@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu33490: (2016-07-26 )
MRLVKQEYVLDGLDCSNCARKIENGVKGIKGINGCAVNFAASTLTVSADGKEEQWVTNKVEKKVKSIDPHVTVRQKHIKKSADDGYRNRMVNMLIRMAAAVILGAAAYLVQSGTIEFFLFLGAYLIIGGDIIIRAVKNIIRGQVFDEHFLMALATIGAFLIQQYPEGVAVMLFYQIGELFQGAAVSRSRKSISALMDIRPDYANLKTKNGIEQVSSEDVQTGDIIVVNPGESIPLDGKVVQGSAMVDTSALTGESVPRKAAEGQDVMSGFINQNGVLHIEVTKGYQESAVSKILDLVQNASSRKARTENFITKFAKYYTPAVVIIAVLLAFVPPLVLSGAALSDWVYRALIFLVISCPCALVVSIPLGFFGGIGAASKAGVLVKGSNYLEALNQVKYAVFDKTGTLTKGSFEVTEIKPAEGFTKDRLLEAAAYAELHSQHPIAESVRKAYGKMLSSDEIESYEEISGHGIFAKVNGTEILAGNKKLMEREQIEDVPDENAGTIVHVAVDQRYAGAIIIADEIKEDAAQAVADLKSLGIKQTAMLTGDSKQTGEAVGKQLGIGEVYAELLPQDKVAQVEALEAKLLPSEKLIFVGDGINDTPVLARADIGVAMGGLGSDAAVEAADIVLMTDQPSKIAEAIRIAKRTRRIVWQNIGFALGVKAIFLILGAFGIATMWEAVFSDVGVTLLAVANAMRVMRLKNK
Atome Classification :
(20 SA)
.........10........20........30........40........50-........60........70.........80........90.....-..-.100.......110..-..-...--..120..--.....130.......140........150.......160.-------------...-...170-.......180.......190.......200..-.....210.-......-.220.......230.......240.-..--....250.......260.----------..----------....270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410....--------------...420.-------------------.-----.....430..------------..----------------...440...-.-...450..-.-----.---------.-...460...--------------------.---...470---...----.--------.--...480-.......-----------.------.---------------490.----------------------.---------..-----.--..500--......------------------------.------------------------.510----------------------...----------------------------......520.......530.......540.......550.......560-----------------------------------------------------.-----------------------------------------------------..---------....570.......580.......590.......600.......610.......620.......630.......640.......650......----.660.......670------.-------...----------....680-------.........690.......700------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MRL
V
K
Q
E
Y
VLDGL
D
C
S
N
C
A
R
K
I
E
N
G
VKGIKGING
C
A
V
N
F
A
A
S
T
L
T
V
SADGK-E
E
Q
W
V
T
N
K
V
E
K
K
V
K
SIDP
H
-
V
T
V
R
Q
K
H
I
KKSAD
D
G
Y
R
N
R
M
V
N
M
L
I
R
-
M
A
-
A
A
V
I
L
G
A
A
A
Y
L
V--QS-GT-
I
E
F
--
F
L
F
L
G
A
Y
--
L
I
I
G
G
D
I
I
I
R
A
V
K
N
I
IR-GQ
V
F
D
E
H
F
L
M
A
L
A
T
I
G
A
F
L
I
Q
Q-------------YPE-
G
V
A
V
M
L
-
F
Y
Q
I
G
E
L
F
Q
G
A
AVS
R
S
R
K
S
I
S
A
L
M
DIRPDYAN-LKTKN
G
-
I
E
-
Q
VSSED-VQTG
D
I
I
V
VNPGESIPLD
G
K
V
VQG
S
-
A
M
--
V
D
TSALTGESVPRKAAE
G
----------
Q
D
----------
V
M
S
G
F
INQN
G
V
L
H
I
E
VTKG
Y
Q
E
S
A
V
S
K
I
L
D
L
V
QNASSRKA
R
T
E
N
F
I
T
K
F
A
K
YY
T
P
A
V
V
I
I
A
V
L
L
A
FV
P
P
L
VLSG
A
A
L
S
D
W
V
Y
R
A
L
I
F
L
V
ISCP
C
A
L
V
V
SI
P
L
G
F
FGGIGAASK
A
G
V
L
V
KG
S
N
Y
L
E
A
L
N
Q
V
K
Y
A
V
FDKTGTLTKG
S
F
E
V
T
E
I--------------KPAEGF
T
-------------------
K
-----
D
R
L
L
E
A
A
A
Y
A
------------
E
L
----------------HSQH
P
I
A
E
S
-
V
-
R
K
A
Y
-
G
K
M-L-----
S
---------
S
-
D
E
I
E
S
Y
E
E
I--------------------S---G
H
G
I
-
F
---
A
K
V----N--------G--
T
E
I
L---AG
N
K
K
L
M
-----------
E
------
R
---------------
E
Q
I
E----------------------D---------VP-----D--ENA
G
---
T
I
V
H
V
A
------------------------V------------------------DQ------------------------RYA----------------------------
G
A
I
I
I
A
D
E
I
K
E
D
A
A
Q
A
V
A
D
L
K
SLGI
K
Q
T
A
M
LTGDSK
Q
T
G
E
A
V
G
KQL
G
I
G
-----------------------------------------------------
E
-----------------------------------------------------
V
Y
---------
A
E
LLPQ
D
K
V
A
Q
V
E
A
L
E
A
KLLPSE
K
L
I
F
V
GDGINDTP
V
L
A
R
AD
I
G
V
A
MGGLGSDAAV
E
A
A
D
I
V
L
MTDQ
P
S
K
I
A
E
A
I
R
I
A
K
R
T
R
R
I
V
W
Q
NI
G
F
A
L
----
G
V
K
A
I
F
L
I
L
G
A
F
G
-------
I
-------
A
T
M
----------
W
E
A
V
F
---------
S
DV
G
V
T
L
L
A
V
A
N
A
M
R
V
M
RLKNK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
70.53
36%
-11
- C2 -
4UMW
2
?
A:
[124-730]
------------------------------------------------------------------------------------------
R
L
K
E
N
L
-
P
-
L
I
-
T
L
I
V
M
M
A
I
S
W
G
L
--
E
Q
-
F
N
-
H
P
F
G
Q
L
A
F
I
A
T
T
--
L
V
G
L
Y
P
I
A
R
Q
A
L
R
L
I
K
S
-
G
S
Y
F
A
I
E
T
L
M
S
V
A
A
I
G
A
L
F
I
G
A
-------------
T
A
E
-
A
A
M
V
L
L
-
L
F
L
I
G
E
R
L
E
G
W
A
A
S
R
----
V
S
A
L
M
A
L
K
P
E
T
A
T
--
R
L
R
N
G
E
R
E
-
E
V
A
I
N
S
-
L
R
P
G
D
V
I
E
V
A
A
G
G
R
L
P
A
D
G
K
L
L
S
P
F
-
A
S
--
F
D
E
S
A
L
T
G
E
S
I
P
V
E
R
A
T
G
----------
D
K
----------
V
P
A
G
A
T
S
V
D
R
L
V
T
L
E
V
L
S
E
P
G
A
S
A
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D
R
I
L
K
L
I
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E
A
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A
P
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D
R
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Y
T
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A
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A
V
A
L
L
V
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L
V
P
P
L
L
F
A
-
A
S
W
Q
E
W
I
Y
K
G
L
T
L
L
L
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G
C
P
C
A
L
V
I
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A
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T
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G
L
A
A
A
A
R
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L
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D
K
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T
L
T
V
G
K
P
R
V
T
A
I
--------------
H
P
A
T
G
I
S
-------------------
E
-----
S
E
L
L
T
L
A
A
A
V
------------
E
Q
----------------
G
A
T
H
P
L
A
Q
A
I
V
-
R
E
A
Q
-
V
A
E
-
L
-----
A
---------
I
-
P
T
A
E
S
Q
R
A
L
--------------------
V
---
G
S
G
I
-
E
---
A
Q
V
----
N
--------
G
--
E
R
V
L
---
I
C
A
A
G
K
H
-----------
P
------
A
---------------
D
A
F
A
----------------------
G
---------
L
I
-----
N
E
L
E
S
A
G
Q
--
T
V
V
L
V
V
------------------------
R
------------------------
N
D
------------------------
D
V
L
----------------------------
G
I
I
A
L
Q
D
T
L
R
A
D
A
A
T
A
I
S
E
L
N
A
L
G
V
K
G
V
-
I
L
T
G
D
N
P
R
A
A
A
A
I
A
G
E
L
G
L
------------------------------------------------------
E
-----------------------------------------------------
F
K
---------
A
G
L
L
P
E
D
K
V
K
A
V
----
T
K
L
N
Q
H
A
P
L
A
M
V
G
D
G
I
N
D
A
P
A
M
K
A
A
A
I
G
I
A
M
G
S
-
G
T
D
V
A
L
E
T
A
D
A
A
L
T
H
N
H
L
R
G
L
V
Q
M
I
E
L
A
R
A
T
H
A
N
I
R
Q
N
I
T
I
A
L
----
G
L
K
G
I
F
L
V
T
T
L
L
G
-------
M
-------
T
G
L
----------
W
L
A
V
L
---------
A
D
T
G
A
T
V
L
V
T
A
N
A
L
R
L
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
HHSearch
69.74
33%
-17
- C2 -
3J09
-
COPA_ARCFU
A:
[15-731]
--
P
M
E
R
T
V
R
V
T
G
M
T
C
A
M
C
V
K
S
I
E
T
A
V
G
S
L
E
G
V
E
E
V
R
V
N
L
A
T
E
T
A
F
I
R
F
D
E
K
R
I
D
------
F
E
T
I
K
R
V
I
E
D
L
G
Y
G
V
V
D
E
Q
A
A
V
S
A
E
V
E
H
L
S
R
M
K
R
K
L
Y
V
A
A
F
-
A
G
V
L
L
L
F
L
A
H
F
I
SL
P
Y
-
E
D
F
V
Q
L
--
L
I
A
L
P
A
I
--
F
Y
S
G
S
S
I
F
K
A
A
F
S
A
L
R
R
--
R
T
L
N
M
D
V
M
Y
S
M
G
V
G
A
A
F
L
A
S
V
L
STAGVLPREYS-
F
Y
E
T
S
V
L
L
L
A
-
F
L
L
L
G
R
T
L
E
A
R
A
K
S
R
T
G
E
A
I
K
K
L
V
G
L
Q
A
K
T
A
V
-
V
I
R
D
G
K
-
E
I
-
A
V
P
V
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E
-
V
A
V
G
D
I
V
I
V
R
P
G
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K
I
P
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G
V
V
V
E
G
E
-
S
Y
--
V
D
E
S
M
I
S
G
E
P
V
P
V
L
K
S
K
G
----------
D
E
----------
V
F
G
A
T
I
N
N
T
G
V
L
K
I
R
A
T
R
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G
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L
A
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A
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N
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V
A
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V
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F
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G
T
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K
P
E
V
T
D
L
--------------
V
P
L
N
G
-
D
-------------------
E
-----
R
E
L
L
R
L
A
A
I
A
------------
E
R
----------------
R
S
E
H
P
I
A
E
A
-
I
-
V
K
K
A
-
L
E
H
G
I
-----
E
---------
L
-
G
E
P
E
K
V
E
V
I
--------------------
A
---
G
E
G
V
-
V
---
A
------------------
D
G
I
L
---
V
G
N
K
R
L
M
-----------
E
------
D
---------------
F
G
V
A
----------------------
V
S
N
E
V
E
L
A
L
E
K
L
-----
E
--
R
E
A
K
---
T
A
V
I
V
A
------------------------
R
------------------------
N
G
------------------------
R
V
E
----------------------------
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
-
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
D
-----------------------------------------------------
L
-----------------------------------------------------
V
I
---------
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
----
K
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
S
-
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
K
I
K
Q
N
I
F
W
A
L
----
I
Y
N
V
I
L
I
P
A
A
A
G
L
-------
L
Y
P
IFGVV
F
R
P
----------
E
F
A
G
L
---------
A
M
A
M
S
S
V
S
V
V
A
N
S
L
L
L
R
N
Y
V
P
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
69.72
34%
-1
- C2 -
3J09
-
COPA_ARCFU
A:
[24-693]
-----------
G
M
T
C
A
M
C
V
K
S
I
E
T
A
V
G
S
L
E
G
V
E
E
V
R
V
N
L
A
T
E
T
A
F
I
R
F
D
E
K
-
R
I
D
F
E
T
--
I
K
R
V
I
E
D
L
G
Y
G
-
V
V
D
E
Q
A
A
V
--
S
A
E
V
E
H
L
S
R
M
K
R
K
L
Y
V
-
A
A
F
A
G
V
L
L
L
F
L
A
H
F
I
--
S
L
-
P
Y
-
E
D
F
--
V
Q
L
L
I
A
L
P
A
I
F
Y
S
G
S
S
I
F
K
A
A
F
S
A
L
R
-
R
R
T
L
N
M
D
V
M
Y
S
M
G
V
G
A
A
F
L
A
S
V
L
STAGVLPREYSF
Y
E
T
-
S
V
L
L
L
A
-
F
L
L
L
G
R
T
L
E
A
R
A
K
S
R
T
G
E
A
I
K
K
L
V
G
L
Q
A
K
T
A
--
V
V
I
R
D
G
-
K
E
I
A
V
P
V
E
E
-
V
A
V
G
D
I
V
I
V
R
P
G
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K
I
P
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D
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V
V
V
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G
E
-
S
Y
--
V
D
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S
M
I
S
G
E
P
V
P
V
L
K
S
K
G
----------
D
E
----------
V
F
G
A
T
I
N
N
T
G
V
L
K
I
R
A
T
R
V
G
G
E
T
L
L
A
Q
I
V
K
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V
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D
A
M
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P
P
I
Q
R
L
A
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V
V
A
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F
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V
L
L
V
A
I
-
S
A
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W
Y
F
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A
H
A
P
L
L
F
A
F
T
T
L
I
A
V
L
V
V
A
C
P
C
A
F
G
L
A
T
P
T
A
L
T
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G
M
G
K
G
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
D
L
--------------
V
P
L
N
G
D
E
-------------------
R
-----
E
-
L
L
R
L
A
A
I
A
------------
E
R
----------------
R
S
E
H
P
I
A
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A
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V
-
K
K
A
L
-
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H
G
-
I
-----
E
---------
L
-
G
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P
E
K
V
E
V
I
--------------------
A
---
G
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G
V
-
V
---
A
------
D
--------
G
----
I
L
---
V
G
N
K
R
L
M
-----------
E
D
F
G
V
A
V
S
---------------
N
E
V
E
L
A
L
-------------------
E
---------
K
L
-----
E
--
R
E
A
K
---
T
A
V
I
V
A
------------------------
R
------------------------
N
G
------------------------
R
V
E
----------------------------
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
-
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
D
-----------------------------------------------------
L
-----------------------------------------------------
V
I
---------
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
----
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
S
-
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
K
I
K
Q
N
I
F
W
A
L
-----
I
Y
N
V
I
L
I
P
A
A
A
G
-------
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
HHSearch
69.66
35%
-8
- C2 -
4UMW
2
?
A:
[124-730]
-------------------------------------------------------------------------------------------
R
L
K
E
N
L
P
-
L
I
-
T
L
I
V
M
M
A
I
S
W
G
L
E
-
Q
F
N
H
P
-
F
G
Q
--
L
A
F
I
A
T
T
--
L
V
G
L
Y
P
I
A
R
Q
A
L
R
L
I
K
S
-
G
S
Y
F
A
I
E
T
L
M
S
V
A
A
I
G
A
L
F
I
G
A
-------------
T
A
E
-
A
A
M
V
L
L
-
L
F
L
I
G
E
R
L
E
G
W
A
A
S
R
----
V
S
A
L
M
A
L
K
P
E
T
A
T
-
R
L
R
N
G
E
-
R
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-
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V
A
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N
S
-
L
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D
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V
A
A
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G
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K
L
L
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F
-
A
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--
F
D
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A
L
T
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S
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P
V
E
R
A
T
G
----------
D
K
----------
V
P
A
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A
T
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V
D
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L
V
T
L
E
V
L
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P
G
A
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A
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K
L
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A
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A
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M
A
V
A
L
L
V
T
L
V
P
P
L
L
F
A
-
A
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W
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W
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K
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L
T
L
L
L
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C
P
C
A
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A
A
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T
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G
L
A
A
A
A
R
R
G
A
L
I
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G
G
A
A
L
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Q
L
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V
T
Q
V
A
F
D
K
T
G
T
L
T
V
G
K
P
R
V
T
A
I
--------------
H
P
A
T
G
I
S
-------------------
E
-----
S
E
L
L
T
L
A
A
A
V
------------
E
Q
----------------
G
A
T
H
P
L
A
Q
A
-
I
-
V
R
E
A
-
Q
V
A
E
L
-----
A
---------
I
-
P
T
A
E
S
Q
R
A
L
--------------------
V
---
G
S
G
I
-
E
---
A
Q
V
----
N
--------
G
--
E
R
V
L
---
I
C
A
A
G
K
H
-----------
P
------
A
---------------
D
A
F
A
G
L
I
-------------------
N
---------
E
L
-----
E
--
S
A
G
Q
---
T
V
V
L
V
V
------------------------
R
------------------------
N
D
------------------------
D
V
L
----------------------------
G
I
I
A
L
Q
D
T
L
R
A
D
A
A
T
A
I
S
E
L
N
A
L
G
V
K
-
G
V
I
L
T
G
D
N
P
R
A
A
A
A
I
A
G
E
L
G
L
E
-----------------------------------------------------------------------------------------------------------
F
K
---------
A
G
L
L
P
E
D
K
V
K
A
V
T
K
L
N
Q
----
H
A
P
L
A
M
V
G
D
G
I
N
D
A
P
A
M
K
A
A
A
I
G
I
A
M
G
S
-
G
T
D
V
A
L
E
T
A
D
A
A
L
T
H
N
H
L
R
G
L
V
Q
M
I
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L
A
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A
T
H
A
N
I
R
Q
N
I
T
I
A
L
----
G
L
K
G
I
F
L
V
T
T
L
L
G
-------
M
-------
T
G
L
----------
W
L
A
V
L
---------
A
D
T
G
A
T
V
L
V
T
A
N
A
L
R
L
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
Fugue
69.39
37%
-14
- C2 -
4UMW
2
?
A:
[124-730]
------------------------------------------------------------------------------------------
R
L
K
E
N
L
P
L
-
I
T
-
L
I
V
M
M
A
I
S
W
G
L
E
--
Q
F
-
N
H
-
P
F
G
--
Q
L
A
F
I
A
T
--
T
L
V
G
L
Y
P
I
A
R
Q
A
L
R
L
I
K
S
G
S
Y
F
A
I
E
T
L
M
S
V
A
A
I
G
A
L
F
I
G
A
-------------
T
A
E
-
A
A
M
V
L
L
-
L
F
L
I
G
E
R
L
E
G
W
A
A
S
R
----
V
S
A
L
M
A
L
K
P
E
T
A
T
-
R
L
R
N
G
E
-
R
E
-
E
V
A
I
N
S
-
L
R
P
G
D
V
I
E
V
A
A
G
G
R
L
P
A
D
G
K
L
L
S
P
F
-
A
S
--
F
D
E
S
A
L
T
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S
I
P
V
E
R
A
T
G
----------
D
K
----------
V
P
A
G
A
T
S
V
D
R
L
V
T
L
E
V
L
S
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G
A
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A
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R
I
L
K
L
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A
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A
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D
R
F
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T
P
A
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M
A
V
A
L
L
V
T
L
V
P
P
L
L
F
-
A
A
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W
Q
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W
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Y
K
G
L
T
L
L
L
I
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C
P
C
A
L
V
I
S
T
P
A
A
I
T
S
G
L
A
A
A
A
R
R
G
A
L
I
K
G
G
A
A
L
E
Q
L
G
R
V
T
Q
V
A
F
D
K
T
G
T
L
T
V
G
K
P
R
V
T
A
I
--------------
H
P
A
T
G
I
S
-------------------
E
-----
S
E
L
L
T
L
A
A
A
V
------------
E
Q
----------------
G
A
T
H
P
L
A
Q
A
-
I
V
R
E
A
Q
-
V
A
E
-
L
-----
A
---------
I
-
P
T
A
E
S
Q
R
A
L
--------------------
V
---
G
S
G
I
-
E
---
A
Q
V
----
N
--------
G
--
E
R
V
L
I
C
A
A
G
K
H
P
A
D
-----------
A
------
F
---------------
A
G
L
I
----------------------
N
---------
E
L
-----
E
--
S
A
G
Q
---
T
V
V
L
V
V
------------------------
R
------------------------
N
D
------------------------
D
V
L
----------------------------
G
I
I
A
L
Q
D
T
L
R
A
D
A
A
T
A
I
S
E
L
N
A
L
G
V
K
G
V
-
I
L
T
G
D
N
P
R
A
A
A
A
I
A
G
E
L
G
L
------------------------------------------------------
E
-----------------------------------------------------
F
K
---------
A
G
L
L
P
E
D
K
V
K
A
V
T
K
L
N
Q
H
----
A
P
L
A
M
V
G
D
G
I
N
D
A
P
A
M
K
A
A
A
I
G
I
A
M
G
S
-
G
T
D
V
A
L
E
T
A
D
A
A
L
T
H
N
H
L
R
G
L
V
Q
M
I
E
L
A
R
A
T
H
A
N
I
R
Q
N
I
T
I
A
L
----
G
L
K
G
I
F
L
V
T
T
L
L
G
-------
M
-------
T
G
L
----------
W
L
A
V
L
---------
A
D
T
G
A
T
V
L
V
T
A
N
A
L
R
L
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
65.52
36%
-13
- C2 -
4UMV
2
?
A:
[126-730]
--------------------------------------------------------------------------------------------
K
E
N
L
-
P
-
L
I
-
T
L
I
V
M
M
A
I
S
W
G
L
--
E
Q
-
F
N
-
H
P
F
G
Q
L
A
F
I
A
T
T
--
L
V
G
L
Y
P
I
A
R
Q
A
L
R
L
I
K
S
-
G
S
Y
F
A
I
E
T
L
M
S
V
A
A
I
G
A
L
F
I
G
A
-------------
T
A
E
-
A
A
M
V
L
L
-
L
F
L
I
G
E
R
L
E
G
W
A
A
S
R
A
R
Q
G
V
S
A
L
M
A
L
K
P
E
T
A
T
--
R
L
R
N
G
E
R
E
-
E
V
A
I
N
S
-
L
R
P
G
D
V
I
E
V
A
A
G
G
R
L
P
A
D
G
K
L
L
S
P
F
-
A
S
--
F
D
E
S
A
L
T
G
E
S
I
P
V
E
R
A
T
G
----------
D
K
----------
V
P
A
G
A
T
S
V
D
R
L
V
T
L
E
V
L
S
E
P
G
A
S
A
I
D
R
I
L
K
L
I
E
E
A
E
E
R
R
A
P
I
E
R
F
I
D
R
F
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R
I
Y
T
P
A
I
M
A
V
A
L
L
V
T
L
V
P
P
L
L
F
A
-
A
S
W
Q
E
W
I
Y
K
G
L
T
L
L
L
I
G
C
P
C
A
L
V
I
S
T
P
A
A
I
T
S
G
L
A
A
A
A
R
R
G
A
L
I
K
G
G
A
A
L
E
Q
L
G
R
V
T
Q
V
A
F
D
K
T
G
T
L
T
V
G
K
P
R
V
T
A
I
--------------
H
P
A
T
G
I
S
-------------------
E
-----
S
E
L
L
T
L
A
A
A
V
------------
E
Q
----------------
G
A
T
H
P
L
A
Q
A
I
V
-
R
E
A
Q
-
V
A
E
-
L
-----
A
---------
I
-
P
T
A
E
S
Q
R
A
L
--------------------
V
---
G
S
G
I
-
E
---
A
Q
V
----
N
--------
G
--
E
R
V
L
---
I
C
A
A
G
K
H
-----------
P
------
A
---------------
D
A
F
A
----------------------
G
---------
L
I
-----
N
E
L
E
S
A
G
Q
--
T
V
V
L
V
V
------------------------
R
------------------------
N
D
------------------------
D
V
L
----------------------------
G
I
I
A
L
Q
D
T
L
R
A
D
A
A
T
A
I
S
E
L
N
A
L
G
V
K
G
V
-
I
L
T
G
D
N
P
R
A
A
A
A
I
A
G
E
L
G
L
------------------------------------------------------
E
-----------------------------------------------------
F
K
---------
A
G
L
L
P
E
D
K
V
K
A
V
----
T
K
L
N
Q
H
A
P
L
A
M
V
G
D
G
I
N
D
A
P
A
M
K
A
A
A
I
G
I
A
M
G
S
-
G
T
D
V
A
L
E
T
A
D
A
A
L
T
H
N
H
L
R
G
L
V
Q
M
I
E
L
A
R
A
T
H
A
N
I
R
Q
N
I
T
I
A
L
----
G
L
K
G
I
F
L
V
T
T
L
L
G
-------
M
-------
T
G
L
----------
W
L
A
V
L
---------
A
D
T
G
A
T
V
L
V
T
A
N
A
L
R
L
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
Fugue
64.16
28%
-38
- C2 -
3RFU
3
?
A:
[74-736]
------------------------------------------
V
S
P
E
Y
L
D
M
R
-
R
R
F
W
I
A
L
M
L
T
I
P
V
V
I
L
E
M
G
-
G
H
G
L
K
H
F
I
S
G
N
G
S
S
W
I
Q
L
L
L
A
T
P
V
V
L
-
W
G
-
G
W
P
F
F
K
R
G
W
Q
S
L
--
K
T
-
G
Q
-
L
N
M
--
F
T
L
I
A
M
G
--
I
G
V
A
W
I
Y
S
M
V
A
V
L
--------
W
P
G
V
F
P
H
A
F
R
S
Q
E
G
V
V
A
V
Y
-------------
F
E
A
-
A
A
V
I
T
T
-
L
V
L
L
G
Q
V
L
E
L
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A
R
E
Q
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S
A
I
R
A
L
L
K
L
V
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A
H
-
R
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E
D
G
-
S
E
-
E
E
V
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L
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N
V
A
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D
L
L
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E
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I
P
V
D
G
E
V
Q
E
G
R
-
S
F
--
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
E
A
S
----------
A
K
----------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
V
A
V
L
S
F
I
V
W
A
L
L
G
P
Q
P
A
L
S
Y
G
L
I
A
A
V
S
V
L
I
I
A
C
P
C
A
L
G
L
A
T
P
M
S
I
M
V
G
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
P
K
L
T
R
I
--------------
V
T
-
D
D
F
V
-------------------
E
-----
D
N
A
L
A
L
A
A
A
L
------------
E
H
----------------
Q
S
E
H
P
L
A
N
A
-
I
-
V
H
A
A
K
E
K
G
-
L
-----
S
---------
L
-
G
S
V
E
A
F
E
A
P
--------------------
T
---
G
K
G
V
-
V
---
G
Q
V
----
D
--------
G
--
H
H
V
A
---
I
G
N
A
R
L
M
-----------
Q
------
E
H
G
G
D
N
----------
A
P
L
F
----------------------
E
---------
K
A
-----
D
--
E
L
R
G
K
GA
S
V
M
F
M
A
------------------------
V
------------------------
D
G
------------------------
K
T
V
----------------------------
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
-
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
K
-----------------------------------------------------
K
-----------------------------------------------------
V
V
---------
A
E
I
M
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
---
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
G
T
-
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
----
I
Y
N
V
L
G
V
P
L
A
A
G
V
-------
L
YPLT---
G
L
L
----------
L
S
P
M
I
---------
A
A
A
A
M
A
L
S
S
V
S
V
I
I
N
A
L
R
L
K
R
V
TL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
HHSearch
58.85
20%
-
- C2 -
3IXZ
-
ATP4A_PIG
A:
[140-798]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
-
A
L
A
L
I
A
-
V
V
V
V
T
G
C
F
G
Y
Y
Q
E
F
K
S
T
N
I
I
A
S
F
K
N
L
V
P
Q
Q
A
T
-
V
I
R
D
G
D
-
K
F
-
Q
I
N
A
D
Q
-
L
V
V
G
D
L
V
E
M
K
G
G
D
R
V
P
A
D
I
R
I
L
Q
A
Q
G
R
K
--
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
E
C
T
H
ESPLETR
N
I
----------
A
F
F
S
T
M
C
L
E
G
T
A
Q
G
L
V
V
N
T
G
D
R
T
I
I
G
R
I
A
S
L
A
S
G
V
E
N
E
K
T
P
I
A
I
E
I
E
H
F
V
D
I
I
A
G
L
A
I
L
F
G
A
T
F
F
I
V
A
M
C
I
G
--
Y
T
F
L
R
A
M
V
F
F
M
A
I
V
V
A
Y
V
P
E
G
L
L
A
T
V
T
V
C
L
S
L
T
A
K
R
L
A
S
K
N
C
V
V
K
N
L
E
A
V
E
T
L
G
S
T
S
V
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
S
H
L
--------------
W
F
D
N
H
I
H
S
A
DTTEDQSGQTFDQSS
E
T
W
-----
R
A
L
C
R
V
L
T
L
C
------------
N
R
A
A
F
K
S
GQDAVPVPK
R
I
V
I
G
D
A
S
E
T
A
-
L
-
L
K
F
S
-
E
L
T
L
G
-----
N
A
M
G
Y
-----
R
-
E
R
F
P
K
V
C
E
I
--------------------
P
FNS
T
N
K
F
-
Q
L
S
I
H
T
L
EDPR
D
--------
P
R
H
V
L
V
M
---
K
G
A
P
E
R
V
-----------
L
------
E
---------------
R
C
S
S
I
L
I
KGQE
L
P
L
D
E
Q
W
R
E
A
F
Q
T
A
Y
L
---------
S
L
-----
G
--
G
L
G
E
---
R
V
L
G
F
C
------------------------
Q
L
Y
L
S
EKDYPPGYAFDVEAMNFPTS
G
L
------------------------
S
F
A
----------------------------
G
L
V
S
M
I
D
P
P
R
A
T
V
P
D
A
V
L
K
C
R
T
A
G
I
R
-
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
A
S
V
G
I
I
SEGS
E
T
V
E
D
I
A
ARLRVPVDQVNRKDAR
A
C
V
I
N
G
M
Q
L
K
D
MD
P
S
E
L
V
E
A
L
R
THPE
M
-----------------------------------------------------
V
F
---------
A
R
T
S
P
Q
Q
K
L
V
I
V
E
S
C
Q
R
---
L
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
I
G
V
A
M
G
I
A
G
S
D
A
A
K
N
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
Q
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
----
T
K
N
I
P
E
L
T
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
HHSearch
57.46
35%
24
- C2 -
3J08
-
COPA_ARCFU
A:
[127-731]
--------------------------------------------------------------------------------------------------------------------------
V
Q
L
--
L
I
A
L
P
A
I
--
F
Y
S
G
S
S
I
F
K
A
A
F
S
A
L
R
R
--
R
T
L
N
M
D
V
M
Y
S
M
G
V
G
A
A
F
L
A
S
V
L
S
T
A
GVLPREYS-
F
Y
E
T
S
V
L
L
L
A
-
F
L
L
L
G
R
T
L
E
A
R
A
K
S
R
T
G
E
A
I
K
K
L
V
G
L
Q
A
K
T
A
V
-
V
I
R
D
G
K
-
E
I
-
A
V
P
V
E
E
-
V
A
V
G
D
I
V
I
V
R
P
G
E
K
I
P
V
D
G
V
V
V
E
G
E
-
S
Y
--
V
D
E
S
M
I
S
G
E
P
V
P
V
L
K
S
K
G
----------
D
E
----------
V
F
G
A
T
I
N
N
T
G
V
L
K
I
R
A
T
R
V
G
G
E
T
L
L
A
Q
I
V
K
L
V
E
D
A
M
G
S
K
P
P
I
Q
R
L
A
D
K
V
V
A
Y
F
I
P
T
V
L
L
V
A
I
S
A
F
I
Y
W
Y
F
I
A
H
-
A
P
L
L
F
A
F
T
T
L
I
A
V
L
V
V
A
C
P
C
A
F
G
L
A
T
P
T
A
L
T
V
G
M
G
K
G
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
D
L
--------------
V
P
L
N
G
-
D
-------------------
E
-----
R
E
L
L
R
L
A
A
I
A
------------
E
R
----------------
R
S
E
H
P
I
A
E
A
-
I
-
V
K
K
A
-
L
E
H
G
I
-----
E
---------
L
-
G
E
P
E
K
V
E
V
I
--------------------
A
---
G
E
G
V
-
V
---
A
------------------
D
G
I
L
---
V
G
N
K
R
L
M
-----------
E
------
D
---------------
F
G
V
A
----------------------
V
S
N
E
V
E
L
A
L
E
K
L
-----
E
--
R
E
A
K
---
T
A
V
I
V
A
------------------------
R
------------------------
N
G
------------------------
R
V
E
----------------------------
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
-
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
D
-----------------------------------------------------
L
-----------------------------------------------------
V
I
---------
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
----
K
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
S
-
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
K
I
K
Q
N
I
F
W
A
L
----
I
Y
N
V
I
L
I
P
A
A
A
G
L
L
Y
P
IFGV
V
-------
F
R
P
----------
E
F
A
G
L
---------
A
M
A
M
S
S
V
S
V
V
A
N
S
L
L
L
R
N
Y
V
P
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
55.88
38%
26
- C2 -
3J08
-
COPA_ARCFU
A:
[201-693]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
T
L
E
A
R
A
K
S
R
T
G
E
A
I
K
K
L
V
G
L
Q
A
K
T
A
--
V
V
I
R
D
G
-
K
E
I
A
V
P
V
E
E
-
V
A
V
G
D
I
V
I
V
R
P
G
E
K
I
P
V
D
G
V
V
V
E
G
E
-
S
Y
--
V
D
E
S
M
I
S
G
E
P
V
P
V
L
K
S
K
G
----------
D
E
----------
V
F
G
A
T
I
N
N
T
G
V
L
K
I
R
A
T
R
V
G
G
E
T
L
L
A
Q
I
V
K
L
V
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D
A
M
G
S
K
P
P
I
Q
R
L
A
D
K
V
V
A
Y
F
I
P
T
V
L
L
V
A
I
-
S
A
F
I
Y
W
Y
F
I
A
H
A
P
L
L
F
A
F
T
T
L
I
A
V
L
V
V
A
C
P
C
A
F
G
L
A
T
P
T
A
L
T
V
G
M
G
K
G
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
D
L
--------------
V
P
L
N
G
D
E
-------------------
R
-----
E
-
L
L
R
L
A
A
I
A
------------
E
R
----------------
R
S
E
H
P
I
A
E
A
I
V
-
K
K
A
L
-
E
H
G
-
I
-----
E
---------
L
-
G
E
P
E
K
V
E
V
I
--------------------
A
---
G
E
G
V
-
V
---
A
------
D
--------
G
----
I
L
---
V
G
N
K
R
L
M
-----------
E
D
F
G
V
A
V
S
---------------
N
E
V
E
L
A
L
-------------------
E
---------
K
L
-----
E
--
R
E
A
K
---
T
A
V
I
V
A
------------------------
R
------------------------
N
G
------------------------
R
V
E
----------------------------
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
-
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
D
-----------------------------------------------------
L
-----------------------------------------------------
V
I
---------
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
----
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
S
-
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
K
I
K
Q
N
I
F
W
A
L
-----
I
Y
N
V
I
L
I
P
A
A
A
G
-------
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
55.09
34%
30
- C2 -
3RFU
3
?
D:
[187-692]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
F
E
-
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
S
A
H
R
I
K
E
D
G
S
-
E
E
-
E
V
S
L
D
N
-
V
A
V
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
G
E
V
Q
E
G
R
-
S
F
--
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
E
A
S
----------
A
K
----------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
V
A
V
L
S
F
I
V
W
A
L
L
G
P
Q
P
A
L
S
Y
G
L
I
A
A
V
S
V
L
I
I
A
C
P
C
A
L
G
L
A
T
P
M
S
I
M
V
G
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
P
K
L
T
R
I
--------------
V
-
T
D
D
F
V
-------------------
E
-----
D
N
A
L
A
L
A
A
A
L
------------
E
H
----------------
Q
S
E
H
P
L
A
N
A
I
V
-
H
A
A
K
-
E
K
G
-
L
-----
S
---------
L
-
G
S
V
E
A
F
E
A
P
--------------------
T
---
G
K
G
V
-
V
---
G
Q
V
----
D
--------
G
--
H
H
V
A
---
I
G
N
A
R
L
M
-----------
Q
------
E
---------------
H
G
G
D
----------------------
N
---------
A
P
LFEKA
D
--
E
L
R
G
KGA
S
V
M
F
M
A
------------------------
V
------------------------
D
G
------------------------
K
T
V
----------------------------
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
-
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
K
-----------------------------------------------------
K
-----------------------------------------------------
V
V
---------
A
E
I
M
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
---
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
-
G
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
--------
I
Y
N
V
L
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
55.05
34%
29
- C2 -
3RFU
3
?
A:
[187-692]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
F
E
-
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
S
A
H
R
I
K
E
D
G
S
-
E
E
-
E
V
S
L
D
N
-
V
A
V
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
G
E
V
Q
E
G
R
-
S
F
--
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
E
A
S
----------
A
K
----------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
V
A
V
L
S
F
I
V
W
A
L
L
G
P
Q
P
A
L
S
Y
G
L
I
A
A
V
S
V
L
I
I
A
C
P
C
A
L
G
L
A
T
P
M
S
I
M
V
G
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
P
K
L
T
R
I
--------------
V
-
T
D
D
F
V
-------------------
E
-----
D
N
A
L
A
L
A
A
A
L
------------
E
H
----------------
Q
S
E
H
P
L
A
N
A
I
V
-
H
A
A
K
-
E
K
G
-
L
-----
S
---------
L
-
G
S
V
E
A
F
E
A
P
--------------------
T
---
G
K
G
V
-
V
---
G
Q
V
----
D
--------
G
--
H
H
V
A
---
I
G
N
A
R
L
M
-----------
Q
------
E
---------------
H
G
G
D
----------------------
N
---------
A
P
L
F
E
K
A
D
--
E
L
R
G
K
GA
S
V
M
F
M
A
------------------------
V
------------------------
D
G
------------------------
K
T
V
----------------------------
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
-
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
K
-----------------------------------------------------
K
-----------------------------------------------------
V
V
---------
A
E
I
M
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
---
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
-
G
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
--------
I
Y
N
V
L
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
54.92
34%
31
- C2 -
4BYG
3
?
A:
[187-692]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
F
E
-
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
S
A
H
R
I
K
E
D
G
S
-
E
E
-
E
V
S
L
D
N
-
V
A
V
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
G
E
V
Q
E
G
R
-
S
F
--
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
E
A
S
----------
A
K
----------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
V
A
V
L
S
F
I
V
W
A
L
L
G
P
Q
P
A
L
S
Y
G
L
I
A
A
V
S
V
L
I
I
A
C
P
C
A
L
G
L
A
T
P
M
S
I
M
V
G
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
P
K
L
T
R
I
--------------
V
-
T
D
D
F
V
-------------------
E
-----
D
N
A
L
A
L
A
A
A
L
------------
E
H
----------------
Q
S
E
H
P
L
A
N
A
I
V
-
H
A
A
K
-
E
K
G
-
L
-----
S
---------
L
-
G
S
V
E
A
F
E
A
P
--------------------
T
---
G
K
G
V
-
V
---
G
Q
V
----
D
--------
G
--
H
H
V
A
---
I
G
N
A
R
L
M
-----------
Q
------
E
---------------
H
G
G
D
----------------------
N
---------
A
P
L
F
E
K
A
D
--
E
L
R
G
K
G
A
S
V
M
F
M
A
------------------------
V
------------------------
D
G
------------------------
K
T
V
----------------------------
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
-
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
K
-----------------------------------------------------
K
-----------------------------------------------------
V
V
---------
A
E
I
M
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
---
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
-
G
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
--------
I
Y
N
V
L
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
54.86
34%
29
- C2 -
3RFU
3
?
B:
[187-692]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
F
E
-
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
S
A
H
R
I
K
E
D
G
S
-
E
E
-
E
V
S
L
D
N
-
V
A
V
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
G
E
V
Q
E
G
R
-
S
F
--
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
E
A
S
----------
A
K
----------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
V
A
V
L
S
F
I
V
W
A
L
L
G
P
Q
P
A
L
S
Y
G
L
I
A
A
V
S
V
L
I
I
A
C
P
C
A
L
G
L
A
T
P
M
S
I
M
V
G
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
P
K
L
T
R
I
--------------
V
-
T
D
D
F
V
-------------------
E
-----
D
N
A
L
A
L
A
A
A
L
------------
E
H
----------------
Q
S
E
H
P
L
A
N
A
I
V
-
H
A
A
K
-
E
K
G
-
L
-----
S
---------
L
-
G
S
V
E
A
F
E
A
P
--------------------
T
---
G
K
G
V
-
V
---
G
Q
V
----
D
--------
G
--
H
H
V
A
---
I
G
N
A
R
L
M
-----------
Q
------
E
---------------
H
G
G
D
----------------------
N
---------
A
P
LFEKA
D
--
E
L
R
G
KGA
S
V
M
F
M
A
------------------------
V
------------------------
D
G
------------------------
K
T
V
----------------------------
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
-
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
K
-----------------------------------------------------
K
-----------------------------------------------------
V
V
---------
A
E
I
M
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
---
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
-
G
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
--------
I
Y
N
V
L
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
54.75
34%
35
- C2 -
4BEV
2
?
A:
[187-692]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
F
E
-
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
S
A
H
R
I
K
E
D
G
S
-
E
E
-
E
V
S
L
D
N
-
V
A
V
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
G
E
V
Q
E
G
R
-
S
F
--
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
E
A
S
----------
A
K
----------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
V
A
V
L
S
F
I
V
W
A
L
L
G
P
Q
P
A
L
S
Y
G
L
I
A
A
V
S
V
L
I
I
A
C
P
C
A
L
G
L
A
T
P
M
S
I
M
V
G
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
P
K
L
T
R
I
--------------
V
-
T
D
D
F
V
-------------------
E
-----
D
N
A
L
A
L
A
A
A
L
------------
E
H
----------------
Q
S
E
H
P
L
A
N
A
I
V
-
H
A
A
K
-
E
K
G
-
L
-----
S
---------
L
-
G
S
V
E
A
F
E
A
P
--------------------
T
---
G
K
G
V
-
V
---
G
Q
V
----
D
--------
G
--
H
H
V
A
---
I
G
N
A
R
L
M
-----------
Q
------
E
---------------
H
G
G
D
----------------------
N
---------
A
P
L
F
E
K
A
D
--
E
L
R
G
K
G
A
S
V
M
F
M
A
------------------------
V
------------------------
D
G
------------------------
K
T
V
----------------------------
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
-
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
K
-----------------------------------------------------
K
-----------------------------------------------------
V
V
---------
A
E
I
M
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
---
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
-
G
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
--------
I
Y
N
V
L
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
54.59
34%
30
- C2 -
3RFU
3
?
C:
[187-692]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
F
E
-
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
S
A
H
R
I
K
E
D
G
S
-
E
E
-
E
V
S
L
D
N
-
V
A
V
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
G
E
V
Q
E
G
R
-
S
F
--
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
E
A
S
----------
A
K
----------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
V
A
V
L
S
F
I
V
W
A
L
L
G
P
Q
P
A
L
S
Y
G
L
I
A
A
V
S
V
L
I
I
A
C
P
C
A
L
G
L
A
T
P
M
S
I
M
V
G
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
P
K
L
T
R
I
--------------
V
-
T
D
D
F
V
-------------------
E
-----
D
N
A
L
A
L
A
A
A
L
------------
E
H
----------------
Q
S
E
H
P
L
A
N
A
I
V
-
H
A
A
K
-
E
K
G
-
L
-----
S
---------
L
-
G
S
V
E
A
F
E
A
P
--------------------
T
---
G
K
G
V
-
V
---
G
Q
V
----
D
--------
G
--
H
H
V
A
---
I
G
N
A
R
L
M
-----------
Q
------
E
---------------
H
G
G
D
----------------------
N
---------
A
P
LFEKA
D
--
E
L
R
G
KGA
S
V
M
F
M
A
------------------------
V
------------------------
D
G
------------------------
K
T
V
----------------------------
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
-
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
K
-----------------------------------------------------
K
-----------------------------------------------------
V
V
---------
A
E
I
M
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
---
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
-
G
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
--------
I
Y
N
V
L
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
Fugue
51.89
21%
-20
- C2 -
3B8E
6
AT1A1_PIG
A:
[1-998]
------------------
A
K
K
E
R
D
M
D
E
L
K
K
E
V
S
M
D
D
H
K
L
S
L
D
E
L
H
R
K
Y
G
T
D
-
L
S
R
G
L
T
P
A
R
A
A
E
I
L
A
R
D
G
P
-
N
A
L
T
P
P
P
T
T
P
E
W
V
K
F
C
R
Q
L
F
G
G
F
S
M
L
-
L
W
-
I
G
A
I
L
C
F
L
A
Y
G
I
--
Q
A
-
A
T
--------------------------
E
E
E
P
Q
N
-
D
N
L
Y
L
G
V
V
L
S
A
V
V
I
I
T
G
C
F
S
Y
Y
-------------
Q
E
----------------------
A
K
S
S
K
I
M
E
S
F
K
N
M
V
P
Q
Q
A
L
-
V
I
R
N
G
E
-
K
M
-
S
I
N
A
E
E
-
V
V
V
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
A
N
G
C
K
--
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
D
----------
F
T
N
ENPLETRNI
A
F
F
S
T
N
C
V
E
G
T
A
R
G
I
V
V
Y
T
G
D
R
T
V
M
G
R
I
A
T
L
A
S
G
L
E
G
G
Q
T
P
I
A
A
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
I
L
S
--
L
I
L
E
Y
T
W
L
E
A
V
I
F
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
H
M
WSDN
Q
I
H
E
A
DTTEN
Q
S
G
V
S
F
D
-------------------
K
TS
A
T
W
L
A
L
S
R
I
A
G
L
C
NR
A
V
F
Q
A
NQENL
P
I
----------------
L
K
R
A
V
A
G
D
A
-
S
-
E
S
A
L
-
L
K
C
-
I
-----
E
L
CCGS
V
K
E
M
R
-
E
R
Y
T
K
I
V
E
I
PFNSTN
K
Y
Q
L
S
I
H
K
N
PNTAE
P
---
R
H
L
L
-
V
---
M
K
G
----
A
--------
P
--
E
R
I
L
---
D
R
C
S
S
I
L
I
HGKEQPLDEE
L
------
K
---------------
D
A
F
Q
----------------------
N
---------
A
Y
-----
L
--
E
L
G
G
L
G
E
R
V
L
G
F
C
------------------------
H
------------------------
L
F
L
P
DEQFPEGF
Q
F
D
T
DDVNFPLDN
L
C
F
V
----------------------------
G
L
I
S
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
-
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
I
-----------------------------------------------------
S
EGN
E
T
V
E
D
IAARLNIPVSQVNPRDAK
A
C
V
V
H
G
S
D
L
K
D
MT
S
E
Q
L
D
D
I
L
K
YHTEI
V
F
---------
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
---
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
S
K
K
A
D
I
G
V
A
M
G
I
A
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
TS
N
I
P
E
I
T
P
F
L
I
F
I
I
A
N
-------
I
-------
P
L
P
----------
L
G
T
V
T
I
L
C
I
DLGTD
M
V
P
A
I
S
L
A
Y
E
Q
A
E
S
D
I
M
K
R
Q
P
R
NPKTDKLVN
E
Q
L
I
S
M
A
YGQ
I
G
M
I
Q
A
L
G
G
F
F
T
Y
F
V
I
L
A
E
N
GFLPIHLL
G
L
R
V
N
WDDRWINDVEDSYG
Q
Q
W
T
Y
EQRKIVEFT
C
H
T
P
F
F
V
T
I
V
V
V
Q
W
A
D
L
V
I
C
KTRRNSVFQQGMKN
K
I
L
I
F
G
L
F
E
E
T
A
L
A
A
F
L
S
Y
CPGMGVA
L
R
M
Y
P
LKPTWWFCAFPY
S
L
L
I
F
V
Y
D
E
V
R
K
L
I
I
R
R
RPGGW
V
E
K
E
T
YY
80
HHSearch
48.06
22%
-5
- C2 -
2ZXE
5
?
A:
[137-794]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
G
V
V
L
S
T
-
V
V
I
V
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
R
I
M
D
S
F
K
N
M
V
P
Q
Q
A
L
-
V
I
R
D
G
E
-
K
S
-
T
I
N
A
E
F
-
V
V
A
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
A
H
G
C
K
--
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
E
FSSENPLETR
N
I
----------
A
F
F
S
T
N
C
V
E
G
T
A
R
G
V
V
V
Y
T
G
D
R
T
V
M
G
R
I
A
T
L
A
S
G
L
E
V
G
R
T
P
I
A
I
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
I
L
S
L
I
L
G
--
Y
S
W
L
E
A
V
I
F
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
H
M
--------------
W
F
D
N
Q
I
H
E
A
DTTENQSGAAFDKTS
A
T
W
-----
S
A
L
S
R
I
A
A
L
C
------------
N
R
A
V
F
Q
A
GQDNVPILKRS
V
A
G
D
A
S
E
S
A
-
L
-
L
K
C
I
-
E
L
C
C
G
-----
S
V
Q
G
------
M
R
D
R
N
P
K
I
V
E
I
--------------------
P
FNS
T
N
K
Y
Q
L
---
S
I
H
----
E
NEKSSES
R
Y
--
L
L
V
M
---
K
G
A
P
E
R
I
-----------
L
------
D
---------------
R
C
S
T
ILLNG
A
E
E
P
LK
E
D
M
K
E
A
F
Q
N
A
Y
L
---------
E
L
-----
G
--
G
L
G
E
---
R
V
L
G
F
C
H
F
ALPEDKYNEG
Y
P
F
D
ADEPNFPT
T
------------------------
D
L
------------------------
C
F
V
----------------------------
G
L
M
A
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
-
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
I
-----------------------------------------------------
S
EGNET
I
E
D
I
A
A
R
L
NIPIGQVNPRDAK
A
C
V
V
H
G
S
D
L
K
D
LS
T
E
V
L
D
D
I
L
H
Y
H
T
E
I
V
F
---------
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
---
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
I
G
V
A
M
G
I
S
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
----
T
S
N
I
P
E
I
T
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
44.60
23%
-4
- C2 -
1MHS
-
PMA1_NEUCR
A:
[188-741]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
-
E
I
E
A
P
E
-
V
V
P
G
D
I
L
Q
V
E
E
G
T
I
I
P
A
D
G
R
I
V
T
D
D
-
A
F
L
Q
V
D
Q
S
A
L
T
G
E
S
L
A
V
D
K
H
K
G
----------
D
Q
----------
V
F
A
S
S
A
V
K
R
G
E
A
F
V
V
I
T
A
T
G
D
N
T
F
V
G
R
A
A
A
L
V
N
A
A
S
G
G
S
G
H
F
T
E
V
L
N
G
I
G
T
I
L
L
-
I
L
V
I
F
T
L
L
I
V
W
V
S
S
F
Y
R
S
N
P
I
V
Q
I
L
E
F
-
T
L
A
I
T
I
I
G
V
P
V
G
L
P
A
V
V
T
T
T
M
A
V
G
A
A
Y
L
A
K
K
K
A
I
V
Q
K
L
S
A
I
E
S
L
A
G
V
E
I
L
C
S
D
K
T
G
T
L
T
K
N
K
L
S
L
H
D
P
--------------
Y
T
V
A
G
V
D
-------------------
P
-----
E
D
L
M
L
T
A
C
L
A
------------
A
S
----------------
R
K
K
K
G
I
-
D
A
-
I
-
D
K
A
F
-
L
K
S
-
L
K
Y
Y
PR
A
---------
K
-
S
V
L
S
K
Y
K
V
L
--------------------
Q
---
F
H
P
--
F
---
D
P
V
----
S
--------
K
--
K
V
V
A
---
V
V
E
S
P
Q
G
-----------
E
------
R
I
T
C
V
K
G
A
P
L
F
V
L
K
TV
E
E
D
H
----------------------
P
---------
I
P
-----
E
--
E
------------------------------------
V
------------------------
D
Q
------------------------
A
Y
K
N
K
V
A
E
F
A
T
R
G
F
R
S
L
G
V
A
R
K
RGEG
S
W
E
I
L
G
I
M
P
C
M
D
P
P
R
H
D
T
Y
K
T
V
C
E
A
K
T
L
G
L
-
S
I
K
M
L
T
G
D
A
V
G
I
A
R
E
T
S
R
Q
L
G
L
G
TNIYNAERLGLGGGGDMPGS---------------------------------
E
-----------------------------------------------------
V
Y
D
F
V
E
AADGF
A
E
V
F
P
Q
H
K
Y
N
V
V
E
I
L
Q
Q
R
---
G
Y
L
V
A
M
T
G
D
G
V
N
D
A
P
S
L
K
K
A
D
T
G
I
A
V
E
G
-
S
S
D
A
A
R
S
A
A
D
I
V
F
L
A
P
G
L
G
A
I
I
D
A
L
K
T
S
R
Q
I
F
H
R
M
Y
A
Y
V
V
Y
R
I
----
A
L
S
I
H
L
E
I
F
L
G
L
W
-------
I
-------
A
I
L
N
R
S
L
N
I
E
L
V
V
F
I
A
I
F
---------
A
D
V
A
T
L
A
I
A
Y
D
N
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
HHSearch
43.58
43%
14
- C2 -
3A1C
2
?
A:
[14-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
D
L
--------------
V
P
L
N
G
-
D
-------------------
E
-----
R
E
L
L
R
L
A
A
I
A
------------
E
R
----------------
R
S
E
H
P
I
A
E
A
-
I
-
V
K
K
A
-
L
E
H
G
I
-----
E
---------
L
-
G
E
P
E
K
V
E
V
I
--------------------
A
---
G
E
G
V
-
V
---
A
------------------
D
G
I
L
---
V
G
N
K
R
L
M
-----------
E
------
D
---------------
F
G
V
A
----------------------
V
S
N
E
V
E
L
A
L
E
K
L
-----
E
--
R
E
A
K
---
T
A
V
I
V
A
------------------------
R
------------------------
N
G
------------------------
R
V
E
----------------------------
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
-
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
D
-----------------------------------------------------
L
-----------------------------------------------------
V
I
---------
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
----
K
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
S
-
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------