@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu37170: (2016-08-01 )
MNFSLSEEHEMIRKLVRDFAKHEVAPTAAERDEQERFDRELFREMANLGLTGIPWPEDYGGIGSDYLAYVIAVEELSKVCASTGVTLSAHISLCSWPLFAFGTEEQKTEYLTQLALGEKIGAFALTEAGSGSDAGSMKTTAERIGDDYVLNGSKVFITNGGVADIYIVFAVTDPEKKKKGVTAFIVEKDFEGFFTGKKEKKLGIRSSPTTEIMFEDCVVPASKRLGEEGEGFKIAMKTLDGGRNGIAAQAVGIAQGALDAALQYAKERKQFGKSIAEQQGIAFKLADMATMIEASRLLTYQAAWLESSGLPYGKASAMSKLMAGDTAMKVTTEAVQIFGGYGYTKDYPVERYMRDAKITQIYEGTQEIQRLVISRMLAD
Atome Classification :
(37 SA)
.........10........20........30......-..40........50........60...---.---.---...70........80........90........100.......110.......120.......130.......140.--.-..-...150.......160.......170..----.----..---..180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNFSL
S
E
E
H
E
M
I
R
K
L
V
R
D
F
A
KHEVAPTAAE
R
D
E
Q
E
R
F
-
D
R
E
L
F
R
E
M
A
NLGLTGIPWPEDYGGI
G
S
---
D
---
Y
---
L
A
Y
V
I
A
V
E
E
L
S
K
V
C
A
STG
V
T
L
S
A
H
I
S
LCSW
P
L
F
AFGT
E
E
Q
K
T
E
Y
L
T
Q
L
ALGEKI
G
A
F
A
L
TEAGSGSDAGS
M
K
T
T
A
E
R--I-GD-
D
Y
V
LNG
S
K
V
F
I
TNGG
V
A
D
I
Y
I
V
F
A
VT
D
P
----
E
----
K
K---KKG
V
T
A
F
I
V
EKDF
E
G
FFTGK
K
E
KKLGIRSSPT
T
E
I
M
FEDCVV
P
A
S
K
RLGEEGE
G
F
K
I
A
M
K
TLDGGRNGI
A
A
Q
A
V
G
I
A
Q
G
A
L
D
A
A
L
Q
Y
A
K
E
R
K
Q
F
G
K
S
I
A
E
QQG
I
A
F
K
L
A
D
M
A
T
M
I
E
A
S
R
L
L
T
Y
Q
A
A
W
L
ESSGLPY
G
K
A
S
A
M
S
K
L
MAGD
T
A
M
K
V
T
T
E
A
V
Q
I
FGGYGYTKDY
P
V
E
R
Y
M
R
D
A
K
I
T
Q
I
Y
E
G
T
Q
E
I
Q
R
L
V
I
S
R
MLAD
23
PsiBlast_CBE
89.70
50%
-74
- C1 -
1JQI
4
ACADS_RAT
B:
[10-382]
----
L
P
E
T
H
Q
M
L
R
Q
T
C
R
D
F
A
E
K
E
L
V
P
I
A
A
Q
L
D
K
E
H
L
F
-
P
T
S
Q
V
K
K
M
G
E
L
G
L
L
A
M
D
V
P
E
E
L
S
G
A
G
L
---
D
---
Y
---
L
A
Y
S
I
A
L
E
E
I
S
R
G
C
A
S
T
G
V
I
M
S
V
N
N
S
L
Y
L
G
P
I
L
K
F
G
S
S
Q
Q
K
Q
Q
W
I
T
P
F
T
N
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
R
E
--
E
-
G
D
-
S
W
V
L
N
G
T
K
A
W
I
T
N
S
W
E
A
S
A
T
V
V
F
A
S
T
D
R
----
S
----
R
Q
---
N
K
G
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
A
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
E
N
L
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
A
S
L
D
C
A
V
K
Y
A
E
N
R
H
A
F
G
A
P
L
T
K
L
Q
N
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
N
K
K
P
F
T
K
E
S
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
Y
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
G
H
L
--
21
PsiBlast_CBE
88.95
57%
-74
- C1 -
4L1F
5
?
B:
[1-377]
M
D
F
N
L
T
E
D
Q
Q
M
I
K
D
M
A
A
E
F
A
E
K
F
L
A
P
T
V
E
E
R
D
K
A
H
I
W
-
D
R
K
L
I
D
K
M
G
E
A
G
F
C
G
I
C
F
P
E
E
Y
G
G
M
G
L
---
D
---
V
---
L
S
Y
I
L
A
V
E
E
L
S
K
V
D
D
G
T
G
I
T
L
S
A
N
V
S
L
C
A
T
P
I
Y
M
F
G
T
E
E
Q
K
Q
K
Y
L
A
P
I
A
E
G
T
H
V
G
A
F
G
L
T
E
P
S
A
G
T
D
A
S
A
Q
Q
T
T
A
V
L
--
K
-
G
D
-
K
Y
I
L
N
G
S
K
I
F
I
T
N
G
K
E
A
D
T
Y
V
V
F
A
M
T
D
K
----
S
----
Q
G
---
V
H
G
I
S
A
F
I
L
E
K
G
M
P
G
F
R
F
G
K
I
E
D
K
M
G
G
H
T
S
I
T
A
E
L
I
F
E
D
C
E
V
P
K
E
N
L
L
G
K
E
G
E
G
F
K
I
A
M
E
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
G
A
L
A
A
A
V
K
Y
S
K
E
R
E
Q
F
G
R
S
I
S
K
F
Q
A
L
Q
F
M
M
A
D
M
A
T
K
I
E
A
A
R
Y
L
V
Y
H
A
A
M
L
K
N
E
G
K
P
Y
S
E
A
A
A
M
A
K
C
F
A
S
D
V
A
M
E
V
T
T
D
A
V
Q
I
F
G
G
Y
G
Y
T
V
D
Y
P
A
E
R
Y
M
R
N
A
K
I
T
Q
I
Y
E
G
T
N
Q
V
M
R
I
V
T
S
R
A
L
--
117
HHSearch
88.74
57%
-74
- C1 -
4L1F
7
?
A:
[1-379]
M
D
F
N
L
T
E
D
Q
Q
M
I
K
D
M
A
A
E
F
A
E
K
F
L
A
P
T
V
E
E
R
D
K
A
H
I
W
-
D
R
K
L
I
D
K
M
G
E
A
G
F
C
G
I
C
F
P
E
E
Y
G
G
M
G
L
---
D
---
V
---
L
S
Y
I
L
A
V
E
E
L
S
K
V
D
D
G
T
G
I
T
L
S
A
N
V
S
L
C
A
T
P
I
Y
M
F
G
T
E
E
Q
K
Q
K
Y
L
A
P
I
A
E
G
T
H
V
G
A
F
G
L
T
E
P
S
A
G
T
D
A
S
A
Q
Q
T
T
A
V
L
--
K
-
G
D
-
K
Y
I
L
N
G
S
K
I
F
I
T
N
G
K
E
A
D
T
Y
V
V
F
A
M
T
D
K
----
S
----
Q
G
---
V
H
G
I
S
A
F
I
L
E
K
G
M
P
G
F
R
F
G
K
I
E
D
K
M
G
G
H
T
S
I
T
A
E
L
I
F
E
D
C
E
V
P
K
E
N
L
L
G
K
E
G
E
G
F
K
I
A
M
E
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
G
A
L
A
A
A
V
K
Y
S
K
E
R
E
Q
F
G
R
S
I
S
K
F
Q
A
L
Q
F
M
M
A
D
M
A
T
K
I
E
A
A
R
Y
L
V
Y
H
A
A
M
L
K
N
E
G
K
P
Y
S
E
A
A
A
M
A
K
C
F
A
S
D
V
A
M
E
V
T
T
D
A
V
Q
I
F
G
G
Y
G
Y
T
V
D
Y
P
A
E
R
Y
M
R
N
A
K
I
T
Q
I
Y
E
G
T
N
Q
V
M
R
I
V
T
S
R
A
L
L
R
1
PsiBlast_PDB
88.56
57%
-74
- C1 -
4L1F
7
?
A:
[1-377]
M
D
F
N
L
T
E
D
Q
Q
M
I
K
D
M
A
A
E
F
A
E
K
F
L
A
P
T
V
E
E
R
D
K
A
H
I
W
-
D
R
K
L
I
D
K
M
G
E
A
G
F
C
G
I
C
F
P
E
E
Y
G
G
M
G
L
---
D
---
V
---
L
S
Y
I
L
A
V
E
E
L
S
K
V
D
D
G
T
G
I
T
L
S
A
N
V
S
L
C
A
T
P
I
Y
M
F
G
T
E
E
Q
K
Q
K
Y
L
A
P
I
A
E
G
T
H
V
G
A
F
G
L
T
E
P
S
A
G
T
D
A
S
A
Q
Q
T
T
A
V
L
--
K
-
G
D
-
K
Y
I
L
N
G
S
K
I
F
I
T
N
G
K
E
A
D
T
Y
V
V
F
A
M
T
D
K
----
S
----
Q
G
---
V
H
G
I
S
A
F
I
L
E
K
G
M
P
G
F
R
F
G
K
I
E
D
K
M
G
G
H
T
S
I
T
A
E
L
I
F
E
D
C
E
V
P
K
E
N
L
L
G
K
E
G
E
G
F
K
I
A
M
E
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
G
A
L
A
A
A
V
K
Y
S
K
E
R
E
Q
F
G
R
S
I
S
K
F
Q
A
L
Q
F
M
M
A
D
M
A
T
K
I
E
A
A
R
Y
L
V
Y
H
A
A
M
L
K
N
E
G
K
P
Y
S
E
A
A
A
M
A
K
C
F
A
S
D
V
A
M
E
V
T
T
D
A
V
Q
I
F
G
G
Y
G
Y
T
V
D
Y
P
A
E
R
Y
M
R
N
A
K
I
T
Q
I
Y
E
G
T
N
Q
V
M
R
I
V
T
S
R
A
L
--
3
PsiBlast_PDB
87.77
50%
-71
- C1 -
1JQI
4
ACADS_RAT
A:
[10-382]
----
L
P
E
T
H
Q
M
L
R
Q
T
C
R
D
F
A
E
K
E
L
V
P
I
A
A
Q
L
D
K
E
H
L
F
-
P
T
S
Q
V
K
K
M
G
E
L
G
L
L
A
M
D
V
P
E
E
L
S
G
A
G
L
---
D
---
Y
---
L
A
Y
S
I
A
L
E
E
I
S
R
G
C
A
S
T
G
V
I
M
S
V
N
N
S
L
Y
L
G
P
I
L
K
F
G
S
S
Q
Q
K
Q
Q
W
I
T
P
F
T
N
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
R
E
--
E
-
G
D
-
S
W
V
L
N
G
T
K
A
W
I
T
N
S
W
E
A
S
A
T
V
V
F
A
S
T
D
R
----
S
----
R
Q
---
N
K
G
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
A
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
E
N
L
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
A
S
L
D
C
A
V
K
Y
A
E
N
R
H
A
F
G
A
P
L
T
K
L
Q
N
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
N
K
K
P
F
T
K
E
S
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
Y
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
G
H
L
--
5
PsiBlast_PDB
86.64
50%
-78
- C1 -
2VIG
5
ACADS_HUMAN
A:
[6-378]
----
L
P
E
T
H
Q
M
L
L
Q
T
C
R
D
F
A
E
K
E
L
F
P
I
A
A
Q
V
D
K
E
H
L
F
-
P
A
A
Q
V
K
K
M
G
G
L
G
L
L
A
M
D
V
P
E
E
L
G
G
A
G
L
---
D
---
Y
---
L
A
Y
A
I
A
M
E
E
I
S
R
G
C
A
S
T
G
V
I
M
S
V
N
N
S
L
Y
L
G
P
I
L
K
F
G
S
K
E
Q
K
Q
A
W
V
T
P
F
T
S
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
R
A
--
E
-
G
D
-
S
W
V
L
N
G
T
K
A
W
I
T
N
A
W
E
A
S
A
A
V
V
F
A
S
T
D
R
----
A
----
L
Q
---
N
K
S
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
G
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
D
S
I
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
T
A
L
D
C
A
V
N
Y
A
E
N
R
M
A
F
G
A
P
L
T
K
L
Q
V
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
N
K
K
P
F
I
K
E
A
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
H
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
G
H
L
--
31
PsiBlast_CBE
85.89
50%
-79
- C1 -
2VIG
6
ACADS_HUMAN
D:
[6-378]
----
L
P
E
T
H
Q
M
L
L
Q
T
C
R
D
F
A
E
K
E
L
F
P
I
A
A
Q
V
D
K
E
H
L
F
-
P
A
A
Q
V
K
K
M
G
G
L
G
L
L
A
M
D
V
P
E
E
L
G
G
A
G
L
---
D
---
Y
---
L
A
Y
A
I
A
M
E
E
I
S
R
G
C
A
S
T
G
V
I
M
S
V
N
N
S
L
Y
L
G
P
I
L
K
F
G
S
K
E
Q
K
Q
A
W
V
T
P
F
T
S
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
R
A
--
E
-
G
D
-
S
W
V
L
N
G
T
K
A
W
I
T
N
A
W
E
A
S
A
A
V
V
F
A
S
T
D
----------------
K
S
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
G
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
D
S
I
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
T
A
L
D
C
A
V
N
Y
A
E
N
R
M
A
F
G
A
P
L
T
K
L
Q
V
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
N
K
K
P
F
I
K
E
A
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
H
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
G
H
L
--
32
PsiBlast_CBE
85.83
50%
-80
- C1 -
2VIG
5
ACADS_HUMAN
C:
[6-378]
----
L
P
E
T
H
Q
M
L
L
Q
T
C
R
D
F
A
E
K
E
L
F
P
I
A
A
Q
V
D
K
E
H
L
F
-
P
A
A
Q
V
K
K
M
G
G
L
G
L
L
A
M
D
V
P
E
E
L
G
G
A
G
L
---
D
---
Y
---
L
A
Y
A
I
A
M
E
E
I
S
R
G
C
A
S
T
G
V
I
M
S
V
N
N
S
L
Y
L
G
P
I
L
K
F
G
S
K
E
Q
K
Q
A
W
V
T
P
F
T
S
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
R
A
--
E
-
G
D
-
S
W
V
L
N
G
T
K
A
W
I
T
N
A
W
E
A
S
A
A
V
V
F
A
S
T
D
-----------------
S
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
G
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
D
S
I
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
T
A
L
D
C
A
V
N
Y
A
E
N
R
M
A
F
G
A
P
L
T
K
L
Q
V
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
N
K
K
P
F
I
K
E
A
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
H
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
G
H
L
--
40
PsiBlast_CBE
85.82
47%
-75
- C1 -
1UKW
3
?
B:
[1-376]
I
D
F
S
L
T
E
E
Q
R
Q
L
Q
A
L
A
R
R
F
A
K
E
V
I
L
P
V
A
Q
E
Y
D
E
K
E
E
V
-
P
W
P
V
I
E
K
L
H
E
V
G
L
L
N
A
I
I
P
E
E
Y
G
G
M
G
L
---
K
---
M
---
L
D
E
V
I
V
G
E
E
L
A
Y
A
C
M
G
I
-
Y
T
I
P
M
A
S
D
L
G
I
T
P
V
L
L
A
G
T
E
E
Q
K
E
R
F
L
R
P
L
T
E
K
P
A
L
A
A
F
A
L
S
E
P
G
N
G
S
D
A
A
A
L
K
T
R
A
I
R
--
Q
-
G
D
-
H
Y
V
L
N
G
T
K
M
W
I
S
N
G
G
E
A
E
W
V
V
V
F
A
T
V
N
P
----
E
----
L
R
---
H
K
G
V
V
A
L
V
V
E
R
G
T
P
G
F
K
A
I
K
I
H
G
K
M
G
Q
R
A
S
G
T
Y
E
L
V
F
E
D
V
K
V
P
V
E
N
R
L
G
E
E
G
E
G
F
K
I
A
M
Q
T
L
N
K
T
R
I
P
V
A
A
G
S
V
G
V
A
R
R
A
L
D
E
A
R
K
Y
A
K
E
R
E
A
F
G
E
P
I
A
N
F
Q
A
I
Q
F
K
L
V
D
M
L
I
G
I
E
T
A
R
M
Y
T
Y
Y
A
A
W
L
A
D
Q
G
L
P
H
A
H
A
S
A
I
A
K
A
Y
A
S
E
I
A
F
E
A
A
N
Q
A
I
Q
I
H
G
G
Y
G
Y
V
R
E
F
P
V
E
K
L
L
R
D
V
K
L
N
Q
I
Y
E
G
T
N
E
I
Q
R
L
I
I
A
R
H
I
--
29
PsiBlast_CBE
85.71
50%
-79
- C1 -
2VIG
9
ACADS_HUMAN
F:
[6-378]
----
L
P
E
T
H
Q
M
L
L
Q
T
C
R
D
F
A
E
K
E
L
F
P
I
A
A
Q
V
D
K
E
H
L
F
-
P
A
A
Q
V
K
K
M
G
G
L
G
L
L
A
M
D
V
P
E
E
L
G
G
A
G
L
---
D
---
Y
---
L
A
Y
A
I
A
M
E
E
I
S
R
G
C
A
S
T
G
V
I
M
S
V
N
N
S
L
Y
L
G
P
I
L
K
F
G
S
K
E
Q
K
Q
A
W
V
T
P
F
T
S
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
R
A
--
E
-
G
D
-
S
W
V
L
N
G
T
K
A
W
I
T
N
A
W
E
A
S
A
A
V
V
F
A
S
T
D
-----------------
S
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
G
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
D
S
I
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
T
A
L
D
C
A
V
N
Y
A
E
N
R
M
A
F
G
A
P
L
T
K
L
Q
V
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
N
K
K
P
F
I
K
E
A
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
H
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
G
H
L
--
30
PsiBlast_CBE
85.48
50%
-78
- C1 -
2VIG
5
ACADS_HUMAN
E:
[6-378]
----
L
P
E
T
H
Q
M
L
L
Q
T
C
R
D
F
A
E
K
E
L
F
P
I
A
A
Q
V
D
K
E
H
L
F
-
P
A
A
Q
V
K
K
M
G
G
L
G
L
L
A
M
D
V
P
E
E
L
G
G
A
G
L
---
D
---
Y
---
L
A
Y
A
I
A
M
E
E
I
S
R
G
C
A
S
T
G
V
I
M
S
V
N
N
S
L
Y
L
G
P
I
L
K
F
G
S
K
E
Q
K
Q
A
W
V
T
P
F
T
S
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
R
A
--
E
-
G
D
-
S
W
V
L
N
G
T
K
A
W
I
T
N
A
W
E
A
S
A
A
V
V
F
A
S
T
D
R
----
A
----
L
Q
---
N
K
S
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
G
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
D
S
I
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
T
A
L
D
C
A
V
N
Y
A
E
N
R
M
A
F
G
A
P
L
T
K
L
Q
V
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
N
K
K
P
F
I
K
E
A
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
H
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
G
H
L
--
27
PsiBlast_CBE
85.44
50%
-75
- C1 -
2VIG
6
ACADS_HUMAN
H:
[6-378]
----
L
P
E
T
H
Q
M
L
L
Q
T
C
R
D
F
A
E
K
E
L
F
P
I
A
A
Q
V
D
K
E
H
L
F
-
P
A
A
Q
V
K
K
M
G
G
L
G
L
L
A
M
D
V
P
E
E
L
G
G
A
G
L
---
D
---
Y
---
L
A
Y
A
I
A
M
E
E
I
S
R
G
C
A
S
T
G
V
I
M
S
V
N
N
S
L
Y
L
G
P
I
L
K
F
G
S
K
E
Q
K
Q
A
W
V
T
P
F
T
S
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
R
A
--
E
-
G
D
-
S
W
V
L
N
G
T
K
A
W
I
T
N
A
W
E
A
S
A
A
V
V
F
A
S
T
-----------------
K
S
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
G
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
D
S
I
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
T
A
L
D
C
A
V
N
Y
A
E
N
R
M
A
F
G
A
P
L
T
K
L
Q
V
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
N
K
K
P
F
I
K
E
A
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
H
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
G
H
L
--
28
PsiBlast_CBE
85.15
50%
-80
- C1 -
2VIG
7
ACADS_HUMAN
G:
[6-378]
----
L
P
E
T
H
Q
M
L
L
Q
T
C
R
D
F
A
E
K
E
L
F
P
I
A
A
Q
V
D
K
E
H
L
F
-
P
A
A
Q
V
K
K
M
G
G
L
G
L
L
A
M
D
V
P
E
E
L
G
G
A
G
L
---
D
---
Y
---
L
A
Y
A
I
A
M
E
E
I
S
R
G
C
A
S
T
G
V
I
M
S
V
N
N
S
L
Y
L
G
P
I
L
K
F
G
S
K
E
Q
K
Q
A
W
V
T
P
F
T
S
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
R
A
--
E
-
G
D
-
S
W
V
L
N
G
T
K
A
W
I
T
N
A
W
E
A
S
A
A
V
V
F
A
S
T
D
-----------
Q
---
N
K
S
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
G
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
D
S
I
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
T
A
L
D
C
A
V
N
Y
A
E
N
R
M
A
F
G
A
P
L
T
K
L
Q
V
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
N
K
K
P
F
I
K
E
A
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
H
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
G
H
L
--
33
PsiBlast_CBE
85.11
50%
-81
- C1 -
2VIG
6
ACADS_HUMAN
B:
[6-378]
----
L
P
E
T
H
Q
M
L
L
Q
T
C
R
D
F
A
E
K
E
L
F
P
I
A
A
Q
V
D
K
E
H
L
F
-
P
A
A
Q
V
K
K
M
G
G
L
G
L
L
A
M
D
V
P
E
E
L
G
G
A
G
L
---
D
---
Y
---
L
A
Y
A
I
A
M
E
E
I
S
R
G
C
A
S
T
G
V
I
M
S
V
N
N
S
L
Y
L
G
P
I
L
K
F
G
S
K
E
Q
K
Q
A
W
V
T
P
F
T
S
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
R
A
--
E
-
G
D
-
S
W
V
L
N
G
T
K
A
W
I
T
N
A
W
E
A
S
A
A
V
V
F
A
S
T
------------------
S
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
G
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
D
S
I
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
T
A
L
D
C
A
V
N
Y
A
E
N
R
M
A
F
G
A
P
L
T
K
L
Q
V
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
N
K
K
P
F
I
K
E
A
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
H
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
G
H
L
--
26
PsiBlast_CBE
85.06
53%
-66
- C1 -
3PFD
1
?
B:
[22-391]
-------
E
H
I
A
L
R
E
A
I
R
A
L
A
E
K
E
I
A
P
Y
A
A
E
V
D
E
K
A
R
F
-
P
E
E
A
L
A
A
L
N
S
S
G
F
S
A
I
H
V
P
E
E
Y
G
G
Q
G
A
---
D
---
S
---
V
A
T
C
I
V
I
E
E
V
A
R
V
D
C
S
A
S
L
-
I
P
A
V
N
K
L
G
T
M
G
L
I
L
R
G
S
E
E
L
K
K
Q
V
L
P
A
V
A
S
G
E
A
M
A
S
Y
A
L
S
E
R
E
A
G
S
D
A
A
S
M
R
T
R
A
V
A
--
D
-
G
D
-
D
W
I
L
N
G
S
K
C
W
I
T
N
G
G
K
S
T
W
Y
T
V
M
A
V
T
D
P
----
D
----
K
G
---
A
N
G
I
S
A
F
M
V
H
K
D
D
E
G
F
T
V
G
P
K
E
R
K
L
G
I
K
G
S
P
T
T
E
L
Y
F
E
N
C
R
I
P
G
D
R
I
I
G
E
P
G
T
G
F
K
T
A
L
A
T
L
D
H
T
R
P
T
I
G
A
Q
A
V
G
I
A
Q
G
A
L
D
A
A
I
A
Y
T
K
E
R
K
Q
F
G
R
P
V
S
D
N
Q
G
V
Q
F
M
L
A
D
M
A
M
K
I
E
A
A
R
L
M
V
Y
S
A
A
A
R
A
E
R
G
---
G
F
I
S
A
A
S
K
C
F
A
S
D
V
A
M
E
V
T
T
D
A
V
Q
L
F
G
G
Y
G
Y
T
Q
D
F
P
V
E
R
M
M
R
D
A
K
I
T
Q
I
Y
E
G
T
N
Q
I
Q
R
V
V
M
S
R
A
L
--
127
HHSearch
84.92
48%
-75
- C1 -
1UKW
2
?
A:
[1-378]
I
D
F
S
L
T
E
E
Q
R
Q
L
Q
A
L
A
R
R
F
A
K
E
V
I
L
P
V
A
Q
E
Y
D
E
K
E
E
V
-
P
W
P
V
I
E
K
L
H
E
V
G
L
L
N
A
I
I
P
E
E
Y
G
G
M
G
L
---
K
---
M
---
L
D
E
V
I
V
G
E
E
L
A
Y
A
C
M
G
I
Y
T
I
P
M
A
S
D
-
L
G
I
T
P
V
L
L
A
G
T
E
E
Q
K
E
R
F
L
R
P
L
T
E
K
P
A
L
A
A
F
A
L
S
E
P
G
N
G
S
D
A
A
A
L
K
T
R
A
I
R
--
Q
-
G
D
-
H
Y
V
L
N
G
T
K
M
W
I
S
N
G
G
E
A
E
W
V
V
V
F
A
T
V
N
P
----
E
----
L
R
---
H
K
G
V
V
A
L
V
V
E
R
G
T
P
G
F
K
A
I
K
I
H
G
K
M
G
Q
R
A
S
G
T
Y
E
L
V
F
E
D
V
K
V
P
V
E
N
R
L
G
E
E
G
E
G
F
K
I
A
M
Q
T
L
N
K
T
R
I
P
V
A
A
G
S
V
G
V
A
R
R
A
L
D
E
A
R
K
Y
A
K
E
R
E
A
F
G
E
P
I
A
N
F
Q
A
I
Q
F
K
L
V
D
M
L
I
G
I
E
T
A
R
M
Y
T
Y
Y
A
A
W
L
A
D
Q
G
L
P
H
A
H
A
S
A
I
A
K
A
Y
A
S
E
I
A
F
E
A
A
N
Q
A
I
Q
I
H
G
G
Y
G
Y
V
R
E
F
P
V
E
K
L
L
R
D
V
K
L
N
Q
I
Y
E
G
T
N
E
I
Q
R
L
I
I
A
R
H
I
L
A
9
PsiBlast_PDB
84.90
47%
-76
- C1 -
1UKW
2
?
A:
[1-376]
I
D
F
S
L
T
E
E
Q
R
Q
L
Q
A
L
A
R
R
F
A
K
E
V
I
L
P
V
A
Q
E
Y
D
E
K
E
E
V
-
P
W
P
V
I
E
K
L
H
E
V
G
L
L
N
A
I
I
P
E
E
Y
G
G
M
G
L
---
K
---
M
---
L
D
E
V
I
V
G
E
E
L
A
Y
A
C
M
G
I
-
Y
T
I
P
M
A
S
D
L
G
I
T
P
V
L
L
A
G
T
E
E
Q
K
E
R
F
L
R
P
L
T
E
K
P
A
L
A
A
F
A
L
S
E
P
G
N
G
S
D
A
A
A
L
K
T
R
A
I
R
--
Q
-
G
D
-
H
Y
V
L
N
G
T
K
M
W
I
S
N
G
G
E
A
E
W
V
V
V
F
A
T
V
N
P
----
E
----
L
R
---
H
K
G
V
V
A
L
V
V
E
R
G
T
P
G
F
K
A
I
K
I
H
G
K
M
G
Q
R
A
S
G
T
Y
E
L
V
F
E
D
V
K
V
P
V
E
N
R
L
G
E
E
G
E
G
F
K
I
A
M
Q
T
L
N
K
T
R
I
P
V
A
A
G
S
V
G
V
A
R
R
A
L
D
E
A
R
K
Y
A
K
E
R
E
A
F
G
E
P
I
A
N
F
Q
A
I
Q
F
K
L
V
D
M
L
I
G
I
E
T
A
R
M
Y
T
Y
Y
A
A
W
L
A
D
Q
G
L
P
H
A
H
A
S
A
I
A
K
A
Y
A
S
E
I
A
F
E
A
A
N
Q
A
I
Q
I
H
G
G
Y
G
Y
V
R
E
F
P
V
E
K
L
L
R
D
V
K
L
N
Q
I
Y
E
G
T
N
E
I
Q
R
L
I
I
A
R
H
I
--
38
PsiBlast_CBE
84.28
49%
-78
- C1 -
4M9A
1
?
C:
[10-385]
-
D
D
L
Y
T
E
D
Q
R
M
I
L
D
A
A
R
A
F
C
A
E
V
L
A
P
N
A
A
Q
W
D
R
E
S
H
L
-
P
D
E
V
V
A
Q
M
G
E
L
G
F
L
G
M
I
V
P
A
D
W
G
G
S
Y
T
---
D
---
Y
---
V
A
Y
A
L
A
L
E
E
I
A
A
G
C
A
S
C
A
T
L
V
S
V
H
N
S
V
G
C
G
P
V
L
N
Y
G
T
T
E
Q
K
E
R
W
L
R
D
L
A
S
G
K
T
V
G
A
F
S
L
T
E
P
H
A
----
H
N
L
R
T
R
A
E
L
--
R
-
D
G
-
K
W
I
L
N
G
S
K
Q
F
V
T
N
G
A
R
A
G
L
A
I
V
F
A
M
T
D
P
----
D
----
E
G
---
K
R
G
L
S
A
F
V
V
P
T
D
T
P
G
F
I
V
G
K
P
E
K
K
M
G
I
R
A
S
D
T
C
P
I
T
L
E
N
C
A
I
P
Q
E
N
L
L
G
K
R
G
E
G
L
K
I
A
L
S
N
L
E
G
G
R
I
G
I
A
A
Q
A
T
G
I
A
R
A
A
F
D
R
A
R
R
Y
A
R
E
R
V
Q
F
G
K
P
I
A
E
H
Q
A
I
A
E
K
L
A
N
M
A
T
Q
I
N
A
A
R
L
L
T
H
H
A
A
R
L
R
T
A
G
L
P
C
L
S
E
A
S
Q
A
K
L
F
A
S
E
M
A
E
A
V
C
S
D
A
I
Q
I
H
G
G
Y
G
F
L
V
D
Y
E
V
E
R
H
Y
R
D
A
R
I
T
Q
I
Y
E
G
T
S
E
V
Q
R
M
V
I
A
R
Q
L
--
4
PsiBlast_PDB
84.13
53%
-66
- C1 -
3PFD
26
?
A:
[22-391]
-------
E
H
I
A
L
R
E
A
I
R
A
L
A
E
K
E
I
A
P
Y
A
A
E
V
D
E
K
A
R
F
-
P
E
E
A
L
A
A
L
N
S
S
G
F
S
A
I
H
V
P
E
E
Y
G
G
Q
G
A
---
D
---
S
---
V
A
T
C
I
V
I
E
E
V
A
R
V
D
C
S
A
S
L
-
I
P
A
V
N
K
L
G
T
M
G
L
I
L
R
G
S
E
E
L
K
K
Q
V
L
P
A
V
A
S
G
E
A
M
A
S
Y
A
L
S
E
R
E
A
G
S
D
A
A
S
M
R
T
R
A
V
A
--
D
-
G
D
-
D
W
I
L
N
G
S
K
C
W
I
T
N
G
G
K
S
T
W
Y
T
V
M
A
V
T
D
P
----
D
----
K
G
---
A
N
G
I
S
A
F
M
V
H
K
D
D
E
G
F
T
V
G
P
K
E
R
K
L
G
I
K
G
S
P
T
T
E
L
Y
F
E
N
C
R
I
P
G
D
R
I
I
G
E
P
G
T
G
F
K
T
A
L
A
T
L
D
H
T
R
P
T
I
G
A
Q
A
V
G
I
A
Q
G
A
L
D
A
A
I
A
Y
T
K
E
R
K
Q
F
G
R
P
V
S
D
N
Q
G
V
Q
F
M
L
A
D
M
A
M
K
I
E
A
A
R
L
M
V
Y
S
A
A
A
R
A
E
R
G
---
G
F
I
S
A
A
S
K
C
F
A
S
D
V
A
M
E
V
T
T
D
A
V
Q
L
F
G
G
Y
G
Y
T
Q
D
F
P
V
E
R
M
M
R
D
A
K
I
T
Q
I
Y
E
G
T
N
Q
I
Q
R
V
V
M
S
R
A
L
--
24
PsiBlast_CBE
83.64
53%
-67
- C1 -
3PFD
8
?
D:
[22-391]
-------
E
H
I
A
L
R
E
A
I
R
A
L
A
E
K
E
I
A
P
Y
A
A
E
V
D
E
K
A
R
F
-
P
E
E
A
L
A
A
L
N
S
S
G
F
S
A
I
H
V
P
E
E
Y
G
G
Q
G
A
---
D
---
S
---
V
A
T
C
I
V
I
E
E
V
A
R
V
D
C
S
A
S
L
-
I
P
A
V
N
K
L
G
T
M
G
L
I
L
R
G
S
E
E
L
K
K
Q
V
L
P
A
V
A
S
G
E
A
M
A
S
Y
A
L
S
E
R
E
A
G
S
D
A
A
S
M
R
T
R
A
V
A
--
D
-
G
D
-
D
W
I
L
N
G
S
K
C
W
I
T
N
G
G
K
S
T
W
Y
T
V
M
A
V
T
D
P
----
D
----
K
G
---
A
N
G
I
S
A
F
M
V
H
K
D
D
E
G
F
T
V
G
P
K
E
R
K
L
G
I
K
G
S
P
T
T
E
L
Y
F
E
N
C
R
I
P
G
D
R
I
I
G
E
P
G
T
G
F
K
T
A
L
A
T
L
D
H
T
R
P
T
I
G
A
Q
A
V
G
I
A
Q
G
A
L
D
A
A
I
A
Y
T
K
E
R
K
Q
F
G
R
P
V
S
D
N
Q
G
V
Q
F
M
L
A
D
M
A
M
K
I
E
A
A
R
L
M
V
Y
S
A
A
A
R
A
E
R
G
--
L
G
F
I
S
A
A
S
K
C
F
A
S
D
V
A
M
E
V
T
T
D
A
V
Q
L
F
G
G
Y
G
Y
T
Q
D
F
P
V
E
R
M
M
R
D
A
K
I
T
Q
I
Y
E
G
T
N
Q
I
Q
R
V
V
M
S
R
A
L
--
6
PsiBlast_PDB
82.51
48%
-81
- C1 -
4N5F
10
?
A:
[9-385]
M
D
E
L
Y
T
E
D
Q
R
M
I
R
D
A
A
R
A
F
A
T
E
M
L
A
P
N
A
A
Q
W
D
H
D
A
H
L
-
P
D
A
I
V
A
Q
L
G
E
L
G
L
L
G
M
I
V
P
Q
E
L
G
G
S
Y
T
---
D
---
Y
---
V
A
Y
A
L
A
M
E
E
V
A
A
G
D
A
A
C
A
T
M
M
S
V
H
N
S
V
G
C
G
P
I
L
G
F
G
T
P
A
Q
K
D
R
W
L
A
D
M
A
A
G
R
V
I
G
A
F
C
L
T
E
P
H
A
G
S
E
A
N
N
L
R
T
R
A
E
L
--
R
-
D
G
-
Q
W
V
L
N
G
A
K
Q
F
V
T
N
G
Q
R
A
G
V
A
I
V
F
A
M
T
D
P
----
E
----
A
G
---
K
R
G
I
S
A
F
L
V
P
T
D
T
P
G
F
I
V
G
K
P
E
K
K
M
G
I
R
A
S
D
T
C
P
I
T
F
E
N
C
A
I
P
E
D
N
L
L
G
N
R
G
E
G
L
K
I
A
L
S
N
L
E
G
G
R
I
G
I
A
A
Q
A
L
G
I
A
R
A
A
F
D
K
A
R
R
Y
A
G
E
R
V
Q
F
G
K
P
I
A
E
H
Q
A
I
Q
Q
K
L
A
D
M
A
V
Q
I
N
A
A
R
L
L
V
H
H
A
A
K
L
R
T
A
G
L
P
C
L
S
E
A
S
Q
A
K
L
F
A
S
E
M
A
E
R
V
C
S
D
A
I
Q
I
H
G
G
Y
G
Y
L
V
D
Y
E
V
E
R
H
Y
R
D
A
R
I
T
Q
I
Y
E
G
T
S
E
V
Q
R
M
V
I
A
R
Q
L
--
51
PsiBlast_CBE
82.20
45%
-82
- C1 -
2DVL
2
?
B:
[3-370]
----
L
T
Q
E
Q
R
L
V
L
D
A
V
R
R
V
A
R
E
V
L
Y
P
L
A
P
E
Y
D
R
K
A
E
Y
-
P
W
P
Q
L
K
A
L
A
E
L
G
L
L
G
M
T
T
P
E
E
W
G
G
V
G
L
---
D
---
S
---
V
T
W
A
L
A
L
E
E
L
A
A
A
D
P
S
V
A
V
I
V
S
V
T
S
G
L
P
Q
Y
M
L
L
R
F
G
S
E
A
Q
K
R
R
Y
L
V
P
L
A
R
G
E
W
I
G
A
F
C
L
T
E
P
Q
A
G
S
D
A
K
S
L
R
A
E
A
R
R
--
V
-
K
G
-
G
F
V
L
N
G
V
K
S
W
I
T
S
A
G
H
A
H
L
Y
V
V
M
A
R
T
E
----------------
K
G
I
S
A
F
L
V
E
K
G
T
P
G
L
S
F
G
R
P
E
E
K
M
G
L
H
A
A
H
T
A
E
V
R
L
E
E
V
F
V
P
E
E
N
L
L
G
E
E
G
R
G
L
A
Y
A
L
A
G
L
D
S
G
R
V
G
V
A
A
Q
A
V
G
I
A
R
G
A
F
E
I
A
K
A
Y
A
E
E
R
E
Q
F
G
K
K
L
K
E
H
Q
A
I
A
F
K
I
A
D
M
H
V
K
I
A
A
A
R
A
L
V
L
E
A
A
R
K
K
D
R
G
E
R
F
T
L
E
A
S
A
A
K
L
F
A
S
A
A
A
V
E
V
T
R
E
A
V
Q
V
L
G
G
Y
G
Y
H
R
D
Y
R
V
E
R
Y
Y
R
D
A
K
V
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
R
E
L
--
13
PsiBlast_PDB
81.97
45%
-81
- C1 -
2DVL
2
?
A:
[3-370]
----
L
T
Q
E
Q
R
L
V
L
D
A
V
R
R
V
A
R
E
V
L
Y
P
L
A
P
E
Y
D
R
K
A
E
Y
-
P
W
P
Q
L
K
A
L
A
E
L
G
L
L
G
M
T
T
P
E
E
W
G
G
V
G
L
---
D
---
S
---
V
T
W
A
L
A
L
E
E
L
A
A
A
D
P
S
V
A
V
I
V
S
V
T
S
G
L
P
Q
Y
M
L
L
R
F
G
S
E
A
Q
K
R
R
Y
L
V
P
L
A
R
G
E
W
I
G
A
F
C
L
T
E
P
Q
A
G
S
D
A
K
S
L
R
A
E
A
R
R
--
V
-
K
G
-
G
F
V
L
N
G
V
K
S
W
I
T
S
A
G
H
A
H
L
Y
V
V
M
A
R
T
E
----------------
K
G
I
S
A
F
L
V
E
K
G
T
P
G
L
S
F
G
R
P
E
E
K
M
G
L
H
A
A
H
T
A
E
V
R
L
E
E
V
F
V
P
E
E
N
L
L
G
E
E
G
R
G
L
A
Y
A
L
A
G
L
D
S
G
R
V
G
V
A
A
Q
A
V
G
I
A
R
G
A
F
E
I
A
K
A
Y
A
E
E
R
E
Q
F
G
K
K
L
K
E
H
Q
A
I
A
F
K
I
A
D
M
H
V
K
I
A
A
A
R
A
L
V
L
E
A
A
R
K
K
D
R
G
E
R
F
T
L
E
A
S
A
A
K
L
F
A
S
A
A
A
V
E
V
T
R
E
A
V
Q
V
L
G
G
Y
G
Y
H
R
D
Y
R
V
E
R
Y
Y
R
D
A
K
V
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
R
E
L
--
52
PsiBlast_CBE
79.52
46%
-38
- C1 -
2D29
2
?
B:
[3-383]
L
W
F
E
E
G
A
E
E
R
Q
V
L
G
P
F
R
E
F
L
K
A
E
V
A
P
G
A
A
E
R
D
R
T
G
A
F
-
P
W
D
L
V
R
K
L
A
E
F
G
V
F
G
A
L
V
P
E
A
Y
G
G
A
G
L
---
S
---
T
---
R
L
F
A
R
M
V
E
A
I
A
Y
Y
D
G
A
L
A
L
T
V
A
S
H
N
S
L
A
T
G
H
I
L
L
A
G
S
E
A
Q
K
E
A
F
L
P
K
L
A
S
G
E
A
L
G
A
W
G
L
T
E
P
G
S
G
S
D
A
A
A
L
K
T
K
A
E
K
--
V
-
E
G
-
G
W
R
L
N
G
T
K
Q
F
I
T
Q
G
S
V
A
G
V
Y
V
V
M
A
R
T
D
P
PPSP
E
----
R
K
---
H
Q
G
I
S
A
F
A
F
F
R
P
E
R
G
L
K
V
G
R
K
E
E
K
L
G
L
T
A
S
D
T
A
Q
L
I
L
E
D
L
F
V
P
E
E
A
L
L
G
E
R
G
K
G
F
Y
D
V
L
R
V
L
D
G
G
R
I
G
I
A
A
M
A
V
G
L
G
Q
A
A
L
D
Y
A
L
A
Y
A
K
G
R
E
A
F
G
R
P
I
A
E
F
E
G
V
S
F
K
L
A
E
A
A
T
E
L
E
A
A
R
L
L
Y
L
K
A
A
E
L
K
D
A
G
R
P
F
T
L
E
A
A
Q
A
K
L
F
A
S
E
A
A
V
K
A
C
D
E
A
I
Q
I
L
G
G
Y
G
Y
V
K
D
Y
P
V
E
R
Y
W
R
D
A
R
L
T
R
I
G
E
G
T
S
E
I
L
K
L
V
I
A
R
R
L
--
126
HHSearch
79.36
47%
-35
- C1 -
2D29
2
?
A:
[4-385]
-
W
F
E
E
G
A
E
E
R
Q
V
L
G
P
F
R
E
F
L
K
A
E
V
A
P
G
A
A
E
R
D
R
T
G
A
F
-
P
W
D
L
V
R
K
L
A
E
F
G
V
F
G
A
L
V
P
E
A
Y
G
G
A
G
L
---
S
---
T
---
R
L
F
A
R
M
V
E
A
I
A
Y
Y
D
G
A
L
A
L
T
V
A
S
H
N
S
L
A
T
G
H
I
L
L
A
G
S
E
A
Q
K
E
A
F
L
P
K
L
A
S
G
E
A
L
G
A
W
G
L
T
E
P
G
S
G
S
D
A
A
A
L
K
T
K
A
E
K
--
V
-
E
G
-
G
W
R
L
N
G
T
K
Q
F
I
T
Q
G
S
V
A
G
V
Y
V
V
M
A
R
T
D
P
----
P
PSPE
R
K
---
H
Q
G
I
S
A
F
A
F
F
R
P
E
R
G
L
K
V
G
R
K
E
E
K
L
G
L
T
A
S
D
T
A
Q
L
I
L
E
D
L
F
V
P
E
E
A
L
L
G
E
R
G
K
G
F
Y
D
V
L
R
V
L
D
G
G
R
I
G
I
A
A
M
A
V
G
L
G
Q
A
A
L
D
Y
A
L
A
Y
A
K
G
R
E
A
F
G
R
P
I
A
E
F
E
G
V
S
F
K
L
A
E
A
A
T
E
L
E
A
A
R
L
L
Y
L
K
A
A
E
L
K
D
A
G
R
P
F
T
L
E
A
A
Q
A
K
L
F
A
S
E
A
A
V
K
A
C
D
E
A
I
Q
I
L
G
G
Y
G
Y
V
K
D
Y
P
V
E
R
Y
W
R
D
A
R
L
T
R
I
G
E
G
T
S
E
I
L
K
L
V
I
A
R
R
L
L
E
34
PsiBlast_CBE
79.11
48%
-88
- C1 -
4N5F
10
?
B:
[9-385]
M
D
E
L
Y
T
E
D
Q
R
M
I
R
D
A
A
R
A
F
A
T
E
M
L
A
P
N
A
A
Q
W
D
H
D
A
H
L
-
P
D
A
I
V
A
Q
L
G
E
L
G
L
L
G
M
I
V
P
Q
E
L
G
G
S
Y
T
---
D
---
Y
---
V
A
Y
A
L
A
M
E
E
V
A
A
G
D
A
A
C
A
T
M
M
S
V
H
N
S
V
G
C
G
P
I
L
G
F
G
T
P
A
Q
K
D
R
W
L
A
D
M
A
A
G
R
V
I
G
A
F
C
L
T
E
P
H
-------
L
R
T
R
A
E
L
--
R
-
D
---
W
V
L
N
G
A
K
Q
F
V
T
N
G
Q
R
A
G
V
A
I
V
F
A
M
T
D
P
----
E
----
A
G
---
K
R
G
I
S
A
F
L
V
P
T
D
T
P
G
F
I
V
G
K
P
E
K
K
M
G
I
R
A
S
D
T
C
P
I
T
F
E
N
C
A
I
P
E
D
N
L
L
G
N
R
G
E
G
L
K
I
A
L
S
N
L
E
G
G
R
I
G
I
A
A
Q
A
L
G
I
A
R
A
A
F
D
K
A
R
R
Y
A
G
E
R
V
Q
F
G
K
P
I
A
E
H
Q
A
I
Q
Q
K
L
A
D
M
A
V
Q
I
N
A
A
R
L
L
V
H
H
A
A
K
L
R
T
A
G
L
P
C
L
S
E
A
S
Q
A
K
L
F
A
S
E
M
A
E
R
V
C
S
D
A
I
Q
I
H
G
G
Y
G
Y
L
V
D
Y
E
V
E
R
H
Y
R
D
A
R
I
T
Q
I
Y
E
G
T
S
E
V
Q
R
M
V
I
A
R
Q
L
--
114
HHSearch
78.82
45%
-81
- C1 -
3NF4
1
?
A:
[15-386]
---
L
P
S
Q
E
A
A
E
L
I
E
L
T
R
E
I
A
D
K
V
L
D
P
I
V
D
R
H
E
K
D
E
T
Y
-
P
E
G
V
F
E
Q
L
G
A
A
G
L
L
S
L
P
Q
P
E
E
W
G
G
G
G
Q
---
P
---
Y
---
E
V
Y
L
Q
V
L
E
E
I
A
A
R
W
A
S
V
A
V
A
V
S
V
H
S
-
L
S
S
H
P
L
L
V
F
G
T
E
E
Q
K
K
R
W
L
P
G
M
L
S
G
E
Q
I
G
A
Y
S
L
S
E
P
Q
A
G
S
D
A
A
A
L
R
C
A
A
T
P
--
T
-
D
G
-
G
Y
V
I
N
G
S
K
S
W
I
T
H
G
G
K
A
D
F
Y
T
L
F
A
R
T
G
---------------
S
R
G
V
S
C
F
L
V
P
A
D
Q
P
G
L
S
F
G
K
P
E
E
K
M
G
L
H
A
V
P
T
T
S
A
F
Y
D
N
A
R
I
D
A
D
R
R
I
G
E
E
G
Q
G
L
Q
I
A
F
S
A
L
D
S
G
R
L
G
I
A
A
V
A
T
G
L
A
Q
A
A
L
D
E
A
V
A
Y
A
N
E
------
K
I
I
D
H
-
G
L
G
F
L
L
A
D
M
A
A
A
V
A
T
A
R
A
T
Y
L
D
A
A
R
R
R
D
Q
G
R
P
Y
S
Q
Q
A
S
I
A
K
L
T
A
T
D
A
A
M
K
V
T
T
D
A
V
Q
V
F
G
G
V
G
Y
T
R
D
Y
R
V
E
R
Y
M
R
E
A
K
I
M
Q
I
F
E
G
T
N
Q
I
Q
R
L
V
I
A
R
G
L
T
-
16
PsiBlast_PDB
78.37
46%
-34
- C1 -
2D29
2
?
A:
[3-383]
L
W
F
E
E
G
A
E
E
R
Q
V
L
G
P
F
R
E
F
L
K
A
E
V
A
P
G
A
A
E
R
D
R
T
G
A
F
-
P
W
D
L
V
R
K
L
A
E
F
G
V
F
G
A
L
V
P
E
A
Y
G
G
A
G
L
---
S
---
T
---
R
L
F
A
R
M
V
E
A
I
A
Y
Y
D
G
A
L
A
L
T
V
A
S
H
N
S
L
A
T
G
H
I
L
L
A
G
S
E
A
Q
K
E
A
F
L
P
K
L
A
S
G
E
A
L
G
A
W
G
L
T
E
P
G
S
G
S
D
A
A
A
L
K
T
K
A
E
K
--
V
-
E
G
-
G
W
R
L
N
G
T
K
Q
F
I
T
Q
G
S
V
A
G
V
Y
V
V
M
A
R
T
D
P
PPSP
E
----
R
K
---
H
Q
G
I
S
A
F
A
F
F
R
P
E
R
G
L
K
V
G
R
K
E
E
K
L
G
L
T
A
S
D
T
A
Q
L
I
L
E
D
L
F
V
P
E
E
A
L
L
G
E
R
G
K
G
F
Y
D
V
L
R
V
L
D
G
G
R
I
G
I
A
A
M
A
V
G
L
G
Q
A
A
L
D
Y
A
L
A
Y
A
K
G
R
E
A
F
G
R
P
I
A
E
F
E
G
V
S
F
K
L
A
E
A
A
T
E
L
E
A
A
R
L
L
Y
L
K
A
A
E
L
K
D
A
G
R
P
F
T
L
E
A
A
Q
A
K
L
F
A
S
E
A
A
V
K
A
C
D
E
A
I
Q
I
L
G
G
Y
G
Y
V
K
D
Y
P
V
E
R
Y
W
R
D
A
R
L
T
R
I
G
E
G
T
S
E
I
L
K
L
V
I
A
R
R
L
--
128
HHSearch
77.86
54%
-6
- C1 -
1BUC
3
ACDS_MEGEL
A:
[1-383]
M
D
F
N
L
T
D
I
Q
Q
D
F
L
K
L
A
H
D
F
G
E
K
K
L
A
P
T
V
T
E
R
D
H
K
G
I
Y
-
D
K
E
L
I
D
E
L
L
S
L
G
I
T
G
A
Y
F
E
E
K
Y
G
G
S
G
D
---
D
---
G
GD
V
L
S
Y
I
L
A
V
E
E
L
A
K
Y
D
A
G
V
A
I
T
L
S
A
T
V
S
L
C
A
N
P
I
W
Q
F
G
T
E
A
Q
K
E
K
F
L
V
P
L
V
E
G
T
K
L
G
A
F
G
L
T
E
P
N
A
G
T
D
A
S
G
Q
Q
T
I
A
T
K
--
N
D
D
G
-
T
Y
T
L
N
G
S
K
I
F
I
T
N
G
G
A
A
D
I
Y
I
V
F
A
M
T
D
K
----
S
----
K
G
---
N
H
G
I
T
A
F
I
L
E
D
G
T
P
G
F
T
Y
G
K
K
E
D
K
M
G
I
H
T
S
Q
T
M
E
L
V
F
Q
D
V
K
V
P
A
E
N
M
L
G
E
E
G
K
G
F
K
I
A
M
M
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
A
A
L
A
D
A
V
E
Y
S
K
Q
R
V
Q
F
G
K
P
L
C
K
F
Q
S
I
S
F
K
L
A
D
M
K
M
Q
I
E
A
A
R
N
L
V
Y
K
A
A
C
K
K
Q
E
G
K
P
F
T
V
D
A
A
I
A
K
R
V
A
S
D
V
A
M
R
V
T
T
E
A
V
Q
I
F
G
G
Y
G
Y
S
E
E
Y
P
V
A
R
H
M
R
D
A
K
I
T
Q
I
Y
E
G
T
N
E
V
Q
L
M
V
T
G
G
A
L
L
R
22
PsiBlast_CBE
77.10
54%
-1
- C1 -
1BUC
3
ACDS_MEGEL
B:
[1-376]
M
D
F
N
L
T
D
I
Q
Q
D
F
L
K
L
A
H
D
F
G
E
K
K
L
A
P
T
V
T
E
R
D
H
K
G
I
Y
-
D
K
E
L
I
D
E
L
L
S
L
G
I
T
G
A
Y
F
E
E
K
Y
G
G
S
G
D
---
D
GGD
V
---
L
S
Y
I
L
A
V
E
E
L
A
K
Y
D
A
G
V
A
I
T
L
S
A
T
V
S
L
C
A
N
P
I
W
Q
F
G
T
E
A
Q
K
E
K
F
L
V
P
L
V
E
G
T
K
L
G
A
F
G
L
T
E
P
N
A
G
T
D
A
S
G
Q
Q
T
I
A
T
K
--
N
-
D
D
G
T
Y
T
L
N
G
S
K
I
F
I
T
N
G
G
A
A
D
I
Y
I
V
F
A
M
T
D
K
----
S
----
K
G
---
N
H
G
I
T
A
F
I
L
E
D
G
T
P
G
F
T
Y
G
K
K
E
D
K
M
G
I
H
T
S
Q
T
M
E
L
V
F
Q
D
V
K
V
P
A
E
N
M
L
G
E
E
G
K
G
F
K
I
A
M
M
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
A
A
L
A
D
A
V
E
Y
S
K
Q
R
V
Q
F
G
K
P
L
C
K
F
Q
S
I
S
F
K
L
A
D
M
K
M
Q
I
E
A
A
R
N
L
V
Y
K
A
A
C
K
K
Q
E
G
K
P
F
T
V
D
A
A
I
A
K
R
V
A
S
D
V
A
M
R
V
T
T
E
A
V
Q
I
F
G
G
Y
G
Y
S
E
E
Y
P
V
A
R
H
M
R
D
A
K
I
T
Q
I
Y
E
G
T
N
E
V
Q
L
M
V
-------
2
PsiBlast_PDB
75.80
54%
-4
- C1 -
1BUC
3
ACDS_MEGEL
A:
[1-376]
M
D
F
N
L
T
D
I
Q
Q
D
F
L
K
L
A
H
D
F
G
E
K
K
L
A
P
T
V
T
E
R
D
H
K
G
I
Y
-
D
K
E
L
I
D
E
L
L
S
L
G
I
T
G
A
Y
F
E
E
K
Y
G
G
S
G
D
---
D
GGD
V
---
L
S
Y
I
L
A
V
E
E
L
A
K
Y
D
A
G
V
A
I
T
L
S
A
T
V
S
L
C
A
N
P
I
W
Q
F
G
T
E
A
Q
K
E
K
F
L
V
P
L
V
E
G
T
K
L
G
A
F
G
L
T
E
P
N
A
G
T
D
A
S
G
Q
Q
T
I
A
T
K
--
N
-
D
D
G
T
Y
T
L
N
G
S
K
I
F
I
T
N
G
G
A
A
D
I
Y
I
V
F
A
M
T
D
K
----
S
----
K
G
---
N
H
G
I
T
A
F
I
L
E
D
G
T
P
G
F
T
Y
G
K
K
E
D
K
M
G
I
H
T
S
Q
T
M
E
L
V
F
Q
D
V
K
V
P
A
E
N
M
L
G
E
E
G
K
G
F
K
I
A
M
M
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
A
A
L
A
D
A
V
E
Y
S
K
Q
R
V
Q
F
G
K
P
L
C
K
F
Q
S
I
S
F
K
L
A
D
M
K
M
Q
I
E
A
A
R
N
L
V
Y
K
A
A
C
K
K
Q
E
G
K
P
F
T
V
D
A
A
I
A
K
R
V
A
S
D
V
A
M
R
V
T
T
E
A
V
Q
I
F
G
G
Y
G
Y
S
E
E
Y
P
V
A
R
H
M
R
D
A
K
I
T
Q
I
Y
E
G
T
N
E
V
Q
L
M
V
-------
103
Fugue
74.59
54%
13
- C1 -
1BUC
3
ACDS_MEGEL
A:
[1-383]
M
D
F
N
L
T
D
I
Q
Q
D
F
L
K
L
A
H
D
F
G
E
K
K
L
A
P
T
V
T
E
R
D
H
K
G
I
Y
D-
K
E
L
I
D
E
L
L
S
L
G
I
T
G
A
Y
F
E
E
K
Y
G
G
S
G
D
DGG
D
---
V
---
L
S
Y
I
L
A
V
E
E
L
A
K
Y
D
A
G
V
A
I
T
L
S
A
T
V
S
L
C
A
N
P
I
W
Q
F
G
T
E
A
Q
K
E
K
F
L
V
P
L
V
E
G
T
K
L
G
A
F
G
L
T
E
P
N
A
G
T
D
A
S
G
Q
Q
T
I
A
T
K
--
N
-
D
D
G
T
Y
T
L
N
G
S
K
I
F
I
T
N
G
G
A
A
D
I
Y
I
V
F
A
M
T
D
K
----
S
----
K
G
---
N
H
G
I
T
A
F
I
L
E
D
G
T
P
G
F
T
Y
G
K
K
E
D
K
M
G
I
H
T
S
Q
T
M
E
L
V
F
Q
D
V
K
V
P
A
E
N
M
L
G
E
E
G
K
G
F
K
I
A
M
M
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
A
A
L
A
D
A
V
E
Y
S
K
Q
R
V
Q
F
G
K
P
L
C
K
F
Q
S
I
S
F
K
L
A
D
M
K
M
Q
I
E
A
A
R
N
L
V
Y
K
A
A
C
K
K
Q
E
G
K
P
F
T
V
D
A
A
I
A
K
R
V
A
S
D
V
A
M
R
V
T
T
E
A
V
Q
I
F
G
G
Y
G
Y
S
E
E
Y
P
V
A
R
H
M
R
D
A
K
I
T
Q
I
Y
E
G
T
N
E
V
Q
L
M
V
T
G
G
A
L
L
R
58
PsiBlast_CBE
74.03
43%
-24
- C1 -
3MDE
4
ACADM_PIG
B:
[2-378]
F
S
F
E
L
T
E
Q
Q
K
E
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
R
T
G
E
Y
-
P
V
P
L
L
K
R
A
W
E
L
G
L
M
N
T
H
I
P
E
S
F
G
G
L
G
L
---
G
---
I
---
I
D
S
C
L
I
T
E
E
L
A
Y
G
C
T
G
V
Q
T
A
I
E
A
N
-
T
L
G
Q
V
P
L
I
I
G
G
N
Y
Q
Q
Q
K
K
Y
L
G
R
M
T
E
E
P
L
M
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
E
K
--
K
-
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
R
S
D
P
----
D
----
P
K
APA
S
K
A
F
T
G
F
I
V
E
A
D
T
P
G
V
Q
I
G
R
K
E
I
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
R
V
P
K
E
N
V
L
T
G
E
G
A
G
F
K
I
A
M
G
T
F
D
K
T
R
P
P
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
A
E
H
Q
G
I
S
F
L
L
A
D
M
A
M
K
V
E
L
A
R
L
S
Y
Q
R
A
A
W
E
I
D
S
G
R
R
N
T
Y
Y
A
S
I
A
K
A
Y
A
A
D
I
A
N
Q
L
A
T
D
A
V
Q
V
F
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
A
Q
I
Q
R
I
I
I
A
R
----
18
PsiBlast_PDB
72.88
43%
-22
- C1 -
3MDD
2
ACADM_PIG
A:
[2-378]
F
S
F
E
L
T
E
Q
Q
K
E
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
R
T
G
E
Y
-
P
V
P
L
L
K
R
A
W
E
L
G
L
M
N
T
H
I
P
E
S
F
G
G
L
G
L
---
G
---
I
---
I
D
S
C
L
I
T
E
E
L
A
Y
G
C
T
G
V
Q
T
A
I
E
A
N
-
T
L
G
Q
V
P
L
I
I
G
G
N
Y
Q
Q
Q
K
K
Y
L
G
R
M
T
E
E
P
L
M
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
E
K
--
K
-
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
R
S
D
P
----
D
----
P
K
APA
S
K
A
F
T
G
F
I
V
E
A
D
T
P
G
V
Q
I
G
R
K
E
I
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
R
V
P
K
E
N
V
L
T
G
E
G
A
G
F
K
I
A
M
G
T
F
D
K
T
R
P
P
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
A
E
H
Q
G
I
S
F
L
L
A
D
M
A
M
K
V
E
L
A
R
L
S
Y
Q
R
A
A
W
E
I
D
S
G
R
R
N
T
Y
Y
A
S
I
A
K
A
Y
A
A
D
I
A
N
Q
L
A
T
D
A
V
Q
V
F
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
A
Q
I
Q
R
I
I
I
A
R
----
59
PsiBlast_CBE
72.59
43%
-19
- C1 -
3MDD
2
ACADM_PIG
B:
[2-378]
F
S
F
E
L
T
E
Q
Q
K
E
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
R
T
G
E
Y
-
P
V
P
L
L
K
R
A
W
E
L
G
L
M
N
T
H
I
P
E
S
F
G
G
L
G
L
---
G
---
I
---
I
D
S
C
L
I
T
E
E
L
A
Y
G
C
T
G
V
Q
T
A
I
E
A
N
-
T
L
G
Q
V
P
L
I
I
G
G
N
Y
Q
Q
Q
K
K
Y
L
G
R
M
T
E
E
P
L
M
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
E
K
--
K
-
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
R
S
D
P
----
D
----
P
K
APA
S
K
A
F
T
G
F
I
V
E
A
D
T
P
G
V
Q
I
G
R
K
E
I
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
R
V
P
K
E
N
V
L
T
G
E
G
A
G
F
K
I
A
M
G
T
F
D
K
T
R
P
P
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
A
E
H
Q
G
I
S
F
L
L
A
D
M
A
M
K
V
E
L
A
R
L
S
Y
Q
R
A
A
W
E
I
D
S
G
R
R
N
T
Y
Y
A
S
I
A
K
A
Y
A
A
D
I
A
N
Q
L
A
T
D
A
V
Q
V
F
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
A
Q
I
Q
R
I
I
I
A
R
----
19
PsiBlast_PDB
71.23
43%
-22
- C1 -
3MDE
3
ACADM_PIG
A:
[2-378]
F
S
F
E
L
T
E
Q
Q
K
E
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
R
T
G
E
Y
-
P
V
P
L
L
K
R
A
W
E
L
G
L
M
N
T
H
I
P
E
S
F
G
G
L
G
L
---
G
---
I
---
I
D
S
C
L
I
T
E
E
L
A
Y
G
C
T
G
V
Q
T
A
I
E
A
N
-
T
L
G
Q
V
P
L
I
I
G
G
N
Y
Q
Q
Q
K
K
Y
L
G
R
M
T
E
E
P
L
M
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
E
K
--
K
-
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
R
S
D
P
----
D
----
P
K
APA
S
K
A
F
T
G
F
I
V
E
A
D
T
P
G
V
Q
I
G
R
K
E
I
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
R
V
P
K
E
N
V
L
T
G
E
G
A
G
F
K
I
A
M
G
T
F
D
K
T
R
P
P
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
A
E
H
Q
G
I
S
F
L
L
A
D
M
A
M
K
V
E
L
A
R
L
S
Y
Q
R
A
A
W
E
I
D
S
G
R
R
N
T
Y
Y
A
S
I
A
K
A
Y
A
A
D
I
A
N
Q
L
A
T
D
A
V
Q
V
F
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
A
Q
I
Q
R
I
I
I
A
R
----
118
HHSearch
66.69
32%
-30
- C1 -
1SIQ
1
GCDH_HUMAN
A:
[10-383]
L
E
E
Q
L
T
T
D
E
I
L
I
R
D
T
F
R
T
Y
C
Q
E
R
L
M
P
R
I
L
L
A
N
R
N
E
V
F
-
H
R
E
I
I
S
E
M
G
E
L
G
V
L
G
P
T
I
K
-
G
Y
G
C
A
G
V
---
S
---
S
---
V
A
Y
G
L
L
A
R
E
L
E
R
V
D
S
G
Y
R
S
A
M
S
V
Q
S
S
L
V
M
H
P
I
Y
A
Y
G
S
E
E
Q
R
Q
K
Y
L
P
Q
L
A
K
G
E
L
L
G
C
F
G
L
T
E
P
N
S
G
S
D
P
S
S
M
E
T
R
A
H
Y
NS
S
-
N
K
-
S
Y
T
L
N
G
T
K
T
W
I
T
N
S
P
M
A
D
L
F
V
V
W
A
R
C
E
D
---------------
G
C
I
R
G
F
L
L
E
K
G
M
R
G
L
S
A
P
R
I
Q
G
K
F
S
L
R
A
S
A
T
G
M
I
I
M
D
G
V
E
V
P
E
E
N
V
L
P
G
A
S
-
S
L
G
G
P
F
G
C
L
N
N
A
R
Y
G
I
A
W
G
V
L
G
A
S
E
F
C
L
H
T
A
R
Q
Y
A
L
D
R
M
Q
F
G
V
P
L
A
R
N
Q
L
I
Q
K
K
L
A
D
M
L
T
E
I
T
L
G
L
H
A
C
L
Q
L
G
R
L
K
D
Q
D
K
A
A
P
E
M
V
S
L
L
K
R
N
N
C
G
K
A
L
D
I
A
R
Q
A
R
D
M
L
G
G
N
G
I
S
D
E
Y
H
V
I
R
H
A
M
N
L
E
A
V
N
T
Y
E
G
T
H
D
I
H
A
L
I
L
G
R
A
I
T
-