A
T
E
R
A
S
I
K
H
S
D
I
A
D
L
V
N
H
T
N
G
Q
G
K
A
L
F
A
A
S
F
V
T
H
F
S
G
Q
T
P
H
I
H
F
D
I
A
G
P
A
T
T
N
K
A
S
Y
N
G
P
K
G
P
T
G
F
M
I
P
T
I
---------------
253
HHSearch
73.42
35%
5
- C4 -
3KZW
6
?
A:
[36-514]
------------------
E
I
N
T
L
I
I
G
----
I
P
E
H
L
N
Q
L
E
R
I
S
---
F
N
H
ID
I
T
E
S
L
E
R
L
K
H
Q
----
H
I
I
G
S
K
V
G
K
I
Y
T
T
A
F
D
V
Q
D
Q
T
Y
R
L
I
T
V
G
L
G
N
L
K
T
R
S
Y
Q
D
M
L
K
I
W
G
H
L
F
Q
Y
I
K
S
E
H
I
E
D
T
Y
L
L
M
D
S
F
I
S
K
Y
D
Q
L
S
D
V
L
M
A
----
C
G
I
Q
S
E
R
A
T
Y
E
F
D
H
Y
K
S
S
K
K
A
P
F
-
K
--
T
N
L
N
L
I
--
S
E
----
S
L
-
I
E
L
D
F
I
H
E
---
G
I
S
I
G
Q
S
I
N
L
A
R
D
F
S
N
M
P
P
N
V
L
T
P
Q
T
F
A
E
D
I
V
N
H
F
K
N
T
--
K
---
V
K
V
D
V
K
D
Y
D
T
L
V
S
E
G
F
G
L
L
Q
A
V
G
K
G
S
K
H
K
P
R
L
V
T
I
T
Y
N
G
-
K
D
-
K
D
E
A
P
--
I
A
L
V
G
K
G
I
T
Y
D
S
G
G
Y
S
I
K
T
K
N
G
M
A
T
M
K
F
D
M
C
G
A
A
N
V
V
G
I
I
E
A
A
S
R
L
Q
L
P
V
N
I
V
G
V
L
A
C
A
E
N
M
I
N
E
A
S
M
K
P
D
D
V
F
T
A
L
S
G
E
T
V
E
V
M
N
T
D
A
E
G
R
L
V
L
A
D
A
V
F
Y
A
N
Q
Y
Q
P
S
V
I
M
D
F
A
T
L
T
G
A
A
I
V
A
L
G
D
D
K
A
A
A
F
E
S
-
N
S
K
V
I
L
N
D
I
L
Q
I
S
S
E
V
D
E
M
V
F
E
L
P
I
T
A
T
E
R
A
S
I
K
H
S
D
I
A
D
L
V
N
H
T
N
G
Q
G
K
A
L
F
A
A
S
F
V
T
H
F
S
G
Q
T
P
H
I
H
F
D
I
A
G
P
A
T
T
N
K
A
S
Y
N
G
P
K
G
P
T
G
F
M
I
P
T
I
V
Q
W
L
K
Q
---------
4
PsiBlast_PDB
73.05
36%
12
- C4 -
3H8G
10
AMPA_PSEPU
F:
[12-469]
----------------
S
V
K
T
A
T
L
V
I
P
----
V
G
E
N
R
K
L
G
A
V
A
K
A
V
D
L
A
S
--
E
G
A
I
S
A
V
L
K
R
-----
G
D
L
A
G
K
P
G
Q
T
L
L
L
Q
N
L
Q
G
L
K
A
E
R
V
L
L
V
G
S
G
K
D
E
A
L
G
D
R
T
W
R
K
L
V
A
S
V
A
G
V
L
K
G
L
N
G
A
D
A
V
L
A
L
D
D
V
A
V
N
N
---
R
D
A
H
Y
G
KYRL
L
A
E
T
L
L
D
G
E
Y
V
F
D
R
F
K
S
Q
K
V
E
P
--
R
A
L
K
K
V
T
L
L
--
A
D
K
--
A
G
Q
A
E
V
E
R
A
V
K
H
---
A
S
A
I
A
T
G
M
A
F
T
R
D
L
G
N
L
P
P
N
L
C
H
P
S
F
L
A
E
Q
A
K
E
L
G
K
A
H
--
K
A--
L
K
V
E
V
L
D
E
K
K
I
K
D
L
G
M
G
A
F
Y
A
V
G
Q
G
S
D
Q
P
P
R
L
I
V
L
N
Y
Q
G
-
G
K
-
K
A
D
K
P
--
F
V
L
V
G
K
G
I
T
F
D
T
G
G
I
S
L
K
P
G
A
G
M
D
E
M
K
Y
D
M
C
G
A
A
S
V
F
G
T
L
R
A
V
L
E
L
Q
L
P
V
N
L
V
C
L
L
A
C
A
E
N
M
P
S
G
G
A
T
R
P
G
D
I
V
T
T
M
S
G
Q
T
V
E
I
L
N
T
D
A
E
G
R
L
V
L
C
D
T
L
T
Y
A
E
R
F
K
P
Q
A
V
I
D
I
A
T
L
T
G
A
C
I
V
A
L
G
S
H
T
T
G
L
M
-
G
-
N
N
D
D
L
V
G
Q
L
L
D
A
G
K
R
A
D
D
R
A
W
Q
L
P
L
F
D
E
Y
Q
E
Q
L
-
D
S
P
F
A
D
M
G
N
I
G
G
P
K
A
G
T
I
T
A
G
C
F
L
S
R
F
A
K
A
Y
N
W
A
H
M
D
I
A
G
T
A
------------------------------------
23
PsiBlast_CBE
72.88
35%
18
- C4 -
3KZW
24
?
J:
[34-508]
----------------
S
N
E
I
N
T
L
I
I
G
IPEH
L
N
Q
L
E
R
I
S
F
N
H
I
D
I
T
E
S
L
--
E
----
R
L
K
H
Q
-----
H
I
I
G
S
K
V
G
K
I
Y
T
T
A
F
D
V
Q
D
Q
T
Y
R
L
I
T
V
G
L
G
N
L
K
T
R
S
Y
Q
D
M
L
K
I
W
G
H
L
F
Q
Y
I
K
S
E
H
I
E
D
T
Y
L
L
M
D
S
F
I
S
K
Y
D
Q
L
S
D
V
L
M
A
----
C
G
I
Q
S
E
R
A
T
Y
E
F
D
H
Y
K
S
S
K
K
A
P
F
-
K
T
N
L
N
L
I
S
E
--
S
L
I
--
E
L
D
-
F
I
H
E
G
I
S
I
---
G
Q
S
----
I
N
L
A
R
D
F
S
N
M
P
P
N
V
L
T
P
---
Q
T
F
A
E
D
I
V
N
H
F
--
K
NTK
V
K
V
D
V
K
D
Y
D
T
L
V
S
E
G
F
G
L
L
Q
A
V
G
K
G
S
K
H
K
P
R
L
V
T
I
T
Y
N
G
-
K
D
-
K
D
E
A
P
--
I
A
L
V
G
K
G
I
T
Y
D
S
G
G
Y
S
I
K
T
K
N
G
M
A
T
M
K
F
D
M
C
G
A
A
N
V
V
G
I
I
E
A
A
S
R
L
Q
L
P
V
N
I
V
G
V
L
A
C
A
E
N
M
I
N
E
A
S
M
K
P
D
D
V
F
T
A
L
S
G
E
T
V
E
V
M
N
T
D
A
E
G
R
L
V
L
A
D
A
V
F
Y
A
N
Q
Y
Q
P
S
V
I
M
D
F
A
T
L
T
G
A
A
I
V
A
L
G
D
D
K
A
A
A
F
E
S
-
N
S
K
V
I
L
N
D
I
L
Q
I
S
S
E
V
D
E
M
V
F
E
L
P
I
T
A
T
E
R
A
S
I
K
H
S
D
I
A
D
L
V
N
H
T
N
G
Q
G
K
A
L
F
A
A
S
F
V
T
H
F
S
G
Q
T
P
H
I
H
F
D
I
A
G
P
A
T
T
N
K
A
S
Y
N
G
P
K
G
P
T
G
F
M
I
P
T
I
---------------
41
PsiBlast_CBE
72.66
36%
11
- C4 -
3H8F
4
AMPA_PSEPU
B:
[12-469]
----------------
S
V
K
T
A
T
L
V
I
P
----
V
G
E
N
R
K
L
G
A
V
A
K
A
V
D
L
A
S
--
E
G
A
I
S
A
V
L
K
R
-----
G
D
L
A
G
K
P
G
Q
T
L
L
L
Q
N
L
Q
G
L
K
A
E
R
V
L
L
V
G
S
G
K
D
E
A
L
G
D
R
T
W
R
K
L
V
A
S
V
A
G
V
L
K
G
L
N
G
A
D
A
V
L
A
L
D
D
V
A
V
N
N
---
R
D
A
H
Y
G
KYRL
L
A
E
T
L
L
D
G
E
Y
V
F
D
R
F
K
S
Q
K
V
E
P
--
R
A
L
K
K
V
T
L
L
--
A
D
K
--
A
G
Q
A
E
V
E
R
A
V
K
H
---
A
S
A
I
A
T
G
M
A
F
T
R
D
L
G
N
L
P
P
N
L
C
H
P
S
F
L
A
E
Q
A
K
E
L
G
K
A
H
--
K
A--
L
K
V
E
V
L
D
E
K
K
I
K
D
L
G
M
G
A
F
Y
A
V
G
Q
G
S
D
Q
P
P
R
L
I
V
L
N
Y
Q
G
-
G
K
-
K
A
D
K
P
--
F
V
L
V
G
K
G
I
T
F
D
T
G
G
I
S
L
K
P
G
A
G
M
D
E
M
K
Y
D
M
C
G
A
A
S
V
F
G
T
L
R
A
V
L
E
L
Q
L
P
V
N
L
V
C
L
L
A
C
A
E
N
M
P
S
G
G
A
T
R
P
G
D
I
V
T
T
M
S
G
Q
T
V
E
I
L
N
T
D
A
E
G
R
L
V
L
C
D
T
L
T
Y
A
E
R
F
K
P
Q
A
V
I
D
I
A
T
L
T
G
A
C
I
V
A
L
G
S
H
T
T
G
L
M
-
G
-
N
N
D
D
L
V
G
Q
L
L
D
A
G
K
R
A
D
D
R
A
W
Q
L
P
L
F
D
E
Y
Q
E
Q
L
-
D
S
P
F
A
D
M
G
N
I
G
G
P
K
A
G
T
I
T
A
G
C
F
L
S
R
F
A
K
A
Y
N
W
A
H
M
D
I
A
G
T
A
------------------------------------
21
PsiBlast_CBE
72.65
35%
19
- C4 -
3KZW
24
?
L:
[34-508]
----------------
S
N
E
I
N
T
L
I
I
G
IPEH
L
N
Q
L
E
R
I
S
F
N
H
I
D
I
T
E
S
L
--
E
----
R
L
K
H
Q
-----
H
I
I
G
S
K
V
G
K
I
Y
T
T
A
F
D
V
Q
D
Q
T
Y
R
L
I
T
V
G
L
G
N
L
K
T
R
S
Y
Q
D
M
L
K
I
W
G
H
L
F
Q
Y
I
K
S
E
H
I
E
D
T
Y
L
L
M
D
S
F
I
S
K
Y
D
Q
L
S
D
V
L
M
A
----
C
G
I
Q
S
E
R
A
T
Y
E
F
D
H
Y
K
S
S
K
K
A
P
F
-
K
T
N
L
N
L
I
S
E
--
S
L
I
--
E
L
D
-
F
I
H
E
G
I
S
I
---
G
Q
S
----
I
N
L
A
R
D
F
S
N
M
P
P
N
V
L
T
P
---
Q
T
F
A
E
D
I
V
N
H
F
--
K
NTK
V
K
V
D
V
K
D
Y
D
T
L
V
S
E
G
F
G
L
L
Q
A
V
G
K
G
S
K
H
K
P
R
L
V
T
I
T
Y
N
G
-
K
D
-
K
D
E
A
P
--
I
A
L
V
G
K
G
I
T
Y
D
S
G
G
Y
S
I
K
T
K
N
G
M
A
T
M
K
F
D
M
C
G
A
A
N
V
V
G
I
I
E
A
A
S
R
L
Q
L
P
V
N
I
V
G
V
L
A
C
A
E
N
M
I
N
E
A
S
M
K
P
D
D
V
F
T
A
L
S
G
E
T
V
E
V
M
N
T
D
A
E
G
R
L
V
L
A
D
A
V
F
Y
A
N
Q
Y
Q
P
S
V
I
M
D
F
A
T
L
T
G
A
A
I
V
A
L
G
D
D
K
A
A
A
F
E
S
-
N
S
K
V
I
L
N
D
I
L
Q
I
S
S
E
V
D
E
M
V
F
E
L
P
I
T
A
T
E
R
A
S
I
K
H
S
D
I
A
D
L
V
N
H
T
N
G
Q
G
K
A
L
F
A
A
S
F
V
T
H
F
S
G
Q
T
P
H
I
H
F
D
I
A
G
P
A
T
T
N
K
A
S
Y
N
G
P
K
G
P
T
G
F
M
I
P
T
I
---------------
5
PsiBlast_PDB
72.63
36%
-55
- C4 -
3JRU
4
AMPA_XANOR
B:
[14-465]
----------------
S
A
A
V
D
C
I
V
V
G
----
A
F
A
D
K
T
L
S
P
A
A
Q
A
L
D
S
A
S
--
Q
G
R
L
T
A
L
L
A
R
-----
G
D
V
A
G
K
T
G
S
T
T
L
L
H
D
L
P
G
V
A
A
P
R
V
L
V
V
G
L
G
D
A
G
K
F
G
V
A
P
Y
L
K
A
I
G
D
A
T
R
A
L
---
K
T
G
A
V
G
T
A
L
L
T
L
T
E
L
T
V
K
A
R
D
A
A
W
N
----
I
R
Q
A
V
T
V
S
D
H
A
A
--
Y
R
Y
T
A
T
L
G
K
-
K
K
V
D
E
T
G
L
T
--
T
L
A
--
I
A
G
-
D
D
A
R
A
L
A
V
---
G
V
A
T
A
E
G
V
E
F
A
R
E
L
G
N
L
P
P
N
Y
C
T
P
A
Y
L
A
D
T
A
A
A
F
A
G
K
F
P-
G
---
A
E
A
E
I
L
D
E
A
Q
M
E
A
L
G
M
G
S
L
L
S
V
A
R
G
S
A
N
R
P
R
L
I
V
L
K
W
N
G
-
G
G
-
D
A
R
P
Y
--
V
-
L
V
G
K
G
I
T
F
D
T
G
G
V
N
L
K
T
Q
G
G
I
E
E
M
K
Y
D
M
C
G
G
A
T
V
I
G
T
F
V
A
T
V
K
A
E
L
P
I
N
L
V
V
V
V
P
A
V
E
N
A
I
D
G
N
A
Y
R
P
S
D
V
I
T
S
M
S
G
K
T
I
E
V
G
N
T
D
A
E
G
R
L
I
L
C
D
A
L
T
Y
A
E
R
F
N
P
E
A
L
V
D
V
A
T
L
T
G
A
C
M
V
A
L
G
H
Q
T
A
G
L
M
-
S
-
K
H
D
D
L
A
N
E
L
L
A
A
G
E
H
V
F
D
R
A
W
R
L
P
L
W
D
E
Y
Q
G
L
L
D
S
T
-
F
A
D
V
Y
N
I
G
G
R
W
G
G
A
I
T
A
G
C
F
L
S
R
F
T
E
N
Q
R
W
A
H
L
D
I
A
G
V
A
S
-----------------------------------
245
Fugue
72.58
33%
35
- C4 -
3KZW
6
?
A:
[22-515]
SNA
M
N
F
K
L
N
N
T
----
L
S
N
E
I
N
T
L
I
I
G
----
I
P
E
H
L
N
Q
L
E
R
I
S
F
N
H
I
D
I
--
T
E
S
L
E
R
L
K
H
Q
-----
H
I
I
G
S
K
V
G
K
I
Y
T
T
A
F
D
V
Q
D
Q
T
Y
R
L
I
T
V
G
L
G
N
L
K
T
R
S
Y
Q
D
M
L
K
I
W
G
H
L
F
Q
Y
I
K
S
E
H
I
E
D
T
Y
L
L
M
D
S
F
I
S
K
Y
D
Q
L
S
D
V
L
M
A
----
C
G
I
Q
S
E
R
A
T
Y
E
F
D
H
Y
K
S
S
K
K
A
P
F
-
K
----
T
N
L
N
--
L
I
S
--
E
S
L
-
I
E
L
D
F
I
H
E
---
G
I
S
I
G
Q
S
I
N
L
A
R
D
F
S
N
M
P
P
N
V
L
T
P
Q
T
F
A
E
D
I
V
N
H
F
K
N
T
--
K
---
V
K
V
D
V
K
D
Y
D
T
L
V
S
E
G
F
G
L
L
Q
A
V
G
K
G
S
K
H
K
P
R
L
V
T
I
T
Y
N
G
-
K
D
-
K
D
E
A
P
--
I
A
L
V
G
K
G
I
T
Y
D
S
G
G
Y
S
I
K
T
K
N
G
M
A
T
M
K
F
D
M
C
G
A
A
N
V
V
G
I
I
E
A
A
S
R
L
Q
L
P
V
N
I
V
G
V
L
A
C
A
E
N
M
I
N
E
A
S
M
K
P
D
D
V
F
T
A
L
S
G
E
T
V
E
V
M
N
T
D
A
E
G
R
L
V
L
A
D
A
V
F
Y
A
N
Q
Y
Q
P
S
V
I
M
D
F
A
T
L
T
G
A
A
I
V
A
L
G
D
D
K
A
A
A
F
-
E
S
N
S
K
V
I
L
N
D
I
L
Q
I
S
S
E
V
D
E
M
V
F
E
L
P
I
T
A
T
E
R
A
S
I
K
H
S
D
I
A
D
L
V
N
H
T
N
G
Q
G
K
A
L
F
A
A
S
F
V
T
H
F
S
G
Q
T
P
H
I
H
F
D
I
A
G
P
A
T
T
N
K
A
S
Y
N
G
P
K
G
P
T
G
F
M
I
P
T
I
V
Q
W
L
K
Q
Q
--------
22
PsiBlast_CBE
72.28
35%
19
- C4 -
3KZW
24
?
K:
[34-508]
----------------
S
N
E
I
N
T
L
I
I
G
IPEH
L
N
Q
L
E
R
I
S
F
N
H
I
D
I
T
E
S
L
--
E
----
R
L
K
H
Q
-----
H
I
I
G
S
K
V
G
K
I
Y
T
T
A
F
D
V
Q
D
Q
T
Y
R
L
I
T
V
G
L
G
N
L
K
T
R
S
Y
Q
D
M
L
K
I
W
G
H
L
F
Q
Y
I
K
S
E
H
I
E
D
T
Y
L
L
M
D
S
F
I
S
K
Y
D
Q
L
S
D
V
L
M
A
----
C
G
I
Q
S
E
R
A
T
Y
E
F
D
H
Y
K
S
S
K
K
A
P
F
-
K
T
N
L
N
L
I
S
E
--
S
L
I
--
E
L
D
-
F
I
H
E
G
I
S
I
---
G
Q
S
----
I
N
L
A
R
D
F
S
N
M
P
P
N
V
L
T
P
---
Q
T
F
A
E
D
I
V
N
H
F
--
K
NTK
V
K
V
D
V
K
D
Y
D
T
L
V
S
E
G
F
G
L
L
Q
A
V
G
K
G
S
K
H
K
P
R
L
V
T
I
T
Y
N
G
-
K
D
-
K
D
E
A
P
--
I
A
L
V
G
K
G
I
T
Y
D
S
G
G
Y
S
I
K
T
K
N
G
M
A
T
M
K
F
D
M
C
G
A
A
N
V
V
G
I
I
E
A
A
S
R
L
Q
L
P
V
N
I
V
G
V
L
A
C
A
E
N
M
I
N
E
A
S
M
K
P
D
D
V
F
T
A
L
S
G
E
T
V
E
V
M
N
T
D
A
E
G
R
L
V
L
A
D
A
V
F
Y
A
N
Q
Y
Q
P
S
V
I
M
D
F
A
T
L
T
G
A
A
I
V
A
L
G
D
D
K
A
A
A
F
E
S
-
N
S
K
V
I
L
N
D
I
L
Q
I
S
S
E
V
D
E
M
V
F
E
L
P
I
T
A
T
E
R
A
S
I
K
H
S
D
I
A
D
L
V
N
H
T
N
G
Q
G
K
A
L
F
A
A
S
F
V
T
H
F
S
G
Q
T
P
H
I
H
F
D
I
A
G
P
A
T
T
N
K
A
S
Y
N
G
P
K
G
P
T
G
F
M
I
P
T
I
---------------
36
PsiBlast_CBE
72.04
36%
13
- C4 -
3H8G
5
AMPA_PSEPU
A:
[12-469]
----------------
S
V
K
T
A
T
L
V
I
P
----
V
G
E
N
R
K
L
G
A
V
A
K
A
V
D
L
A
S
--
E
G
A
I
S
A
V
L
K
R
-----
G
D
L
A
G
K
P
G
Q
T
L
L
L
Q
N
L
Q
G
L
K
A
E
R
V
L
L
V
G
S
G
K
D
E
A
L
G
D
R
T
W
R
K
L
V
A
S
V
A
G
V
L
K
G
L
N
G
A
D
A
V
L
A
L
D
D
V
A
V
N
N
---
R
D
A
H
Y
G
K
Y
R
L
L
A
E
T
L
L
D
G
E
Y
V
F
D
R
F
K
S
Q
K
V
E
P
--
R
A
L
K
K
V
T
L
L
--
A
D
K
--
A
G
Q
A
E
V
E
R
A
V
K
H
---
A
S
A
I
A
T
G
M
A
F
T
R
D
L
G
N
L
P
P
N
L
C
H
P
S
F
L
A
E
Q
A
K
E
L
G
K
A
H
--
K
A--
L
K
V
E
V
L
D
E
K
K
I
K
D
L
G
M
G
A
F
Y
A
V
G
Q
G
S
D
Q
P
P
R
L
I
V
L
N
Y
Q
G
-
G
K
-
K
A
D
K
P
--
F
V
L
V
G
K
G
I
T
F
D
T
G
G
I
S
L
K
P
G
A
G
M
D
E
M
K
Y
D
M
C
G
A
A
S
V
F
G
T
L
R
A
V
L
E
L
Q
L
P
V
N
L
V
C
L
L
A
C
A
E
N
M
P
S
G
G
A
T
R
P
G
D
I
V
T
T
M
S
G
Q
T
V
E
I
L
N
T
D
A
E
G
R
L
V
L
C
D
T
L
T
Y
A
E
R
F
K
P
Q
A
V
I
D
I
A
T
L
T
G
A
C
I
V
A
L
G
S
H
T
T
G
L
M
-
G
-
N
N
D
D
L
V
G
Q
L
L
D
A
G
K
R
A
D
D
R
A
W
Q
L
P
L
F
D
E
Y
Q
E
Q
L
-
D
S
P
F
A
D
M
G
N
I
G
G
P
K
A
G
T
I
T
A
G
C
F
L
S
R
F
A
K
A
Y
N
W
A
H
M
D
I
A
G
T
A
------------------------------------
1
PsiBlast_PDB
72.03
35%
18
- C4 -
3KZW
6
?
A:
[34-508]
----------------
S
N
E
I
N
T
L
I
I
G
I
P
EH
L
N
Q
L
E
R
I
S
F
N
H
I
D
I
T
E
S
L
--
E
----
R
L
K
H
Q
-----
H
I
I
G
S
K
V
G
K
I
Y
T
T
A
F
D
V
Q
D
Q
T
Y
R
L
I
T
V
G
L
G
N
L
K
T
R
S
Y
Q
D
M
L
K
I
W
G
H
L
F
Q
Y
I
K
S
E
H
I
E
D
T
Y
L
L
M
D
S
F
I
S
K
Y
D
Q
L
S
D
V
L
M
A
----
C
G
I
Q
S
E
R
A
T
Y
E
F
D
H
Y
K
S
S
K
K
A
P
F
-
K
T
N
L
N
L
I
S
E
--
S
L
I
--
E
L
D
-
F
I
H
E
G
I
S
I
---
G
Q
S
----
I
N
L
A
R
D
F
S
N
M
P
P
N
V
L
T
P
---
Q
T
F
A
E
D
I
V
N
H
F
--
K
NTK
V
K
V
D
V
K
D
Y
D
T
L
V
S
E
G
F
G
L
L
Q
A
V
G
K
G
S
K
H
K
P
R
L
V
T
I
T
Y
N
G
-
K
D
-
K
D
E
A
P
--
I
A
L
V
G
K
G
I
T
Y
D
S
G
G
Y
S
I
K
T
K
N
G
M
A
T
M
K
F
D
M
C
G
A
A
N
V
V
G
I
I
E
A
A
S
R
L
Q
L
P
V
N
I
V
G
V
L
A
C
A
E
N
M
I
N
E
A
S
M
K
P
D
D
V
F
T
A
L
S
G
E
T
V
E
V
M
N
T
D
A
E
G
R
L
V
L
A
D
A
V
F
Y
A
N
Q
Y
Q
P
S
V
I
M
D
F
A
T
L
T
G
A
A
I
V
A
L
G
D
D
K
A
A
A
F
E
S
-
N
S
K
V
I
L
N
D
I
L
Q
I
S
S
E
V
D
E
M
V
F
E
L
P
I
T
A
T
E
R
A
S
I
K
H
S
D
I
A
D
L
V
N
H
T
N
G
Q
G
K
A
L
F
A
A
S
F
V
T
H
F
S
G
Q
T
P
H
I
H
F
D
I
A
G
P
A
T
T
N
K
A
S
Y
N
G
P
K
G
P
T
G
F
M
I
P
T
I
---------------