@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu38360: (2016-08-03 )
MKLLTLKKAHAAKIKKGYPLIEKEALAGSAGHMKEGDLVDIVSESGGEFLARGYYGLQNKGVGWTLTRNKHEQIDQAFFLSKLTKAAQARAKLFEAQDTTAFRLFNGEGDGVGGVTIDYYDGYLLIQWYSKGIYTFKDMLISALDEMDLDYKAIYEKKRFDTAGQYVEDDDFVKGRRGEFPIIIQENGIQYAVDLNEGAMTGIFLDQRHVRKAIRDRYAKGKTVLNTFSYTGAFSVAAALGGAEKTTSVDVANRSLAKTIEQFSVNKLDYEAHDIKVMDVFNYFSYAAKKDLRFDLIILDPPSFARTKKRTFSAAKDYKNLLKETIAITADKGVIVASTNSSAFGMKKFKGFIDAAFKETNERYTIIEEFTLPEDFKTISAFPEGNYLKVVLLQKK
Atome Classification :
(20 SA)
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10..-......20........30...---.....40........50........60........70........80........90........100.......110.......120.......130.....-----...140.......-150......--.160--.-.--.--.-...170.....-...180--........190.......200.......210.......-220.......230.......240.......250.......260.......270.....-..280.........290.--......300.......310.......320.......330.......340.......350.......360.......370........380.......390....-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MK
L
L
T
L
K
K
A
H
A
A
K
-IKKGYPL
I
E
K
E
ALAGSAGHMK---EG
D
L
V
D
I
V
S
ESGG
E
F
L
A
R
G
YYGLQNKGV
G
W
T
LTR
N
K
H
E
Q
I
D
Q
A
F
F
L
S
K
L
T
K
A
A
Q
A
R
A
K
L
FEAQD
T
T
A
F
R
L
FNGEGDGV
G
G
V
T
I
D
YYD
G
Y
L
L
I
Q
WYS-K
G
I
Y
T
F
-----
K
D
M
L
I
S
A
L
D
EMD
L
-
D
Y
K
A
I
Y
E
K
K--RFDT--A-G--Q--Y-VEDDD-FVKGR-RGEF
P
---
I
I
I
QEN
G
I
Q
Y
A
V
DLNEGAM
T
G
I
FL
D
Q
R
H
V
R
K
A
I
R
D
R
YA-KG
K
T
V
L
N
T
FSYT
G
A
F
S
V
A
A
A
LGGAEKT
T
S
V
D
V
A
N
R
S
L
A
K
T
I
E
Q
FSVNKLDYEAH
D
I
K
V
-
M
D
V
--
F
N
Y
F
S
Y
A
AKKD
L
R
--
F
D
L
I
I
LDPPS
F
A
R
T
K
K
R
T
F
S
A
A
K
D
Y
K
N
L
L
K
E
T
I
A
ITADK
G
V
I
V
ASTNSSAF
G
M
K
K
F
K
G
F
I
D
A
A
F
K
ETNE
R
Y
T
I
I
E
EF-TLP
E
D
F
K
T
I
SAFPEG
N
Y
L
K
V
V
L
L
QKK-
20
Fugue
97.29
48%
-93
- C1 -
3VSE
1
?
A:
[1-390]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
I
A
T
L
N
K
G
K
E
T
K
-
Y
F
N
G
Y
P
L
I
E
E
E
D
I
Y
-
S
Q
D
H
L
K
---
E
G
D
I
F
Q
I
V
T
D
K
S
-
Q
Y
V
A
T
A
Y
V
G
R
Q
H
K
G
L
G
W
V
L
T
Y
D
K
A
Q
E
I
N
T
A
F
F
V
K
L
F
N
T
A
L
A
E
R
D
Y
Y
F
N
I
D
G
T
N
A
F
R
L
F
N
A
E
G
D
G
V
G
G
L
T
I
D
N
Y
D
G
H
L
L
I
Q
W
Y
S
-
K
G
I
Y
K
F
-----
K
Y
A
I
L
E
A
V
R
K
V
-
F
-
D
Y
K
S
I
Y
E
K
V
--
R
F
K
D
--
S
-
E
--------
Y
S
G
G
-
F
V
E
G
D
-
A
P
E
F
P
---
I
V
I
E
E
N
F
T
F
Y
N
V
D
L
E
D
G
L
M
T
G
I
F
L
D
Q
K
E
V
R
K
K
L
R
G
Q
Y
A
-
K
E
R
H
V
L
N
L
F
S
Y
T
G
A
F
S
V
I
A
A
-
S
E
A
S
S
T
T
S
V
D
L
A
N
R
S
R
S
L
T
E
E
N
F
G
L
N
A
I
D
P
K
S
Q
Y
I
Y
V
-
M
D
T
--
F
D
F
Y
K
Y
A
A
R
H
G
H
S
--
Y
D
T
I
V
I
D
P
P
S
F
A
R
N
K
K
R
T
F
S
V
Q
K
D
Y
D
K
L
I
N
G
A
L
N
I
L
S
S
E
G
T
L
L
L
C
T
N
A
S
V
Y
P
L
K
Q
F
K
N
T
I
K
K
T
L
E
E
S
G
V
D
Y
E
L
T
E
V
M
-
G
L
P
K
D
F
K
T
H
P
H
Y
K
P
S
K
Y
L
K
A
V
F
V
N
I
R
H
1
PsiBlast_PDB
97.26
48%
-95
- C1 -
3VSE
1
?
A:
[1-387]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
I
A
T
L
N
K
G
K
E
T
K
-
Y
F
N
G
Y
P
L
I
E
E
E
D
I
Y
-
S
Q
D
H
L
K
---
E
G
D
I
F
Q
I
V
T
D
K
S
-
Q
Y
V
A
T
A
Y
V
G
R
Q
H
K
G
L
G
W
V
L
T
Y
D
K
A
Q
E
I
N
T
A
F
F
V
K
L
F
N
T
A
L
A
E
R
D
Y
Y
F
N
I
D
G
T
N
A
F
R
L
F
N
A
E
G
D
G
V
G
G
L
T
I
D
N
Y
D
G
H
L
L
I
Q
W
Y
S
-
K
G
I
Y
K
F
-----
K
Y
A
I
L
E
A
V
R
K
V
-
F
-
D
Y
K
S
I
Y
E
K
V
--
R
F
K
D
--
S
----
E
--
Y
---
S
G
G
-
F
V
E
G
D
-
A
P
E
F
P
---
I
V
I
E
E
N
F
T
F
Y
N
V
D
L
E
D
G
L
M
T
G
I
F
L
D
Q
K
E
V
R
K
K
L
R
G
Q
Y
A
-
K
E
R
H
V
L
N
L
F
S
Y
T
G
A
F
S
V
I
A
A
-
S
E
A
S
S
T
T
S
V
D
L
A
N
R
S
R
S
L
T
E
E
N
F
G
L
N
A
I
D
P
K
S
Q
Y
I
Y
V
-
M
D
T
--
F
D
F
Y
K
Y
A
A
R
H
G
H
S
--
Y
D
T
I
V
I
D
P
P
S
F
A
R
N
K
K
R
T
F
S
V
Q
K
D
Y
D
K
L
I
N
G
A
L
N
I
L
S
S
E
G
T
L
L
L
C
T
N
A
S
V
Y
P
L
K
Q
F
K
N
T
I
K
K
T
L
E
E
S
G
V
D
Y
E
L
T
E
V
M
-
G
L
P
K
D
F
K
T
H
P
H
Y
K
P
S
K
Y
L
K
A
V
F
V
N
---
18
PsiBlast_CBE
95.85
48%
-92
- C1 -
3VSE
1
?
C:
[2-387]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
A
T
L
N
K
G
K
E
T
K
-
Y
F
N
G
Y
P
L
I
E
E
E
D
I
Y
-
S
Q
D
H
L
K
---
E
G
D
I
F
Q
I
V
T
D
K
S
-
Q
Y
V
A
T
A
Y
V
G
R
Q
H
K
G
L
G
W
V
L
T
Y
D
K
A
Q
E
I
N
T
A
F
F
V
K
L
F
N
T
A
L
A
E
R
D
Y
Y
F
N
I
D
G
T
N
A
F
R
L
F
N
A
E
G
D
G
V
G
G
L
T
I
D
N
Y
D
G
H
L
L
I
Q
W
Y
S
-
K
G
I
Y
K
F
-----
K
Y
A
I
L
E
A
V
R
K
V
-
F
-
D
Y
K
S
I
Y
E
K
V
--
R
F
----------------
S
G
G
-
F
V
E
G
D
-
A
P
E
F
P
---
I
V
I
E
E
N
F
T
F
Y
N
V
D
L
E
D
G
L
M
T
G
I
F
L
D
Q
K
E
V
R
K
K
L
R
G
Q
Y
A
-
K
E
R
H
V
L
N
L
F
S
Y
T
G
A
F
S
V
I
A
A
-
S
E
A
S
S
T
T
S
V
D
L
A
N
R
S
R
S
L
T
E
E
N
F
G
L
N
A
I
D
P
K
S
Q
Y
I
Y
V
-
M
D
T
--
F
D
F
Y
K
Y
A
A
R
H
G
H
S
--
Y
D
T
I
V
I
D
P
P
S
F
A
R
N
K
K
R
T
F
S
V
Q
K
D
Y
D
K
L
I
N
G
A
L
N
I
L
S
S
E
G
T
L
L
L
C
T
N
A
S
V
Y
P
L
K
Q
F
K
N
T
I
K
K
T
L
E
E
S
G
V
D
Y
E
L
T
E
V
M
-
G
L
P
K
D
F
K
T
H
P
H
Y
K
P
S
K
Y
L
K
A
V
F
V
N
---
17
PsiBlast_CBE
95.75
48%
-91
- C1 -
3VSE
1
?
D:
[2-387]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
A
T
L
N
K
G
K
E
T
K
-
Y
F
N
G
Y
P
L
I
E
E
E
D
I
---
Q
D
H
L
K
---
E
G
D
I
F
Q
I
V
T
D
K
S
-
Q
Y
V
A
T
A
Y
V
G
R
Q
H
K
G
L
G
W
V
L
T
Y
D
K
A
Q
E
I
N
T
A
F
F
V
K
L
F
N
T
A
L
A
E
R
D
Y
Y
F
N
I
D
G
T
N
A
F
R
L
F
N
A
E
G
D
G
V
G
G
L
T
I
D
N
Y
D
G
H
L
L
I
Q
W
Y
S
-
K
G
I
Y
K
F
-----
K
Y
A
I
L
E
A
V
R
K
V
-
F
-
D
Y
K
S
I
Y
E
K
V
--
R
F
----------------
S
G
G
-
F
V
E
G
D
-
A
P
E
F
P
---
I
V
I
E
E
N
F
T
F
Y
N
V
D
L
E
D
G
L
M
T
G
I
F
L
D
Q
K
E
V
R
K
K
L
R
G
Q
Y
A
-
K
E
R
H
V
L
N
L
F
S
Y
T
G
A
F
S
V
I
A
A
-
S
E
A
S
S
T
T
S
V
D
L
A
N
R
S
R
S
L
T
E
E
N
F
G
L
N
A
I
D
P
K
S
Q
Y
I
Y
V
-
M
D
T
--
F
D
F
Y
K
Y
A
A
R
H
G
H
S
--
Y
D
T
I
V
I
D
P
P
S
F
A
R
N
K
K
R
T
F
S
V
Q
K
D
Y
D
K
L
I
N
G
A
L
N
I
L
S
S
E
G
T
L
L
L
C
T
N
A
S
V
Y
P
L
K
Q
F
K
N
T
I
K
K
T
L
E
E
S
G
V
D
Y
E
L
T
E
V
M
-
G
L
P
K
D
F
K
T
H
P
H
Y
K
P
S
K
Y
L
K
A
V
F
V
N
---
32
HHSearch
95.54
48%
-94
* C1 *
3VSE
1
?
A:
[1-388]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
I
A
T
L
N
K
G
K
E
T
K
-
Y
F
N
G
Y
P
L
I
E
E
E
D
I
Y
S
Q
D
-
H
L
K
---
E
G
D
I
F
Q
I
V
T
-
D
K
S
Q
Y
V
A
T
A
Y
V
G
R
Q
H
K
G
L
G
W
V
L
T
Y
D
K
A
Q
E
I
N
T
A
F
F
V
K
L
F
N
T
A
L
A
E
R
D
Y
Y
F
N
I
D
G
T
N
A
F
R
L
F
N
A
E
G
D
G
V
G
G
L
T
I
D
N
Y
D
G
H
L
L
I
Q
W
Y
S
-
K
G
I
Y
K
F
-----
K
Y
A
I
L
E
A
V
R
K
V
F
D
--
Y
K
S
I
Y
E
K
V
--
R
F
K
D
-------
S
--
E
-
Y
-
S
G
G
-
F
V
E
G
D
-
A
P
E
F
P
---
I
V
I
E
E
N
F
T
F
Y
N
V
D
L
E
D
G
L
M
T
G
I
F
L
D
Q
K
E
V
R
K
K
L
R
G
Q
Y
A
-
K
E
R
H
V
L
N
L
F
S
Y
T
G
A
F
S
V
I
A
A
S
E
-
A
S
S
T
T
S
V
D
L
A
N
R
S
R
S
L
T
E
E
N
F
G
L
N
A
I
D
P
K
S
Q
Y
I
Y
V
-
M
D
T
--
F
D
F
Y
K
Y
A
A
R
H
G
H
S
--
Y
D
T
I
V
I
D
P
P
S
F
A
R
N
K
K
R
T
F
S
V
Q
K
D
Y
D
K
L
I
N
G
A
L
N
I
L
S
S
E
G
T
L
L
L
C
T
N
A
S
V
Y
P
L
K
Q
F
K
N
T
I
K
K
T
L
E
E
S
G
V
D
Y
E
L
T
E
V
M
-
G
L
P
K
D
F
K
T
H
P
H
Y
K
P
S
K
Y
L
K
A
V
F
V
N
I
--
19
PsiBlast_CBE
94.82
48%
-92
- C1 -
3VSE
1
?
B:
[1-387]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
I
A
T
L
N
K
G
K
E
T
K
-
Y
F
N
G
Y
P
L
I
E
E
E
D
I
Y
-
S
Q
D
H
L
K
---
E
G
D
I
F
Q
I
V
T
D
K
S
-
Q
Y
V
A
T
A
Y
V
G
R
Q
H
K
G
L
G
W
V
L
T
Y
D
K
A
Q
E
I
N
T
A
F
F
V
K
L
F
N
T
A
L
A
E
R
D
Y
Y
F
N
I
D
G
T
N
A
F
R
L
F
N
A
E
G
D
G
V
G
G
L
T
I
D
N
Y
D
G
H
L
L
I
Q
W
Y
S
-
K
G
I
Y
K
F
-----
K
Y
A
I
L
E
A
V
R
K
V
-
F
-
D
Y
K
S
I
Y
E
K
V
--
R
F
----------------
S
G
G
-
F
V
E
G
D
-
A
P
E
F
P
---
I
V
I
E
E
N
F
T
F
Y
N
V
D
L
E
D
G
L
M
T
G
I
F
L
D
Q
K
E
V
R
K
K
L
R
G
Q
Y
A
-
K
E
R
H
V
L
N
L
F
S
Y
T
G
A
F
S
V
I
A
A
-
S
E
A
S
S
T
T
S
V
D
L
A
N
R
S
R
S
L
T
E
E
N
F
G
L
N
A
I
D
P
K
S
Q
Y
I
Y
V
-
M
D
T
--
F
D
F
Y
K
Y
A
A
R
H
G
H
S
--
Y
D
T
I
V
I
D
P
P
S
F
A
R
N
K
K
R
T
F
S
V
Q
K
D
Y
D
K
L
I
N
G
A
L
N
I
L
S
S
E
G
T
L
L
L
C
T
N
A
S
V
Y
P
L
K
Q
F
K
N
T
I
K
K
T
L
E
E
S
G
V
D
Y
E
L
T
E
V
M
-
G
L
P
K
D
F
K
T
H
P
H
Y
K
P
S
K
Y
L
K
A
V
F
V
N
---
21
Fugue
90.57
40%
-89
- C1 -
3LDF
1
?
A:
[1-385]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
K
L
M
V
G
S
F
A
E
K
K
-
L
K
R
G
V
Q
L
L
S
S
R
D
Y
P
N
L
N
L
------
D
N
Q
V
V
Q
L
Y
S
D
A
D
-
I
F
L
G
T
A
Y
L
S
K
Q
N
K
G
V
G
W
L
I
S
-
P
K
K
V
S
L
N
V
T
Y
F
I
K
L
F
Q
W
S
K
D
K
R
K
N
F
A
H
S
K
L
T
T
A
Y
R
L
F
N
Q
D
G
D
S
F
G
G
V
T
I
D
C
Y
G
D
F
V
L
F
S
W
Y
N
-
S
F
V
Y
Q
I
-----
R
D
E
I
V
A
A
F
R
Q
V
Y
P
-
N
F
L
G
A
Y
E
K
I
--
R
F
N
V
---------------
S
A
-
H
L
Y
G
Q
-
E
A
P
E
Q
---
F
L
I
L
E
N
G
I
S
Y
N
V
F
L
N
D
G
L
M
T
G
I
F
L
D
Q
R
Q
V
R
N
E
L
I
N
G
S
A
-
A
G
K
T
V
L
N
L
F
S
Y
T
A
A
F
S
V
A
A
A
M
G
G
A
M
A
T
T
S
V
D
L
A
K
R
S
R
A
L
S
L
A
H
F
E
A
N
H
L
D
M
A
N
H
Q
L
V
V
-
M
D
V
--
F
D
Y
F
K
Y
A
R
R
H
H
L
T
--
Y
D
I
I
I
I
D
P
P
S
F
A
R
-
N
K
E
V
F
S
V
S
K
D
Y
H
K
L
I
R
Q
G
L
E
I
L
S
E
N
G
L
I
I
A
S
T
N
A
A
N
M
T
V
S
Q
F
K
K
Q
I
E
K
G
F
G
K
Q
K
H
T
Y
L
D
L
Q
---
Q
L
P
S
D
F
A
V
N
V
Q
D
E
S
S
N
Y
L
K
V
F
T
I
K
V
--
23
Fugue
89.75
39%
-88
- C1 -
2B78
-
?
A:
[1-385]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
K
L
M
V
G
S
F
A
E
K
K
-
L
K
R
G
V
Q
L
L
S
S
R
D
Y
P
N
L
N
---
L
---
D
N
Q
V
V
Q
L
Y
S
-
D
A
D
I
F
L
G
T
A
Y
L
S
K
Q
N
K
G
V
G
W
L
I
S
P
K
K
-
V
S
L
N
V
T
Y
F
I
K
L
F
Q
W
S
K
D
K
R
K
N
F
A
H
S
K
L
T
T
A
Y
R
L
F
N
Q
D
G
D
S
F
G
G
V
T
I
D
C
Y
G
D
F
V
L
F
S
W
Y
N
-
S
F
V
Y
Q
I
-----
R
D
E
I
V
A
A
F
R
Q
V
Y
P
-
N
F
L
G
A
Y
E
K
I
--
R
F
N
V
--
S
-
A
--
H
--
L
-
Y
--------
G
Q
-
E
A
P
E
Q
---
F
L
I
L
E
N
G
I
S
Y
N
V
F
L
N
D
G
L
M
T
G
I
F
L
D
Q
R
Q
V
R
N
E
L
I
N
G
S
A
-
A
G
K
T
V
L
N
L
F
S
Y
T
A
A
F
S
V
A
A
A
M
G
G
A
M
A
T
T
S
V
D
L
A
K
R
S
R
A
L
S
L
A
H
F
E
A
N
H
L
D
M
A
N
H
Q
L
V
V
-
M
D
V
--
F
D
Y
F
K
Y
A
R
R
H
H
L
T
--
Y
D
I
I
I
I
D
P
P
S
F
E
V
F
-----
S
V
S
K
D
Y
H
K
L
I
R
Q
G
L
E
I
L
S
E
N
G
L
I
I
A
S
T
N
A
A
N
M
T
V
S
Q
F
K
K
Q
I
E
K
G
F
G
K
Q
K
--
H
T
Y
L
D
L
Q
-
Q
L
P
S
D
F
A
V
N
V
Q
D
E
S
S
N
Y
L
K
V
F
T
I
K
V
--
33
HHSearch
75.80
31%
-30
- C1 -
3C0K
-
RLMI_ECOLI
A:
[2-396]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
R
L
V
L
A
K
G
R
E
K
S
-
L
L
R
R
H
P
W
V
F
S
G
A
V
A
R
M
E
G
K
A
S
---
L
G
E
T
I
D
I
V
D
-
H
Q
G
K
W
L
A
R
G
A
Y
S
P
A
S
Q
I
R
A
R
V
W
T
F
D
P
S
E
S
I
D
I
A
F
F
S
R
R
L
Q
Q
A
Q
K
W
R
D
W
L
A
Q
K
D
G
L
D
S
Y
R
L
I
A
G
E
S
D
G
L
P
G
I
T
I
D
R
F
G
N
F
L
V
L
Q
L
L
S
-
A
G
A
E
Y
Q
-----
R
A
A
L
I
S
A
L
Q
T
L
Y
P
--
E
C
S
I
Y
D
R
S
--
D
V
A
V
R
K
K
-
E
--
G
--
M
-
E
L
T
Q
G
-
P
V
T
G
E
-
L
P
P
A
L
---
L
P
I
E
E
H
G
M
K
L
L
V
D
I
Q
H
G
H
K
T
G
Y
Y
L
D
Q
R
D
S
R
L
A
T
R
R
-
Y
V
-
E
N
K
R
V
L
N
C
F
S
Y
T
G
G
F
A
V
S
A
L
M
G
G
C
S
Q
V
V
S
V
D
T
S
Q
E
A
L
D
I
A
R
Q
N
V
E
L
N
K
L
D
L
S
K
A
E
F
V
R
-
D
D
V
--
F
K
L
L
R
T
Y
R
D
R
G
E
K
--
F
D
V
I
V
M
D
P
P
K
F
V
E
N
K
S
Q
L
M
G
A
C
R
G
Y
K
D
I
N
M
L
A
I
Q
L
L
N
E
G
G
I
L
L
T
F
S
C
S
G
L
M
T
S
D
L
F
Q
K
I
I
A
D
A
A
I
D
A
G
R
D
V
Q
F
I
E
Q
F
-
R
Q
A
A
D
H
P
V
I
A
T
Y
P
E
G
L
Y
L
K
G
F
A
C
R
V
M
-
2
PsiBlast_PDB
73.43
32%
-12
- C1 -
3C0K
-
RLMI_ECOLI
A:
[5-389]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
L
A
K
G
R
E
K
S
-
L
L
R
R
H
P
W
V
F
S
G
A
V
A
R
M
E
G
K
A
S
---
L
G
E
T
I
D
I
V
D
H
Q
G
-
K
W
L
A
R
G
A
Y
S
P
A
S
Q
I
R
A
R
V
W
T
F
D
P
S
E
S
I
D
I
A
F
F
S
R
R
L
Q
Q
A
Q
K
W
R
D
W
L
A
Q
K
D
G
L
D
S
Y
R
L
I
A
G
E
S
D
G
L
P
G
I
T
I
D
R
F
G
N
F
L
V
L
Q
L
L
S
-
A
G
A
E
Y
Q
-----
R
A
A
L
I
S
A
L
Q
T
L
----
Y
P
E
C
S
I
Y
D
--
R
S
D
V
--
A
-
V
--
R
--
K
-
K
E
G
M
E
-
L
T
Q
G
P
V
T
G
E
L
P
PA
L
L
P
I
E
E
H
G
M
K
L
L
V
D
I
Q
H
G
H
K
T
G
Y
Y
L
D
Q
R
D
S
R
L
A
T
R
-
R
Y
V
-
E
N
K
R
V
L
N
C
F
S
Y
T
G
G
F
A
V
S
A
L
M
G
G
C
S
Q
V
V
S
V
D
T
S
Q
E
A
L
D
I
A
R
Q
N
V
E
L
N
K
L
D
L
S
K
A
E
F
V
R
-
D
D
V
--
F
K
L
L
R
T
Y
R
D
R
G
E
K
--
F
D
V
I
V
M
D
P
P
K
F
V
E
N
K
S
Q
L
M
G
A
C
R
G
Y
K
D
I
N
M
L
A
I
Q
L
L
N
E
G
G
I
L
L
T
F
S
C
S
G
L
M
T
S
D
L
F
Q
K
I
I
A
D
A
A
I
D
A
G
R
D
V
Q
F
I
E
Q
F
-
R
Q
A
A
D
H
P
V
I
A
T
Y
P
E
G
L
Y
L
K
--------
7
PsiBlast_PDB
70.71
25%
-20
- C1 -
4DMG
1
?
A:
[8-381]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
V
K
A
G
K
E
R
K
-
L
R
N
F
Y
P
N
L
Y
R
D
E
I
A
A
P
P
-------
E
G
V
G
V
A
E
A
V
D
A
E
G
H
F
L
A
V
G
Y
Y
D
P
R
S
R
-
V
P
F
R
A
F
R
F
D
P
G
P
L
N
R
A
F
F
Q
G
R
F
A
R
A
L
R
R
R
Q
G
L
G
E
S
H
-----
R
L
V
H
G
E
A
D
G
L
P
G
L
V
V
D
R
F
G
E
V
L
V
L
Q
V
R
S
-
R
G
M
E
A
L
-----
R
E
V
W
L
P
A
L
L
E
V
-
V
-
A
P
K
G
V
Y
E
R
S
--
D
V
E
A
--
R
-
R
--
Q
E
G
L
-
P
E
R
V
G
-
V
V
Y
G
E
-
V
P
E
V
----
L
E
V
E
E
D
G
L
R
F
P
I
P
L
A
L
A
Q
K
T
G
Y
Y
L
D
Q
R
E
N
R
R
L
F
E
A
M
V
R
-
P
G
E
R
V
L
D
V
Y
S
Y
V
G
G
F
A
L
R
A
A
R
K
G
A
-
Y
A
L
A
V
D
-------
K
D
L
E
A
L
G
V
--
L
D
Q
A
A
L
R
L
G
L
R
V
D
I
--
R
H
G
E
A
L
P
T
L
R
G
L
E
G
P
F
H
H
V
L
L
D
P
P
T
L
V
K
R
P
E
E
L
P
A
M
K
R
H
L
V
D
L
V
R
E
A
L
R
L
L
A
E
E
G
F
L
W
L
S
S
C
S
Y
H
L
R
L
E
D
L
L
E
V
A
R
R
A
A
A
D
L
G
R
R
L
R
V
H
R
V
T
-
Y
Q
P
E
D
H
P
W
S
L
H
I
P
E
S
L
Y
L
K
T
L
V
L
Q
---
34
HHSearch
70.51
24%
-36
- C1 -
1WXX
6
?
A:
[2-382]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
Q
V
N
A
K
G
A
A
R
-
L
L
S
R
H
L
W
V
F
R
R
D
V
V
S
G
P
E
--
T
---
P
G
-
L
Y
P
V
Y
--
W
G
R
R
F
L
A
L
A
L
Y
N
P
H
T
D
L
A
V
R
A
Y
R
F
A
P
A
E
D
P
-
V
A
A
L
L
E
N
L
A
Q
A
L
A
R
R
E
A
V
L
R
Q
D
P
E
G
G
Y
R
L
V
H
A
E
G
D
L
L
P
G
L
V
V
D
Y
Y
A
G
H
A
V
V
Q
A
T
A
-
H
A
W
E
G
L
-----
L
P
Q
V
A
E
A
L
R
P
H
----
V
Q
S
V
L
A
K
N
--
D
A
R
T
--
R
-
E
L
E
G
--
L
-
P
L
Y
V
R
-
P
L
L
G
E
-
V
-
P
E
R
---
V
Q
V
Q
E
G
R
V
R
Y
L
V
D
L
R
A
G
Q
K
T
G
A
Y
L
D
Q
R
E
N
R
L
Y
M
E
R
--
F
-
R
G
E
R
A
L
D
V
F
S
Y
A
G
G
F
A
L
H
L
A
L
G
-
F
R
E
V
V
A
V
D
S
S
A
E
A
L
R
R
A
E
E
N
A
R
L
N
G
L
G
--
N
V
R
V
L
E
-
A
N
A
--
F
D
L
L
R
R
L
E
K
E
G
E
R
--
F
D
L
V
V
L
D
P
P
A
F
A
K
G
K
K
D
V
E
R
A
Y
R
A
Y
K
E
V
N
L
R
A
I
K
L
L
K
E
G
G
I
L
A
T
A
S
C
S
H
H
M
T
E
P
L
F
Y
A
M
V
A
E
A
A
Q
D
A
H
R
L
L
R
V
V
E
K
R
-
G
Q
P
F
D
H
P
V
L
L
N
H
P
E
T
H
Y
L
K
F
A
V
F
Q
V
L
-
22
Fugue
68.38
23%
-46
- C1 -
2CWW
3
?
A:
[1-382]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
R
-
I
Q
V
N
A
K
G
A
A
R
-
L
L
S
R
H
L
W
V
F
R
R
D
V
V
S
G
---
P
E
---
T
P
G
L
Y
P
V
Y
W
--
G
R
R
F
L
A
L
A
L
Y
N
P
H
T
D
L
A
V
R
A
Y
R
F
A
P
-
A
E
D
P
V
A
A
L
L
E
N
L
A
Q
A
L
A
R
R
E
A
V
L
R
Q
D
P
E
G
G
Y
R
L
V
H
A
E
G
D
L
L
P
G
L
V
V
D
Y
Y
A
G
H
A
V
V
Q
A
T
A
-
H
A
W
E
G
L
-----
L
P
Q
V
A
E
A
L
R
P
H
----
V
Q
S
V
L
A
K
N
--
D
A
R
T
--
R
-
E
--
L
--
E
G
L
P
L
Y
V
-
R
P
L
L
G
-
E
V
P
E
R
---
V
Q
V
Q
E
G
R
V
R
Y
L
V
D
L
------
G
A
Y
L
D
Q
R
E
N
R
L
Y
M
E
R
F
---
R
G
E
R
A
L
D
V
F
S
Y
A
G
G
F
A
L
H
L
A
-
L
G
F
R
E
V
V
A
V
D
S
S
A
E
A
L
R
R
A
E
E
N
A
R
L
N
G
L
G
--
N
V
R
V
L
E
-
A
N
A
--
F
D
L
L
R
R
L
E
K
E
G
E
R
--
F
D
L
V
V
L
D
P
P
A
F
A
K
G
K
K
D
V
E
R
A
Y
R
A
Y
K
E
V
N
L
R
A
I
K
L
L
K
E
G
G
I
L
A
T
A
S
C
S
H
H
M
T
E
P
L
F
Y
A
M
V
A
E
A
A
Q
D
A
H
R
L
L
R
V
V
E
K
R
-
G
Q
P
F
D
H
P
V
L
L
N
H
P
E
T
H
Y
L
K
F
A
V
F
Q
V
L
-
35
HHSearch
68.20
24%
-24
- C1 -
4DMG
1
?
A:
[6-382]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
L
V
V
K
A
G
K
E
R
K
-
L
R
N
F
Y
P
N
L
Y
R
D
E
I
A
A
P
P
---
E
---
G
V
G
V
A
E
A
V
D
-
A
E
G
H
F
L
A
V
G
Y
Y
D
P
R
S
R
V
P
F
R
A
F
R
F
D
P
-
G
P
L
N
R
A
F
F
Q
G
R
F
A
R
A
L
R
R
R
Q
G
L
-----
G
E
S
H
R
L
V
H
G
E
A
D
G
L
P
G
L
V
V
D
R
F
G
E
V
L
V
L
Q
V
R
S
-
R
G
M
E
A
L
-----
R
E
V
W
L
P
A
L
L
E
V
V
A
--
P
K
G
V
Y
E
R
S
--
D
V
E
A
R
-
R
Q
E
--
G
--
L
-
P
E
R
V
G
-
V
V
Y
G
E
-
V
-
P
E
V
---
L
E
V
E
E
D
G
L
R
F
P
I
P
L
A
L
A
Q
K
T
G
Y
Y
L
D
Q
R
E
N
R
R
L
F
E
A
-
M
V
R
P
G
E
R
V
L
D
V
Y
S
Y
V
G
G
F
A
L
R
A
A
R
K
G
A
-
Y
A
L
A
V
D
K
D
L
E
A
L
G
V
L
D
Q
A
A
L
R
L
G
L
---
R
V
D
I
R
H
-
G
E
A
--
L
P
T
L
R
G
---
L
E
G
P
--
F
H
H
V
L
L
D
P
P
T
L
V
K
R
P
E
E
L
P
A
M
K
R
H
L
V
D
L
V
R
E
A
L
R
L
L
A
E
E
G
F
L
W
L
S
S
C
S
Y
H
L
R
L
E
D
L
L
E
V
A
R
R
A
A
A
D
L
G
R
R
L
R
V
H
R
V
T
-
Y
Q
P
E
D
H
P
W
S
L
H
I
P
E
S
L
Y
L
K
T
L
V
L
Q
D
--
3
PsiBlast_PDB
66.71
27%
12
- C1 -
2AS0
-
?
A:
[8-390]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
A
A
R
A
I
G
K
G
A
M
I
V
F
K
K
G
V
V
R
V
E
G
D
I
K
---
P
G
D
I
V
E
V
Y
T
R
-
G
G
K
F
L
G
K
G
F
A
N
P
N
S
N
I
M
V
R
I
V
T
K
D
K
D
V
E
I
N
K
D
L
F
K
R
R
I
K
K
A
N
E
Y
R
K
K
V
L
K
Y
--
T
N
V
Y
R
M
V
Y
G
E
A
D
Y
L
P
G
L
I
V
D
R
F
N
D
I
A
S
L
Q
I
S
S
-
A
G
M
E
R
F
-----
K
L
D
V
A
E
A
I
M
E
V
E
P
-
G
I
E
T
V
F
E
K
N
TG
R
S
R
R
--
R
-
E
--
G
--
L
-
P
E
I
E
R
-
V
L
L
G
K
-
E
-
K
Y
R
---
T
I
I
Q
E
G
R
A
K
F
I
V
D
M
R
-
G
Q
K
T
G
F
F
L
D
Q
R
E
N
R
L
A
L
E
K
W
V
Q
-
P
G
D
R
V
L
D
V
F
T
Y
T
G
G
F
A
I
H
A
A
I
A
G
A
D
E
V
I
G
I
D
K
S
P
R
A
I
E
T
A
K
E
N
A
K
L
N
G
V
E
D
R
M
K
F
I
-
V
-
G
S
A
--
F
E
E
M
E
K
L
Q
K
K
G
E
K
--
F
D
I
V
V
L
D
P
P
A
F
V
Q
H
E
K
D
L
K
A
G
L
R
A
Y
F
N
V
N
F
A
G
L
N
L
V
K
D
G
G
I
L
V
T
C
S
C
S
Q
H
V
D
L
Q
M
F
K
D
M
I
I
A
A
G
A
K
A
G
K
F
L
K
M
L
E
P
Y
R
T
Q
A
P
D
H
P
I
L
M
A
S
K
D
T
E
Y
L
K
C
L
F
L
----
6
PsiBlast_PDB
59.95
27%
-9
- C1 -
1WXX
4
?
A:
[70-380]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
L
L
E
N
L
A
Q
A
L
A
R
R
E
A
V
L
R
Q
D
P
E
G
G
Y
R
L
V
H
A
E
G
D
L
L
P
G
L
V
V
D
Y
Y
A
G
H
A
V
V
Q
A
T
A
----
H
A
W
-----
E
G
L
L
P
Q
V
A
E
A
L
R
P
-
H
V
Q
S
V
L
A
K
N
----
D
A
--
R
-
T
--
R
--
E
-
L
E
G
L
P
L
Y
V
R
P
L
-
L
G
E
V
P
E
R
-
V
Q
V
Q
E
G
R
V
R
Y
L
V
D
L
R
A
G
Q
K
T
G
A
Y
L
D
Q
R
E
N
R
-
L
Y
M
E
R
F
--
R
G
E
R
A
L
D
V
F
S
Y
A
G
G
F
A
L
H
L
A
L
G
F
R
E
-
V
V
A
V
D
S
S
A
E
A
L
R
R
A
E
E
N
A
R
L
N
G
L
G
----
N
V
R
V
-
L
E
A
N
A
F
D
L
L
R
R
L
E
K
E
G
E
R
--
F
D
L
V
V
L
D
P
P
A
F
A
K
G
K
K
D
V
E
R
A
Y
R
A
Y
K
E
V
N
L
R
A
I
K
L
L
K
E
G
G
I
L
A
T
A
S
C
S
H
H
M
T
E
P
L
F
Y
A
M
V
A
E
A
A
Q
D
A
H
R
L
L
R
V
V
E
K
R
-
G
Q
P
F
D
H
P
V
L
L
N
H
P
E
T
H
Y
L
K
F
A
V
F
Q
---
4
PsiBlast_PDB
59.16
27%
-15
- C1 -
2CWW
1
?
A:
[70-380]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
L
L
E
N
L
A
Q
A
L
A
R
R
E
A
V
L
R
Q
D
P
E
G
G
Y
R
L
V
H
A
E
G
D
L
L
P
G
L
V
V
D
Y
Y
A
G
H
A
V
V
Q
A
T
A
----
H
A
W
-----
E
G
L
L
P
Q
V
A
E
A
L
R
P
-
H
V
Q
S
V
L
A
K
N
----
D
A
--
R
-
T
--
R
--
E
-
L
E
G
L
P
L
Y
V
R
P
L
-
L
G
E
V
P
E
R
-
V
Q
V
Q
E
G
R
V
R
Y
L
V
D
L
------
G
A
Y
L
D
Q
R
E
N
R
L
Y
M
-
E
R
F
--
R
G
E
R
A
L
D
V
F
S
Y
A
G
G
F
A
L
H
L
A
L
G
F
R
E
-
V
V
A
V
D
S
S
A
E
A
L
R
R
A
E
E
N
A
R
L
N
G
L
G
----
N
V
R
V
-
L
E
A
N
A
F
D
L
L
R
R
L
E
K
E
G
E
R
--
F
D
L
V
V
L
D
P
P
A
F
A
K
G
K
K
D
V
E
R
A
Y
R
A
Y
K
E
V
N
L
R
A
I
K
L
L
K
E
G
G
I
L
A
T
A
S
C
S
H
H
M
T
E
P
L
F
Y
A
M
V
A
E
A
A
Q
D
A
H
R
L
L
R
V
V
E
K
R
-
G
Q
P
F
D
H
P
V
L
L
N
H
P
E
T
H
Y
L
K
F
A
V
F
Q
---
28
Fugue
59.07
24%
14
- C1 -
3V97
6
RLMKL_ECOLI
A:
[1-703]
A
M
N
S
L
F
A
S
T
A
RGL
E
E
L
L
K
T
E
L
E
N
L
GAVE
C
Q
V
V
QG
G
V
H
F
K
G
D
T
R
L
V
Y
Q
S
L
M
W
SRLAS
R
I
M
L
P
L
G
E
C
K
V
YS
D
L
D
L
Y
L
G
V
Q
AINWTEMFNPG
A
T
F
A
V
H
F
S
G
L
N
DTIRN
S
Q
Y
G
A
M
K
V
K
D
A
I
V
D
A
F
T
R
K
NLP
R
P
N
V
D
RDAPD
I
R
V
N
V
W
L
H
KE
T
A
S
I
A
L
D
LSGDGLHLRGYRDRAGIAPIK
E
T
L
A
A
A
I
V
M
R
SGWQPG
T
P
L
L
D
PMCGSG
T
L
L
I
E
A
A
M
L
A
T
DRAPGLHRGRWGFSGWAQHD
E
A
I
W
Q
E
V
K
A
E
A
Q
T
R
A
R
K
G
L
A
E
YS
S
H
F
Y
G
S
D
SD
A
R
V
I
Q
R
A
R
T
N
A
R
L
A
GIGEL
I
T
F
E
VKDVAQLTNPLPKGP
Y
G
T
V
L
S
N
P
P
Y
GESE
P
A
L
I
A
L
H
S
L
L
G
R
I
-
M
K
N
Q
F
G
G
W
N
L
S
L
F
S
A
S
P
D
L
L
S
C
L
Q
L
R
A
D
K
Q
Y
K
A
K
N
G
P
L
D
C
V
Q
K
N
Y
H
V
A
E
S
M
V
A
-------------
E
D
Y
T
N
R
L
R
K
N
L
K
K
F
E
K
W
A
R
Q
E
G
I
E
C
Y
R
L
Y
D
A
D
L
P
E
Y
N
-
V
A
V
D
R
Y
A
D
W
V
V
V
Q
E
Y
A
H
K
A
R
Q
R
L
-----
F
D
I
I
A
A
T
I
S
V
L
G
I
-
A
P
N
K
L
V
L
K
T
--
R
------------------------
E
E
-
K
G
E
F
----
L
E
V
T
E
Y
N
A
H
L
W
V
N
L
T
D
Y
L
D
T
G
L
F
L
D
H
R
I
A
R
R
M
L
G
Q
M
-
S
-
K
G
K
D
F
L
N
L
F
S
Y
T
G
S
A
T
V
H
A
G
L
G
G
A
R
S
T
T
T
V
D
M
S
R
T
Y
L
E
W
A
E
R
N
L
R
L
N
G
L
T
G
R
A
H
R
L
I
Q
-
A
D
C
--
L
A
W
L
R
E
A
N
E
---
Q
--
F
D
L
I
F
I
D
P
P
T
F
-----
S
A
F
D
V
Q
R
D
H
L
A
L
M
K
D
L
K
R
L
L
R
A
G
G
T
I
M
F
S
N
N
K
R
G
F
R
M
D
------
L
D
G
L
A
K
L
G
L
K
A
Q
E
I
T
Q
K
-
T
L
S
Q
D
F
A
R
N
R
-----
Q
I
H
N
C
W
L
I
T
A
A
-
5
PsiBlast_PDB
58.79
27%
-7
- C1 -
1WXW
-
?
A:
[70-380]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
L
L
E
N
L
A
Q
A
L
A
R
R
E
A
V
L
R
Q
D
P
E
G
G
Y
R
L
V
H
A
E
G
D
L
L
P
G
L
V
V
D
Y
Y
A
G
H
A
V
V
Q
A
T
A
----
H
A
W
-----
E
G
L
L
P
Q
V
A
E
A
L
R
P
-
H
V
Q
S
V
L
A
K
N
----
D
A
--
R
-
T
--
R
--
E
-
L
E
G
L
P
L
Y
V
R
P
L
-
L
G
E
V
P
E
R
-
V
Q
V
Q
E
G
R
V
R
Y
L
V
D
L
R
A
-----
A
Y
L
D
Q
R
E
N
R
-
L
Y
M
E
R
F
--
R
G
E
R
A
L
D
V
F
S
Y
A
G
G
F
A
L
H
L
A
L
G
F
R
E
-
V
V
A
V
D
S
S
A
E
A
L
R
R
A
E
E
N
A
R
L
N
G
L
G
----
N
V
R
V
-
L
E
A
N
A
F
D
L
L
R
R
L
E
K
E
G
E
R
--
F
D
L
V
V
L
D
P
P
A
F
A
K
G
K
K
D
V
E
R
A
Y
R
A
Y
K
E
V
N
L
R
A
I
K
L
L
K
E
G
G
I
L
A
T
A
S
C
S
H
H
M
T
E
P
L
F
Y
A
M
V
A
E
A
A
Q
D
A
H
R
L
L
R
V
V
E
K
R
-
G
Q
P
F
D
H
P
V
L
L
N
H
P
E
T
H
Y
L
K
F
A
V
F
Q
---
36
HHSearch
52.85
25%
-2
- C1 -
3V97
3
RLMKL_ECOLI
A:
[393-697]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
D
Y
T
N
R
L
R
K
N
L
K
K
F
E
K
W
A
R
Q
E
G
I
E
C
Y
R
L
Y
D
A
D
L
P
E
Y
-
N
V
A
V
D
R
Y
A
D
W
V
V
V
Q
E
Y
A
------
H
K
A
R
Q
R
L
F
D
I
I
A
A
T
I
S
V
L
G
I
A
P
N
K
L
V
L
K
T
--
R
E
------------------------
E
-
K
-
G
E
F
---
L
E
V
T
E
Y
N
A
H
L
W
V
N
L
T
D
Y
L
D
T
G
L
F
L
D
H
R
I
A
R
R
M
L
G
Q
-
M
S
-
K
G
K
D
F
L
N
L
F
S
Y
T
G
S
A
T
V
H
A
G
L
G
G
A
R
S
T
T
T
V
D
M
S
R
T
Y
L
E
W
A
E
R
N
L
R
L
N
G
L
T
G
R
A
H
R
L
I
Q
-
A
D
C
--
L
A
W
L
R
E
---
A
N
E
Q
--
F
D
L
I
F
I
D
P
P
T
F
S
-----
A
F
D
V
Q
R
D
H
L
A
L
M
K
D
L
K
R
L
L
R
A
G
G
T
I
M
F
S
N
N
K
R
G
F
R
M
D
------
L
D
G
L
A
K
L
G
L
K
A
Q
E
I
T
Q
K
-
T
L
S
Q
D
F
A
R
N
R
Q
I
H
N
C
------------