@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu32520: (2016-07-24 )
MSGRRELCTPLRTIMTPGPVEVDPRVLRVMSTPVVGQFDPAFTGIMNETMEMLRELFQTKNRWAYPIDGTSRAGIEAVLASVIEPEDDVLIPIYGRFGYLLTEIAERYGANVHMLECEWGTVFDPEDIIREIKKVKPKIVAMVHGETSTGRIHPLKAIGEACRTEDALFIVDAVATIGGCEVKVDEWKIDAAIGGTQKCLSVPSGMAPITYNERVADVIAARKKVERGIATQADRAALSGNRPITSNYFDLSQLEDYWSERRLNHHTEATTMLYALREGVRLVLEEGLETRFERHRHHEAALAAGIKAMGLRLFGDDSCKMPVVTCVEIPGGIDGESVRDMLLAQFGIEIASSFGPLAGKIWRIGTMGYSCRKENVLFVLAGLEAVLLRHNAGIEAGKALQAALDVYENAGRQAAV
Atome Classification :
(34 SA)
.........10........20........30........40........50........-60..-......70-........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250....---..---.260.......270.......280.......290.......300.......310..-.....320.......330.......340........350.......360.......370-.-.......380.......390.......400.......410....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MS
G
R
R
E
L
C
T
P
L
R
T
IMTPGPVEV
D
P
R
V
L
R
V
MSTPVVGQF
D
P
A
F
T
G
I
M
N
E
T
M
E
M
L
R
E
L
F
QT-KN
R
W
-AYPIDGTS-R
A
G
I
E
A
V
L
A
S
V
IEPED
D
V
L
I
P
I
Y
G
R
F
G
Y
L
L
T
E
I
A
E
R
YGA
N
V
H
M
L
E
CEWGTVF
D
P
E
D
I
I
R
E
I
K
KVK
P
K
I
V
A
M
V
HGETSTGRI
H
P
L
K
A
I
G
E
A
CRTE
D
A
L
F
I
V
D
A
V
ATIGG
C
E
V
K
V
D
E
W
K
I
D
AAIGG
T
Q
K
C
L
SVPSGMAPITY
N
E
R
V
A
D
V
I
A
A
R
K
K
V
E
RGIATQA
D
R
AALSGNRPITSNYF
D
L
S
Q
L
E
D
---
Y
W
---
S
E
RRLNHH
T
E
A
T
T
M
L
Y
A
L
R
E
G
V
R
L
V
L
E
E
G
L
E
T
R
F
E
R
H
R
H
H
E
A
A
L
A
A
G
I
K
A
M
G
L
R
L
F-GDDSCK
M
P
V
V
T
C
V
EIPGGI
D
G
E
S
V
R
D
M
-
L
L
A
Q
F
G
I
E
I
A
SSFGPLAGK
I
W
R
I
GTMGYS-C-R-KE
N
V
L
F
V
L
A
G
L
E
A
V
L
L
RHNAGIE
A
G
K
A
L
Q
A
A
L
D
V
Y
E
NAGRQAAV
21
PsiBlast_CBE
93.46
100%
-134
- C1 -
3ISL
2
PUCG_BACSU
B:
[5-409]
----
R
E
L
C
T
P
L
R
T
I
M
T
P
G
P
V
E
V
D
P
R
V
L
R
V
M
S
T
P
V
V
G
Q
F
D
P
A
F
T
G
I
M
N
E
T
M
E
M
L
R
E
L
F
Q
T
-
K
N
R
W
-
A
Y
P
I
D
G
T
S
-
R
A
G
I
E
A
V
L
A
S
V
I
E
P
E
D
D
V
L
I
P
I
Y
G
R
F
G
Y
L
L
T
E
I
A
E
R
Y
G
A
N
V
H
M
L
E
C
E
W
G
T
V
F
D
P
E
D
I
I
R
E
I
K
K
V
K
P
K
I
V
A
M
V
H
G
E
T
S
T
G
R
I
H
P
L
K
A
I
G
E
A
C
R
T
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D
A
L
F
I
V
D
A
V
A
T
I
G
G
C
E
V
K
V
D
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W
K
I
D
A
A
I
G
G
T
Q
K
C
L
S
V
P
S
G
M
A
P
I
T
Y
N
E
R
V
A
D
V
I
A
A
R
------------------
N
R
P
I
T
S
N
Y
F
D
L
S
Q
L
E
D
---
Y
W
---
S
E
R
R
L
N
H
H
T
E
A
T
T
M
L
Y
A
L
R
E
G
V
R
L
V
L
E
E
G
L
E
T
R
F
E
R
H
R
H
H
E
A
A
L
A
A
G
I
K
A
M
G
L
R
L
F
-
G
D
D
S
C
K
M
P
V
V
T
C
V
E
I
P
G
G
I
D
G
E
S
V
R
D
M
-
L
L
A
Q
F
G
I
E
I
A
S
S
F
G
P
L
A
G
K
I
W
R
I
G
T
M
G
Y
S
-
C
-
R
-
K
E
N
V
L
F
V
L
A
G
L
E
A
V
L
L
R
H
N
A
G
I
E
A
G
K
A
L
Q
A
A
L
D
V
Y
E
N
-------
1
PsiBlast_PDB
93.23
100%
-135
- C1 -
3ISL
2
PUCG_BACSU
A:
[5-409]
----
R
E
L
C
T
P
L
R
T
I
M
T
P
G
P
V
E
V
D
P
R
V
L
R
V
M
S
T
P
V
V
G
Q
F
D
P
A
F
T
G
I
M
N
E
T
M
E
M
L
R
E
L
F
Q
T
-
K
N
R
W
-
A
Y
P
I
D
G
T
S
-
R
A
G
I
E
A
V
L
A
S
V
I
E
P
E
D
D
V
L
I
P
I
Y
G
R
F
G
Y
L
L
T
E
I
A
E
R
Y
G
A
N
V
H
M
L
E
C
E
W
G
T
V
F
D
P
E
D
I
I
R
E
I
K
K
V
K
P
K
I
V
A
M
V
H
G
E
T
S
T
G
R
I
H
P
L
K
A
I
G
E
A
C
R
T
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D
A
L
F
I
V
D
A
V
A
T
I
G
G
C
E
V
K
V
D
E
W
K
I
D
A
A
I
G
G
T
Q
K
C
L
S
V
P
S
G
M
A
P
I
T
Y
N
E
R
V
A
D
V
I
A
A
R
------------------
N
R
P
I
T
S
N
Y
F
D
L
S
Q
L
E
D
---
Y
W
---
S
E
R
R
L
N
H
H
T
E
A
T
T
M
L
Y
A
L
R
E
G
V
R
L
V
L
E
E
G
L
E
T
R
F
E
R
H
R
H
H
E
A
A
L
A
A
G
I
K
A
M
G
L
R
L
F
-
G
D
D
S
C
K
M
P
V
V
T
C
V
E
I
P
G
G
I
D
G
E
S
V
R
D
M
-
L
L
A
Q
F
G
I
E
I
A
S
S
F
G
P
L
A
G
K
I
W
R
I
G
T
M
G
Y
S
-
C
-
R
-
K
E
N
V
L
F
V
L
A
G
L
E
A
V
L
L
R
H
N
A
G
I
E
A
G
K
A
L
Q
A
A
L
D
V
Y
E
N
-------
49
HHSearch
78.97
98%
-32
- C1 -
3ISL
2
PUCG_BACSU
A:
[5-409]
----
R
E
L
C
T
P
L
R
T
I
M
T
P
G
P
V
E
V
D
P
R
V
L
R
V
M
S
T
P
V
V
G
Q
F
D
P
A
F
T
G
I
M
N
E
T
M
E
M
L
R
E
L
F
Q
T
-
K
N
R
--
W
A
Y
P
I
D
G
T
S
R
A
G
I
E
A
V
L
A
S
V
I
E
P
E
D
D
V
L
I
P
I
Y
G
R
F
G
Y
L
L
T
E
I
A
E
R
Y
G
A
N
V
H
M
L
E
C
E
W
G
T
V
F
D
P
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D
I
I
R
E
I
K
K
V
K
P
K
I
V
A
M
V
H
G
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T
S
T
G
R
I
H
P
L
K
A
I
G
E
A
C
R
T
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A
L
F
I
V
D
A
V
A
T
I
G
G
C
E
V
K
V
D
E
W
K
I
D
A
A
I
G
G
T
Q
K
C
L
S
V
P
S
G
M
A
P
I
T
Y
N
E
R
V
A
D
V
I
A
A
R
------------------
N
R
P
I
T
S
N
Y
F
D
L
S
Q
L
E
D
---
Y
W
---
S
E
R
R
L
N
H
H
T
E
A
T
T
M
L
Y
A
L
R
E
G
V
R
L
V
L
E
E
G
L
E
T
R
F
E
R
H
R
H
H
E
A
A
L
A
A
G
I
K
A
M
G
L
R
L
F
-
G
D
D
S
C
K
M
P
V
V
T
C
V
E
I
P
G
G
I
D
G
E
S
V
R
D
M
-
L
L
A
Q
F
G
I
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I
A
S
S
F
G
P
L
A
G
K
I
W
R
I
G
T
M
G
Y
S
-
C
-
R
K
E
N
-
V
L
F
V
L
A
G
L
E
A
V
L
L
R
H
N
A
G
I
E
A
G
K
A
L
Q
A
A
L
D
V
Y
E
N
-------
2
PsiBlast_PDB
77.44
50%
-113
- C1 -
3NNK
-
?
A:
[8-409]
-----
Q
L
N
P
P
S
R
L
L
M
G
P
G
P
I
N
A
D
P
R
V
L
R
A
M
S
S
Q
L
I
G
Q
Y
D
P
A
M
T
H
Y
M
N
E
V
M
A
L
Y
R
G
V
F
R
T
-
E
N
R
W
-
T
M
L
V
D
G
T
S
-
R
A
G
I
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A
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A
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D
K
V
L
V
P
V
F
G
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F
G
H
L
L
C
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I
A
R
R
C
R
A
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H
T
I
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W
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A
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L
L
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Q
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T
T
M
L
Q
P
L
A
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L
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Y
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A
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F
Y
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A
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L
G
G
N
P
L
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V
W
G
L
D
A
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S
A
G
M
Q
K
C
L
G
G
P
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G
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L
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A
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M
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K
C
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I
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D
A
H
R
D
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--
D
E
E
M
I
Y
S
N
Y
F
D
L
G
M
V
M
D
---
Y
W
---
G
P
E
R
L
N
H
H
T
E
A
T
T
A
L
F
G
A
R
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C
A
R
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I
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Y
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I
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K
G
I
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A
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G
L
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F
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G
D
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K
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K
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N
N
V
L
G
V
V
I
P
Q
G
I
N
G
D
Q
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K
L
-
M
L
E
D
F
G
I
E
I
G
T
S
F
G
P
L
H
G
K
V
W
R
I
G
T
M
G
Y
N
-
A
-
R
-
K
D
C
V
M
T
T
L
S
A
L
E
A
V
L
N
Y
L
K
F
P
T
T
Q
G
A
A
M
Q
A
A
W
D
H
Y
R
S
-------
3
PsiBlast_PDB
71.87
35%
-127
- C1 -
1VJO
1
?
A:
[30-392]
------
L
E
V
P
S
R
L
L
L
G
P
G
P
S
N
A
H
P
S
V
L
Q
A
M
N
V
S
P
V
G
H
L
D
P
A
F
L
A
L
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D
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L
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Y
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W
Q
T
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P
L
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T
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A
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A
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A
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A
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L
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G
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G
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L
L
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D
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L
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G
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L
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A
W
G
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D
L
A
Y
S
C
S
Q
K
G
L
G
C
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P
G
A
S
P
F
T
M
S
S
R
A
I
E
K
L
Q
R
R
R
T
------------------
K
V
A
N
W
Y
L
D
M
N
L
L
G
K
---
Y
W
---
G
S
E
R
V
Y
H
H
T
A
P
I
N
L
Y
Y
A
L
R
E
A
L
R
L
I
A
Q
E
G
L
A
N
C
W
Q
R
H
Q
K
N
V
E
Y
L
W
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R
L
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D
I
G
L
S
L
H
-
V
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K
E
Y
R
L
P
T
L
T
T
V
C
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P
D
G
V
D
G
K
A
V
A
R
R
-
L
L
N
E
H
N
I
E
V
G
G
G
L
G
E
L
A
G
K
V
W
R
V
G
L
M
G
F
N
-
S
-
R
-
K
E
S
V
D
Q
L
I
P
A
L
E
Q
V
L
-----------------------------
60
HHSearch
69.64
38%
-109
- C1 -
1VJO
1
?
A:
[30-392]
------
L
E
V
P
S
R
L
L
L
G
P
G
P
S
N
A
H
P
S
V
L
Q
A
M
N
V
S
P
V
G
H
L
D
P
A
F
L
A
L
M
D
E
I
Q
S
L
L
R
Y
V
W
Q
T
-
E
N
P
L
-
T
I
A
V
S
G
T
G
-
T
A
A
M
E
A
T
I
A
N
A
V
E
P
G
D
V
V
L
I
G
V
A
G
Y
F
G
N
R
L
V
D
M
A
G
R
Y
G
A
D
V
R
T
I
S
K
P
W
G
E
V
F
S
L
E
E
L
R
T
A
L
E
T
H
R
P
A
I
L
A
L
V
H
A
E
T
S
T
G
A
R
Q
P
L
E
G
V
G
E
L
C
R
E
F
G
T
L
L
L
V
D
T
V
T
S
L
G
G
V
P
I
F
L
D
A
W
G
V
D
L
A
Y
S
C
S
Q
K
G
L
G
C
S
P
G
A
S
P
F
T
M
S
S
R
A
I
E
K
L
Q
R
R
R
T
K
V
A
N
W
------------------
Y
L
D
M
N
L
L
G
K
---
Y
W
---
G
S
E
R
V
Y
H
H
T
A
P
I
N
L
Y
Y
A
L
R
E
A
L
R
L
I
A
Q
E
G
L
A
N
C
W
Q
R
H
Q
K
N
V
E
Y
L
W
E
R
L
E
D
I
G
L
S
L
H
-
V
E
K
E
Y
R
L
P
T
L
T
T
V
C
I
P
D
G
V
D
G
K
A
V
A
R
R
L
L
N
-
E
H
N
I
E
V
G
G
G
L
G
E
L
A
G
K
V
W
R
V
G
L
M
G
F
N
-
S
-
R
K
E
S
-
V
D
Q
L
I
P
A
L
E
Q
V
L
-----------------------------
37
PsiBlast_CBE
68.83
31%
-95
- C1 -
4I8A
6
SPYA_HUMAN
D:
[18-386]
----
K
P
L
S
I
P
N
Q
L
L
L
G
P
G
P
S
N
L
P
P
R
I
M
A
A
G
G
L
Q
M
I
G
S
M
S
K
D
M
Y
Q
I
M
D
E
I
K
E
G
I
Q
Y
V
F
Q
T
-
R
N
P
L
-
T
L
V
I
S
G
S
G
-
H
C
A
L
E
A
A
L
V
N
V
L
E
P
G
D
S
F
L
V
G
A
N
G
I
W
G
Q
R
A
V
D
I
G
E
R
I
G
A
R
V
H
P
M
T
K
D
P
G
G
H
Y
T
L
Q
E
V
E
E
G
L
A
Q
H
K
P
V
L
L
F
L
T
H
G
E
S
S
T
G
V
L
Q
P
L
D
G
F
G
E
L
C
H
R
Y
K
C
L
L
L
V
D
S
V
A
F
L
G
G
T
P
L
Y
M
D
R
Q
G
I
D
I
L
Y
S
G
S
Q
K
A
L
N
A
P
P
G
T
S
L
I
S
F
S
D
K
A
K
K
K
M
Y
S
R
K
-----------------
T
K
P
F
-
S
F
Y
L
D
I
K
W
L
A
N
---
F
W
GCD
D
Q
P
R
M
Y
H
H
T
I
P
V
I
S
L
Y
S
L
R
E
S
L
A
L
I
A
E
Q
G
L
E
N
S
W
R
Q
H
R
E
A
A
A
Y
L
H
G
R
L
Q
A
L
G
L
Q
L
F
V
K
D
P
A
L
R
L
P
T
V
T
T
V
A
V
P
A
G
Y
D
W
R
D
I
V
S
Y
-
V
I
D
H
F
D
I
E
I
M
G
G
L
G
P
S
T
G
K
V
L
R
I
G
L
L
G
C
N
-
A
-
T
-
R
E
N
V
D
R
V
T
E
A
L
R
A
A
L
-----------------------------
29
PsiBlast_CBE
68.56
32%
-95
- C1 -
4KYO
9
SPYA_HUMAN
C:
[18-386]
----
K
P
L
S
I
P
N
Q
L
L
L
G
P
G
P
S
N
L
P
P
R
I
M
A
A
G
G
L
Q
M
I
G
S
M
S
K
D
M
Y
Q
I
M
D
E
I
K
E
G
I
Q
Y
V
F
Q
T
-
R
N
P
L
-
T
L
V
I
S
G
S
G
-
H
C
A
L
E
A
A
L
V
N
V
L
E
P
G
D
S
F
L
V
G
A
N
G
I
W
G
Q
R
A
V
D
I
G
E
R
I
G
A
R
V
H
P
M
T
K
D
P
G
G
H
Y
T
L
Q
E
V
E
E
G
L
A
Q
H
K
P
V
L
L
F
L
T
H
G
E
S
S
T
G
V
L
Q
P
L
D
G
F
G
E
L
C
H
R
Y
K
C
L
L
L
V
D
S
V
A
S
L
G
G
T
P
L
Y
M
D
R
Q
G
I
D
I
L
Y
S
G
S
Q
K
A
L
N
A
P
P
G
T
S
L
I
S
F
S
D
K
A
K
K
K
M
Y
S
R
K
-----------------
T
K
P
F
-
S
F
Y
L
D
I
K
W
L
A
N
---
F
W
GCD
D
Q
P
R
M
Y
H
H
T
I
P
V
I
S
L
Y
S
L
R
E
S
L
A
L
I
A
E
Q
G
L
E
N
S
W
R
Q
H
R
E
A
A
A
Y
L
H
G
R
L
Q
A
L
G
L
Q
L
F
V
K
D
P
A
L
R
L
P
T
V
T
T
V
A
V
P
A
G
Y
D
W
R
D
I
V
S
Y
-
V
I
D
H
F
D
I
E
I
M
G
G
L
G
P
S
T
G
K
V
L
R
I
G
L
L
G
C
N
-
A
-
T
-
R
E
N
V
D
R
V
T
E
A
L
R
A
A
L
-----------------------------
39
PsiBlast_CBE
68.43
31%
-96
- C1 -
4I8A
5
SPYA_HUMAN
B:
[18-386]
----
K
P
L
S
I
P
N
Q
L
L
L
G
P
G
P
S
N
L
P
P
R
I
M
A
A
G
G
L
Q
M
I
G
S
M
S
K
D
M
Y
Q
I
M
D
E
I
K
E
G
I
Q
Y
V
F
Q
T
-
R
N
P
L
-
T
L
V
I
S
G
S
G
-
H
C
A
L
E
A
A
L
V
N
V
L
E
P
G
D
S
F
L
V
G
A
N
G
I
W
G
Q
R
A
V
D
I
G
E
R
I
G
A
R
V
H
P
M
T
K
D
P
G
G
H
Y
T
L
Q
E
V
E
E
G
L
A
Q
H
K
P
V
L
L
F
L
T
H
G
E
S
S
T
G
V
L
Q
P
L
D
G
F
G
E
L
C
H
R
Y
K
C
L
L
L
V
D
S
V
A
F
L
G
G
T
P
L
Y
M
D
R
Q
G
I
D
I
L
Y
S
G
S
Q
K
A
L
N
A
P
P
G
T
S
L
I
S
F
S
D
K
A
K
K
K
M
Y
S
R
K
-----------------
T
K
P
F
-
S
F
Y
L
D
I
K
W
L
A
N
---
F
W
GCD
D
Q
P
R
M
Y
H
H
T
I
P
V
I
S
L
Y
S
L
R
E
S
L
A
L
I
A
E
Q
G
L
E
N
S
W
R
Q
H
R
E
A
A
A
Y
L
H
G
R
L
Q
A
L
G
L
Q
L
F
V
K
D
P
A
L
R
L
P
T
V
T
T
V
A
V
P
A
G
Y
D
W
R
D
I
V
S
Y
-
V
I
D
H
F
D
I
E
I
M
G
G
L
G
P
S
T
G
K
V
L
R
I
G
L
L
G
C
N
-
A
-
T
-
R
E
N
V
D
R
V
T
E
A
L
R
A
A
L
-----------------------------
22
PsiBlast_CBE
68.31
34%
-89
- C1 -
2CH2
3
?
D:
[9-380]
-
S
L
R
N
P
L
I
I
P
E
K
I
M
M
G
P
G
P
S
N
C
S
K
R
V
L
T
A
M
T
N
T
V
L
S
N
F
H
A
E
L
F
R
T
M
D
E
V
K
D
G
L
R
Y
I
F
Q
T
-
E
N
R
A
-
T
M
C
V
S
G
S
A
-
H
A
G
M
E
A
M
L
S
N
L
L
E
E
G
D
R
V
L
I
A
V
N
G
I
W
A
E
R
A
V
E
M
S
E
R
Y
G
A
D
V
R
T
I
E
G
P
P
D
R
P
F
S
L
E
T
L
A
R
A
I
E
L
H
Q
P
K
C
L
F
L
T
H
G
D
S
S
S
G
L
L
Q
P
L
E
G
V
G
Q
I
C
H
Q
H
D
C
L
L
I
V
D
A
V
A
S
L
C
G
V
P
F
Y
M
D
K
W
E
I
D
A
V
Y
T
G
A
Q
-
V
L
G
A
P
P
G
I
T
P
I
S
I
S
P
K
A
L
D
V
I
R
N
R
R
T
K
S
K
V
F
------------------
Y
W
D
L
L
L
L
G
N
---
Y
W
GCY
D
E
P
K
R
Y
H
H
T
V
A
S
N
L
I
F
A
L
R
E
A
L
A
Q
I
A
E
E
G
L
E
N
Q
I
K
R
R
I
E
C
A
Q
I
L
Y
E
G
L
G
K
M
G
L
D
I
F
V
K
D
P
R
H
R
L
P
T
V
T
G
I
M
I
P
K
G
V
D
W
W
K
V
S
Q
Y
-
A
M
N
N
F
S
L
E
V
Q
G
G
L
G
P
T
F
G
K
A
W
R
V
G
I
M
G
E
C
-
S
-
T
-
V
Q
K
I
Q
F
Y
L
Y
G
F
K
E
S
L
-----------------------------
30
PsiBlast_CBE
68.19
32%
-93
- C1 -
4KXK
2
SPYA_HUMAN
C:
[18-386]
----
K
P
L
S
I
P
N
Q
L
L
L
G
P
G
P
S
N
L
P
P
R
I
M
A
A
G
G
L
Q
M
I
G
S
M
S
K
D
M
Y
Q
I
M
D
E
I
K
E
G
I
Q
Y
V
F
Q
T
-
R
N
P
L
-
T
L
V
I
S
G
S
G
-
H
C
A
L
E
A
A
L
V
N
V
L
E
P
G
D
S
F
L
V
G
A
N
G
I
W
G
Q
R
A
V
D
I
G
E
R
I
G
A
R
V
H
P
M
T
K
D
P
G
G
H
Y
T
L
Q
E
V
E
E
G
L
A
Q
H
K
P
V
L
L
F
L
T
H
G
E
S
S
T
G
V
L
Q
P
L
D
G
F
G
E
L
C
H
R
Y
K
C
L
L
L
V
D
S
V
A
S
L
G
G
T
P
L
Y
M
D
R
Q
G
I
D
I
L
Y
S
G
S
Q
K
A
L
N
A
P
P
G
T
S
L
I
S
F
S
D
K
A
K
K
K
M
Y
S
R
K
-----------------
T
K
P
F
-
S
F
Y
L
D
I
K
W
L
A
N
---
F
W
GCD
D
Q
P
R
M
Y
H
H
T
I
P
V
I
S
L
Y
S
L
R
E
S
L
A
L
I
A
E
Q
G
L
E
N
S
W
R
Q
H
R
E
A
A
A
Y
L
H
G
R
L
Q
A
L
G
L
Q
L
F
V
K
D
P
A
L
R
L
P
T
V
T
T
V
A
V
P
A
G
Y
D
W
R
D
I
V
S
Y
-
V
I
D
H
F
D
I
E
I
M
G
G
L
G
P
S
T
G
K
V
L
R
I
G
L
L
G
C
N
-
A
-
T
-
R
E
N
V
D
R
V
T
E
A
L
R
A
A
L
-----------------------------
17
PsiBlast_PDB
68.02
31%
-94
- C1 -
3R9A
-
SPYA_HUMAN
A:
[18-386]
----
K
P
L
S
I
P
N
Q
L
L
L
G
P
G
P
S
N
L
P
P
R
I
M
A
A
G
G
L
Q
M
I
G
S
M
S
K
D
M
Y
Q
I
M
D
E
I
K
E
G
I
Q
Y
V
F
Q
T
-
R
N
P
L
-
T
L
V
I
S
G
S
G
-
H
C
A
L
E
A
A
L
V
N
V
L
E
P
G
D
S
F
L
V
G
A
N
G
I
W
G
Q
R
A
V
D
I
G
E
R
I
G
A
R
V
H
P
M
T
K
D
P
G
G
H
Y
T
L
Q
E
V
E
E
G
L
A
Q
H
K
P
V
L
L
F
L
T
H
G
E
S
S
T
G
V
L
Q
P
L
D
G
F
G
E
L
C
H
R
Y
K
C
L
L
L
V
D
S
V
A
S
L
G
G
T
P
L
Y
M
D
R
Q
G
I
D
I
L
Y
S
G
S
Q
K
A
L
N
A
P
P
G
T
S
L
I
S
F
S
D
K
A
K
K
K
M
Y
S
R
K
-----------------
T
K
P
F
-
S
F
Y
L
D
I
K
W
L
A
N
---
F
W
GCD
D
Q
P
R
M
Y
H
H
T
I
P
V
I
S
L
Y
S
L
R
E
S
L
A
L
I
A
E
Q
G
L
E
N
S
W
R
Q
H
R
E
A
A
A
Y
L
H
G
R
L
Q
A
L
G
L
Q
L
F
V
K
D
P
A
L
R
L
P
T
V
T
T
V
A
V
P
A
G
Y
D
W
R
D
I
V
S
Y
-
V
I
D
H
F
D
I
E
I
M
G
G
L
G
P
S
T
G
K
V
L
R
I
G
L
L
G
C
N
-
A
-
T
-
R
E
N
V
D
R
V
T
E
A
L
R
A
A
L
-----------------------------
14
PsiBlast_PDB
67.99
32%
-94
- C1 -
1H0C
8
SPYA_HUMAN
A:
[16-384]
----
K
P
L
S
I
P
N
Q
L
L
L
G
P
G
P
S
N
L
P
P
R
I
M
A
A
G
G
L
Q
M
I
G
S
M
S
K
D
M
Y
Q
I
M
D
E
I
K
E
G
I
Q
Y
V
F
Q
T
-
R
N
P
L
-
T
L
V
I
S
G
S
G
-
H
C
A
L
E
A
A
L
V
N
V
L
E
P
G
D
S
F
L
V
G
A
N
G
I
W
G
Q
R
A
V
D
I
G
E
R
I
G
--
V
H
P
M
T
K
D
P
G
G
H
Y
T
L
Q
E
V
E
E
G
L
A
Q
H
K
P
V
L
L
F
L
T
H
G
E
S
S
T
G
V
L
Q
P
L
D
G
F
G
E
L
C
H
R
Y
K
C
L
L
L
V
D
S
V
A
S
L
G
G
T
P
L
Y
M
D
R
Q
G
I
D
I
L
Y
S
G
S
Q
K
A
L
N
A
P
P
G
T
S
L
I
S
F
S
D
K
A
K
K
K
M
Y
S
R
K
-----------------
T
K
P
F
-
S
F
Y
L
D
I
K
W
L
A
N
---
F
W
GCD
D
Q
P
R
M
Y
H
H
T
I
P
V
I
S
L
Y
S
L
R
E
S
L
A
L
I
A
E
Q
G
L
E
N
S
W
R
Q
H
R
E
A
A
A
Y
L
H
G
R
L
Q
A
L
G
L
Q
L
F
V
K
D
P
A
L
R
L
P
T
V
T
T
V
A
V
P
A
G
Y
D
W
R
D
I
V
S
Y
-
V
I
D
H
F
D
I
E
I
M
G
G
L
G
P
S
T
G
K
V
L
R
I
G
L
L
G
C
N
-
A
-
T
-
R
E
N
V
D
R
V
T
E
A
L
R
A
A
L
-----------------------------
18
PsiBlast_PDB
67.93
31%
-95
- C1 -
4I8A
4
SPYA_HUMAN
A:
[18-386]
----
K
P
L
S
I
P
N
Q
L
L
L
G
P
G
P
S
N
L
P
P
R
I
M
A
A
G
G
L
Q
M
I
G
S
M
S
K
D
M
Y
Q
I
M
D
E
I
K
E
G
I
Q
Y
V
F
Q
T
-
R
N
P
L
-
T
L
V
I
S
G
S
G
-
H
C
A
L
E
A
A
L
V
N
V
L
E
P
G
D
S
F
L
V
G
A
N
G
I
W
G
Q
R
A
V
D
I
G
E
R
I
G
A
R
V
H
P
M
T
K
D
P
G
G
H
Y
T
L
Q
E
V
E
E
G
L
A
Q
H
K
P
V
L
L
F
L
T
H
G
E
S
S
T
G
V
L
Q
P
L
D
G
F
G
E
L
C
H
R
Y
K
C
L
L
L
V
D
S
V
A
F
L
G
G
T
P
L
Y
M
D
R
Q
G
I
D
I
L
Y
S
G
S
Q
K
A
L
N
A
P
P
G
T
S
L
I
S
F
S
D
K
A
K
K
K
M
Y
S
R
K
-----------------
T
K
P
F
-
S
F
Y
L
D
I
K
W
L
A
N
---
F
W
GCD
D
Q
P
R
M
Y
H
H
T
I
P
V
I
S
L
Y
S
L
R
E
S
L
A
L
I
A
E
Q
G
L
E
N
S
W
R
Q
H
R
E
A
A
A
Y
L
H
G
R
L
Q
A
L
G
L
Q
L
F
V
K
D
P
A
L
R
L
P
T
V
T
T
V
A
V
P
A
G
Y
D
W
R
D
I
V
S
Y
-
V
I
D
H
F
D
I
E
I
M
G
G
L
G
P
S
T
G
K
V
L
R
I
G
L
L
G
C
N
-
A
-
T
-
R
E
N
V
D
R
V
T
E
A
L
R
A
A
L
-----------------------------
38
PsiBlast_CBE
67.84
31%
-96
- C1 -
4I8A
4
SPYA_HUMAN
C:
[18-386]
----
K
P
L
S
I
P
N
Q
L
L
L
G
P
G
P
S
N
L
P
P
R
I
M
A
A
G
G
L
Q
M
I
G
S
M
S
K
D
M
Y
Q
I
M
D
E
I
K
E
G
I
Q
Y
V
F
Q
T
-
R
N
P
L
-
T
L
V
I
S
G
S
G
-
H
C
A
L
E
A
A
L
V
N
V
L
E
P
G
D
S
F
L
V
G
A
N
G
I
W
G
Q
R
A
V
D
I
G
E
R
I
G
A
R
V
H
P
M
T
K
D
P
G
G
H
Y
T
L
Q
E
V
E
E
G
L
A
Q
H
K
P
V
L
L
F
L
T
H
G
E
S
S
T
G
V
L
Q
P
L
D
G
F
G
E
L
C
H
R
Y
K
C
L
L
L
V
D
S
V
A
F
L
G
G
T
P
L
Y
M
D
R
Q
G
I
D
I
L
Y
S
G
S
Q
K
A
L
N
A
P
P
G
T
S
L
I
S
F
S
D
K
A
K
K
K
M
Y
S
R
K
-----------------
T
K
P
F
-
S
F
Y
L
D
I
K
W
L
A
N
---
F
W
GCD
D
Q
P
R
M
Y
H
H
T
I
P
V
I
S
L
Y
S
L
R
E
S
L
A
L
I
A
E
Q
G
L
E
N
S
W
R
Q
H
R
E
A
A
A
Y
L
H
G
R
L
Q
A
L
G
L
Q
L
F
V
K
D
P
A
L
R
L
P
T
V
T
T
V
A
V
P
A
G
Y
D
W
R
D
I
V
S
Y
-
V
I
D
H
F
D
I
E
I
M
G
G
L
G
P
S
T
G
K
V
L
R
I
G
L
L
G
C
N
-
A
-
T
-
R
E
N
V
D
R
V
T
E
A
L
R
A
A
L
-----------------------------
28
PsiBlast_CBE
67.81
31%
-93
- C1 -
2YOB
9
SPYA_HUMAN
B:
[16-385]
----
K
P
L
S
I
P
N
Q
L
L
L
G
P
G
P
S
N
L
P
P
R
I
M
A
A
G
G
L
Q
M
I
G
S
M
S
K
D
M
Y
Q
I
M
D
E
I
K
E
G
I
Q
Y
V
F
Q
T
-
R
N
P
L
-
T
L
V
I
S
G
S
G
-
H
C
A
L
E
A
A
L
V
N
V
L
E
P
G
D
S
F
L
V
G
A
N
G
I
W
G
Q
R
A
V
D
I
G
E
R
I
G
A
R
V
H
P
M
T
K
D
P
G
G
H
Y
T
L
Q
E
V
E
E
G
L
A
Q
H
K
P
V
L
L
F
L
T
H
G
E
S
S
T
G
V
L
Q
P
L
D
G
F
G
E
L
C
H
R
Y
K
C
L
L
L
V
D
S
V
A
S
L
G
G
T
P
L
Y
M
D
R
Q
G
I
D
I
L
Y
S
G
S
Q
K
A
L
N
A
P
P
G
T
S
L
I
S
F
S
D
K
A
K
K
K
M
Y
S
R
K
-----------------
T
K
P
F
-
S
F
Y
L
D
I
K
W
L
A
N
---
F
W
GCD
D
Q
P
R
M
Y
H
H
T
I
P
V
I
S
L
Y
S
L
R
E
S
L
A
L
I
A
E
Q
G
L
E
N
S
W
R
Q
H
R
E
A
A
A
Y
L
H
G
R
L
Q
A
L
G
L
Q
L
F
V
K
D
P
A
L
R
L
P
T
V
T
T
V
A
V
P
A
G
Y
D
W
R
D
I
V
S
Y
-
V
M
D
H
F
D
I
E
I
M
G
G
L
G
P
S
T
G
K
V
L
R
I
G
L
L
G
C
N
-
A
-
T
-
R
E
N
V
D
R
V
T
E
A
L
R
A
A
L
V
----------------------------
36
PsiBlast_CBE
67.79
31%
-92
- C1 -
3R9A
1
SPYA_HUMAN
C:
[18-386]
----
K
P
L
S
I
P
N
Q
L
L
L
G
P
G
P
S
N
L
P
P
R
I
M
A
A
G
G
L
Q
M
I
G
S
M
S
K
D
M
Y
Q
I
M
D
E
I
K
E
G
I
Q
Y
V
F
Q
T
-
R
N
P
L
-
T
L
V
I
S
G
S
G
-
H
C
A
L
E
A
A
L
V
N
V
L
E
P
G
D
S
F
L
V
G
A
N
G
I
W
G
Q
R
A
V
D
I
G
E
R
I
G
A
R
V
H
P
M
T
K
D
P
G
G
H
Y
T
L
Q
E
V
E
E
G
L
A
Q
H
K
P
V
L
L
F
L
T
H
G
E
S
S
T
G
V
L
Q
P
L
D
G
F
G
E
L
C
H
R
Y
K
C
L
L
L
V
D
S
V
A
S
L
G
G
T
P
L
Y
M
D
R
Q
G
I
D
I
L
Y
S
G
S
Q
K
A
L
N
A
P
P
G
T
S
L
I
S
F
S
D
K
A
K
K
K
M
Y
S
R
K
-----------------
T
K
P
F
-
S
F
Y
L
D
I
K
W
L
A
N
---
F
W
GCD
D
Q
P
R
M
Y
H
H
T
I
P
V
I
S
L
Y
S
L
R
E
S
L
A
L
I
A
E
Q
G
L
E
N
S
W
R
Q
H
R
E
A
A
A
Y
L
H
G
R
L
Q
A
L
G
L
Q
L
F
V
K
D
P
A
L
R
L
P
T
V
T
T
V
A
V
P
A
G
Y
D
W
R
D
I
V
S
Y
-
V
I
D
H
F
D
I
E
I
M
G
G
L
G
P
S
T
G
K
V
L
R
I
G
L
L
G
C
N
-
A
-
T
-
R
E
N
V
D
R
V
T
E
A
L
R
A
A
L
-----------------------------
4
PsiBlast_PDB
67.72
34%
-88
- C1 -
2CH1
4
?
A:
[9-380]
-
S
L
R
N
P
L
I
I
P
E
K
I
M
M
G
P
G
P
S
N
C
S
K
R
V
L
T
A
M
T
N
T
V
L
S
N
F
H
A
E
L
F
R
T
M
D
E
V
K
D
G
L
R
Y
I
F
Q
T
-
E
N
R
A
-
T
M
C
V
S
G
S
A
-
H
A
G
M
E
A
M
L
S
N
L
L
E
E
G
D
R
V
L
I
A
V
N
G
I
W
A
E
R
A
V
E
M
S
E
R
Y
G
A
D
V
R
T
I
E
G
P
P
D
R
P
F
S
L
E
T
L
A
R
A
I
E
L
H
Q
P
K
C
L
F
L
T
H
G
D
S
S
S
G
L
L
Q
P
L
E
G
V
G
Q
I
C
H
Q
H
D
C
L
L
I
V
D
A
V
A
S
L
C
G
V
P
F
Y
M
D
K
W
E
I
D
A
V
Y
T
G
A
Q
-
V
L
G
A
P
P
G
I
T
P
I
S
I
S
P
K
A
L
D
V
I
R
N
R
R
T
K
S
K
V
F
------------------
Y
W
D
L
L
L
L
G
N
---
Y
W
GCY
D
E
P
K
R
Y
H
H
T
V
A
S
N
L
I
F
A
L
R
E
A
L
A
Q
I
A
E
E
G
L
E
N
Q
I
K
R
R
I
E
C
A
Q
I
L
Y
E
G
L
G
K
M
G
L
D
I
F
V
K
D
P
R
H
R
L
P
T
V
T
G
I
M
I
P
K
G
V
D
W
W
K
V
S
Q
Y
-
A
M
N
N
F
S
L
E
V
Q
G
G
L
G
P
T
F
G
K
A
W
R
V
G
I
M
G
E
C
-
S
-
T
-
V
Q
K
I
Q
F
Y
L
Y
G
F
K
E
S
L
-----------------------------
13
PsiBlast_PDB
67.57
32%
-93
- C1 -
4KXK
3
SPYA_HUMAN
A:
[18-386]
----
K
P
L
S
I
P
N
Q
L
L
L
G
P
G
P
S
N
L
P
P
R
I
M
A
A
G
G
L
Q
M
I
G
S
M
S
K
D
M
Y
Q
I
M
D
E
I
K
E
G
I
Q
Y
V
F
Q
T
-
R
N
P
L
-
T
L
V
I
S
G
S
G
-
H
C
A
L
E
A
A
L
V
N
V
L
E
P
G
D
S
F
L
V
G
A
N
G
I
W
G
Q
R
A
V
D
I
G
E
R
I
G
A
R
V
H
P
M
T
K
D
P
G
G
H
Y
T
L
Q
E
V
E
E
G
L
A
Q
H
K
P
V
L
L
F
L
T
H
G
E
S
S
T
G
V
L
Q
P
L
D
G
F
G
E
L
C
H
R
Y
K
C
L
L
L
V
D
S
V
A
S
L
G
G
T
P
L
Y
M
D
R
Q
G
I
D
I
L
Y
S
G
S
Q
K
A
L
N
A
P
P
G
T
S
L
I
S
F
S
D
K
A
K
K
K
M
Y
S
R
K
-----------------
T
K
P
F
-
S
F
Y
L
D
I
K
W
L
A
N
---
F
W
GCD
D
Q
P
R
M
Y
H
H
T
I
P
V
I
S
L
Y
S
L
R
E
S
L
A
L
I
A
E
Q
G
L
E
N
S
W
R
Q
H
R
E
A
A
A
Y
L
H
G
R
L
Q
A
L
G
L
Q
L
F
V
K
D
P
A
L
R
L
P
T
V
T
T
V
A
V
P
A
G
Y
D
W
R
D
I
V
S
Y
-
V
I
D
H
F
D
I
E
I
M
G
G
L
G
P
S
T
G
K
V
L
R
I
G
L
L
G
C
N
-
A
-
T
-
R
E
N
V
D
R
V
T
E
A
L
R
A
A
L
-----------------------------
24
PsiBlast_CBE
67.50
34%
-90
- C1 -
2CH2
3
?
B:
[9-380]
-
S
L
R
N
P
L
I
I
P
E
K
I
M
M
G
P
G
P
S
N
C
S
K
R
V
L
T
A
M
T
N
T
V
L
S
N
F
H
A
E
L
F
R
T
M
D
E
V
K
D
G
L
R
Y
I
F
Q
T
-
E
N
R
A
-
T
M
C
V
S
G
S
A
-
H
A
G
M
E
A
M
L
S
N
L
L
E
E
G
D
R
V
L
I
A
V
N
G
I
W
A
E
R
A
V
E
M
S
E
R
Y
G
A
D
V
R
T
I
E
G
P
P
D
R
P
F
S
L
E
T
L
A
R
A
I
E
L
H
Q
P
K
C
L
F
L
T
H
G
D
S
S
S
G
L
L
Q
P
L
E
G
V
G
Q
I
C
H
Q
H
D
C
L
L
I
V
D
A
V
A
S
L
C
G
V
P
F
Y
M
D
K
W
E
I
D
A
V
Y
T
G
A
Q
-
V
L
G
A
P
P
G
I
T
P
I
S
I
S
P
K
A
L
D
V
I
R
N
R
R
T
K
S
K
V
F
------------------
Y
W
D
L
L
L
L
G
N
---
Y
W
GCY
D
E
P
K
R
Y
H
H
T
V
A
S
N
L
I
F
A
L
R
E
A
L
A
Q
I
A
E
E
G
L
E
N
Q
I
K
R
R
I
E
C
A
Q
I
L
Y
E
G
L
G
K
M
G
L
D
I
F
V
K
D
P
R
H
R
L
P
T
V
T
G
I
M
I
P
K
G
V
D
W
W
K
V
S
Q
Y
-
A
M
N
N
F
S
L
E
V
Q
G
G
L
G
P
T
F
G
K
A
W
R
V
G
I
M
G
E
C
-
S
-
T
-
V
Q
K
I
Q
F
Y
L
Y
G
F
K
E
S
L
-----------------------------
11
PsiBlast_PDB
67.32
32%
-93
- C1 -
4CBR
2
SPYA_HUMAN
A:
[16-384]
----
K
P
L
S
I
P
N
Q
L
L
L
G
P
G
P
S
N
L
P
P
R
I
M
A
A
G
G
L
Q
M
I
G
H
M
S
K
E
M
Y
Q
I
M
D
E
I
K
E
G
I
Q
Y
V
F
Q
T
-
R
N
P
L
-
T
L
V
I
S
G
S
G
-
H
C
A
L
E
A
A
L
V
N
V
L
E
P
G
D
S
F
L
V
G
A
N
G
I
W
G
Q
R
A
V
D
I
G
E
R
I
G
A
R
V
H
P
M
T
K
D
P
G
G
H
Y
T
L
Q
E
V
E
E
G
L
A
Q
H
K
P
V
L
L
F
L
T
H
G
E
S
S
T
G
V
L
Q
P
L
D
G
F
G
E
L
C
H
R
Y
K
C
L
L
L
V
D
S
V
A
S
L
G
G
T
P
L
Y
M
D
R
Q
G
I
D
I
L
Y
S
G
S
Q
K
A
L
N
A
P
P
G
T
S
L
I
S
F
S
D
K
A
K
K
K
M
Y
S
R
K
-----------------
T
K
P
F
-
S
F
Y
L
D
I
K
W
L
A
N
---
F
W
GCD
D
Q
P
R
M
Y
H
H
T
I
P
V
I
S
L
Y
S
L
R
E
S
L
A
L
I
A
E
Q
G
L
E
N
S
W
R
Q
H
R
E
A
A
A
Y
L
H
G
R
L
Q
A
L
G
L
Q
L
F
V
K
D
P
A
L
R
L
P
T
V
T
T
V
A
V
P
A
G
Y
D
W
R
D
I
V
S
Y
-
V
M
D
H
F
D
I
E
I
M
G
G
L
G
P
S
T
G
K
V
L
R
I
G
L
L
G
C
N
-
A
-
T
-
R
E
N
V
D
R
V
T
E
A
L
R
A
A
L
-----------------------------
19
PsiBlast_PDB
66.79
31%
-92
- C1 -
1J04
8
SPYA_HUMAN
A:
[16-384]
----
K
P
L
S
I
P
N
Q
L
L
L
G
P
G
P
S
N
L
P
P
R
I
M
A
A
G
G
L
Q
M
I
G
S
M
S
K
D
M
Y
Q
I
M
D
E
I
K
E
G
I
Q
Y
V
F
Q
T
-
R
N
P
L
-
T
L
V
I
S
G
S
G
-
H
C
A
L
E
A
A
L
V
N
V
L
E
P
G
D
S
F
L
V
G
A
N
G
I
W
G
Q
R
A
V
D
I
G
E
R
I
G
A
R
V
H
P
M
T
K
D
P
G
G
H
Y
T
L
Q
E
V
E
E
G
L
A
Q
H
K
P
V
L
L
F
L
T
H
G
E
S
S
T
G
V
L
Q
P
L
D
G
F
R
E
L
C
H
R
Y
K
C
L
L
L
V
D
S
V
A
S
L
G
G
T
P
L
Y
M
D
R
Q
G
I
D
I
L
Y
S
G
S
Q
K
A
L
N
A
P
P
G
T
S
L
I
S
F
S
D
K
A
K
K
K
M
Y
S
R
K
-----------------
T
K
P
F
-
S
F
Y
L
D
I
K
W
L
A
N
---
F
W
GCD
D
Q
P
R
M
Y
H
H
T
I
P
V
I
S
L
Y
S
L
R
E
S
L
A
L
I
A
E
Q
G
L
E
N
S
W
R
Q
H
R
E
A
A
A
Y
L
H
G
R
L
Q
A
L
G
L
Q
L
F
V
K
D
P
A
L
R
L
P
T
V
T
T
V
A
V
P
A
G
Y
D
W
R
D
I
V
S
Y
-
V
I
D
H
F
D
I
E
I
M
G
G
L
G
P
S
T
G
K
V
L
R
I
G
L
L
G
C
N
-
A
-
T
-
R
E
N
V
D
R
V
T
E
A
L
R
A
A
L
-----------------------------
51
HHSearch
62.45
32%
-77
- C1 -
2HUF
2
?
A:
[13-385]
----
E
P
L
V
T
P
N
K
L
L
M
G
P
G
P
S
N
A
P
Q
R
V
L
D
A
M
S
R
P
I
L
G
H
L
H
P
E
T
L
K
I
M
D
D
I
K
E
G
V
R
Y
L
F
Q
T
-
N
N
I
A
-
T
F
C
L
S
A
S
G
-
H
G
G
M
E
A
T
L
C
N
L
L
E
D
G
D
V
I
L
I
G
H
T
G
H
W
G
D
R
S
A
D
M
A
T
R
Y
G
A
D
V
R
V
V
K
S
K
V
G
Q
S
L
S
L
D
E
I
R
D
A
L
L
I
H
K
P
S
V
L
F
L
T
Q
G
D
S
S
T
G
V
L
Q
G
L
E
G
V
G
A
L
C
H
Q
H
N
C
L
L
I
V
D
T
V
A
S
L
G
G
A
P
M
F
M
D
R
W
E
I
D
A
M
Y
T
G
S
Q
K
V
L
G
A
P
P
G
I
T
P
V
S
F
S
H
R
A
V
E
R
Y
K
R
R
---
N
T
K
V
K
---------------
V
Y
Y
W
D
M
S
L
V
G
D
Y
WG
C
F
---
G
R
P
R
I
Y
H
H
T
I
S
S
T
L
L
Y
G
L
R
E
A
I
A
M
A
C
E
E
G
L
P
A
L
I
A
R
H
E
D
C
A
K
R
L
Y
R
G
L
Q
D
A
G
F
E
L
Y
-
A
D
P
K
D
R
L
S
T
V
T
T
I
K
V
P
Q
G
V
D
W
L
K
A
A
Q
Y
-
A
M
K
T
Y
L
V
E
I
S
G
G
L
G
P
T
A
G
Q
V
F
R
I
G
L
M
G
Q
N
A
T
-
T
-
E
R
-
V
D
R
V
L
Q
V
F
Q
E
A
V
A
A
V
K
P
------------------------
7
PsiBlast_PDB
62.35
31%
-78
- C1 -
2HUF
2
?
A:
[12-373]
---
R
E
P
L
V
T
P
N
K
L
L
M
G
P
G
P
S
N
A
P
Q
R
V
L
D
A
M
S
R
P
I
L
G
H
L
H
P
E
T
L
K
I
M
D
D
I
K
E
G
V
R
Y
L
F
Q
T
-
N
N
I
A
-
T
F
C
L
S
A
S
G
-
H
G
G
M
E
A
T
L
C
N
L
L
E
D
G
D
V
I
L
I
G
H
T
G
H
W
G
D
R
S
A
D
M
A
T
R
Y
G
A
D
V
R
V
V
K
S
K
V
G
Q
S
L
S
L
D
E
I
R
D
A
L
L
I
H
K
P
S
V
L
F
L
T
Q
G
D
S
S
T
G
V
L
Q
G
L
E
G
V
G
A
L
C
H
Q
H
N
C
L
L
I
V
D
T
V
A
S
L
G
G
A
P
M
F
M
D
R
W
E
I
D
A
M
Y
T
G
S
Q
K
V
L
G
A
P
P
G
I
T
P
V
S
F
S
H
R
A
V
E
R
Y
K
R
R
------------------
N
T
K
V
K
V
Y
Y
W
D
M
S
L
V
G
D
---
Y
W
GCF
G
R
P
R
I
Y
H
H
T
I
S
S
T
L
L
Y
G
L
R
E
A
I
A
M
A
C
E
E
G
L
P
A
L
I
A
R
H
E
D
C
A
K
R
L
Y
R
G
L
Q
D
A
G
F
E
L
Y
-
A
D
P
K
D
R
L
S
T
V
T
T
I
K
V
P
Q
G
V
D
W
L
K
A
A
Q
Y
-
A
M
K
T
Y
L
V
E
I
S
G
G
L
G
P
T
A
G
Q
V
F
R
I
G
L
M
G
Q
N
-
A
-
T
-
T
E
R
V
D
R
V
L
------------------------------------
8
PsiBlast_PDB
62.14
31%
-77
- C1 -
2HUI
2
?
A:
[12-373]
---
R
E
P
L
V
T
P
N
K
L
L
M
G
P
G
P
S
N
A
P
Q
R
V
L
D
A
M
S
R
P
I
L
G
H
L
H
P
E
T
L
K
I
M
D
D
I
K
E
G
V
R
Y
L
F
Q
T
-
N
N
I
A
-
T
F
C
L
S
A
S
G
-
H
G
G
M
E
A
T
L
C
N
L
L
E
D
G
D
V
I
L
I
G
H
T
G
H
W
G
D
R
S
A
D
M
A
T
R
Y
G
A
D
V
R
V
V
K
S
K
V
G
Q
S
L
S
L
D
E
I
R
D
A
L
L
I
H
K
P
S
V
L
F
L
T
Q
G
D
S
S
T
G
V
L
Q
G
L
E
G
V
G
A
L
C
H
Q
H
N
C
L
L
I
V
D
T
V
A
S
L
G
G
A
P
M
F
M
D
R
W
E
I
D
A
M
Y
T
G
S
Q
K
V
L
G
A
P
P
G
I
T
P
V
S
F
S
H
R
A
V
E
R
Y
K
R
R
------------------
N
T
K
V
K
V
Y
Y
W
D
M
S
L
V
G
D
---
Y
W
GCF
G
R
P
R
I
Y
H
H
T
I
S
S
T
L
L
Y
G
L
R
E
A
I
A
M
A
C
E
E
G
L
P
A
L
I
A
R
H
E
D
C
A
K
R
L
Y
R
G
L
Q
D
A
G
F
E
L
Y
-
A
D
P
K
D
R
L
S
T
V
T
T
I
K
V
P
Q
G
V
D
W
L
K
A
A
Q
Y
-
A
M
K
T
Y
L
V
E
I
S
G
G
L
G
P
T
A
G
Q
V
F
R
I
G
L
M
G
Q
N
-
A
-
T
-
T
E
R
V
D
R
V
L
------------------------------------
9
PsiBlast_PDB
61.88
31%
-77
- C1 -
2HUU
2
?
A:
[12-373]
---
R
E
P
L
V
T
P
N
K
L
L
M
G
P
G
P
S
N
A
P
Q
R
V
L
D
A
M
S
R
P
I
L
G
H
L
H
P
E
T
L
K
I
M
D
D
I
K
E
G
V
R
Y
L
F
Q
T
-
N
N
I
A
-
T
F
C
L
S
A
S
G
-
H
G
G
M
E
A
T
L
C
N
L
L
E
D
G
D
V
I
L
I
G
H
T
G
H
W
G
D
R
S
A
D
M
A
T
R
Y
G
A
D
V
R
V
V
K
S
K
V
G
Q
S
L
S
L
D
E
I
R
D
A
L
L
I
H
K
P
S
V
L
F
L
T
Q
G
D
S
S
T
G
V
L
Q
G
L
E
G
V
G
A
L
C
H
Q
H
N
C
L
L
I
V
D
T
V
A
S
L
G
G
A
P
M
F
M
D
R
W
E
I
D
A
M
Y
T
G
S
Q
K
V
L
G
A
P
P
G
I
T
P
V
S
F
S
H
R
A
V
E
R
Y
K
R
R
------------------
N
T
K
V
K
V
Y
Y
W
D
M
S
L
V
G
D
---
Y
W
GCF
G
R
P
R
I
Y
H
H
T
I
S
S
T
L
L
Y
G
L
R
E
A
I
A
M
A
C
E
E
G
L
P
A
L
I
A
R
H
E
D
C
A
K
R
L
Y
R
G
L
Q
D
A
G
F
E
L
Y
-
A
D
P
K
D
R
L
S
T
V
T
T
I
K
V
P
Q
G
V
D
W
L
K
A
A
Q
Y
-
A
M
K
T
Y
L
V
E
I
S
G
G
L
G
P
T
A
G
Q
V
F
R
I
G
L
M
G
Q
N
-
A
-
T
-
T
E
R
V
D
R
V
L
------------------------------------
35
PsiBlast_CBE
61.86
31%
-78
- C1 -
2HUF
2
?
B:
[12-373]
---
R
E
P
L
V
T
P
N
K
L
L
M
G
P
G
P
S
N
A
P
Q
R
V
L
D
A
M
S
R
P
I
L
G
H
L
H
P
E
T
L
K
I
M
D
D
I
K
E
G
V
R
Y
L
F
Q
T
-
N
N
I
A
-
T
F
C
L
S
A
S
G
-
H
G
G
M
E
A
T
L
C
N
L
L
E
D
G
D
V
I
L
I
G
H
T
G
H
W
G
D
R
S
A
D
M
A
T
R
Y
G
A
D
V
R
V
V
K
S
K
V
G
Q
S
L
S
L
D
E
I
R
D
A
L
L
I
H
K
P
S
V
L
F
L
T
Q
G
D
S
S
T
G
V
L
Q
G
L
E
G
V
G
A
L
C
H
Q
H
N
C
L
L
I
V
D
T
V
A
S
L
G
G
A
P
M
F
M
D
R
W
E
I
D
A
M
Y
T
G
S
Q
K
V
L
G
A
P
P
G
I
T
P
V
S
F
S
H
R
A
V
E
R
Y
K
R
R
------------------
N
T
K
V
K
V
Y
Y
W
D
M
S
L
V
G
D
---
Y
W
GCF
G
R
P
R
I
Y
H
H
T
I
S
S
T
L
L
Y
G
L
R
E
A
I
A
M
A
C
E
E
G
L
P
A
L
I
A
R
H
E
D
C
A
K
R
L
Y
R
G
L
Q
D
A
G
F
E
L
Y
-
A
D
P
K
D
R
L
S
T
V
T
T
I
K
V
P
Q
G
V
D
W
L
K
A
A
Q
Y
-
A
M
K
T
Y
L
V
E
I
S
G
G
L
G
P
T
A
G
Q
V
F
R
I
G
L
M
G
Q
N
-
A
-
T
-
T
E
R
V
D
R
V
L
------------------------------------
33
PsiBlast_CBE
61.73
31%
-77
- C1 -
2HUU
2
?
B:
[12-373]
---
R
E
P
L
V
T
P
N
K
L
L
M
G
P
G
P
S
N
A
P
Q
R
V
L
D
A
M
S
R
P
I
L
G
H
L
H
P
E
T
L
K
I
M
D
D
I
K
E
G
V
R
Y
L
F
Q
T
-
N
N
I
A
-
T
F
C
L
S
A
S
G
-
H
G
G
M
E
A
T
L
C
N
L
L
E
D
G
D
V
I
L
I
G
H
T
G
H
W
G
D
R
S
A
D
M
A
T
R
Y
G
A
D
V
R
V
V
K
S
K
V
G
Q
S
L
S
L
D
E
I
R
D
A
L
L
I
H
K
P
S
V
L
F
L
T
Q
G
D
S
S
T
G
V
L
Q
G
L
E
G
V
G
A
L
C
H
Q
H
N
C
L
L
I
V
D
T
V
A
S
L
G
G
A
P
M
F
M
D
R
W
E
I
D
A
M
Y
T
G
S
Q
K
V
L
G
A
P
P
G
I
T
P
V
S
F
S
H
R
A
V
E
R
Y
K
R
R
------------------
N
T
K
V
K
V
Y
Y
W
D
M
S
L
V
G
D
---
Y
W
GCF
G
R
P
R
I
Y
H
H
T
I
S
S
T
L
L
Y
G
L
R
E
A
I
A
M
A
C
E
E
G
L
P
A
L
I
A
R
H
E
D
C
A
K
R
L
Y
R
G
L
Q
D
A
G
F
E
L
Y
-
A
D
P
K
D
R
L
S
T
V
T
T
I
K
V
P
Q
G
V
D
W
L
K
A
A
Q
Y
-
A
M
K
T
Y
L
V
E
I
S
G
G
L
G
P
T
A
G
Q
V
F
R
I
G
L
M
G
Q
N
-
A
-
T
-
T
E
R
V
D
R
V
L
------------------------------------
34
PsiBlast_CBE
61.58
31%
-78
- C1 -
2HUI
2
?
B:
[12-373]
---
R
E
P
L
V
T
P
N
K
L
L
M
G
P
G
P
S
N
A
P
Q
R
V
L
D
A
M
S
R
P
I
L
G
H
L
H
P
E
T
L
K
I
M
D
D
I
K
E
G
V
R
Y
L
F
Q
T
-
N
N
I
A
-
T
F
C
L
S
A
S
G
-
H
G
G
M
E
A
T
L
C
N
L
L
E
D
G
D
V
I
L
I
G
H
T
G
H
W
G
D
R
S
A
D
M
A
T
R
Y
G
A
D
V
R
V
V
K
S
K
V
G
Q
S
L
S
L
D
E
I
R
D
A
L
L
I
H
K
P
S
V
L
F
L
T
Q
G
D
S
S
T
G
V
L
Q
G
L
E
G
V
G
A
L
C
H
Q
H
N
C
L
L
I
V
D
T
V
A
S
L
G
G
A
P
M
F
M
D
R
W
E
I
D
A
M
Y
T
G
S
Q
K
V
L
G
A
P
P
G
I
T
P
V
S
F
S
H
R
A
V
E
R
Y
K
R
R
------------------
N
T
K
V
K
V
Y
Y
W
D
M
S
L
V
G
D
---
Y
W
GCF
G
R
P
R
I
Y
H
H
T
I
S
S
T
L
L
Y
G
L
R
E
A
I
A
M
A
C
E
E
G
L
P
A
L
I
A
R
H
E
D
C
A
K
R
L
Y
R
G
L
Q
D
A
G
F
E
L
Y
-
A
D
P
K
D
R
L
S
T
V
T
T
I
K
V
P
Q
G
V
D
W
L
K
A
A
Q
Y
-
A
M
K
T
Y
L
V
E
I
S
G
G
L
G
P
T
A
G
Q
V
F
R
I
G
L
M
G
Q
N
-
A
-
T
-
T
E
R
V
D
R
V
L
------------------------------------
42
PsiBlast_CBE
57.06
32%
-34
- C1 -
2YRI
2
?
B:
[3-350]
-------------
L
L
T
P
G
P
T
P
I
P
E
R
V
Q
K
A
L
L
R
P
M
R
G
H
L
D
P
E
V
L
R
V
N
R
A
I
Q
E
R
L
A
A
L
F
D
P
G
E
G
A
L
-
V
A
A
L
A
G
S
G
-
S
L
G
M
E
A
G
L
A
N
L
--
D
R
G
P
V
L
V
L
V
N
G
A
F
S
Q
R
V
A
E
M
A
A
L
H
G
L
D
P
E
V
L
D
F
P
P
G
E
P
V
D
P
E
A
V
A
R
A
L
K
R
R
R
Y
R
M
V
A
L
V
H
G
E
T
S
T
G
V
L
N
P
A
E
A
I
G
A
L
A
K
E
A
G
A
L
F
F
L
D
A
V
T
T
L
G
M
L
P
F
S
M
R
A
M
G
V
D
Y
A
F
T
G
S
Q
K
C
L
S
A
P
P
G
L
A
P
I
A
-------------------
A
S
L
E
A
R
K
A
F
T
G
K
R
---
G
W
Y
L
D
L
A
R
V
A
E
---
H
W
----
E
R
G
G
Y
H
H
T
T
P
V
L
L
H
Y
A
L
L
E
A
L
D
L
V
L
E
E
G
V
A
A
R
E
R
R
A
R
E
V
Y
A
W
V
L
E
E
L
K
A
R
G
F
R
P
Y
--
P
K
A
S
P
L
P
T
V
L
V
V
R
P
P
E
G
V
D
A
D
R
L
V
R
A
-
L
Y
A
E
-
G
V
A
V
A
G
G
I
G
P
T
R
G
Q
V
L
R
L
G
L
M
G
E
G
-
A
-
R
-
R
E
A
Y
Q
A
F
L
K
A
L
D
R
A
L
-----------------------------
20
PsiBlast_PDB
57.00
32%
-34
- C1 -
2YRI
2
?
A:
[3-350]
-------------
L
L
T
P
G
P
T
P
I
P
E
R
V
Q
K
A
L
L
R
P
M
R
G
H
L
D
P
E
V
L
R
V
N
R
A
I
Q
E
R
L
A
A
L
F
D
P
G
E
G
A
L
-
V
A
A
L
A
G
S
G
-
S
L
G
M
E
A
G
L
A
N
L
--
D
R
G
P
V
L
V
L
V
N
G
A
F
S
Q
R
V
A
E
M
A
A
L
H
G
L
D
P
E
V
L
D
F
P
P
G
E
P
V
D
P
E
A
V
A
R
A
L
K
R
R
R
Y
R
M
V
A
L
V
H
G
E
T
S
T
G
V
L
N
P
A
E
A
I
G
A
L
A
K
E
A
G
A
L
F
F
L
D
A
V
T
T
L
G
M
L
P
F
S
M
R
A
M
G
V
D
Y
A
F
T
G
S
Q
K
C
L
S
A
P
P
G
L
A
P
I
A
-------------------
A
S
L
E
A
R
K
A
F
T
G
K
R
---
G
W
Y
L
D
L
A
R
V
A
E
---
H
W
----
E
R
G
G
Y
H
H
T
T
P
V
L
L
H
Y
A
L
L
E
A
L
D
L
V
L
E
E
G
V
A
A
R
E
R
R
A
R
E
V
Y
A
W
V
L
E
E
L
K
A
R
G
F
R
P
Y
--
P
K
A
S
P
L
P
T
V
L
V
V
R
P
P
E
G
V
D
A
D
R
L
V
R
A
-
L
Y
A
E
-
G
V
A
V
A
G
G
I
G
P
T
R
G
Q
V
L
R
L
G
L
M
G
E
G
-
A
-
R
-
R
E
A
Y
Q
A
F
L
K
A
L
D
R
A
L
-----------------------------
40
PsiBlast_CBE
56.45
32%
-33
- C1 -
2YRR
2
?
B:
[3-350]
-------------
L
L
T
P
G
P
T
P
I
P
E
R
V
Q
K
A
L
L
R
P
M
R
G
H
L
D
P
E
V
L
R
V
N
R
A
I
Q
E
R
L
A
A
L
F
D
P
G
E
G
A
L
-
V
A
A
L
A
G
S
G
-
S
L
G
M
E
A
G
L
A
N
L
--
D
R
G
P
V
L
V
L
V
N
G
A
F
S
Q
R
V
A
E
M
A
A
L
H
G
L
D
P
E
V
L
D
F
P
P
G
E
P
V
D
P
E
A
V
A
R
A
L
K
R
R
R
Y
R
M
V
A
L
V
H
G
E
T
S
T
G
V
L
N
P
A
E
A
I
G
A
L
A
K
E
A
G
A
L
F
F
L
D
A
V
T
T
L
G
M
L
P
F
S
M
R
A
M
G
V
D
Y
A
F
T
G
S
Q
K
C
L
S
A
P
P
G
L
A
P
I
A
-------------------
A
S
L
E
A
R
K
A
F
T
G
K
R
---
G
W
Y
L
D
L
A
R
V
A
E
---
H
W
----
E
R
G
G
Y
H
H
T
T
P
V
L
L
H
Y
A
L
L
E
A
L
D
L
V
L
E
E
G
V
A
A
R
E
R
R
A
R
E
V
Y
A
W
V
L
E
E
L
K
A
R
G
F
R
P
Y
--
P
K
A
S
P
L
P
T
V
L
V
V
R
P
P
E
G
V
D
A
D
R
L
V
R
A
-
L
Y
A
E
-
G
V
A
V
A
G
G
I
G
P
T
R
G
Q
V
L
R
L
G
L
M
G
E
G
-
A
-
R
-
R
E
A
Y
Q
A
F
L
K
A
L
D
R
A
L
-----------------------------
41
PsiBlast_CBE
56.22
32%
-33
- C1 -
2YRR
2
?
A:
[3-350]
-------------
L
L
T
P
G
P
T
P
I
P
E
R
V
Q
K
A
L
L
R
P
M
R
G
H
L
D
P
E
V
L
R
V
N
R
A
I
Q
E
R
L
A
A
L
F
D
P
G
E
G
A
L
-
V
A
A
L
A
G
S
G
-
S
L
G
M
E
A
G
L
A
N
L
--
D
R
G
P
V
L
V
L
V
N
G
A
F
S
Q
R
V
A
E
M
A
A
L
H
G
L
D
P
E
V
L
D
F
P
P
G
E
P
V
D
P
E
A
V
A
R
A
L
K
R
R
R
Y
R
M
V
A
L
V
H
G
E
T
S
T
G
V
L
N
P
A
E
A
I
G
A
L
A
K
E
A
G
A
L
F
F
L
D
A
V
T
T
L
G
M
L
P
F
S
M
R
A
M
G
V
D
Y
A
F
T
G
S
Q
K
C
L
S
A
P
P
G
L
A
P
I
A
-------------------
A
S
L
E
A
R
K
A
F
T
G
K
R
---
G
W
Y
L
D
L
A
R
V
A
E
---
H
W
----
E
R
G
G
Y
H
H
T
T
P
V
L
L
H
Y
A
L
L
E
A
L
D
L
V
L
E
E
G
V
A
A
R
E
R
R
A
R
E
V
Y
A
W
V
L
E
E
L
K
A
R
G
F
R
P
Y
--
P
K
A
S
P
L
P
T
V
L
V
V
R
P
P
E
G
V
D
A
D
R
L
V
R
A
-
L
Y
A
E
-
G
V
A
V
A
G
G
I
G
P
T
R
G
Q
V
L
R
L
G
L
M
G
E
G
-
A
-
R
-
R
E
A
Y
Q
A
F
L
K
A
L
D
R
A
L
-----------------------------
54
HHSearch
53.27
32%
-30
- C1 -
2YRR
2
?
A:
[2-352]
------------
L
L
L
T
P
G
P
T
P
I
P
E
R
V
Q
K
A
L
L
R
P
M
R
G
H
L
D
P
E
V
L
R
V
N
R
A
I
Q
E
R
L
A
A
L
F
D
P
-
G
E
G
A
L
V
A
A
L
A
G
S
G
-
S
L
G
M
E
A
G
L
A
N
L
-
D
R
G
P
V
L
V
L
V
N
G
A
F
S
Q
R
-
V
A
E
M
A
A
L
H
G
L
D
P
E
V
L
D
F
P
P
G
E
P
V
D
P
E
A
V
A
R
A
L
K
R
R
R
Y
R
M
V
A
L
V
H
G
E
T
S
T
G
V
L
N
P
A
E
A
I
G
A
L
A
K
E
A
G
A
L
F
F
L
D
A
V
T
T
L
G
M
L
P
F
S
M
R
A
M
G
V
D
Y
A
F
T
G
S
Q
K
C
L
S
A
P
P
G
L
A
P
I
A
A
S
L
E
A
R
K
A
F
T
G
K
----
R
G
W
Y
L
------------------
D
L
A
R
V
A
E
---
H
W
---
E
-
R
G
G
Y
H
H
T
T
P
V
L
L
H
Y
A
L
L
E
A
L
D
L
V
L
E
E
G
V
A
A
R
E
R
R
A
R
E
V
Y
A
W
V
L
E
E
L
K
A
R
G
F
R
P
Y
-
P
K
A
-
S
P
L
P
T
V
L
V
V
R
P
P
E
G
V
D
A
D
R
L
V
R
A
-
L
Y
-
A
E
G
V
A
V
A
G
G
I
G
P
T
R
G
Q
V
L
R
L
G
L
M
G
E
G
-
A
R
R
-
E
A
-
Y
Q
A
F
L
K
A
L
D
R
A
L
A
L
---------------------------