@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu36280: (2016-07-31 )
MASLKEILIHVEQMEDGSFTLSAFDENEQPLPYSHMKKHLFQWHESSFYGTFLEDVSFIGTTAVLLSPWMTVELLGKNSFNSFSSVQLTEETEPLIEAASTIYEFIADGDFMPDYDAWTNGVFRWKDRDNILEGFTAEWFSAAVQDYIQYDDDLREKWEHIKEKSPAVTTFRGHFLDEEDFLEGIGWIDDQSPFTVGLRLNEPDFDGDEWKIEMFLRDKKSGAVEFFDGLKSLKKSWQAYSDKIAREQDRFHRTVPWLSFDSGTTLISEEEAWIFLSEASETLVDMGVEILLPSWWQIVRDSNMMLKAKVSSSPRGESFVGMNALLDFNWRFATNGIELTEAEFNELVASNRRLVNIRGQWVKIDPQFIKQMKRLMEKAESEGLHMSDILARELMDQQDGGLEDSDLIDTSAFAGIQFDLSKQLRSLIRKLTAAENLPEHKVSPSFKGTLRPYQKYGMNWLLFLRESGFGACLADDMGLGKTIQMIAYFLHVKESGRQKTPHLIIAPTSVLGNWQRELQTFAPDLSVALHYGPRRPKGDDFAAHYENADVVLTSYGLSHADTEELSSVTWNTICLDEAQNIKNAHTKQSRAIRKLKGLHHIALSGTPMENRLTELWSIFDFMNKGYLGSLTGFHKRYVLPIEKDRDEKRIGQLQQLIRPFLLRRTKRDEEVALNLPEKLEEKEFIPLSAEQASLYEQLVKDTFDHMTSLTGMQRKALILSMLGRLKQICDHPALYLKEEQTELLAGRSVKLEKLLELMTAIRAQNESCLIFTQYIQMGNMMKRLLEKTFGEPVQFLNGSLSKQERDTLVEKFQRKEYPTLILSLKAGGTGLNLTAANHVIHYDRWWNPAVENQATDRAYRIGQERFVHVHKMITTGTIEEKIDVMLESKQTLNDQIIQSENWITELSTQELEELFTLSATAQ
Atome Classification :
(20 SA)
-.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440-.......450.......460..-----.-----.-----...470.......480.......490.....------..500----.----.-....-.510...-....520.--.---.--....530.......-540.------....----------.--------.550.......560.-----.--.---....570.......580.--.---.--....590...---------....600.......610.......620.-------......-----------630.....----..640...-----------.-----------...650......------------------------------------.660-.....----------...670.......680.......690.......700..-------------------------....---.710.......720.......730--------..-.------------.----------------------.-.------------..-.740-----------------........-----.750.......760--.-....-----..770.......780.......790---.....--...800.......810.-..--.--.-.--.--820-........830.......840.......850......---.860.-.-.....870.......880.......890......-.-900.-......910.......920---------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-MA
S
L
K
E
I
L
I
H
V
EQMEDG
S
F
T
L
S
AFDENEQPL
P
Y
S
H
M
K
K
H
L
F
Q
W
H
ESS
F
Y
G
T
F
L
E
D
V
S
F
IG
T
T
A
V
L
LSP
W
M
T
V
E
L
LGKNSFNSFS
S
V
Q
LTEET
E
P
L
I
E
A
A
S
T
I
Y
E
F
IADGDFMP
D
Y
D
A
WTN
G
V
F
RWKDR
D
N
I
L
E
G
F
T
A
E
W
F
S
A
A
V
Q
D
Y
I
QY
D
D
D
L
R
E
K
W
E
H
I
K
EKSPA
V
T
T
F
RGHFL
D
E
E
D
F
L
E
G
IGWIDDQS
P
F
T
V
G
L
R
LNEPDFDGD
E
W
K
I
E
M
F
L
RDKKSG
A
V
E
F
F
D
G
L
K
S
L
K
K
S
W
Q
A
Y
S
D
K
I
A
R
E
Q
D
R
F
HRTVP
W
L
SFDSG
T
T
L
ISEE
E
A
W
I
F
L
S
E
A
S
E
T
L
V
D
M
G
V
E
I
L
L
P
S
W
W
Q
I
VRDSN
M
M
L
K
A
KVSSSPRGES
F
V
G
M
N
A
L
L
D
F
N
W
R
F
ATN
G
I
E
L
T
E
A
E
F
N
E
L
V
ASN
R
R
L
V
N
IRG
Q
W
V
KI
D
P
Q
F
I
K
Q
M
K
R
L
M
E
K
A
ESEGL
H
M
S
D
I
L
A
R
E
L
M
D
QQDGGLEDSDLIDTSAFA
G
I
Q
F
D
L
S
K
Q
L
R
S
L
I
R
K
L
T
A
AENLPEHKV-SPSFKGTL
R
P
Y
Q
K
YG
M
N
W
L
L
F
L
-----R-----E-----SGFG
A
C
L
ADDMGL
G
K
T
I
Q
M
I
A
Y
F
L
H
VKESGR------QKT
P
H
----
L
----
I
-
I
A
P
T
-
S
V
L
G
N
W
Q
-
R
E
L
Q
T
FAP--D---
L
--
S
V
A
L
HYGPRRPKGD-D
F
A
A------HYEN----------A--------
D
V
V
L
T
SYGLSHA
D
T
E
-----
E
--
L
---
S
SVTW
N
T
I
C
L
D
E
A
Q
N
I
K
N
--A---H--
T
K
Q
S
R
A
I
R
K
L
---------KG
L
H
H
I
ALSGT
P
M
E
N
R
L
T
E
L
W
S
I
F
D
F
M
N-------KGYLGS-----------LTGFH
K
R
Y
----
V
LPIEKD
R
-----------
D
-----------
E
K
R
I
G
Q
L
Q
Q
L
I
R
------------------------------------
P
F
L
--
L
R
RTK----------RDE
E
V
ALNL
P
E
KLEEKEFIPLS
A
E
Q
A
S
L
Y
E
Q
L
V
K
D
T
F
D
-------------------------
H
M
T
S
---
L
T
G
M
Q
R
K
A
L
I
L
S
M
L
G
R
L
K
Q
I
CD----------HP-
A
------------
L
----------------------
Y
-
L
------------
K
E
-
E
Q
-------------------
T
E
L
LAGRS-----
V
K
L
E
K
L
L
E
L
M
T
A
I
R--A-QNE
S
-----
C
L
I
F
T
Q
Y
I
Q
M
G
N
M
M
K
R
L
L
E
K
TFG
E
----
P
V
Q
F
L
--
N
GSLS
K
Q
E
R
D
T
L
V
E
K
F
Q
-RK--E--Y-
P
--
T
--
L
I
--
L
S
L
KAGGT
G
L
N
L
T
AAN
H
V
I
H
YDRWWNPAVENQAT
D
R
A
---
Y
RI
G
Q
-
E
-
R
F
V
H
V
H
K
M
ITTG
T
I
E
E
K
I
D
V
M
LESKQTL
N
D
Q
I
IQ-S-EN
W
I
-
T
EL
S
T
Q
E
L
E
E
L
F
TLSATAQ---------------------------------------------------------------------
30
HHSearch
87.30
48%
-86
- C2 -
1Z63
2
?
A:
[30-495]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
P
Y
N
I
K
A
N
L
R
P
Y
Q
I
K
G
F
S
W
M
R
F
M
-----
N
-----
K
-----
L
G
F
G
I
C
L
A
D
D
M
G
L
G
K
T
L
Q
T
I
A
V
F
S
D
A
K
K
E
N
-------
E
L
T
P
S
----
L
----
V
-
I
C
P
L
-
S
V
L
K
N
W
E
-
E
E
L
S
K
F
A
P
--
H
---
L
--
R
F
A
V
F
H
E
D
R
S
K
I
-------------
K
L
E
D
----------
Y
--------
D
I
I
L
T
T
Y
A
V
L
L
R
D
T
------
R
--
L
---
K
E
V
E
W
K
Y
I
V
I
D
E
A
Q
N
I
K
N
--
P
---
Q
--
T
K
I
F
K
A
V
K
E
L
---------
K
S
K
Y
R
I
A
L
T
G
T
P
I
E
N
K
V
D
D
L
W
S
I
M
T
F
L
N
-------
P
G
L
L
G
S
-----------
Y
S
E
F
K
S
K
F
----
A
T
P
I
K
K
G
------------
D
-----------
N
M
A
K
E
E
L
K
A
I
I
S
------------------------------------
P
F
I
--
L
R
R
T
K
----------
Y
D
K
A
I
I
N
D
L
P
D
K
I
E
T
N
V
Y
C
N
L
T
P
E
Q
A
A
M
Y
K
A
E
V
E
N
L
F
N
-------------------------
N
I
D
S
---
V
T
G
I
K
R
K
G
M
I
L
S
T
L
L
K
L
K
Q
I
V
D
----------
H
P
-
A
------------
L
----------------------
L
-
K
------------
G
G
-
E
Q
----------------------
S
V
R
R
S
-----
G
K
M
I
R
T
M
E
I
I
E
E
A
L
--
D
-
E
G
D
K
-----
I
A
I
F
T
Q
F
V
D
M
G
K
I
I
R
N
I
I
E
K
E
L
N
T
----
E
V
P
F
L
--
Y
G
E
L
S
K
K
E
R
D
D
I
I
S
K
F
Q
-
N
N
P-
S
--
V
-
K
--
F
--
I
V
--
L
S
V
K
A
G
-
F
G
I
N
L
T
S
A
N
R
V
I
H
F
D
R
W
W
N
P
---
D
Q
A
T
D
R
V
---
Y
R
I
G
Q
-
T
-
R
N
V
I
V
H
K
L
I
S
V
G
T
L
E
E
K
I
D
Q
L
L
A
F
K
R
S
L
F
K
D
I
I
S
S
G
-
D
S
W
I
-
T
E
L
S
T
E
E
L
R
K
V
I
E
L
--------------------------------------------------------------------------
2
PsiBlast_PDB
82.98
45%
-87
- C2 -
1Z63
2
?
A:
[33-497]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
K
A
N
L
R
P
Y
Q
I
K
G
F
S
W
M
R
F
M
-----
N
-----
K
-----
L
G
F
G
I
C
L
A
D
D
M
G
L
G
K
T
L
Q
T
I
A
V
F
S
D
A
K
K
E
N
-------
E
L
T
P
S
----
L
----
V
-
I
C
P
L
-
S
V
L
K
N
W
E
-
E
E
L
S
K
F
A
P
--
H
---
L
--
R
F
A
V
F
H
E
D
R
S
-------
K
I
------
K
L
E
D
----------
Y
--------
D
I
I
L
T
T
Y
A
V
L
L
R
D
T
R
--------
L
---
K
E
V
E
W
K
Y
I
V
I
D
E
A
Q
N
I
K
N
--
P
---
Q
--
T
K
I
F
K
A
V
K
E
L
---------
K
S
K
Y
R
I
A
L
T
G
T
P
I
E
N
K
V
D
D
L
W
S
I
M
T
F
L
N
-------
P
G
L
L
G
S
-----------
Y
S
E
F
K
S
K
F
----
A
T
P
I
K
K
G
------------
D
-----------
N
M
A
K
E
E
L
K
A
I
I
S
------------------------------------
P
F
I
--
L
R
R
T
K
----------
Y
D
K
A
I
I
N
D
L
P
D
K
I
E
T
N
V
Y
C
N
L
T
P
E
Q
A
A
M
Y
K
A
E
V
E
N
L
F
N
-------------------------
N
I
D
S
---
V
T
G
I
K
R
K
G
M
I
L
S
T
L
L
K
L
K
Q
I
V
D
----------
H
P
-
A
------------
L
----------------------
L
-
K
------------
G
G
-
E
Q
-------------------
S
V
R
R
S
G
K
M
-----
I
R
T
M
E
I
I
E
---
E
A
L
--
D
-
E
G
D
K
-----
I
A
I
F
T
Q
F
V
D
M
G
K
I
I
R
N
I
I
E
K
E
L
N
T
----
E
V
P
F
L
--
Y
G
E
L
S
K
K
E
R
D
D
I
I
S
K
F
Q
-
N
N
P-
S
--
V
-
K
--
F
--
I
V
--
L
S
V
K
A
G
-
F
G
I
N
L
T
S
A
N
R
V
I
H
F
D
R
W
W
N
P
---
D
Q
A
T
D
R
V
---
Y
R
I
G
Q
-
T
-
R
N
V
I
V
H
K
L
I
S
V
G
T
L
E
E
K
I
D
Q
L
L
A
F
K
R
S
L
F
K
D
I
I
S
-
S
G
D
S
W
I
-
T
E
L
S
T
E
E
L
R
K
V
I
E
L
S
V
------------------------------------------------------------------------
1
PsiBlast_PDB
82.85
46%
-77
- C2 -
1Z6A
11
?
A:
[33-497]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
K
A
N
L
R
P
Y
Q
I
K
G
F
S
W
M
R
F
M
-----
N
-----
K
-----
L
G
F
G
I
C
L
A
D
D
M
G
L
G
K
T
L
Q
T
I
A
V
F
S
D
A
K
K
E
N
-------
E
L
T
P
S
----
L
----
V
-
I
C
P
L
-
S
V
L
K
N
W
E
-
E
E
L
S
K
F
A
P
--
H
---
L
--
R
F
A
V
F
H
E
D
R
S
-------
K
I
------
K
L
E
D
----------
Y
--------
D
I
I
L
T
T
Y
A
V
L
L
R
D
T
R
--------
L
---
K
E
V
E
W
K
Y
I
V
I
D
E
A
Q
N
I
K
N
--
P
---
Q
--
T
K
I
F
K
A
V
K
E
L
---------
K
S
K
Y
R
I
A
L
T
G
T
P
I
E
N
K
V
D
D
L
W
S
I
M
T
F
L
N
-------
P
G
L
L
G
S
-----------
Y
S
E
F
K
S
K
F
----
A
T
P
I
K
K
G
------------
D
-----------
N
M
A
K
E
E
L
K
A
I
I
S
------------------------------------
P
F
I
--
L
R
R
T
K
----------
Y
D
K
A
I
I
N
D
L
P
D
K
I
E
T
N
V
Y
C
N
L
T
P
E
Q
A
A
M
Y
K
A
E
V
E
N
L
F
N
-------------------------
N
I
D
S
---
V
T
G
I
K
R
K
G
M
I
L
S
T
L
L
K
L
K
Q
I
V
D
----------
H
P
-
A
------------
L
----------------------
L
-
K
------------
G
G
-
E
Q
-------------------
S
---
V
R
R
S
-----
G
K
M
I
R
T
M
E
I
I
E
E
A
L
--
D
-
E
G
D
K
-----
I
A
I
F
T
Q
F
V
D
M
G
K
I
I
R
N
I
I
E
K
E
L
N
T
----
E
V
P
F
L
--
Y
G
E
L
S
K
K
E
R
D
D
I
I
S
K
F
Q
-
N
N
P-
S
--
V
-
K
--
F
--
I
V
--
L
S
V
K
A
G
G
F
G
I
N
L
T
S
A
N
R
V
I
H
F
D
R
W
W
-----
D
Q
A
T
D
R
V
---
Y
R
I
G
Q
-
T
-
R
N
V
I
V
H
K
L
I
S
V
G
T
L
E
E
K
I
D
Q
L
L
A
F
K
R
S
L
F
K
D
I
I
S
-
S
G
D
S
W
I
-
T
E
L
S
T
E
E
L
R
K
V
I
E
L
S
V
------------------------------------------------------------------------
21
Fugue
71.29
27%
13
- C2 -
1Z3I
10
?
X:
[1-644]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
R
R
A
G
V
R
K
A
L
H
D
P
F
E
D
G
A
L
V
L
Y
E
P
P
A
I
S
A
H
D
L
I
K
A
D
K
E
K
L
P
V
H
V
V
V
-
D
P
V
L
S
K
V
L
R
P
H
Q
R
E
G
V
K
F
L
W
D
C
VTGRR
I
-----
E
-----
N
S
Y
G
C
I
M
A
D
E
M
G
L
G
K
T
L
Q
C
I
T
L
I
W
T
L
L
K
Q
S
P
------
D
C
K
P
E
IDKV
I
----
V
-
V
S
P
S
-
S
L
V
R
N
W
Y
-
N
E
V
G
K
W
L
G
--
G
R--
V
--
Q
P
V
A
I
D
G
G
S
K
D
E
I
D
-
S
K
L
V
------
N
F
I
S
----------
Q
QGMRIPT-
P
I
L
I
I
S
Y
E
T
F
R
L
H
A
E
-----
V
--
L
---
H
K
G
K
V
G
L
V
I
C
D
E
G
H
R
L
K
N
--
S
---
D
--
N
Q
T
Y
L
A
L
N
S
M
---------
N
A
Q
R
R
V
L
I
S
G
T
P
I
Q
N
D
L
L
E
Y
F
S
L
V
H
F
V
N
-------
S
G
I
L
G
T
-----------
A
Q
E
F
K
K
R
F
----
E
I
P
I
L
K
G
R
-----------
D
ADASDKDRAAG
E
Q
K
L
Q
E
L
I
S
I
V
N
------------------------------------
R
C
L
--
I
R
R
T
------------
S
D
I
L
S
K
Y
L
P
V
K
I
E
Q
V
V
C
C
N
L
T
P
L
Q
K
E
L
Y
K
L
F
L
K
Q
A
K
P
-------------------------
V
E
S
L
---
Q
T
G
-
K
I
S
V
S
S
L
S
S
I
T
S
L
K
K
L
C
N
----------
H
P
-
A
------------
L
----------------------
I
-
Y
------------
E
K
-
C
L
TGEEGFDGALDLFPQNYST
K
A
V
E
P
Q
L
S
-----
G
K
M
L
V
L
D
Y
I
L
A
M
T
R
--
T
T
T
S
D
K
-----
V
V
L
V
S
N
Y
T
Q
T
L
D
L
F
E
K
L
C
R
N
R
-
R
Y
----
L
Y
V
R
L
--
D
G
T
M
S
I
K
K
R
A
K
I
V
E
R
F
N
-
N
P
--
S
--
S
-
P
--
E
FI
F
M
--
L
S
S
K
A
G
G
C
G
L
N
L
I
G
A
N
R
L
V
M
F
D
P
D
W
N
P
A
N
D
E
Q
A
M
A
R
V
---
W
R
D
G
Q
-
K
-
K
T
C
Y
I
Y
R
L
L
S
T
G
T
I
E
E
K
I
L
Q
R
Q
A
H
K
K
A
L
S
S
C
V
V
D
-
E
E
Q
D
V
E
-
R
H
F
S
L
G
E
L
R
E
L
F
S
L
N
E
K
T
L
SDTHDRFRCRRCVNGRQVRPPPDDSDCTCDLSNWHHCADKRGLRDPVLQASWDAAVSFVFHQRSHEDQR
22
Fugue
68.33
26%
37
- C2 -
3MWY
1
CHD1_YEAST
W:
[36-783]
D
F
H
G
I
D
I
V
I
N
H
R
L
K
T
S
K
T
V
P
D
L
N
N
C
K
E
N
---------
Y
E
F
L
I
K
W
T
D
E
S
H
----------------
L
H
N
T
W
E
T
Y
E
S
I
G
Q
--------
V
R
G
L
K
R
L
D
N
Y
C
K
Q
F
I
-------------------------------
I
E
D
Q
Q
V
R
L
D
P
Y
V
T
A
E
D
I
E
I
M
D
M
E
R
E
R
R
L
D
E
F
E
E
F
H
V
P
E
R
I
I
D
S
Q
R
A
S
L
E
--------
D
G
T
S
Q
L
Q
Y
L
V
K
W
R
R
L
N
Y
D
E
A
T
W
E
N
A
T
D
I
V
K
L
A
P
E
Q
V
K
H
F
Q
N
R
E
N
-
S
K
I
L
P
Q
Y
S
S
N
Y
T
S
Q
R
P
R
F
E
K
L
S
V
Q
P
P
F
I
K
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
L
R
D
F
Q
L
T
G
I
N
W
M
A
F
L
-----
W
-----
S
-----
K
G
D
N
G
I
L
A
D
E
M
G
L
G
K
T
V
Q
T
V
A
F
I
S
W
L
I
F
A
R
R
------
Q
N
G
P
H
----
I
----
I
-
V
V
P
L
-
S
T
M
P
A
W
L
-
D
T
F
E
K
W
A
P
--
D
---
L
--
N
C
I
C
Y
M
G
N
Q
--
K
S
R
-
D
T
I
R
------
E
Y
E
F
----------
Y
TNPKTMKF
N
V
L
L
T
T
Y
E
Y
I
L
K
D
R
A
-----
E
--
L
---
G
S
I
K
W
Q
F
M
A
V
D
E
A
H
R
L
K
N
--
A
---
E
--
S
S
L
Y
E
S
L
N
S
F
---------
K
V
A
N
R
M
L
I
T
G
T
P
L
Q
N
N
I
K
E
L
A
A
L
V
N
F
L
M
-------
P
G
R
F
N
Q
----------------------------
D
E
E
-----------
Q
-----------
E
E
Y
I
H
D
L
H
R
R
I
Q
------------------------------------
P
F
I
--
L
R
R
L
------------
K
K
D
V
E
K
S
L
P
S
K
T
E
R
I
L
R
V
E
L
S
D
V
Q
T
E
Y
Y
K
N
I
L
T
K
N
Y
---------------------------------------
S
F
S
L
L
N
I
M
N
E
L
K
K
A
S
N
----------
H
P
-
Y
------------
L
----------------------
F
-
D
NAEERVLQKFMT
R
E
-
N
V
-------------------
L
R
G
L
I
M
S
S
-----
G
K
M
V
L
L
D
Q
L
L
T
R
L
K
--
K
-
D
G
H
R
-----
V
L
I
F
S
Q
M
V
R
M
L
D
I
L
G
D
Y
L
S
I
K
-
G
I
----
N
F
Q
R
L
--
D
G
T
V
P
S
A
Q
R
R
I
S
I
D
H
F
N
-
S
P
--
D
--
S
-
N
DF
V
--
F
L
--
L
S
T
R
A
G
G
L
G
I
N
L
M
T
A
D
T
V
V
I
F
D
S
D
W
N
P
Q
A
D
L
Q
A
M
A
R
A
---
H
R
I
G
Q
-
K
-
N
H
V
M
V
Y
R
L
V
S
K
D
T
V
E
E
E
V
L
E
R
A
R
K
K
M
I
L
-
E
Y
N
E
P
-
N
-
A
G
E
L
-
S
A
I
L
K
F
G
A
G
N
M
F
T
A
T
D
N
Q
K
KLEDLNLDDVLNHAEDHVTTPDLGESHLGGEEFLKQFE-------------------------------
32
HHSearch
68.23
28%
9
- C2 -
1Z3I
8
?
X:
[44-573]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
V
V
V
-
D
P
V
L
S
K
V
L
R
P
H
Q
R
E
G
V
K
F
L
W
D
C
-----
V
-----
T
GRRIE
N
S
Y
G
C
I
M
A
D
E
M
G
L
G
K
T
L
Q
C
I
T
L
I
W
T
L
L
K
Q
S
P
DCKP--
E
I
D
K
V
----
I
----
V
-
V
S
P
S
-
S
L
V
R
N
W
Y
-
N
E
V
G
K
W
L
G
--
G
R--
V
--
Q
P
V
A
I
D
G
G
S
K
D
E
I
D
S
K
L
V
N
FISQQG
M
R
I
P
----------
T
--------
P
I
L
I
I
S
Y
E
T
F
R
L
H
A
E
-----
V
--
L
---
H
K
G
K
V
G
L
V
I
C
D
E
G
H
R
L
K
N
--
S
---
D
--
N
Q
T
Y
L
A
L
N
S
M
---------
N
A
Q
R
R
V
L
I
S
G
T
P
I
Q
N
D
L
L
E
Y
F
S
L
V
H
F
V
N
-------
S
G
I
L
G
T
-----------
A
Q
E
F
K
K
R
F
----
E
I
P
I
L
K
G
R
DADASDKDRAA
G
-----------
E
Q
K
L
Q
E
L
I
S
I
V
N
------------------------------------
R
C
L
--
I
R
R
T
S
----------
D
I
--
L
S
K
Y
L
P
V
K
I
E
Q
V
V
C
C
N
L
T
P
L
Q
K
E
L
Y
K
L
F
L
K
Q
A
K
P
-------------------------
V
E
S
L
---
Q
-
T
G
K
I
S
V
S
S
L
S
S
I
T
S
L
K
K
L
C
N
----------
H
P
-
A
------------
L
----------------------
I
-
Y
------------
E
K
-
C
L
TGEEGFDGALDLFPQNYST
K
A
V
E
P
Q
L
S
-----
G
K
M
L
V
L
D
Y
I
L
A
M
T
R
T-
T
-
T
S
D
K
-----
V
V
L
V
S
N
Y
T
Q
T
L
D
L
F
E
K
L
C
R
N
R
-
R
Y
----
L
Y
V
R
L
--
D
G
T
M
S
I
K
K
R
A
K
I
V
E
R
F
N
-
N
P
--
S
SP
E
-
F
--
I
--
F
M
--
L
S
S
K
A
G
G
C
G
L
N
L
I
G
A
N
R
L
V
M
F
D
P
D
W
N
P
A
N
D
E
Q
A
M
A
R
V
---
W
R
D
G
Q
-
K
-
K
T
C
Y
I
Y
R
L
L
S
T
G
T
I
E
E
K
I
L
Q
R
Q
A
H
K
K
A
L
S
S
C
V
V
D
E
E
-
Q
D
V
E
-
R
H
F
S
L
G
E
L
R
E
L
F
S
L
N
E
K
-----------------------------------------------------------------------
3
PsiBlast_PDB
62.85
27%
39
- C2 -
1Z3I
8
?
X:
[40-571]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
L
P
V
H
V
V
V
D
P
V
L
S
K
V
L
R
P
H
Q
R
E
G
V
K
F
L
W
D
C
-----
V
TGRRI
E
-----
N
S
Y
G
C
I
M
A
D
E
M
G
L
G
K
T
L
Q
C
I
T
L
I
W
T
L
L
K
Q
S
P
------
D
C
K
P
E
----
I
DKVI
V
-
V
S
P
S
-
S
L
V
R
N
W
Y
-
N
E
V
G
K
W
L
G
--
G
---
R
VQ
P
V
A
I
D
G
G
S
K
----
D
-
E
I
D
S
------
K
L
V
N
FISQQGMRIP
T
--------
P
I
L
I
I
S
Y
E
T
F
R
L
H
A
E
-----
V
--
L
---
H
K
G
K
V
G
L
V
I
C
D
E
G
H
R
L
K
N
--
S
---
D
--
N
Q
T
Y
L
A
L
N
S
M
---------
N
A
Q
R
R
V
L
I
S
G
T
P
I
Q
N
D
L
L
E
Y
F
S
L
V
H
F
V
N
-------
S
G
I
L
G
T
-----------
A
Q
E
F
K
K
R
F
----
E
I
P
I
L
K
G
R
-----------
D
ADASDKDRAAG
E
Q
K
L
Q
E
L
I
S
I
V
N
------------------------------------
R
C
L
--
I
R
R
T
------------
S
D
I
L
S
K
Y
L
P
V
K
I
E
Q
V
V
C
C
N
L
T
P
L
Q
K
E
L
Y
K
L
F
L
K
Q
A
-
K
-------------------------
P
V
E
S
---
L
Q
T
G
K
I
S
V
S
S
L
S
S
I
T
S
L
K
K
L
C
N
----------
H
P
-
A
------------
L
IYEKCLTGEEGFDGALDLFPQN
Y
-
S
------------
T
K
-
A
V
-------------------
E
P
Q
L
S
G
K
M
-----
L
V
L
D
Y
I
L
A
M
T
R
T
----
T
-
T
S
D
K
-----
V
V
L
V
S
N
Y
T
Q
T
L
D
L
F
E
K
L
C
R
N
R
R
Y
L
----
Y
V
R
-
L
--
D
G
T
M
S
I
K
K
R
A
K
I
V
E
R
F
N
-
N
P
--
S
--
S
-
P
--
E
--
F
I
FM
L
S
S
K
A
G
G
C
G
L
N
L
I
G
A
N
R
L
V
M
F
D
P
D
W
N
P
A
N
D
E
Q
A
M
A
R
V
---
W
R
D
G
Q
-
K
-
K
T
C
Y
I
Y
R
L
L
S
T
G
T
I
E
E
K
I
L
Q
R
Q
A
H
K
K
A
L
S
S
C
V
V
D
-
E
-
E
Q
D
V
E
R
H
F
S
L
G
E
L
R
E
L
F
S
L
N
-------------------------------------------------------------------------
35
HHSearch
51.81
18%
-14
- C2 -
3DMQ
1
RAPA_ECOLI
A:
[147-637]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
G
Q
R
T
S
L
I
P
H
Q
L
N
I
A
H
D
V
G
R
------------
R
-----
H
A
P
R
V
L
L
A
D
E
V
G
L
G
K
T
I
E
A
G
M
I
L
H
Q
Q
L
L
S
G
-------
A
A
E
R
V
----
L
----
I
-
I
V
P
E
-
T
L
Q
H
Q
W
L
-
V
E
M
L
R
R
F
N
------
L
--
R
F
A
L
F
D
D
E
R
Y
A
E
A
Q
H
D
A
Y
N
------
P
F
D
T
----------
E
--------
Q
L
V
I
C
S
L
D
F
A
R
R
S
K
Q
R
L
E
--
H
--
L
---
C
E
A
E
W
D
L
L
V
V
D
E
A
H
H
L
V
W
--
S
EDA
P
--
S
R
E
Y
Q
A
I
E
Q
L
A
E
-------
H
V
P
G
V
L
L
L
T
A
T
P
E
Q
L
G
M
E
S
H
F
A
R
L
R
L
L
D
-------
P
N
R
F
H
D
-----------
F
A
Q
F
V
E
E
Q
----
K
N
Y
C
P
V
A
D
A
VAMLLAGNKL
S
-----------
N
D
E
L
N
M
L
G
E
M
I
G
EQDIEPLLQAANSDSEDAQSA
R
Q
E
L
V
S
M
L
MDRHGTS
R
V
L
--
F
R
N
T
R
----------
N
---
G
V
K
G
F
P
K
R
E
L
H
T
I
K
L
P
L
P
T
Q
Y
Q
T
A
I
K
V
S
------------------------------------------
G
I
M
G
A
R
K
S
A
E
D
R
A
R
D
M
L
Y
----------
P
E
-
R
------------
I
----------------------
Y
-
Q
------------
E
F
E
G
D
-------------------
N
A
T
W
W
N
F
D
-----
P
R
V
E
W
L
M
G
Y
L
T
S
H
-----
R
S
Q
K
-----
V
L
V
I
C
A
K
A
A
T
A
L
Q
L
E
Q
V
L
R
E
R
E
G
I
----
R
A
A
V
F
--
H
E
G
M
S
I
I
E
R
D
R
A
A
A
W
F
A
-
E
E
DT
G
--
A
-
Q
--
V
--
L
L
---
C
S
E
I
G
S
E
G
R
N
F
Q
F
A
S
H
M
V
M
F
D
L
P
F
N
P
D
L
L
E
Q
R
I
G
R
L
---
D
R
I
G
Q
-
A
-
H
D
I
Q
I
H
V
P
Y
L
E
K
T
A
Q
S
V
L
V
R
W
Y
H
E
G
L
D
A
F
E
H
T
C
P
------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
47.58
25%
-164
- C2 -
2HJV
-
DBPA_BACSU
A:
[241-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
S
-----
C
I
I
F
C
R
T
K
E
H
V
N
Q
L
T
D
E
L
D
D
-
L
G
Y
----
P
C
D
K
I
--
H
G
G
M
I
Q
E
D
R
F
D
V
M
N
E
F
K
-
R
G
--
E
--
Y
-
R
--
Y
--
L
V
---
A
T
D
V
A
A
R
G
I
D
I
E
N
I
S
L
V
I
N
Y
D
------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Fugue
47.47
12%
-35
- C2 -
4A2Q
-
?
A:
[1-791]
---------------------------------
M
T
A
D
E
K
R
S
L
Q
C
Y
R
R
Y
I
E
R
S
--------------
L
N
P
V
Y
V
L
G
N
M
T
D
W
L
P
D
E
L
R
E
R
I
R
K
E
E
E
R
G
V
S
G
A
A
A
L
F
L
D
A
V
L
Q
L
E
-------------
A
R
G
W
F
R
G
M
L
D
A
M
L
A
A
G
Y
T
G
L
A
E
A
I
E
N
W
D
F
S
K
L
E
K
L
E
L
H
R
Q
L
L
K
R
I
E
A
T
M
----------------------------
L
E
V
D
P
V
A
L
I
P
Y
I
S
T
C
L
I
D
R
E
C
E
E
I
Q
Q
I
S
E
N
R
S
K
A
A
G
I
T
K
L
I
E
C
L
C
R
S
D
K
E
H
W
P
K
S
L
Q
L
A
L
D
T
T
G
Y
Y
R
A
S
E
L
W
-
D
K
A
R
S
Y
Q
I
E
L
A
Q
P
A
I
N
-----------
G
K
N
A
L
I
C
A
P
T
G
S
---
G
K
T
F
V
S
I
L
I
C
E
H
H
F
Q
N
M
P
A
G
--------------
R
K
A
K
V
V
F
L
----
A
T
K
V
P
V
Y
E
Q
Q
K
N
V
F
K
H
H
F
E
R
Q
G
Y
S
V
Q
G
I
S
G
----
E
S
V
E
K
V
I
E
D
S
D
I
I
V
V
T
-
P
Q
I
L
V
N
S
F
E
D
G
T
L
T
S
L
S
I
F
T
-----------------------------
L
M
I
F
-----
D
-----
E
-----------
C
H
N
T
T
G
N
H
P
Y
N
V
L
M
T
R
Y
L
E
Q
K
F
N
S
A
------
S
Q
L
P
Q
----
I
----
L
G
L
T
A
S
-
V
G
V
G
N
A
K
-
N
I
E
E
T
I
E
H
--
I
---
C
--
S
L
C
S
Y
L
D
I
Q
-----------------------------------------
A
I
S
T
V
R
E
N
I
Q
E
L
Q
-----
R
--
F
---
M
N
K
P
E
I
D
V
R
L
V
K
R
R
I
H
N
P
--
F
---
A
--
A
I
I
S
N
L
M
S
E
T
---------
E
A
L
M
R
T
I
D
F
G
T
Q
N
Y
E
H
W
I
V
V
T
Q
R
K
C
R
L
L
--------------------------
Q
L
E
D
K
E
----
E
E
S
R
I
C
R
A
-----------
L
-----------
F
I
C
T
E
H
L
R
K
Y
N
D
------------------------------------
A
L
I
--
I
S
E
D
A
----------
R
I
I
D
A
L
S
Y
L
T
E
F
F
T
N
V
K
N
G
P
Y
T
E
L
E
Q
H
L
T
A
K
F
Q
E
K
-------------------------------------------------------------------------------------------------------------------------
E
P
-
E
L
-------------------
I
A
L
S
K
D
E
T
-----
N
E
N
P
K
L
E
E
L
V
C
I
L
D
--
D
-
A
Y
R
Y
NPQ
T
R
T
L
L
F
A
K
T
R
A
L
V
S
A
L
K
K
C
M
E
------------------------
E
N
P
I
L
N
Y
I
K
-
P
G
--
V
--
L
-
D
--
N
--
R
L
--
L
I
A
T
S
V
V
Q
------
C
N
L
V
V
L
Y
E
Y
S
G
N
V
T
K
M
I
Q
V
G
S
K
C
---
I
L
V
T
-------------
S
K
T
E
V
V
E
N
E
K
C
N
R
Y
K
E
E
M
M
N
K
A
V
E
K
-
I
-
Q
K
W
D
-
E
E
T
F
A
K
K
I
H
N
L
Q
M
K
E
R
V
L
----------------------------------------------------------------------
41
HHSearch
45.65
17%
-3
- C2 -
2FWR
5
?
A:
[91-456]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
S
L
R
D
Y
Q
E
K
A
L
E
R
W
L
V
-------------------
D
K
R
G
C
I
V
L
P
T
G
S
G
K
T
H
V
A
M
A
A
I
N
E
L
------------
S
T
P
T
----
L
----
I
-
V
V
P
T
L
A
L
A
E
Q
W
K
-
E
R
L
G
I
F
G
E
--
E
---
Y
---
V
G
E
F
S
G
R
I
-----------------
K
E
L
----------
K
--------
P
L
T
V
S
T
Y
D
S
A
Y
V
N
A
E
-----
K
--
L
---
G
-
N
R
F
M
L
L
I
F
D
E
V
H
H
L
P
A
--
E
---
S
----
Y
V
Q
I
A
Q
M
S
---------
I
A
P
F
R
L
G
L
T
A
T
F
E
R
E
D
G
R
H
E
I
L
K
E
-
V
V
G
-------
G
K
------------------------------------------------------------------------------------------------------------
V
--
F
E
L
F
P
----------
D
S
-
L
A
G
K
H
L
A
K
Y
T
I
K
R
I
F
V
P
L
A
E
D
E
R
V
E
Y
E
K
R
E
K
V
Y
K
Q
-------------------------
F
L
R
A
---
R
G
------
I
T
L
R
R
A
E
D
F
N
K
I
V
M
----------
A
S
-
G
YDERAYE-----
A
----------------------
L
R
A
------------
W
E
-
E
A
-------------------
R
R
I
A
F
N
S
K
-----
N
K
I
R
K
L
R
E
I
L
E
R
----
H
-
R
K
D
K
-----
I
I
I
F
T
R
H
N
E
L
V
Y
R
I
S
K
V
F
L
----------
I
P
A
I
--
T
H
R
T
S
R
E
E
R
E
E
I
L
E
G
F
R
-
T
G
--
R
--
F
-
R
--
A
--
I
V
---
S
S
Q
V
L
D
E
G
I
D
V
P
D
A
N
V
G
V
I
M
S
G
S
G
S
A
R
E
Y
I
Q
R
L
G
R
I
---
L
R
P
S
K
-
G
K
K
E
A
V
L
Y
E
L
I
S
R
G
T
G
--------------------------------------------------------------------------------------------------------------------
23
Fugue
44.77
16%
21
- C2 -
1WP9
1
?
A:
[1-486]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
L
R
R
D
L
I
Q
P
R
I
Y
Q
E
V
I
Y
A
K
C
-----
K
-----
E
-----
T
N
C
L
I
V
L
P
T
--
G
L
G
K
T
L
I
A
M
M
I
A
E
Y
R
L
T
K
Y
G
------
G
K
--
V
----
L
----
M
-
L
A
P
T
-
K
P
L
V
L
Q
H
A
E
S
F
R
R
L
F
N
--
L
---
P
--
P
E
K
I
V
A
L
T
G
E
K
S
P
E
-
E
R
S
K
------
A
W
A
R
----------
A
--------
K
V
I
V
A
T
P
Q
T
I
E
N
D
L
L
-----
A
GR
I
---
S
L
E
D
V
S
L
I
V
F
D
E
A
H
R
A
V
G
NY
A
---
Y
--
V
F
I
A
R
E
Y
K
R
Q
A--------
K
N
P
L
V
I
G
L
T
A
S
P
-
G
S
T
P
E
K
I
M
E
V
I
N
N
L
G
-------
I
E
H
I
E
Y
R
S
ENSPDVRPY
V
K
G
I
R
F
E
W
----
V
R
V
D
L
P
E
I
-----------
Y
-----------
K
E
V
R
K
L
L
R
E
M
L
R
------------------------------------
D
A
L
--
K
P
L
A
E
T
GLLESSSPD
I
P
K
K
E
V
L
R
A
G
Q
I
I
N
E
E
M
A
K
G
N
H
D
L
R
G
L
L
L
Y
H
A
M
A
L
K
L
H
-------------------------
H
A
I
E
---
L
L
E
T
Q
G
L
S
A
L
R
A
Y
I
K
K
L
Y
E
E
A
K
A
GST
K
A
S
K
E
I
F
S
-
D
------------
K
----------------------
R
-
M
------------
K
K
-
A
I
-------------------
S
L
L
V
Q
A
K
E
I
GLDH
P
K
M
D
K
L
K
E
I
I
R
E
Q
L
--
Q
-
R
K
Q
N
S
K
---
I
I
V
F
T
N
Y
R
E
T
A
K
K
I
V
N
E
L
V
K
D
G
I
K
----
A
K
R
F
V
--
G
Q
A
S
K
Q
R
E
Q
K
L
I
L
D
E
F
A
-
R
G
--
E
--
F
-
N
--
V
--
L
V
--
A
T
-
S
V
G
E
E
G
L
D
V
P
E
V
D
L
V
V
F
Y
E
---
P
V
P
S
A
I
R
S
I
Q
R
R
---
G
R
T
G
R
-
H
-
M
P
G
R
V
I
I
L
M
A
K
G
T
R
D
E
A
Y
Y
W
S
S
R
-----------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
44.13
23%
-119
- C2 -
3DMQ
-
RAPA_ECOLI
A:
[490-609]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
E
W
L
M
G
Y
L
T
S
H
R
--
S
-
Q
--
K
-----
V
L
V
I
C
A
K
A
A
T
A
L
Q
L
E
Q
V
L
R
E
R
E
G
I
----
R
A
A
V
F
--
H
E
G
M
S
I
I
E
R
D
R
A
A
A
W
F
A
-
E
E
--
D
--
T
G
A
--
Q
--
V
L
--
L
C
S
E
I
G
S
E
G
R
N
F
Q
F
A
S
H
M
V
M
F
D
L
P
F
N
P
D
L
L
E
Q
R
I
G
R
L
---
D
R
I
G
Q
-
A
-
H
D
I
Q
I
H
----------------------------------------------------------------------------------------------------------------------------
52
HHSearch
43.59
16%
-13
- C2 -
4LJY
4
PRP5_YEAST
A:
[72-425]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
L
T
P
I
Q
S
Q
A
L
P
A
I
M
S
-------------------
G
R
D
V
I
G
I
S
K
T
G
S
G
K
T
I
S
Y
L
L
P
L
L
R
Q
V
K
A
Q
R
PLSKHE
T
G
P
M
G
----
L
----
I
-
L
A
P
T
R
E
L
A
L
Q
I
H
-
E
E
V
T
K
F
T
E
--
A
DTS
I
--
R
S
V
C
C
T
G
G
S
E
M
K
K
--
Q
I
T
D
------
L
K
R
G
----------
T
--------
E
I
V
V
A
T
P
G
R
F
I
D
I
L
T
LNDGK
L
--
L
---
S
T
K
R
I
T
F
V
V
M
D
E
A
D
R
L
F
D
--
L
---
G
F
E
P
Q
I
T
Q
I
M
K
T
V
R--------
P
D
K
Q
C
V
L
F
S
A
T
F
P
N
K
L
R
S
F
A
V
R
V
L
H
S
----------
P
I
------------------------------
S
I
---------------------------------------------------------------------------
T
--
I
N
S
K
G
----------
M
---
V
N
---
E
N
V
K
Q
K
F
R
I
C
H
S
-
E
D
--
E
K
F
D
N
------------------------------------------------
L
V
Q
L
I
H
E
R
S
E
F
------------------------------------------------------------------------------------------------
F
D
-----
E
V
Q
S
---------------
D
A
K
-----
A
I
I
F
V
S
S
Q
N
I
C
D
F
I
S
K
K
L
L
N
A
-
G
I
----
V
T
C
A
I
--
H
A
G
K
P
Y
Q
E
R
L
M
N
L
E
K
F
K
-
R
E
--
K
--
N
-
S
--
I
--
L
L
---
C
T
E
V
L
S
R
G
L
N
V
P
E
V
S
L
V
I
I
Y
N
A
V
K
T
F
A
Q
Y
V
H
T
T
G
R
T
---
A
R
G
S
R
-
S
-
G
T
A
I
T
L
L
L
--------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
43.38
29%
-138
- C2 -
3PEV
2
A:
[38-134]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
-
K
S
E
G
H
----
E
V
S
I
L
--
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
--
R
E
--
G
--
R
-
S
--
K
--
V
L
--
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
---
P
T
L
A
N
G
Q
A
D
P
A
T
Y
I
H
R
I
G
R
-------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
42.06
14%
-23
- C2 -
2OCA
-
UVSW_BPT4
A:
[109-467]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
R
I
E
P
H
W
Y
Q
K
D
A
V
F
E
G
L
V
-------------------
N
R
R
R
I
L
N
L
P
T
S
A
G
R
S
L
I
Q
A
L
L
A
R
Y
Y
L
E
N
--------
Y
E
G
K
I
----
L
----
I
-
I
V
P
T
T
A
L
T
T
Q
M
A
-
D
D
F
V
D
Y
R
L
--
F
SH-
A
--
M
I
K
K
I
G
G
G
A
S
K
D
D
-----
K
------
Y
K
N
D
----------
A
--------
P
V
V
V
G
T
W
Q
T
V
V
K
Q
P
K
-----
E
--
W
----
F
S
Q
F
G
M
M
M
N
D
E
C
H
L
A
T
G
---------
K
S
I
S
S
I
I
S
G
L
N--------
N
C
M
F
K
F
G
L
S
G
S
L
-
R
D
G
K
A
N
I
M
Q
Y
V
G
M
F
G
-------
E
I
F
K
P
V
-----------
T
--------------
T
----------------------------------
S
----------------------------------------------------------------------
E
L
K
I
N
S
I
F
L
R
Y
P
D
E
F
T
T
K
L
K
---
G
K
-------------------------------------------
T
Y
Q
E
---
E
I
K
I
I
----------------------------------------------------------------------------------------------
T
G
L
S
-----
K
R
N
K
W
I
A
K
L
A
I
K
L
A
--
Q
-
K
D
E
N
-----
A
F
V
M
F
K
H
V
S
H
G
K
A
I
F
D
L
I
K
N
E
-
Y
D
----
K
V
Y
Y
V
--
S
G
E
V
D
T
E
T
R
N
-
I
M
K
T
L
A
E
N
G
--
K
--
G
-
I
--
I
--
I
V
--
A
S
Y
G
V
F
S
T
G
I
S
V
K
N
L
H
H
V
V
L
A
H
G
V
K
S
K
I
I
V
L
Q
T
I
G
R
V
---
L
R
K
H
G
S
K
-
T
I
A
T
V
W
D
L
I
D
D
A
G
V
K
P
K
S
A
N
T
-------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
42.06
29%
-136
- C2 -
3RRM
1
DBP5_YEAST
A:
[245-339]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
-
K
S
E
G
H
----
E
V
S
I
L
--
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
--
R
E
--
G
--
R
-
S
--
K
--
V
L
--
I
T
T
N
------
D
I
P
T
V
S
M
V
V
N
Y
D
L
---
P
T
L
A
N
G
Q
A
D
P
A
T
Y
I
H
R
I
G
R
-------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
41.97
29%
-131
- C2 -
3PEU
2
A:
[38-134]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
-
K
S
E
G
H
----
E
V
S
I
L
--
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
--
R
E
--
G
--
R
-
S
--
K
--
V
L
--
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
---
P
T
L
A
N
G
Q
A
D
P
A
T
Y
I
H
R
I
G
R
-------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
41.38
29%
-141
- C2 -
5ELX
3
?
A:
[242-336]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
-
K
S
E
G
H
----
E
V
S
I
L
--
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
--
R
E
--
G
--
R
-
S
--
K
--
V
L
--
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
---
P
T
L
A
N
G
Q
A
D
P
A
T
Y
I
H
R
I
G
R
-------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
41.08
15%
9
- C2 -
3TBK
2
DDX58_MOUSE
A:
[3-529]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
P
R
N
Y
Q
L
E
L
A
L
P
A
K
K
-------------------
G
K
N
T
I
I
C
A
P
T
G
C
G
K
T
F
V
S
L
L
I
C
E
H
H
L
K
K
F
P
CG----
Q
K
G
K
V
----
V
----
F
-
F
A
N
Q
I
P
V
Y
E
Q
Q
A
-
T
V
F
S
R
Y
F
E
RL
G
---
Y
--
N
I
A
S
I
S
G
A
T
S
D
S
V
--
S
V
Q
H
------
I
I
E
D
----------
N
--------
D
I
I
I
L
T
P
Q
I
L
V
N
N
L
N
-----
N
--
G
AIP
S
L
S
V
F
T
L
M
I
F
D
E
C
H
N
T
S
K
--
N
---
H
--
P
Y
N
Q
I
M
F
R
Y
L
D
H
K
L
GESR
D
P
L
P
Q
V
V
G
L
T
A
S
V
G
V
G
D
A
K
T
A
E
E
A
M
Q
H
I
C
K
L
C
A
A
L
D
A
S
V
I
A
T
-----------
V
R
D
N
V
A
E
L
E
Q
V
V
Y
K
P
Q
K
I
S
R
K
V
---------
A
-----------
S
R
T
S
N
T
F
K
C
I
I
S
------------------------------------
Q
L
M
K
E
T
E
K
L
A
----------
K
D
--
V
S
E
E
L
G
K
L
F
-
Q
I
Q
---
N
R
E
F
G
T
Q
K
Y
E
Q
W
I
V
G
V
H
K
A
C
S
V
FQMAD
K
E
E
E
S
R
V
C
K
A
L
F
L
Y
T
S
H
L
R
K
Y
N
D
A
L
I
I
S
E
D
A
Q
M
T
D
A
L
N
Y
L
K
A
F
F
H
----------
D
V
R
E
T
E
R
E
L
T
R
R
F
E
E
K
L
----------------------
E
-
E
------------
L
E
-
K
V
-------------------
S
R
D
P
S
N
E
N
-----
P
K
L
R
D
L
Y
L
V
L
Q
E
E
Y
H
L
K
-
P
E
T
K
-----
T
I
L
F
V
K
T
R
A
L
V
D
A
L
K
K
W
I
E
E
N
-
P
A
LSFL
K
P
G
I
L
TG----------------------
D
--
N
-
N
--
I
--
L
I
---
A
T
S
V
A
D
E
G
I
D
I
A
E
C
N
L
V
I
L
Y
E
Y
V
G
N
V
I
K
M
I
Q
T
R
G
R
----
G
R
A
R
-----
D
S
K
C
F
L
L
T
S
S
A
D
V
I
E
K
E
K
A
N
M
I
K
E
K
I
M
N
E
S
I
L
R
------------------------------------------------------------------------------------------------