@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu39360: (2016-08-05 )
MTDVKKSIRANRGTELECLGWEQEAVLRMLRNNLDPEVAEKPEDLIVYGGIGKAARDWDAFHAIEHSLKTLKNDETLLVQSGKPVGMFRTHPQAPRVLLANSVLVPKWADWEHFHELEKKGLMMYGQMTAGSWIYIGSQGILQGTYETFAELARQHFGGSLKGTLTLTAGLGGMGGAQPLSVTMNEGVVIAVEVDEKRIDKRIETKYCDRKTASIEEALAWAEEAKLAGKPLSIALLGNAAEVHHTLLNRGVKIDIVTDQTSAHDPLIGYVPEGYSLDEADRLRQDTPELYVRLAKQSMKKHVEAMLAFQQKGSIVFDYGNNIRQVAKDEGLENAFDFPGFVPAYIRPLFCEGKGPFRWAALSGDPADIYRTDALLKELFPTNKALHRWIDMAQEKVTFQGLPSRICWLGYGERKKMGLAINELVRTGELKAPVVIGRDHLDCGSVASPNRETEAMKDGSDAVGDWAVLNALVNTAAGASWVSFHHGGGVGMGYSLHAGMVAVADGSELADERLARVLTSDPGMGIIRHADAGYERAVEVAKEQDIIVPMQK
Atome Classification :
(20 SA)
-......----...10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-MT
D
V
K
K
----
S
I
RANRGT
E
L
E
C
LGW
E
Q
E
A
V
L
R
M
L
RNNL
D
P
E
VAEKPE
D
L
I
V
YGGIGKAA
R
D
W
D
A
F
H
A
I
E
H
S
L
K
T
LKND
E
T
L
L
VQSGKPV
G
M
FRTHPQAP
R
V
L
L
ANSVLVPKWA
D
W
E
H
F
H
E
L
E
KKG
L
M
M
Y
G
QMTAG
S
W
I
Y
IGSQGIL
Q
G
T
Y
E
T
F
A
E
L
A
R
Q
HFGGS
L
K
G
T
L
T
L
T
AGLGGMGGA
Q
P
L
S
V
T
MNE
G
V
V
I
A
V
EV
D
E
K
R
I
D
K
R
I
E
T
K
YCDRKT
A
S
I
E
E
A
L
A
W
A
E
E
AKLAGK
P
L
S
I
A
L
LG
N
A
A
E
V
H
H
T
L
L
NRG
V
K
I
D
I
V
TDQTSAHDP
L
I
G
YVPEGYSL
D
E
A
D
R
L
R
QD
T
P
E
L
Y
V
R
L
A
K
Q
S
M
K
K
H
V
E
A
M
L
A
F
Q
QKG
S
I
V
F
DYGN
N
I
R
Q
V
A
K
DEGLENAFDFPGF
V
P
A
Y
I
R
P
L
F
CEGKGP
F
R
W
AALSG
D
P
A
D
I
Y
R
T
D
A
L
L
K
E
LFPT
N
K
A
L
H
R
W
I
D
M
A
Q
E
K
V
TFQGLPS
R
I
C
WLGYGERKK
M
G
L
A
I
N
E
L
V
RTGELKA
P
V
V
I
GRDHLDCGSVASPNR
E
T
E
AMKDGSDAV
G
D
W
A
V
L
N
A
L
V
NTAAGA
S
W
V
S
F
HHGGGVGMGYSLHA
G
M
V
A
VAD
G
S
E
L
A
D
E
R
L
A
R
V
L
TSDPGM
G
I
I
RHADA
G
Y
E
R
A
V
E
V
AKEQ
D
I
IVPMQK-
8
PsiBlast_CBE
94.26
100%
-62
- C4 -
2FKN
2
HUTU_BACSU
D:
[7-550]
-----------
S
I
R
A
N
R
G
T
E
L
E
C
L
G
W
E
Q
E
A
V
L
R
M
L
R
N
N
L
D
P
E
V
A
E
K
P
E
D
L
I
V
Y
G
G
I
G
K
A
A
R
D
W
D
A
F
H
A
I
E
H
S
L
K
T
L
K
N
D
E
T
L
L
V
Q
S
G
K
P
V
G
M
F
R
T
H
P
Q
A
P
R
V
L
L
A
N
S
V
L
V
P
K
W
A
D
W
E
H
F
H
E
L
E
K
K
G
L
M
M
Y
G
Q
M
T
A
G
S
W
I
Y
I
G
S
Q
G
I
L
Q
G
T
Y
E
T
F
A
E
L
A
R
Q
H
F
G
G
S
L
K
G
T
L
T
L
T
A
G
L
G
G
M
G
G
A
Q
P
L
S
V
T
M
N
E
G
V
V
I
A
V
E
V
D
E
K
R
I
D
K
R
I
E
T
K
Y
C
D
R
K
T
A
S
I
E
E
A
L
A
W
A
E
E
A
K
L
A
G
K
P
L
S
I
A
L
L
G
N
A
A
E
V
H
H
T
L
L
N
R
G
V
K
I
D
I
V
T
D
Q
T
S
A
H
D
P
L
I
G
Y
V
P
E
G
Y
S
L
D
E
A
D
R
L
R
Q
D
T
P
E
L
Y
V
R
L
A
K
Q
S
M
K
K
H
V
E
A
M
L
A
F
Q
Q
K
G
S
I
V
F
D
Y
G
N
N
I
R
Q
V
A
K
D
E
G
L
E
N
A
F
D
F
P
G
F
V
P
A
Y
I
R
P
L
F
C
E
G
K
G
P
F
R
W
A
A
L
S
G
D
P
A
D
I
Y
R
T
D
A
L
L
K
E
L
F
P
T
N
K
A
L
H
R
W
I
D
M
A
Q
E
K
V
T
F
Q
G
L
P
S
R
I
C
W
L
G
Y
G
E
R
K
K
M
G
L
A
I
N
E
L
V
R
T
G
E
L
K
A
P
V
V
I
G
R
D
H
L
D
C
G
S
V
A
S
P
N
R
E
T
E
A
M
K
D
G
S
D
A
V
G
D
W
A
V
L
N
A
L
V
N
T
A
A
G
A
S
W
V
S
F
H
H
G
G
G
V
G
M
G
Y
S
L
H
A
G
M
V
A
V
A
D
G
S
E
L
A
D
E
R
L
A
R
V
L
T
S
D
P
G
M
G
I
I
R
H
A
D
A
G
Y
E
R
A
V
E
V
A
K
E
Q
D
I
I
V
P
M
---
9
PsiBlast_CBE
94.07
100%
-60
- C4 -
2FKN
2
HUTU_BACSU
C:
[7-550]
-----------
S
I
R
A
N
R
G
T
E
L
E
C
L
G
W
E
Q
E
A
V
L
R
M
L
R
N
N
L
D
P
E
V
A
E
K
P
E
D
L
I
V
Y
G
G
I
G
K
A
A
R
D
W
D
A
F
H
A
I
E
H
S
L
K
T
L
K
N
D
E
T
L
L
V
Q
S
G
K
P
V
G
M
F
R
T
H
P
Q
A
P
R
V
L
L
A
N
S
V
L
V
P
K
W
A
D
W
E
H
F
H
E
L
E
K
K
G
L
M
M
Y
G
Q
M
T
A
G
S
W
I
Y
I
G
S
Q
G
I
L
Q
G
T
Y
E
T
F
A
E
L
A
R
Q
H
F
G
G
S
L
K
G
T
L
T
L
T
A
G
L
G
G
M
G
G
A
Q
P
L
S
V
T
M
N
E
G
V
V
I
A
V
E
V
D
E
K
R
I
D
K
R
I
E
T
K
Y
C
D
R
K
T
A
S
I
E
E
A
L
A
W
A
E
E
A
K
L
A
G
K
P
L
S
I
A
L
L
G
N
A
A
E
V
H
H
T
L
L
N
R
G
V
K
I
D
I
V
T
D
Q
T
S
A
H
D
P
L
I
G
Y
V
P
E
G
Y
S
L
D
E
A
D
R
L
R
Q
D
T
P
E
L
Y
V
R
L
A
K
Q
S
M
K
K
H
V
E
A
M
L
A
F
Q
Q
K
G
S
I
V
F
D
Y
G
N
N
I
R
Q
V
A
K
D
E
G
L
E
N
A
F
D
F
P
G
F
V
P
A
Y
I
R
P
L
F
C
E
G
K
G
P
F
R
W
A
A
L
S
G
D
P
A
D
I
Y
R
T
D
A
L
L
K
E
L
F
P
T
N
K
A
L
H
R
W
I
D
M
A
Q
E
K
V
T
F
Q
G
L
P
S
R
I
C
W
L
G
Y
G
E
R
K
K
M
G
L
A
I
N
E
L
V
R
T
G
E
L
K
A
P
V
V
I
G
R
D
H
L
D
C
G
S
V
A
S
P
N
R
E
T
E
A
M
K
D
G
S
D
A
V
G
D
W
A
V
L
N
A
L
V
N
T
A
A
G
A
S
W
V
S
F
H
H
G
G
G
V
G
M
G
Y
S
L
H
A
G
M
V
A
V
A
D
G
S
E
L
A
D
E
R
L
A
R
V
L
T
S
D
P
G
M
G
I
I
R
H
A
D
A
G
Y
E
R
A
V
E
V
A
K
E
Q
D
I
I
V
P
M
---
17
HHSearch
93.89
100%
-62
- C4 -
2FKN
2
HUTU_BACSU
A:
[7-550]
-----------
S
I
R
A
N
R
G
T
E
L
E
C
L
G
W
E
Q
E
A
V
L
R
M
L
R
N
N
L
D
P
E
V
A
E
K
P
E
D
L
I
V
Y
G
G
I
G
K
A
A
R
D
W
D
A
F
H
A
I
E
H
S
L
K
T
L
K
N
D
E
T
L
L
V
Q
S
G
K
P
V
G
M
F
R
T
H
P
Q
A
P
R
V
L
L
A
N
S
V
L
V
P
K
W
A
D
W
E
H
F
H
E
L
E
K
K
G
L
M
M
Y
G
Q
M
T
A
G
S
W
I
Y
I
G
S
Q
G
I
L
Q
G
T
Y
E
T
F
A
E
L
A
R
Q
H
F
G
G
S
L
K
G
T
L
T
L
T
A
G
L
G
G
M
G
G
A
Q
P
L
S
V
T
M
N
E
G
V
V
I
A
V
E
V
D
E
K
R
I
D
K
R
I
E
T
K
Y
C
D
R
K
T
A
S
I
E
E
A
L
A
W
A
E
E
A
K
L
A
G
K
P
L
S
I
A
L
L
G
N
A
A
E
V
H
H
T
L
L
N
R
G
V
K
I
D
I
V
T
D
Q
T
S
A
H
D
P
L
I
G
Y
V
P
E
G
Y
S
L
D
E
A
D
R
L
R
Q
D
T
P
E
L
Y
V
R
L
A
K
Q
S
M
K
K
H
V
E
A
M
L
A
F
Q
Q
K
G
S
I
V
F
D
Y
G
N
N
I
R
Q
V
A
K
D
E
G
L
E
N
A
F
D
F
P
G
F
V
P
A
Y
I
R
P
L
F
C
E
G
K
G
P
F
R
W
A
A
L
S
G
D
P
A
D
I
Y
R
T
D
A
L
L
K
E
L
F
P
T
N
K
A
L
H
R
W
I
D
M
A
Q
E
K
V
T
F
Q
G
L
P
S
R
I
C
W
L
G
Y
G
E
R
K
K
M
G
L
A
I
N
E
L
V
R
T
G
E
L
K
A
P
V
V
I
G
R
D
H
L
D
C
G
S
V
A
S
P
N
R
E
T
E
A
M
K
D
G
S
D
A
V
G
D
W
A
V
L
N
A
L
V
N
T
A
A
G
A
S
W
V
S
F
H
H
G
G
G
V
G
M
G
Y
S
L
H
A
G
M
V
A
V
A
D
G
S
E
L
A
D
E
R
L
A
R
V
L
T
S
D
P
G
M
G
I
I
R
H
A
D
A
G
Y
E
R
A
V
E
V
A
K
E
Q
D
I
I
V
P
M
---
1
PsiBlast_PDB
93.89
100%
-62
- C4 -
2FKN
2
HUTU_BACSU
A:
[7-550]
-----------
S
I
R
A
N
R
G
T
E
L
E
C
L
G
W
E
Q
E
A
V
L
R
M
L
R
N
N
L
D
P
E
V
A
E
K
P
E
D
L
I
V
Y
G
G
I
G
K
A
A
R
D
W
D
A
F
H
A
I
E
H
S
L
K
T
L
K
N
D
E
T
L
L
V
Q
S
G
K
P
V
G
M
F
R
T
H
P
Q
A
P
R
V
L
L
A
N
S
V
L
V
P
K
W
A
D
W
E
H
F
H
E
L
E
K
K
G
L
M
M
Y
G
Q
M
T
A
G
S
W
I
Y
I
G
S
Q
G
I
L
Q
G
T
Y
E
T
F
A
E
L
A
R
Q
H
F
G
G
S
L
K
G
T
L
T
L
T
A
G
L
G
G
M
G
G
A
Q
P
L
S
V
T
M
N
E
G
V
V
I
A
V
E
V
D
E
K
R
I
D
K
R
I
E
T
K
Y
C
D
R
K
T
A
S
I
E
E
A
L
A
W
A
E
E
A
K
L
A
G
K
P
L
S
I
A
L
L
G
N
A
A
E
V
H
H
T
L
L
N
R
G
V
K
I
D
I
V
T
D
Q
T
S
A
H
D
P
L
I
G
Y
V
P
E
G
Y
S
L
D
E
A
D
R
L
R
Q
D
T
P
E
L
Y
V
R
L
A
K
Q
S
M
K
K
H
V
E
A
M
L
A
F
Q
Q
K
G
S
I
V
F
D
Y
G
N
N
I
R
Q
V
A
K
D
E
G
L
E
N
A
F
D
F
P
G
F
V
P
A
Y
I
R
P
L
F
C
E
G
K
G
P
F
R
W
A
A
L
S
G
D
P
A
D
I
Y
R
T
D
A
L
L
K
E
L
F
P
T
N
K
A
L
H
R
W
I
D
M
A
Q
E
K
V
T
F
Q
G
L
P
S
R
I
C
W
L
G
Y
G
E
R
K
K
M
G
L
A
I
N
E
L
V
R
T
G
E
L
K
A
P
V
V
I
G
R
D
H
L
D
C
G
S
V
A
S
P
N
R
E
T
E
A
M
K
D
G
S
D
A
V
G
D
W
A
V
L
N
A
L
V
N
T
A
A
G
A
S
W
V
S
F
H
H
G
G
G
V
G
M
G
Y
S
L
H
A
G
M
V
A
V
A
D
G
S
E
L
A
D
E
R
L
A
R
V
L
T
S
D
P
G
M
G
I
I
R
H
A
D
A
G
Y
E
R
A
V
E
V
A
K
E
Q
D
I
I
V
P
M
---
10
PsiBlast_CBE
93.77
100%
-65
- C4 -
2FKN
2
HUTU_BACSU
B:
[7-552]
-----------
S
I
R
A
N
R
G
T
E
L
E
C
L
G
W
E
Q
E
A
V
L
R
M
L
R
N
N
L
D
P
E
V
A
E
K
P
E
D
L
I
V
Y
G
G
I
G
K
A
A
R
D
W
D
A
F
H
A
I
E
H
S
L
K
T
L
K
N
D
E
T
L
L
V
Q
S
G
K
P
V
G
M
F
R
T
H
P
Q
A
P
R
V
L
L
A
N
S
V
L
V
P
K
W
A
D
W
E
H
F
H
E
L
E
K
K
G
L
M
M
Y
G
Q
M
T
A
G
S
W
I
Y
I
G
S
Q
G
I
L
Q
G
T
Y
E
T
F
A
E
L
A
R
Q
H
F
G
G
S
L
K
G
T
L
T
L
T
A
G
L
G
G
M
G
G
A
Q
P
L
S
V
T
M
N
E
G
V
V
I
A
V
E
V
D
E
K
R
I
D
K
R
I
E
T
K
Y
C
D
R
K
T
A
S
I
E
E
A
L
A
W
A
E
E
A
K
L
A
G
K
P
L
S
I
A
L
L
G
N
A
A
E
V
H
H
T
L
L
N
R
G
V
K
I
D
I
V
T
D
Q
T
S
A
H
D
P
L
I
G
Y
V
P
E
G
Y
S
L
D
E
A
D
R
L
R
Q
D
T
P
E
L
Y
V
R
L
A
K
Q
S
M
K
K
H
V
E
A
M
L
A
F
Q
Q
K
G
S
I
V
F
D
Y
G
N
N
I
R
Q
V
A
K
D
E
G
L
E
N
A
F
D
F
P
G
F
V
P
A
Y
I
R
P
L
F
C
E
G
K
G
P
F
R
W
A
A
L
S
G
D
P
A
D
I
Y
R
T
D
A
L
L
K
E
L
F
P
T
N
K
A
L
H
R
W
I
D
M
A
Q
E
K
V
T
F
Q
G
L
P
S
R
I
C
W
L
G
Y
G
E
R
K
K
M
G
L
A
I
N
E
L
V
R
T
G
E
L
K
A
P
V
V
I
G
R
D
H
L
D
C
G
S
V
A
S
P
N
R
E
T
E
A
M
K
D
G
S
D
A
V
G
D
W
A
V
L
N
A
L
V
N
T
A
A
G
A
S
W
V
S
F
H
H
G
G
G
V
G
M
G
Y
S
L
H
A
G
M
V
A
V
A
D
G
S
E
L
A
D
E
R
L
A
R
V
L
T
S
D
P
G
M
G
I
I
R
H
A
D
A
G
Y
E
R
A
V
E
V
A
K
E
Q
D
I
I
V
P
M
Q
K
-
11
PsiBlast_CBE
82.55
64%
-65
- C4 -
1UWL
1
HUTU_PSEPU
B:
[12-554]
------------
I
R
A
P
R
G
N
K
L
T
A
K
S
W
L
T
E
A
P
L
R
M
L
M
N
N
L
D
P
Q
V
A
E
N
P
K
E
L
V
V
Y
G
G
I
G
R
A
A
R
N
W
E
C
Y
D
K
I
V
E
T
L
T
R
L
E
D
D
E
T
L
L
V
Q
S
G
K
P
V
G
V
F
K
T
H
S
N
A
P
R
V
L
I
A
N
S
N
L
V
P
H
W
A
N
W
E
H
F
N
E
L
D
A
K
G
L
A
M
Y
G
Q
M
T
A
G
S
W
I
Y
I
G
S
Q
G
I
V
Q
G
T
Y
E
T
F
V
E
A
G
R
Q
H
Y
G
G
S
L
K
G
K
W
V
L
T
A
G
L
G
G
M
G
G
A
Q
P
L
A
A
T
L
A
G
A
C
S
L
N
I
E
S
Q
Q
S
R
I
D
F
R
L
E
T
R
Y
V
D
E
Q
A
T
D
L
D
D
A
L
V
R
I
A
K
Y
T
A
E
G
K
A
I
S
I
A
L
H
G
N
A
A
E
I
L
P
E
L
V
K
R
G
V
R
P
D
M
V
T
D
Q
T
S
A
H
D
P
L
N
G
Y
L
P
A
G
W
T
W
E
Q
Y
R
D
R
A
Q
T
E
P
A
A
V
V
K
A
A
K
Q
S
M
A
V
H
V
Q
A
M
L
D
F
Q
K
Q
G
V
P
T
F
D
Y
G
N
N
I
R
Q
M
A
K
E
E
G
V
A
N
A
F
D
F
P
G
F
V
P
A
Y
I
R
P
L
F
C
R
G
V
G
P
F
R
W
A
A
L
S
G
E
A
E
D
I
Y
K
T
D
A
K
V
K
E
L
I
P
D
D
A
H
L
H
R
W
L
D
M
A
R
E
R
I
S
F
Q
G
L
P
A
R
I
C
W
V
G
L
G
L
R
A
K
L
G
L
A
F
N
E
M
V
R
S
G
E
L
S
A
P
V
V
I
G
R
D
H
L
D
S
G
S
V
S
S
P
N
R
E
T
E
A
M
R
D
G
S
D
A
V
S
D
W
P
L
L
N
A
L
L
N
T
A
G
G
A
T
W
V
S
L
H
H
G
G
G
V
G
M
G
F
S
Q
H
S
G
M
V
I
V
C
D
G
T
D
E
A
A
E
R
I
A
R
V
L
T
N
D
P
G
T
G
V
M
R
H
A
D
A
G
Y
D
I
A
I
D
C
A
K
E
Q
G
L
D
L
P
M
---
3
PsiBlast_PDB
82.00
64%
-62
- C4 -
1W1U
2
HUTU_PSEPU
A:
[12-554]
------------
I
R
A
P
R
G
N
K
L
T
A
K
S
W
L
T
E
A
P
L
R
M
L
M
N
N
L
D
P
Q
V
A
E
N
P
K
E
L
V
V
Y
G
G
I
G
R
A
A
R
N
W
E
C
Y
D
K
I
V
E
T
L
T
R
L
E
D
D
E
T
L
L
V
Q
S
G
K
P
V
G
V
F
K
T
H
S
N
A
P
R
V
L
I
A
N
S
N
L
V
P
H
W
A
N
W
E
H
F
N
E
L
D
A
K
G
L
A
M
Y
G
Q
M
T
A
G
S
W
I
Y
I
G
S
Q
G
I
V
Q
G
T
Y
E
T
F
V
E
A
G
R
Q
H
Y
G
G
S
L
K
G
K
W
V
L
T
A
G
L
G
G
M
G
G
A
Q
P
L
A
A
T
L
A
G
A
C
S
L
N
I
E
S
Q
Q
S
R
I
D
F
R
L
E
T
R
Y
V
D
E
Q
A
T
D
L
D
D
A
L
V
R
I
A
K
Y
T
A
E
G
K
A
I
S
I
A
L
H
G
N
A
A
E
I
L
P
E
L
V
K
R
G
V
R
P
D
M
V
T
D
Q
T
S
A
H
D
P
L
N
G
Y
L
P
A
G
W
T
W
E
Q
Y
R
D
R
A
Q
T
E
P
A
A
V
V
K
A
A
K
Q
S
M
A
V
H
V
Q
A
M
L
D
F
Q
K
Q
G
V
P
T
F
D
Y
G
N
N
I
R
Q
M
A
K
E
E
G
V
A
N
A
F
D
F
P
G
F
V
P
A
Y
I
R
P
L
F
C
R
G
V
G
P
F
R
W
A
A
L
S
G
E
A
E
D
I
Y
K
T
D
A
K
V
K
E
L
I
P
D
D
A
H
L
H
R
W
L
D
M
A
R
E
R
I
S
F
Q
G
L
P
A
R
I
C
W
V
G
L
G
L
R
A
K
L
G
L
A
F
N
E
M
V
R
S
G
E
L
S
A
P
V
V
I
G
R
D
H
L
D
S
G
S
V
S
S
P
N
A
E
T
E
A
M
R
D
G
S
D
A
V
S
D
W
P
L
L
N
A
L
L
N
T
A
G
G
A
T
W
V
S
L
H
H
G
G
G
V
G
M
G
F
S
Q
H
S
G
M
V
I
V
C
D
G
T
D
E
A
A
E
R
I
A
R
V
L
T
N
D
P
G
T
G
V
M
R
H
A
D
A
G
Y
D
I
A
I
D
C
A
K
E
Q
G
L
D
L
P
M
---
19
HHSearch
81.86
63%
-61
- C4 -
1UWK
2
HUTU_PSEPU
A:
[6-555]
--
K
Y
R
D
V
----
E
I
R
A
P
R
G
N
K
L
T
A
K
S
W
L
T
E
A
P
L
R
M
L
M
N
N
L
D
P
Q
V
A
E
N
P
K
E
L
V
V
Y
G
G
I
G
R
A
A
R
N
W
E
C
Y
D
K
I
V
E
T
L
T
R
L
E
D
D
E
T
L
L
V
Q
S
G
K
P
V
G
V
F
K
T
H
S
N
A
P
R
V
L
I
A
N
S
N
L
V
P
H
W
A
N
W
E
H
F
N
E
L
D
A
K
G
L
A
M
Y
G
Q
M
T
A
G
S
W
I
Y
I
G
S
Q
G
I
V
Q
G
T
Y
E
T
F
V
E
A
G
R
Q
H
Y
G
G
S
L
K
G
K
W
V
L
T
A
G
L
G
G
M
G
G
A
Q
P
L
A
A
T
L
A
G
A
C
S
L
N
I
E
S
Q
Q
S
R
I
D
F
R
L
E
T
R
Y
V
D
E
Q
A
T
D
L
D
D
A
L
V
R
I
A
K
Y
T
A
E
G
K
A
I
S
I
A
L
H
G
N
A
A
E
I
L
P
E
L
V
K
R
G
V
R
P
D
M
V
T
D
Q
T
S
A
H
D
P
L
N
G
Y
L
P
A
G
W
T
W
E
Q
Y
R
D
R
A
Q
T
E
P
A
A
V
V
K
A
A
K
Q
S
M
A
V
H
V
Q
A
M
L
D
F
Q
K
Q
G
V
P
T
F
D
Y
G
N
N
I
R
Q
M
A
K
E
E
G
V
A
D
A
F
D
F
P
G
F
V
P
A
Y
I
R
P
L
F
C
R
G
V
G
P
F
R
W
A
A
L
S
G
E
A
E
D
I
Y
K
T
D
A
K
V
K
E
L
I
P
D
D
A
H
L
H
R
W
L
D
M
A
R
E
R
I
S
F
Q
G
L
P
A
R
I
C
W
V
G
L
G
L
R
A
K
L
G
L
A
F
N
E
M
V
R
S
G
E
L
S
A
P
V
V
I
G
R
D
H
L
D
S
G
S
V
S
S
P
N
A
E
T
E
A
M
R
D
G
S
D
A
V
S
D
W
P
L
L
N
A
L
L
N
T
A
G
G
A
T
W
V
S
L
H
H
G
G
G
V
G
M
G
F
S
Q
H
S
G
M
V
I
V
C
D
G
T
D
E
A
A
E
R
I
A
R
V
L
T
N
D
P
G
T
G
V
M
R
H
A
D
A
G
Y
D
I
A
I
D
C
A
K
E
Q
G
L
D
L
P
M
I
--
12
PsiBlast_CBE
81.73
64%
-63
- C4 -
1W1U
2
HUTU_PSEPU
B:
[12-554]
------------
I
R
A
P
R
G
N
K
L
T
A
K
S
W
L
T
E
A
P
L
R
M
L
M
N
N
L
D
P
Q
V
A
E
N
P
K
E
L
V
V
Y
G
G
I
G
R
A
A
R
N
W
E
C
Y
D
K
I
V
E
T
L
T
R
L
E
D
D
E
T
L
L
V
Q
S
G
K
P
V
G
V
F
K
T
H
S
N
A
P
R
V
L
I
A
N
S
N
L
V
P
H
W
A
N
W
E
H
F
N
E
L
D
A
K
G
L
A
M
Y
G
Q
M
T
A
G
S
W
I
Y
I
G
S
Q
G
I
V
Q
G
T
Y
E
T
F
V
E
A
G
R
Q
H
Y
G
G
S
L
K
G
K
W
V
L
T
A
G
L
G
G
M
G
G
A
Q
P
L
A
A
T
L
A
G
A
C
S
L
N
I
E
S
Q
Q
S
R
I
D
F
R
L
E
T
R
Y
V
D
E
Q
A
T
D
L
D
D
A
L
V
R
I
A
K
Y
T
A
E
G
K
A
I
S
I
A
L
H
G
N
A
A
E
I
L
P
E
L
V
K
R
G
V
R
P
D
M
V
T
D
Q
T
S
A
H
D
P
L
N
G
Y
L
P
A
G
W
T
W
E
Q
Y
R
D
R
A
Q
T
E
P
A
A
V
V
K
A
A
K
Q
S
M
A
V
H
V
Q
A
M
L
D
F
Q
K
Q
G
V
P
T
F
D
Y
G
N
N
I
R
Q
M
A
K
E
E
G
V
A
N
A
F
D
F
P
G
F
V
P
A
Y
I
R
P
L
F
C
R
G
V
G
P
F
R
W
A
A
L
S
G
E
A
E
D
I
Y
K
T
D
A
K
V
K
E
L
I
P
D
D
A
H
L
H
R
W
L
D
M
A
R
E
R
I
S
F
Q
G
L
P
A
R
I
C
W
V
G
L
G
L
R
A
K
L
G
L
A
F
N
E
M
V
R
S
G
E
L
S
A
P
V
V
I
G
R
D
H
L
D
S
G
S
V
S
S
P
N
A
E
T
E
A
M
R
D
G
S
D
A
V
S
D
W
P
L
L
N
A
L
L
N
T
A
G
G
A
T
W
V
S
L
H
H
G
G
G
V
G
M
G
F
S
Q
H
S
G
M
V
I
V
C
D
G
T
D
E
A
A
E
R
I
A
R
V
L
T
N
D
P
G
T
G
V
M
R
H
A
D
A
G
Y
D
I
A
I
D
C
A
K
E
Q
G
L
D
L
P
M
---
2
PsiBlast_PDB
81.71
64%
-60
- C4 -
1UWL
1
HUTU_PSEPU
A:
[12-554]
------------
I
R
A
P
R
G
N
K
L
T
A
K
S
W
L
T
E
A
P
L
R
M
L
M
N
N
L
D
P
Q
V
A
E
N
P
K
E
L
V
V
Y
G
G
I
G
R
A
A
R
N
W
E
C
Y
D
K
I
V
E
T
L
T
R
L
E
D
D
E
T
L
L
V
Q
S
G
K
P
V
G
V
F
K
T
H
S
N
A
P
R
V
L
I
A
N
S
N
L
V
P
H
W
A
N
W
E
H
F
N
E
L
D
A
K
G
L
A
M
Y
G
Q
M
T
A
G
S
W
I
Y
I
G
S
Q
G
I
V
Q
G
T
Y
E
T
F
V
E
A
G
R
Q
H
Y
G
G
S
L
K
G
K
W
V
L
T
A
G
L
G
G
M
G
G
A
Q
P
L
A
A
T
L
A
G
A
C
S
L
N
I
E
S
Q
Q
S
R
I
D
F
R
L
E
T
R
Y
V
D
E
Q
A
T
D
L
D
D
A
L
V
R
I
A
K
Y
T
A
E
G
K
A
I
S
I
A
L
H
G
N
A
A
E
I
L
P
E
L
V
K
R
G
V
R
P
D
M
V
T
D
Q
T
S
A
H
D
P
L
N
G
Y
L
P
A
G
W
T
W
E
Q
Y
R
D
R
A
Q
T
E
P
A
A
V
V
K
A
A
K
Q
S
M
A
V
H
V
Q
A
M
L
D
F
Q
K
Q
G
V
P
T
F
D
Y
G
N
N
I
R
Q
M
A
K
E
E
G
V
A
N
A
F
D
F
P
G
F
V
P
A
Y
I
R
P
L
F
C
R
G
V
G
P
F
R
W
A
A
L
S
G
E
A
E
D
I
Y
K
T
D
A
K
V
K
E
L
I
P
D
D
A
H
L
H
R
W
L
D
M
A
R
E
R
I
S
F
Q
G
L
P
A
R
I
C
W
V
G
L
G
L
R
A
K
L
G
L
A
F
N
E
M
V
R
S
G
E
L
S
A
P
V
V
I
G
R
D
H
L
D
S
G
S
V
S
S
P
N
R
E
T
E
A
M
R
D
G
S
D
A
V
S
D
W
P
L
L
N
A
L
L
N
T
A
G
G
A
T
W
V
S
L
H
H
G
G
G
V
G
M
G
F
S
Q
H
S
G
M
V
I
V
C
D
G
T
D
E
A
A
E
R
I
A
R
V
L
T
N
D
P
G
T
G
V
M
R
H
A
D
A
G
Y
D
I
A
I
D
C
A
K
E
Q
G
L
D
L
P
M
---
38
Fugue
75.59
63%
-2
- C4 -
1UWK
2
HUTU_PSEPU
A:
[4-557]
N
N
K
Y
R
D
V
----
E
I
R
A
P
R
G
N
K
L
T
A
K
S
W
L
T
E
A
P
L
R
M
L
M
N
N
L
D
P
Q
V
A
E
N
P
K
E
L
V
V
Y
G
G
I
G
R
A
A
R
N
W
E
C
Y
D
K
I
V
E
T
L
T
R
L
E
D
D
E
T
L
L
V
Q
S
G
K
P
V
G
V
F
K
T
H
S
N
A
P
R
V
L
I
A
N
S
N
L
V
P
H
W
A
N
W
E
H
F
N
E
L
D
A
K
G
L
A
M
Y
G
Q
M
T
A
G
S
W
I
Y
I
G
S
Q
G
I
V
Q
G
T
Y
E
T
F
V
E
A
G
R
Q
H
Y
G
G
S
L
K
G
K
W
V
L
T
A
G
L
G
G
M
G
G
A
Q
P
L
A
A
T
L
A
G
A
C
S
L
N
I
E
S
Q
Q
S
R
I
D
F
R
L
E
T
R
Y
V
D
E
Q
A
T
D
L
D
D
A
L
V
R
I
A
K
Y
T
A
E
G
K
A
I
S
I
A
L
H
G
N
A
A
E
I
L
P
E
L
V
K
R
G
V
R
P
D
M
V
T
D
Q
T
S
A
H
D
P
L
N
G
Y
L
P
A
G
W
T
W
E
Q
Y
R
D
R
A
Q
T
E
P
A
A
V
V
K
A
A
K
Q
S
M
A
V
H
V
Q
A
M
L
D
F
Q
K
Q
G
V
P
T
F
D
Y
G
N
N
I
R
Q
M
A
K
E
E
G
V
A
D
A
F
D
F
P
G
F
V
P
A
Y
I
R
P
L
F
C
R
G
V
G
P
F
R
W
A
A
L
S
G
E
A
E
D
I
Y
K
T
D
A
K
V
K
E
L
I
P
D
D
A
H
L
H
R
W
L
D
M
A
R
E
R
I
S
F
Q
G
L
P
A
R
I
C
W
V
G
L
G
L
R
A
K
L
G
L
A
F
N
E
M
V
R
S
G
E
L
S
A
P
V
V
I
G
R
D
H
L
D
S
G
S
V
S
S
P
N
A
E
T
E
A
M
R
D
G
S
D
A
V
S
D
W
P
L
L
N
A
L
L
N
T
A
G
G
A
T
W
V
S
L
H
H
G
G
G
V
G
M
G
F
S
Q
H
S
G
M
V
I
V
C
D
G
T
D
E
A
A
E
R
I
A
R
V
L
T
N
D
P
G
T
G
V
M
R
H
A
D
A
G
Y
D
I
A
I
D
C
A
K
E
Q
G
L
D
L
P
M
I
T
G
14
PsiBlast_CBE
75.11
63%
10
- C4 -
2V7G
8
HUTU_PSEPU
D:
[5-554]
-----
N
K
YRDV
E
I
R
A
P
R
G
N
K
L
T
A
K
S
W
L
T
E
A
P
L
R
M
L
M
N
N
L
D
P
Q
V
A
E
N
P
K
E
L
V
V
Y
G
G
I
G
R
A
A
R
N
W
E
C
Y
D
K
I
V
E
T
L
T
R
L
E
D
D
E
T
L
L
V
Q
S
G
K
P
V
G
V
F
K
T
H
S
N
A
P
R
V
L
I
A
N
S
N
L
V
P
H
W
A
N
W
E
H
F
N
E
L
D
A
K
G
L
A
M
Y
G
Q
M
T
A
G
S
W
I
Y
I
G
S
Q
G
I
V
Q
G
T
Y
E
T
F
V
E
A
G
R
Q
H
Y
G
G
S
L
K
G
K
W
V
L
T
A
G
L
G
G
M
G
G
A
Q
P
L
A
A
T
L
A
G
A
C
S
L
N
I
E
S
Q
Q
S
R
I
D
F
R
L
E
T
R
Y
V
D
E
Q
A
T
D
L
D
D
A
L
V
R
I
A
K
Y
T
A
E
G
K
A
I
S
I
A
L
H
G
N
A
A
E
I
L
P
E
L
V
K
R
G
V
R
P
D
M
V
T
D
Q
T
S
A
H
D
P
L
N
G
Y
L
P
I
G
W
T
W
E
Q
Y
R
D
R
A
Q
T
I
P
A
A
V
V
K
A
A
K
A
S
M
A
V
H
V
Q
A
M
L
D
F
Q
K
Q
G
V
P
T
F
D
Y
G
N
N
I
R
Q
M
A
K
E
E
G
V
A
N
A
F
D
F
P
G
F
V
P
A
Y
I
R
P
L
F
C
R
G
V
G
P
F
R
W
A
A
L
S
G
E
A
E
D
I
Y
K
T
D
A
K
V
K
E
L
I
P
D
D
A
H
L
H
R
W
L
D
M
A
R
E
R
I
S
F
Q
G
L
P
A
R
I
C
W
V
G
L
G
L
R
A
K
L
G
L
A
F
N
E
M
V
R
S
G
E
L
S
A
P
V
V
I
G
R
D
H
L
D
S
G
S
V
S
S
P
N
R
E
T
E
A
M
R
D
G
S
D
A
V
S
D
W
P
L
L
N
A
L
L
N
T
A
G
G
A
T
W
V
S
L
H
H
G
G
G
V
G
M
G
F
S
Q
H
S
G
M
V
I
V
C
D
G
T
D
E
A
A
E
R
I
A
R
V
L
T
N
D
P
G
T
G
V
M
R
H
A
D
A
G
Y
D
I
A
I
D
C
A
K
E
Q
G
L
D
L
P
M
---
5
PsiBlast_PDB
74.69
63%
16
- C4 -
2V7G
5
HUTU_PSEPU
A:
[5-554]
-----
N
K
YRD
V
E
I
R
A
P
R
G
N
K
L
T
A
K
S
W
L
T
E
A
P
L
R
M
L
M
N
N
L
D
P
Q
V
A
E
N
P
K
E
L
V
V
Y
G
G
I
G
R
A
A
R
N
W
E
C
Y
D
K
I
V
E
T
L
T
R
L
E
D
D
E
T
L
L
V
Q
S
G
K
P
V
G
V
F
K
T
H
S
N
A
P
R
V
L
I
A
N
S
N
L
V
P
H
W
A
N
W
E
H
F
N
E
L
D
A
K
G
L
A
M
Y
G
Q
M
T
A
G
S
W
I
Y
I
G
S
Q
G
I
V
Q
G
T
Y
E
T
F
V
E
A
G
R
Q
H
Y
G
G
S
L
K
G
K
W
V
L
T
A
G
L
G
G
M
G
G
A
Q
P
L
A
A
T
L
A
G
A
C
S
L
N
I
E
S
Q
Q
S
R
I
D
F
R
L
E
T
R
Y
V
D
E
Q
A
T
D
L
D
D
A
L
V
R
I
A
K
Y
T
A
E
G
K
A
I
S
I
A
L
H
G
N
A
A
E
I
L
P
E
L
V
K
R
G
V
R
P
D
M
V
T
D
Q
T
S
A
H
D
P
L
N
G
Y
L
P
I
G
W
T
W
E
Q
Y
R
D
R
A
Q
T
I
P
A
A
V
V
K
A
A
K
A
S
M
A
V
H
V
Q
A
M
L
D
F
Q
K
Q
G
V
P
T
F
D
Y
G
N
N
I
R
Q
M
A
K
E
E
G
V
A
N
A
F
D
F
P
G
F
V
P
A
Y
I
R
P
L
F
C
R
G
V
G
P
F
R
W
A
A
L
S
G
E
A
E
D
I
Y
K
T
D
A
K
V
K
E
L
I
P
D
D
A
H
L
H
R
W
L
D
M
A
R
E
R
I
S
F
Q
G
L
P
A
R
I
C
W
V
G
L
G
L
R
A
K
L
G
L
A
F
N
E
M
V
R
S
G
E
L
S
A
P
V
V
I
G
R
D
H
L
D
S
G
S
V
S
S
P
N
R
E
T
E
A
M
R
D
G
S
D
A
V
S
D
W
P
L
L
N
A
L
L
N
T
A
G
G
A
T
W
V
S
L
H
H
G
G
G
V
G
M
G
F
S
Q
H
S
G
M
V
I
V
C
D
G
T
D
E
A
A
E
R
I
A
R
V
L
T
N
D
P
G
T
G
V
M
R
H
A
D
A
G
Y
D
I
A
I
D
C
A
K
E
Q
G
L
D
L
P
M
---
16
PsiBlast_CBE
74.67
63%
15
- C4 -
2V7G
7
HUTU_PSEPU
B:
[5-554]
-----
N
K
YRDV
E
I
R
A
P
R
G
N
K
L
T
A
K
S
W
L
T
E
A
P
L
R
M
L
M
N
N
L
D
P
Q
V
A
E
N
P
K
E
L
V
V
Y
G
G
I
G
R
A
A
R
N
W
E
C
Y
D
K
I
V
E
T
L
T
R
L
E
D
D
E
T
L
L
V
Q
S
G
K
P
V
G
V
F
K
T
H
S
N
A
P
R
V
L
I
A
N
S
N
L
V
P
H
W
A
N
W
E
H
F
N
E
L
D
A
K
G
L
A
M
Y
G
Q
M
T
A
G
S
W
I
Y
I
G
S
Q
G
I
V
Q
G
T
Y
E
T
F
V
E
A
G
R
Q
H
Y
G
G
S
L
K
G
K
W
V
L
T
A
G
L
G
G
M
G
G
A
Q
P
L
A
A
T
L
A
G
A
C
S
L
N
I
E
S
Q
Q
S
R
I
D
F
R
L
E
T
R
Y
V
D
E
Q
A
T
D
L
D
D
A
L
V
R
I
A
K
Y
T
A
E
G
K
A
I
S
I
A
L
H
G
N
A
A
E
I
L
P
E
L
V
K
R
G
V
R
P
D
M
V
T
D
Q
T
S
A
H
D
P
L
N
G
Y
L
P
I
G
W
T
W
E
Q
Y
R
D
R
A
Q
T
I
P
A
A
V
V
K
A
A
K
A
S
M
A
V
H
V
Q
A
M
L
D
F
Q
K
Q
G
V
P
T
F
D
Y
G
N
N
I
R
Q
M
A
K
E
E
G
V
A
N
A
F
D
F
P
G
F
V
P
A
Y
I
R
P
L
F
C
R
G
V
G
P
F
R
W
A
A
L
S
G
E
A
E
D
I
Y
K
T
D
A
K
V
K
E
L
I
P
D
D
A
H
L
H
R
W
L
D
M
A
R
E
R
I
S
F
Q
G
L
P
A
R
I
C
W
V
G
L
G
L
R
A
K
L
G
L
A
F
N
E
M
V
R
S
G
E
L
S
A
P
V
V
I
G
R
D
H
L
D
S
G
S
V
S
S
P
N
R
E
T
E
A
M
R
D
G
S
D
A
V
S
D
W
P
L
L
N
A
L
L
N
T
A
G
G
A
T
W
V
S
L
H
H
G
G
G
V
G
M
G
F
S
Q
H
S
G
M
V
I
V
C
D
G
T
D
E
A
A
E
R
I
A
R
V
L
T
N
D
P
G
T
G
V
M
R
H
A
D
A
G
Y
D
I
A
I
D
C
A
K
E
Q
G
L
D
L
P
M
---
15
PsiBlast_CBE
74.44
63%
11
- C4 -
2V7G
3
HUTU_PSEPU
C:
[5-554]
-----
N
K
YRDV
E
I
R
A
P
R
G
N
K
L
T
A
K
S
W
L
T
E
A
P
L
R
M
L
M
N
N
L
D
P
Q
V
A
E
N
P
K
E
L
V
V
Y
G
G
I
G
R
A
A
R
N
W
E
C
Y
D
K
I
V
E
T
L
T
R
L
E
D
D
E
T
L
L
V
Q
S
G
K
P
V
G
V
F
K
T
H
S
N
A
P
R
V
L
I
A
N
S
N
L
V
P
H
W
A
N
W
E
H
F
N
E
L
D
A
K
G
L
A
M
Y
G
Q
M
T
A
G
S
W
I
Y
I
G
S
Q
G
I
V
Q
G
T
Y
E
T
F
V
E
A
G
R
Q
H
Y
G
G
S
L
K
G
K
W
V
L
T
A
G
L
G
G
M
G
G
A
Q
P
L
A
A
T
L
A
G
A
C
S
L
N
I
E
S
Q
Q
S
R
I
D
F
R
L
E
T
R
Y
V
D
E
Q
A
T
D
L
D
D
A
L
V
R
I
A
K
Y
T
A
E
G
K
A
I
S
I
A
L
H
G
N
A
A
E
I
L
P
E
L
V
K
R
G
V
R
P
D
M
V
T
D
Q
T
S
A
H
D
P
L
N
G
Y
L
P
I
G
W
T
W
E
Q
Y
R
D
R
A
Q
T
I
P
A
A
V
V
K
A
A
K
A
S
M
A
V
H
V
Q
A
M
L
D
F
Q
K
Q
G
V
P
T
F
D
Y
G
N
N
I
R
Q
M
A
K
E
E
G
V
A
N
A
F
D
F
P
G
F
V
P
A
Y
I
R
P
L
F
C
R
G
V
G
P
F
R
W
A
A
L
S
G
E
A
E
D
I
Y
K
T
D
A
K
V
K
E
L
I
P
D
D
A
H
L
H
R
W
L
D
M
A
R
E
R
I
S
F
Q
G
L
P
A
R
I
C
W
V
G
L
G
L
R
A
K
L
G
L
A
F
N
E
M
V
R
S
G
E
L
S
A
P
V
V
I
G
R
D
H
L
D
S
G
S
V
S
S
P
N
R
E
T
E
A
M
R
D
G
S
D
A
V
S
D
W
P
L
L
N
A
L
L
N
T
A
G
G
A
T
W
V
S
L
H
H
G
G
G
V
G
M
G
F
S
Q
H
S
G
M
V
I
V
C
D
G
T
D
E
A
A
E
R
I
A
R
V
L
T
N
D
P
G
T
G
V
M
R
H
A
D
A
G
Y
D
I
A
I
D
C
A
K
E
Q
G
L
D
L
P
M
---
13
PsiBlast_CBE
74.29
63%
16
- C4 -
1UWK
2
HUTU_PSEPU
B:
[5-554]
-----
N
K
YRD
V
E
I
R
A
P
R
G
N
K
L
T
A
K
S
W
L
T
E
A
P
L
R
M
L
M
N
N
L
D
P
Q
V
A
E
N
P
K
E
L
V
V
Y
G
G
I
G
R
A
A
R
N
W
E
C
Y
D
K
I
V
E
T
L
T
R
L
E
D
D
E
T
L
L
V
Q
S
G
K
P
V
G
V
F
K
T
H
S
N
A
P
R
V
L
I
A
N
S
N
L
V
P
H
W
A
N
W
E
H
F
N
E
L
D
A
K
G
L
A
M
Y
G
Q
M
T
A
G
S
W
I
Y
I
G
S
Q
G
I
V
Q
G
T
Y
E
T
F
V
E
A
G
R
Q
H
Y
G
G
S
L
K
G
K
W
V
L
T
A
G
L
G
G
M
G
G
A
Q
P
L
A
A
T
L
A
G
A
C
S
L
N
I
E
S
Q
Q
S
R
I
D
F
R
L
E
T
R
Y
V
D
E
Q
A
T
D
L
D
D
A
L
V
R
I
A
K
Y
T
A
E
G
K
A
I
S
I
A
L
H
G
N
A
A
E
I
L
P
E
L
V
K
R
G
V
R
P
D
M
V
T
D
Q
T
S
A
H
D
P
L
N
G
Y
L
P
A
G
W
T
W
E
Q
Y
R
D
R
A
Q
T
E
P
A
A
V
V
K
A
A
K
Q
S
M
A
V
H
V
Q
A
M
L
D
F
Q
K
Q
G
V
P
T
F
D
Y
G
N
N
I
R
Q
M
A
K
E
E
G
V
A
D
A
F
D
F
P
G
F
V
P
A
Y
I
R
P
L
F
C
R
G
V
G
P
F
R
W
A
A
L
S
G
E
A
E
D
I
Y
K
T
D
A
K
V
K
E
L
I
P
D
D
A
H
L
H
R
W
L
D
M
A
R
E
R
I
S
F
Q
G
L
P
A
R
I
C
W
V
G
L
G
L
R
A
K
L
G
L
A
F
N
E
M
V
R
S
G
E
L
S
A
P
V
V
I
G
R
D
H
L
D
S
G
S
V
S
S
P
N
A
E
T
E
A
M
R
D
G
S
D
A
V
S
D
W
P
L
L
N
A
L
L
N
T
A
G
G
A
T
W
V
S
L
H
H
G
G
G
V
G
M
G
F
S
Q
H
S
G
M
V
I
V
C
D
G
T
D
E
A
A
E
R
I
A
R
V
L
T
N
D
P
G
T
G
V
M
R
H
A
D
A
G
Y
D
I
A
I
D
C
A
K
E
Q
G
L
D
L
P
M
---
4
PsiBlast_PDB
73.92
63%
16
- C4 -
1UWK
2
HUTU_PSEPU
A:
[4-554]
----
N
N
K
YRD
V
E
I
R
A
P
R
G
N
K
L
T
A
K
S
W
L
T
E
A
P
L
R
M
L
M
N
N
L
D
P
Q
V
A
E
N
P
K
E
L
V
V
Y
G
G
I
G
R
A
A
R
N
W
E
C
Y
D
K
I
V
E
T
L
T
R
L
E
D
D
E
T
L
L
V
Q
S
G
K
P
V
G
V
F
K
T
H
S
N
A
P
R
V
L
I
A
N
S
N
L
V
P
H
W
A
N
W
E
H
F
N
E
L
D
A
K
G
L
A
M
Y
G
Q
M
T
A
G
S
W
I
Y
I
G
S
Q
G
I
V
Q
G
T
Y
E
T
F
V
E
A
G
R
Q
H
Y
G
G
S
L
K
G
K
W
V
L
T
A
G
L
G
G
M
G
G
A
Q
P
L
A
A
T
L
A
G
A
C
S
L
N
I
E
S
Q
Q
S
R
I
D
F
R
L
E
T
R
Y
V
D
E
Q
A
T
D
L
D
D
A
L
V
R
I
A
K
Y
T
A
E
G
K
A
I
S
I
A
L
H
G
N
A
A
E
I
L
P
E
L
V
K
R
G
V
R
P
D
M
V
T
D
Q
T
S
A
H
D
P
L
N
G
Y
L
P
A
G
W
T
W
E
Q
Y
R
D
R
A
Q
T
E
P
A
A
V
V
K
A
A
K
Q
S
M
A
V
H
V
Q
A
M
L
D
F
Q
K
Q
G
V
P
T
F
D
Y
G
N
N
I
R
Q
M
A
K
E
E
G
V
A
D
A
F
D
F
P
G
F
V
P
A
Y
I
R
P
L
F
C
R
G
V
G
P
F
R
W
A
A
L
S
G
E
A
E
D
I
Y
K
T
D
A
K
V
K
E
L
I
P
D
D
A
H
L
H
R
W
L
D
M
A
R
E
R
I
S
F
Q
G
L
P
A
R
I
C
W
V
G
L
G
L
R
A
K
L
G
L
A
F
N
E
M
V
R
S
G
E
L
S
A
P
V
V
I
G
R
D
H
L
D
S
G
S
V
S
S
P
N
A
E
T
E
A
M
R
D
G
S
D
A
V
S
D
W
P
L
L
N
A
L
L
N
T
A
G
G
A
T
W
V
S
L
H
H
G
G
G
V
G
M
G
F
S
Q
H
S
G
M
V
I
V
C
D
G
T
D
E
A
A
E
R
I
A
R
V
L
T
N
D
P
G
T
G
V
M
R
H
A
D
A
G
Y
D
I
A
I
D
C
A
K
E
Q
G
L
D
L
P
M
---
22
HHSearch
35.85
16%
-91
- C4 -
3D64
1
SAHH_BURP1
A:
[259-320]
-----------------------------------------------------------------------------------------------------------------------------------------------------
C
R
E
S
L
V
D
G
I
K
R
A
T
D
V
M
I
A
G
K
I
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
Q
S
L
R
G
L
G
A
T
V
W
V
T
E
I
D
P
I
C
A
L
Q
A
A
M
E
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
34.95
13%
-101
- C4 -
3GVP
1
SAHH3_HUMAN
A:
[204-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
I
L
D
G
L
K
R
T
T
D
M
M
F
G
G
K
Q
V
V
V
C
G
Y
G
E
V
G
K
G
C
C
A
A
L
K
A
M
G
S
I
V
Y
V
T
E
I
D
P
I
C
A
L
Q
A
C
M
D
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
34.47
15%
-111
- C4 -
1V8B
1
SAHH_PLAF7
A:
[237-296]
---------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
C
R
H
S
L
P
D
G
L
M
R
A
T
D
F
L
I
S
G
K
I
V
V
I
C
G
Y
G
D
V
G
K
G
C
A
S
S
M
K
G
L
G
A
R
V
Y
I
T
E
I
D
P
I
C
A
I
Q
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------