@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu39000: (2016-08-05 )
MELIIILLALGLLMFTAYRGFSVILFAPICALFAVLLTDPSHVLPFFSSIFMEKMAGFIKLYFPVFLLGAIFGKVVEMAGLAASIAKTIVRLVGAKRAILAIVLMGAVLTYSGVSLFVVVFAVYPFAKNMFQEANIPKRLIPGTIALGAFTFTMDALPGTPQIQNVIPTSFFKTDIYAAPWLGLMGAVIVLAAGMLYLESRRKKAQASGEGYGGFDSQNAPAPESIESAAEPDKSPIRHALAFVPLILVGAVNKYFTIYLPKWYPNGFDFSSIGLKEFGRLDISSAAAIWSVEIALVIGIITTILFDWRSVFAQLKEGLNEGIGGALLASMNTGAEYGFGGIIAALPGFHKLSSGISHTFTDPLVNGAVTTTALAGITGSASGGMGIALSAMSEQYLQAIQAYNIPPEVMHRVISMASGGMDTLPHNGAVITLLAVTGLTHRQSYRDIFAITLIKTAAVFAVIAIYSLTGLV
Atome Classification :
(20 SA)
---------------------------------.........10--........20........30......--..40....---....50..---......60........70........80..-----.-.....90.-...-.---.--..--100------------------------......-------..110--------------------...-.....120.......130....----...-----------140---.........--------------------150...---....-160......----.-------170.-------.-....------.180.......---190.......200.------....-----..210.......220.......230----.........240---....---...250.......260....----------...-270......-.280.......290.......300.---...---..--.310-........320--...---..----....330--..---....-.340.......350.--------.......--360....---..---..370.......380..---------------.....390.......400-........410-------....------....420....-....430......-----.440---.........450....------..-.----460.....--------------------..470------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------M
E
L
I
I
I
L
L
A
L
G
--
L
L
M
F
T
A
YRG
F
S
V
I
L
F
A
P
I
C
A
L
F
A
V
L
L--TD
P
S
H
V
L
P
---
F
F
S
S
I
F
M
E
---
K
M
A
G
F
I
K
L
Y
F
P
V
F
L
L
G
A
I
F
G
K
V
V
E
M
A
G
L
A
A
-----
S
-
I
A
K
T
I
V
R
L
-VG
A
-
K
---
R
--
A
I
--
L
A
-------------------------
I
V
L
M
G
A
-------
V
L
T
Y---------------------S
G
V
-
S
L
F
V
V
V
F
A
V
Y
P
F
A
K
N
M
F
Q
EANI----
P
K
R
-----------L-----IPG
T
I
A
L
G
A
--------------------
F
T
F
T
MD---ALPG-TP
Q
I
Q
NVIP----T-------SFFK-------T-DIYA------
A
P
W
L
G
L
M
G
A
V
I
---
V
L
A
A
G
M
L
Y
L
E
S
R
R
K
------
K
AQA-----SGEGYGGFDSQNAPA
P
E
S
I
E
S
AA------EP
D
K
S
P
I
R
H
A
L
A
---
F
V
P
L
---
I
L
V
GAVN
K
Y
F
T
I
Y
LPKWYPN----------GF
D
-
F
S
S
I
G
L
K
E
F-GRLDISSA
A
A
I
W
S
V
E
I
A
L
V
I
G
I
I
T
T
---
I
L
F
---
D
W
--
R
S
V
--
F
A
Q
L
K
E
G
L
N
----EGI---
G
G
----
A
L
L
A
SMN--TG---AEYG-F
G
G
I
I
A
ALP
G
F
H
K
-
L
--------
S
SGISHT--FT-DPLV---NG---A
V
T
T
T
A
L
AGITGSASGG---------------
M
G
I
A
L
S
A
M
S
E
Q
Y
L
Q
A
I
Q
--AYNI
P
P
E
V
M
H
--------
R
V
I
S
------
M
ASGG-MDTLP-HN
G
A
V
I
T
L
L
A
VTG-----LT-----
H
R
Q
S
Y
R
D
I
F
A
I
T
L
I
K
T
------
A
A
-
V
----
F
A
V
I
A
I
Y
S
--------------------
L
TGLV------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Fugue
76.82
17%
-127
- C3 -
4WGV
-
?
A:
[45-439]
---------------------------------
V
G
Y
M
D
P
G
N
W
I
T
--
S
M
Q
G
G
A
Q
Y
G
Y
T
L
L
F
V
I
L
I
S
S
L
A
A
M
L
L
--
Q
S
M
T
V
R
L
G
---
I
A
T
G
K
D
L
A
---
Q
M
T
R
----
H
F
L
S
K
P
V
A
I
I
F
W
I
I
A
E
L
A
I
I
A
T
-----
D
-
I
A
E
V
I
G
S
A
-
I
A
L
-
D
---
L
--
I
F
--
G
I
-------------------------
P
L
I
V
G
A
-------
L
I
T
---------------------------
V
F
D
V
F
L
L
L
F
I
M
R
F
G
F
R
K
I
E
A
I
----
V
G
T
-----------
L
-----
I
F
T
V
L
A
I
F
V
--------------------
F
E
V
F
I
S
---
S
P
Q
L
-
T
D
I
L
N
G
F
V
P
----
H
-------
K
E
I
V
-------
T
N
Q
G
I
L
------
Y
I
A
L
G
I
I
G
A
T
I
---
M
--
P
H
N
L
Y
L
H
S
S
I
V
------
Q
S
R
K
-----
Y
D
R
------
H
D
N
E
E
K
A
Q
A
I
K
Y
A
T
------
I
D
S
N
L
Q
L
S
I
A
F
V
---
V
N
C
L
---
L
L
T
L
G
A
A
L
F
F
--------------------
G
T
K
-
T
N
D
L
G
---------------------------------------
G
F
--
Y
D
L
--
Y
H
A
L
K
---
T
----
E
P
V
---
L
G
----
A
----------------
T
-
L
G
G
V
M
S
T
L
F
A
V
A
L
-
L
--------
A
S
G
Q
N
S
T
--
I
T
-
G
T
L
A
----
G
---
Q
I
V
M
E
G
F
L
R
L
S
I
P
N
W
L
R
---------------
R
L
I
T
R
S
L
A
V
I
P
V
I
I
C
L
I
--
I
F
K
G
N
S
E
K
I
E
--------
Q
L
L
V
------
F
S
Q
V
F
-
L
S
I
A
L
-
P
F
S
L
I
P
L
Q
L
A
T
S
N
-----
K
K
-----
L
M
G
P
F
I
N
K
T
W
V
N
I
I
S
W
------
T
L
-
I
----
V
I
L
S
G
L
N
V
--------------------
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Fugue
65.82
20%
-92
- C3 -
4P5F
1
?
A:
[8-374]
---------------------------------
L
T
P
T
E
A
A
V
L
R
E
--
L
R
L
H
R
P
Q
L
P
L
D
T
L
L
F
T
D
P
N
---------
K
D
P
D
D
V
V
T
---
Y
T
I
A
K
Q
L
Q
---
A
-
D
G
F
L
R
L
T
D
V
V
V
T
L
G
D
-----
A
D
M
R
S
Q
R
A
-----
Q
-
L
A
K
G
V
F
D
R
-
L
A
L
-
P
---
D
------------------------------------------------------------------------------
V
R
V
A
R
G
Q
D
Y
P
M
T
S
T
Q
A
R
E
H
----
S
K
F
-----------
L
-----
A
E
G
A
A
L
R
A
A
--------------------
P
D
A
V
H
T
-----
D
G
-
V
R
A
M
C
E
R
L
A
----
T
-------
S
P
H
K
-------
L
-
G
M
V
V
------
I
A
--
G
M
T
D
A
S
A
---
L
L
A
E
A
G
D
L
V
R
E
K
V
A
------
S
I
T
I
-----
M
G
----
G
I
D
P
A
R
D
A
-----
D
G
L
V
------
Q
P
D
T
R
A
Y
N
N
A
T
----------------------------------------------------------
D
I
H
A
A
R
A
L
Y
R
R
A
Q
Q
L
--
G
I
P
L
R
---
I
L
T
---
K
E
--
A
A
Y
--
K
A
A
V
P
P
A
F
Y
----
E
G
I
A
R
N
G
H
----
P
V
G
E
Y
L
R
--
D
V
---
Q
K
N
A
-
L
K
G
L
W
E
G
I
Q
A
-
N
L
-
I
--------
P
G
L
D
T
A
W
--
F
F
-
R
T
F
V
---
A
G
---
A
L
S
F
D
A
I
W
P
Q
V
T
K
L
N
L
Y
---------------
D
P
L
T
L
L
A
A
L
P
G
T
A
R
L
L
------
F
Q
P
T
P
M
H
--------
R
------------
E
G
-
A
S
P
V
E
-
H
V
G
----------------------
H
A
E
V
V
R
P
E
K
A
R
L
L
L
S
A
------
L
A
-
K
----
A
A
L
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Fugue
64.41
16%
-46
- C1 -
4UI9
-
APC5_HUMAN
O:
[27-756]
----------------------------KDWVT
P
Y
K
I
A
V
L
V
L
L
S
--
E
M
S
R
T
G
E
G
A
V
S
L
V
E
R
R
R
L
N
Q
Q
L
L
P
L
L
--
Q
G
P
D
I
T
V
S
---
K
L
L
K
L
I
E
E
SCP
Q
L
A
N
S
V
Q
I
R
I
K
L
M
A
E
G
E
L
K
D
M
E
Q
F
F
D
D
L
S
D
-----
S
-
F
S
G
T
--
E
P
-
E
V
H
-
K
---
T
--
S
V
--
V
G
-------------------------
L
F
L
R
H
M
-------
I
L
A
Y
---------------------
S
K
L
-
S
-
F
S
Q
V
F
K
L
Y
T
A
L
Q
Q
Y
F
Q
S
D
E
N
KKPL
S
Q
K
-----------
Q
-----
A
E
F
F
L
S
Q
Q
A
--------------------
S
L
L
K
N
D
ETK
A
L
T
P
-
A
S
L
Q
K
E
L
N
N
----
L
-------
L
K
F
N
-------
P
-
D
F
A
E
------
A
H
Y
L
S
Y
L
N
N
L
R
VQD
V
F
S
S
T
H
S
L
L
H
Y
F
D
R
LILTGA
E
S
K
S
-----
N
G
E
E
G
Y
G
R
S
L
R
Y
A
A
L
N
L
A
A
L
H
C
R
------
F
G
H
Y
Q
Q
A
E
L
A
L
Q
---
E
A
I
R
---
I
A
Q
E
S
N
D
H
V
C
L
Q
H
C
L
S
W
L
Y
V
LGQKRSDSYV
L
L
E
-
H
S
V
K
K
A
V
H
F
-
G
L
P
Y
L
A
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L
G
I
Q
S
L
V
Q
Q
R
A
F
A
G
K
T
A
N
---
K
L
M
---
D
A
LK
D
S
D
--
L
L
H
W
K
H
S
L
S
----
E
L
I
---
D
I
----
S
I
A
Q
K
T
A
--
I
W
---
R
L
Y
G
R
S
T
M
A
L
Q
Q
A
Q
M
L
L
S
-
M
--------
N
S
L
E
Q
Q
N
--
N
T
-
E
S
F
A
---
V
A
---
L
C
H
L
A
E
L
H
A
E
Q
G
C
F
A
A
A
SEVLKHLKERFPPNS
Q
H
A
Q
L
W
M
L
C
D
Q
K
I
Q
F
D
R
--
A
M
N
D
G
K
--
Y
H
--------
L
A
D
S
------
L
V
T
G
I
-
T
A
L
N
S
-
I
E
G
V
Y
R
K
A
V
V
L
Q
A
-----
Q
N
-----
Q
M
S
E
A
H
K
L
L
Q
K
L
L
V
H
C
------
Q
K
-
L
KNTE
M
V
I
S
V
L
L
S
--------------------
V
A
E
L
Y
WRSSSPTIALPMLLQALALSKEYRLQYLASETVLNLAFAQLILGIPEQALSLLHMAIEPILADGAILDKGRAMFLVAKCQVASAASYDQPKKAEALEAAIENLNEAKNYFAKVDCKERIRDVVYFQARLYHTLGKTQERNRCAMLFRQLHQELPSVPLINHL
20
Fugue
59.65
13%
-116
- C3 -
3PJZ
1
TRKH_VIBPA
A:
[1-484]
---------------------------------
M
Q
F
R
S
I
I
R
I
V
G
--
L
L
L
A
L
F
S
V
T
M
-------
L
A
P
A
L
V
A
L
L
--
Y
R
D
G
A
G
V
P
---
F
V
T
T
F
F
V
L
---
L
F
C
G
A
--------
M
C
W
F
P
N
R
R
H
K
H
E
L
K
S
R
D
-----
G
-
F
L
I
V
V
L
F
W
-
T
V
L
-
G
---
S
--
A
G
--
S
L
-------------------------
P
F
L
I
A
D
-------
N
P
N
I
---------------------
S
V
T
-
D
A
F
F
E
S
F
S
A
L
T
T
T
G
-----
A
T
V
----
I
V
G
-----------
L
-----
D
E
L
P
K
A
I
L
F
--------------------
Y
R
Q
F
L
Q
---
W
F
G
G
-
M
G
I
I
V
L
A
V
A
----
I
LPVLGIG
G
M
T
P
-------
R
-
I
A
E
T
------
A
K
A
L
W
Y
I
Y
L
S
L
---
T
I
A
C
A
V
A
F
W
L
A
G
M
T
------
P
F
D
A
I
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H
S
F
S
T
I
A
I
G
G
F
S
T
H
D
A
-------
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M
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------
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F
D
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Y
A
I
N
L
I
T
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---
V
F
L
L
---
I
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C
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F
A
A
F
A
S
G
--------------------
G
V
H
P
K
Y
Y
-
W
K
---
D
P
E
F
R
A
F
I
F
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L
L
F
L
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C
F
L
---
L
L
L
---
K
---
H
H
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Y
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A
F
D
----
Q
A
L
---
F
Q
----
T
V
S
I
S
T
T
--
A
G
FTT
T
G
F
A
-
D
W
P
L
F
L
P
V
L
L
L
F
S
-
S
F
I
GGCAGS
T
G
G
G
M
K
V
--
I
R
-
I
L
L
L
---
T
L
---
Q
G
A
R
E
L
K
R
L
V
H
P
R
A
V
Y
T
---------------
I
K
V
G
G
S
A
L
P
Q
R
V
V
D
A
V
W
G
F
F
S
A
Y
A
L
V
F
V
V
--------
C
M
L
G
------
L
I
A
T
G
-
M
D
E
L
S
-
A
F
S
A
V
A
A
T
L
N
N
L
G
PGLGE
V
A
-----
L
H
F
G
D
V
N
D
K
A
K
W
V
L
I
V
------
S
M
-
L
----
F
G
R
L
E
I
F
T
--------------------
L
L
I
L
L
TPTFWR------------------------------------------------------------------------------------------------------------------------------------------------------------
13
HHSearch
59.65
14%
-116
- C5 -
4R0C
6
?
A:
[72-488]
-----------------------------------------------------------------------------------------
T
L
V
G
---
N
F
T
G
F
A
P
-
L
G
-
V
V
L
V
A
M
L
G
L
G
V
A
E
Q
S
G
L
L
S
-----
V
-
S
L
A
S
L
V
R
R
-
S
S
G
-
G
---
A
--
L
---
V
F
-------------------------
T
V
A
F
A
G
-------
V
L
-----------------------
S
S
L
-
T
V
D
A
G
Y
V
V
L
I
P
L
A
G
L
V
F
Q
L
A
G
R
----
P
P
I
-----------
A
-----
G
I
A
T
A
F
A
A
V
--------------------
S
-
G
G
F
S
---
A
N
L
L
V
G
P
V
--
D
A
T
L
A
G
L
S
T
-------
E
A
A
H
I
IDPD
R
T
V
-
A
A
T
G
------
N
Y
W
F
I
I
A
S
T
F
L
---
V
T
G
L
V
T
L
I
T
R
T
-
L
T
------
E
-
P
R
-----
L
A
H
A
N
T
V
A
D
A
-----
S
V
D
A
P
Q
I
H
------
S
R
-----
A
M
K
W
T
G
L
T
L
A
I
L
---
L
A
G
L
A
L
L
V
-----
L
P
-
N
D
-
A
----------
P
L
R
H
P
D
T
G
------
S
-
V
L
G
S
P
F
----
I
H
G
L
V
V
I
V
A
L
I
A
G
---
I
C
G
A
V
Y
G
R
V
S
G
Q
F
RN
S
G
A
V
I
T
A
M
E
----
V
T
M
---
A
S
----
M
A
G
Y
L
V
L
--
M
F
---
F
A
A
Q
-
F
V
A
W
F
N
Y
S
Q
L
G
L
L
L
A
--------
V
K
G
A
A
W
L
G
A
L
T
V
P
K
V
V
L
L
L
L
F
---
V
V
L
T
A
L
I
N
L
M
I
G
S
A
S
A
K
---------------
W
S
I
L
A
P
V
F
I
P
M
L
M
------
L
L
G
I
S
P
E
A
S
Q
--------
A
A
Y
R
------
V
G
D
S
S
T
N
I
I
T
P
-
L
M
P
Y
F
V
L
V
L
G
F
A
R
-----
R
Y
QPETG
I
G
T
L
I
A
L
M
L
P
Y
S
L
T
L
L
------
L
G
W
S
-----
V
L
L
G
V
W
I
--------------------
G
F
G
W
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
HHSearch
57.20
13%
-115
* C5 *
4F35
2
?
D:
[48-449]
----------------------------------------------------
T
E
A
L
H
V
T
V
T
A
I
L
V
P
V
M
A
V
F
F
--
G
-
I
---
F
E
---
T
Q
A
--------
A
L
N
N
F
A
N
S
I
I
F
L
F
L
G
G
F
A
L
A
A
A
M
H
H
Q
G
L
D
K
-----
V
-
I
A
D
K
V
L
A
M
-
A
Q
G
-
K
M
S
-
V
--
A
V
--
F
M
-------------------------
L
F
G
V
T
A
-------
L
L
S
M
----------------------
W
I
-
S
N
T
A
T
A
A
M
M
L
P
L
V
L
G
V
L
S
K
V
D
A
----
D
K
Q
-----------
R
STYVF
V
L
L
G
V
A
Y
S
A
--------------------
S
I
G
G
I
A
---
T
L
V
G
-
S
P
P
--
N
A
I
A
----
A
-------
A
E
V
G
-------
L
-
S
F
T
D
------
W
M
K
F
G
L
P
T
A
M
M
---
M
L
P
M
A
I
A
I
L
Y
F
L
L
------------------------------------
V
N
W
------
D
K
-----
G
K
V
V
T
---
L
G
I
F
---
G
L
T
V
F
L
W
I
-----
F
S
S
P
I
-
N
----------
A
A
L
-----------
G
G
F
----
K
S
F
--
D
T
L
V
A
-
L
G
A
I
L
M
L
---
S
F
A
---
R
V
--
V
H
-------
W
K
E
I
Q
----
K
T
A
---
D
------
W
G
V
L
L
L
--
F
G
---
G
G
L
C
-
L
S
N
V
L
K
Q
T
G
T
S
V
F
-
L
--------
A
N
A
L
S
D
M
V
-
S
H
M
G
I
F
V
---
V
I
L
V
V
A
T
F
V
V
F
L
T
-
E
F
A
S
N
T
A
S
-------------------
A
A
L
L
I
P
V
F
A
T
V
A
E
--
A
F
G
M
S
P
V
L
L
S
--------
V
L
I
A
------
V
A
A
S
C
-
A
F
M
L
P
V
A
T
P
P
N
A
I
V
F
A
S
G
H
-----
I
K
-----
Q
S
E
M
M
R
V
G
L
Y
L
N
I
A
C
I
------
G
L
L
T
----
A
I
A
M
L
F
W
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Fugue
53.99
17%
-49
- C3 -
3JA7
-
PORTL_BPT4
A:
[70-516]
------------------------------N
W
I
S
E
L
I
D
T
Y
R
N
L
---------
M
N
N
Y
E
V
D
N
A
V
S
E
I
V
S
D
A
I
V
Y
--
E
D
D
T
E
V
V
A
---
L
--
N
L
D
K
S
---
K
F
S
P
K
I
K
N
-----
M
M
L
D
E
F
S
D
V
L
N
H
L
S
F
Q
R
-----
K
-
G
S
D
H
F
R
R
W
-
Y
V
D
-
S
---
R
--
I
F
--
F
H
-------------------------
K
I
I
D
P
K
RPKEGI
K
E
L
R
R
---------------------
L
D
P
-
R
Q
V
Q
Y
V
Y
F
I
Y
D
T
A
H
E
S
Y
----------------------------------
A
C
D
G
--------------------
R
M
Y
E
A
G
---
T
K
I
K
-
I
P
K
-
A
A
V
V
Y
----
A
-------
H
S
G
L
-------
V
-
D
C
C
G
------
K
N
I
I
G
Y
L
H
R
A
V
---
K
P
A
N
Q
L
K
L
L
E
D
A
V
V
------
I
Y
R
I
-----
T
R
------------
A
P
D
R
R
V
W
Y
V
------
D
T
G
N
M
P
A
R
K
A
A
E
---
H
M
Q
H
---
V
M
N
T
M
K
N
R
V
V
Y
D
A
S
T
G
K
I
K
N
----------
Q
Q
H
-
N
M
S
M
T
E
D
Y
W
L
Q
R
R
D
G
K
A
V
T
E
V
D
T
L
P
G
A
D
N
T
G
N
M
E
D
---
I
R
W
---
F
R
--
Q
A
L
--
Y
M
A
L
R
V
P
L
S
RIPQ
D
Q
Q
---
G
G
----
V
M
F
D
S
G
T
SI
T
R
---
D
E
L
T
-
F
A
K
F
I
R
E
L
Q
--
H
K
-
F
--------
E
----
E
V
--
F
L
-
D
P
L
K
---
T
N
---
L
L
L
K
G
I
I
T
E
D
E
W
N
D
E
I
N
----------------
N
I
K
I
E
F
H
R
D
S
Y
F
A
E
L
K
------
E
A
E
I
L
E
--------
R
R
I
N
------
M
L
T
M
A
-
E
---
P
-
F
I
G
K
Y
I
S
------------------
H
R
T
A
M
K
D
I
L
Q
M
T
D
E
E
I
------
E
Q
-
E
----
A
K
Q
I
E
E
E
S
--------------------
K
E
A
R
F
QD----------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Fugue
52.48
18%
-16
- C3 -
3WOL
10
DAPB2_PSEMX
A:
[1-696]
GEGMWVPQQLPEI
A
G
P
L
K
K
A
GLKLS
P
Q
Q
I
S
DLT
G
D
P
M
G
A
V
V
A
L
G
G
C
T
A
S
F
V
S
P
N
G
--
L
V
V
T
N
H
H
C
A
Y
G
A
I
Q
L
N
S
T
A
E
N
N
L
I
K
N
G
F
N
A
P
T
T
A
D
E
---
V
S
A
G
P
N
A
---
R
V
F
V
L
D
E
I
T
D
V
T
K
D
A
K
A
A
I
A
A
A
GDD
A
-
L
A
R
T
K
A
L
E
-
A
F
E
-
K
---
K
--
L
I
--
A
D
C
E
AEAG
F
R
C
R
L
Y
S
F
SGGN
T
Y
R
L
F
K
N
L
E
I
K
D
V
-------
R
L
A
Y
A
P
P
G
S
V
G
K
FGGDIDNWMWPRH
T
G
D
-
F
A
F
Y
R
A
Y
V
G
K
D
G
K
P
A
A
F
S
K
D
N
V
----
P
Y
Q
P
K
H
W
L
K
F
A
D
Q
P
L
-----
G
A
G
D
F
V
M
V
A
G
Y
P
G
S
TNRYAL
A
A
E
F
D
N
T
A
Q
W
T
Y
P
T
I
---
A
R
H
Y
-
K
N
Q
I
A
M
V
E
A
----
A
-------
G
K
Q
N
-------
A
-
D
I
Q
V
K
Y
A
A
T
M
A
G
W
N
N
T
S
K
N
Y
D
---
G
Q
L
E
G
F
K
R
I
D
A
A
G
Q
------
K
L
R
E
-----
E
A
A
V
L
G
W
L
K
G
Q
G
A
K
G
Q
P
A
L
D
A
H
A
K
L
L
D
L
L
E
Q
S
K
A
T
R
D
R
D
L
T
---
L
A
L
F
N
N
T
A
M
L
G
S
A
T
Q
L
Y
R
L
S
I
E
R
E
K
P
N
----------
A
E
R
-
E
S
G
Y
Q
E
R
D
L
-
P
A
I
E
G
G
L
K
Q
L
E
R
R
Y
V
A
A
M
D
R
Q
L
Q
E
Y
---
W
L
N
---
E
Y
--
I
K
L
P-
A
D
Q
R
V
A
A
V
D
----
A
W
L
---
G
G
ND
A
A
A
V
K
R
A
L
D
--
R
L
---
A
G
T
K
-
L
G
S
T
E
E
R
L
K
W
F
A
A
-
D
--------
R
K
A
F
E
A
S
---
N
-
D
P
A
I
---
Q
Y
---
A
V
A
V
M
P
T
L
L
K
L
E
Q
E
R
K
T
---------------
R
A
G
E
N
L
A
A
R
P
V
Y
L
Q
A
L
A
--
D
Y
K
K
S
Q
G
E
F
V
Y
P
DANL
S
L
R
I
T
F
G
N
V
M
G
Y
A
P
K
D
G
-
M
E
Y
T
P
-
F
T
T
L
E
G
V
V
A
K
E
T
G
-----
Q
D
-----
P
F
D
S
P
K
A
L
L
D
A
V
A
A
K
R
YGGLED
K
R
-
I
----
G
S
V
P
V
N
Y
L
S
D
L
D
I
T
GGNSG
S
P
V
L
D
AHGK
L
V
G
L
A
F
DGNWESVSSNWVFDPKM
T
R
M
I
A
V
D
G
R
Y
L
R
W
I
M
Q
EVYPA
P
Q
L
L
K
E
M
NV------------------------------------------------------------------------------------------------------------------
11
PsiBlast_CBE
44.27
37%
-165
- C4 -
1RV8
1
?
B:
[10-49]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
------
K
A
R
E
-----
E
G
Y
G
V
G
A
F
N
V
N
N
M
E
F
L
Q
A
V
L
E
A
A
------
E
E
Q
R
S
P
V
I
L
A
L
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_CBE
43.95
37%
-161
- C4 -
1RVG
1
?
C:
[10-49]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
------
K
A
R
E
-----
E
G
Y
G
V
G
A
F
N
V
N
N
M
E
F
L
Q
A
V
L
E
A
A
------
E
E
Q
R
S
P
V
I
L
A
L
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
43.51
37%
-144
- C4 -
1RVG
1
?
A:
[10-55]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
------
K
A
R
E
-----
E
G
Y
G
V
G
A
F
N
V
N
N
M
E
F
L
Q
A
V
L
E
A
A
------
E
E
Q
R
S
P
V
I
L
A
L
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_CBE
43.48
37%
-155
- C4 -
1RVG
1
?
B:
[10-49]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
------
K
A
R
E
-----
E
G
Y
G
V
G
A
F
N
V
N
N
M
E
F
L
Q
A
V
L
E
A
A
------
E
E
Q
R
S
P
V
I
L
A
L
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
43.11
37%
-152
- C4 -
1RV8
1
?
A:
[10-57]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
------
K
A
R
E
-----
E
G
Y
G
V
G
A
F
N
V
N
N
M
E
F
L
Q
A
V
L
E
A
A
------
E
E
Q
R
S
P
V
I
L
A
L
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_CBE
42.55
37%
-162
- C4 -
1RV8
1
?
D:
[10-49]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
------
K
A
R
E
-----
E
G
Y
G
V
G
A
F
N
V
N
N
M
E
F
L
Q
A
V
L
E
A
A
------
E
E
Q
R
S
P
V
I
L
A
L
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Fugue
42.46
8%
-122
- C2 -
5D0N
2
?
A:
[113-413]
--------------------------------------------------------------------------------------------------------------------------
D
V
C
E
-----
A
-
A
G
K
A
I
Y
I
V
-
S
D
G
-
T
---
G
--
W
T
--
A
E
-------------------------
H
S
V
N
A
A
-------
L
G
Q
F
---------------------
E
N
C
-
L
A
D
R
G
C
A
V
N
T
H
L
F
S
L
I
D
D
M
D
R
L
----
I
E
V
-----------
I
-----
K
Q
A
A
K
E
G
A
L
--------------------
V
L
Y
T
L
A
--------
D
P
S
M
A
E
A
T
K
----
K
-------
A
C
D
F
-------
W
-
G
V
---------
P
C
T
D
V
L
R
P
T
V
---
E
A
I
A
S
H
I
G
V
A
P
S
G
I
------
P
R
S
S
-----
P
S
-
R
N
G
R
L
S
E
D
Y
F
Q
R
I
D
A
I
D
F
T
I
------
K
Q
D
D
G
A
L
P
Q
N
L
Y
---
R
A
D
I
---
V
L
A
G
V
S
R
T
G
K
T
P
L
S
I
Y
L
A
Q
K
----------
G
Y
K
-
V
A
N
V
P
I
V
-----
M
G
V
D
L
P
K
S
L
F
E
I
N
Q
D
K
V
F
G
L
T
I
N
PAI
E
M
D
---
H
V
--
R
Q
E
--
L
V
H
A
N
Q
I
F
A
----
Q
N
P
---
S
W
----
P
V
I
A
V
T
G
--
K
A
---
I
E
E
T
-
A
A
V
I
L
G
I
L
H
D
R
K
Q
-
K
--------
C
S
M
P
R
I
S
--
K
R
-
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
41.77
42%
-94
- C4 -
2FJK
1
ALF_THECA
A:
[10-44]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
------
K
A
R
A
-----
E
G
Y
G
V
G
A
F
N
T
N
N
M
E
F
T
Q
A
I
L
E
A
A
------
E
E
M
K
S
P
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_CBE
40.51
37%
-133
- C4 -
1RVG
1
?
D:
[10-49]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
------
K
A
R
E
-----
E
G
Y
G
V
G
A
F
N
V
N
N
M
E
F
L
Q
A
V
L
E
A
A
------
E
E
Q
R
S
P
V
I
L
A
L
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_CBE
40.46
37%
-136
- C4 -
1RV8
1
?
C:
[10-49]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
------
K
A
R
E
-----
E
G
Y
G
V
G
A
F
N
V
N
N
M
E
F
L
Q
A
V
L
E
A
A
------
E
E
Q
R
S
P
V
I
L
A
L
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
HHSearch
37.30
15%
-178
- C5 -
4R1I
-
?
A:
[358-458]
---------------------------------------------------------------------------------------------------------
L
V
I
I
F
F
A
A
Q
F
V
A
F
F
N
W
T
N
I
G
Q
-----
Y
-
I
A
V
K
G
A
V
F
-
L
K
E
-
V
GLA
G
--
S
V
L
F
I
G
-------------------------
F
I
L
I
C
A
-------
F
I
N
L
----------------------
M
I
G
S
A
S
A
Q
W
A
V
T
A
P
I
F
V
P
M
L
M
L
A
G
Y
----
A
P
E
-----------
V
-----
I
Q
A
A
Y
R
I
G
D
--------------------
S
-
V
T
N
I
---
I
T
P
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
35.12
17%
-130
- C5 -
4R0C
1
?
A:
[327-440]
------------------------------------------------------------------------------------------
M
E
V
---
T
M
A
S
M
A
-
G
Y
L
V
L
M
F
F
A
A
Q
F
V
A
W
F
N
Y
S
Q
L
G
L
-----
L
L
A
V
K
G
A
A
W
L
G
A
L
T
V
P
---
K
V
V
L
L
--
L
L
-------------------------
F
V
V
L
T
A
-------
L
I
N
L
---------------------
M
I
G
-
S
A
S
A
K
W
S
I
L
A
P
V
F
I
P
M
L
M
L
L
G
I
----
S
P
E
-----------
A
-----
S
Q
A
A
Y
R
V
G
D
--------------------
S
-
S
T
N
I
---
I
T
P
L
-
M
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------