@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu33940: (2016-07-27 )
MAVKVGINGFGRIGRNVFRAALNNPEVEVVAVNDLTDANMLAHLLQYDSVHGKLDAEVSVDGNNLVVNGKTIEVSAERDPAKLSWGKQGVEIVVESTGFFTKRADAAKHLEAGAKKVIISAPANEEDITIVMGVNEDKYDAANHDVISNASCTTNCLAPFAKVLNDKFGIKRGMMTTVHSYTNDQQILDLPHKDYRRARAAAENIIPTSTGAAKAVSLVLPELKGKLNGGAMRVPTPNVSLVDLVAELNQEVTAEEVNAALKEAAEGDLKGILGYSEEPLVSGDYNGNKNSSTIDALSTMVMEGSMVKVISWYDNESGYSNRVVDLAAYIAKKGL
Atome Classification :
(45 SA)
.........10........20.--.--.---.--....30...-.-....40........50......-..60.-.......70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.--.......200.......210.......220.......230.......240.......250...-.....260....-------.-------..270.......280.......290.......300.......310.......320.......330...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
A
V
K
V
GI
N
G
F
G
R
I
G
R
N
V
F
R
A
AL--N--N---P--
E
V
E
V
V
A
VND-L-T
D
A
N
M
L
A
H
L
L
Q
Y
DSVHGKL
D
A
E
-
V
S
VDG-
N
N
L
V
V
NG
K
T
I
E
V
SAERDPAKLSWGKQ
G
V
E
I
V
V
ESTGFFTKR
A
D
A
A
K
H
L
EAGA
K
K
V
I
I
SAPANEE
D
I
T
I
V
M
GVNEDKYDAANHDVISNASC
T
T
N
C
L
A
P
F
A
K
V
L
N
D
K
FGIKR
G
M
M
T
T
V
HSYTN
D
Q
Q
I
LDL
P
-
H
--
K
D
Y
R
R
A
R
A
A
AENIIPTSTGA
A
K
A
V
S
L
V
L
P
E
L
KGKLNG
G
A
M
RVPTPN
V
S
L
V
D
L
V
A
E
L
N
Q
E-V
T
A
-
E
E
V
N
A
A
L
K
E
AAE-------G-------D
L
K
G
ILGYSEEP
L
V
SGDYNGNKNS
S
T
I
D
A
L
S
T
M
V
MEG
S
M
V
K
V
I
S
W
YDNESGYSN
R
V
V
D
L
A
A
Y
I
A
KKGL
29
PsiBlast_CBE
96.36
84%
-88
- C2 -
1GD1
4
G3P_GEOSE
P:
[1-334]
-
A
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
A
A
L
--
K
--
N
---
P
--
D
I
E
V
V
A
V
N
D
-
L
-
T
D
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
D
A
E
-
V
S
V
N
G
-
N
N
L
V
V
N
G
K
E
I
I
V
K
A
E
R
D
P
E
N
L
A
W
G
E
I
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
L
E
A
G
A
K
K
V
I
I
S
A
P
A
K
N
E
D
I
T
I
V
M
G
V
N
Q
D
K
Y
D
P
K
A
H
H
V
I
S
N
A
S
C
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
L
P
-
H
--
K
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
E
K
E
-
V
T
V
-
E
E
V
N
A
A
L
K
A
A
A
E
-------
G
-------
E
L
K
G
I
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
D
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
G
L
33
PsiBlast_CBE
96.19
83%
-85
- C2 -
1NPT
3
G3P_GEOSE
R:
[1-334]
-
A
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
A
A
L
--
K
--
N
---
P
--
D
I
E
V
V
A
V
N
D
-
L
-
T
D
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
D
A
E
-
V
S
V
N
G
-
N
N
L
V
V
N
G
K
E
I
I
V
K
A
E
R
D
P
E
N
L
A
W
G
E
I
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
L
E
A
G
A
K
K
V
I
I
S
A
P
A
K
N
E
D
I
T
I
V
M
G
V
N
Q
D
K
Y
D
P
K
A
H
H
V
I
S
N
A
S
A
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
L
P
-
H
--
K
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
E
K
E
-
V
T
V
-
E
E
V
N
A
A
L
K
A
A
A
E
-------
G
-------
E
L
K
G
I
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
D
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
G
L
2
PsiBlast_PDB
96.09
84%
-86
- C2 -
2GD1
2
G3P_GEOSE
O:
[1-334]
-
A
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
A
A
L
--
K
--
N
---
P
--
D
I
E
V
V
A
V
N
D
-
L
-
T
D
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
D
A
E
-
V
S
V
N
G
-
N
N
L
V
V
N
G
K
E
I
I
V
K
A
E
R
D
P
E
N
L
A
W
G
E
I
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
L
E
A
G
A
K
K
V
I
I
S
A
P
A
K
N
E
D
I
T
I
V
M
G
V
N
Q
D
K
Y
D
P
K
A
H
H
V
I
S
N
A
S
C
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
L
P
-
H
--
K
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
E
K
E
-
V
T
V
-
E
E
V
N
A
A
L
K
A
A
A
E
-------
G
-------
E
L
K
G
I
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
D
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
G
L
32
PsiBlast_CBE
95.88
83%
-81
- C2 -
1NQA
3
G3P_GEOSE
P:
[1-334]
-
A
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
A
A
L
--
K
--
N
---
P
--
D
I
E
V
V
A
V
N
D
-
L
-
T
D
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
D
A
E
-
V
S
V
N
G
-
N
N
L
V
V
N
G
K
E
I
I
V
K
A
E
R
D
P
E
N
L
A
W
G
E
I
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
L
E
A
G
A
K
K
V
I
I
S
A
P
A
K
N
E
D
I
T
I
V
M
G
V
N
Q
D
K
Y
D
P
K
A
H
H
V
I
S
N
A
S
A
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
L
P
-
H
--
K
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
E
K
E
-
V
T
V
-
E
E
V
N
A
A
L
K
A
A
A
E
-------
G
-------
E
L
K
G
I
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
D
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
G
L
9
PsiBlast_PDB
95.79
83%
-90
- C2 -
2DBV
4
G3P_GEOSE
O:
[1-334]
-
A
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
A
A
L
--
K
--
N
---
P
--
D
I
E
V
V
A
V
N
G
-
L
-
T
D
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
D
A
E
-
V
S
V
N
G
-
N
N
L
V
V
N
G
K
E
I
I
V
K
A
E
R
D
P
E
N
L
A
W
G
E
I
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
L
E
A
G
A
K
K
V
I
I
S
A
P
A
K
N
E
D
I
T
I
V
M
G
V
N
Q
D
K
Y
D
P
K
A
H
H
V
I
S
N
A
S
C
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
A
S
-
H
--
K
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
E
K
E
-
V
T
V
-
E
E
V
N
A
A
L
K
A
A
A
E
-------
G
-------
E
L
K
G
I
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
D
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
G
L
24
PsiBlast_CBE
95.67
84%
-84
- C2 -
2GD1
2
G3P_GEOSE
R:
[1-334]
-
A
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
A
A
L
--
K
--
N
---
P
--
D
I
E
V
V
A
V
N
D
-
L
-
T
D
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
D
A
E
-
V
S
V
N
G
-
N
N
L
V
V
N
G
K
E
I
I
V
K
A
E
R
D
P
E
N
L
A
W
G
E
I
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
L
E
A
G
A
K
K
V
I
I
S
A
P
A
K
N
E
D
I
T
I
V
M
G
V
N
Q
D
K
Y
D
P
K
A
H
H
V
I
S
N
A
S
C
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
L
P
-
H
--
K
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
E
K
E
-
V
T
V
-
E
E
V
N
A
A
L
K
A
A
A
E
-------
G
-------
E
L
K
G
I
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
D
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
G
L
21
PsiBlast_CBE
95.63
84%
-84
- C2 -
3CMC
15
G3P_GEOSE
R:
[1-334]
-
A
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
A
A
L
--
K
--
N
---
P
--
D
I
E
V
V
A
V
N
D
-
L
-
T
D
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
D
A
E
-
V
S
V
N
G
-
N
N
L
V
V
N
G
K
E
I
I
V
K
A
E
R
D
P
E
N
L
A
W
G
E
I
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
L
E
A
G
A
K
K
V
I
I
S
A
P
A
K
N
E
D
I
T
I
V
M
G
V
N
Q
D
K
Y
D
P
K
A
H
H
V
I
S
N
A
S
C
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
L
P
-
H
--
K
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
E
K
E
-
V
T
V
-
E
E
V
N
A
A
L
K
A
A
A
E
-------
G
-------
E
L
K
G
I
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
D
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
G
L
28
PsiBlast_CBE
95.52
84%
-85
- C2 -
1GD1
4
G3P_GEOSE
Q:
[1-334]
-
A
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
A
A
L
--
K
--
N
---
P
--
D
I
E
V
V
A
V
N
D
-
L
-
T
D
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
D
A
E
-
V
S
V
N
G
-
N
N
L
V
V
N
G
K
E
I
I
V
K
A
E
R
D
P
E
N
L
A
W
G
E
I
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
L
E
A
G
A
K
K
V
I
I
S
A
P
A
K
N
E
D
I
T
I
V
M
G
V
N
Q
D
K
Y
D
P
K
A
H
H
V
I
S
N
A
S
C
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
L
P
-
H
--
K
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
E
K
E
-
V
T
V
-
E
E
V
N
A
A
L
K
A
A
A
E
-------
G
-------
E
L
K
G
I
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
D
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
G
L
25
PsiBlast_CBE
95.49
84%
-82
- C2 -
2GD1
2
G3P_GEOSE
Q:
[1-334]
-
A
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
A
A
L
--
K
--
N
---
P
--
D
I
E
V
V
A
V
N
D
-
L
-
T
D
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
D
A
E
-
V
S
V
N
G
-
N
N
L
V
V
N
G
K
E
I
I
V
K
A
E
R
D
P
E
N
L
A
W
G
E
I
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
L
E
A
G
A
K
K
V
I
I
S
A
P
A
K
N
E
D
I
T
I
V
M
G
V
N
Q
D
K
Y
D
P
K
A
H
H
V
I
S
N
A
S
C
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
L
P
-
H
--
K
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
E
K
E
-
V
T
V
-
E
E
V
N
A
A
L
K
A
A
A
E
-------
G
-------
E
L
K
G
I
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
D
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
G
L
1
PsiBlast_PDB
95.49
84%
-85
- C2 -
1GD1
4
G3P_GEOSE
O:
[1-334]
-
A
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
A
A
L
--
K
--
N
---
P
--
D
I
E
V
V
A
V
N
D
-
L
-
T
D
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
D
A
E
-
V
S
V
N
G
-
N
N
L
V
V
N
G
K
E
I
I
V
K
A
E
R
D
P
E
N
L
A
W
G
E
I
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
L
E
A
G
A
K
K
V
I
I
S
A
P
A
K
N
E
D
I
T
I
V
M
G
V
N
Q
D
K
Y
D
P
K
A
H
H
V
I
S
N
A
S
C
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
L
P
-
H
--
K
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
E
K
E
-
V
T
V
-
E
E
V
N
A
A
L
K
A
A
A
E
-------
G
-------
E
L
K
G
I
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
D
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
G
L
23
PsiBlast_CBE
95.44
84%
-83
- C2 -
3CMC
4
G3P_GEOSE
P:
[1-334]
-
A
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
A
A
L
--
K
--
N
---
P
--
D
I
E
V
V
A
V
N
D
-
L
-
T
D
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
D
A
E
-
V
S
V
N
G
-
N
N
L
V
V
N
G
K
E
I
I
V
K
A
E
R
D
P
E
N
L
A
W
G
E
I
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
L
E
A
G
A
K
K
V
I
I
S
A
P
A
K
N
E
D
I
T
I
V
M
G
V
N
Q
D
K
Y
D
P
K
A
H
H
V
I
S
N
A
S
C
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
L
P
-
H
--
K
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
E
K
E
-
V
T
V
-
E
E
V
N
A
A
L
K
A
A
A
E
-------
G
-------
E
L
K
G
I
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
D
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
G
L
43
PsiBlast_CBE
95.38
83%
-89
- C2 -
2DBV
4
G3P_GEOSE
Q:
[1-334]
-
A
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
A
A
L
--
K
--
N
---
P
--
D
I
E
V
V
A
V
N
G
-
L
-
T
D
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
D
A
E
-
V
S
V
N
G
-
N
N
L
V
V
N
G
K
E
I
I
V
K
A
E
R
D
P
E
N
L
A
W
G
E
I
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
L
E
A
G
A
K
K
V
I
I
S
A
P
A
K
N
E
D
I
T
I
V
M
G
V
N
Q
D
K
Y
D
P
K
A
H
H
V
I
S
N
A
S
C
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
A
S
-
H
--
K
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
E
K
E
-
V
T
V
-
E
E
V
N
A
A
L
K
A
A
A
E
-------
G
-------
E
L
K
G
I
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
D
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
G
L
8
PsiBlast_PDB
95.38
83%
-88
- C2 -
1DBV
3
G3P_GEOSE
O:
[1-334]
-
A
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
A
A
L
--
K
--
N
---
P
--
D
I
E
V
V
A
V
N
G
-
L
-
T
D
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
D
A
E
-
V
S
V
N
G
-
N
N
L
V
V
N
G
K
E
I
I
V
K
A
E
R
D
P
E
N
L
A
W
G
E
I
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
L
E
A
G
A
K
K
V
I
I
S
A
P
A
K
N
E
D
I
T
I
V
M
G
V
N
Q
D
K
Y
D
P
K
A
H
H
V
I
S
N
A
S
C
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
A
S
-
H
--
K
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
E
K
E
-
V
T
V
-
E
E
V
N
A
A
L
K
A
A
A
E
-------
G
-------
E
L
K
G
I
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
D
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
G
L
4
PsiBlast_PDB
95.29
83%
-83
- C2 -
1NPT
3
G3P_GEOSE
O:
[1-334]
-
A
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
A
A
L
--
K
--
N
---
P
--
D
I
E
V
V
A
V
N
D
-
L
-
T
D
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
D
A
E
-
V
S
V
N
G
-
N
N
L
V
V
N
G
K
E
I
I
V
K
A
E
R
D
P
E
N
L
A
W
G
E
I
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
L
E
A
G
A
K
K
V
I
I
S
A
P
A
K
N
E
D
I
T
I
V
M
G
V
N
Q
D
K
Y
D
P
K
A
H
H
V
I
S
N
A
S
A
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
L
P
-
H
--
K
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
E
K
E
-
V
T
V
-
E
E
V
N
A
A
L
K
A
A
A
E
-------
G
-------
E
L
K
G
I
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
D
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
G
L
53
PsiBlast_CBE
95.27
82%
-85
- C2 -
3DBV
3
G3P_GEOSE
P:
[1-334]
-
A
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
A
A
L
--
K
--
N
---
P
--
D
I
E
V
V
A
V
N
D
-
T
-
G
G
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
D
A
E
-
V
S
V
N
G
-
N
N
L
V
V
N
G
K
E
I
I
V
K
A
E
R
D
P
E
N
L
A
W
G
E
I
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
L
E
A
G
A
K
K
V
I
I
S
A
P
A
K
N
E
D
I
T
I
V
M
G
V
N
Q
D
K
Y
D
P
K
A
H
H
V
I
S
N
A
S
C
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
A
S
-
H
--
K
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
E
K
E
-
V
T
V
-
E
E
V
N
A
A
L
K
A
A
A
E
-------
G
-------
E
L
K
G
I
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
D
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
G
L
30
PsiBlast_CBE
95.24
83%
-84
- C2 -
1NQA
3
G3P_GEOSE
R:
[1-334]
-
A
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
A
A
L
--
K
--
N
---
P
--
D
I
E
V
V
A
V
N
D
-
L
-
T
D
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
D
A
E
-
V
S
V
N
G
-
N
N
L
V
V
N
G
K
E
I
I
V
K
A
E
R
D
P
E
N
L
A
W
G
E
I
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
L
E
A
G
A
K
K
V
I
I
S
A
P
A
K
N
E
D
I
T
I
V
M
G
V
N
Q
D
K
Y
D
P
K
A
H
H
V
I
S
N
A
S
A
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
L
P
-
H
--
K
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
E
K
E
-
V
T
V
-
E
E
V
N
A
A
L
K
A
A
A
E
-------
G
-------
E
L
K
G
I
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
D
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
G
L
45
PsiBlast_CBE
95.20
83%
-85
- C2 -
1DBV
3
G3P_GEOSE
R:
[1-334]
-
A
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
A
A
L
--
K
--
N
---
P
--
D
I
E
V
V
A
V
N
G
-
L
-
T
D
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
D
A
E
-
V
S
V
N
G
-
N
N
L
V
V
N
G
K
E
I
I
V
K
A
E
R
D
P
E
N
L
A
W
G
E
I
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
L
E
A
G
A
K
K
V
I
I
S
A
P
A
K
N
E
D
I
T
I
V
M
G
V
N
Q
D
K
Y
D
P
K
A
H
H
V
I
S
N
A
S
C
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
A
S
-
H
--
K
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
E
K
E
-
V
T
V
-
E
E
V
N
A
A
L
K
A
A
A
E
-------
G
-------
E
L
K
G
I
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
D
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
G
L
5
PsiBlast_PDB
95.18
83%
-83
- C2 -
1NQA
3
G3P_GEOSE
O:
[1-334]
-
A
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
A
A
L
--
K
--
N
---
P
--
D
I
E
V
V
A
V
N
D
-
L
-
T
D
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
D
A
E
-
V
S
V
N
G
-
N
N
L
V
V
N
G
K
E
I
I
V
K
A
E
R
D
P
E
N
L
A
W
G
E
I
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
L
E
A
G
A
K
K
V
I
I
S
A
P
A
K
N
E
D
I
T
I
V
M
G
V
N
Q
D
K
Y
D
P
K
A
H
H
V
I
S
N
A
S
A
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
L
P
-
H
--
K
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
E
K
E
-
V
T
V
-
E
E
V
N
A
A
L
K
A
A
A
E
-------
G
-------
E
L
K
G
I
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
D
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
G
L
26
PsiBlast_CBE
95.17
84%
-85
- C2 -
2GD1
2
G3P_GEOSE
P:
[1-334]
-
A
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
A
A
L
--
K
--
N
---
P
--
D
I
E
V
V
A
V
N
D
-
L
-
T
D
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
D
A
E
-
V
S
V
N
G
-
N
N
L
V
V
N
G
K
E
I
I
V
K
A
E
R
D
P
E
N
L
A
W
G
E
I
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
L
E
A
G
A
K
K
V
I
I
S
A
P
A
K
N
E
D
I
T
I
V
M
G
V
N
Q
D
K
Y
D
P
K
A
H
H
V
I
S
N
A
S
C
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
L
P
-
H
--
K
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
E
K
E
-
V
T
V
-
E
E
V
N
A
A
L
K
A
A
A
E
-------
G
-------
E
L
K
G
I
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
D
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
G
L
128
HHSearch
95.13
84%
-83
- C2 -
3CMC
14
G3P_GEOSE
O:
[1-334]
-
A
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
A
A
L
--
K
--
N
---
P
--
D
I
E
V
V
A
V
N
D
-
L
-
T
D
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
D
A
E
-
V
S
V
N
G
-
N
N
L
V
V
N
G
K
E
I
I
V
K
A
E
R
D
P
E
N
L
A
W
G
E
I
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
L
E
A
G
A
K
K
V
I
I
S
A
P
A
K
N
E
D
I
T
I
V
M
G
V
N
Q
D
K
Y
D
P
K
A
H
H
V
I
S
N
A
S
C
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
L
P
-
H
--
K
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
E
K
E
-
V
T
V
-
E
E
V
N
A
A
L
K
A
A
A
E
-------
G
-------
E
L
K
G
I
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
D
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
G
L
76
PsiBlast_CBE
78.42
60%
-83
- C2 -
1VC2
1
?
A:
[1-331]
--
M
K
V
G
I
N
G
F
G
R
I
G
R
Q
V
F
R
I
-
L
--
H
--
E
---
R
--
G
V
E
V
A
L
I
N
D
-
L
-
T
D
N
K
T
L
A
H
L
L
K
Y
D
S
T
Y
G
R
F
P
G
A
-
V
G
Y
D
E
-
E
N
L
Y
V
D
G
K
A
I
R
A
T
A
I
K
D
P
R
E
I
P
W
K
Q
A
G
V
G
V
V
V
E
S
T
G
V
F
T
D
G
E
K
A
R
A
H
L
E
A
G
A
K
K
V
I
I
T
A
P
A
K
N
E
D
I
T
V
V
L
G
V
N
H
E
Q
Y
D
P
A
K
H
H
I
L
S
N
A
S
C
T
T
N
S
L
A
P
V
M
K
V
L
E
K
A
F
G
V
E
K
A
L
M
T
T
V
H
S
Y
T
N
D
Q
R
L
L
D
L
P
-
H
--
K
D
L
R
R
A
R
A
A
A
L
N
I
I
P
T
T
T
G
A
A
K
A
T
A
L
V
L
P
S
L
K
G
R
F
D
G
M
A
L
R
V
P
T
P
T
G
S
I
S
D
I
T
A
L
L
K
R
E
-
V
T
A
-
E
E
V
N
A
A
L
K
A
A
A
E
-------
G
-------
P
L
K
G
I
L
A
Y
T
E
D
E
I
V
L
R
D
I
V
M
D
P
H
S
S
I
V
D
G
K
L
T
K
A
I
-
G
N
L
V
K
V
F
A
W
Y
D
N
E
W
G
Y
A
N
R
V
A
D
L
V
E
L
V
L
K
K
G
V
13
PsiBlast_PDB
72.78
56%
-60
- C2 -
2EP7
1
G3P_AQUAE
A:
[3-340]
--
I
K
V
G
I
N
G
F
G
R
I
G
R
S
F
F
R
A
S
W
--
G
--
R
---
E
--
E
I
E
I
V
A
I
N
D
-
L
-
T
D
A
K
H
L
A
H
L
L
K
Y
D
S
V
H
G
I
F
K
G
S
-
V
E
A
K
D
-
D
S
I
V
V
D
G
K
E
I
K
V
F
A
Q
K
D
P
S
Q
I
P
W
G
D
L
G
V
D
V
V
I
E
A
T
G
V
F
R
D
R
E
N
A
S
K
H
L
Q
G
G
A
K
K
V
I
I
T
A
P
A
K
N
P
D
I
T
V
V
L
G
V
N
E
E
K
Y
N
P
K
E
H
N
I
I
S
N
A
S
C
T
T
N
C
L
A
P
C
V
K
V
L
N
E
A
F
G
V
E
K
G
Y
M
V
T
V
H
A
Y
T
N
D
Q
R
L
L
D
L
P
-
H
--
K
D
F
R
R
A
R
A
A
A
I
N
I
V
P
T
T
T
G
A
A
K
A
I
G
E
V
I
P
E
L
K
G
K
L
D
G
T
A
R
R
V
P
V
P
D
G
S
L
I
D
L
T
V
V
V
N
K
A
-
P
S
S
V
E
E
V
N
E
K
F
R
E
A
A
Q
-------
K
Y
R
E
SGKV
Y
L
K
E
I
L
Q
Y
C
E
D
P
I
V
S
T
D
I
V
G
N
P
H
S
A
I
F
D
A
P
L
T
Q
V
I
D
-
N
L
V
H
I
A
A
W
Y
D
N
E
W
G
Y
S
C
R
L
R
D
L
V
I
Y
L
A
E
R
--
61
PsiBlast_CBE
72.75
56%
-41
- C2 -
1DC6
1
G3P1_ECOLI
B:
[2-330]
--
I
K
V
G
I
N
G
F
G
R
I
G
R
I
V
F
R
A
A
Q
--
K
--
R
---
S
--
D
I
E
I
V
A
I
N
D
-
L
-
L
D
A
D
Y
M
A
Y
M
L
K
Y
D
S
T
H
G
R
F
D
G
T
-
V
E
V
K
D
-
G
H
L
I
V
N
G
K
K
I
R
V
T
A
E
R
D
P
A
N
L
K
W
D
E
V
G
V
D
V
V
A
E
A
T
G
L
F
L
T
D
E
T
A
R
K
H
I
T
A
G
A
K
K
V
V
M
T
G
P
S
K
D
N
T
P
M
F
V
K
G
A
N
F
D
K
Y
--
A
G
Q
D
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
N
D
N
F
G
I
I
E
G
L
M
T
T
V
H
A
T
T
A
T
Q
K
T
V
D
G
P
S
H
--
K
D
W
R
G
G
R
G
A
S
Q
N
I
I
P
S
S
T
G
A
A
K
A
V
G
K
V
L
P
E
L
N
G
K
L
T
G
M
A
F
R
V
P
T
P
N
V
S
V
V
D
L
T
V
R
L
E
K
A
-
A
T
Y
-
E
Q
I
K
A
A
V
K
A
A
A
E
-------
G
-------
E
M
K
G
V
L
G
Y
T
E
D
D
V
V
S
T
D
F
N
G
E
V
C
T
S
V
F
D
A
K
A
G
I
A
L
N
D
N
F
V
K
L
V
S
W
Y
D
N
E
T
G
Y
S
N
K
V
L
D
L
I
A
H
I
S
K
---
17
PsiBlast_PDB
72.73
56%
-42
- C2 -
1GAD
1
G3P1_ECOLI
O:
[2-330]
--
I
K
V
G
I
N
G
F
G
R
I
G
R
I
V
F
R
A
A
Q
--
K
--
R
---
S
--
D
I
E
I
V
A
I
N
D
-
L
-
L
D
A
D
Y
M
A
Y
M
L
K
Y
D
S
T
H
G
R
F
D
G
T
-
V
E
V
K
D
-
G
H
L
I
V
N
G
K
K
I
R
V
T
A
E
R
D
P
A
N
L
K
W
D
E
V
G
V
D
V
V
A
E
A
T
G
L
F
L
T
D
E
T
A
R
K
H
I
T
A
G
A
K
K
V
V
M
T
G
P
S
K
D
N
T
P
M
F
V
K
G
A
N
F
D
K
Y
--
A
G
Q
D
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
N
D
N
F
G
I
I
E
G
L
M
T
T
V
H
A
T
T
A
T
Q
K
T
V
D
G
P
S
H
--
K
D
W
R
G
G
R
G
A
S
Q
N
I
I
P
S
S
T
G
A
A
K
A
V
G
K
V
L
P
E
L
N
G
K
L
T
G
M
A
F
R
V
P
T
P
N
V
S
V
V
D
L
T
V
R
L
E
K
A
-
A
T
Y
-
E
Q
I
K
A
A
V
K
A
A
A
E
-------
G
-------
E
M
K
G
V
L
G
Y
T
E
D
D
V
V
S
T
D
F
N
G
E
V
C
T
S
V
F
D
A
K
A
G
I
A
L
N
D
N
F
V
K
L
V
S
W
Y
D
N
E
T
G
Y
S
N
K
V
L
D
L
I
A
H
I
S
K
---
124
HHSearch
72.62
58%
-58
- C2 -
2EP7
1
G3P_AQUAE
A:
[3-340]
--
I
K
V
G
I
N
G
F
G
R
I
G
R
S
F
F
R
A
S
W
--
G
--
R
---
E
--
E
I
E
I
V
A
I
N
D
-
L
-
T
D
A
K
H
L
A
H
L
L
K
Y
D
S
V
H
G
I
F
K
G
S
-
V
E
A
K
D
-
D
S
I
V
V
D
G
K
E
I
K
V
F
A
Q
K
D
P
S
Q
I
P
W
G
D
L
G
V
D
V
V
I
E
A
T
G
V
F
R
D
R
E
N
A
S
K
H
L
Q
G
G
A
K
K
V
I
I
T
A
P
A
K
N
P
D
I
T
V
V
L
G
V
N
E
E
K
Y
N
P
K
E
H
N
I
I
S
N
A
S
C
T
T
N
C
L
A
P
C
V
K
V
L
N
E
A
F
G
V
E
K
G
Y
M
V
T
V
H
A
Y
T
N
D
Q
R
L
L
D
L
P
-
H
--
K
D
F
R
R
A
R
A
A
A
I
N
I
V
P
T
T
T
G
A
A
K
A
I
G
E
V
I
P
E
L
K
G
K
L
D
G
T
A
R
R
V
P
V
P
D
G
S
L
I
D
L
T
V
V
V
N
K
A
P
S
S
V
-
E
E
V
N
E
K
F
R
E
A
A
Q
K
Y
R
E
SGK
V
-------
Y
L
K
E
I
L
Q
Y
C
E
D
P
I
V
S
T
D
I
V
G
N
P
H
S
A
I
F
D
A
P
L
T
Q
V
-
I
D
N
L
V
H
I
A
A
W
Y
D
N
E
W
G
Y
S
C
R
L
R
D
L
V
I
Y
L
A
E
R
--
63
PsiBlast_CBE
72.17
55%
-43
- C2 -
1GAE
1
G3P1_ECOLI
O:
[2-330]
--
I
K
V
G
I
N
G
F
G
R
I
G
R
I
V
F
R
A
A
Q
--
K
--
R
---
S
--
D
I
E
I
V
A
I
N
D
-
L
-
L
D
A
D
Y
M
A
Y
M
L
K
Y
D
S
T
H
G
R
F
D
G
T
-
V
E
V
K
D
-
G
H
L
I
V
N
G
K
K
I
R
V
T
A
E
R
D
P
A
N
L
K
W
D
E
V
G
V
D
V
V
A
E
A
T
G
L
F
L
T
D
E
T
A
R
K
H
I
T
A
G
A
K
K
V
V
M
T
G
P
S
K
D
N
T
P
M
F
V
K
G
A
N
F
D
K
Y
--
A
G
Q
D
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
N
D
N
F
G
I
I
E
G
L
M
T
T
V
H
A
T
T
A
T
Q
K
T
V
D
G
P
S
H
--
K
D
W
R
G
G
R
G
A
S
Q
N
I
I
P
S
S
T
G
A
A
K
A
V
G
K
V
L
P
E
L
N
G
K
L
T
G
M
A
F
R
V
P
T
P
N
V
S
V
V
D
L
T
V
R
L
E
K
A
-
A
T
Y
-
E
Q
I
K
A
A
V
K
A
A
A
E
-------
G
-------
E
M
K
G
V
L
G
Y
T
E
D
D
V
V
S
T
D
F
N
G
E
V
C
T
S
V
F
D
A
K
A
G
I
A
L
N
D
N
F
V
K
L
V
S
W
Y
D
T
E
T
G
Y
S
N
K
V
L
D
L
I
A
H
I
S
K
---
55
PsiBlast_CBE
72.17
56%
-60
- C2 -
2EP7
1
G3P_AQUAE
B:
[2-340]
-
A
I
K
V
G
I
N
G
F
G
R
I
G
R
S
F
F
R
A
S
W
--
G
--
R
---
E
--
E
I
E
I
V
A
I
N
D
-
L
-
T
D
A
K
H
L
A
H
L
L
K
Y
D
S
V
H
G
I
F
K
G
S
-
V
E
A
K
D
-
D
S
I
V
V
D
G
K
E
I
K
V
F
A
Q
K
D
P
S
Q
I
P
W
G
D
L
G
V
D
V
V
I
E
A
T
G
V
F
R
D
R
E
N
A
S
K
H
L
Q
G
G
A
K
K
V
I
I
T
A
P
A
K
N
P
D
I
T
V
V
L
G
V
N
E
E
K
Y
N
P
K
E
H
N
I
I
S
N
A
S
C
T
T
N
C
L
A
P
C
V
K
V
L
N
E
A
F
G
V
E
K
G
Y
M
V
T
V
H
A
Y
T
N
D
Q
R
L
L
D
L
P
-
H
--
K
D
F
R
R
A
R
A
A
A
I
N
I
V
P
T
T
T
G
A
A
K
A
I
G
E
V
I
P
E
L
K
G
K
L
D
G
T
A
R
R
V
P
V
P
D
G
S
L
I
D
L
T
V
V
V
N
K
A
-
P
S
S
V
E
E
V
N
E
K
F
R
E
A
A
Q
-------
K
Y
R
E
SGKV
Y
L
K
E
I
L
Q
Y
C
E
D
P
I
V
S
T
D
I
V
G
N
P
H
S
A
I
F
D
A
P
L
T
Q
V
I
D
-
N
L
V
H
I
A
A
W
Y
D
N
E
W
G
Y
S
C
R
L
R
D
L
V
I
Y
L
A
E
R
--
122
HHSearch
72.05
53%
-47
- C2 -
4LSM
5
?
A:
[16-346]
-
T
I
K
I
G
I
N
G
F
G
R
I
G
R
M
V
F
R
A
A
Q
--
H
--
R
---
N
--
D
I
E
I
V
G
I
N
D
-
L
-
L
D
A
D
Y
M
A
Y
M
L
K
Y
D
S
T
H
G
R
Y
G
G
M
-
V
E
V
R
E
-
G
A
L
V
V
N
G
K
K
I
R
V
T
S
E
R
D
P
A
N
L
K
W
N
E
V
G
A
V
V
V
V
E
S
T
G
L
F
L
T
D
E
T
A
R
K
H
I
Q
A
G
A
K
K
V
V
M
T
G
P
P
K
D
D
T
P
M
F
V
M
G
V
N
N
T
M
Y
K
G
--
Q
E
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
I
I
H
E
K
F
G
I
V
E
G
L
M
T
T
V
H
A
T
T
A
T
Q
K
T
V
D
G
P
-
S
Q-
K
D
W
R
G
G
R
G
A
A
Q
N
I
I
P
S
A
T
G
A
A
K
A
V
G
K
V
I
P
A
L
N
G
R
L
T
G
M
A
F
R
V
P
T
P
N
V
S
V
V
D
L
T
A
R
L
E
R
P
-
A
T
Y
-
E
Q
I
C
A
A
I
K
A
A
S
E
-------
G
-------
E
L
K
G
I
L
G
Y
T
E
D
E
V
V
S
T
D
M
N
G
V
A
L
T
S
V
F
D
V
K
A
G
I
S
L
N
D
R
F
V
K
L
I
S
W
Y
D
N
E
T
G
Y
S
H
K
V
L
D
L
V
A
Y
I
S
A
H
--
60
PsiBlast_CBE
71.22
56%
-41
- C2 -
1GAD
1
G3P1_ECOLI
P:
[2-330]
--
I
K
V
G
I
N
G
F
G
R
I
G
R
I
V
F
R
A
A
Q
--
K
--
R
---
S
--
D
I
E
I
V
A
I
N
D
-
L
-
L
D
A
D
Y
M
A
Y
M
L
K
Y
D
S
T
H
G
R
F
D
G
T
-
V
E
V
K
D
-
G
H
L
I
V
N
G
K
K
I
R
V
T
A
E
R
D
P
A
N
L
K
W
D
E
V
G
V
D
V
V
A
E
A
T
G
L
F
L
T
D
E
T
A
R
K
H
I
T
A
G
A
K
K
V
V
M
T
G
P
S
K
D
N
T
P
M
F
V
K
G
A
N
F
D
K
Y
--
A
G
Q
D
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
N
D
N
F
G
I
I
E
G
L
M
T
T
V
H
A
T
T
A
T
Q
K
T
V
D
G
P
S
H
--
K
D
W
R
G
G
R
G
A
S
Q
N
I
I
P
S
S
T
G
A
A
K
A
V
G
K
V
L
P
E
L
N
G
K
L
T
G
M
A
F
R
V
P
T
P
N
V
S
V
V
D
L
T
V
R
L
E
K
A
-
A
T
Y
-
E
Q
I
K
A
A
V
K
A
A
A
E
-------
G
-------
E
M
K
G
V
L
G
Y
T
E
D
D
V
V
S
T
D
F
N
G
E
V
C
T
S
V
F
D
A
K
A
G
I
A
L
N
D
N
F
V
K
L
V
S
W
Y
D
N
E
T
G
Y
S
N
K
V
L
D
L
I
A
H
I
S
K
---
15
PsiBlast_PDB
71.13
56%
-36
- C2 -
1S7C
6
G3P1_ECOLI
A:
[2-331]
-
T
I
K
V
G
I
N
G
F
G
R
I
G
R
I
V
F
R
A
A
Q
--
K
--
R
---
S
--
D
I
E
I
V
A
I
N
D
-
L
-
L
D
A
D
Y
M
A
Y
M
L
K
Y
D
S
T
H
G
R
F
D
G
T
-
V
E
V
K
D
-
G
H
L
I
V
N
G
K
K
I
R
V
T
A
E
R
D
P
A
N
L
K
W
D
E
V
G
V
D
V
V
A
E
A
T
G
L
F
L
T
D
E
T
A
R
K
H
I
T
A
G
A
K
K
V
V
M
T
G
P
S
K
D
N
T
P
M
F
V
K
G
A
N
F
D
K
Y
--
A
G
Q
D
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
N
D
N
F
G
I
I
E
G
L
M
T
T
V
H
A
T
T
A
T
Q
K
T
V
D
G
P
S
H
--
K
D
W
R
G
G
R
G
A
S
Q
N
I
I
P
S
S
T
G
A
A
K
A
V
G
K
V
L
P
E
L
N
G
K
L
T
G
M
A
F
R
V
P
T
P
N
V
S
V
V
D
L
T
V
R
L
E
K
A
-
A
T
Y
-
E
Q
I
K
A
A
V
K
A
A
A
E
-------
G
-------
E
M
K
G
V
L
G
Y
T
E
D
D
V
V
S
T
D
F
N
G
E
V
C
T
S
V
F
D
A
K
A
G
I
A
L
N
D
N
F
V
K
L
V
S
W
Y
D
N
E
T
G
Y
S
N
K
V
L
D
L
I
A
H
I
S
K
---
62
PsiBlast_CBE
70.65
55%
-41
- C2 -
1GAE
1
G3P1_ECOLI
P:
[2-330]
--
I
K
V
G
I
N
G
F
G
R
I
G
R
I
V
F
R
A
A
Q
--
K
--
R
---
S
--
D
I
E
I
V
A
I
N
D
-
L
-
L
D
A
D
Y
M
A
Y
M
L
K
Y
D
S
T
H
G
R
F
D
G
T
-
V
E
V
K
D
-
G
H
L
I
V
N
G
K
K
I
R
V
T
A
E
R
D
P
A
N
L
K
W
D
E
V
G
V
D
V
V
A
E
A
T
G
L
F
L
T
D
E
T
A
R
K
H
I
T
A
G
A
K
K
V
V
M
T
G
P
S
K
D
N
T
P
M
F
V
K
G
A
N
F
D
K
Y
--
A
G
Q
D
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
N
D
N
F
G
I
I
E
G
L
M
T
T
V
H
A
T
T
A
T
Q
K
T
V
D
G
P
S
H
--
K
D
W
R
G
G
R
G
A
S
Q
N
I
I
P
S
S
T
G
A
A
K
A
V
G
K
V
L
P
E
L
N
G
K
L
T
G
M
A
F
R
V
P
T
P
N
V
S
V
V
D
L
T
V
R
L
E
K
A
-
A
T
Y
-
E
Q
I
K
A
A
V
K
A
A
A
E
-------
G
-------
E
M
K
G
V
L
G
Y
T
E
D
D
V
V
S
T
D
F
N
G
E
V
C
T
S
V
F
D
A
K
A
G
I
A
L
N
D
N
F
V
K
L
V
S
W
Y
D
T
E
T
G
Y
S
N
K
V
L
D
L
I
A
H
I
S
K
---
87
PsiBlast_CBE
70.64
54%
-38
- C2 -
4P8R
3
?
B:
[9-339]
M
V
I
R
V
G
I
N
G
F
G
R
I
G
R
V
V
F
R
A
A
Q
--
R
--
R
---
N
--
D
I
E
I
V
G
I
N
D
-
L
-
L
D
A
D
Y
M
A
Y
M
L
K
Y
D
S
T
H
G
R
F
E
G
A
-
V
E
V
Q
G
-
G
A
L
V
V
N
G
K
K
I
R
V
T
S
E
R
D
P
A
N
L
K
W
N
E
I
N
V
D
V
V
V
E
S
T
G
L
F
L
S
D
D
T
A
R
K
H
I
Q
A
G
A
K
K
V
V
I
T
G
P
S
K
D
D
T
P
M
F
V
M
G
V
N
H
T
T
Y
K
G
--
E
A
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
L
N
D
K
F
G
I
V
E
G
L
M
T
T
V
H
A
T
T
A
T
Q
K
T
V
D
G
P
S
Q
--
K
D
W
R
G
G
R
G
A
A
Q
N
I
I
P
S
S
T
G
A
A
K
A
V
G
K
I
I
P
S
L
N
G
K
L
T
G
M
A
F
R
V
P
T
P
N
V
S
V
V
D
L
T
V
R
L
E
R
P
-
A
T
Y
-
K
Q
I
C
D
A
I
K
A
A
S
E
-------
G
-------
E
L
K
G
I
L
G
Y
V
D
E
E
I
V
S
S
D
I
N
G
I
P
L
T
S
V
F
D
A
R
A
G
I
S
L
N
D
N
F
V
K
L
V
S
W
Y
D
N
E
T
G
Y
S
N
K
V
L
D
L
I
A
H
I
T
K
---
86
PsiBlast_CBE
70.57
54%
-39
- C2 -
4P8R
2
?
C:
[10-339]
-
V
I
R
V
G
I
N
G
F
G
R
I
G
R
V
V
F
R
A
A
Q
--
R
--
R
---
N
--
D
I
E
I
V
G
I
N
D
-
L
-
L
D
A
D
Y
M
A
Y
M
L
K
Y
D
S
T
H
G
R
F
E
G
A
-
V
E
V
Q
G
-
G
A
L
V
V
N
G
K
K
I
R
V
T
S
E
R
D
P
A
N
L
K
W
N
E
I
N
V
D
V
V
V
E
S
T
G
L
F
L
S
D
D
T
A
R
K
H
I
Q
A
G
A
K
K
V
V
I
T
G
P
S
K
D
D
T
P
M
F
V
M
G
V
N
H
T
T
Y
K
G
--
E
A
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
L
N
D
K
F
G
I
V
E
G
L
M
T
T
V
H
A
T
T
A
T
Q
K
T
V
D
G
P
S
Q
--
K
D
W
R
G
G
R
G
A
A
Q
N
I
I
P
S
S
T
G
A
A
K
A
V
G
K
I
I
P
S
L
N
G
K
L
T
G
M
A
F
R
V
P
T
P
N
V
S
V
V
D
L
T
V
R
L
E
R
P
-
A
T
Y
-
K
Q
I
C
D
A
I
K
A
A
S
E
-------
G
-------
E
L
K
G
I
L
G
Y
V
D
E
E
I
V
S
S
D
I
N
G
I
P
L
T
S
V
F
D
A
R
A
G
I
S
L
N
D
N
F
V
K
L
V
S
W
Y
D
N
E
T
G
Y
S
N
K
V
L
D
L
I
A
H
I
T
K
---
88
PsiBlast_CBE
70.54
54%
-41
- C2 -
4P8R
3
?
A:
[9-339]
M
V
I
R
V
G
I
N
G
F
G
R
I
G
R
V
V
F
R
A
A
Q
--
R
--
R
---
N
--
D
I
E
I
V
G
I
N
D
-
L
-
L
D
A
D
Y
M
A
Y
M
L
K
Y
D
S
T
H
G
R
F
E
G
A
-
V
E
V
Q
G
-
G
A
L
V
V
N
G
K
K
I
R
V
T
S
E
R
D
P
A
N
L
K
W
N
E
I
N
V
D
V
V
V
E
S
T
G
L
F
L
S
D
D
T
A
R
K
H
I
Q
A
G
A
K
K
V
V
I
T
G
P
S
K
D
D
T
P
M
F
V
M
G
V
N
H
T
T
Y
K
G
--
E
A
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
L
N
D
K
F
G
I
V
E
G
L
M
T
T
V
H
A
T
T
A
T
Q
K
T
V
D
G
P
S
Q
--
K
D
W
R
G
G
R
G
A
A
Q
N
I
I
P
S
S
T
G
A
A
K
A
V
G
K
I
I
P
S
L
N
G
K
L
T
G
M
A
F
R
V
P
T
P
N
V
S
V
V
D
L
T
V
R
L
E
R
P
-
A
T
Y
-
K
Q
I
C
D
A
I
K
A
A
S
E
-------
G
-------
E
L
K
G
I
L
G
Y
V
D
E
E
I
V
S
S
D
I
N
G
I
P
L
T
S
V
F
D
A
R
A
G
I
S
L
N
D
N
F
V
K
L
V
S
W
Y
D
N
E
T
G
Y
S
N
K
V
L
D
L
I
A
H
I
T
K
---
20
PsiBlast_PDB
70.44
56%
-39
- C2 -
1DC6
1
G3P1_ECOLI
A:
[2-330]
--
I
K
V
G
I
N
G
F
G
R
I
G
R
I
V
F
R
A
A
Q
--
K
--
R
---
S
--
D
I
E
I
V
A
I
N
D
-
L
-
L
D
A
D
Y
M
A
Y
M
L
K
Y
D
S
T
H
G
R
F
D
G
T
-
V
E
V
K
D
-
G
H
L
I
V
N
G
K
K
I
R
V
T
A
E
R
D
P
A
N
L
K
W
D
E
V
G
V
D
V
V
A
E
A
T
G
L
F
L
T
D
E
T
A
R
K
H
I
T
A
G
A
K
K
V
V
M
T
G
P
S
K
D
N
T
P
M
F
V
K
G
A
N
F
D
K
Y
--
A
G
Q
D
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
N
D
N
F
G
I
I
E
G
L
M
T
T
V
H
A
T
T
A
T
Q
K
T
V
D
G
P
S
H
--
K
D
W
R
G
G
R
G
A
S
Q
N
I
I
P
S
S
T
G
A
A
K
A
V
G
K
V
L
P
E
L
N
G
K
L
T
G
M
A
F
R
V
P
T
P
N
V
S
V
V
D
L
T
V
R
L
E
K
A
-
A
T
Y
-
E
Q
I
K
A
A
V
K
A
A
A
E
-------
G
-------
E
M
K
G
V
L
G
Y
T
E
D
D
V
V
S
T
D
F
N
G
E
V
C
T
S
V
F
D
A
K
A
G
I
A
L
N
D
N
F
V
K
L
V
S
W
Y
D
N
E
T
G
Y
S
N
K
V
L
D
L
I
A
H
I
S
K
---
121
HHSearch
64.89
55%
16
* C2 *
3PYM
3
G3P3_YEAST
A:
[1-331]
-
M
V
R
V
A
I
N
G
F
G
R
I
G
R
L
V
M
R
I
A
L
--
S
--
R
---
P
--
N
V
E
V
V
A
L
N
D
-
P
F
I
T
N
D
Y
A
A
Y
M
F
K
Y
D
S
T
H
G
R
Y
A
G
E
-
V
S
H
D
D
-
K
H
I
I
V
D
G
K
K
I
A
T
Y
Q
E
R
D
P
A
N
L
P
W
G
S
S
N
V
D
I
A
I
D
S
T
G
V
F
K
E
L
D
T
A
Q
K
H
I
D
A
G
A
K
K
V
V
I
T
A
P
S
S
T
-
A
P
M
F
V
M
G
V
N
E
E
K
Y
T
S
-
D
L
K
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
N
D
A
F
G
I
E
E
G
L
M
T
T
V
H
S
L
T
A
T
Q
K
T
V
D
G
P
-
S
H-
K
D
W
R
G
G
R
T
A
S
G
N
I
I
P
S
S
T
G
A
A
K
A
V
G
K
V
L
P
E
L
Q
G
K
L
T
G
M
A
F
R
V
P
T
V
D
V
S
V
V
D
L
T
V
K
L
N
K
E
-
T
T
Y
-
D
E
I
K
K
V
V
K
A
A
A
E
-------
G
-------
K
L
K
G
V
L
G
Y
T
E
D
A
V
V
S
S
D
F
L
G
D
S
H
S
S
I
F
D
A
S
A
G
I
Q
L
S
P
K
F
V
K
L
V
S
W
Y
D
N
E
Y
G
Y
S
T
R
V
V
D
L
V
E
H
V
A
K
---
120
HHSearch
64.87
54%
-4
- C2 -
3CPS
1
?
A:
[18-353]
--
G
T
L
G
I
N
G
F
G
R
I
G
R
L
V
L
R
A
C
M
--
E
--
R
---
N
--
D
I
T
V
V
A
I
N
D
-
P
F
M
D
V
E
Y
M
A
Y
L
L
K
Y
D
S
V
H
G
N
F
N
G
T
-
V
E
V
S
G
--
D
L
C
I
N
G
K
V
V
K
V
F
Q
A
K
D
P
A
E
I
P
W
G
A
S
G
A
Q
I
V
C
E
S
T
G
V
F
T
T
E
E
K
A
S
L
H
L
K
G
G
A
K
K
V
I
I
S
A
P
P
K
D
N
V
P
M
Y
V
M
G
V
N
N
T
E
Y
D
P
S
K
F
N
V
I
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
I
I
N
D
K
F
G
I
V
E
G
L
M
T
T
V
H
S
L
T
A
N
Q
L
T
V
D
G
P
-
S
KG-
D
W
R
A
G
R
C
A
G
N
N
I
I
P
A
S
T
G
A
A
K
A
V
G
K
V
I
P
A
L
N
G
K
L
T
G
M
A
I
R
V
P
T
P
D
V
S
V
V
D
L
T
C
K
L
A
K
P
-
A
S
I
-
E
E
I
Y
Q
A
V
K
E
A
S
N
-------
G
-------
P
M
K
G
I
M
G
Y
T
S
D
D
V
V
S
T
D
F
I
G
C
K
Y
S
S
I
F
D
K
N
A
C
I
A
L
N
D
S
F
V
K
L
I
S
W
Y
D
N
E
S
G
Y
S
N
R
L
V
D
L
A
V
Y
V
A
S
R
G
-
118
HHSearch
64.67
62%
18
- C2 -
1HDG
3
G3P_THEMA
O:
[1-331]
--
A
R
V
A
I
N
G
F
G
R
I
G
R
L
V
Y
R
I
I
Y
--
E
RK
N
---
P
--
D
I
E
V
V
A
I
N
D
-
L
-
T
D
T
K
T
L
A
H
L
L
K
Y
D
S
V
H
K
K
F
P
G
K
-
V
E
Y
T
E
-
N
S
L
I
V
D
G
K
E
I
K
V
F
A
E
P
D
P
S
K
L
P
W
K
D
L
G
V
D
F
V
I
E
S
T
G
V
F
R
N
R
E
K
A
E
L
H
L
Q
A
G
A
K
K
V
I
I
T
A
P
A
K
G
E
D
I
T
V
V
I
G
C
N
E
D
Q
L
K
P
-
E
H
T
I
I
S
C
A
S
C
T
T
N
S
I
A
P
I
V
K
V
L
H
E
K
F
G
I
V
S
G
M
L
T
T
V
H
S
Y
T
N
D
Q
R
V
L
D
L
P
-
H
--
K
D
L
R
R
A
R
A
A
A
V
N
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
V
P
E
V
K
G
K
L
D
G
M
A
I
R
V
P
T
P
D
G
S
I
T
D
L
T
V
L
V
E
K
E
-
T
T
V
-
E
E
V
N
A
V
M
K
E
A
T
E
-------
G
-------
R
L
K
G
I
I
G
Y
N
D
E
P
I
V
S
S
D
I
I
G
T
T
F
S
G
I
F
D
A
T
I
T
N
V
I
G
G
K
L
V
K
V
A
S
W
Y
D
N
E
Y
G
Y
S
N
R
V
V
D
T
L
E
L
L
L
K
---
54
PsiBlast_CBE
64.14
61%
13
- C2 -
1HDG
3
G3P_THEMA
Q:
[2-331]
---
R
V
A
I
N
G
F
G
R
I
G
R
L
V
Y
R
I
I
Y
ER
K
--
N
---
P
--
D
I
E
V
V
A
I
N
D
-
L
-
T
D
T
K
T
L
A
H
L
L
K
Y
D
S
V
H
K
K
F
P
G
K
-
V
E
Y
T
E
-
N
S
L
I
V
D
G
K
E
I
K
V
F
A
E
P
D
P
S
K
L
P
W
K
D
L
G
V
D
F
V
I
E
S
T
G
V
F
R
N
R
E
K
A
E
L
H
L
Q
A
G
A
K
K
V
I
I
T
A
P
A
K
G
E
D
I
T
V
V
I
G
C
N
E
D
Q
L
-
K
P
E
H
T
I
I
S
C
A
S
C
T
T
N
S
I
A
P
I
V
K
V
L
H
E
K
F
G
I
V
S
G
M
L
T
T
V
H
S
Y
T
N
D
Q
R
V
L
D
L
P
-
H
--
K
D
L
R
R
A
R
A
A
A
V
N
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
V
P
E
V
K
G
K
L
D
G
M
A
I
R
V
P
T
P
D
G
S
I
T
D
L
T
V
L
V
E
K
E
-
T
T
V
-
E
E
V
N
A
V
M
K
E
A
T
E
-------
G
-------
R
L
K
G
I
I
G
Y
N
D
E
P
I
V
S
S
D
I
I
G
T
T
F
S
G
I
F
D
A
T
I
T
N
V
I
G
G
K
L
V
K
V
A
S
W
Y
D
N
E
Y
G
Y
S
N
R
V
V
D
T
L
E
L
L
L
K
---
113
HHSearch
64.04
58%
16
- C2 -
1RM4
3
G3PA_SPIOL
O:
[1-335]
-
K
L
K
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
H
--
G
--
R
---
K
DS
P
L
D
V
V
V
I
N
D
-
T
-
G
G
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
D
A
D
-
V
K
T
A
G
D
S
A
I
S
V
D
G
K
V
I
K
V
V
S
D
R
N
P
V
N
L
P
W
G
D
M
G
I
D
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
L
Q
A
G
A
K
K
V
L
I
T
A
P
G
K
G
D
I
P
T
Y
V
V
G
V
N
E
E
G
Y
T
H
-
A
D
T
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
-
H
--
R
D
L
R
R
A
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
K
-
T
F
A
-
E
E
V
N
A
A
F
R
E
S
A
D
-------
N
-------
E
L
K
G
I
L
S
V
C
D
E
P
L
V
S
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
M
G
D
D
M
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
A
N
K
W
-
99
PsiBlast_CBE
64.00
54%
-5
- C2 -
3CPS
1
?
A:
[20-354]
----
L
G
I
N
G
F
G
R
I
G
R
L
V
L
R
A
C
M
--
E
--
R
---
N
--
D
I
T
V
V
A
I
N
D
P
F
-
M
D
V
E
Y
M
A
Y
L
L
K
Y
D
S
V
H
G
N
F
N
G
T
-
V
E
V
S
G
--
D
L
C
I
N
G
K
V
V
K
V
F
Q
A
K
D
P
A
E
I
P
W
G
A
S
G
A
Q
I
V
C
E
S
T
G
V
F
T
T
E
E
K
A
S
L
H
L
K
G
G
A
K
K
V
I
I
S
A
P
P
K
D
N
V
P
M
Y
V
M
G
V
N
N
T
E
Y
D
P
S
K
F
N
V
I
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
I
I
N
D
K
F
G
I
V
E
G
L
M
T
T
V
H
S
L
T
A
N
Q
L
T
V
D
G
P
-
S
KG-
D
W
R
A
G
R
C
A
G
N
N
I
I
P
A
S
T
G
A
A
K
A
V
G
K
V
I
P
A
L
N
G
K
L
T
G
M
A
I
R
V
P
T
P
D
V
S
V
V
D
L
T
C
K
L
A
K
P
-
A
S
I
-
E
E
I
Y
Q
A
V
K
E
A
S
N
-------
G
-------
P
M
K
G
I
M
G
Y
T
S
D
D
V
V
S
T
D
F
I
G
C
K
Y
S
S
I
F
D
K
N
A
C
I
A
L
N
D
S
F
V
K
L
I
S
W
Y
D
N
E
S
G
Y
S
N
R
L
V
D
L
A
V
Y
V
A
S
R
G
L
12
PsiBlast_PDB
63.40
61%
19
- C2 -
1HDG
3
G3P_THEMA
O:
[2-331]
---
R
V
A
I
N
G
F
G
R
I
G
R
L
V
Y
R
I
I
Y
ER
K
--
N
---
P
--
D
I
E
V
V
A
I
N
D
-
L
-
T
D
T
K
T
L
A
H
L
L
K
Y
D
S
V
H
K
K
F
P
G
K
-
V
E
Y
T
E
-
N
S
L
I
V
D
G
K
E
I
K
V
F
A
E
P
D
P
S
K
L
P
W
K
D
L
G
V
D
F
V
I
E
S
T
G
V
F
R
N
R
E
K
A
E
L
H
L
Q
A
G
A
K
K
V
I
I
T
A
P
A
K
G
E
D
I
T
V
V
I
G
C
N
E
D
Q
L
-
K
P
E
H
T
I
I
S
C
A
S
C
T
T
N
S
I
A
P
I
V
K
V
L
H
E
K
F
G
I
V
S
G
M
L
T
T
V
H
S
Y
T
N
D
Q
R
V
L
D
L
P
-
H
--
K
D
L
R
R
A
R
A
A
A
V
N
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
V
P
E
V
K
G
K
L
D
G
M
A
I
R
V
P
T
P
D
G
S
I
T
D
L
T
V
L
V
E
K
E
-
T
T
V
-
E
E
V
N
A
V
M
K
E
A
T
E
-------
G
-------
R
L
K
G
I
I
G
Y
N
D
E
P
I
V
S
S
D
I
I
G
T
T
F
S
G
I
F
D
A
T
I
T
N
V
I
G
G
K
L
V
K
V
A
S
W
Y
D
N
E
Y
G
Y
S
N
R
V
V
D
T
L
E
L
L
L
K
---
129
HHSearch
62.77
49%
4
- C2 -
3H9E
10
G3PT_HUMAN
O:
[6-338]
R
E
L
T
V
G
I
N
G
F
G
R
I
G
R
L
V
L
R
A
C
M
--
E
--
K
------
G
V
K
V
V
A
V
N
D
-
P
F
I
D
P
E
Y
M
V
Y
M
F
K
Y
D
S
T
H
G
R
Y
K
G
S
-
V
E
F
R
N
-
G
Q
L
V
V
D
N
H
E
I
S
V
Y
Q
C
K
E
P
K
Q
I
P
W
R
A
V
G
S
P
Y
V
V
E
S
T
G
V
Y
L
S
I
Q
A
A
S
D
H
I
S
A
G
A
Q
R
V
V
I
S
A
P
S
P
D
-
A
P
M
F
V
M
G
V
N
E
N
D
Y
N
P
G
S
M
N
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
H
E
R
F
G
I
V
E
G
L
M
T
T
V
H
S
Y
T
A
T
Q
K
T
V
D
G
P
-
S
R-
K
A
W
R
D
G
R
G
A
H
Q
N
I
I
P
A
S
T
G
A
A
K
A
V
T
K
V
I
P
E
L
K
G
K
L
T
G
M
A
F
R
V
P
T
P
D
V
S
V
V
D
L
T
C
R
L
A
Q
P
-
A
P
Y
-
S
A
I
K
E
A
V
K
A
A
A
K
-------
G
-------
P
M
A
G
I
L
A
Y
T
E
D
E
V
V
S
T
D
F
L
G
D
T
H
S
S
I
F
D
A
K
A
G
I
A
L
N
D
N
F
V
K
L
I
S
W
Y
D
N
E
Y
G
Y
S
H
R
V
V
D
L
L
R
Y
M
F
S
R
--
126
HHSearch
61.64
54%
17
- C2 -
4BOY
1
?
A:
[17-354]
S
M
V
R
V
A
I
N
G
F
G
R
I
G
R
N
F
M
R
C
W
L
--
Q
--
R
KAN
S
--
K
L
E
I
V
G
I
N
D
-
T
-
S
D
P
R
T
N
A
H
L
L
K
Y
D
S
M
L
G
I
F
Q
D
A
E
I
T
A
D
D
-
D
C
I
Y
A
G
G
H
A
V
K
C
V
S
D
R
N
P
E
N
L
P
W
S
A
W
G
I
D
L
V
I
E
A
T
G
V
F
T
S
R
E
G
A
S
K
H
L
S
A
G
A
K
K
V
L
I
T
A
P
G
K
G
N
I
P
T
Y
V
V
G
V
N
H
H
T
Y
D
P
-
S
E
D
I
V
S
N
A
S
C
T
T
N
C
L
A
P
I
V
K
V
L
H
E
A
F
G
I
Q
Q
G
M
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
-
H
--
R
D
L
R
R
A
R
A
A
A
M
N
I
V
P
T
S
T
G
A
A
K
A
V
G
L
V
I
P
E
L
Q
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
F
V
A
Q
V
E
K
P
-
T
I
A
-
E
Q
V
N
Q
V
I
K
E
A
S
E
-------
T
-------
T
M
K
G
I
I
H
Y
S
E
L
E
L
V
S
S
D
Y
R
G
H
N
A
S
S
I
L
D
A
S
L
T
M
V
L
G
G
N
L
V
K
V
V
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
L
D
L
A
E
H
M
A
A
H
W
A
98
PsiBlast_CBE
61.43
54%
8
- C2 -
3CPS
1
?
B:
[20-354]
----
L
G
I
N
G
F
G
R
I
G
R
L
V
L
R
A
C
M
--
E
--
R
---
N
--
D
I
T
V
V
A
I
N
D
P
F
-
M
D
V
E
Y
M
A
Y
L
L
K
Y
D
S
V
H
G
N
F
N
G
T
-
V
E
V
S
--
K
D
L
C
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N
G
K
V
V
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V
F
Q
A
K
D
P
A
E
I
P
W
G
A
S
G
A
Q
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C
E
S
T
G
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F
T
T
E
E
K
A
S
L
H
L
K
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G
A
K
K
V
I
I
S
A
P
P
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N
V
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M
Y
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M
G
V
N
N
T
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Y
D
P
S
K
F
N
V
I
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
I
I
N
D
K
F
G
I
V
E
G
L
M
T
T
V
H
S
L
T
A
N
Q
L
T
V
D
G
P
-
S
K--
D
W
R
A
G
R
C
A
G
N
N
I
I
P
A
S
T
G
A
A
K
A
V
G
K
V
I
P
A
L
N
G
K
L
T
G
M
A
I
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V
P
T
P
D
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V
V
D
L
T
C
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L
A
K
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-
A
S
I
-
E
E
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Y
Q
A
V
K
E
A
S
N
-------
G
-------
P
M
K
G
I
M
G
Y
T
S
D
D
V
V
S
T
D
F
I
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C
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Y
S
S
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N
A
C
I
A
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L
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S
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N
R
L
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D
L
A
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Y
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A
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R
G
L