@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu34930: (2016-07-29 )
MFMFEKPHGMRDTLPGLYETKKKVRRSLTDLIDKWGYQFMETPTLEFYDTVGVQSAIEEQQLFKLLDQDGKTLVLRPDMTGPIARVAASKLLKHGHPLRVGYAANVFRAQEREGGRPAEFEQVGVELIGDGTTSADAEVIALVVGALKNAGLASFKIAIGHAGIADALFVEVLGNVERADVLRRFLYEKNYVGYREHVKSLPLSSIDKSRLLELLELRGGIEVCGRAEEIVDSAQGKSVVDELKALWDILEDYGCTENVRLDLNMVSHMSYYTGILFEVYAENVGFVIGSGGRYNKLLGHFDSPAPATGFGLRIDRLIEALHMKDEPCEIDAVIFSKEQRAQAIAYANEERMKGNKVVLQDLSGIENIDQMTKSFANVTYFIGARKEEQNG
Atome Classification :
(20 SA)
.........10....---....20........30.----.......40.....----...50-...---.--....--60.......-.70........80....-....90.--.......100.......110--.......120.......130-.-.......140.......150..------------.....160....---...170......-.180....---...190-......--..200--......-..210.......220--..--------....--.---.---230-------.......240----......-------..250....-...-260..--.....270.......280.-----.---..-...290.......300..---..--....310.......320--...----..-----.---.--.330.-.--.....340-.......350.--......360-..-.--...-...370.......380.......390
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MFMFEKPHGMRDTL
P
---
G
L
Y
E
T
K
K
K
V
R
R
S
L
T
D
L
I
----
D
K
W
G
Y
Q
FMETPT
L
E
----
F
Y
D
TV-
G
V
Q
---
S
--
A
I
E
E
--
Q
Q
L
F
K
L
L
DQ-DG
K
T
L
V
LRPDMTG
P
I
A
R
-
V
A
A
S
K
L
L
--KHGH
P
L
R
V
GY
A
A
N
V
F
R
A
Q
ER--EGGR
P
A
E
F
E
Q
V
G
V
E
L
IGD-G-T-TSA
D
A
E
V
I
A
L
V
V
G
A
L
KNAGL
A
S
------------
F
K
I
A
IGHAG
I
A
D
---
A
L
F
V
E
V
LGN
V
E
R
-
A
D
V
L
R
R
F
L
---
Y
EKNY--V
G
Y
R
E
H
--
V
K
SL---PLSSI
D
-
K
S
R
L
L
E
L
L
E
LRG
G
-
I
--
E
V--------CG
R
A
--
E
---
E
---
I
V
D
-------
S
AQ
G
K
S
V
V
D
-----
E
L
K
A
L
W
-------
D
I
L
E
DYGCT-E
N
V
-
R
L
D
L
N
--
M
V
S
H
M
S
Y
Y
T
G
I
L
F
E
V
Y
A
EN-----V---
G
F
-
V
IGSGGR
Y
N
K
L
L
GHF-DS---PA--PATG
F
G
L
R
I
D
R
L
I
E
A
L
---HMK----DE-----P---C--E
I
D
A
V
-
I
--F
S
K
E
Q
R
A
Q
-
A
I
AYA
N
E
ERMK--G
N
K
V
V
L
Q
---
D
L
-S--G
I
E
-
N
I
D
Q
M
T
K
S
FAN
V
T
Y
F
I
GARKEEQNG
1
PsiBlast_PDB
97.95
56%
-139
- C3 -
3OD1
5
HISZ_BACHD
A:
[8-391]
-
F
M
F
E
K
P
F
G
M
R
D
T
L
P
---
E
W
Y
K
T
K
K
N
I
C
D
Q
M
T
E
E
I
----
N
L
W
G
Y
D
M
I
E
T
P
T
L
E
----
Y
Y
E
T
V
-
G
V
V
---
S
--
A
I
L
D
--
Q
Q
L
F
K
L
L
D
Q
-
Q
G
N
T
L
V
L
R
P
D
M
T
A
P
I
A
R
-
L
V
A
S
S
L
K
--
D
R
A
Y
P
L
R
L
A
Y
Q
S
N
V
Y
R
A
Q
Q
-----
G
K
P
A
E
F
E
Q
L
G
V
E
L
I
G
D
-
G
-
T
-
A
S
A
D
G
E
V
I
A
L
M
I
A
A
L
K
R
A
G
L
S
E
------------
F
K
V
A
I
G
H
V
G
Y
V
N
---
A
L
L
M
D
V
V
G
N
E
Q
R
-
A
D
R
L
R
R
F
L
---
Y
E
K
N
Y
--
V
G
Y
R
E
H
--
V
K
S
L
---
N
L
S
T
I
D
-
K
S
R
L
M
N
L
L
S
L
R
G
G
-
R
--
A
A
--------
I
E
E
A
--
R
---
G
---
L
I
Q
-------
T
E
K
G
K
T
A
L
A
-----
E
M
T
K
L
Y
-------
E
V
L
E
S
Y
G
A
S
-
E
Y
V
-
K
F
D
L
T
--
L
V
L
H
M
S
Y
Y
T
G
V
V
F
E
G
Y
G
N
R
-----
L
---
G
V
-
P
L
C
S
G
G
R
Y
D
E
L
L
S
K
F
-
H
R
---
P
A
--
Q
A
T
G
F
G
V
R
I
D
L
L
V
E
A
L
---
N
-------------
G
---
H
--
E
Q
T
C
I
-
L
--
F
S
N
E
R
R
F
E
-
A
I
E
L
A
R
K
K
R
A
N
--
G
E
A
V
V
L
Q
---
D
L
-
A
--
G
V
T
-
D
V
D
A
M
S
S
N
Y
Q
D
V
I
Y
C
I
G
--------
56
HHSearch
89.90
58%
-58
- C3 -
3OD1
5
HISZ_BACHD
A:
[8-373]
-
F
M
F
E
K
P
F
G
M
R
D
T
L
P
---
E
W
Y
K
T
K
K
N
I
C
D
Q
M
T
E
E
I
----
N
L
W
G
Y
D
M
I
E
T
P
T
L
E
----
Y
Y
E
T
V
-
G
V
V
---
S
--
A
I
L
D
--
Q
Q
L
F
K
L
L
D
Q
-
Q
G
N
T
L
V
L
R
P
D
M
T
A
P
I
A
R
-
L
V
A
S
S
L
K
--
D
R
A
Y
P
L
R
L
A
Y
Q
S
N
V
Y
R
A
Q
Q
-----
G
K
P
A
E
F
E
Q
L
G
V
E
L
I
G
D
-
G
-
T
-
A
S
A
D
G
E
V
I
A
L
M
I
A
A
L
K
R
A
G
L
S
E
------------
F
K
V
A
I
G
H
V
G
Y
V
N
---
A
L
L
M
D
V
V
G
N
E
Q
R
-
A
D
R
L
R
R
F
L
---
Y
E
K
N
Y
--
V
G
Y
R
E
H
V
-
K
S
L
----
N
L
S
T
I
D
-
K
S
R
L
M
N
L
L
S
L
R
G
G
-
R
--
A
A
--------
I
E
E
A
--
R
---
G
---
L
I
Q
-------
T
E
K
G
K
T
A
L
A
-----
E
M
T
K
L
Y
-------
E
V
L
E
S
Y
G
A
S
-
E
Y
V
-
K
F
D
L
T
--
L
V
L
H
M
S
Y
Y
T
G
V
V
F
E
G
Y
G
N
R
-----
L
---
G
V
-
P
L
C
S
G
G
R
Y
D
E
L
L
S
K
F
-
H
R
---
P
A
--
Q
A
T
G
F
G
V
R
I
D
L
L
V
E
A
L
---
N
-----------------
G
H-
E
Q
T
C
I
-
L
--
F
-
S
N
E
R
R
F
E
A
I
E
L
A
R
K
K
R
A
N
--
G
E
A
V
V
L
Q
---
D
L
-
A
--
G
V
---------------------------
55
HHSearch
71.99
21%
-48
- C3 -
4X5O
-
SYHC_HUMAN
A:
[54-473]
-
F
V
L
K
T
P
K
G
T
R
D
Y
S
P
---
R
Q
M
A
V
R
E
K
V
F
D
V
I
I
R
C
F
----
K
R
H
G
A
E
V
I
D
T
P
V
F
E
----
L
K
E
T
L
-
M
G
K
---------
S
--
K
L
I
Y
D
L
K
D
Q
-
G
G
E
L
L
S
L
R
Y
D
L
T
V
P
F
A
R
-
Y
L
A
M
N
K
-----
L
T
N
I
K
R
Y
H
I
A
K
V
Y
R
R
D
N
P
AM
T
R
G
R
Y
R
E
F
Y
Q
C
D
F
D
I
A
G
N
-
F
-
D
P
M
I
P
D
A
E
C
L
K
I
M
C
E
I
L
S
S
L
Q
I
G
D
------------
F
L
V
K
V
N
D
R
R
I
L
D
---
G
M
F
A
I
C
G
V
S
D
S
K
-
F
R
T
I
C
S
S
V
---
D
K
L
D
K
--
V
S
W
E
E
V
K
-
N
E
M
V
GEK
G
L
A
P
E
V
-
A
D
R
I
G
D
Y
V
Q
Q
H
G
G
-
V
--
S
L
--------
V
E
Q
L
--
L
---
Q
D
P
K
L
S
Q
-------
N
K
Q
A
L
E
G
L
G
-----
D
L
K
L
L
F
-------
E
Y
L
T
L
F
G
I
D
-
D
K
I
-
S
F
D
L
S
--
L
A
R
G
L
D
Y
Y
T
G
V
I
Y
E
A
V
L
L
----------
V
G
-
S
V
A
A
G
G
R
Y
D
G
L
V
G
M
F
-
D
P
KGR
K
V
--
P
C
V
G
L
S
I
G
V
E
R
I
F
S
I
V
---
E
Q
R
----
L
E
ALEEK
I
R--
T
T-
E
T
Q
V
L
V
A
--
S
A
Q
K
K
L
L
E
E
R
L
K
L
V
S
E
L
W
D
A
--
G
I
K
A
E
L
L
---
Y
K
-
K
NP
K
L
L
N
Q
L
Q
Y
C
E
E
A
G
I
P
L
V
A
I
I
G
E
Q
E
L
K
D
--
64
HHSearch
70.47
29%
-25
- C3 -
3RAC
6
?
A:
[23-367]
---
A
D
R
P
P
G
M
Q
D
G
Y
P
---
D
F
A
K
R
R
R
A
V
E
T
R
L
L
S
F
V
----
E
D
A
G
Y
E
P
V
T
S
G
L
F
E
----
Y
V
D
T
L
-
L
R
A
---
R
S-
P
E
S
S
--
R
D
W
I
R
L
F
D
G
-
G
G
D
A
V
A
L
R
P
E
M
T
P
S
I
A
R
-
M
A
A
P
R
V
A
--
A
G
R
T
P
I
R
W
C
Y
C
E
R
V
Y
R
R
T
--------
A
A
E
S
T
Q
V
G
I
E
R
I
G
E
-
E
A
S
-
V
D
V
D
M
D
V
L
R
L
L
H
E
A
S
A
A
A
G
V
R
H
------------
H
R
I
V
V
S
H
A
R
L
V
P
---
R
L
L
D
A
L
G
I
S
A
S
L
-
S
R
A
F
L
A
C
L
---
T
S
G
N
Y
--
V
Q
F
R
E
L
W
-
Q
L
H
A
------
A
K
D
-
V
D
L
L
A
N
L
L
T
W
S
P
A
-
E
R-
D
A
AKRS
R
E
A
S
D
R
E
L
--
E
---
A
---
L
L
R
DAVD
P
R
A
A
A
D
V
R
D
A
W
R
-----
Y
L
C
R
L
A
-------
E
A
L
H
D
S
G
L
A
S
D
V
V
-
T
F
D
L
A
--
L
H
R
E
L
D
Y
Y
T
G
L
V
F
E
M
F
A
P
G
-----
V
---
G
A
-
P
I
A
Q
G
G
R
Y
D
E
L
L
A
Q
F
-
G
A
---
G
A
--
P
A
V
G
F
A
F
E
V
E
R
V
M
A
V
L
---
E
A
Q
----
E
-----------------------------------------------------------------------------------------
59
HHSearch
69.62
21%
-15
- C3 -
4G84
1
SYHC_HUMAN
A:
[13-430]
--
V
L
K
T
P
K
G
T
R
D
Y
S
P
---
R
Q
M
A
V
R
E
K
V
F
D
V
I
I
R
C
F
----
K
R
H
G
A
E
V
I
D
T
P
V
F
E
----
L
K
E
T
L
-
M
G
K
---
Y
--
G
------
L
I
Y
D
L
K
D
Q
-
G
G
E
L
L
S
L
R
Y
D
L
T
V
P
F
A
R
-
Y
L
A
M
N
K
-----
L
T
N
I
K
R
Y
H
I
A
K
V
Y
R
R
D
N
------
R
Y
R
E
F
Y
Q
C
D
F
D
I
A
G
N
-
F
-
D
P
M
I
P
D
A
E
C
L
K
I
M
C
E
I
L
S
S
L
Q
I
G
D
------------
F
L
V
K
V
N
D
R
R
I
L
D
---
G
M
F
A
I
C
G
V
S
D
S
K
-
F
R
T
I
C
S
S
V
---
D
K
L
D
K
--
V
S
W
E
E
V
K
-
N
E
M
V
GEK
G
L
A
P
E
V
-
A
D
R
I
G
D
Y
V
Q
Q
H
G
G
-
V
--
S
L
--------
V
E
Q
L
--
L
Q
D
P
K
---
L
S
Q
-------
N
K
Q
A
L
E
G
L
G
-----
D
L
K
L
L
F
-------
E
Y
L
T
L
F
G
I
D
-
D
K
I
-
S
F
D
L
S
--
L
A
R
G
L
D
Y
Y
T
G
V
I
Y
E
A
V
L
L
Q
-----
T
PLG
V
G
-
S
V
A
A
G
G
R
Y
D
G
L
V
G
M
F
-
D
P
KG
R
K
V
--
P
C
V
G
L
S
I
G
V
E
R
I
F
S
I
V
---
E
Q
R
----
L
E
A
L
EEK
I
R--
T
T-
E
T
Q
V
L
V
A
--
S
A
Q
K
K
L
L
E
E
R
L
K
L
V
S
E
L
W
D
A
--
G
I
K
A
E
L
L
---
Y
K
-
K
NP
K
L
L
N
Q
L
Q
Y
C
E
E
A
G
I
P
L
V
A
I
I
G
E
Q
E
L
K
---
2
PsiBlast_PDB
66.52
29%
-3
- C3 -
3RAC
6
?
A:
[24-368]
----
D
R
P
P
G
M
Q
D
G
Y
P
---
D
F
A
K
R
R
R
A
V
E
T
R
L
L
S
F
V
----
E
D
A
G
Y
E
P
V
T
S
G
L
F
E
----
Y
V
D
T
L
L
R
A
R
---
S
--
P
E
S
S
--
R
D
W
I
R
L
F
D
G
-
G
G
D
A
V
A
L
R
P
E
M
T
P
S
I
A
R
-
M
A
A
P
R
V
A
--
A
G
R
T
P
I
R
W
C
Y
C
E
R
V
Y
R
R
T
--------
A
A
E
S
T
Q
V
G
I
E
R
I
G
E
E
A
-
S
-
V
D
V
D
M
D
V
L
R
L
L
H
E
A
S
A
A
A
G
V
R
H
------------
H
R
I
V
V
S
H
A
R
L
V
P
---
R
L
-
L
D
A
L
G
I
S
---
A
S
L
S
R
A
F
L
A
C
L
T
S
G
N
Y
--
V
Q
F
R
E
L
--
W
Q
L
H
---
A
A
K
D
V
D
-
L
--
L
A
N
L
L
T
W
S
P
A
E
R
--
D
A
--------
A
K
R
S
--
R
---
E
---
A
S
D
R
E
L
----
E
A
L
L
R
D
A
V
D
P
R
A
A
A
D
V
R
D
A
W
R
Y
L
C
R
L
A
E
A
L
H
D
S
G
L
A
-
S
D
V
V
T
F
D
L
A
--
L
H
R
E
L
D
Y
Y
T
G
L
V
F
E
M
F
A
P
G
-----
V
---
G
A
-
P
I
A
Q
G
G
R
Y
D
E
L
L
A
Q
F
-
G
A
---
G
A
--
P
A
V
G
F
A
F
E
V
E
R
V
M
A
V
L
---
E
A
Q
----
E
E
----------------------------------------------------------------------------------------
58
HHSearch
65.02
24%
5
* C3 *
1WU7
-
SYH_THEAC
A:
[3-396]
R
L
Q
I
E
K
I
R
G
F
R
D
F
Y
P
---
E
D
M
D
V
E
K
F
I
F
K
T
A
E
E
A
A
----
E
A
F
G
F
R
R
I
D
F
P
S
L
E
----
Y
L
D
L
Y
-
R
I
K
---
S
G-
E
E
L
L
--
Q
Q
T
Y
S
F
V
D
K
-
G
G
R
E
V
T
L
I
P
E
A
T
P
S
T
V
R
-
M
V
T
S
R
K
---
D
L
Q
R
P
L
R
W
Y
S
F
P
K
V
W
R
Y
E
E
P
--
Q
A
G
R
Y
R
E
H
Y
Q
F
N
A
D
I
F
G
S
-
D
-
S
-
P
E
A
D
A
E
V
I
A
L
A
S
S
I
L
D
R
L
G
L
Q
D
I-----------
Y
E
I
R
I
N
S
R
K
I
M
E
---
E
I
I
G
G
M
T
S
S
--
D
-
P
F
S
V
F
S
I
I
---
D
R
Y
H
K
--
I
S
R
E
E
F
V
-
D
Q
L
R
S
A
-
G
I
G
E
D
G
-
V
S
M
I
A
D
L
C
S
G
T
------
R
G
--------
I
D
E
M
--
A
---
R
---
I
T
---------
G
K
S
S
E
E
I
A
-----
R
M
A
A
V
E
-------
D
L
L
A
S
Y
G
V
K
--
N
V
-
R
Y
D
F
S
--
I
V
R
G
L
S
Y
Y
T
G
I
V
F
E
A
Y
D
R
S
G----
Q
---
F
R
-
A
I
L
G
G
G
R
Y
D
N
L
A
S
L
M
-
S
G
E
--
S
V
--
P
A
V
G
F
G
M
G
D
A
V
I
S
L
L
L
---
K
R
E
----
N
V
-----
Q
I
--
P
R
E
K
K
S
V
Y
I
C
--
R
V
G
K
I
N
S
S
I
M
N
E
Y
S
R
K
L
R
E
R
--
G
M
N
V
T
V
E
---
I
M
E
R
--
G
L
S
A
Q
L
K
Y
A
S
A
I
G
A
D
F
A
V
I
F
G
E
R
D
L
E
R
--
66
HHSearch
63.07
22%
5
- C3 -
1H4V
1
SYH_THET2
B:
[2-391]
--
T
A
R
A
V
R
G
T
K
D
L
F
G
---
K
E
L
R
M
H
Q
R
I
V
A
T
A
R
K
V
L
----
E
A
A
G
A
L
E
L
V
T
P
I
F
E
----
E
T
Q
V
F
-
E
K
G
---
V
GA------
K
E
M
F
T
F
Q
D
R
-
G
G
R
S
L
T
L
R
P
E
G
T
A
A
M
V
R
-
A
Y
L
E
H
G
M
K-
V
W
P
Q
P
V
R
L
W
M
A
G
P
M
F
R
A
E
R
P
------
Y
R
Q
F
H
Q
V
N
Y
E
A
L
G
S
-
E
-
N
-
P
I
L
D
A
E
A
V
V
L
L
Y
E
C
L
K
E
L
G
L
R
R
------------
L
K
V
K
L
S
S
V
G
D
P
E
---
D
R
A
R
Y
--------
N
A
Y
L
R
E
V
L
---
S
P
H
-
R
--
E
A
L
S
E
D
SK
E
R
L
-----------
E
E
N
P
M
R
I
L
D
S
K
S
E
-
R
DQ
A
L
--------
L
K
E
L
GV
R
---
P
---
M
L
D
--------
F
L
G
E
E
A
R
A
-----
H
L
K
E
V
E
-------
R
H
L
E
R
L
S
V
---
P
Y
-
E
L
E
P
A
--
L
V
R
G
L
D
Y
Y
V
R
T
A
F
E
V
H
H
------------
S
-
A
L
G
G
G
G
R
Y
D
G
L
S
E
L
L
-
G
G
P--
R
V
--
P
G
V
G
F
A
F
G
V
E
R
V
A
L
A
L
---
E
A
E
----
G
F
-----
G
LPE
E
K-
G
P
D
L
Y
L
I
--
P
L
T
E
E
A
V
A
E
A
F
Y
L
A
E
A
L
R
P
R
---
L
R
A
E
Y
A
---
L
A
P
R
--
K
P
A
K
G
L
E
E
A
L
K
R
G
A
A
F
A
G
F
L
G
E
D
E
L
R
A
--
63
HHSearch
62.94
25%
-27
- C3 -
1QE0
-
SYH_STAAU
A:
[2-393]
---
I
K
I
P
R
G
T
Q
D
I
L
P
---
E
D
S
K
K
W
R
Y
I
E
N
Q
L
D
E
L
M
----
T
F
Y
N
Y
K
E
I
R
T
P
I
F
E
----
S
T
D
L
F
-
A
R
--------------
E
M
Y
T
F
K
D
K
-
G
D
R
S
I
T
L
R
P
E
G
T
A
A
V
V
R
-
S
Y
I
E
H
K
M
QG
N
P
N
Q
P
I
K
L
Y
Y
N
G
P
M
F
R
Y
---------
Y
R
Q
F
N
Q
F
G
V
E
A
I
G
A
-
E
-
N
-
P
S
V
D
A
E
V
L
A
M
V
M
H
I
Y
Q
S
F
G
L
K
H
------------
L
K
L
V
I
N
S
V
G
D
M
A
---
S
R
K
E
Y
N
E
--------
A
L
V
K
H
F
---
E
P
------
V
I
H
E
F
C-
S
D
C
------
Q
S
R
L
-
H
T
D
P
M
R
I
L
---------------------
T
A
--
P
---
R
---
I
T
D
--------
F
L
N
E
E
S
K
A
-----
Y
Y
E
Q
V
K
-------
A
Y
L
D
D
L
G
I
---
P
Y
-
T
E
D
P
N
--
L
V
R
G
L
D
Y
Y
T
H
T
A
F
E
L
M
M
D
N
PNYDG
A
---
I
T
-
T
L
C
G
G
G
R
Y
N
G
L
L
E
L
L
-
D
G
P--
S
E
--
T
G
I
G
F
A
L
S
I
E
R
L
L
L
A
L
---
E
E
E
----
G
I
-----
E
LDI
E
E-
N
L
D
L
F
I
V
--
T
M
G
D
Q
A
D
R
Y
A
V
K
L
L
N
H
L
R
H
N
--
G
I
K
A
D
K
D
---
Y
L
Q
R
--
K
I
K
G
Q
M
K
Q
A
D
R
L
G
A
K
F
T
I
V
I
G
D
Q
E
L
E
N
--
11
PsiBlast_PDB
62.70
25%
3
- C3 -
4YRC
8
?
A:
[26-400]
M
V
E
T
E
P
V
Q
G
C
R
D
F
P
P
-------
E
A
M
R
C
R
R
H
L
F
D
V
F
H
A
T
A
K
T
F
G
F
E
E
Y
D
A
P
V
L
E
-----
S
E
E
L
-
Y
I
R
---
K
--
A
G
E
E
I
T
E
Q
M
F
N
F
I
T
K
-
G
G
H
R
V
A
L
R
P
E
M
T
P
S
L
A
R
-
L
L
L
G
K
G
R
--
S
L
L
L
P
A
K
W
Y
S
I
P
Q
C
W
R
Y
E
A
I
--
T
R
--
R
R
E
H
Y
Q
W
N
M
D
I
V
G
V
-
K
-
S
-
V
S
A
E
V
E
L
V
C
A
A
C
W
A
M
R
S
L
G
L
S
S
KD
V
G
I
K
V
N
S
R
K
V
L
Q
T
V
V
E
Q
A
G
V
T
S
---
D
K
F
A
P
V
C
V
I
V
D
K
-
M
E
K
I
P
R
E
E
---
V
E
A
Q
L
--
A
-------
V
L
G
L
---
E
P
T
V
V
D
-
A
--
I
T
T
T
L
S
L
K
S
I
-
D
--
E
I
--------
A
Q
R
V
--
G
---
E
----------------
E
H
E
A
V
K
-----
E
L
R
Q
F
F
-------
E
Q
V
E
A
Y
G
Y
G
-
D
W
V
-
L
F
D
A
S
--
V
V
R
G
L
A
Y
Y
T
G
I
V
F
E
G
F
D
R
E
-----
G
---
K
F
R
A
L
C
G
G
G
R
Y
D
N
L
L
T
T
Y
-
G
S
---
P
T
P
I
P
C
A
G
F
G
F
G
D
C
V
I
V
E
L
L
---
Q
E
K
RLLP
D
I
-----
P
---
H
--
V
V
D
D
V
-
V
I
P
F
D
E
S
M
R
P
H
-
A
L
A
V
L
R
R
L
R
D
A
--
G
R
-------------------------------------------
67
HHSearch
62.65
24%
4
- C3 -
1Z7M
1
HISZ_LACLA
A:
[22-338]
---
Y
L
L
P
E
E
S
A
E
M
T
L
---
N
Q
V
K
S
L
R
Q
I
E
G
R
L
R
K
L
F
----
S
L
K
N
Y
Q
E
V
M
P
P
S
F
E
----
Y
T
Q
L
Y
-
T
A
L
ESN
G
K-
T
F
N
Q
--
E
K
M
F
Q
F
I
K
H
-
E
G
Q
S
I
T
L
R
Y
D
F
T
L
P
L
V
R
-
L
Y
S
Q
I
K
D
----
S
T
S
A
R
Y
S
Y
F
G
K
I
F
R
K
E
K
---------
E
N
Y
Q
I
G
I
E
L
F
G
E
-
S
-
A
-
D
K
S
E
L
E
I
L
S
L
A
L
Q
V
I
E
Q
L
G
L
N
K
------------
T
V
F
E
I
G
S
A
K
F
F
Q
---
R
L
C
Q
L
A
D
G
S
T
----
E
L
L
T
E
L
L
---
L
K
K
D
L
--
S
G
L
N
A
F
I
-
E
K
N
----
N
F
S
K
E
L
-
R
G
L
L
K
E
I
F
I
---
T
----
N
E
--------
L
S
R
L
--
E
---
N
---
L
V
T
-------
N
T
K
D
D
V
L
I
S
-----
S
F
D
Q
L
K
-------
E
F
S
E
K
L
S
M
I
-
K
P
I
-
I
I
D
L
G
--
M
V
P
K
M
D
Y
Y
T
D
L
M
F
K
A
Y
S
S
A
-----
A
---
N
Q
-
P
I
L
S
G
G
R
Y
D
Q
L
L
S
N
F
-
Q
E
---
E
A
--
F
A
I
G
F
C
C
H
M
D
T
I
L
K
A
L
---
E
R
Q
----
E
-----------------------------------------------------------------------------------------
20
PsiBlast_PDB
62.60
25%
-2
- C3 -
4YRS
2
?
A:
[26-400]
M
V
E
T
E
P
V
Q
G
C
R
D
F
P
P
-------
E
A
M
R
C
R
R
H
L
F
D
V
F
H
A
T
A
K
T
F
G
F
E
E
Y
D
A
P
V
L
E
-----
S
E
E
L
-
Y
I
R
---
K
--
A
G
E
E
I
T
E
Q
M
F
N
F
I
T
K
-
G
G
H
R
V
A
L
R
P
E
M
T
P
S
L
A
R
-
L
L
L
G
K
G
R
--
S
L
L
L
P
A
K
W
Y
S
I
P
Q
C
W
R
Y
E
A
I
--
T
R
--
R
R
E
H
Y
Q
W
N
M
D
I
V
G
V
-
K
-
S
-
V
S
A
E
V
E
L
V
C
A
A
C
W
A
M
R
S
L
G
L
S
S
KD
V
G
I
K
V
N
S
R
K
V
L
Q
T
V
V
E
Q
A
G
V
T
S
---
D
K
F
A
P
V
C
V
I
V
D
K
-
M
E
K
I
P
R
E
E
---
V
E
A
Q
L
--
A
-------
V
L
G
L
---
E
P
T
V
V
D
-
A
--
I
T
T
T
L
S
L
K
S
I
-
D
--
E
I
--------
A
Q
R
V
--
G
---
E
----------------
E
H
E
A
V
K
-----
E
L
R
Q
F
F
-------
E
Q
V
E
A
Y
G
Y
G
-
D
W
V
-
L
F
D
A
S
--
V
V
R
G
L
A
Y
Y
T
G
I
V
F
E
G
F
D
R
E
-----
G
---
K
F
R
A
L
C
G
G
G
R
Y
D
N
L
L
T
T
Y
-
G
S
---
P
T
P
I
P
C
A
G
F
G
F
G
D
C
V
I
V
E
L
L
---
Q
E
K
RLL
P
D
I
-----
P
---
H
--
V
V
D
D
V
-
V
I
P
F
D
E
S
M
R
P
H
-
A
L
A
V
L
R
R
L
R
D
A
--
G
R
-------------------------------------------
13
PsiBlast_PDB
62.54
25%
7
- C3 -
4YRI
8
?
A:
[26-401]
M
V
E
T
E
P
V
Q
G
C
R
D
F
P
P
-------
E
A
M
R
C
R
R
H
L
F
D
V
F
H
A
T
A
K
T
F
G
F
E
E
Y
D
A
P
V
L
E
-----
S
E
E
L
-
Y
I
R
---
K
--
A
G
E
E
I
T
E
Q
M
F
N
F
I
T
K
-
G
G
H
R
V
A
L
R
P
E
M
T
P
S
L
A
R
-
L
L
L
G
K
G
R
--
S
L
L
L
P
A
K
W
Y
S
I
P
Q
C
W
R
Y
E
-------
R
R
R
E
H
Y
Q
W
N
M
D
I
V
G
V
-
K
-
S
-
V
S
A
E
V
E
L
V
C
A
A
C
W
A
M
R
S
L
G
L
S
S
KD
V
G
I
K
V
N
S
R
K
V
L
Q
T
V
V
E
Q
A
G
-
T
S
---
D
K
F
A
P
V
C
V
I
V
D
K
-
M
E
--
P
R
E
E
---
V
E
A
Q
L
--
A
-------
V
L
G
------
T
V
V
D
-
A
--
I
T
T
T
L
S
L
K
S
I
-
D
--
E
I
--------
A
Q
R
V
--
G
---
E
----------------
E
H
E
A
V
K
-----
E
L
R
Q
F
F
-------
E
Q
V
E
A
Y
G
Y
G
-
D
W
V
-
L
F
D
A
S
--
V
V
R
G
L
A
Y
Y
T
G
I
V
F
E
G
F
D
R
E
-----
G
---
K
F
R
A
L
C
G
G
G
R
Y
D
N
L
L
T
T
Y
-
G
S
---
P
T
P
I
P
C
A
G
F
G
F
G
D
C
V
I
V
E
L
L
---
Q
E
K
RLLP
D
I
-----
P
---
H
--
V
V
D
D
V
-
V
I
P
F
D
E
S
M
R
P
H
-
A
L
A
V
L
R
R
L
R
D
A
--
G
R
-------------------------------------------
10
PsiBlast_PDB
62.32
25%
-5
- C3 -
4YP0
7
?
A:
[26-401]
M
V
E
T
E
P
V
Q
G
C
R
D
F
P
P
-------
E
A
M
R
C
R
R
H
L
F
D
V
F
H
A
T
A
K
T
F
G
F
E
E
Y
D
A
P
V
L
E
-----
S
E
E
L
-
Y
I
R
---
K
--
A
G
E
E
I
T
E
Q
M
F
N
F
I
T
K
-
G
G
H
R
V
A
L
R
P
E
M
T
P
S
L
A
R
-
L
L
L
G
K
G
R
--
S
L
L
L
P
A
K
W
Y
S
I
P
Q
C
W
R
Y
E
-------
R
R
R
E
H
Y
Q
W
N
M
D
I
V
G
V
-
K
-
S
-
V
S
A
E
V
E
L
V
C
A
A
C
W
A
M
R
S
L
G
L
S
S
KD
V
G
I
K
V
N
S
R
K
V
L
Q
T
V
V
E
Q
A
G
V
T
S
---
D
K
F
A
P
V
C
V
I
V
D
K
-
M
E
K
I
P
R
E
E
---
V
E
A
Q
L
--
A
-------
V
L
G
L
---
E
P
T
V
V
D
-
A
--
I
T
T
T
L
S
L
K
S
I
-
D
--
E
I
--------
A
Q
R
V
--
G
---
E
----------------
E
H
E
A
V
K
-----
E
L
R
Q
F
F
-------
E
Q
V
E
A
Y
G
Y
G
-
D
W
V
-
L
F
D
A
S
--
V
V
R
G
L
A
Y
Y
T
G
I
V
F
E
G
F
D
R
E
-----
G
---
K
F
R
A
L
C
G
G
G
R
Y
D
N
L
L
T
T
Y
-
G
S
---
P
T
P
I
P
C
A
G
F
G
F
G
D
C
V
I
V
E
L
L
---
Q
E
K
RLLP
D
I
-----
P
---
H
--
V
V
D
D
V
-
V
I
P
F
D
E
S
M
R
P
H
-
A
L
A
V
L
R
R
L
R
D
A
--
G
R
-------------------------------------------
3
PsiBlast_PDB
61.87
29%
-0
- C3 -
1WU7
-
SYH_THEAC
A:
[4-311]
-
L
Q
I
E
K
I
R
G
F
R
D
F
Y
P
---
E
D
M
D
V
E
K
F
I
F
K
T
A
E
E
A
A
----
E
A
F
G
F
R
R
I
D
F
P
S
L
E
----
Y
L
D
L
Y
-
R
I
K
---
S
--
G
E
E
L
L-
Q
Q
T
Y
S
F
V
D
K
-
G
G
R
E
V
T
L
I
P
E
A
T
P
S
T
V
R
M
V
T
S
R
K
D
L
--
Q
R
--
P
L
R
W
Y
S
F
P
K
V
W
R
Y
E
E
P
--
Q
A
G
R
Y
R
E
H
Y
Q
F
N
A
D
I
F
G
S
-
D
-
S
-
P
E
A
D
A
E
V
I
A
L
A
S
S
I
L
D
R
L
G
L
Q
D
I-----------
Y
E
I
R
I
N
S
R
K
I
M
E
-------
E
I
I
G
G
M
T
S
-
S
D
P
F
S
V
F
S
---
I
I
D
R
Y
HK
I
S
R
E
E
F
--
V
D
Q
L
---
R
S
A
G
I
G
-
E
D
G
V
S
M
I
A
D
L
C
S
G
-
T
--
R
----------
G
I
D
--
E
---
M
---
A
R
I
-------
T
G
K
S
S
E
E
I
A
-----
R
M
A
A
V
E
-------
D
L
L
A
S
Y
G
V
--
K
N
V
-
R
Y
D
F
S
--
I
V
R
G
L
S
Y
Y
T
G
I
V
F
E
A
Y
D
R
S
-----
G
---
Q
F
R
A
I
L
G
G
G
R
Y
D
N
L
A
S
L
M
-
S
G
---
E
S
V
-
P
A
V
G
F
G
--------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
61.84
25%
-2
- C3 -
3LC0
1
?
A:
[26-401]
M
V
E
T
E
P
V
Q
G
C
R
D
F
P
P
-------
E
A
M
R
C
R
R
H
L
F
D
V
F
H
A
T
A
K
T
F
G
F
E
E
Y
D
A
P
V
L
E
-----
S
E
E
L
-
Y
I
R
---
K
--
A
G
E
E
I
T
E
Q
M
F
N
F
I
T
K
-
G
G
H
R
V
A
L
R
P
E
M
T
P
S
L
A
R
-
L
L
L
G
K
G
R
--
S
L
L
L
P
A
K
W
Y
S
I
P
Q
C
W
R
Y
E
A
-------
R
R
E
H
Y
Q
W
N
M
D
I
V
G
V
-
K
-
S
-
V
S
A
E
V
E
L
V
C
A
A
C
W
A
M
R
S
L
G
L
S
S
KD
V
G
I
K
V
N
S
R
K
V
L
Q
T
V
V
E
Q
A
G
V
T
S
---
D
K
F
A
P
V
C
V
I
V
D
K
-
M
E
K
I
P
R
E
E
---
V
E
A
Q
L
--
A
-------
V
L
G
L
---
E
P
T
V
V
D
-
A
--
I
T
T
T
L
S
L
K
S
I
-
D
--
E
I
--------
A
Q
R
V
--
G
---
E
----------------
E
H
E
A
V
K
-----
E
L
R
Q
F
F
-------
E
Q
V
E
A
Y
G
Y
G
-
D
W
V
-
L
F
D
A
S
--
V
V
R
G
L
A
Y
Y
T
G
I
V
F
E
G
F
D
R
E
-----
G
---
K
F
R
A
L
C
G
G
G
R
Y
D
N
L
L
T
T
Y
-
G
S
---
P
T
P
I
P
C
A
G
F
G
F
G
D
C
V
I
V
E
L
L
---
Q
E
K
RLLP
D
I
-----
P
---
H
--
V
V
D
D
V
-
V
I
P
F
D
E
S
M
R
P
H
-
A
L
A
V
L
R
R
L
R
D
A
--
G
R
-------------------------------------------
12
PsiBlast_PDB
61.78
25%
-4
- C3 -
4YRE
8
?
A:
[26-401]
M
V
E
T
E
P
V
Q
G
C
R
D
F
P
P
-------
E
A
M
R
C
R
R
H
L
F
D
V
F
H
A
T
A
K
T
F
G
F
E
E
Y
D
A
P
V
L
E
-----
S
E
E
L
-
Y
I
R
---
K
--
A
G
E
E
I
T
E
Q
M
F
N
F
I
T
K
-
G
G
H
R
V
A
L
R
P
E
M
T
P
S
L
A
R
-
L
L
L
G
K
G
R
--
S
L
L
L
P
A
K
W
Y
S
I
P
Q
C
W
R
Y
--------
R
R
R
E
H
Y
Q
W
N
M
D
I
V
G
V
-
K
-
S
-
V
S
A
E
V
E
L
V
C
A
A
C
W
A
M
R
S
L
G
L
S
S
KD
V
G
I
K
V
N
S
R
K
V
L
Q
T
V
V
E
Q
A
G
V
T
S
---
D
K
F
A
P
V
C
V
I
V
D
K
-
M
E
K
I
P
R
E
E
---
V
E
A
Q
L
--
A
-------
V
L
G
L
---
E
P
T
V
V
D
-
A
--
I
T
T
T
L
S
L
K
S
I
-
D
--
E
I
--------
A
Q
R
V
--
G
---
E
----------------
E
H
E
A
V
K
-----
E
L
R
Q
F
F
-------
E
Q
V
E
A
Y
G
Y
G
-
D
W
V
-
L
F
D
A
S
--
V
V
R
G
L
A
Y
Y
T
G
I
V
F
E
G
F
D
R
E
-----
G
---
K
F
R
A
L
C
G
G
G
R
Y
D
N
L
L
T
T
Y
-
G
S
---
P
T
P
I
P
C
A
G
F
G
F
G
D
C
V
I
V
E
L
L
---
Q
E
K
RLLP
D
I
-----
P
---
H
--
V
V
D
D
V
-
V
I
P
F
D
E
S
M
R
P
H
-
A
L
A
V
L
R
R
L
R
D
A
--
G
R
-------------------------------------------
17
PsiBlast_PDB
61.63
25%
-2
- C3 -
4YRO
9
?
A:
[26-401]
M
V
E
T
E
P
V
Q
G
C
R
D
F
P
P
-------
E
A
M
R
C
R
R
H
L
F
D
V
F
H
A
T
A
K
T
F
G
F
E
E
Y
D
A
P
V
L
E
-----
S
E
E
L
-
Y
I
R
---
K
--
A
G
E
E
I
T
E
Q
M
F
N
F
I
T
K
-
G
G
H
R
V
A
L
R
P
E
M
T
P
S
L
A
R
-
L
L
L
G
K
G
R
--
S
L
L
L
P
A
K
W
Y
S
I
P
Q
C
W
R
Y
E
-------
R
R
R
E
H
Y
Q
W
N
M
D
I
V
G
V
-
K
-
S
-
V
S
A
E
V
E
L
V
C
A
A
C
W
A
M
R
S
L
G
L
S
S
KD
V
G
I
K
V
N
S
R
K
V
L
Q
T
V
V
E
Q
A
G
V
T
S
---
D
K
F
A
P
V
C
V
I
V
D
K
-
M
E
K
I
P
R
E
E
---
V
E
A
Q
L
--
A
-------
V
L
G
L
---
E
P
T
V
V
D
-
A
--
I
T
T
T
L
S
L
K
S
I
-
D
--
E
I
--------
A
Q
R
V
--
G
---
E
----------------
E
H
E
A
V
K
-----
E
L
R
Q
F
F
-------
E
Q
V
E
A
Y
G
Y
G
-
D
W
V
-
L
F
D
A
S
--
V
V
R
G
L
A
Y
Y
T
G
I
V
F
E
G
F
D
R
E
-----
G
---
K
F
R
A
L
C
G
G
G
R
Y
D
N
L
L
T
T
Y
-
G
S
---
P
T
P
I
P
C
A
G
F
G
F
G
D
C
V
I
V
E
L
L
---
Q
E
K
RLLP
D
I
-----
P
---
H
--
V
V
D
D
V
-
V
I
P
F
D
E
S
M
R
P
H
-
A
L
A
V
L
R
R
L
R
D
A
--
G
R
-------------------------------------------
6
PsiBlast_PDB
61.62
27%
15
- C3 -
4E51
1
SYH_BURTA
A:
[37-420]
--------
G
M
N
D
I
L
P
QD
A
G
L
W
E
F
F
E
A
T
V
K
S
L
---
L
----
R
A
Y
G
Y
Q
N
I
R
T
P
I
V
E
H
T
P
L
F
T
R
G
I
-
G
E
V
---
T
--
D
I
V
E
--
K
E
M
Y
S
F
V
D
A
L
N
G
E
N
L
T
L
R
P
E
N
T
A
A
V
V
R
-
A
A
I
E
H
N
M
--
L
Y
D
G
P
K
R
L
W
Y
I
G
P
M
F
R
H
E
R
P
-----
R
Y
R
Q
F
H
Q
V
G
V
E
A
L
G
F
-
A
-
G
-
P
D
A
D
A
E
I
V
M
M
C
Q
R
L
W
E
D
L
G
L
T
G
------------
I
K
L
E
I
N
S
L
G
L
A
E
E
R
A
A
H
R
V
E
L
I
K
Y
L
E
Q
H
A
D
K
L
D
D
D
A
---
Q
R
R
L
Y
--
T
N
-------------
P
L
R
V
L
D
T
K
N
P
A
L
Q
-----------
E
I
--------
V
R
N
A
--
P
---
K
---
L
I
D
------------
F
L
G
D
-----
V
S
R
A
H
F
-------
E
G
L
Q
R
L
L
K
A
-
N
N
V
-
P
F
T
I
N
PR
L
V
R
G
L
D
Y
Y
N
L
T
V
F
E
W
V
T
D
K
-----------G
T
V
A
A
G
G
R
Y
D
P
L
I
E
Q
L
G
G
K
---
P
T
--
A
A
C
G
W
A
M
G
I
E
R
I
L
E
L
L
K
E
E
H
L
V
----
P
E
-----
Q
---
E
--
G
V
D
V
Y
-
V
--
V
H
Q
G
D
A
A
R
-
E
Q
A
F
I
V
A
E
R
L
R
D
T
G
L
D
V
I
L
H
CSA
D
G
-
A
--
G
A
S
-
F
K
S
Q
M
K
R
A
D
A
S
G
A
A
F
----------
16
PsiBlast_PDB
61.54
25%
-2
- C3 -
4YRN
8
?
A:
[26-401]
M
V
E
T
E
P
V
Q
G
C
R
D
F
P
P
-------
E
A
M
R
C
R
R
H
L
F
D
V
F
H
A
T
A
K
T
F
G
F
E
E
Y
D
A
P
V
L
E
-----
S
E
E
L
-
Y
I
R
---
K
--
A
G
E
E
I
T
E
Q
M
F
N
F
I
T
K
-
G
G
H
R
V
A
L
R
P
E
M
T
P
S
L
A
R
-
L
L
L
G
K
G
R
--
S
L
L
L
P
A
K
W
Y
S
I
P
Q
C
W
R
Y
E
A
I
--
T
R
--
R
R
E
H
Y
Q
W
N
M
D
I
V
G
V
-
K
-
S
-
V
S
A
E
V
E
L
V
C
A
A
C
W
A
M
R
S
L
G
L
S
S
KD
V
G
I
K
V
N
S
R
K
V
L
Q
T
V
V
E
Q
A
G
V
T
S
---
D
K
F
A
P
V
C
V
I
V
D
K
-
M
E
--
P
R
E
E
---
V
E
A
Q
L
--
A
-------
V
L
G
L
---
E
P
T
V
V
D
-
A
--
I
T
T
T
L
S
L
K
S
I
-
D
--
E
I
--------
A
Q
R
V
--
G
---
E
----------------
E
H
E
A
V
K
-----
E
L
R
Q
F
F
-------
E
Q
V
E
A
Y
G
Y
G
-
D
W
V
-
L
F
D
A
S
--
V
V
R
G
L
A
Y
Y
T
G
I
V
F
E
G
F
D
R
E
-----
G
---
K
F
R
A
L
C
G
G
G
R
Y
D
N
L
L
T
T
Y
-
G
S
---
P
T
P
I
P
C
A
G
F
G
F
G
D
C
V
I
V
E
L
L
---
Q
E
K
RLLP
D
I
-----
P
---
H
--
V
V
D
D
V
-
V
I
P
F
D
E
S
M
R
P
H
-
A
L
A
V
L
R
R
L
R
D
A
--
G
R
-------------------------------------------