@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu32690: (2016-07-24 )
MNITDIREQFPILHQQVNGHDLVYLDSAATSQKPRAVIETLDKYYNQYNSNVHRGVHTLGTRATDGYEGAREKVRKFINAKSMAEIIFTKGTTTSLNMVALSYARANLKPGDEVVITYMEHHANIIPWQQAVKATGATLKYIPLQEDGTISLEDVRETVTSNTKIVAVSHVSNVLGTVNPIKEMAKIAHDNGAVIVVDGAQSTPHMKIDVQDLDCDFFALSSHKMCGPTGVGVLYGKKALLENMEPAEFGGEMIDFVGLYESTWKELPWKFEAGTPIIAGAIGLGAAIDFLEEIGLDEISRHEHKLAAYALERFRQLDGVTVYGPEERAGLVTFNLDDVHPHDVATVLDAEGIAVRAGHHCAQPLMKWLDVTATARASFYLYNTEEEIDKLVEALQKTKEYFTNVF
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260........270.......280.......290.......300.......310.......320..-..-----...330.......340.......350-........360.......370.......380.......390.......400....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
N
I
T
D
I
R
E
QF
P
I
L
H
QQVNGH
D
L
V
Y
LDSAATSQK
P
R
A
V
I
E
T
L
D
K
Y
Y
N
Q
YNS
N
V
H
R
G
V
H
T
LGTRATDGYE
G
A
R
E
K
V
R
K
F
I
N
A
K
S
M
A
E
I
I
FTKGTTT
S
L
N
M
V
A
L
S
Y
A
RANLKPG
D
E
V
V
I
T
Y
M
E
HHANII
P
W
Q
Q
A
V
K
ATG
A
T
L
K
Y
I
PLQED
G
T
I
S
L
E
D
V
R
E
T
VTSN
T
K
I
V
A
V
S
H
V
S
N
V
LG
T
V
N
P
I
K
E
M
A
K
I
AHDNG
A
V
I
V
VDGAQSTP
H
M
K
I
D
V
Q
DLDC
D
F
F
ALSSHKMCGPTG
V
G
V
L
Y
G
K
K
A
L
L
ENM
E
P
A
E
FGG
E
M
I
D
F
V
G
L
Y
E
-
S
T
W
K
EL
P
W
K
FEAGT
P
I
I
A
G
A
I
G
L
G
A
A
I
D
F
L
E
EIG
L
D
E
I
S
R
H
E
H
K
L
A
A
Y
A
L
E
R
F
R
QLD
G
V
T
V
YG-PE-----ER
A
G
L
V
T
F
NLDDVHP
H
D
V
A
T
VLDA-E-
G
I
A
V
RAG
H
H
C
A
Q
P
L
M
K
W
L
D
VTAT
A
R
A
S
F
Y
L
YN
T
E
E
E
I
D
K
L
V
E
A
L
Q
K
T
K
E
Y
F
TNVF
1
PsiBlast_PDB
84.61
51%
-86
- C1 -
4Q76
-
CNIF1_ARATH
A:
[23-427]
-----
V
R
K
D
F
R
I
L
H
Q
E
V
N
G
S
K
L
V
Y
L
D
S
A
A
T
S
Q
K
P
A
A
V
L
D
A
L
Q
N
Y
Y
E
F
Y
N
S
N
V
H
R
G
I
H
Y
L
S
A
K
A
T
D
E
F
E
L
A
R
K
K
V
A
R
F
I
N
A
S
D
S
R
E
I
V
F
T
R
N
A
T
E
A
I
N
L
V
A
Y
S
W
G
L
S
N
L
K
P
G
D
E
V
I
L
T
V
A
E
H
H
S
C
I
V
P
W
Q
I
V
S
Q
K
T
G
A
V
L
K
F
V
T
L
N
E
D
E
V
P
D
I
N
K
L
R
E
L
I
S
P
K
T
K
L
V
A
V
H
H
V
S
N
V
L
A
S
S
L
P
I
E
E
I
V
V
W
A
H
D
V
G
A
K
V
L
V
D
A
C
Q
S
V
P
H
M
V
V
D
V
Q
K
L
N
A
D
F
L
V
A
S
S
H
K
M
C
G
P
T
G
I
G
F
L
Y
G
K
S
D
L
L
H
S
M
P
P
F
L
G
G
G
E
M
I
S
D
V
F
L
D
H
-
S
T
Y
A
E
P
P
S
R
F
E
A
G
T
P
A
I
G
E
A
I
A
L
G
A
A
V
D
Y
L
S
G
I
G
M
P
K
I
H
E
Y
E
V
E
I
G
K
Y
L
Y
E
K
L
S
S
L
P
D
V
R
I
Y
G
-
P
R
P
SE
S
V
H
R
G
A
L
C
S
F
N
V
E
G
L
H
P
T
D
L
A
T
F
L
D
Q
-
Q
H
G
V
A
I
R
S
G
H
H
S
A
Q
P
L
H
R
Y
L
G
V
N
A
S
A
R
A
S
L
Y
F
Y
N
T
K
D
D
V
D
A
F
I
V
A
L
A
D
T
V
S
F
F
N
S
--
88
HHSearch
82.66
53%
-86
- C- -
4Q75
-
CNIF1_ARATH
A:
[22-426]
----
R
V
R
K
D
F
R
I
L
H
Q
E
V
N
G
S
K
L
V
Y
L
D
S
A
A
T
S
Q
K
P
A
A
V
L
D
A
L
Q
N
Y
Y
E
F
Y
N
S
N
V
H
R
G
I
H
Y
L
S
A
K
A
T
D
E
F
E
L
A
R
K
K
V
A
R
F
I
N
A
S
D
S
R
E
I
V
F
T
R
N
A
T
E
A
I
N
L
V
A
Y
S
W
G
L
S
N
L
K
P
G
D
E
V
I
L
T
V
A
E
H
H
S
C
I
V
P
W
Q
I
V
S
Q
K
T
G
A
V
L
K
F
V
T
L
N
E
D
E
V
P
D
I
N
K
L
R
E
L
I
S
P
K
T
K
L
V
A
V
H
H
V
S
N
V
L
A
S
S
L
P
I
E
E
I
V
V
W
A
H
D
V
G
A
K
V
L
V
D
A
C
Q
S
V
P
H
M
V
V
D
V
Q
K
L
N
A
D
F
L
V
A
S
S
H
K
M
C
G
P
T
G
I
G
F
L
Y
G
K
S
D
L
L
H
S
M
P
P
F
L
G
G
G
E
M
I
S
D
V
F
L
D
H
-
S
T
Y
A
E
P
P
S
R
F
E
A
G
T
P
A
I
G
E
A
I
A
L
G
A
A
V
D
Y
L
S
G
I
G
M
P
K
I
H
E
Y
E
V
E
I
G
K
Y
L
Y
E
K
L
S
S
L
P
D
V
R
I
Y
G
-
P
R
PSE
S
V
H
R
G
A
L
C
S
F
N
V
E
G
L
H
P
T
D
L
A
T
F
L
D
Q
Q
H
-
G
V
A
I
R
S
G
H
H
-
A
Q
P
L
H
R
Y
L
G
V
N
A
S
A
R
A
S
L
Y
F
Y
N
T
K
D
D
V
D
A
F
I
V
A
L
A
D
T
V
S
F
F
N
---
5
PsiBlast_PDB
82.14
48%
-92
- C1 -
1C0N
2
SUFS_ECOLI
A:
[3-400]
F
S
V
D
A
V
R
A
D
F
P
V
L
S
R
E
V
N
G
L
P
L
A
Y
L
D
S
A
A
S
A
Q
K
P
S
Q
V
I
D
A
E
A
E
F
Y
R
H
G
Y
A
A
V
H
A
G
A
H
T
L
S
A
Q
A
T
E
K
M
E
N
V
R
K
R
A
S
L
F
I
N
A
R
S
A
E
E
L
V
F
V
R
G
T
T
E
G
I
N
L
V
A
N
S
W
G
N
S
N
V
R
A
G
D
N
I
I
I
S
Q
M
E
H
H
A
N
I
V
P
W
Q
M
L
C
A
R
V
G
A
E
L
R
V
I
P
L
N
P
D
G
T
L
Q
L
E
T
L
P
T
L
F
D
A
A
T
R
L
L
A
I
T
H
V
S
N
V
L
G
T
E
N
P
L
A
E
M
I
T
L
A
H
Q
H
G
A
K
V
L
V
D
G
A
Q
A
V
M
H
H
P
V
D
V
Q
A
L
D
C
D
F
Y
V
F
S
G
H
K
L
Y
G
P
T
G
I
G
I
L
Y
V
K
E
A
L
L
Q
E
M
P
P
W
E
G
G
G
S
M
I
A
T
V
S
L
S
E
G
T
T
W
T
K
A
P
W
R
F
E
A
G
T
P
N
T
G
G
I
I
G
L
G
A
A
L
E
Y
V
S
A
L
G
L
N
N
I
A
E
Y
E
Q
N
L
M
H
Y
A
L
S
Q
L
E
S
V
P
D
L
T
L
Y
G
-
P
Q
-----
A
R
L
G
V
I
A
F
N
L
G
A
H
H
A
Y
D
V
G
S
F
L
D
N
-
Y
-
G
I
A
V
R
T
G
H
H
C
A
M
P
L
M
A
Y
Y
N
V
P
A
M
C
R
A
S
L
A
M
Y
N
T
H
E
E
V
D
R
L
V
T
G
L
Q
R
---------
4
PsiBlast_PDB
82.06
48%
-89
- C1 -
1JF9
1
SUFS_ECOLI
A:
[5-402]
F
S
V
D
K
V
R
A
D
F
P
V
L
S
R
E
V
N
G
L
P
L
A
Y
L
D
S
A
A
S
A
Q
K
P
S
Q
V
I
D
A
E
A
E
F
Y
R
H
G
Y
A
A
V
H
R
G
I
H
T
L
S
A
Q
A
T
E
K
M
E
N
V
R
K
R
A
S
L
F
I
N
A
R
S
A
E
E
L
V
F
V
R
G
T
T
E
G
I
N
L
V
A
N
S
W
G
N
S
N
V
R
A
G
D
N
I
I
I
S
Q
M
E
H
H
A
N
I
V
P
W
Q
M
L
C
A
R
V
G
A
E
L
R
V
I
P
L
N
P
D
G
T
L
Q
L
E
T
L
P
T
L
F
D
E
K
T
R
L
L
A
I
T
H
V
S
N
V
L
G
T
E
N
P
L
A
E
M
I
T
L
A
H
Q
H
G
A
K
V
L
V
D
G
A
Q
A
V
M
H
H
P
V
D
V
Q
A
L
D
C
D
F
Y
V
F
S
G
H
K
L
Y
G
P
T
G
I
G
I
L
Y
V
K
E
A
L
L
Q
E
M
P
P
W
E
G
G
G
S
M
I
A
T
V
S
L
S
E
G
T
T
W
T
K
A
P
W
R
F
E
A
G
T
P
N
T
G
G
I
I
G
L
G
A
A
L
E
Y
V
S
A
L
G
L
N
N
I
A
E
Y
E
Q
N
L
M
H
Y
A
L
S
Q
L
E
S
V
P
D
L
T
L
Y
G
-
P
Q
-----
N
R
L
G
V
I
A
F
N
L
G
K
H
H
A
Y
D
V
G
S
F
L
D
N
-
Y
-
G
I
A
V
R
T
G
H
H
C
A
M
P
L
M
A
Y
Y
N
V
P
A
M
C
R
A
S
L
A
M
Y
N
T
H
E
E
V
D
R
L
V
T
G
L
Q
R
---------
2
PsiBlast_PDB
81.81
51%
-85
- C- -
4Q75
-
CNIF1_ARATH
A:
[23-427]
-----
V
R
K
D
F
R
I
L
H
Q
E
V
N
G
S
K
L
V
Y
L
D
S
A
A
T
S
Q
K
P
A
A
V
L
D
A
L
Q
N
Y
Y
E
F
Y
N
S
N
V
H
R
G
I
H
Y
L
S
A
K
A
T
D
E
F
E
L
A
R
K
K
V
A
R
F
I
N
A
S
D
S
R
E
I
V
F
T
R
N
A
T
E
A
I
N
L
V
A
Y
S
W
G
L
S
N
L
K
P
G
D
E
V
I
L
T
V
A
E
H
H
S
C
I
V
P
W
Q
I
V
S
Q
K
T
G
A
V
L
K
F
V
T
L
N
E
D
E
V
P
D
I
N
K
L
R
E
L
I
S
P
K
T
K
L
V
A
V
H
H
V
S
N
V
L
A
S
S
L
P
I
E
E
I
V
V
W
A
H
D
V
G
A
K
V
L
V
D
A
C
Q
S
V
P
H
M
V
V
D
V
Q
K
L
N
A
D
F
L
V
A
S
S
H
K
M
C
G
P
T
G
I
G
F
L
Y
G
K
S
D
L
L
H
S
M
P
P
F
L
G
G
G
E
M
I
S
D
V
F
L
D
H
-
S
T
Y
A
E
P
P
S
R
F
E
A
G
T
P
A
I
G
E
A
I
A
L
G
A
A
V
D
Y
L
S
G
I
G
M
P
K
I
H
E
Y
E
V
E
I
G
K
Y
L
Y
E
K
L
S
S
L
P
D
V
R
I
Y
G
-
P
R
PSE
S
V
H
R
G
A
L
C
S
F
N
V
E
G
L
H
P
T
D
L
A
T
F
L
D
Q
-
Q
H
G
V
A
I
R
S
G
H
H
-
A
Q
P
L
H
R
Y
L
G
V
N
A
S
A
R
A
S
L
Y
F
Y
N
T
K
D
D
V
D
A
F
I
V
A
L
A
D
T
V
S
F
F
N
S
--
21
PsiBlast_CBE
81.75
50%
-87
- C1 -
1T3I
4
CSD_SYNY3
B:
[13-414]
-----
V
R
Q
D
F
P
I
L
N
Q
E
I
N
G
H
P
L
V
Y
L
D
N
A
A
T
S
Q
K
P
R
A
V
L
E
K
L
M
H
Y
Y
E
N
D
N
A
N
V
---
A
H
Q
L
S
V
R
A
T
D
A
Y
E
A
V
R
N
K
V
A
K
F
I
N
A
R
S
P
R
E
I
V
Y
T
R
N
A
T
E
A
I
N
L
V
A
Y
S
W
G
M
N
N
L
K
A
G
D
E
I
I
T
T
V
M
E
H
H
S
N
L
V
P
W
Q
M
V
A
A
K
T
G
A
V
L
K
F
V
Q
L
D
E
Q
E
S
F
D
L
E
H
F
K
T
L
L
S
E
K
T
K
L
V
T
V
V
H
I
S
N
T
L
G
C
V
N
P
A
E
E
I
A
Q
L
A
H
Q
A
G
A
K
V
L
V
D
A
C
Q
S
A
P
H
Y
P
L
D
V
Q
L
I
D
C
D
W
L
V
A
S
G
H
K
M
C
A
P
T
G
I
G
F
L
Y
G
K
E
E
I
L
E
A
M
P
P
F
F
G
G
G
E
M
I
A
E
V
F
F
D
H
-
F
T
T
G
E
L
P
H
K
F
E
A
G
T
P
A
I
A
E
A
I
A
L
G
A
A
V
D
Y
L
T
D
L
G
M
E
N
I
H
N
Y
E
V
E
L
T
H
Y
L
W
Q
G
L
G
Q
I
P
Q
L
R
L
Y
G
-
P
N
PKHG-
D
R
A
A
L
A
S
F
N
V
A
G
L
H
A
S
D
V
A
T
M
V
D
Q
-
D
-
G
I
A
I
R
S
G
H
H
C
T
Q
P
L
H
R
L
F
D
A
S
G
S
A
R
A
S
L
Y
F
Y
N
T
K
E
E
I
D
L
F
L
Q
S
L
Q
A
T
I
R
F
F
S
---
3
PsiBlast_PDB
81.68
48%
-91
- C1 -
1I29
2
SUFS_ECOLI
A:
[3-400]
F
S
V
D
K
V
R
A
D
F
P
V
L
S
R
E
V
N
G
L
P
L
A
Y
L
D
S
A
A
S
A
Q
K
P
S
Q
V
I
D
A
E
A
E
F
Y
R
H
G
Y
A
A
V
H
R
G
I
H
T
L
S
A
Q
A
T
E
K
M
E
N
V
R
K
R
A
S
L
F
I
N
A
R
S
A
E
E
L
V
F
V
R
G
T
T
E
G
I
N
L
V
A
N
S
W
G
N
S
N
V
R
A
G
D
N
I
I
I
S
Q
M
E
H
H
A
N
I
V
P
W
Q
M
L
C
A
R
V
G
A
E
L
R
V
I
P
L
N
P
D
G
T
L
Q
L
E
T
L
P
T
L
F
D
E
K
T
R
L
L
A
I
T
H
V
S
N
V
L
G
T
E
N
P
L
A
E
M
I
T
L
A
H
Q
H
G
A
K
V
L
V
D
G
A
Q
A
V
M
H
H
P
V
D
V
Q
A
L
D
C
D
F
Y
V
F
S
G
H
K
L
Y
G
P
T
G
I
G
I
L
Y
V
K
E
A
L
L
Q
E
M
P
P
W
E
G
G
G
S
M
I
A
T
V
S
L
S
E
G
T
T
W
T
K
A
P
W
R
F
E
A
G
T
P
N
T
G
G
I
I
G
L
G
A
A
L
E
Y
V
S
A
L
G
L
N
N
I
A
E
Y
E
Q
N
L
M
H
Y
A
L
S
Q
L
E
S
V
P
D
L
T
L
Y
G
-
P
Q
-----
N
R
L
G
V
I
A
F
N
L
G
K
H
H
A
Y
D
V
G
S
F
L
D
N
-
Y
-
G
I
A
V
R
T
G
H
H
C
A
M
P
L
M
A
Y
Y
N
V
P
A
M
C
R
A
S
L
A
M
Y
N
T
H
E
E
V
D
R
L
V
T
G
L
Q
R
---------
6
PsiBlast_PDB
81.07
45%
-92
- C1 -
4W91
1
?
A:
[20-421]
-
D
V
E
A
I
R
R
D
F
P
I
L
S
R
Q
V
H
G
K
T
L
V
Y
L
D
N
G
A
S
A
Q
K
P
Q
S
V
I
D
A
V
T
H
A
Y
A
N
E
Y
A
N
V
H
R
G
L
H
F
L
S
N
A
A
T
D
A
Y
E
K
S
R
E
T
V
R
R
F
L
N
A
G
S
V
D
E
I
V
F
T
K
N
A
T
E
A
I
N
T
V
A
Y
G
Y
G
M
P
F
I
G
E
G
D
E
I
L
L
S
I
M
E
H
H
S
N
I
V
P
W
H
F
I
R
E
R
Q
G
A
K
L
V
F
T
P
V
D
D
N
G
V
F
H
I
E
E
F
E
K
R
L
S
E
R
T
K
L
V
A
I
T
H
M
S
N
T
L
G
T
V
V
P
I
K
K
I
V
E
L
A
H
A
R
G
I
P
V
L
V
D
G
S
Q
G
A
V
H
L
P
V
D
V
Q
D
L
G
C
D
W
Y
V
F
T
G
H
K
V
Y
G
P
S
G
I
G
V
L
Y
G
R
A
Q
M
L
E
K
M
R
P
F
Q
G
G
G
E
M
I
E
E
V
T
E
E
N
-
V
T
Y
N
H
P
P
H
R
F
E
A
G
T
P
P
I
V
Q
A
I
G
L
G
A
A
L
E
Y
M
E
K
I
G
R
H
A
I
L
A
H
E
A
D
L
R
D
Y
A
H
E
R
L
G
R
I
N
S
L
R
I
F
G
N
A
P
-----
D
K
G
A
I
I
S
F
A
L
E
G
I
H
A
H
D
V
S
M
V
I
D
R
-
A
-
G
V
A
V
R
A
G
T
H
C
A
Q
P
L
L
K
R
F
G
V
T
S
T
C
R
A
S
F
A
L
Y
N
T
R
A
E
V
D
A
L
A
E
A
L
E
K
A
R
K
F
F
----
85
HHSearch
80.63
46%
-92
- C1 -
4W91
1
?
A:
[22-420]
---
E
A
I
R
R
D
F
P
I
L
S
R
Q
V
H
G
K
T
L
V
Y
L
D
N
G
A
S
A
Q
K
P
Q
S
V
I
D
A
V
T
H
A
Y
A
N
E
Y
A
N
V
H
R
G
L
H
F
L
S
N
A
A
T
D
A
Y
E
K
S
R
E
T
V
R
R
F
L
N
A
G
S
V
D
E
I
V
F
T
K
N
A
T
E
A
I
N
T
V
A
Y
G
Y
G
M
P
F
I
G
E
G
D
E
I
L
L
S
I
M
E
H
H
S
N
I
V
P
W
H
F
I
R
E
R
Q
G
A
K
L
V
F
T
P
V
D
D
N
G
V
F
H
I
E
E
F
E
K
R
L
S
E
R
T
K
L
V
A
I
T
H
M
S
N
T
L
G
T
V
V
P
I
K
K
I
V
E
L
A
H
A
R
G
I
P
V
L
V
D
G
S
Q
G
A
V
H
L
P
V
D
V
Q
D
L
G
C
D
W
Y
V
F
T
G
H
K
V
Y
G
P
S
G
I
G
V
L
Y
G
R
A
Q
M
L
E
K
M
R
P
F
Q
G
G
G
E
M
I
E
E
V
T
E
E
N
-
V
T
Y
N
H
P
P
H
R
F
E
A
G
T
P
P
I
V
Q
A
I
G
L
G
A
A
L
E
Y
M
E
K
I
G
R
H
A
I
L
A
H
E
A
D
L
R
D
Y
A
H
E
R
L
G
R
I
N
S
L
R
I
F
G
-
N
A
P----
D
K
G
A
I
I
S
F
A
L
E
G
I
H
A
H
D
V
S
M
V
I
D
R
-
A
-
G
V
A
V
R
A
G
T
H
C
A
Q
P
L
L
K
R
F
G
V
T
S
T
C
R
A
S
F
A
L
Y
N
T
R
A
E
V
D
A
L
A
E
A
L
E
K
A
R
K
F
-----
27
PsiBlast_CBE
80.22
45%
-92
- C1 -
4W91
1
?
B:
[20-421]
-
D
V
E
A
I
R
R
D
F
P
I
L
S
R
Q
V
H
G
K
T
L
V
Y
L
D
N
G
A
S
A
Q
K
P
Q
S
V
I
D
A
V
T
H
A
Y
A
N
E
Y
A
N
V
H
R
G
L
H
F
L
S
N
A
A
T
D
A
Y
E
K
S
R
E
T
V
R
R
F
L
N
A
G
S
V
D
E
I
V
F
T
K
N
A
T
E
A
I
N
T
V
A
Y
G
Y
G
M
P
F
I
G
E
G
D
E
I
L
L
S
I
M
E
H
H
S
N
I
V
P
W
H
F
I
R
E
R
Q
G
A
K
L
V
F
T
P
V
D
D
N
G
V
F
H
I
E
E
F
E
K
R
L
S
E
R
T
K
L
V
A
I
T
H
M
S
N
T
L
G
T
V
V
P
I
K
K
I
V
E
L
A
H
A
R
G
I
P
V
L
V
D
G
S
Q
G
A
V
H
L
P
V
D
V
Q
D
L
G
C
D
W
Y
V
F
T
G
H
K
V
Y
G
P
S
G
I
G
V
L
Y
G
R
A
Q
M
L
E
K
M
R
P
F
Q
G
G
G
E
M
I
E
E
V
T
E
E
N
-
V
T
Y
N
H
P
P
H
R
F
E
A
G
T
P
P
I
V
Q
A
I
G
L
G
A
A
L
E
Y
M
E
K
I
G
R
H
A
I
L
A
H
E
A
D
L
R
D
Y
A
H
E
R
L
G
R
I
N
S
L
R
I
F
G
N
A
P
-----
D
K
G
A
I
I
S
F
A
L
E
G
I
H
A
H
D
V
S
M
V
I
D
R
-
A
-
G
V
A
V
R
A
G
T
H
C
A
Q
P
L
L
K
R
F
G
V
T
S
T
C
R
A
S
F
A
L
Y
N
T
R
A
E
V
D
A
L
A
E
A
L
E
K
A
R
K
F
F
----
26
PsiBlast_CBE
80.01
45%
-92
- C1 -
4W91
1
?
C:
[20-421]
-
D
V
E
A
I
R
R
D
F
P
I
L
S
R
Q
V
H
G
K
T
L
V
Y
L
D
N
G
A
S
A
Q
K
P
Q
S
V
I
D
A
V
T
H
A
Y
A
N
E
Y
A
N
V
H
R
G
L
H
F
L
S
N
A
A
T
D
A
Y
E
K
S
R
E
T
V
R
R
F
L
N
A
G
S
V
D
E
I
V
F
T
K
N
A
T
E
A
I
N
T
V
A
Y
G
Y
G
M
P
F
I
G
E
G
D
E
I
L
L
S
I
M
E
H
H
S
N
I
V
P
W
H
F
I
R
E
R
Q
G
A
K
L
V
F
T
P
V
D
D
N
G
V
F
H
I
E
E
F
E
K
R
L
S
E
R
T
K
L
V
A
I
T
H
M
S
N
T
L
G
T
V
V
P
I
K
K
I
V
E
L
A
H
A
R
G
I
P
V
L
V
D
G
S
Q
G
A
V
H
L
P
V
D
V
Q
D
L
G
C
D
W
Y
V
F
T
G
H
K
V
Y
G
P
S
G
I
G
V
L
Y
G
R
A
Q
M
L
E
K
M
R
P
F
Q
G
G
G
E
M
I
E
E
V
T
E
E
N
-
V
T
Y
N
H
P
P
H
R
F
E
A
G
T
P
P
I
V
Q
A
I
G
L
G
A
A
L
E
Y
M
E
K
I
G
R
H
A
I
L
A
H
E
A
D
L
R
D
Y
A
H
E
R
L
G
R
I
N
S
L
R
I
F
G
N
A
P
-----
D
K
G
A
I
I
S
F
A
L
E
G
I
H
A
H
D
V
S
M
V
I
D
R
-
A
-
G
V
A
V
R
A
G
T
H
C
A
Q
P
L
L
K
R
F
G
V
T
S
T
C
R
A
S
F
A
L
Y
N
T
R
A
E
V
D
A
L
A
E
A
L
E
K
A
R
K
F
F
----
84
HHSearch
79.80
43%
-110
- C1 -
4LW2
2
CSDA_ECOLI
A:
[8-402]
-
N
P
A
Q
F
R
A
Q
F
P
A
L
Q
-----
D
A
G
V
Y
L
D
S
A
A
T
A
L
K
P
E
A
V
V
E
A
T
Q
Q
F
Y
S
L
S
A
G
N
V
H
R
S
Q
F
A
E
A
Q
R
L
T
A
R
Y
E
A
A
R
E
K
V
A
Q
L
L
N
A
P
D
D
K
T
I
V
W
T
R
G
T
T
E
S
I
N
M
V
A
Q
C
Y
A
R
P
R
L
Q
P
G
D
E
I
I
V
S
V
A
E
H
H
A
N
L
V
P
W
L
M
V
A
Q
Q
T
G
A
K
V
V
K
L
P
L
N
A
Q
R
L
P
D
V
D
L
L
P
E
L
I
T
P
R
S
R
I
L
A
L
G
Q
M
S
N
V
T
G
G
C
P
D
L
A
R
A
I
T
F
A
H
S
A
G
M
V
V
M
V
D
G
A
Q
G
A
V
H
F
P
A
D
V
Q
Q
L
D
I
D
F
Y
A
F
S
G
H
K
L
Y
G
P
T
G
I
G
V
L
Y
G
K
S
E
L
L
E
A
M
S
P
W
L
G
G
G
K
M
V
H
E
V
S
F
D
G
-
F
T
T
Q
S
A
P
W
K
L
E
A
G
T
P
N
V
A
G
V
I
G
L
S
A
A
L
E
W
L
A
D
Y
D
I
N
Q
A
E
S
W
S
R
S
L
A
T
L
A
E
D
A
L
A
K
R
P
G
F
R
S
F
R
-
C
------
Q
D
S
S
L
L
A
F
D
F
A
G
V
H
H
S
D
M
V
T
L
L
A
E
-
Y
-
G
I
A
L
R
A
G
Q
H
C
A
Q
P
L
L
A
E
L
G
V
T
G
T
L
R
A
S
F
A
P
Y
N
T
K
S
D
V
D
A
L
V
N
A
V
D
R
A
L
E
L
L
----
8
PsiBlast_PDB
79.32
41%
-115
- C1 -
4LW4
2
CSDA_ECOLI
A:
[7-403]
F
N
P
A
Q
F
R
A
Q
F
P
A
L
Q
D
A
G
-----
V
Y
L
D
S
A
A
T
A
L
K
P
E
A
V
V
E
A
T
Q
Q
F
Y
S
L
S
A
G
------
F
A
E
A
Q
R
L
T
A
R
Y
E
A
A
R
E
K
V
A
Q
L
L
N
A
P
D
D
K
T
I
V
W
T
R
G
T
T
E
S
I
N
M
V
A
Q
C
Y
A
R
P
R
L
Q
P
G
D
E
I
I
V
S
V
A
E
H
H
A
N
L
V
P
W
L
M
V
A
Q
Q
T
G
A
K
V
V
K
L
P
L
N
A
Q
R
L
P
D
V
D
L
L
P
E
L
I
T
P
R
S
R
I
L
A
L
G
Q
M
S
N
V
T
G
G
C
P
D
L
A
R
A
I
T
F
A
H
S
A
G
M
V
V
M
V
D
G
A
Q
G
A
V
H
F
P
A
D
V
Q
Q
L
D
I
D
F
Y
A
F
S
G
H
K
L
Y
G
P
T
G
I
G
V
L
Y
G
K
S
E
L
L
E
A
M
S
P
W
L
G
G
G
K
M
V
H
E
V
S
F
D
G
-
F
T
T
Q
S
A
P
W
K
L
E
A
G
T
P
N
V
A
G
V
I
G
L
S
A
A
L
E
W
L
A
D
Y
D
I
N
Q
A
E
S
W
S
R
S
L
A
T
L
A
E
D
A
L
A
K
R
P
G
F
R
S
F
R
-
C
Q
-----
D
-
S
S
L
L
A
F
D
F
A
G
V
H
H
S
D
M
V
T
L
L
A
E
-
Y
-
G
I
A
L
R
A
G
Q
H
C
A
Q
P
L
L
A
E
L
G
V
T
G
T
L
R
A
S
F
A
P
Y
N
T
K
S
D
V
D
A
L
V
N
A
V
D
R
A
L
E
L
L
V
---
28
PsiBlast_CBE
79.27
41%
-111
- C1 -
4LW4
2
CSDA_ECOLI
B:
[7-403]
F
N
P
A
Q
F
R
A
Q
F
P
A
L
Q
D
A
G
-----
V
Y
L
D
S
A
A
T
A
L
K
P
E
A
V
V
E
A
T
Q
Q
F
Y
S
L
S
A
G
N
V
H
R
S
Q
F
A
E
A
Q
R
L
T
A
R
Y
E
A
A
R
E
K
V
A
Q
L
L
N
A
P
D
D
K
T
I
V
W
T
R
G
T
T
E
S
I
N
M
V
A
Q
C
Y
A
R
P
R
L
Q
P
G
D
E
I
I
V
S
V
A
E
H
H
A
N
L
V
P
W
L
M
V
A
Q
Q
T
G
A
K
V
V
K
L
P
L
N
A
Q
R
L
P
D
V
D
L
L
P
E
L
I
T
P
R
S
R
I
L
A
L
G
Q
M
S
N
V
T
G
G
C
P
D
L
A
R
A
I
T
F
A
H
S
A
G
M
V
V
M
V
D
G
A
Q
G
A
V
H
F
P
A
D
V
Q
Q
L
D
I
D
F
Y
A
F
S
G
H
K
L
Y
G
P
T
G
I
G
V
L
Y
G
K
S
E
L
L
E
A
M
S
P
W
L
G
G
G
K
M
V
H
E
V
S
F
D
G
-
F
T
T
Q
S
A
P
W
K
L
E
A
G
T
P
N
V
A
G
V
I
G
L
S
A
A
L
E
W
L
A
D
Y
D
I
N
Q
A
E
S
W
S
R
S
L
A
T
L
A
E
D
A
L
A
K
R
P
G
F
R
S
F
R
-
C
Q
-----
D
-
S
S
L
L
A
F
D
F
A
G
V
H
H
S
D
M
V
T
L
L
A
E
-
Y
-
G
I
A
L
R
A
G
Q
H
C
A
Q
P
L
L
A
E
L
G
V
T
G
T
L
R
A
S
F
A
P
Y
N
T
K
S
D
V
D
A
L
V
N
A
V
D
R
A
L
E
L
L
V
---
7
PsiBlast_PDB
79.26
41%
-110
- C1 -
4LW2
2
CSDA_ECOLI
A:
[7-403]
F
N
P
A
Q
F
R
A
Q
F
P
A
L
Q
D
A
G
-----
V
Y
L
D
S
A
A
T
A
L
K
P
E
A
V
V
E
A
T
Q
Q
F
Y
S
L
S
A
G
N
V
H
R
S
Q
F
A
E
A
Q
R
L
T
A
R
Y
E
A
A
R
E
K
V
A
Q
L
L
N
A
P
D
D
K
T
I
V
W
T
R
G
T
T
E
S
I
N
M
V
A
Q
C
Y
A
R
P
R
L
Q
P
G
D
E
I
I
V
S
V
A
E
H
H
A
N
L
V
P
W
L
M
V
A
Q
Q
T
G
A
K
V
V
K
L
P
L
N
A
Q
R
L
P
D
V
D
L
L
P
E
L
I
T
P
R
S
R
I
L
A
L
G
Q
M
S
N
V
T
G
G
C
P
D
L
A
R
A
I
T
F
A
H
S
A
G
M
V
V
M
V
D
G
A
Q
G
A
V
H
F
P
A
D
V
Q
Q
L
D
I
D
F
Y
A
F
S
G
H
K
L
Y
G
P
T
G
I
G
V
L
Y
G
K
S
E
L
L
E
A
M
S
P
W
L
G
G
G
K
M
V
H
E
V
S
F
D
G
-
F
T
T
Q
S
A
P
W
K
L
E
A
G
T
P
N
V
A
G
V
I
G
L
S
A
A
L
E
W
L
A
D
Y
D
I
N
Q
A
E
S
W
S
R
S
L
A
T
L
A
E
D
A
L
A
K
R
P
G
F
R
S
F
R
-
C
Q
-----
D
-
S
S
L
L
A
F
D
F
A
G
V
H
H
S
D
M
V
T
L
L
A
E
-
Y
-
G
I
A
L
R
A
G
Q
H
C
A
Q
P
L
L
A
E
L
G
V
T
G
T
L
R
A
S
F
A
P
Y
N
T
K
S
D
V
D
A
L
V
N
A
V
D
R
A
L
E
L
L
V
---
29
PsiBlast_CBE
79.03
41%
-113
- C1 -
4LW2
3
CSDA_ECOLI
C:
[7-403]
F
N
P
A
Q
F
R
A
Q
F
P
A
L
Q
D
A
G
-----
V
Y
L
D
S
A
A
T
A
L
K
P
E
A
V
V
E
A
T
Q
Q
F
Y
S
L
S
A
G
N
V
H
R
S
Q
F
A
E
A
Q
R
L
T
A
R
Y
E
A
A
R
E
K
V
A
Q
L
L
N
A
P
D
D
K
T
I
V
W
T
R
G
T
T
E
S
I
N
M
V
A
Q
C
Y
A
R
P
R
L
Q
P
G
D
E
I
I
V
S
V
A
E
H
H
A
N
L
V
P
W
L
M
V
A
Q
Q
T
G
A
K
V
V
K
L
P
L
N
A
Q
R
L
P
D
V
D
L
L
P
E
L
I
T
P
R
S
R
I
L
A
L
G
Q
M
S
N
V
T
G
G
C
P
D
L
A
R
A
I
T
F
A
H
S
A
G
M
V
V
M
V
D
G
A
Q
G
A
V
H
F
P
A
D
V
Q
Q
L
D
I
D
F
Y
A
F
S
G
H
K
L
Y
G
P
T
G
I
G
V
L
Y
G
K
S
E
L
L
E
A
M
S
P
W
L
G
G
G
K
M
V
H
E
V
S
F
D
G
-
F
T
T
Q
S
A
P
W
K
L
E
A
G
T
P
N
V
A
G
V
I
G
L
S
A
A
L
E
W
L
A
D
Y
D
I
N
Q
A
E
S
W
S
R
S
L
A
T
L
A
E
D
A
L
A
K
R
P
G
F
R
S
F
R
-
C
Q
-----
D
-
S
S
L
L
A
F
D
F
A
G
V
H
H
S
D
M
V
T
L
L
A
E
-
Y
-
G
I
A
L
R
A
G
Q
H
C
A
Q
P
L
L
A
E
L
G
V
T
G
T
L
R
A
S
F
A
P
Y
N
T
K
S
D
V
D
A
L
V
N
A
V
D
R
A
L
E
L
L
V
---
30
PsiBlast_CBE
79.02
41%
-108
- C1 -
4LW2
3
CSDA_ECOLI
B:
[7-403]
F
N
P
A
Q
F
R
A
Q
F
P
A
L
Q
D
A
G
-----
V
Y
L
D
S
A
A
T
A
L
K
P
E
A
V
V
E
A
T
Q
Q
F
Y
S
L
S
A
G
N
V
H
R
S
Q
F
A
E
A
Q
R
L
T
A
R
Y
E
A
A
R
E
K
V
A
Q
L
L
N
A
P
D
D
K
T
I
V
W
T
R
G
T
T
E
S
I
N
M
V
A
Q
C
Y
A
R
P
R
L
Q
P
G
D
E
I
I
V
S
V
A
E
H
H
A
N
L
V
P
W
L
M
V
A
Q
Q
T
G
A
K
V
V
K
L
P
L
N
A
Q
R
L
P
D
V
D
L
L
P
E
L
I
T
P
R
S
R
I
L
A
L
G
Q
M
S
N
V
T
G
G
C
P
D
L
A
R
A
I
T
F
A
H
S
A
G
M
V
V
M
V
D
G
A
Q
G
A
V
H
F
P
A
D
V
Q
Q
L
D
I
D
F
Y
A
F
S
G
H
K
L
Y
G
P
T
G
I
G
V
L
Y
G
K
S
E
L
L
E
A
M
S
P
W
L
G
G
G
K
M
V
H
E
V
S
F
D
G
-
F
T
T
Q
S
A
P
W
K
L
E
A
G
T
P
N
V
A
G
V
I
G
L
S
A
A
L
E
W
L
A
D
Y
D
I
N
Q
A
E
S
W
S
R
S
L
A
T
L
A
E
D
A
L
A
K
R
P
G
F
R
S
F
R
-
C
Q
-----
D
-
S
S
L
L
A
F
D
F
A
G
V
H
H
S
D
M
V
T
L
L
A
E
-
Y
-
G
I
A
L
R
A
G
Q
H
C
A
Q
P
L
L
A
E
L
G
V
T
G
T
L
R
A
S
F
A
P
Y
N
T
K
S
D
V
D
A
L
V
N
A
V
D
R
A
L
E
L
L
V
---
22
PsiBlast_CBE
71.72
45%
-72
- C1 -
4W91
1
?
I:
[20-421]
-
D
V
E
A
I
R
R
D
F
P
I
L
S
R
Q
V
H
G
K
T
L
V
Y
L
D
N
G
A
S
A
Q
K
P
Q
S
V
I
D
A
V
T
H
A
Y
A
N
E
Y
A
N
V
H
---
H
F
L
S
N
A
A
T
D
A
Y
E
K
S
R
E
T
V
R
R
F
L
N
A
G
S
V
D
E
I
V
F
T
K
N
A
T
E
A
I
N
T
V
A
Y
G
Y
G
M
P
F
I
G
E
G
D
E
I
L
L
S
I
M
E
H
H
S
N
I
V
P
W
H
F
I
R
E
R
Q
G
A
K
L
V
F
T
P
V
D
D
N
G
V
F
H
I
E
E
F
E
K
R
L
S
E
R
T
K
L
V
A
I
T
H
M
S
N
T
L
G
T
V
V
P
I
K
K
I
V
E
L
A
H
A
R
G
I
P
V
L
V
D
G
S
Q
G
A
V
H
L
P
V
D
V
Q
D
L
G
C
D
W
Y
V
F
T
G
H
-
V
Y
G
P
S
G
I
G
V
L
Y
G
R
A
Q
M
L
E
K
M
R
P
F
Q
G
G
G
E
M
I
E
E
V
T
E
E
N
-
V
T
Y
N
H
P
P
H
R
F
E
A
G
T
P
P
I
V
Q
A
I
G
L
G
A
A
L
E
Y
M
E
K
I
G
R
H
A
I
L
A
H
E
A
D
L
R
D
Y
A
H
E
R
L
G
R
I
N
S
L
R
I
F
G
--------
D
K
G
A
I
I
S
F
A
L
E
G
I
H
A
H
D
V
S
M
V
I
D
R
-
A
-
G
V
A
V
R
A
G
T
H
C
A
Q
P
L
L
K
R
F
G
V
T
S
T
C
R
A
S
F
A
L
Y
N
T
R
A
E
V
D
A
L
A
E
A
L
E
K
A
R
K
F
F
----
25
PsiBlast_CBE
70.15
45%
-56
- C1 -
4W91
1
?
D:
[20-421]
-
D
V
E
A
I
R
R
D
F
P
I
L
S
R
Q
V
H
G
K
T
L
V
Y
L
D
N
G
A
S
A
Q
K
P
Q
S
V
I
D
A
V
T
H
A
Y
A
N
E
Y
A
N
V
H
R
G
L
H
F
L
S
N
A
A
T
D
A
Y
E
K
S
R
E
T
V
R
R
F
L
N
A
G
S
V
D
E
I
V
F
T
K
N
A
T
E
A
I
N
T
V
A
Y
G
Y
G
M
P
F
I
G
E
G
D
E
I
L
L
S
I
M
E
H
H
S
N
I
V
P
W
H
F
I
R
E
R
Q
G
A
K
L
V
F
T
P
V
D
D
N
G
V
F
H
I
E
E
F
E
K
R
L
S
E
R
T
K
L
V
A
I
T
H
M
S
N
T
L
G
T
V
V
P
I
K
K
I
V
E
L
A
H
A
R
G
I
P
V
L
V
D
G
S
Q
G
A
V
H
L
P
V
D
V
Q
D
L
G
C
D
W
Y
V
F
T
G
H
-
V
Y
G
P
S
G
I
G
V
L
Y
G
R
A
Q
M
L
E
K
M
R
P
F
Q
G
G
G
E
M
I
E
E
V
T
E
E
N
-
V
T
Y
N
H
P
P
H
R
F
E
A
G
T
P
P
I
V
Q
A
I
G
L
G
A
A
L
E
Y
M
E
K
I
G
R
H
A
I
L
A
H
E
A
D
L
R
D
Y
A
H
E
R
L
G
R
I
N
S
L
R
I
F
G
N
A
P
-----
D
K
G
A
I
I
S
F
A
L
E
G
I
H
A
H
D
V
S
M
V
I
D
R
-
A
-
G
V
A
V
R
A
G
T
H
C
A
Q
P
L
L
K
R
F
G
V
T
S
T
C
R
A
S
F
A
L
Y
N
T
R
A
E
V
D
A
L
A
E
A
L
E
K
A
R
K
F
F
----
24
PsiBlast_CBE
70.12
45%
-56
- C1 -
4W91
1
?
E:
[20-421]
-
D
V
E
A
I
R
R
D
F
P
I
L
S
R
Q
V
H
G
K
T
L
V
Y
L
D
N
G
A
S
A
Q
K
P
Q
S
V
I
D
A
V
T
H
A
Y
A
N
E
Y
A
N
V
H
R
G
L
H
F
L
S
N
A
A
T
D
A
Y
E
K
S
R
E
T
V
R
R
F
L
N
A
G
S
V
D
E
I
V
F
T
K
N
A
T
E
A
I
N
T
V
A
Y
G
Y
G
M
P
F
I
G
E
G
D
E
I
L
L
S
I
M
E
H
H
S
N
I
V
P
W
H
F
I
R
E
R
Q
G
A
K
L
V
F
T
P
V
D
D
N
G
V
F
H
I
E
E
F
E
K
R
L
S
E
R
T
K
L
V
A
I
T
H
M
S
N
T
L
G
T
V
V
P
I
K
K
I
V
E
L
A
H
A
R
G
I
P
V
L
V
D
G
S
Q
G
A
V
H
L
P
V
D
V
Q
D
L
G
C
D
W
Y
V
F
T
G
H
-
V
Y
G
P
S
G
I
G
V
L
Y
G
R
A
Q
M
L
E
K
M
R
P
F
Q
G
G
G
E
M
I
E
E
V
T
E
E
N
-
V
T
Y
N
H
P
P
H
R
F
E
A
G
T
P
P
I
V
Q
A
I
G
L
G
A
A
L
E
Y
M
E
K
I
G
R
H
A
I
L
A
H
E
A
D
L
R
D
Y
A
H
E
R
L
G
R
I
N
S
L
R
I
F
G
N
A
P
-----
D
K
G
A
I
I
S
F
A
L
E
G
I
H
A
H
D
V
S
M
V
I
D
R
-
A
-
G
V
A
V
R
A
G
T
H
C
A
Q
P
L
L
K
R
F
G
V
T
S
T
C
R
A
S
F
A
L
Y
N
T
R
A
E
V
D
A
L
A
E
A
L
E
K
A
R
K
F
F
----