@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu32980: (2016-07-25 )
MNKKIAIVTGASSGFGLLAAVKLARSFFVIATSRQPEKAEQLRELAAAHNVSDSIHITALDVTDEQSIVSFGKAVSAYAPIDLLVNNAGTAYGGFIEDVPMEHFRQQFETNVFGVIHVTKTVLPYIRKHGGAKIINVSSISGLTGFPALSPYVSSKHALEGFSESLRIELLPFGIETALIEPGSYKTSIWSTSLSNFMSVPADDSAYHQYYKKILSYVQKNGEESGDPQEVADLIYQLATKQHIKNLRYPIGKGIKLTLLFRSLFPWSAWESILKKKLFS
Atome Classification :
(28 SA)
.........10........20.-..----..----.--..30........40........50.-.......60..---......70-....-....80........90..-.-.....100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.........210.......220.......230.......240.......250.......260.......270.......280
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNK
K
I
A
I
V
TGASS
G
F
G
L
L
A
A
V
K
-
L
A
----
R
S
----
F
--
F
V
I
A
TSRQ
P
E
K
A
E
Q
L
R
E
L
A
A
AHNVS-D
S
I
H
I
T
A
L
DVT---D
E
Q
S
I
V
S
F
-
G
K
A
V
-SAYA
P
I
D
L
L
VNNAGTAYG-G-
F
I
EDV
P
M
E
H
F
R
Q
Q
FETN
V
F
G
V
I
H
V
T
K
T
V
L
P
Y
I
R
KHGG
A
K
I
I
N
V
SSISGLTGFPAL
S
P
Y
VS
S
K
H
A
L
E
GF
S
E
S
L
R
I
E
L
L
PFGI
E
T
A
L
IEPGS
Y
K
T
S
I
W
S
T
S
L
S
N
F
MSV--PAD
D
S
A
Y
H
Q
Y
Y
K
K
I
L
S
Y
V
Q
KNGEESG
D
P
Q
E
V
A
D
L
I
Y
Q
L
A
T
K
Q
H
I
K
NLRYPIGKG
I
K
L
T
L
L
F
R
SLF
P
W
S
A
W
E
S
I
L
K
K
KLFS
20
PsiBlast_PDB
89.90
32%
-28
- C1 -
1FDT
3
DHB1_HUMAN
A:
[2-253]
--
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
-
L
A
S
DPS
Q
S
----
F
--
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
P
P
G
S
L
E
T
L
Q
L
D
V
R
---
D
S
K
S
V
A
A
A
-
R
E
R
V
-
T
E
-
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
-
G
-
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
V
L
G
S
P
E
E
V
L
D
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
H
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
-
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
-------------------------------
3
PsiBlast_PDB
89.63
32%
-34
- C1 -
1A27
2
DHB1_HUMAN
A:
[2-253]
--
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
-
L
A
S
DPS
Q
S
----
F
--
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
P
P
G
S
L
E
T
L
Q
L
D
V
R
---
D
S
K
S
V
A
A
A
-
R
E
R
V
-
T
E
-
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
-
G
-
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
V
L
G
S
P
E
E
V
L
D
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
H
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
-
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
-------------------------------
9
PsiBlast_PDB
88.90
32%
-29
- C1 -
1JTV
1
DHB1_HUMAN
A:
[2-253]
--
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
-
L
A
S
DPS
Q
S
----
F
--
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
P
P
G
S
L
E
T
L
Q
L
D
V
R
---
D
S
K
S
V
A
A
A
-
R
E
R
V
-
T
E
-
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
-
G
-
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
-------
G
S
P
E
E
V
L
D
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
H
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
-
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
-------------------------------
8
PsiBlast_PDB
88.85
32%
-29
- C1 -
1I5R
3
DHB1_HUMAN
A:
[2-253]
--
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
-
L
A
S
DPS
Q
S
----
F
--
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
P
P
G
S
L
E
T
L
Q
L
D
V
R
---
D
S
K
S
V
A
A
A
-
R
E
R
V
-
T
E
-
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
-
G
-
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
V
L
G
S
P
E
E
V
L
D
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
H
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
-
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
-------------------------------
7
PsiBlast_PDB
88.68
32%
-27
- C1 -
3DHE
1
DHB1_HUMAN
A:
[2-253]
--
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
-
L
A
S
DPS
Q
S
----
F
--
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
P
P
G
S
L
E
T
L
Q
L
D
V
R
---
D
S
K
S
V
A
A
A
-
R
E
R
V
-
T
E
-
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
-
G
-
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
V
L
G
S
P
E
E
V
L
D
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
H
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
-
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
-------------------------------
34
PsiBlast_CBE
88.33
32%
-30
- C1 -
1FDU
3
DHB1_HUMAN
C:
[2-253]
--
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
-
L
A
S
DPS
Q
S
----
F
--
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
P
P
G
S
L
E
T
L
Q
L
D
V
R
---
D
S
K
S
V
A
A
A
-
R
E
R
V
-
T
E
-
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
-
G
-
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
V
L
G
S
P
E
E
V
L
D
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
L
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
-
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
-------------------------------
6
PsiBlast_PDB
88.10
32%
-23
- C1 -
1DHT
1
DHB1_HUMAN
A:
[2-253]
--
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
-
L
A
S
DPS
Q
S
----
F
--
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
P
P
G
S
L
E
T
L
Q
L
D
V
R
---
D
S
K
S
V
A
A
A
-
R
E
R
V
-
T
E
-
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
-
G
-
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
V
L
G
S
P
E
E
V
L
D
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
H
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
-
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
-------------------------------
19
PsiBlast_PDB
88.07
32%
-34
- C1 -
1FDS
1
DHB1_HUMAN
A:
[2-253]
--
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
-
L
A
S
DPS
Q
S
----
F
--
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
P
P
G
S
L
E
T
L
Q
L
D
V
R
---
D
S
K
S
V
A
A
A
-
R
E
R
V
-
T
E
-
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
-
G
-
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
-----
V
L
G
S
P
E
E
V
L
D
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
H
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
-
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
-------------------------------
15
PsiBlast_PDB
87.51
32%
-33
- C1 -
3HB4
1
DHB1_HUMAN
X:
[2-253]
--
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
-
L
A
SDPS
Q
S
----
F
--
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
P
P
G
S
L
E
T
L
Q
L
D
V
R
---
D
S
K
S
V
A
A
A
-
R
E
R
V
-
T
E
-
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
-
G
-
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
V
L
G
S
P
E
E
V
LD
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
H
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
-
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
-------------------------------
16
PsiBlast_PDB
87.29
32%
-30
- C1 -
3HB5
2
DHB1_HUMAN
X:
[2-253]
--
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
-
L
A
SDPS
Q
S
----
F
--
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
P
P
G
S
L
E
T
L
Q
L
D
V
R
---
D
S
K
S
V
A
A
A
-
R
E
R
V
-
T
E
-
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
-
G
-
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
V
L
G
S
P
E
E
V
LD
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
H
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
-
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
-------------------------------
28
PsiBlast_CBE
87.25
32%
-30
- C1 -
3KLM
2
DHB1_HUMAN
X:
[2-253]
--
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
-
L
A
SDPS
Q
S
----
F
--
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
P
P
G
S
L
E
T
L
Q
L
D
V
R
---
D
S
K
S
V
A
A
A
-
R
E
R
V
-
T
E
-
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
-
G
-
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
-------
G
S
P
E
E
V
LD
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
H
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
-
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
-------------------------------
14
PsiBlast_PDB
87.25
32%
-30
- C1 -
3DEY
2
DHB1_HUMAN
X:
[2-253]
--
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
-
L
A
SDPS
Q
S
----
F
--
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
P
P
G
S
L
E
T
L
Q
L
D
V
R
---
D
S
K
S
V
A
A
A
-
R
E
R
V
-
T
E
-
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
-
G
-
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
-------
G
S
P
E
E
V
LD
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
H
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
-
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
-------------------------------
5
PsiBlast_PDB
87.17
32%
-34
- C1 -
1EQU
2
DHB1_HUMAN
A:
[2-253]
--
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
-
L
A
S
DPS
Q
S
----
F
--
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
P
P
G
S
L
E
T
L
Q
L
D
V
R
---
D
S
K
S
V
A
A
A
-
R
E
R
V
-
T
E
-
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
-
G
-
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
V
L
G
S
P
E
E
V
L
D
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
H
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
-
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
-------------------------------
10
PsiBlast_PDB
87.15
32%
-26
- C1 -
1QYV
1
DHB1_HUMAN
A:
[2-253]
--
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
-
L
A
S
DPS
Q
S
----
F
--
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
P
P
G
S
L
E
T
L
Q
L
D
V
R
---
D
S
K
S
V
A
A
A
-
R
E
R
V
-
T
E
-
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
-
G
-
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
--------
S
P
E
E
V
L
D
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
H
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
-
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
-------------------------------
11
PsiBlast_PDB
85.79
32%
-28
- C1 -
1QYW
2
DHB1_HUMAN
A:
[2-253]
--
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
-
L
A
S
DPS
Q
S
----
F
--
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
P
P
G
S
L
E
T
L
Q
L
D
V
R
---
D
S
K
S
V
A
A
A
-
R
E
R
V
-
T
E
-
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
-
G
-
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
--------
S
P
E
E
V
L
D
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
H
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
-
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
-------------------------------
32
PsiBlast_CBE
85.74
32%
-34
- C1 -
1FDV
3
DHB1_HUMAN
A:
[2-253]
--
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
-
L
A
S
DPS
Q
S
----
F
--
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
P
P
G
S
L
E
T
L
Q
L
D
V
R
---
D
S
K
S
V
A
A
A
-
R
E
R
V
-
T
E
-
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
-
G
-
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
V
L
G
S
P
E
E
V
L
D
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
L
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
-
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
-------------------------------
36
PsiBlast_CBE
85.37
32%
-27
- C1 -
1FDU
3
DHB1_HUMAN
A:
[2-253]
--
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
-
L
A
S
DPS
Q
S
----
F
--
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
P
P
G
S
L
E
T
L
Q
L
D
V
R
---
D
S
K
S
V
A
A
A
-
R
E
R
V
-
T
E
-
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
-
G
-
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
V
L
G
----
V
LD
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
L
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
-
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
-------------------------------
30
PsiBlast_CBE
85.14
32%
-33
- C1 -
1FDV
3
DHB1_HUMAN
C:
[2-253]
--
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
-
L
A
SDPS
Q
S
----
F
--
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
P
P
G
S
L
E
T
L
Q
L
D
V
R
---
D
S
K
S
V
A
A
A
-
R
E
R
V
-
T
E
-
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
-
G
-
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
V
L
G
S
P
E
E
V
LD
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
L
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
-
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
-------------------------------
4
PsiBlast_PDB
85.02
32%
-30
- C1 -
1FDW
1
DHB1_HUMAN
A:
[2-253]
--
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
-
L
A
S
DPS
Q
S
----
F
--
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
P
P
G
S
L
E
T
L
Q
L
D
V
R
---
D
S
K
S
V
A
A
A
-
R
E
R
V
-
T
E
-
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
-
G
-
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
------
G
S
P
E
E
V
L
D
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
Q
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
-
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
-------------------------------
17
PsiBlast_PDB
84.94
32%
-28
- C1 -
3KLP
1
DHB1_HUMAN
X:
[2-253]
--
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
-
L
A
SDPS
Q
S
----
F
--
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
P
P
G
S
L
E
T
L
Q
L
D
V
R
---
D
S
K
S
V
A
A
A
-
R
E
R
V
-
T
E
-
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
-
G
-
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
---------
S
P
E
E
V
LD
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
H
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
-
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
-------------------------------
42
PsiBlast_CBE
54.47
32%
-34
- C1 -
4QEC
3
?
A:
[2-187]
--
K
K
N
V
L
I
T
G
G
F
K
G
I
G
K
Q
V
A
L
E
F
L
K
----
N
D
----
Y
--
H
V
C
I
T
S
R
Y
F
E
K
E
K
R
I
P
H
L
F
S
S
Y
--
E
-
E
N
I
S
F
Y
Q
L
D
V
T
---
D
E
E
Q
V
N
E
I
I
N
K
I
V
-
K
K
F
G
R
L
D
V
L
V
N
N
A
G
I
S
L
S
D
G
-
L
L
T
E
T
K
T
T
D
F
N
K
M
I
N
T
N
I
L
G
T
Y
F
C
M
K
Y
A
L
K
H
M
Q
K
V
S
C
G
A
I
V
N
I
S
S
I
T
G
L
S
G
F
P
Y
S
I
L
Y
G
S
T
K
H
A
V
I
G
L
T
K
G
A
A
V
E
F
A
D
K
G
I
K
I
N
A
V
A
P
G
I
I
K
T
-----------------------------------------------------------------------------------------------
38
PsiBlast_CBE
54.24
33%
15
- C1 -
3RKU
1
YM71_YEAST
C:
[31-223]
L
A
K
K
T
V
L
I
T
G
A
S
A
G
I
G
K
A
T
A
L
E
-
Y
L
----
E
A
SNGD
M
--
K
L
I
L
A
A
R
R
L
E
K
L
E
E
L
K
K
T
I
D
Q
E
F
P
N
-
A
K
V
H
V
A
Q
L
D
I
T
---
Q
A
E
K
I
K
P
F
-
I
E
N
L
P
Q
E
F
K
D
I
D
I
L
V
N
N
A
G
K
A
L
G
-
S
D
R
V
G
Q
I
A
T
E
D
I
Q
D
V
F
D
T
N
V
T
A
L
I
N
I
T
Q
A
V
L
P
I
F
Q
A
K
N
S
G
D
I
V
N
L
G
S
I
A
G
R
D
A
Y
P
T
G
S
I
Y
C
A
S
K
F
A
V
G
A
F
T
D
S
L
R
K
E
L
I
N
T
K
I
R
V
I
L
I
A
P
G
L
V
E
T
-----------------------------------------------------------------------------------------------
40
PsiBlast_CBE
54.21
33%
16
- C1 -
3RKU
1
YM71_YEAST
A:
[31-223]
L
A
K
K
T
V
L
I
T
G
A
S
A
G
I
G
K
A
T
A
L
E
-
Y
L
----
E
A
S
NGD
M
--
K
L
I
L
A
A
R
R
L
E
K
L
E
E
L
K
K
T
I
D
Q
E
F
P
N
-
A
K
V
H
V
A
Q
L
D
I
T
---
Q
A
E
K
I
K
P
F
-
I
E
N
L
P
Q
E
F
K
D
I
D
I
L
V
N
N
A
G
K
A
L
G
-
S
D
R
V
G
Q
I
A
T
E
D
I
Q
D
V
F
D
T
N
V
T
A
L
I
N
I
T
Q
A
V
L
P
I
F
Q
A
K
N
S
G
D
I
V
N
L
G
S
I
A
G
R
D
A
Y
P
T
G
S
I
Y
C
A
S
K
F
A
V
G
A
F
T
D
S
L
R
K
E
L
I
N
T
K
I
R
V
I
L
I
A
P
G
L
V
E
T
-----------------------------------------------------------------------------------------------
41
PsiBlast_CBE
53.94
32%
-35
- C1 -
4QEC
3
?
B:
[2-187]
--
K
K
N
V
L
I
T
G
G
F
K
G
I
G
K
Q
V
A
L
E
F
L
K
----
N
D
----
Y
--
H
V
C
I
T
S
R
Y
F
E
K
E
K
R
I
P
H
L
F
S
S
Y
--
E
-
E
N
I
S
F
Y
Q
L
D
V
T
---
D
E
E
Q
V
N
E
I
I
N
K
I
V
-
K
K
F
G
R
L
D
V
L
V
N
N
A
G
I
S
L
S
D
G
-
L
L
T
E
T
K
T
T
D
F
N
K
M
I
N
T
N
I
L
G
T
Y
F
C
M
K
Y
A
L
K
H
M
Q
K
V
S
C
G
A
I
V
N
I
S
S
I
T
G
L
S
G
F
P
Y
S
I
L
Y
G
S
T
K
H
A
V
I
G
L
T
K
G
A
A
V
E
F
A
D
K
G
I
K
I
N
A
V
A
P
G
I
I
K
T
-----------------------------------------------------------------------------------------------
43
PsiBlast_CBE
53.27
32%
-32
- C1 -
4QED
3
?
B:
[2-187]
--
K
K
N
V
L
I
T
G
G
F
K
G
I
G
K
Q
V
A
L
E
F
L
K
----
N
D
----
Y
--
H
V
C
I
T
S
R
Y
F
E
K
E
K
R
I
P
H
L
F
S
S
Y
--
E
-
E
N
I
S
F
Y
Q
L
D
V
T
---
D
E
E
Q
V
N
E
I
I
N
K
I
V
-
K
K
F
G
R
L
D
V
L
V
N
N
A
G
I
S
L
S
D
G
-
L
L
T
E
T
K
T
T
D
F
N
K
M
I
N
T
N
I
L
G
T
Y
F
C
M
K
Y
A
L
K
H
M
Q
K
V
S
C
G
A
I
V
N
I
S
S
I
T
G
L
S
G
F
P
Y
S
I
L
F
G
S
T
K
H
A
V
I
G
L
T
K
G
A
A
V
E
F
A
D
K
G
I
K
I
N
A
V
A
P
G
I
I
K
T
-----------------------------------------------------------------------------------------------
39
PsiBlast_CBE
53.24
33%
17
- C1 -
3RKU
1
YM71_YEAST
B:
[31-223]
L
A
K
K
T
V
L
I
T
G
A
S
A
G
I
G
K
A
T
A
L
E
-
Y
L
----
E
A
SNGD
M
--
K
L
I
L
A
A
R
R
L
E
K
L
E
E
L
K
K
T
I
D
Q
E
F
P
N
-
A
K
V
H
V
A
Q
L
D
I
T
---
Q
A
E
K
I
K
P
F
-
I
E
N
L
P
Q
E
F
K
D
I
D
I
L
V
N
N
A
G
K
A
L
G
-
S
D
R
V
G
Q
I
A
T
E
D
I
Q
D
V
F
D
T
N
V
T
A
L
I
N
I
T
Q
A
V
L
P
I
F
Q
A
K
N
S
G
D
I
V
N
L
G
S
I
A
G
R
D
A
Y
P
T
G
S
I
Y
C
A
S
K
F
A
V
G
A
F
T
D
S
L
R
K
E
L
I
N
T
K
I
R
V
I
L
I
A
P
G
L
V
E
T
-----------------------------------------------------------------------------------------------
37
PsiBlast_CBE
53.20
33%
17
- C1 -
3RKU
1
YM71_YEAST
D:
[31-223]
L
A
K
K
T
V
L
I
T
G
A
S
A
G
I
G
K
A
T
A
L
E
-
Y
L
----
E
A
SNGD
M
--
K
L
I
L
A
A
R
R
L
E
K
L
E
E
L
K
K
T
I
D
Q
E
F
P
N
-
A
K
V
H
V
A
Q
L
D
I
T
---
Q
A
E
K
I
K
P
F
-
I
E
N
L
P
Q
E
F
K
D
I
D
I
L
V
N
N
A
G
K
A
L
G
-
S
D
R
V
G
Q
I
A
T
E
D
I
Q
D
V
F
D
T
N
V
T
A
L
I
N
I
T
Q
A
V
L
P
I
F
Q
A
K
N
S
G
D
I
V
N
L
G
S
I
A
G
R
D
A
Y
P
T
G
S
I
Y
C
A
S
K
F
A
V
G
A
F
T
D
S
L
R
K
E
L
I
N
T
K
I
R
V
I
L
I
A
P
G
L
V
E
T
-----------------------------------------------------------------------------------------------
84
PsiBlast_CBE
41.91
34%
-14
- C1 -
1HDC
1
HSD_STREX
D:
[3-183]
L
S
G
K
T
V
I
I
T
G
G
A
R
G
L
G
A
E
A
A
R
Q
-
A
V
----
A
A
----
G
AR
V
V
L
A
D
V
L
D
E
E
G
A
A
T
A
R
E
L
G
-------
D
A
A
R
Y
Q
H
L
D
V
T
IEE
D
W
Q
R
V
V
A
Y
---
A
R
-
E
E
F
G
S
V
D
G
L
V
N
N
A
G
I
S
T
G
-
M
-
F
L
E
T
E
S
V
E
R
F
R
K
V
V
E
I
N
L
T
G
V
F
I
G
M
K
T
V
I
P
A
M
K
D
A
G
G
G
S
I
V
N
I
S
S
A
A
G
L
M
G
L
A
L
T
S
S
Y
G
A
S
K
W
G
V
R
G
L
S
K
L
A
A
V
E
L
G
T
D
R
I
R
V
N
S
V
H
P
G
---------------------------------------------------------------------------------------------------