@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu32610: (2016-07-24 )
MSQATAKVNREVQAFLQDLKGKTIDHVFFVACGGSSAIMYPSKYVFDRESKSINSDLYSANEFIQRNPVQLGEKSLVILCSHSGNTPETVKAAAFARGKGALTIAMTFKPESPLAQEAQYVAQYDWGDEALAINTNYGVLYQIVFGTLQVLENNTKFEQAIEGLDQLQAVYEKALKQEADNAKQFAKAHEKESIIYTMASGANYGVAYSYSICILMEMQWIHSHAIHAGEYFHGPFEIIDESVPFIILLGLDETRPLEERALTFSKKYGKKLTVLDAASYDFTAIDDSVKGYLAPLVLNRVLRSYADELAEERNHPLSHRRYMWKVEY
Atome Classification :
(20 SA)
.........-10..-......20-.-.......30........40....--....50..--......60......-.-.70........80........90.......-.100.-.......110.......120.....--..-----130----.-----.--...--...140..--.....150--...-.--..---..----160.......170.......180--.....-.-..190.......200......-.210.-.-----.....220.......230.......240.......250.......260-.......-270.......280------.------.--.-....290...-....300.......310----.......320......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MS
Q
A
T
A
K
V
N
-
R
E
V
Q
-
A
F
L
Q
D
LKG-K-
T
I
D
H
V
F
F
V
A
CGGS
S
A
I
M
YPS
K
Y
V
--FDRESKSI--NS
D
L
Y
S
A
N
E
F
I
QRN-P-VQLGE
K
S
L
V
I
L
CSHSGNT
P
E
T
V
K
A
A
AFARG-K
G
A
-
L
-
T
I
A
M
T
FKPESP
L
A
Q
E
A
Q
Y
V
AQYDWG--D
E
-----
A
L
-----
A
-----
I
--NTN--
Y
G
V
L
Y
Q
I
V
--
F
G
T
L
Q
V
L---ENN-
T
--
K
F
---
E
Q
----
A
I
E
G
L
D
Q
L
Q
A
V
Y
E
K
A
L
K
QEAD
N
---
A
K
Q
F
A
-
K
-
A
HEKE
S
I
I
Y
T
MASGANY
G
V
A
Y
-
S
Y
S
I
C
-
I
-----
L
M
E
M
Q
W
I
H
SHAIHAGEYFH
G
P
F
E
I
IDESV
P
F
I
I
L
L
GLDETR
P
L
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R
A
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-
T
F
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KYG-
K
K
L
T
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DAASYDF------T------A--I-D
D
S
V
K
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L
A
P
-
L
V
L
N
R
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L
R
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Y
A
D
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L
A
E
E----RNHPLSH
R
R
Y
M
W
K
VEY
1
PsiBlast_PDB
94.66
98%
-123
- C3 -
3EUA
-
FRLB_BACSU
A:
[5-329]
---
A
T
A
K
V
N
-
R
E
V
Q
-
A
F
L
Q
D
L
K
G
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K
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A
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A
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--
F
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E
S
K
S
I
--
N
S
D
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N
-
P
-
V
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A
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D
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--
D
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A
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-----
A
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T
N
--
Y
G
V
L
Y
Q
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--
F
G
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L
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L
---
E
N
N
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----
A
I
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Q
L
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A
L
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Q
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N
---
A
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F
A
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K
-
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K
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A
Y
-
S
Y
S
I
C
-
I
-----
L
M
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M
Q
W
I
H
S
H
A
I
H
A
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F
H
G
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L
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T
F
S
K
K
Y
G
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K
K
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L
D
A
A
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Y
D
F
------
T
------
A
--
I
-
D
D
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K
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-
L
V
L
N
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L
A
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----
R
N
H
P
L
S
H
R
R
Y
M
W
K
V
E
Y
40
HHSearch
84.11
98%
-17
- C3 -
3EUA
-
FRLB_BACSU
A:
[5-329]
---
A
T
-
A
K
V
N
R
E
V
Q
-
A
F
L
Q
D
L
K
G
-
K
-
T
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H
V
F
F
V
A
C
G
G
S
S
A
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M
Y
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Y
V
--
F
D
R
E
--
S
K
S
I
N
S
D
L
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S
A
N
E
F
I
Q
R
N
-
P
-
V
Q
L
G
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K
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L
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I
L
C
S
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N
T
P
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A
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G
-
K
G
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L
-
T
I
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V
A
Q
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D
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A
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-----
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--
N
T
N
--
Y
G
V
L
Y
Q
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V
--
F
G
T
L
Q
V
L
---
E
N
N
-
T
--
K
F
---
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Q
----
A
I
E
G
L
D
Q
L
Q
A
V
Y
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K
A
L
K
Q
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A
D
N
---
A
K
Q
F
A
-
K
-
A
H
E
K
E
S
I
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Y
T
M
A
S
G
A
N
Y
G
V
A
Y
-
S
-
Y
S
I
C
I
-----
L
M
E
M
Q
W
I
H
S
H
A
I
H
A
G
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Y
F
H
G
P
F
E
I
I
D
E
S
V
P
F
I
I
L
L
G
L
D
E
T
R
P
L
E
E
R
A
L
-
T
F
S
K
K
Y
G
-
K
K
L
T
V
L
D
A
A
S
Y
D
F
------
T
------
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--
I
-
D
D
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K
G
Y
L
A
P
-
L
V
L
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L
A
E
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----
R
N
H
P
L
S
H
R
R
Y
M
W
K
V
E
Y
42
HHSearch
73.55
27%
-125
- C3 -
2A3N
1
?
A:
[40-355]
----------
Q
K
A
E
-
Q
V
A
D
E
I
Y
Q
-
A
-
G
F
S
S
L
F
F
A
S
V
G
G
S
L
A
P
M
M
A
I
N
E
F
--
A
K
E
L
-
T
T
L
--
P
V
Y
V
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Q
A
A
E
L
I
H
K
G
-
N
-
K
R
L
N
K
D
S
V
V
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L
S
K
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G
D
T
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A
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W
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K
A
-
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G
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-
R
-
V
V
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A
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P
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R
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K
--
N
G
------
V
-----
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-----
Y
----
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--
Y
M
L
L
Y
W
L
F
--
F
R
V
L
S
R
N
---
N
E
F
-
A
--
S
Y
---
D
R
----
F
A
S
Q
L
E
I
L
P
A
N
L
L
K
A
K
Q
K
F
D
P
Q
---
A
D
A
I
A
-
S
-
R
Y
H
N
S
D
Y
M
M
W
V
G
G
A
E
M
W
G
E
V
Y
-
L
F
S
M
C
-
I
-----
L
E
E
M
Q
W
K
R
T
R
P
V
S
S
A
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F
F
H
G
A
L
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L
L
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D
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P
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I
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G
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G
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A
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V
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R
F
A
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A
L
------
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--
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P
C
V
V
S
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L
L
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R
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A
A
H
F
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K
Y
----
T
G
H
S
L
D
I
R
R
Y
Y
R
Q
F
D
Y
2
PsiBlast_PDB
63.70
37%
-37
- C3 -
3FKJ
1
?
A:
[18-347]
--
Q
G
M
S
V
A
H
-
E
N
A
R
-
R
I
I
S
D
I
L
G
-
K
Q
N
I
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R
V
W
F
V
G
C
G
G
S
L
T
G
F
W
P
G
K
Y
F
--
L
D
C
E
A
S
K
L
--
A
V
G
Y
I
T
S
N
E
F
V
H
A
T
-
P
-
K
A
L
G
K
N
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V
V
I
L
A
S
Q
Q
G
N
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A
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T
V
A
A
A
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A
R
E
-
K
G
A
-
A
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T
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G
L
V
Y
Q
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P
L
C
E
Y
S
D
Y
I
I
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Y
Q
W
A
--
R
Y
-----
P
E
-----
T
-----
V
--
D
P
A
--
Q
Q
K
A
A
Y
S
L
--
W
L
A
L
E
I
L
A
Q
T
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G
Y
-
A
--
Q
Y
---
D
E
----
L
V
S
A
F
G
R
F
S
D
V
V
H
G
A
Q
R
Q
V
Q
E
D
---
A
Q
R
F
A
-
A
-
E
W
K
D
E
K
V
V
Y
M
M
G
S
G
P
S
F
G
A
A
H
-
Q
E
S
I
C
-
I
-----
L
L
E
M
Q
W
I
N
S
A
S
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H
S
G
E
Y
F
H
G
P
F
E
I
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E
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G
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L
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S
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R
T
R
P
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D
R
A
I
-
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F
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R
Y
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G
K
L
Q
L
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D
A
D
K
L
G
I
------
Q
------
D
--
L
-
S
T
D
V
G
E
Y
F
C
G
-
L
L
H
N
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V
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V
Y
N
L
A
L
A
T
A
----
R
N
H
P
L
T
T
R
R
Y
M
W
K
V
E
Y
41
HHSearch
62.31
39%
-29
* C3 *
3FKJ
1
?
A:
[18-347]
---
Q
G
M
S
V
A
H
E
N
A
R
-
R
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D
I
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N
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AQ
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Y
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L
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Q
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D
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A
Q
R
F
A
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A
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Y
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L
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D
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L
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I
------
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------
D
--
L
-
S
T
D
V
G
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Y
F
C
G
-
L
L
H
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V
L
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A
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A
----
R
N
H
P
L
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T
R
R
Y
M
W
K
V
E
Y
47
HHSearch
56.17
19%
-59
- C3 -
2ZJ3
1
GFPT1_HUMAN
A:
[48-372]
----------
G
G
L
K
-
D
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E
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---
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R
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-
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--
P
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M
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---
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E
----
I
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N
A
L
-
Q
Q
V
V
A
R
Q
-
G
R
P
V
V
I
C
D
K
E
D
T
E
T
I
K
N
TK
R
------
T
--
I
K
V
P
H
S
V
D
C
L
Q
G
-
I
L
S
V
I
P
L
Q
L
L
A
F
H
L
A
V
L
----
R
G
Y
D
V
D
F
P
R
N
L
A
K
S
V
-
3
PsiBlast_PDB
56.17
29%
-7
- C3 -
2A3N
1
?
A:
[57-355]
------------------------------
L
F
F
A
S
V
G
G
S
L
A
---
P
M
M
A
I
N
E
F
A
K
E
L
T
T
L
--
P
V
Y
V
E
Q
A
A
E
L
I
H
K
G
-
N
-
K
R
L
N
K
D
S
V
V
I
T
L
S
K
S
G
D
T
K
E
S
V
A
I
A
E
W
C
K
A
-
Q
G
I
-
R
-
V
V
A
I
T
K
N
A
D
S
P
L
A
Q
A
A
T
W
H
I
P
M
R
H
K
--
N
-------------
G
-----
V
--
E
Y
E
--
Y
M
L
L
Y
W
L
F
--
F
---
R
V
L
---
S
R
N
-
N
--
E
F
AS
Y
D
R
----
F
A
S
Q
L
E
I
L
P
A
N
L
L
K
A
K
Q
K
F
D
P
Q
---
A
D
A
I
A
-
S
-
R
Y
H
N
S
D
Y
M
M
W
V
G
G
A
E
M
W
G
E
V
Y
-
L
F
S
M
C
-
I
-----
L
E
E
M
Q
W
K
R
T
R
P
V
S
S
A
E
F
F
H
G
A
L
E
L
L
E
K
D
V
P
L
I
L
V
K
G
E
G
K
C
R
A
L
D
E
R
V
E
-
R
F
A
S
K
I
T
-
D
N
L
V
V
I
D
P
K
A
Y
A
L
------
D
------
G
--
I
-
D
D
E
F
R
W
I
M
A
P
-
C
V
V
S
T
L
L
---
V
D
R
L
A
A
H
F
E
K
Y
T
G
H
S
L
D
I
R
R
Y
Y
R
Q
F
D
Y
45
HHSearch
55.44
19%
-72
- C3 -
2POC
4
GFA1_CANAL
A:
[40-355]
------------
L
K
-
S
W
L
S
T
I
---
R
-
R
C
R
R
I
I
M
I
A
C
G
T
S
Y
H
S
C
L
A
T
R
S
I
--
F
E
E
L
-
T
E
I
--
P
V
S
V
E
L
A
S
D
F
L
D
R
R
-
S
--
P
V
F
R
D
D
T
C
V
F
V
S
Q
S
G
E
T
A
D
S
I
L
A
L
Q
Y
C
L
E
-
R
G
A
-
L
-
T
V
G
I
V
N
S
V
G
S
S
M
S
R
Q
T
H
C
G
V
H
I
N
A
G
--
P
E
-----
I
G
VAS
T
K
A
-----
Y
--
T
S
Q
--
Y
I
A
L
V
M
F
A
--
L
S
L
S
N
D
S
---
I
S
R
K
G
--
R
H
---
E
E
----
I
I
K
G
L
Q
K
I
P
E
Q
I
K
Q
V
L
K
L
E
N
-
K
---
I
K
D
L
C
N
S
-
S
L
N
D
Q
K
S
L
L
L
L
G
R
G
Y
Q
F
A
T
A
L
-
E
-
G
A
L
-
K
-----
I
K
E
I
S
Y
M
H
S
E
G
V
L
A
G
E
L
-----------
L
P
I
I
A
F
A
T
R
D
S
L
F
P
K
V
M
S
A
I
-
E
Q
V
T
A
R
D
-
G
R
P
I
V
I
C
N
E
G
D
A
I
ISV
H
--
T
------
T
--
L
E
V
P
E
T
V
D
C
L
Q
G
-
L
L
N
V
I
P
L
Q
L
I
S
Y
W
L
A
V
N
----
R
G
I
D
V
D
----------
50
HHSearch
54.54
24%
-22
- C3 -
4AMV
1
GLMS_ECOLI
A:
[280-606]
----------
S
E
L
G
P
N
A
D
E
L
L
---
S
-
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
--
F
E
S
L
-
A
G
I
--
P
C
D
V
E
I
A
S
E
F
R
Y
-
R
-
K
-
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
-
L
G
Y
L
G
-
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
--
T
E
-----
I
G
VAST
K
A
-----
F
--
T
T
Q
--
L
T
V
L
L
M
L
V
--
A
K
L
S
K
L
K
---
G
L
D
A
S
--
I
E
---
H
D
----
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
-
D
K
R
---
I
E
A
L
A
-
E
-
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
-
E
-
G
A
L
-
K
-----
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
-
E
E
V
R
A
R
G
-
G
Q
L
Y
V
F
A
D
Q
D
A
G
F
VSSDNM
H
------
I
--
I
E
M
P
H
V
E
E
V
I
A
P
-
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
----
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
-
51
HHSearch
54.00
24%
-25
- C3 -
1MOQ
8
GLMS_ECOLI
A:
[39-365]
----------
S
E
L
G
P
N
A
D
E
L
L
---
S
-
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
--
F
E
S
L
-
A
G
I
--
P
C
D
V
E
I
A
S
E
F
R
Y
R
--
K
-
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
-
L
G
Y
L
G
-
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
--
T
E
-----
I
G
VAST
K
A
-----
F
--
T
T
Q
--
L
T
V
L
L
M
L
V
--
A
K
L
S
R
L
K
---
G
L
D
A
S
--
I
E
---
H
D
----
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
-
D
K
R
---
I
E
A
L
A
-
E
-
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
-
E
-
G
A
L
-
K
-----
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
-
E
E
V
R
A
R
G
-
G
Q
L
Y
V
F
A
D
Q
D
A
G
F
------
V
S
S
DN
M
H
I
--
I
E
M
P
H
V
E
E
V
I
A
P
-
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
----
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
-
6
PsiBlast_PDB
51.22
21%
-89
- C3 -
2ZJ3
1
A:
[62-315]
-----------------------------
R
L
I
L
I
A
C
G
T
S
Y
H
A
G
V
A
T
R
Q
V
--
L
E
-
E
L
T
E
L
--
P
V
M
V
E
L
A
S
D
F
L
D
R
N
T
P
-
V
--
F
R
D
D
V
C
F
F
L
S
Q
S
G
E
T
A
D
T
L
M
G
L
R
Y
C
K
E
-
R
G
A
-
L
-
T
V
G
I
T
N
T
V
G
S
S
I
S
R
E
T
D
C
G
V
H
I
N
A
G
--
P
E
-----
I
G
-----
V
-----
A
--
S
T
K
A
Y
T
S
Q
F
V
S
L
V
--
M
F
A
L
M
M
C
---
D
D
R
-
I
--
S
M
---
Q
E
R
R
K
E
I
M
L
G
L
K
R
L
P
D
L
I
K
E
V
L
S
M
D
D
E
I
---
Q
K
L
A
T
-
E
-
L
Y
H
Q
K
S
V
L
I
-------
M
G
R
G
Y
-
H
Y
A
T
C
-
L
E
G
A
L
K
I
K
E
I
T
Y
M
H
S
E
G
I
L
A
G
E
L
K
H
G
P
L
A
L
V
D
K
L
M
P
V
I
M
I
I
M
R
D
H
T
Y
A
K
C
Q
N
A
L
Q
Q
V
V
A
R
Q
G
-
R
P
V
V
I
C
D
------------------------------------------------------------------------
4
PsiBlast_PDB
50.40
21%
-89
- C3 -
2V4M
2
GFPT1_HUMAN
A:
[63-316]
-----------------------------
R
L
I
L
I
A
C
G
T
S
Y
H
A
G
V
A
T
R
Q
V
--
L
E
-
E
L
T
E
L
--
P
V
M
V
E
L
A
S
D
F
L
D
R
N
T
P
-
V
--
F
R
D
D
V
C
F
F
L
S
Q
S
G
E
T
A
D
T
L
M
G
L
R
Y
C
K
E
-
R
G
A
-
L
-
T
V
G
I
T
N
T
V
G
S
S
I
S
R
E
T
D
C
G
V
H
I
N
A
G
--
P
E
-----
I
G
-----
V
-----
A
--
S
T
K
A
Y
T
S
Q
F
V
S
L
V
--
M
F
A
L
M
M
C
---
D
D
R
-
I
--
S
M
---
Q
E
R
R
K
E
I
M
L
G
L
K
R
L
P
D
L
I
K
E
V
L
S
M
D
D
E
I
---
Q
K
L
A
T
-
E
-
L
Y
H
Q
K
S
V
L
I
-------
M
G
R
G
Y
-
H
Y
A
T
C
-
L
E
G
A
L
K
I
K
E
I
T
Y
M
H
S
E
G
I
L
A
G
E
L
K
H
G
P
L
A
L
V
D
K
L
M
P
V
I
M
I
I
M
R
D
H
T
Y
A
K
C
Q
N
A
L
Q
Q
V
V
A
R
Q
G
-
R
P
V
V
I
C
D
------------------------------------------------------------------------
7
PsiBlast_PDB
50.39
21%
-87
- C3 -
2ZJ4
1
A:
[62-315]
-----------------------------
R
L
I
L
I
A
C
G
T
S
Y
H
A
G
V
A
T
R
Q
V
--
L
E
-
E
L
T
E
L
--
P
V
M
V
E
L
A
S
D
F
L
D
R
N
T
P
-
V
--
F
R
D
D
V
C
F
F
L
S
Q
S
G
E
T
A
D
T
L
M
G
L
R
Y
C
K
E
-
R
G
A
-
L
-
T
V
G
I
T
N
T
V
G
S
S
I
S
R
E
T
D
C
G
V
H
I
N
A
G
--
P
E
-----
I
G
-----
V
-----
A
--
S
T
K
A
Y
T
S
Q
F
V
S
L
V
--
M
F
A
L
M
M
C
---
D
D
R
-
I
--
S
M
---
Q
E
R
R
K
E
I
M
L
G
L
K
R
L
P
D
L
I
K
E
V
L
S
M
D
D
E
I
---
Q
K
L
A
T
-
E
-
L
Y
H
Q
K
S
V
L
I
-------
M
G
R
G
Y
-
H
Y
A
T
C
-
L
E
G
A
L
K
I
K
E
I
T
Y
M
H
S
E
G
I
L
A
G
E
L
K
H
G
P
L
A
L
V
D
K
L
M
P
V
I
M
I
I
M
R
D
H
T
Y
A
K
C
Q
N
A
L
Q
Q
V
V
A
R
Q
G
-
R
P
V
V
I
C
D
------------------------------------------------------------------------
54
HHSearch
49.86
18%
-46
- C3 -
2E5F
4
?
A:
[19-323]
----------
K
V
F
N
-
K
V
K
D
K
I
---
S
-
L
P
N
R
I
L
Y
L
G
C
G
S
S
H
F
L
S
K
L
L
A
M
V
--
T
N
M
H
--
G
G
--
L
G
I
A
L
P
C
S
E
F
L
Y
S
K
-
E
T
Y
P
I
G
E
V
E
L
A
V
G
I
S
R
S
G
E
T
T
E
I
L
L
A
L
E
K
I
----
N
V
-
K
-
K
L
G
I
T
T
-
R
E
S
S
L
T
R
M
C
D
Y
S
L
V
V
P
A
I
--
E
E
------
S
-----
V
V----
M
--
T
H
S
--
F
T
S
F
Y
F
A
Y
--
L
Q
L
L
R
Y
S
---
Y
G
L
-
P
--
P
------------
L
N
A
G
E
I
S
K
A
T
E
K
S
L
E
-
Y
E
R
Y
---
I
R
E
I
V
-
E
-
S
F
-
D
F
Q
N
I
I
F
L
G
S
G
L
L
Y
P
V
A
L
-
E
-
A
S
L
-
K
-----
M
K
E
M
S
I
F
W
S
E
A
Y
P
T
F
E
V
R
H
G
F
K
A
I
A
D
E
K
T
L
V
V
L
M
V
E
E
P
--
F
E
W
H
E
K
L
V
-
K
E
F
K
N
Q
G
-
A
K
V
L
V
I
S
N
S
P
Q
D
L
GQD---
Y
------
S
--
I
E
L
P
R
L
S
K
D
A
N
P
-
I
P
Y
L
P
I
V
Q
L
L
S
Y
Y
K
A
V
S
----
R
G
L
N
P
D
N
P
R
F
L
D
K
V
V
-
53
HHSearch
48.79
14%
-40
- C3 -
2AML
2
?
A:
[39-358]
------------
A
E
-
K
L
E
S
L
V
K
--
N
-
G
A
K
E
W
L
I
L
A
T
G
S
S
L
N
A
A
Q
S
A
K
Y
Y
--
I
E
N
L
-
A
D
V
--
R
I
T
I
E
E
P
F
N
H
L
Y
Y
--
E
-
K
L
S
S
H
L
D
L
V
I
G
I
S
Q
S
G
Q
S
T
S
T
I
S
A
L
E
R
V
K
K
E
A
S
V
-
P
-
V
V
A
L
T
S
D
V
T
S
E
I
A
E
F
A
D
I
T
L
D
I
G
S
G
--
K
E
-----
R
V
GYVT
K
G
-----
F
--
T
A
T
--
V
L
T
L
M
L
T
G
--
L
H
F
A
Y
K
T
---
V
Q
I
-
D
E
T
R
F
---
N
N
----
E
I
S
A
F
S
R
A
I
D
A
I
P
A
T
I
A
E
T
E
A
F
---
Y
E
R
W
Q
-
E
-
E
F
A
T
A
P
K
F
T
A
I
G
Y
G
P
T
V
G
T
C
K
-
E
-
F
E
T
-
K
-----
F
S
E
T
V
R
V
P
S
Q
G
L
D
L
E
A
F
M
H
G
P
Y
L
E
V
N
P
Q
H
R
I
F
F
L
E
T
A
S
A
V
T
E
R
L
-
V
L
L
-
R
D
Y
E
S
K
Y
T
P
F
T
Y
T
V
K
F
G
K
G
E
D
D-----
R
TL----
V
--
I
-
P
T
D
L
D
E
Y
Q
A
P
-
F
L
M
I
L
P
F
Q
I
L
A
H
H
I
A
E
L
----
K
G
N
K
L
T
E
R
I
Y
T
D
----
48
HHSearch
48.28
18%
-38
- C3 -
4S1W
2
?
A:
[41-342]
----------------
I
I
N
D
V
---
K
-
E
A
D
R
I
Y
V
I
A
A
G
T
S
Y
H
A
G
L
V
G
K
E
F
--
L
E
K
W
-
A
G
V
--
P
T
E
V
H
V
A
S
E
F
V
Y
N
M
---
P
L
L
S
E
K
P
L
F
V
Y
I
S
Q
S
G
E
T
A
D
S
R
A
V
L
V
E
T
N
K
-
L
G
H
-
K
-
S
L
T
I
T
N
V
A
G
S
T
L
S
R
E
A
D
H
T
L
L
L
H
A
G
--
P
E
-----
I
A
-----
V
AST
K
A
Y
--
T
A
Q
--
I
A
V
L
S
I
L
S
--
Q
I
V
A
K
E
H
-----
E
----
A
D
---
I
D
----
L
L
R
E
L
A
K
V
T
T
A
I
E
A
I
V
D
D
A
-
P
I
---
M
E
Q
I
A
-
T
D
F
L
E
T
T
R
N
A
F
F
I
G
R
T
I
D
Y
N
V
S
L
-
E
-
G
A
L
-
K
-----
L
K
E
I
S
Y
I
Q
A
E
G
F
A
G
G
E
L
K
H
G
T
I
A
L
I
E
D
G
T
P
V
V
A
L
A
T
Q
E
N
V
N
L
S
I
R
G
N
V
-
K
E
V
V
A
R
G
-
A
H
P
C
I
I
S
M
E
G
L
E
K
EG----
D
------
T
--
Y
V
I
P
H
V
H
E
L
L
T
P
-
L
V
S
V
V
A
L
Q
L
I
S
Y
Y
A
A
L
H
----
R
D
--------------
49
HHSearch
47.47
18%
-72
- C3 -
3FJ1
3
?
A:
[41-332]
------------------------
R
-
D
P
S
F
V
A
T
V
A
R
G
S
S
D
H
V
C
T
Y
L
S
Y
A
--
A
E
L
L
-
L
G
L
--
P
V
A
S
L
G
P
S
V
A
S
V
Y
D
-
A
-
R
L
R
L
D
R
A
L
C
L
A
V
S
Q
S
G
K
S
P
D
I
V
A
M
T
R
N
A
G
R
-
D
G
A
-
L
-
C
V
A
L
T
N
D
A
A
S
P
L
A
G
V
S
A
H
T
I
D
I
H
A
G
--
P
E
-----
L
S
-----
V
-----
A
A-
T
K
T
--
F
V
T
S
A
V
A
G
--
L
M
L
L
A
D
W
---
A
E
D
---------
D
G
----
L
R
A
A
L
G
N
L
P
E
T
L
A
A
A
S
R
I
D
--
W
---
P
-
E
M
R
-
V
-
A
I
G
A
R
P
S
L
F
T
L
G
R
G
T
S
L
A
V
S
N
-
E
-
A
A
L
-
K
-----
F
K
E
T
C
Q
L
H
A
E
S
Y
S
S
A
E
V
L
H
G
P
V
S
I
V
E
E
G
F
P
V
L
G
F
A
A
G
D
A
A
E
A
P
L
A
E
I
A
-
D
Q
I
A
A
K
G
-
A
T
V
F
A
T
T
G
R
V
T
R
A
------
R
------
V
L
E
H
-
V
R
S
G
H
A
L
T
D
P
-
L
S
L
I
V
S
F
Y
S
M
V
E
A
F
A
S
E
----
R
G
I
D
P
D
----------
8
PsiBlast_PDB
47.07
27%
-91
- C3 -
4AMV
1
GLMS_ECOLI
A:
[293-520]
---------------------------
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
--
F
E
S
L
A
-
G
I
--
P
C
D
V
E
I
A
S
E
F
R
Y
R
K
-
S
-
A
-
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
-
L
G
Y
-
L
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
--
T
E
IGVAS
T
K
-----
A
-----
F
--
T
T
Q
--
L
T
V
L
L
M
L
V
A
K
L
S
K
L
K
G
L
---
D
A
S
-
I
--
E
H
---
D
-----
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
L
A
E
D
F
S
-
D
-
K
H
H
A
----
L
F
L
G
R
G
D
Q
Y
P
I
A
L
-
E
G
A
L
K
-------
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
46.70
27%
-84
- C3 -
1MOS
4
GLMS_ECOLI
A:
[52-279]
---------------------------
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
--
F
E
S
L
A
-
G
I
--
P
C
D
V
E
I
A
S
E
F
R
Y
R
K
-
S
-
A
-
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
-
L
G
Y
-
L
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
--
T
E
IGVAS
T
K
-----
A
-----
F
--
T
T
Q
--
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
---
D
A
S
-
I
--
E
H
---
D
-----
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
L
A
E
D
F
S
-
D
-
K
H
H
A
----
L
F
L
G
R
G
D
Q
Y
P
I
A
L
-
E
G
A
L
K
-------
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
46.15
27%
-87
- C3 -
3OOJ
6
GLMS_ECOLI
A:
[292-519]
---------------------------
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
--
F
E
S
L
A
-
G
I
--
P
C
D
V
E
I
A
S
E
F
R
Y
R
K
-
S
-
A
-
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
-
L
G
Y
-
L
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
--
T
E
IGVAS
T
K
-----
A
-----
F
--
T
T
Q
--
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
---
D
A
S
-
I
--
E
H
---
D
-----
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
L
A
E
D
F
S
-
D
-
K
H
H
A
----
L
F
L
G
R
G
D
Q
Y
P
I
A
L
-
E
G
A
L
K
-------
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
------------------------------------------------------------------------------------------------------