@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu39110: (2016-08-05 )
MSHFKNYQISHDILRALEGLGYTEPTKVQQSVIPAALERKDLVVKSQTGSGKTASFGIPLCELANWDENKPQALILTPTRELAVQVKEDITNIGRFKRIKATAVFGKSSFDKQKAELKQKSHIVVGTPGRVLDHIEKGTLPLDRLSYLVIDEADEMLNMGFIEQVEAIIKHLPTERTTMLFSATLPQDIEKLSRQYMQNPEHIEVKAAGLTTRNIEHAVIQVREENKFSLLKDVLMTENPDSCIIFCRTKEHVNQLTDELDDLGYPCDKIHGGMIQEDRFDVMNEFKRGEYRYLVATDVAARGIDIENISLVINYDLPLEKESYVHRTGRTGRAGNKGKAISFVTAFEKRFLADIEEYIGFEIQKIEAPSQEEVARKKPEFLAKLNDRPESKKDKSEELNKDIMKLYFNGGKKKKIRAVDFVGTIAKIDGVSADDIGIITIMDNASYVEILNGKGPHVLKVMKNTTVKGKQLKVNKANK
Atome Classification :
(66 SA)
.........10......-..20........30.......--.--40........50........60.----------..---...------------------.---------.---70-------...-......80........90...-.-.-.----.---.100........110.....-..120.-........130...-.--.-.---.140.--......150.....-..-160........170-.----.-------..--....180.......190.......200....-..----.210--.....-....220-.-.-.-.-.----.----.230....-.----------.-.240-.......250.......260.---......270.......280.......290.......300.......310.......------320-----........330.......340..---.-...-.350........360........370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSHFKNYQ
I
S
H
D
I
L
R
A
L
-
E
GLGYTEP
T
K
V
Q
Q
S
V
I
P
A
A
LE--R--K
D
L
V
V
KSQTGSGKTASFGI
P
L
C
E
----------LA---NWD------------------E---------N---K--------P
Q
A
-
L
I
LTP
T
R
E
L
A
V
Q
V
K
E
D
I
T
NIG-R-
F
-
K
----
R
---
I
K
-
A
T
A
V
FGKSSF
D
K
Q
K
A
E
L
-KQK--S-
H
I
V
VGT
P
G
R
V
L
D
H
I
-
E
--K-G---TL
P
L
D
--
R
L
S
Y
L
V
IDE
A
D
E
M
L
-
N
M
-
G
-
F
I
E
Q
V
E
A
I
I
K
H--L----P-------TE--R
T
T
M
L
F
SATL
P
Q
D
I
E
K
L
S
R
Q
Y
MQNP
E
H
I
E
V
K
-AA----GL----TTRNI-
E
H
A
V
I
Q
V
-R-E-E-
N
-
K
----
F
----
S
L
L
K
D
V
L
M-T----------E-NPD
S
-
C
I
I
F
CR
T
K
E
H
V
N
Q
L
T
D
E
L
D
DL---GY
P
C
D
K
IHGGMI
Q
E
D
R
F
D
V
M
N
E
FKRG
E
Y
R
Y
L
V
ATDVAARGI
D
I
E
N
I
S
L
V
I
N
YDLPL------EK------
E
S
Y
V
HRTGRTGRAGNKG
K
A
I
S
F
V
---
T
-
A
F
E
-
K
R
F
-
L
A
D
I
E
E
Y
IG-
F
E
I
Q
KIEAP
S
Q
E
E
V
A
R
K
K
P
E
F
L
A
K
LNDRPESKK
D
K
S
E
E
L
N
K
D
I
M
K
L
Y
FNGGK
K
K
K
I
R
A
V
D
F
V
G
T
I
A
KIDGVSAD
D
I
G
I
I
T
I
MDNA
S
Y
V
E
I
LNGKG
P
H
V
L
K
V
MKNTTVKG
K
Q
L
K
VNKANK
24
PsiBlast_CBE
80.69
39%
-73
- C1 -
2HYI
3
IF4A3_HUMAN
I:
[40-403]
---
F
D
T
M
G
L
R
E
D
L
L
R
G
I
-
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
----------
C
L
---
D
I
Q
------------------
V
---------
R
---
E
--------
T
Q
A
-
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
-
D
-
Y
-
M
----
N
---
V
Q
-
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
-
D
Y
G
--
Q
-
H
V
V
A
G
T
P
G
R
V
F
D
M
I
-
R
--
R
-
R
---
S
L
R
T
R
--
A
I
K
M
L
V
L
D
E
A
D
E
M
L
-
N
K
-
G
-
F
K
E
Q
I
Y
D
V
Y
R
Y
--
L
----
P
-------
P
A
--
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
-
R
D
----
E
L
----
T
L
E
G
I
-
K
Q
F
F
V
A
V
E
R
-
E
-
E
-
W
-
K
----
F
----
D
T
L
C
D
L
Y
D
-
T
----------
L
-
T
I
T
Q
-
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
---
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
R
------
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
---
K
-
N
D
D
-
I
R
I
-
L
R
D
I
E
Q
Y
Y
S
-
T
Q
I
D
E
M
-----------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
80.51
38%
-88
- C1 -
2VSO
1
IF4A_YEAST
B:
[24-388]
---
F
D
D
M
E
L
D
E
N
L
L
R
G
V
-
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
E
--
G
--
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
----------
R
I
---
D
T
S
------------------
V
---------
K
---
A
--------
P
Q
A
-
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
V
M
A
L
A
-
F
-
H
-
M
----
D
---
I
K
-
V
H
A
C
I
G
------------
L
R
D
--
A
-
Q
I
V
V
G
T
P
G
R
V
F
D
N
I
-
Q
--
R
-
R
---
R
F
R
T
D
--
K
I
K
M
F
I
L
D
E
A
D
E
M
L
-
S
S
-
G
-
F
K
E
Q
I
Y
Q
I
F
T
L
--
L
----
P
-------
P
T
--
T
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
V
R
I
L
V
K
-
K
D
----
E
L
----
T
L
E
G
I
-
K
Q
F
Y
V
N
V
-
E
-
E
-
E
-
E
Y
K
----
Y
----
E
C
L
T
D
L
Y
D
-
S
----------
I
-
S
V
T
Q
-
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
---
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
A
------
N
K
------
E
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
---
T
-
N
E
D
-
V
G
A
-
M
R
E
L
E
K
F
Y
S
-
T
Q
I
E
--
E
L
P
S
-------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
80.25
38%
-87
- C1 -
2VSO
1
IF4A_YEAST
A:
[24-388]
---
F
D
D
M
E
L
D
E
N
L
L
R
G
V
-
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
E
--
G
--
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
----------
R
I
---
D
T
S
------------------
V
---------
K
---
A
--------
P
Q
A
-
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
V
M
A
L
A
-
F
-
H
-
M
----
D
---
I
K
-
V
H
A
C
I
G
------------
L
R
D
--
A
-
Q
I
V
V
G
T
P
G
R
V
F
D
N
I
-
Q
--
R
-
R
---
R
F
R
T
D
--
K
I
K
M
F
I
L
D
E
A
D
E
M
L
-
S
S
-
G
-
F
K
E
Q
I
Y
Q
I
F
T
L
--
L
----
P
-------
P
T
--
T
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
V
R
I
L
V
K
-
K
D
----
E
L
----
T
L
E
G
I
-
K
Q
F
Y
V
N
V
-
E
-
E
-
E
-
E
Y
K
----
Y
----
E
C
L
T
D
L
Y
D
-
S
----------
I
-
S
V
T
Q
-
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
---
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
A
------
N
K
------
E
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
---
T
-
N
E
D
-
V
G
A
-
M
R
E
L
E
K
F
Y
S
-
T
Q
I
E
--
E
L
P
S
-------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
80.24
39%
-77
- C1 -
2HYI
3
IF4A3_HUMAN
C:
[40-403]
---
F
D
T
M
G
L
R
E
D
L
L
R
G
I
-
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
----------
C
L
---
D
I
Q
------------------
V
---------
R
---
E
--------
T
Q
A
-
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
-
D
-
Y
-
M
----
N
---
V
Q
-
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
-
D
Y
G
--
Q
-
H
V
V
A
G
T
P
G
R
V
F
D
M
I
-
R
--
R
-
R
---
S
L
R
T
R
--
A
I
K
M
L
V
L
D
E
A
D
E
M
L
-
N
K
-
G
-
F
K
E
Q
I
Y
D
V
Y
R
Y
--
L
----
P
-------
P
A
--
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
-
R
D
----
E
L
----
T
L
E
G
I
-
K
Q
F
F
V
A
V
E
R
-
E
-
E
-
W
-
K
----
F
----
D
T
L
C
D
L
Y
D
-
T
----------
L
-
T
I
T
Q
-
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
---
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
R
------
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
---
K
-
N
D
D
-
I
R
I
-
L
R
D
I
E
Q
Y
Y
S
-
T
Q
I
D
E
M
-----------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
80.07
39%
-76
- C1 -
2J0S
3
IF4A3_HUMAN
A:
[39-402]
---
F
D
T
M
G
L
R
E
D
L
L
R
G
I
-
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
----------
C
L
---
D
I
Q
------------------
V
---------
R
---
E
--------
T
Q
A
-
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
-
D
-
Y
-
M
----
N
---
V
Q
-
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
-
D
Y
G
--
Q
-
H
V
V
A
G
T
P
G
R
V
F
D
M
I
-
R
--
R
-
R
---
S
L
R
T
R
--
A
I
K
M
L
V
L
D
E
A
D
E
M
L
-
N
K
-
G
-
F
K
E
Q
I
Y
D
V
Y
R
Y
--
L
----
P
-------
P
A
--
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
-
R
D
----
E
L
----
T
L
E
G
I
-
K
Q
F
F
V
A
V
E
R
-
E
-
E
-
W
-
K
----
F
----
D
T
L
C
D
L
Y
D
-
T
----------
L
-
T
I
T
Q
-
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
---
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
R
------
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
---
K
-
N
D
D
-
I
R
I
-
L
R
D
I
E
Q
Y
Y
S
-
T
Q
I
D
E
M
-----------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
80.02
39%
-78
- C1 -
3EX7
4
IF4A3_HUMAN
C:
[40-403]
---
F
D
T
M
G
L
R
E
D
L
L
R
G
I
-
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
----------
C
L
---
D
I
Q
------------------
V
---------
R
---
E
--------
T
Q
A
-
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
-
D
-
Y
-
M
----
N
---
V
Q
-
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
-
D
Y
G
--
Q
-
H
V
V
A
G
T
P
G
R
V
F
D
M
I
-
R
--
R
-
R
---
S
L
R
T
R
--
A
I
K
M
L
V
L
D
E
A
D
E
M
L
-
N
K
-
G
-
F
K
E
Q
I
Y
D
V
Y
R
Y
--
L
----
P
-------
P
A
--
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
-
R
D
----
E
L
----
T
L
E
G
I
-
K
Q
F
F
V
A
V
E
R
-
E
-
E
-
W
-
K
----
F
----
D
T
L
C
D
L
Y
D
-
T
----------
L
-
T
I
T
Q
-
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
---
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
R
------
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
---
K
-
N
D
D
-
I
R
I
-
L
R
D
I
E
Q
Y
Y
S
-
T
Q
I
D
E
M
-----------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
79.82
38%
-86
- C1 -
2VSX
1
IF4A_YEAST
B:
[24-388]
---
F
D
D
M
E
L
D
E
N
L
L
R
G
V
-
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
E
--
G
--
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
----------
R
I
---
D
T
S
------------------
V
---------
K
---
A
--------
P
Q
A
-
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
V
M
A
L
A
-
F
-
H
-
M
----
D
---
I
K
-
V
H
A
C
I
G
------------
L
R
D
--
A
-
Q
I
V
V
G
T
P
G
R
V
F
D
N
I
-
Q
--
R
-
R
---
R
F
R
T
D
--
K
I
K
M
F
I
L
D
E
A
D
E
M
L
-
S
S
-
G
-
F
K
E
Q
I
Y
Q
I
F
T
L
--
L
----
P
-------
P
T
--
T
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
V
R
I
L
V
K
-
K
D
----
E
L
----
T
L
E
G
I
-
K
Q
F
Y
V
N
V
-
E
-
E
-
E
-
E
Y
K
----
Y
----
E
C
L
T
D
L
Y
D
-
S
----------
I
-
S
V
T
Q
-
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
---
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
A
------
N
K
------
E
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
---
T
-
N
E
D
-
V
G
A
-
M
R
E
L
E
K
F
Y
S
-
T
Q
I
E
--
E
L
P
S
-------------------------------------------------------------------------------------------------------------
122
HHSearch
79.73
35%
-126
- C1 -
1S2M
-
DHH1_YEAST
A:
[46-411]
-
N
T
F
E
D
F
Y
L
K
R
E
L
L
M
G
I
-
F
E
A
G
F
E
K
P
S
P
I
Q
E
E
A
I
P
V
A
I
T
--
G
--
R
D
I
L
A
R
A
K
N
G
T
G
K
T
A
A
F
V
I
P
T
L
E
----------
K
V
---
K
P
K
------------------
L
---------
N
---
K
--------
I
Q
A
-
L
I
M
V
P
T
R
E
L
A
L
Q
T
S
Q
V
V
R
T
L
G
-
K
-
H
-
C
----
G
---
I
S
-
C
M
V
T
T
G
G
T
N
L
R
D
D
I
L
R
L
-
N
E
T
--
V
-
H
I
L
V
G
T
P
G
R
V
L
D
L
A
-
S
--
R
-
K
---
V
A
D
L
S
--
D
C
S
L
F
I
M
D
E
A
D
K
M
L
-
S
R
-
D
-
F
K
T
I
I
E
Q
I
L
S
F
--
L
----
P
-------
P
T
--
H
Q
S
L
L
F
S
A
T
F
P
L
T
V
K
E
F
M
V
K
H
L
H
K
P
Y
E
I
N
L
M
-
E
E
-----
L
----
T
L
K
G
I
-
T
Q
Y
Y
A
F
V
-
E
-
E
-
R
-
Q
-
K
----
L
----
H
C
L
N
T
L
F
S
-
K
----------
L
-
Q
I
N
Q
-
A
I
I
F
C
N
S
T
N
R
V
E
L
L
A
K
K
I
T
D
L
---
G
Y
S
C
Y
Y
S
H
A
R
M
K
Q
Q
E
R
N
K
V
F
H
E
F
R
Q
G
K
V
R
T
L
V
C
S
D
L
L
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
K
------
T
A
------
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
---
N
-
W
N
D
-
R
F
N
-
L
Y
K
I
E
Q
E
L
G
-
T
E
I
A
A
I
P
A
---------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
79.71
39%
-75
- C1 -
2XB2
4
IF4A3_HUMAN
A:
[40-403]
---
F
D
T
M
G
L
R
E
D
L
L
R
G
I
-
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
----------
C
L
---
D
I
Q
------------------
V
---------
R
---
E
--------
T
Q
A
-
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
-
D
-
Y
-
M
----
N
---
V
Q
-
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
-
D
Y
G
--
Q
-
H
V
V
A
G
T
P
G
R
V
F
D
M
I
-
R
--
R
-
R
---
S
L
R
T
R
--
A
I
K
M
L
V
L
D
E
A
D
E
M
L
-
N
K
-
G
-
F
K
E
Q
I
Y
D
V
Y
R
Y
--
L
----
P
-------
P
A
--
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
-
R
D
----
E
L
----
T
L
E
G
I
-
K
Q
F
F
V
A
V
E
R
-
E
-
E
-
W
-
K
----
F
----
D
T
L
C
D
L
Y
D
-
T
----------
L
-
T
I
T
Q
-
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
---
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
R
------
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
---
K
-
N
D
D
-
I
R
I
-
L
R
D
I
E
Q
Y
Y
S
-
T
Q
I
D
E
M
-----------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
79.62
38%
-85
- C1 -
2VSX
1
IF4A_YEAST
A:
[24-388]
---
F
D
D
M
E
L
D
E
N
L
L
R
G
V
-
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
E
--
G
--
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
----------
R
I
---
D
T
S
------------------
V
---------
K
---
A
--------
P
Q
A
-
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
V
M
A
L
A
-
F
-
H
-
M
----
D
---
I
K
-
V
H
A
C
I
G
------------
L
R
D
--
A
-
Q
I
V
V
G
T
P
G
R
V
F
D
N
I
-
Q
--
R
-
R
---
R
F
R
T
D
--
K
I
K
M
F
I
L
D
E
A
D
E
M
L
-
S
S
-
G
-
F
K
E
Q
I
Y
Q
I
F
T
L
--
L
----
P
-------
P
T
--
T
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
V
R
I
L
V
K
-
K
D
----
E
L
----
T
L
E
G
I
-
K
Q
F
Y
V
N
V
-
E
-
E
-
E
-
E
Y
K
----
Y
----
E
C
L
T
D
L
Y
D
-
S
----------
I
-
S
V
T
Q
-
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
---
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
A
------
N
K
------
E
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
---
T
-
N
E
D
-
V
G
A
-
M
R
E
L
E
K
F
Y
S
-
T
Q
I
E
--
E
L
P
S
-------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
79.60
39%
-76
- C1 -
2XB2
5
IF4A3_HUMAN
X:
[40-403]
---
F
D
T
M
G
L
R
E
D
L
L
R
G
I
-
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
----------
C
L
---
D
I
Q
------------------
V
---------
R
---
E
--------
T
Q
A
-
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
-
D
-
Y
-
M
----
N
---
V
Q
-
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
-
D
Y
G
--
Q
-
H
V
V
A
G
T
P
G
R
V
F
D
M
I
-
R
--
R
-
R
---
S
L
R
T
R
--
A
I
K
M
L
V
L
D
E
A
D
E
M
L
-
N
K
-
G
-
F
K
E
Q
I
Y
D
V
Y
R
Y
--
L
----
P
-------
P
A
--
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
-
R
D
----
E
L
----
T
L
E
G
I
-
K
Q
F
F
V
A
V
E
R
-
E
-
E
-
W
-
K
----
F
----
D
T
L
C
D
L
Y
D
-
T
----------
L
-
T
I
T
Q
-
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
---
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
R
------
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
---
K
-
N
D
D
-
I
R
I
-
L
R
D
I
E
Q
Y
Y
S
-
T
Q
I
D
E
M
-----------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
79.37
39%
-73
- C1 -
2J0Q
3
IF4A3_HUMAN
B:
[39-402]
---
F
D
T
M
G
L
R
E
D
L
L
R
G
I
-
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
----------
C
L
---
D
I
Q
------------------
V
---------
R
---
E
--------
T
Q
A
-
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
-
D
-
Y
-
M
----
N
---
V
Q
-
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
-
D
Y
G
--
Q
-
H
V
V
A
G
T
P
G
R
V
F
D
M
I
-
R
--
R
-
R
---
S
L
R
T
R
--
A
I
K
M
L
V
L
D
E
A
D
E
M
L
-
N
K
-
G
-
F
K
E
Q
I
Y
D
V
Y
R
Y
--
L
----
P
-------
P
A
--
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
-
R
D
----
E
L
----
T
L
E
G
I
-
K
Q
F
F
V
A
V
E
R
-
E
-
E
-
W
-
K
----
F
----
D
T
L
C
D
L
Y
D
-
T
----------
L
-
T
I
T
Q
-
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
---
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
R
------
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
---
K
-
N
D
D
-
I
R
I
-
L
R
D
I
E
Q
Y
Y
S
-
T
Q
I
D
E
M
-----------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
79.23
42%
-25
- C1 -
4KBF
1
?
B:
[3-364]
---
F
K
D
F
P
L
K
P
E
I
L
E
A
L
-
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R---------
L
A
---
P
S
Q
------------------
E
RG-------
R
---
K
--------
P
R
A
-
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
-----
P
----
H
---
L
K
-
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
G
--
A
-
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
-
R
--
Q
-
G
---
V
L
D
L
S
--
R
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
M
-
G
-
F
E
E
E
V
E
A
L
L
S
A
--
T
----
P
-------
P
S
--
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
I
-
K
D
----
E
P
----
V
T
Y
E
E
-
E
A
V
P
A
P
V
-
R
-----
G
-
R
----
L
----
E
V
L
S
D
L
L
Y
-
V
----------
A
-
S
P
D
R
-
A
M
V
F
T
R
T
K
A
E
T
E
E
I
A
Q
G
L
L
R
L
---
G
H
P
A
Q
A
L
H
G
D
L
S
Q
G
E
R
E
R
V
L
G
A
F
R
Q
G
E
V
R
V
L
V
A
T
D
V
A
A
R
G
L
D
I
P
Q
V
D
L
V
V
H
Y
R
L
P
D
------
R
A
------
E
A
Y
Q
H
R
S
G
R
T
G
R
A
G
R
G
G
R
V
V
L
L
Y
---
G
-
P
R
E
-
R
R
D
-
V
E
A
L
E
R
A
V
G
-
R
R
F
K
R
V
-----------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
78.96
39%
-72
- C1 -
2J0Q
3
IF4A3_HUMAN
A:
[39-402]
---
F
D
T
M
G
L
R
E
D
L
L
R
G
I
-
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
----------
C
L
---
D
I
Q
------------------
V
---------
R
---
E
--------
T
Q
A
-
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
-
D
-
Y
-
M
----
N
---
V
Q
-
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
-
D
Y
G
--
Q
-
H
V
V
A
G
T
P
G
R
V
F
D
M
I
-
R
--
R
-
R
---
S
L
R
T
R
--
A
I
K
M
L
V
L
D
E
A
D
E
M
L
-
N
K
-
G
-
F
K
E
Q
I
Y
D
V
Y
R
Y
--
L
----
P
-------
P
A
--
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
-
R
D
----
E
L
----
T
L
E
G
I
-
K
Q
F
F
V
A
V
E
R
-
E
-
E
-
W
-
K
----
F
----
D
T
L
C
D
L
Y
D
-
T
----------
L
-
T
I
T
Q
-
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
---
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
R
------
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
---
K
-
N
D
D
-
I
R
I
-
L
R
D
I
E
Q
Y
Y
S
-
T
Q
I
D
E
M
-----------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
78.66
34%
-130
- C1 -
4BRW
2
DHH1_YEAST
A:
[3-366]
---
F
E
D
F
Y
L
K
R
E
L
L
M
G
I
-
F
E
A
G
F
E
K
P
S
P
I
Q
E
E
A
I
P
V
A
I
T
--
G
--
R
D
I
L
A
R
A
K
N
G
T
G
K
T
A
A
F
V
I
P
T
L
E
----------
K
V
---
K
P
K
------------------
L
---------
N
---
K
--------
I
Q
A
-
L
I
M
V
P
T
R
E
L
A
L
Q
T
S
Q
V
V
R
T
L
G
-
K
-
H
-
C
----
G
---
I
S
-
C
M
V
T
T
G
G
T
N
L
R
D
D
I
L
R
L
-
N
E
T
--
V
-
H
I
L
V
G
T
P
G
R
V
L
D
L
A
-
S
--
R
-
K
---
V
A
D
L
S
--
D
C
S
L
F
I
M
D
E
A
D
K
M
L
-
S
R
-
D
-
F
K
T
I
I
E
Q
I
L
S
F
--
L
----
P
-------
P
T
--
H
Q
S
L
L
F
S
A
T
F
P
L
T
V
D
E
F
M
D
K
H
L
H
K
P
Y
E
I
N
L
M
-
E
E
-----
L
----
T
L
K
G
I
-
T
Q
Y
Y
A
F
V
-
E
-
E
-
R
-
Q
-
K
----
L
----
H
C
L
N
T
L
F
S
-
K
----------
L
-
Q
I
N
Q
-
A
I
I
F
C
N
S
T
N
R
V
E
L
L
A
K
K
I
T
D
L
---
G
Y
S
C
Y
Y
S
H
A
R
M
K
Q
Q
E
R
N
K
V
F
H
E
F
R
Q
G
K
V
R
T
L
V
C
S
D
L
L
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
K
------
T
A
------
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
---
N
-
W
N
D
-
R
F
N
-
L
Y
K
I
E
Q
E
L
G
-
T
E
I
A
A
I
P
A
---------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
78.27
39%
-73
- C1 -
3EX7
4
IF4A3_HUMAN
H:
[40-403]
---
F
D
T
M
G
L
R
E
D
L
L
R
G
I
-
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
----------
C
L
---
D
I
Q
------------------
V
---------
R
---
E
--------
T
Q
A
-
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
-
D
-
Y
-
M
----
N
---
V
Q
-
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
-
D
Y
G
--
Q
-
H
V
V
A
G
T
P
G
R
V
F
D
M
I
-
R
--
R
-
R
---
S
L
R
T
R
--
A
I
K
M
L
V
L
D
E
A
D
E
M
L
-
N
K
-
G
-
F
K
E
Q
I
Y
D
V
Y
R
Y
--
L
----
P
-------
P
A
--
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
-
R
D
----
E
L
----
T
L
E
G
I
-
K
Q
F
F
V
A
V
E
R
-
E
-
E
-
W
-
K
----
F
----
D
T
L
C
D
L
Y
D
-
T
----------
L
-
T
I
T
Q
-
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
---
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
R
------
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
---
K
-
N
D
D
-
I
R
I
-
L
R
D
I
E
Q
Y
Y
S
-
T
Q
I
D
E
M
-----------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
78.04
39%
-77
- C1 -
2J0U
1
IF4A3_HUMAN
A:
[3-366]
---
F
D
T
M
G
L
R
E
D
L
L
R
G
I
-
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
V
S
V
L
Q
----------
C
L
---
D
I
Q
------------------
V
---------
R
---
E
--------
T
Q
A
-
L
I
L
A
P
T
R
E
L
A
V
Q
V
Q
K
G
L
L
A
L
G
-
D
-
Y
-
M
----
N
---
V
Q
-
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
-
D
Y
G
--
Q
-
H
V
V
A
G
T
P
G
R
V
F
D
M
I
-
R
--
R
-
R
---
S
L
R
T
R
--
A
I
K
M
L
V
L
D
E
A
D
E
M
L
-
N
K
-
G
-
F
K
E
Q
I
Y
D
V
Y
R
Y
--
L
----
P
-------
P
A
--
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
-
R
D
----
E
L
----
T
L
E
G
I
-
K
Q
F
F
V
A
V
E
R
-
E
-
E
-
W
-
K
----
F
----
D
T
L
C
D
L
Y
D
---------------
I
T
Q
-
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
---
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
--
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
R
------
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
V
N
F
V
---
K
-
N
D
D
-
I
R
V
-
L
R
D
I
E
Q
Y
Y
S
-
T
Q
I
D
E
M
-----------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
76.87
42%
-18
- C1 -
4KBG
4
?
B:
[3-364]
---
F
K
D
F
P
L
K
P
E
I
L
E
A
L
-
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R---------
L
A
---
P
S
Q
------------------
E
RG-------
R
---
K
--------
P
R
A
-
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
-----
P
----
H
---
L
K
-
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
G
--
A
-
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
-
R
--
Q
-
G
---
V
L
D
L
S
--
R
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
M
-
G
-
F
E
E
E
V
E
A
L
L
S
A
--
T
----
P
-------
P
S
--
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
I
-
K
D
----
E
P
----
V
T
Y
E
E
-
E
A
V
P
A
P
V
-
R
-----
G
-
R
----
L
----
E
V
L
S
D
L
L
Y
-
V
----------
A
-
S
P
D
R
-
A
M
V
F
T
R
T
K
A
E
T
E
E
I
A
Q
G
L
L
R
L
---
G
H
P
A
Q
A
L
H
G
D
L
S
Q
G
E
R
E
R
V
L
G
A
F
R
Q
G
E
V
R
V
L
V
A
T
D
V
A
A
R
G
L
D
I
P
Q
V
D
L
V
V
H
Y
R
L
P
D
------
R
A
------
E
A
Y
Q
H
R
S
G
R
T
G
R
A
G
R
G
G
R
V
V
L
L
Y
---
G
-
P
R
E
-
R
R
D
-
V
E
A
L
E
R
A
V
G
-
R
R
F
K
R
V
-----------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
76.55
39%
-82
- C1 -
2HXY
-
IF4A3_HUMAN
A:
[40-403]
---
F
D
T
M
G
L
R
E
D
L
L
R
G
I
-
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
----------
C
L
---
D
I
Q
------------------
V
---------
R
---
E
--------
T
Q
A
-
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
-
D
-
Y
-
M
----
N
---
V
Q
-
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
-
D
Y
G
--
Q
-
H
V
V
A
G
T
P
G
R
V
F
D
M
I
-
R
--
R
-
R
---
S
L
R
T
R
--
A
I
K
M
L
V
L
D
E
A
D
E
M
L
-
N
K
-
G
-
F
K
E
Q
I
Y
D
V
Y
R
Y
--
L
----
P
-------
P
A
--
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
-
R
D
----
E
L
----
T
L
E
G
I
-
K
Q
F
F
V
A
V
E
R
-
E
-
E
-
W
-
K
----
F
----
D
T
L
C
D
L
Y
D
-
T
----------
L
-
T
I
T
Q
-
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
---
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
R
------
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
---
K
-
N
D
D
-
I
R
I
-
L
R
D
I
E
Q
Y
Y
S
-
T
Q
I
D
E
M
-----------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
76.20
35%
-40
- C1 -
4CT4
3
DDX6_HUMAN
B:
[7-371]
---
F
E
D
Y
C
L
K
R
E
L
L
M
G
I
-
F
E
M
G
W
E
K
P
S
P
I
Q
E
E
S
I
P
I
A
L
S
--
G
--
R
D
I
L
A
R
A
K
N
G
T
G
K
S
G
A
Y
L
I
P
L
L
E
----------
R
L
---
D
L
K
------------------
K
---------
D
---
N
--------
I
Q
A
-
M
V
I
V
P
T
R
E
L
A
L
Q
V
S
Q
I
C
I
Q
V
S
-
K
H
M
-
G
----
G
---
A
K
-
V
M
A
T
T
G
G
T
N
L
R
D
D
I
M
R
L
-
D
D
T
--
V
-
H
V
V
I
A
T
P
G
R
I
L
D
L
I
-
K
--
K
-
G
---
V
A
K
V
D
--
H
V
Q
M
I
V
L
D
E
A
D
K
L
L
-
S
Q
-
D
-
F
V
Q
I
M
E
D
I
I
L
T
--
L
----
P
-------
K
N
--
R
Q
I
L
L
Y
S
A
T
F
P
L
S
V
Q
K
F
M
N
S
H
L
Q
K
P
Y
E
I
N
L
M
-
E
E
-----
L
----
T
L
K
G
V
-
T
Q
Y
Y
A
Y
V
-
T
-
E
-
R
-
Q
-
K
----
V
----
H
C
L
N
T
L
F
S
-
R
----------
L
-
Q
I
N
Q
-
S
I
I
F
C
N
S
S
Q
R
V
E
L
L
A
K
K
I
S
Q
L
---
G
Y
S
C
F
Y
I
H
A
K
M
R
Q
E
H
R
N
R
V
F
H
D
F
R
N
G
L
C
R
N
L
V
C
T
D
L
F
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
K
------
L
A
------
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
---
T
--
Y
D
-
D
R
F
N
L
K
S
I
E
E
Q
L
G
-
T
E
I
K
P
I
P
S
---------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
75.95
42%
-16
- C1 -
4KBF
3
?
A:
[3-364]
---
F
K
D
F
P
L
K
P
E
I
L
E
A
L
-
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
---------
L
A
---
P
S
Q
------------------
E
RG-------
R
---
K
--------
P
R
A
-
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
-----
P
----
H
---
L
K
-
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
G
--
A
-
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
-
R
--
Q
-
G
---
V
L
D
L
S
--
R
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
M
-
G
-
F
E
E
E
V
E
A
L
L
S
A
--
T
----
P
-------
P
S
--
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
I
-
K
D
----
E
P
----
V
T
Y
E
E
-
E
A
V
P
A
P
V
-
R
-----
G
-
R
----
L
----
E
V
L
S
D
L
L
Y
-
V
----------
A
-
S
P
D
R
-
A
M
V
F
T
R
T
K
A
E
T
E
E
I
A
Q
G
L
L
R
L
---
G
H
P
A
Q
A
L
H
G
D
L
S
Q
G
E
R
E
R
V
L
G
A
F
R
Q
G
E
V
R
V
L
V
A
T
D
V
A
A
R
G
L
D
I
P
Q
V
D
L
V
V
H
Y
R
L
P
D
------
R
A
------
E
A
Y
Q
H
R
S
G
R
T
G
R
A
G
R
G
G
R
V
V
L
L
Y
---
G
-
P
R
E
-
R
R
D
-
V
E
A
L
E
R
A
V
G
-
R
R
F
K
R
V
-----------------------------------------------------------------------------------------------------------------
131
HHSearch
74.97
42%
-15
- C1 -
4KBF
3
?
A:
[1-362]
-
M
E
F
K
D
F
P
L
K
P
E
I
L
E
A
L
-
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
----------
R
L
---
A
P
S
QER---------------
G
---------
R
---
K
--------
P
R
A
-
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
-
P
-
H
----------
L
K
-
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
G
--
A
-
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
-
R
--
Q
-
G
---
V
L
D
L
S
--
R
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
M
-
G
-
F
E
E
E
V
E
A
L
L
S
A
--
T
----
P
-------
P
S
--
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
I
-
K
D
----
E
P
----
V
T
--
Y
-
E
E
E
A
V
P
A
-
P
-
V
-
R
-
G
-
R
----
L
----
E
V
L
S
D
L
L
Y
-
V
----------
A
-
S
P
D
R
-
A
M
V
F
T
R
T
K
A
E
T
E
E
I
A
Q
G
L
L
R
L
---
G
H
P
A
Q
A
L
H
G
D
L
S
Q
G
E
R
E
R
V
L
G
A
F
R
Q
G
E
V
R
V
L
V
A
T
D
V
A
A
R
G
L
D
I
P
Q
V
D
L
V
V
H
Y
R
L
P
D
------
R
A
------
E
A
Y
Q
H
R
S
G
R
T
G
R
A
G
R
G
G
R
V
V
L
L
Y
---
G
-
P
R
E
-
R
R
D
-
V
E
A
L
E
R
A
V
G
-
R
R
F
K
-------------------------------------------------------------------------------------------------------------------
118
HHSearch
74.80
40%
-2
- C1 -
4PXA
5
DDX3X_HUMAN
A:
[65-445]
-
E
S
F
S
D
V
E
M
G
E
I
I
M
G
N
I
-
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
----------
Q
I
---
Y
S
D
GPG
E
A
L
R
A
M
K
E
NGRYGRR
K
---------
Q
---
Y
--------
P
I
S
-
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
-
Y
-
R
-
S
----
R
---
V
R
-
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
-
E
R
G
--
C
-
H
L
L
V
A
T
P
G
R
L
V
D
M
M
-
E
--
R
-
G
---
K
I
G
L
D
--
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
-
V
M
-
G
-
F
E
P
Q
I
R
R
I
V
E
Q
--
D
----
T
MPPK---
G
V
--
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
I
F
L
A
V
G
-
R
V
----
G
S
----
T
S
E
N
I
-
T
Q
K
V
V
W
V
-
E
-
E
-
S
-
D
-
K
----
R
----
S
F
L
L
D
L
L
N
-
A
----------
T
G
K
D
S
L
-
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
E
---
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
S
------
D
I
------
E
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
L
G
L
A
T
S
F
F
---
N
-
E
R
N
-
I
N
I
-
T
K
D
L
L
D
L
L
-------------------------------------------------------------------------------------------------------------------------
135
HHSearch
74.42
40%
13
- C1 -
2I4I
1
DDX3X_HUMAN
A:
[15-391]
-
E
S
F
S
D
V
E
M
G
E
I
I
M
G
N
I
-
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
----------
Q
I
---
Y
S
D
GPG
E
A
L
R
A
M
K
E
NGRYGRR
K
---------
Q
---
Y
--------
P
I
S
-
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
-
Y
-
R
-
S
----
R
---
V
R
-
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
-
E
R
G
--
C
-
H
L
L
V
A
T
P
G
R
L
V
D
M
M
-
E
--
R
-
G
---
K
I
G
L
D
--
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
-
D
M
-
G
-
F
E
P
Q
I
R
R
I
V
E
Q
--
D
TMPP
K
-------
G
V
--
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
I
F
L
A
V
G
-------------
T
S
E
N
I
-
T
Q
K
V
V
W
V
-
E
-
E
-
S
-
D
-
K
----
R
----
S
F
L
L
D
L
L
N
-
A
T---------
G
-
K
D
S
L
-
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
E
---
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
S
------
D
I
------
E
E
Y
V
H
R
I
G
R
T
G
R
--
N
L
G
L
A
T
S
F
F
---
N
-
E
R
N
-
I
N
I
-
T
K
D
L
-----------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
73.21
40%
-7
- C1 -
4PXA
5
DDX3X_HUMAN
A:
[67-429]
---
F
S
D
V
E
M
G
E
I
I
M
G
N
I
-
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
Y
S
DGPG
E
A
L
R
---
A
M
K
------------------
E
---------
N
---
G
RYGRR
K
Q
Y
P
I
S
-
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
-
Y
-
R
-
S
----
R
---
V
R
-
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
-
E
R
G
--
C
-
H
L
L
V
A
T
P
G
R
L
V
D
M
M
-
E
--
R
-
G
---
K
I
G
L
D
--
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
-
V
M
-
G
-
F
E
P
Q
I
R
R
I
V
E
Q
DT
M
----
P
-------
P
K
GV
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
I
F
L
A
V
G
-
R
V
----
G
S
----
T
S
E
N
I
-
T
Q
K
V
V
W
V
-
E
-
E
-
S
-
D
-
K
----
R
----
S
F
L
L
D
L
L
N
-
A
----------
T
-
G
K
D
S
L
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
E
---
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
S
------
D
I
------
E
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
L
G
L
A
T
S
F
-----------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
72.48
40%
13
- C1 -
2I4I
1
DDX3X_HUMAN
A:
[17-379]
---
F
S
D
V
E
M
G
E
I
I
M
G
N
I
-
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
Y
S
DGPG
E
A
L
R
---
A
M
K
------------------
E
---------
N
---
G
RYGRR
K
Q
Y
P
I
S
-
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
-
Y
-
R
-
S
----
R
---
V
R
-
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
-
E
R
G
--
C
-
H
L
L
V
A
T
P
G
R
L
V
D
M
M
-
E
--
R
-
G
---
K
I
G
L
D
--
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
-
D
M
-
G
-
F
E
P
Q
I
R
R
I
V
E
Q
DT
M
----
P
-------
P
K
GV
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
I
F
L
A
V
G
-------------
T
S
E
N
I
-
T
Q
K
V
V
W
V
-
E
-
E
-
S
-
D
-
K
----
R
----
S
F
L
L
D
L
L
N
-
A
----------
T
-
G
K
D
S
L
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
E
---
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
S
------
D
I
------
E
E
Y
V
H
R
I
G
R
T
G
R
--
N
L
G
L
A
T
S
F
-----------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
72.38
40%
8
- C1 -
5E7J
1
DDX3X_HUMAN
A:
[50-412]
---
F
S
D
V
E
M
G
E
I
I
M
G
N
I
-
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
Y
S
D
GPG
E
A
L
R
---
A
M
K
---------------------------------KQY-----
P
I
S
-
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
-
Y
-
R
-
S
----
R
---
V
R
-
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
-
E
R
G
--
C
-
H
L
L
V
A
T
P
G
R
L
V
D
M
M
-
E
--
R
-
G
---
K
I
G
L
D
--
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
-
D
M
-
G
-
F
E
P
Q
I
R
R
I
V
E
Q
DT
M
----
P
-------
P
K
GV
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
I
F
L
A
V
G
-
R
V
----
G
S
----
T
S
E
N
I
-
T
Q
K
V
V
W
V
-
E
-
E
-
S
-
D
-
K
----
R
----
S
F
L
L
D
L
L
N
-
A
----------
T
-
G
K
D
S
L
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
E
---
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
S
------
D
I
------
E
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
L
G
L
A
T
S
F
-----------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
71.87
40%
4
- C1 -
5E7M
1
DDX3X_HUMAN
A:
[50-412]
---
F
S
D
V
E
M
G
E
I
I
M
G
N
I
-
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
Y
S
D
GPG
E
A
L
R
---
A
M
K
---------------------------------R
R
K
Q
Y
---
P
I
S
-
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
-
Y
-
R
-
S
----
R
---
V
R
-
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
-
E
R
G
--
C
-
H
L
L
V
A
T
P
G
R
L
V
D
M
M
-
E
--
R
-
G
---
K
I
G
L
D
--
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
-
D
M
-
G
-
F
E
P
Q
I
R
R
I
V
E
Q
DT
M
----
P
-------
P
K
GV
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
I
F
L
A
V
G
-
R
V
----
G
S
----
T
S
E
N
I
-
T
Q
K
V
V
W
V
-
E
-
E
-
S
-
D
-
K
----
R
----
S
F
L
L
D
L
L
N
-
A
----------
T
-
G
K
D
S
L
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
E
---
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
S
------
D
I
------
E
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
L
G
L
A
T
S
F
-----------------------------------------------------------------------------------------------------------------------------------------------
119
HHSearch
70.21
34%
1
- C1 -
4D25
4
?
A:
[50-422]
-
E
S
F
E
T
A
N
L
R
K
Y
V
L
D
N
V
-
L
K
A
G
Y
R
K
P
T
P
I
Q
K
N
A
I
P
I
I
M
S
--
G
--
R
D
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
I
N
----------
M
L
---
L
Q
D
------------------
P
KD
L
I
S
E
NG
C
A
---
Q
--------
P
Q
V
-
I
I
V
S
P
T
R
E
L
T
L
Q
I
F
N
E
A
R
K
F
S
-
Y
-
G
-
S
----
V
---
L
K
-
V
A
V
A
Y
G
G
T
A
V
R
H
Q
G
D
N
I
-
A
R
G
--
C
-
H
I
L
V
A
T
P
G
R
L
H
D
F
V
-
E
--
R
-
N
---
R
V
S
F
G
--
S
V
R
F
V
V
L
D
Q
A
D
C
M
L
-
D
M
-
G
-
F
M
P
S
I
E
K
M
M
L
H
--
P
TMVE
T
-------
T
K
--
R
Q
T
L
M
F
S
A
T
F
P
E
D
I
Q
H
L
A
G
R
F
L
N
N
Y
L
F
V
A
V
G
-
I
V
----
G
G
----
A
S
T
D
V
-
E
Q
I
F
I
E
V
-
T
-
K
-
Y
-
E
-
K
----
R
----
N
S
L
K
Q
L
I
E
-
E
----------
N
-
D
G
K
R
-
I
L
V
F
V
E
T
K
R
N
A
D
F
I
A
A
M
L
S
E
Q
---
Q
L
L
T
S
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
K
------
S
I
------
D
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
F
Y
---
D
-
S
D
Q
D
L
A
L
-
V
A
D
L
S
K
I
L
R
------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
68.71
31%
-15
- C1 -
1XTI
4
DX39B_HUMAN
A:
[9-384]
--
G
F
R
D
F
L
L
K
P
E
L
L
R
A
I
-
V
D
C
G
F
E
H
P
S
E
V
Q
H
E
C
I
P
Q
A
I
L
--
G
--
M
D
V
L
C
Q
A
K
S
G
M
G
K
T
A
V
F
V
L
A
T
L
Q
----------
Q
L
---
E
P
V
------------------
T
---------
G
---
Q
--------
V
S
V
-
L
V
M
C
H
T
R
E
L
A
F
Q
I
S
K
E
Y
E
R
F
S
-
K
-
Y
M
P
----
N
---
V
K
-
V
A
V
F
F
G
G
L
S
I
K
K
D
E
E
V
L
-
K
K
N
--
C
P
H
I
V
V
G
T
P
G
R
I
L
A
L
A
-
R
--
N
-
K
---
S
L
N
L
K
--
H
I
K
H
F
I
L
D
E
C
D
K
M
L
E
Q
L
-
D
-
M
R
R
D
V
Q
E
I
F
R
M
--
T
----
P
-------
H
E
--
K
Q
V
M
M
F
S
A
T
L
S
K
E
I
R
P
V
C
R
K
F
M
Q
D
P
M
E
I
F
V
D
D
E
T
----
K
L
----
T
L
H
G
L
-
Q
Q
Y
Y
V
K
L
-
K
-
D
-
N
-
E
-
K
----
N
----
R
K
L
F
D
L
L
D
-
V
----------
L
-
E
F
N
Q
-
V
V
I
F
V
K
S
V
Q
R
C
I
A
L
A
Q
L
L
V
E
Q
---
N
F
P
A
I
A
I
H
R
G
M
P
Q
E
E
R
L
S
R
Y
Q
Q
F
K
D
F
Q
R
R
I
L
V
A
T
N
L
F
G
R
G
M
D
I
E
R
V
N
I
A
F
N
Y
D
M
P
E
------
D
S
------
D
T
Y
L
H
R
V
A
R
A
G
R
F
G
T
K
G
L
A
I
T
F
V
---
S
D
E
N
D
-
A
K
I
-
L
N
D
V
Q
D
R
---
F
E
V
N
I
S
E
L
P
D
E
I
D
I
S
--------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
66.83
31%
2
- C1 -
3RRN
3
DBP5_YEAST
A:
[7-387]
---
F
D
E
L
G
L
A
P
E
L
L
K
G
I
-
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
H
--
N
P
P
R
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
----------
R
V
---
N
P
E
------------------
D
---------
A
---
S
--------
P
Q
A
-
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
E
M
G
-
K
-
F
-
T
----
K
---
I
T
-
S
Q
L
I
V
-
P
D
S
F
E
K
N
K
----
Q
I
N
--
A
-
Q
V
I
V
G
T
P
G
T
V
L
D
L
M
-
R
--
R
-
K
---
L
M
Q
L
Q
--
K
I
K
I
F
V
L
D
E
A
D
N
M
L
-
D
Q
Q
G
-
L
G
D
Q
C
I
R
V
K
R
F
--
L
----
P
-------
K
D
--
T
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
N
A
N
T
L
E
L
Q
---------------
D
A
I
-
K
Q
L
Y
M
D
C
-
K
-
N
-
E
A
D
-
K
----
F
----
D
V
L
T
E
L
Y
G
-
V
----------
M
-
T
I
G
S
-
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
E
---
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
T
LANGQA
D
P
------
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
HD
K
N
-
S
F
N
---
I
-
L
S
A
I
Q
K
Y
F
G
D
I
E
M
T
R
V
P
T
D
D
W
D
E
V
E
K
-------------------------------------------------------------------------------------------------------
130
HHSearch
66.82
30%
18
- C1 -
4LJY
4
PRP5_YEAST
A:
[50-437]
-
T
K
W
S
Q
L
G
L
S
T
D
T
M
V
L
I
T
E
K
L
H
F
G
S
L
T
P
I
Q
S
Q
A
L
P
A
I
M
S
--
G
--
R
D
V
I
G
I
S
K
T
G
S
G
K
T
I
S
Y
L
L
P
L
L
R
----------
Q
V
---
K
A
Q
------------------
R
PLSKHE---
T
---
G
--------
P
M
G
-
L
I
L
A
P
T
R
E
L
A
L
Q
I
H
E
E
V
T
K
F
T
-
E
-
A
D
T
----
S
---
I
R
-
S
V
C
C
T
G
G
S
E
M
K
K
Q
I
T
D
L
-
K
R
G
--
T
-
E
I
V
V
A
T
P
G
R
F
I
D
I
L
-
T
--
L
-
N
DGK
L
L
S
T
K
--
R
I
T
F
V
V
M
D
E
A
D
R
L
F
-
D
L
-
G
-
F
E
P
Q
I
T
Q
I
M
K
T
--
V
----
R
-------
P
D
--
K
Q
C
V
L
F
S
A
T
F
P
N
K
L
R
S
F
A
V
R
V
L
H
S
P
I
S
I
T
I
N
-
S
K
----
G
M
----
V
N
E
N
V
-
K
Q
K
F
R
I
C
-
H
-
S
E
D
-
E
-
K
----
F
----
D
N
L
V
Q
L
I
H
-
E
R
S
E
F
F
D
E
V
Q
S---
D
A
K
-
A
I
I
F
V
S
S
Q
N
I
C
D
F
I
S
K
K
L
L
N
A
---
G
I
V
T
C
A
I
H
A
G
K
P
Y
Q
E
R
L
M
N
L
E
K
F
K
R
E
K
N
S
I
L
L
C
T
E
V
L
S
R
G
L
N
V
P
E
V
S
L
V
I
I
Y
N
A
V
K
------
T
F
------
A
Q
Y
V
H
T
T
G
R
T
A
R
G
S
R
S
G
T
A
I
T
L
L
---
L
-
H
D
E
-
L
S
G
-
A
Y
I
L
S
K
---------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
65.18
31%
3
- C1 -
3PEW
10
DBP5_YEAST
A:
[7-387]
---
F
D
E
L
G
L
A
P
E
L
L
K
G
I
-
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
H
--
N
P
P
R
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
----------
R
V
---
N
P
E
------------------
D
---------
A
---
S
--------
P
Q
A
-
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
E
M
G
-
K
-
F
-
T
----
K
---
I
T
-
S
Q
L
I
V
-
P
D
S
F
E
K
N
K
----
Q
I
N
--
A
-
Q
V
I
V
G
T
P
G
T
V
L
D
L
M
-
R
--
R
-
K
---
L
M
Q
L
Q
--
K
I
K
I
F
V
L
D
E
A
D
N
M
L
-
D
Q
Q
G
-
L
G
D
Q
C
I
R
V
K
R
F
--
L
----
P
-------
K
D
--
T
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
N
A
N
T
L
E
L
Q
-
T
N
----
E
V
----
N
V
D
A
I
-
K
Q
L
Y
M
D
C
-
K
-
N
-
E
A
D
-
K
----
F
----
D
V
L
T
E
L
Y
G
-
V
----------
M
-
T
I
G
S
-
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
E
---
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
T
LANGQA
D
P
------
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
H
D
K
N
-
S
F
N
---
I
-
L
S
A
I
Q
K
Y
F
G
D
I
E
M
T
R
V
P
T
D
D
W
D
E
V
E
K
-------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
65.15
32%
17
- C1 -
3FHT
6
DD19B_HUMAN
B:
[27-400]
---
F
E
E
L
R
L
K
P
Q
L
L
Q
G
V
-
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
A
--
E
P
P
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
----------
Q
V
---
E
P
A
------------------
N
---------
K
---
Y
--------
P
Q
C
-
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
-
K
-
F
Y
P
----
E
---
L
K
L
A
Y
A
V
R
G
N
-------------
K
IS
E
-
Q
I
V
I
G
T
P
G
T
V
L
D
W
C
-
S
--
K
L
K
---
F
I
D
P
K
--
K
I
K
V
F
V
L
D
E
A
D
V
M
I
A
T
Q
-
G
-
H
Q
D
Q
S
I
R
I
Q
R
M
--
L
----
P
-------
R
N
--
C
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
V
I
K
L
K
-
R
E
----
E
E
----
T
L
D
T
I
K
Q
Y
Y
V
L
C
S
-
S
-
R
-
D
-
E
-
K
----
F
----
Q
A
L
C
N
L
Y
G
-
A
----------
I
-
T
I
A
Q
-
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
K
E
---
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
V
------
D
K
DGNPD
N
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
D--
S
-
K
H
S
-
M
N
I
-
L
N
R
I
Q
E
H
F
N
-
K
K
I
E
R
L
D
----------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
64.80
35%
11
- C1 -
4D25
4
?
A:
[69-404]
---------------------
G
Y
R
K
P
T
P
I
Q
K
N
A
I
P
I
I
M
S
--
G
--
R
D
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
I
N
----------
M
L
---
L
Q
D
PKD
L
I
S
------------
E
---------
N
G
C
A
Q
--------
P
Q
V
-
I
I
V
S
P
T
R
E
L
T
L
Q
I
F
N
E
A
R
K
F
S
-
Y
-
G
-
S
----
V
---
L
K
-
V
A
V
A
Y
G
G
T
A
V
R
H
Q
G
D
N
I
-
A
R
G
--
C
-
H
I
L
V
A
T
P
G
R
L
H
D
F
V
-
E
--
R
-
N
---
R
V
S
F
G
--
S
V
R
F
V
V
L
D
Q
A
D
C
M
L
-
D
M
-
G
-
F
M
P
S
I
E
K
M
M
L
H
--
P
----
T
MVET---
T
K
--
R
Q
T
L
M
F
S
A
T
F
P
E
D
I
Q
H
L
A
G
R
F
L
N
N
Y
L
F
V
A
V
G
-
I
V
----
G
G
----
A
S
T
D
V
-
E
Q
I
F
I
E
V
-
T
-
K
-
Y
-
E
-
K
----
R
----
N
S
L
K
Q
L
I
E
-
E
----------
N
-
D
G
K
R
-
I
L
V
F
V
E
T
K
R
N
A
D
F
I
A
A
M
L
S
E
Q
---
Q
L
L
T
S
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
K
------
S
I
------
D
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
F
-----------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
64.78
31%
3
- C1 -
3PEY
11
DBP5_YEAST
A:
[7-387]
---
F
D
E
L
G
L
A
P
E
L
L
K
G
I
-
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
H
--
N
P
P
R
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
----------
R
V
---
N
P
E
------------------
D
---------
A
---
S
--------
P
Q
A
-
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
E
M
G
-
K
-
F
-
T
----
K
---
I
T
-
S
Q
L
I
V
-
P
D
S
F
E
K
N
K
----
Q
I
N
--
A
-
Q
V
I
V
G
T
P
G
T
V
L
D
L
M
-
R
--
R
-
K
---
L
M
Q
L
Q
--
K
I
K
I
F
V
L
D
E
A
D
N
M
L
-
D
Q
Q
G
-
L
G
D
Q
C
I
R
V
K
R
F
--
L
----
P
-------
K
D
--
T
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
N
A
N
T
L
E
L
Q
-
T
N
----
E
V
----
N
V
D
A
I
-
K
Q
L
Y
M
D
C
-
K
-
N
-
E
A
D
-
K
----
F
----
D
V
L
T
E
L
Y
G
-
L
----------
M
-
T
I
G
S
-
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
E
---
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
T
LANGQA
D
P
------
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
H
D
K
N
-
S
F
N
---
I
-
L
S
A
I
Q
K
Y
F
G
D
I
E
M
T
R
V
P
T
D
D
W
D
E
V
E
K
-------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
64.40
31%
4
- C1 -
5ELX
7
?
A:
[4-384]
---
F
D
E
L
G
L
A
P
E
L
L
K
G
I
-
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
H
--
N
P
P
R
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
----------
R
V
---
N
P
E
------------------
D
---------
A
---
S
--------
P
Q
A
-
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
E
M
G
-
K
-
F
-
T
----
K
---
I
T
-
S
Q
L
I
V
-
P
D
S
F
E
K
N
K
----
Q
I
N
--
A
-
Q
V
I
V
G
T
P
G
T
V
L
D
L
M
-
R
--
R
-
K
---
L
M
Q
L
Q
--
K
I
K
I
F
V
L
D
E
A
D
N
M
L
-
D
Q
Q
G
-
L
G
D
Q
C
I
R
V
K
R
F
--
L
----
P
-------
K
D
--
T
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
N
A
N
T
L
E
L
Q
-
T
N
----
E
V
----
N
V
D
A
I
-
K
Q
L
Y
M
D
C
-
K
-
N
-
E
A
D
-
K
----
F
----
D
V
L
T
E
L
Y
G
-
L
----------
M
-
T
I
G
S
-
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
E
---
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
T
LANGQA
D
P
------
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
H
D
K
N
-
S
F
N
---
I
-
L
S
A
I
Q
K
Y
F
G
D
I
E
M
T
R
V
P
T
D
D
W
D
E
V
E
K
-------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
63.91
35%
7
- C1 -
4D26
4
?
A:
[69-404]
---------------------
G
Y
R
K
P
T
P
I
Q
K
N
A
I
P
I
I
M
S
--
G
--
R
D
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
I
N
----------
M
L
---
L
Q
D
P
K
D
L
I
S
------------
E
---------
N
G
C
A
Q
--------
P
Q
V
-
I
I
V
S
P
T
R
E
L
T
L
Q
I
F
N
E
A
R
K
F
S
-
Y
-
G
-
S
----
V
---
L
K
-
V
A
V
A
Y
G
G
T
A
V
R
H
Q
G
D
N
I
-
A
R
G
--
C
-
H
I
L
V
A
T
P
G
R
L
H
D
F
V
-
E
--
R
-
N
---
R
V
S
F
G
--
S
V
R
F
V
V
L
D
Q
A
D
C
M
L
-
D
M
-
G
-
F
M
P
S
I
E
K
M
M
L
H
--
P
----
T
MVET---
T
K
--
R
Q
T
L
M
F
S
A
T
F
P
E
D
I
Q
H
L
A
G
R
F
L
N
N
Y
L
F
V
A
V
G
-
I
V
----
G
G
----
A
S
T
D
V
-
E
Q
I
F
I
E
V
-
T
-
K
-
Y
-
E
-
K
----
R
----
N
S
L
K
Q
L
I
E
-
E
----------
N
-
D
G
K
R
-
I
L
V
F
V
E
T
K
R
N
A
D
F
I
A
A
M
L
S
E
Q
---
Q
L
L
T
S
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
K
------
S
I
------
D
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
F
-----------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
63.78
32%
26
- C1 -
3EWS
1
DD19B_HUMAN
A:
[64-442]
---
F
E
E
L
R
L
K
P
Q
L
L
Q
G
V
-
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
A
--
E
P
P
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
----------
Q
V
---
E
P
A
------------------
N
---------
K
---
Y
--------
P
Q
C
-
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
-
K
-
F
Y
P
----
E
---
L
K
L
A
Y
A
V
R
G
N
------
K
L
E
R
-
G
Q
K
IS
E
-
Q
I
V
I
G
T
P
G
T
V
L
D
W
C
-
S
--
K
L
K
---
F
I
D
P
K
--
K
I
K
V
F
V
L
D
E
A
D
V
M
I
A
T
Q
-
G
-
H
Q
D
Q
S
I
R
I
Q
R
M
--
L
----
P
-------
R
N
--
C
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
V
I
K
L
K
-
R
E
----
E
E
----
T
L
D
T
I
K
Q
Y
Y
V
L
C
S
-
S
-
R
-
D
-
E
-
K
----
F
----
Q
A
L
C
N
L
Y
G
-
A
----------
I
-
T
I
A
Q
-
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
K
E
---
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
V
------
D
K
DGNPD
N
E
T
Y
L
H
R
I
G
R
----
G
K
R
G
L
A
V
N
M
V
D
--
S
-
K
H
S
-
M
N
I
-
L
N
R
I
Q
E
H
F
N
-
K
K
I
E
R
L
D
T
D
D
L
D
-----------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
62.92
32%
15
- C1 -
3FHT
4
DD19B_HUMAN
A:
[27-399]
---
F
E
E
L
R
L
K
P
Q
L
L
Q
G
V
-
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
A
--
E
P
P
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
----------
Q
V
---
E
P
A
------------------
N
---------
K
---
Y
--------
P
Q
C
-
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
-
K
-
F
Y
P
----
E
---
L
K
L
A
Y
A
V
R
G
N
------
K
L
E
R
-
G
Q
K
IS
E
-
Q
I
V
I
G
T
P
G
T
V
L
D
W
C
-
S
--
K
L
K
---
F
I
D
P
K
--
K
I
K
V
F
V
L
D
E
A
D
V
M
I
A
T
Q
-
G
-
H
Q
D
Q
S
I
R
I
Q
R
M
--
L
----
P
-------
R
N
--
C
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
V
I
K
L
K
-
R
E
----
E
E
----
T
L
D
T
I
K
Q
Y
Y
V
L
C
S
-
S
-
R
-
D
-
E
-
K
----
F
----
Q
A
L
C
N
L
Y
G
-
A
----------
I
-
T
I
A
Q
-
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
K
E
---
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
V
------
D
K
DGNPD
N
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
D--
S
-
K
H
S
-
M
N
I
-
L
N
R
I
Q
E
H
F
N
-
K
K
I
E
R
L
-----------------------------------------------------------------------------------------------------------------
133
HHSearch
62.58
32%
0
- C1 -
3PEY
11
DBP5_YEAST
A:
[5-357]
-
K
S
F
D
E
L
G
L
A
P
E
L
L
K
G
I
-
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
H
--
N
P
P
R
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
----------
R
V
---
N
P
E
------------------
D
---------
A
---
S
--------
P
Q
A
-
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
E
M
G
-
K
-
F
-
T
----
K
---
I
T
-
S
Q
L
I
V
P
D
S
F
----
E
K
N
K
-
Q
I
N
--
A
-
Q
V
I
V
G
T
P
G
T
V
L
D
L
M
-
R
--
R
-
K
---
L
M
Q
L
Q
--
K
I
K
I
F
V
L
D
E
A
D
N
M
L
-
D
Q
Q
G
-
L
G
D
Q
C
I
R
V
K
R
F
--
L
----
P
-------
K
D
--
T
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
N
A
N
T
L
E
L
Q
-
T
N
----
E
V
----
N
V
D
A
I
-
K
Q
L
Y
M
D
C
-
K
-
N
E
A
-
D
-
K
----
F
----
D
V
L
T
E
L
Y
G
-
L
----------
M
-
T
I
G
S
-
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
E
---
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
T
LANGQA
D
P
------
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
---
H
-
D
K
N
--------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
62.10
32%
17
- C1 -
3G0H
4
DD19B_HUMAN
A:
[43-416]
---
F
E
E
L
R
L
K
P
Q
L
L
Q
G
V
-
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
A
--
E
P
P
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
----------
Q
V
---
E
P
A
------------------
N
---------
K
---
Y
--------
P
Q
C
-
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
-
K
-
F
Y
P
----
E
---
L
K
L
A
Y
A
V
R
G
N
------
K
L
E
R
-
G
Q
K
IS
E
-
Q
I
V
I
G
T
P
G
T
V
L
D
W
C
-
S
--
K
L
K
---
F
I
D
P
K
--
K
I
K
V
F
V
L
D
E
A
D
V
M
I
A
T
Q
-
G
-
H
Q
D
Q
S
I
R
I
Q
R
M
--
L
----
P
-------
R
N
--
C
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
V
I
K
L
K
-
R
E
----
E
E
----
T
L
D
T
I
K
Q
Y
Y
V
L
C
S
-
S
-
R
-
D
-
E
-
K
----
F
----
Q
A
L
C
N
L
Y
G
-
A
----------
I
-
T
I
A
Q
-
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
K
E
---
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
V
------
D
K
DGNPD
N
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
D--
S
-
K
H
S
-
M
N
I
-
L
N
R
I
Q
E
H
F
N
-
K
K
I
E
R
L
D
----------------------------------------------------------------------------------------------------------------
134
HHSearch
61.87
30%
14
- C1 -
3SQW
3
MS116_YEAST
A:
[27-408]
-------
V
L
D
K
E
I
H
K
A
I
-
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
S
SE
D
--
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
----------
H
L
---
I
N
T
KFDS--------------
Q
---------
Y
---
M
--------
V
K
A
-
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
K
I
H
-
D
-
M
-
N
YGLK
K
---
Y
A
-
C
V
S
L
V
G
G
T
D
F
R
A
A
M
N
K
M
N
K
L
R
--
P
-
N
I
V
I
A
T
P
G
R
L
I
D
V
L
-
E
--
K
-
Y
S--
N
K
F
F
R
--
F
V
D
Y
K
V
L
D
E
A
D
R
L
L
-
E
I
-
G
-
F
R
D
D
L
E
T
I
S
G
I
--
L
----
N
E
K
NSKSA
D
N
--
I
K
T
L
L
F
S
A
T
L
D
D
K
V
Q
K
L
A
N
N
I
M
N
K
K
E
C
L
F
L
D
-
T
V
----
D
K
NEPE
A
H
E
R
I
-
D
Q
S
V
V
I
S
-
E
K
F
-
A
-
N
-
S
I
F
A
A
V
----
E
H
I
K
K
Q
I
K
E
R
----------
D
-
S
N
Y
K
-
A
I
I
F
A
P
T
V
K
F
T
S
F
L
C
S
I
L
K
N
E
FKK
D
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
S
------
E
L
------
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
---
C
-
K
D
E
-
L
P
F
-
V
R
E
L
E
D
---------------------------------------------------------------------------------------------------------------------------
127
HHSearch
60.75
32%
28
- C1 -
3FHT
4
DD19B_HUMAN
A:
[25-399]
-
K
S
F
E
E
L
R
L
K
P
Q
L
L
Q
G
V
-
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
A
--
E
P
P
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
----------
Q
V
---
E
P
A
------------------
N
---------
K
---
Y
--------
P
Q
C
-
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
-
K
-
F
-
Y
----
P
E--
L
K
-
L
A
Y
A
V
R
G
N
---
K
L
E
R
G
Q
-
K
I
S
--
E
-
Q
I
V
I
G
T
P
G
T
V
L
D
W
C
-
S
--
K
-
L
K--
F
I
D
P
K
--
K
I
K
V
F
V
L
D
E
A
D
V
M
I
-
A
T
Q
G
-
H
Q
D
Q
S
I
R
I
Q
R
M
--
L
----
P
-------
R
N
--
C
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
V
I
K
L
K
-
R
E
----
E
E
----
T
L
D
T
I
-
K
Q
Y
Y
V
L
C
-
S
-
S
R
D
-
E
-
K
----
F
----
Q
A
L
C
N
L
Y
G
-
A
----------
I
-
T
I
A
Q
-
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
K
E
---
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
V
DKDGNP
D
N
------
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
---
D
-
S
K
H
S
M
N
I
-
L
N
R
I
Q
E
H
F
N
-
K
K
I
E
R
L
-----------------------------------------------------------------------------------------------------------------
128
HHSearch
60.64
30%
14
- C1 -
3I5X
3
MS116_YEAST
A:
[78-458]
-------
V
L
D
K
E
I
H
K
A
I
-
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
S
SE
D
--
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
----------
H
L
---
I
N
T
KFDS--------------
Q
---------
Y
---
M
--------
V
K
A
-
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
K
I
H
-
D
-
M
-
N
Y---
G
LKK
Y
A
-
C
V
S
L
V
G
G
T
D
F
R
A
A
M
N
K
M
N
K
L
R
--
P
-
N
I
V
I
A
T
P
G
R
L
I
D
V
L
-
E
--
K
-
Y
S--
N
K
F
F
R
--
F
V
D
Y
K
V
L
D
E
A
D
R
L
L
-
E
I
-
G
-
F
R
D
D
L
E
T
I
S
G
I
--
L
----
N
E
K
NSKSA
D
N
--
I
K
T
L
L
F
S
A
T
L
D
D
K
V
Q
K
L
A
N
N
I
M
N
K
K
E
C
L
F
L
D
-
T
V
DKNE
P
E
----
A
H
E
R
I
-
D
Q
S
V
V
I
S
-
E
-
K
F
A
-
N
-
S
----
I
F
A
A
V
E
H
I
K
K
Q
I
K
E
R
----------
D
-
S
N
Y
K
-
A
I
I
F
A
P
T
V
K
F
T
S
F
L
C
S
I
L
K
N
E
FKK
D
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
S
------
E
L
------
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
---
C
-
K
D
E
-
L
P
F
-
V
R
E
L
E
----------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
58.43
47%
-41
- C1 -
2GXQ
2
?
A:
[2-205]
--
E
F
K
D
F
P
L
K
P
E
I
L
E
A
L
-
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
---------
L
A
---
P
S
Q
------------------
E
---------
R
GR-
K
--------
P
R
A
-
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
-----
P
----
H
---
L
K
-
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
G
--
A
-
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
-
R
--
Q
-
G
---
V
L
D
L
S
--
R
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
M
-
G
-
F
E
E
E
V
E
A
L
L
S
A
--
T
----
P
-------
P
S
--
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
58.27
32%
-66
- C1 -
1T6N
1
DX39B_HUMAN
A:
[14-220]
-
S
G
F
R
D
F
L
L
K
P
E
L
L
R
A
I
-
V
D
C
G
F
E
H
P
S
E
V
Q
H
E
C
I
P
Q
A
I
L
--
G
--
M
D
V
L
C
Q
A
K
S
G
M
G
K
T
A
V
F
V
L
A
T
L
Q
----------
Q
L
---
E
P
V
------------------
T
---------
G
---
Q
--------
V
S
V
-
L
V
M
C
H
T
R
E
L
A
F
Q
I
S
K
E
Y
E
R
F
S
-
K
-
Y
M
P
----
N
---
V
K
-
V
A
V
F
F
G
G
L
S
I
K
K
D
E
E
V
L
-
K
K
N
--
C
P
H
I
V
V
G
T
P
G
R
I
L
A
L
A
-
R
--
N
-
K
---
S
L
N
L
K
--
H
I
K
H
F
I
L
D
E
C
D
K
M
L
E
Q
L
-
D
-
M
R
R
D
V
Q
E
I
F
R
M
--
T
----
P
-------
H
E
--
K
Q
V
M
M
F
S
A
T
L
S
K
E
I
R
P
V
C
R
K
F
M
Q
D
P
M
E
I
F
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
57.51
47%
-32
- C1 -
2GXS
4
?
B:
[2-205]
--
E
F
K
D
F
P
L
K
P
E
I
L
E
A
L
-
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R---------
L
A
---
P
S
Q
------------------
E
---------
R
GR-
K
--------
P
R
A
-
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
-----
P
----
H
---
L
K
-
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
G
--
A
-
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
-
R
--
Q
-
G
---
V
L
D
L
S
--
R
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
M
-
G
-
F
E
E
E
V
E
A
L
L
S
A
--
T
----
P
-------
P
S
--
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
57.26
32%
-63
- C1 -
2OXC
1
DDX20_HUMAN
B:
[24-228]
-
A
D
F
E
S
L
L
L
S
R
P
V
L
E
G
L
-
R
A
A
G
F
E
R
P
S
P
V
Q
L
K
A
I
P
L
G
R
C
--
G
--
L
D
L
I
V
Q
A
K
S
G
T
G
K
T
C
V
F
S
T
I
A
L
D
----------
S
L
---
V
L
E
------------------
N
---------
L
---
S
--------
T
Q
I
-
L
I
L
A
P
T
R
E
I
A
V
Q
I
H
S
V
I
T
A
I
G
I
K
-
M
-
E
----
G
---
L
E
-
C
H
V
F
I
G
G
T
P
L
S
Q
D
K
T
R
L
-
K
-
K
--
C
-
H
I
A
V
G
S
P
G
R
I
K
Q
L
I
-
E
--
L
-
D
---
Y
L
N
P
G
--
S
I
R
L
F
I
L
D
E
A
D
K
L
L
-
E
E
-
G
S
F
Q
E
Q
I
N
W
I
Y
S
S
--
L
----
P
-------
A
S
--
K
Q
M
L
A
V
S
A
T
Y
P
E
F
L
A
N
A
L
T
K
Y
M
R
D
P
T
F
V
R
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
57.26
39%
-64
- C1 -
3BER
4
DDX47_HUMAN
A:
[45-249]
---
F
K
D
L
G
V
T
D
V
L
C
E
A
C
-
D
Q
L
G
W
T
K
P
T
K
I
Q
I
E
A
I
P
L
A
L
Q
--
G
--
R
D
I
I
G
L
A
E
T
G
S
G
K
T
G
A
F
A
L
P
I
L
N
----------
A
L
---
L
E
T
------------------
P
---------
Q
---
R
--------
L
F
A
-
L
V
L
T
P
T
R
E
L
A
F
Q
I
S
E
Q
F
E
A
L
G
-
S
-
S
-
I
----
G
---
V
Q
-
S
A
V
I
V
G
G
I
D
S
M
S
Q
S
L
A
L
-
A
K
K
--
P
-
H
I
I
I
A
T
P
G
R
L
I
D
H
L
-
E
NT
K
-
G
----
F
N
L
R
--
A
L
K
Y
L
V
M
D
E
A
D
R
I
L
-
N
M
-
D
-
F
E
T
E
V
D
K
I
L
K
V
--
I
----
P
-------
R
D
--
R
K
T
F
L
F
S
A
T
M
T
K
K
V
Q
K
L
Q
R
A
A
L
K
N
P
V
K
C
A
V
S
-
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
56.91
47%
-34
- C1 -
2GXS
3
?
A:
[2-205]
--
E
F
K
D
F
P
L
K
P
E
I
L
E
A
L
-
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
---------
L
A
---
P
S
Q
------------------
E
---------
R
GR-
K
--------
P
R
A
-
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
-----
P
----
H
---
L
K
-
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
G
--
A
-
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
-
R
--
Q
-
G
---
V
L
D
L
S
--
R
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
M
-
G
-
F
E
E
E
V
E
A
L
L
S
A
--
T
----
P
-------
P
S
--
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
56.86
32%
-63
- C1 -
1T6N
1
DX39B_HUMAN
B:
[14-220]
-
S
G
F
R
D
F
L
L
K
P
E
L
L
R
A
I
-
V
D
C
G
F
E
H
P
S
E
V
Q
H
E
C
I
P
Q
A
I
L
--
G
--
M
D
V
L
C
Q
A
K
S
G
M
G
K
T
A
V
F
V
L
A
T
L
Q
----------
Q
L
---
E
P
V
------------------
T
---------
G
---
Q
--------
V
S
V
-
L
V
M
C
H
T
R
E
L
A
F
Q
I
S
K
E
Y
E
R
F
S
-
K
-
Y
M
P
----
N
---
V
K
-
V
A
V
F
F
G
G
L
S
I
K
K
D
E
E
V
L
-
K
K
N
--
C
P
H
I
V
V
G
T
P
G
R
I
L
A
L
A
-
R
--
N
-
K
---
S
L
N
L
K
--
H
I
K
H
F
I
L
D
E
C
D
K
M
L
E
Q
L
-
D
-
M
R
R
D
V
Q
E
I
F
R
M
--
T
----
P
-------
H
E
--
K
Q
V
M
M
F
S
A
T
L
S
K
E
I
R
P
V
C
R
K
F
M
Q
D
P
M
E
I
F
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
56.83
46%
-30
- C1 -
3NBF
2
?
A:
[2-205]
--
E
F
K
D
F
P
L
K
P
E
I
L
E
A
L
-
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
---------
L
A
---
P
S
Q
------------------
E
---------
R
GR-
K
--------
P
R
A
-
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
-----
P
----
H
---
L
K
-
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
G
--
A
-
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
-
R
--
Q
-
G
---
V
L
D
L
S
--
R
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
M
-
G
-
F
E
E
E
V
E
A
L
L
S
A
--
T
----
P
-------
P
S
--
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
56.45
46%
-42
- C1 -
3MWK
2
?
B:
[2-205]
--
E
F
K
D
F
P
L
K
P
E
I
L
E
A
L
-
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R---------
L
A
---
P
S
Q
------------------
E
---------
R
GR-
K
--------
P
R
A
-
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
-----
P
----
H
---
L
K
-
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
G
--
A
-
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
-
R
--
Q
-
G
---
V
L
D
L
S
--
R
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
M
-
G
-
F
E
E
E
V
E
A
L
L
S
A
--
T
----
P
-------
P
S
--
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
56.31
32%
-61
- C1 -
3B7G
1
DDX20_HUMAN
B:
[24-228]
-
A
D
F
E
S
L
L
L
S
R
P
V
L
E
G
L
-
R
A
A
G
F
E
R
P
S
P
V
Q
L
K
A
I
P
L
G
R
C
--
G
--
L
D
L
I
V
Q
A
K
S
G
T
G
K
T
C
V
F
S
T
I
A
L
D
----------
S
L
---
V
L
E
------------------
N
---------
L
---
S
--------
T
Q
I
-
L
I
L
A
P
T
R
E
I
A
V
Q
I
H
S
V
I
T
A
I
G
I
K
-
M
-
E
----
G
---
L
E
-
C
H
V
F
I
G
G
T
P
L
S
Q
D
K
T
R
L
-
K
-
K
--
C
-
H
I
A
V
G
S
P
G
R
I
K
Q
L
I
-
E
--
L
-
D
---
Y
L
N
P
G
--
S
I
R
L
F
I
L
D
E
A
D
K
L
L
-
E
E
-
G
S
F
Q
E
Q
I
N
W
I
Y
S
S
--
L
----
P
-------
A
S
--
K
Q
M
L
A
V
S
A
T
Y
P
E
F
L
A
N
A
L
T
K
Y
M
R
D
P
T
F
V
R
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
56.25
32%
-60
- C1 -
2OXC
1
DDX20_HUMAN
A:
[24-228]
-
A
D
F
E
S
L
L
L
S
R
P
V
L
E
G
L
-
R
A
A
G
F
E
R
P
S
P
V
Q
L
K
A
I
P
L
G
R
C
--
G
--
L
D
L
I
V
Q
A
K
S
G
T
G
K
T
C
V
F
S
T
I
A
L
D
----------
S
L
---
V
L
E
------------------
N
---------
L
---
S
--------
T
Q
I
-
L
I
L
A
P
T
R
E
I
A
V
Q
I
H
S
V
I
T
A
I
G
I
K
-
M
-
E
----
G
---
L
E
-
C
H
V
F
I
G
G
T
P
L
S
Q
D
K
T
R
L
-
K
-
K
--
C
-
H
I
A
V
G
S
P
G
R
I
K
Q
L
I
-
E
--
L
-
D
---
Y
L
N
P
G
--
S
I
R
L
F
I
L
D
E
A
D
K
L
L
-
E
E
-
G
S
F
Q
E
Q
I
N
W
I
Y
S
S
--
L
----
P
-------
A
S
--
K
Q
M
L
A
V
S
A
T
Y
P
E
F
L
A
N
A
L
T
K
Y
M
R
D
P
T
F
V
R
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
56.24
32%
-59
- C1 -
3B7G
1
DDX20_HUMAN
A:
[24-228]
-
A
D
F
E
S
L
L
L
S
R
P
V
L
E
G
L
-
R
A
A
G
F
E
R
P
S
P
V
Q
L
K
A
I
P
L
G
R
C
--
G
--
L
D
L
I
V
Q
A
K
S
G
T
G
K
T
C
V
F
S
T
I
A
L
D
----------
S
L
---
V
L
E
------------------
N
---------
L
---
S
--------
T
Q
I
-
L
I
L
A
P
T
R
E
I
A
V
Q
I
H
S
V
I
T
A
I
G
I
K
-
M
-
E
----
G
---
L
E
-
C
H
V
F
I
G
G
T
P
L
S
Q
D
K
T
R
L
-
K
-
K
--
C
-
H
I
A
V
G
S
P
G
R
I
K
Q
L
I
-
E
--
L
-
D
---
Y
L
N
P
G
--
S
I
R
L
F
I
L
D
E
A
D
K
L
L
-
E
E
-
G
S
F
Q
E
Q
I
N
W
I
Y
S
S
--
L
----
P
-------
A
S
--
K
Q
M
L
A
V
S
A
T
Y
P
E
F
L
A
N
A
L
T
K
Y
M
R
D
P
T
F
V
R
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
56.11
46%
-35
- C1 -
3NBF
4
?
C:
[2-205]
--
E
F
K
D
F
P
L
K
P
E
I
L
E
A
L
-
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R---------
L
A
---
P
S
Q
------------------
E
---------
R
G
R
-
K
--------
P
R
A
-
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
-----
P
----
H
---
L
K
-
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
G
--
A
-
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
-
R
--
Q
-
G
---
V
L
D
L
S
--
R
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
M
-
G
-
F
E
E
E
V
E
A
L
L
S
A
--
T
----
P
-------
P
S
--
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
54.91
46%
-39
- C1 -
3MWL
2
?
B:
[2-205]
--
E
F
K
D
F
P
L
K
P
E
I
L
E
A
L
-
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R---------
L
A
---
P
S
Q
------------------
E
---------
R
GR-
K
--------
P
R
A
-
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
-----
P
----
H
---
L
K
-
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
G
--
A
-
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
-
R
--
Q
-
G
---
V
L
D
L
S
--
R
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
M
-
G
-
F
E
E
E
V
E
A
L
L
S
A
--
T
----
P
-------
P
S
--
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
54.77
37%
-21
- C1 -
4PX9
1
DDX3X_HUMAN
B:
[67-282]
---
F
S
D
V
E
M
G
E
I
I
M
G
N
I
-
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
Y
S
D
GPGEA
L
R
---
A
M
K
------------------
E
---------
N
---
G
RYG
R
R
K
Q
Y
P
I
S
-
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
-
Y
-
R
-
S
----
R
---
V
R
-
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
-
E
R
G
--
C
-
H
L
L
V
A
T
P
G
R
L
V
D
M
M
-
E
--
R
-
G
---
K
I
G
L
D
--
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
-
D
M
-
G
-
F
E
P
Q
I
R
R
I
V
E
Q
DT
M
----
P
-------
P
K
GV
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
54.42
37%
-21
- C1 -
4PX9
1
DDX3X_HUMAN
C:
[67-282]
---
F
S
D
V
E
M
G
E
I
I
M
G
N
I
-
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
QIYSDGPGEA
L
R
---
A
M
K
------------------
E
---------
N
---
G
RYGRRKQY
P
I
S
-
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
-
Y
-
R
-
S
----
R
---
V
R
-
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
-
E
R
G
--
C
-
H
L
L
V
A
T
P
G
R
L
V
D
M
M
-
E
--
R
-
G
---
K
I
G
L
D
--
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
-
D
M
-
G
-
F
E
P
Q
I
R
R
I
V
E
Q
DT
M
----
P
-------
P
K
GV
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
54.37
37%
-21
- C1 -
4PX9
1
DDX3X_HUMAN
A:
[67-282]
---
F
S
D
V
E
M
G
E
I
I
M
G
N
I
-
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
Y
S
D
GPGEA
L
R
---
A
M
K
------------------
E
---------
N
---
G
RYG
R
R
K
Q
Y
P
I
S
-
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
-
Y
-
R
-
S
----
R
---
V
R
-
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
-
E
R
G
--
C
-
H
L
L
V
A
T
P
G
R
L
V
D
M
M
-
E
--
R
-
G
---
K
I
G
L
D
--
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
-
D
M
-
G
-
F
E
P
Q
I
R
R
I
V
E
Q
DT
M
----
P
-------
P
K
GV
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
52.20
33%
-15
- C1 -
3FMO
1
DD19B_HUMAN
B:
[94-298]
---
F
E
E
L
R
L
K
P
Q
L
L
Q
G
V
-
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
A
--
E
P
P
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
----------
Q
V
---
E
P
A
------------------
N
---------
K
---
Y
--------
P
Q
C
-
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
-
K
-
F
Y
P
----
E
---
L
K
L
A
Y
A
V
R
G
N
------
K
L
E
R
-
G
Q
K
IS
E
-
Q
I
V
I
G
T
P
G
T
V
L
D
W
C
-
S
--
K
-
L
---
K
F
-
I
D
PK
K
I
K
V
F
V
L
D
E
A
D
V
M
I
A
T
Q
-
G
-
H
Q
D
Q
S
I
R
I
Q
R
M
--
L
----
P
-------
R
N
--
C
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
V
I
K
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
50.22
34%
3
- C1 -
3FE2
4
DDX5_HUMAN
B:
[30-239]
--
N
F
Y
E
A
N
F
P
A
N
V
M
D
V
I
-
A
R
Q
N
F
T
E
P
T
A
I
Q
A
Q
G
W
P
V
A
L
S
--
G
--
L
D
M
V
G
V
A
Q
T
G
S
G
K
T
L
S
Y
L
L
P
A
I
V
----------
H
I
---
N
H
Q
------------------
P
FLERG----
D
---
G
--------
P
I
C
-
L
V
L
A
P
T
R
E
L
A
Q
Q
V
Q
Q
V
A
A
E
Y
C
-
R
-
A
-
C
----
R
---
L
K
-
S
T
C
I
Y
G
G
A
P
K
G
P
Q
I
R
D
L
-
E
R
G
--
V
-
E
I
C
I
A
T
P
G
R
L
I
D
F
L
-
E
--
C
-
G
---
K
T
N
L
R
--
R
T
T
Y
L
V
L
D
E
A
D
R
M
L
-
D
M
-
G
-
F
E
P
Q
I
R
K
I
V
D
Q
--
I
----
R
-------
P
D
--
R
Q
T
L
M
W
S
A
T
W
P
K
E
V
R
Q
L
A
E
D
F
L
K
D
Y
I
H
I
N
I
G
-
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
49.19
34%
7
- C1 -
3FE2
3
DDX5_HUMAN
A:
[30-239]
--
N
F
Y
E
A
N
F
P
A
N
V
M
D
V
I
-
A
R
Q
N
F
T
E
P
T
A
I
Q
A
Q
G
W
P
V
A
L
S
--
G
--
L
D
M
V
G
V
A
Q
T
G
S
G
K
T
L
S
Y
L
L
P
A
I
V
----------
H
I
---
N
H
Q
------------------
P
FLERG----
D
---
G
--------
P
I
C
-
L
V
L
A
P
T
R
E
L
A
Q
Q
V
Q
Q
V
A
A
E
Y
C
-
R
-
A
-
C
----
R
---
L
K
-
S
T
C
I
Y
G
G
A
P
K
G
P
Q
I
R
D
L
-
E
R
G
--
V
-
E
I
C
I
A
T
P
G
R
L
I
D
F
L
-
E
--
C
-
G
---
K
T
N
L
R
--
R
T
T
Y
L
V
L
D
E
A
D
R
M
L
-
D
M
-
G
-
F
E
P
Q
I
R
K
I
V
D
Q
--
I
----
R
-------
P
D
--
R
Q
T
L
M
W
S
A
T
W
P
K
E
V
R
Q
L
A
E
D
F
L
K
D
Y
I
H
I
N
I
G
-
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
46.79
35%
-1
- C1 -
2PL3
6
DDX10_HUMAN
A:
[24-232]
I
T
R
F
S
D
F
P
L
S
K
K
T
L
K
G
L
-
Q
E
A
Q
Y
R
L
V
T
E
I
Q
K
Q
T
I
G
L
A
L
Q
--
G
--
K
D
V
L
G
A
A
K
T
G
S
G
K
T
L
A
F
L
V
P
V
L
E
----------
A
L
Y
R
L
Q
W
T
------------------
S
---------
T
---
D
--------
G
L
G
V
L
I
I
S
P
T
R
E
L
A
Y
Q
T
F
E
V
L
R
K
V
G
-
K
-
N
-
H
----
D
---
F
S
-
A
G
L
I
I
G
G
--
L
-
K
H
E
A
E
R
-
I
N
N
--
I
-
N
I
L
V
C
T
P
G
R
L
L
Q
H
M
D
E
--
T
-
V
---
S
F
H
A
T
--
D
L
Q
M
L
V
L
D
E
A
D
R
I
L
-
D
M
-
G
-
F
A
D
T
M
N
A
V
I
E
N
--
L
----
P
-------
K
K
--
R
Q
T
L
L
F
S
A
T
Q
T
K
S
V
K
D
L
A
R
L
S
L
K
N
P
E
Y
V
W
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------