@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu39520: (2016-08-05 )
MTSKKKQIKLGVFLAGTGHHVASWRHPDAPSDASMNLDYFKELAKTAERGKLDMLFLADSLSIDSKSHPNVLTRFEPFTLLSALAQVTSKIGLTATASTTYSEPFHIARQFASLDHLSNGRAGWNVVTSSIESTALNFSGEKHLEHHLRYQRAEEFVEIVKGLWDSWEEDAFIRNKETGEFFDKEKMHELNHKGEYFSVRGPLNVSRTPQGQPVIIQAGSSGDGKALAAKTAEVIFTAQNHLESAQEFYQSIKEQAAEFGRDPEKIAIMPGIFPIIADTEEAAQAKYKELQDLIIPSVGLQILQNYLGGIDLSAYPLDGPLPKLDAEASNAVKSRFKLVQEMAERDNMTIRELYKYVAGSRGHHIFVGTPEQLADKMQEWVDTKACDGFNIMPPLLPEGIEVFVDQVVPILQERGVFRKEYEGTTLREHFGLEKPVNRYAK
Atome Classification :
(20 SA)
.........10........20..--......30........40........50........60-...--------......---------70-........80........90.....-.-..100........110.......120.......130--.......140.-......150.......160...-.-...170.......180..-.....190.......200-.---------......210........220--........230.......240.....-...250.......260.......270.......280.......290.....-.-..300.......310.........320.......330..---.....340.---.---.....350.---..--.-.---..360.----......370.......380..-.....390..---.------.-----...400.......410.......420.......430.......440
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTSK
K
K
Q
I
K
L
G
V
F
L
AGTGHHVAS--WRHPDAPSDASM
N
L
D
Y
F
K
E
L
A
K
T
A
ERGK
L
D
M
L
F
L
ADS--LSI--------DSKSHP---------
N
V
-
L
TRF
E
P
F
T
L
L
S
A
L
A
Q
V
T
S
KIG
L
T
A
T-A-STT-YS
E
P
F
H
I
A
R
Q
F
A
S
L
D
HLSNGRAG
W
N
V
V
T
SS
I
E
--
S
T
ALNFS
G
E
K
H
-
L
E
H
H
L
R
Y
Q
R
A
E
E
F
V
E
I
V
K
G
L
W
D-S-WEEDAFIRNKETGEFF
D
K
-
E
K
M
H
ELNHKG
E
Y
F
S
VRGP-L---------NVSRTPQ-G
Q
P
V
I
I
QAGS-S--GDG
K
A
LAA
K
T
A
E
V
I
F
T
A
Q
N
-
H
L
E
S
A
Q
-
E
F
Y
Q
S
I
K
E
Q
A
A
E
FGRDP
E
K
I
A
IMPGIFPIIAD
T
E
E
A
A
Q
A
K
Y
K
E
L
-
Q
D
L
II
P
-
S
-
V
G
L
Q
I
L
Q
N
Y
LG
G
I
--DLSAYPLDGPLPKLD
A
E
A
S
N
A
V
K
S
---
R
F
K
L
V
Q
E
M
A
---
E
---RDN
M
T
I
R
E
L
---
Y
K
--
Y
-
V
---AGSRG
H
----
H
I
F
VG
T
P
E
Q
L
A
D
K
M
Q
E
W
V
DTK-ACDGFNIMPP---L------L-----
P
E
G
I
E
V
F
V
D
Q
V
V
P
I
L
Q
ERGVFRKEYEG
T
T
L
R
E
HFGL
E
K
P
V
N
R
YAK
3
PsiBlast_PDB
97.68
45%
-76
- C3 -
3SDO
2
?
A:
[7-445]
----
R
K
H
I
H
F
G
V
L
I
Q
G
A
G
A
N
M
N
A
--
W
K
H
P
S
V
P
P
D
A
S
V
N
F
D
F
Y
V
D
R
A
R
R
A
E
N
A
G
I
A
F
A
F
I
A
D
S
--
A
Y
V
--------
T
P
K
S
A
P
---------
H
F
-
L
N
R
F
E
P
I
S
L
L
S
A
L
A
V
L
T
S
K
I
G
L
V
G
T
-
M
-
S
S
S
-
Y
S
E
P
Y
N
V
A
R
Q
F
A
S
L
D
L
I
S
G
G
R
A
G
W
N
V
V
T
S
S
I
E
--
G
T
G
K
N
Y
-
G
R
P
H
-
P
D
H
A
Q
R
Y
A
I
A
A
E
H
L
D
V
V
Q
G
L
W
D
-
S
-
W
D
D
D
A
L
V
R
D
R
A
T
G
R
F
F
D
P
-
D
K
L
H
R
L
D
H
R
G
R
F
F
S
V
E
G
P
-
L
---------
N
I
R
R
S
P
Q
-
G
Q
P
V
I
F
Q
A
G
S
-
S
--
D
D
G
I
D
L
A
G
R
S
A
D
A
V
F
S
N
G
S
-
T
F
D
E
A
R
-
V
F
Y
R
R
V
K
A
A
A
A
A
A
G
R
N
P
D
H
V
K
V
F
P
G
I
G
P
I
V
G
A
T
Q
Q
E
A
D
D
K
Y
R
Q
V
-
R
D
L
L
S
P
-
R
-
E
A
L
A
Y
L
S
H
F
F
Q
Q
H
--
D
F
S
V
Y
P
L
D
G
P
F
P
D
I
G
T
L
G
S
D
G
F
Q
S
---
T
T
D
N
I
K
R
L
A
---
R
---
E
R
K
L
T
L
R
E
V
---
A
Y
--
E
-
V
---
S
T
R
R
S
N
IGTS
E
A
F
I
G
T
P
E
A
V
A
S
E
M
I
R
W
V
D
E
G
-
A
A
D
G
F
M
L
G
L
P
---
V
------
T
-----
G
F
G
L
D
D
F
V
D
H
V
L
P
V
L
S
A
R
G
Y
F
D
P
V
R
R
G
A
T
L
R
D
H
L
G
L
P
Y
K
E
S
R
Y
A
-
2
PsiBlast_PDB
96.51
48%
-85
- C3 -
1YW1
2
MOXC_BACSU
A:
[7-431]
-------
I
Q
F
G
A
M
I
H
G
V
G
G
T
T
D
G
--
W
R
H
P
D
V
D
P
S
A
S
T
N
I
E
F
Y
M
K
K
A
Q
T
A
E
K
G
L
F
S
F
I
F
I
A
D
G
--
L
F
I
--------
S
E
K
S
I
P
---------
H
F
-
L
N
R
F
E
P
I
T
I
L
S
A
L
A
S
V
T
K
N
I
G
L
V
G
T
-
F
-
S
T
S
-
F
T
E
P
F
T
I
S
R
Q
L
M
S
L
D
H
I
S
G
G
R
A
G
W
N
L
V
T
S
P
Q
E
--
G
A
A
R
N
H
S
K
S
N
L
-
P
E
H
T
E
R
Y
E
I
A
Q
E
H
L
D
V
V
R
G
L
W
N
-
S
-
W
E
H
D
A
F
I
H
N
K
K
T
G
Q
F
F
D
Q
-
A
K
L
H
R
L
N
H
K
G
K
Y
F
Q
V
E
G
P
-
L
---------
N
I
G
R
S
K
Q
-
G
E
P
V
V
F
Q
A
G
S
-
S
--
E
T
G
R
Q
F
A
A
K
N
A
D
A
I
F
T
H
S
N
-
S
L
E
E
T
K
-
A
F
Y
A
D
V
K
S
R
A
A
D
E
G
R
D
P
S
S
V
R
I
F
P
G
I
S
P
I
V
A
D
T
E
E
E
A
E
K
K
Y
R
E
F
-
A
E
L
I
P
I
-
E
-
N
A
V
T
Y
L
A
-----------------------------------------
R
E
A
---
K
---
A
R
N
L
T
L
R
E
V
---
A
Q
--
E
-
M
---
A
F
P
R
T
------
L
F
I
G
T
P
E
R
V
A
S
L
I
E
T
W
F
N
A
E
-
A
A
D
G
F
-
I
V
G
S
---
D
------
I
-----
P
G
T
L
D
A
F
V
E
K
V
I
P
I
L
Q
E
R
G
L
Y
R
Q
D
Y
R
G
G
T
L
R
E
N
L
G
L
G
I
P
------
1
PsiBlast_PDB
95.95
48%
-82
- C3 -
1TVL
-
MOXC_BACSU
A:
[7-431]
-------
I
Q
F
G
A
M
I
H
G
V
G
G
T
T
D
G
--
W
R
H
P
D
V
D
P
S
A
S
T
N
I
E
F
Y
M
K
K
A
Q
T
A
E
K
G
L
F
S
F
I
F
I
A
D
G
--
L
F
I
--------
S
E
K
S
I
P
---------
H
F
-
L
N
R
F
E
P
I
T
I
L
S
A
L
A
S
V
T
K
N
I
G
L
V
G
T
-
F
-
S
T
S
-
F
T
E
P
F
T
I
S
R
Q
L
M
S
L
D
H
I
S
G
G
R
A
G
W
N
L
V
T
S
P
Q
E
--
G
A
A
R
N
H
S
K
S
N
L
-
P
E
H
T
E
R
Y
E
I
A
Q
E
H
L
D
V
V
R
G
L
W
N
-
S
-
W
E
H
D
A
F
I
H
N
K
K
T
G
Q
F
F
D
Q
-
A
K
L
H
R
L
N
H
K
G
K
Y
F
Q
V
E
G
P
-
L
---------
N
I
G
R
S
K
Q
-
G
E
P
V
V
F
Q
A
G
S
-
S
--
E
T
G
R
Q
F
A
A
K
N
A
D
A
I
F
T
H
S
N
-
S
L
E
E
T
K
-
A
F
Y
A
D
V
K
S
R
A
A
D
E
G
R
D
P
S
S
V
R
I
F
P
G
I
S
P
I
V
A
D
T
E
E
E
A
E
K
K
Y
R
E
F
-
A
E
L
I
P
I
-
E
-
N
A
V
T
---------------------------------------------
E
A
---
K
---
A
R
N
L
T
L
R
E
V
---
A
Q
--
E
-
M
---
A
F
P
R
------
T
L
F
I
G
T
P
E
R
V
A
S
L
I
E
T
W
F
N
A
E
-
A
A
D
G
F
-
I
V
G
S
---
D
------
I
-----
P
G
T
L
D
A
F
V
E
K
V
I
P
I
L
Q
E
R
G
L
Y
R
Q
D
Y
R
G
G
T
L
R
E
N
L
G
L
G
I
P
------
16
HHSearch
95.53
47%
-78
- C3 -
1TVL
-
MOXC_BACSU
A:
[3-432]
---
R
A
D
F
I
Q
F
G
A
M
I
H
G
V
G
G
T
T
D
G
--
W
R
H
P
D
V
D
P
S
A
S
T
N
I
E
F
Y
M
K
K
A
Q
T
A
E
K
G
L
F
S
F
I
F
I
A
D
G
--
L
F
I
--------
S
E
K
S
I
P
---------
H
F
-
L
N
R
F
E
P
I
T
I
L
S
A
L
A
S
V
T
K
N
I
G
L
V
G
T
-
F
-
S
T
S
-
F
T
E
P
F
T
I
S
R
Q
L
M
S
L
D
H
I
S
G
G
R
A
G
W
N
L
V
T
S
P
Q
E
--
G
A
A
R
N
H
S
K
S
N
L
-
P
E
H
T
E
R
Y
E
I
A
Q
E
H
L
D
V
V
R
G
L
W
N
-
S
-
W
E
H
D
A
F
I
H
N
K
K
T
G
Q
F
F
D
Q
-
A
K
L
H
R
L
N
H
K
G
K
Y
F
Q
V
E
G
P
-
L
---------
N
I
G
R
S
K
Q
-
G
E
P
V
V
F
Q
A
G
S
-
S
--
E
T
G
R
Q
F
A
A
K
N
A
D
A
I
F
T
H
S
N
-
S
L
E
E
T
K
-
A
F
Y
A
D
V
K
S
R
A
A
D
E
G
R
D
P
S
S
V
R
I
F
P
G
I
S
P
I
V
A
D
T
E
E
E
A
E
K
K
Y
R
E
F
-
A
E
L
I
P
I
-
E
-
N
A
V
T
---------------------------------------------
E
A
---
K
---
A
R
N
L
T
L
R
E
V
---
A
Q
--
E
-
M
---
A
--
F
P
R
----
T
L
F
I
G
T
P
E
R
V
A
S
L
I
E
T
W
F
N
A
E
-
A
A
D
G
F
I
V
G
S
----
D
------
I
-----
P
G
T
L
D
A
F
V
E
K
V
I
P
I
L
Q
E
R
G
L
Y
R
Q
D
Y
R
G
G
T
L
R
E
N
L
G
L
G
I
P
Q
-----
34
Fugue
95.46
49%
-75
- C3 -
1TVL
-
MOXC_BACSU
A:
[3-432]
---
R
A
D
F
I
Q
F
G
A
M
I
H
G
V
G
G
T
T
D
G
--
W
R
H
P
D
V
D
P
S
A
S
T
N
I
E
F
Y
M
K
K
A
Q
T
A
E
K
G
L
F
S
F
I
F
I
A
D
G
--
L
F
I
--------
S
E
K
S
I
P
---------
H
F
-
L
N
R
F
E
P
I
T
I
L
S
A
L
A
S
V
T
K
N
I
G
L
V
G
T
-
F
-
S
T
S
-
F
T
E
P
F
T
I
S
R
Q
L
M
S
L
D
H
I
S
G
G
R
A
G
W
N
L
V
T
S
P
Q
E
--
G
A
A
R
N
H
S
K
S
N
L
-
P
E
H
T
E
R
Y
E
I
A
Q
E
H
L
D
V
V
R
G
L
W
N
-
S
-
W
E
H
D
A
F
I
H
N
K
K
T
G
Q
F
F
D
Q
-
A
K
L
H
R
L
N
H
K
G
K
Y
F
Q
V
E
G
P
-
L
---------
N
I
G
R
S
K
Q
-
G
E
P
V
V
F
Q
A
G
S
-
S
--
E
T
G
R
Q
F
A
A
K
N
A
D
A
I
F
T
H
S
N
-
S
L
E
E
T
K
-
A
F
Y
A
D
V
K
S
R
A
A
D
E
G
R
D
P
S
S
V
R
I
F
P
G
I
S
P
I
V
A
D
T
E
E
E
A
E
K
K
Y
R
E
F
-
A
E
L
I
P
I
-
E
-
N
A
V
T
---------------------------------------------
E
A
---
K
---
A
R
N
L
T
L
R
E
V
---
A
Q
--
E
-
M
---
A
F
P
R
T
L
------
F
I
G
T
P
E
R
V
A
S
L
I
E
T
W
F
N
A
E
-
A
A
D
G
F
I
V
G
S
D
---
I
------------
P
G
T
L
D
A
F
V
E
K
V
I
P
I
L
Q
E
R
G
L
Y
R
Q
D
Y
R
G
G
T
L
R
E
N
L
G
L
G
I
P
Q
-----
15
HHSearch
87.85
44%
-16
- C3 -
3SDO
2
?
A:
[4-445]
-
S
M
T
R
K
H
I
H
F
G
V
L
I
Q
G
A
G
A
N
M
N
A
--
W
K
H
P
S
V
P
P
D
A
S
V
N
F
D
F
Y
V
D
R
A
R
R
A
E
N
A
G
I
A
F
A
F
I
A
D
S
--
A
Y
V
--------
T
P
K
S
A
P
---------
H
F
-
L
N
R
F
E
P
I
S
L
L
S
A
L
A
V
L
T
S
K
I
G
L
V
G
T
-
M
-
S
S
S
-
Y
S
E
P
Y
N
V
A
R
Q
F
A
S
L
D
L
I
S
G
G
R
A
G
W
N
V
V
T
S
S
I
E
--
G
T
G
K
N
Y
G
R
P
H
--
P
D
H
A
Q
R
Y
A
I
A
A
E
H
L
D
V
V
Q
G
L
W
D
-
S
-
W
D
D
D
A
L
V
R
D
R
A
T
G
R
F
F
D
P
-
D
K
L
H
R
L
D
H
R
G
R
F
F
S
V
E
G
P
L
N
---------
I
R
R
S
P
-
Q
-
G
Q
P
V
I
F
Q
A
G
S
-
S
--
D
D
G
I
D
L
A
G
R
S
A
D
A
V
F
S
N
G
S
-
T
F
D
E
A
R
-
V
F
Y
R
R
V
K
A
A
A
A
A
A
G
R
N
P
D
H
V
K
V
F
P
G
I
G
P
I
V
G
A
T
Q
Q
E
A
D
D
K
Y
R
Q
V
-
R
D
L
L
S
P
-
R
-
E
A
L
A
Y
L
S
H
F
F
Q
Q
H
--
D
F
S
V
Y
P
L
D
G
P
F
P
D
I
G
T
L
G
S
D
G
F
Q
S
---
T
T
D
N
I
K
R
L
A
---
R
---
E
R
K
L
T
L
R
E
V
A
Y
E
V
S
T
-
R
R
S
---
N
I
-
G
T
S
----
E
A
F
I
G
T
P
E
A
V
A
S
E
M
I
R
W
V
D
E
G
-
A
A
D
G
F
M
L
G
L
P
---
V
------
T
-----
G
F
G
L
D
D
F
V
D
H
V
L
P
V
L
S
A
R
G
Y
F
D
P
V
R
R
G
A
T
L
R
D
H
L
G
L
P
Y
K
E
S
R
Y
A
-
6
PsiBlast_PDB
79.47
34%
3
- C3 -
5DQP
2
?
A:
[4-426]
-----
R
R
M
Y
L
V
S
W
L
N
S
S
G
V
L
P
N
S
--
W
N
E
G
R
G
N
R
A
R
I
F
D
L
E
N
Y
I
R
S
A
E
I
A
R
R
G
R
I
D
A
F
F
L
A
D
Q
PQ
L
T
P
--------
N
P
K
V
R
P
---------
E
Y
---
P
F
D
P
I
V
L
A
A
A
I
T
G
R
V
P
D
I
G
G
I
V
T
-
A
-
S
T
S
-
F
S
L
P
Y
T
L
A
R
Q
I
A
S
V
N
L
L
S
G
G
R
I
G
W
N
A
V
T
T
A
N
P
--
A
V
A
A
N
Y
-
G
A
A
I
-
A
T
H
D
N
R
Y
E
R
A
E
E
F
L
E
V
V
H
G
L
W
N
-
S
-
W
K
---
F
P
W
D
E
A
I
G
P
N
P
N
P
F
G
E
V
M
P
I
N
H
E
G
K
Y
F
K
V
A
G
P
-
L
---------
N
V
P
L
P
P
Y
-
G
P
P
V
V
V
Q
A
G
G
-
S
--
D
Q
G
K
R
L
A
S
R
F
G
E
I
I
Y
A
F
L
G
-
S
K
P
A
G
R
-
R
F
V
A
E
A
R
A
A
A
R
A
Q
G
R
P
E
G
S
T
L
V
L
P
S
F
V
P
L
I
G
S
T
E
A
E
V
K
R
L
V
A
E
Y
-
E
A
G
L
D
P
-
A
E
Q
R
I
E
A
L
S
K
Q
L
G
-
I
--
D
L
E
R
I
N
V
D
Q
V
L
Q
E
K
D
F
N
L
P
K
E
S
A
T
---
P
I
G
I
L
K
S
M
V
---
D
V
A
L
D
E
K
L
S
L
R
Q
L
---------------
A
L
R
M
----
R
L
I
A
G
T
P
D
Q
V
A
D
R
L
I
D
W
W
Q
D
E
-
A
A
D
G
F
V
I
N
A
P
---
L
------
L
-----
P
D
A
L
E
I
F
V
D
Q
V
V
P
I
L
Q
S
R
G
V
F
P
R
S
Y
T
E
S
T
L
R
E
R
L
G
L
P
R
-------
18
HHSearch
79.10
34%
-11
- C3 -
5DQP
2
?
A:
[4-428]
-----
R
R
M
Y
L
V
S
W
L
N
S
S
G
V
L
P
N
S
--
W
N
E
G
R
G
N
R
A
R
I
F
D
L
E
N
Y
I
R
S
A
E
I
A
R
R
G
R
I
D
A
F
F
L
A
D
Q
--
P
Q
L
--------
T
P
N
P
K
V
---------
R
P
-
E
Y
P
F
D
P
I
V
L
A
A
A
I
T
G
R
V
P
D
I
G
-
G
I
V
T
A
-
S
T
S
-
F
S
L
P
Y
T
L
A
R
Q
I
A
S
V
N
L
L
S
G
G
R
I
G
W
N
A
V
T
T
A
N
P
--
A
V
A
A
N
Y
G
A
A
I
--
A
T
H
D
N
R
Y
E
R
A
E
E
F
L
E
V
V
H
G
L
W
N
-
S
-
W
---
K
F
P
W
D
E
A
I
G
P
N
P
N
P
F
G
E
V
M
P
I
N
H
E
G
K
Y
F
K
V
A
G
P
-
L
---------
N
V
P
L
P
P
Y
--
G
P
P
V
V
V
Q
A
G
G
S
--
D
Q
G
K
R
L
A
S
R
F
G
E
I
I
Y
A
F
L
G
-
S
K
P
A
G
R
-
R
F
V
A
E
A
R
A
A
A
R
A
Q
G
R
P
E
G
S
T
L
V
L
P
S
F
V
P
L
I
G
S
T
E
A
E
V
K
R
L
V
A
E
Y
-
E
A
G
L
D
P
A
E
-
Q
R
I
E
A
L
S
K
Q
L
G
-
I
--
D
L
E
R
I
N
V
D
Q
V
L
Q
E
--
K
D
F
-
N
L
P
K
E
SAT
P
I
G
I
L
K
S
M
V
D
V
A
L
---
D
E
K
L
S
L
R
Q
L
---
A
------------
L
R
M
----
R
L
I
A
G
T
P
D
Q
V
A
D
R
L
I
D
W
W
Q
D
E
-
A
A
D
G
F
V
I
N
A
P
---
L
------
L
-----
P
D
A
L
E
I
F
V
D
Q
V
V
P
I
L
Q
S
R
G
V
F
P
R
S
Y
T
E
S
T
L
R
E
R
L
G
L
P
R
N
P
-----
14
PsiBlast_CBE
72.12
35%
44
- C3 -
3B9O
1
?
B:
[3-414]
-----
K
K
I
H
I
N
A
F
E
M
N
C
V
G
H
I
A
H
GL
W
R
H
P
E
N
Q
R
H
R
Y
T
D
L
N
Y
W
T
E
L
A
Q
L
L
E
K
G
K
F
D
A
L
F
L
A
D
V
--
V
G
I
YDVYRQSR
D
T
A
V
R
E
---------
A
V
Q
I
P
V
N
D
P
L
M
L
I
S
A
M
A
Y
V
T
K
H
L
A
F
A
V
T
-
F
-
S
T
T
-
Y
E
H
P
Y
G
H
A
R
R
M
S
T
L
D
H
L
T
K
G
R
I
A
W
N
V
V
T
S
H
L
P
--
S
A
D
K
N
F
G
I
K
K
I
-
L
E
H
D
E
R
Y
D
L
A
D
E
Y
L
E
V
C
Y
K
L
W
E
G
S
-
W
E
D
N
A
V
I
R
D
I
E
N
N
I
Y
T
D
P
-
S
K
V
H
E
I
N
H
S
G
K
Y
F
E
V
P
G
P
-
H
---------
L
C
E
P
S
P
Q
-
R
T
P
V
I
Y
Q
A
G
M
-
S
--
E
R
G
R
E
F
A
A
K
H
A
E
C
V
F
L
G
G
K
-
D
V
E
T
L
K
-
F
F
V
D
D
I
R
K
R
A
K
K
Y
G
R
N
P
D
H
I
K
M
F
A
G
I
C
V
I
V
G
K
T
H
D
E
A
M
E
K
L
N
S
F
-
Q
K
Y
W
S
L
-
E
----
G
H
L
A
H
Y
G
G
G
T
GY
D
L
S
K
Y
S
S
N
D
Y
I
G
S
I
---------
S
---
V
G
E
I
I
N
N
M
S
---
K
---
L
D
G
K
W
F
K
--------------------------
L
S
V
G
T
P
K
K
V
A
D
E
M
Q
Y
L
V
E
E
A
-
G
I
D
G
F
N
L
V
Q
Y
---
V
------
S
-----
P
G
T
F
V
D
F
I
E
L
V
V
P
E
L
Q
K
R
G
L
Y
R
V
D
Y
E
E
G
T
Y
R
E
-------------
5
PsiBlast_PDB
72.07
35%
46
- C3 -
3B9O
1
?
A:
[3-414]
-----
K
K
I
H
I
N
A
F
E
M
N
C
V
G
H
I
A
H
GL
W
R
H
P
E
N
Q
R
H
R
Y
T
D
L
N
Y
W
T
E
L
A
Q
L
L
E
K
G
K
F
D
A
L
F
L
A
D
V
--
V
G
I
YDVYRQSR
D
T
A
V
R
E
---------
A
V
Q
I
P
V
N
D
P
L
M
L
I
S
A
M
A
Y
V
T
K
H
L
A
F
A
V
T
-
F
-
S
T
T
-
Y
E
H
P
Y
G
H
A
R
R
M
S
T
L
D
H
L
T
K
G
R
I
A
W
N
V
V
T
S
H
L
P
--
S
A
D
K
N
F
G
I
K
K
I
-
L
E
H
D
E
R
Y
D
L
A
D
E
Y
L
E
V
C
Y
K
L
W
E
G
S
-
W
E
D
N
A
V
I
R
D
I
E
N
N
I
Y
T
D
P
-
S
K
V
H
E
I
N
H
S
G
K
Y
F
E
V
P
G
P
-
H
---------
L
C
E
P
S
P
Q
-
R
T
P
V
I
Y
Q
A
G
M
-
S
--
E
R
G
R
E
F
A
A
K
H
A
E
C
V
F
L
G
G
K
-
D
V
E
T
L
K
-
F
F
V
D
D
I
R
K
R
A
K
K
Y
G
R
N
P
D
H
I
K
M
F
A
G
I
C
V
I
V
G
K
T
H
D
E
A
M
E
K
L
N
S
F
-
Q
K
Y
W
S
L
-
E
----
G
H
L
A
H
Y
G
G
G
T
GY
D
L
S
K
Y
S
S
N
D
Y
I
G
S
I
---------
S
---
V
G
E
I
I
N
N
M
S
---
K
---
L
D
G
K
W
F
K
--------------------------
L
S
V
G
T
P
K
K
V
A
D
E
M
Q
Y
L
V
E
E
A
-
G
I
D
G
F
N
L
V
Q
Y
---
V
------
S
-----
P
G
T
F
V
D
F
I
E
L
V
V
P
E
L
Q
K
R
G
L
Y
R
V
D
Y
E
E
G
T
Y
R
E
-------------
4
PsiBlast_PDB
71.82
35%
47
- C3 -
3B9N
-
?
A:
[3-414]
-----
K
K
I
H
I
N
A
F
E
M
N
C
V
G
H
I
A
H
GL
W
R
H
P
E
N
Q
R
H
R
Y
T
D
L
N
Y
W
T
E
L
A
Q
L
L
E
K
G
K
F
D
A
L
F
L
A
D
V
--
V
G
I
YDVYRQSR
D
T
A
V
R
E
---------
A
V
Q
I
P
V
N
D
P
L
M
L
I
S
A
M
A
Y
V
T
K
H
L
A
F
A
V
T
-
F
-
S
T
T
-
Y
E
H
P
Y
G
H
A
R
R
M
S
T
L
D
H
L
T
K
G
R
I
A
W
N
V
V
T
S
H
L
P
--
S
A
D
K
N
F
G
I
K
K
I
-
L
E
H
D
E
R
Y
D
L
A
D
E
Y
L
E
V
C
Y
K
L
W
E
G
S
-
W
E
D
N
A
V
I
R
D
I
E
N
N
I
Y
T
D
P
-
S
K
V
H
E
I
N
H
S
G
K
Y
F
E
V
P
G
P
-
H
---------
L
C
E
P
S
P
Q
-
R
T
P
V
I
Y
Q
A
G
M
-
S
--
E
R
G
R
E
F
A
A
K
H
A
E
C
V
F
L
G
G
K
-
D
V
E
T
L
K
-
F
F
V
D
D
I
R
K
R
A
K
K
Y
G
R
N
P
D
H
I
K
M
F
A
G
I
C
V
I
V
G
K
T
H
D
E
A
M
E
K
L
N
S
F
-
Q
K
Y
W
S
L
-
E
----
G
H
L
A
H
Y
G
G
G
T
GY
D
L
S
K
Y
S
S
N
D
Y
I
G
S
I
---------
S
---
V
G
E
I
I
N
N
M
S
---
K
---
L
D
G
K
W
F
K
--------------------------
L
S
V
G
T
P
K
K
V
A
D
E
M
Q
Y
L
V
E
E
A
-
G
I
D
G
F
N
L
V
Q
Y
---
V
------
S
-----
P
G
T
F
V
D
F
I
E
L
V
V
P
E
L
Q
K
R
G
L
Y
R
V
D
Y
E
E
G
T
Y
R
E
-------------
17
HHSearch
70.39
38%
31
- C3 -
3B9O
1
?
A:
[33-420]
-----------------------------------
Y
T
D
L
N
Y
W
T
E
L
A
Q
L
L
E
K
G
K
F
D
A
L
F
L
A
D
V
--
V
G
I
--------
Y
D
V
Y
R
Q
SR
D
T
A
V
R
E
A
V
Q
-
I
P
V
N
D
P
L
M
L
I
S
A
M
A
Y
V
T
K
H
L
A
F
A
V
T
-
F
-
S
T
T
-
Y
E
H
P
Y
G
H
A
R
R
M
S
T
L
D
H
L
T
K
G
R
I
A
W
N
V
V
T
S
H
L
P
--
S
A
D
K
N
F
G
I
K
K
I
-
L
E
H
D
E
R
Y
D
L
A
D
E
Y
L
E
V
C
Y
K
L
W
E
-
G
S
W
E
D
N
A
V
I
R
D
I
E
N
N
I
Y
T
D
P
-
S
K
V
H
E
I
N
H
S
G
K
Y
F
E
V
P
G
P
-
H
---------
L
C
E
P
S
P
Q
-
R
T
P
V
I
Y
Q
A
G
M
-
S
--
E
R
G
R
E
F
A
A
K
H
A
E
C
V
F
L
G
G
K
-
D
V
E
T
L
K
-
F
F
V
D
D
I
R
K
R
A
K
K
Y
G
R
N
P
D
H
I
K
M
F
A
G
I
C
V
I
V
G
K
T
H
D
E
A
M
E
K
L
N
S
F
-
Q
K
Y
W
S
L
-
E
-
G
H
L
A
H
Y
G
G
G
T
G
-
Y
--
D
L
S
K
Y
S
S
N
----
D
--------------
Y
I
G
---------------
S
I
S
V
G
E
I
---
I
N
--
N
-
M
S
KL
D
G
-
K
W
F
----
K
L
S
V
G
T
P
K
K
V
A
D
E
M
Q
Y
L
V
E
E
A
-
G
I
D
G
F
N
L
V
Q
Y
---
V
------
S
-----
P
G
T
F
V
D
F
I
E
L
V
V
P
E
L
Q
K
R
G
L
Y
R
V
D
Y
E
E
G
T
Y
R
E
K
L
F
G
K
G
-------
19
HHSearch
66.02
22%
-46
- C3 -
3RAO
4
?
A:
[19-367]
----
F
Q
G
V
E
Y
G
F
W
L
P
I
F
----
G
G
--
W
L
R
N
V
N
D
E
S
M
P
P
T
F
E
Y
A
K
Q
T
A
Q
A
A
E
Q
L
G
F
S
T
T
L
I
A
E
L
--
N
L
N
--------
D
I
K
--
G
---------
V
S
-
A
P
S
L
E
A
W
T
T
A
A
A
L
A
A
V
T
D
R
L
E
I
M
T
A
-
V
-
R
P
G
-
F
H
N
P
A
V
T
A
K
M
A
A
N
I
D
Q
L
S
N
G
R
F
T
L
N
V
V
S
A
W
W
E
--
E
E
A
K
Q
Y
G
G
V
F
--
T
A
H
D
E
R
Y
D
R
T
E
E
F
V
T
I
L
K
G
L
W
K
-
E
-----------------------
E
E
F
S
Y
K
G
N
F
Y
E
L
H
H
T
-
H
---------
L
S
P
K
P
V
Q
K
Q
G
I
K
L
Y
A
G
G
E
-
S
--
K
R
G
K
E
V
I
V
N
H
A
D
A
Y
V
M
H
G
G
-
T
V
E
E
V
S
-
V
K
I
E
D
M
K
N
R
R
K
K
V
T
E
E
P
L
-
Q
S
F
G
L
A
A
Y
V
I
C
R
H
T
E
E
E
A
L
E
E
W
R
R
I
-
T
D
V
K
-------------
F
----------
V
S
K
S
-------------------
Q
L
E
Q
Q
--
V
----
K
---
L
N
D
Y
S
V
S
N
R
----------------
G
L
R
----
P
N
L
I
G
T
P
E
Q
I
A
E
R
I
L
A
F
E
K
V
G
--
V
T
L
L
L
L
Q
F
S
---
P
------
Q
-----
L
E
E
M
K
R
F
S
E
K
V
M
P
L
V
E
A
K
R
K
-------------------------
35
Fugue
65.90
21%
-61
- C3 -
1M41
-
SSUD_ECOLI
A:
[1-361]
------
S
L
N
M
F
W
F
L
P
T
H
G
---
D
G
--
H
Y
L
G
T
E
E
G
S
R
P
V
D
H
G
Y
L
Q
Q
I
A
Q
A
A
D
R
L
G
Y
T
G
V
L
I
P
T
G
--
R
S
C
--------
E
---------------------
D
A
W
L
V
A
A
S
M
I
P
V
T
Q
R
L
K
F
L
V
A
-
L
-
R
P
S
-
V
T
S
P
T
V
A
A
R
Q
A
A
T
L
D
R
L
S
N
G
R
A
L
F
N
L
V
T
G
S
D
P
--
Q
E
L
A
G
D
G
--
V
F
-
L
D
H
S
E
R
Y
E
A
S
A
E
F
T
Q
V
W
R
R
L
L
Q
-
R
-----------------------
E
T
V
D
F
N
G
K
H
I
H
V
R
G
A
K
L
---------
L
F
P
A
I
Q
Q
-
P
Y
P
P
L
Y
F
G
G
S
-
S
--
D
V
A
Q
E
L
A
A
E
Q
V
D
L
Y
L
T
W
G
E
-
P
P
E
L
V
K
-
E
K
I
E
Q
V
R
A
K
A
A
A
H
G
R
K
---
I
R
F
G
I
R
L
H
V
I
V
R
E
T
N
D
E
A
W
Q
A
A
E
R
L
-
I
S
-------------------------------
H
L
L
E
I
S
P
N
L
W
A
G
V
G
L
---
V
--------------------------------------
R
G
G
A
G
----
T
A
L
V
G
D
G
P
T
V
A
A
R
I
N
E
Y
A
A
L
G
--
I
D
S
F
V
L
S
G
Y
---
P
------
H
-----
L
E
E
A
Y
R
V
G
E
L
L
F
P
L
L
D
V
A
I
------------
P
E
I
P
Q
P
Q
P
L
-----
20
HHSearch
62.86
20%
-54
- C3 -
1NQK
-
SSUD_ECOLI
A:
[2-358]
------
S
L
N
M
F
W
F
L
P
T
---
H
G
D
G
--
H
Y
L
G
T
E
E
G
S
R
P
V
D
H
G
Y
L
Q
Q
I
A
Q
A
A
D
R
L
G
Y
T
G
V
L
I
P
T
G
--
R
S
-----------------------------
C
E
D
A
W
L
V
A
A
S
M
I
P
V
T
Q
R
L
K
F
L
V
A
-
L
-
R
P
S
-
V
T
S
P
T
V
A
A
R
Q
A
A
T
L
D
R
L
S
N
G
R
A
L
F
N
L
V
T
G
S
D
P
--
Q
E
L
A
G
D
G
V
F
---
L
D
H
S
E
R
Y
E
A
S
A
E
F
T
Q
V
W
R
R
L
L
Q
-
R
-----------------------
E
T
V
D
F
N
G
K
H
I
H
V
R
G
A
-
K
---------
L
L
F
P
A
I
Q
Q
P
Y
P
P
L
Y
F
G
G
S
-
S
--
D
V
A
Q
E
L
A
A
E
Q
V
D
L
Y
L
T
W
G
E
-
P
P
E
L
V
K
-
E
K
I
E
Q
V
R
A
K
A
A
A
H
G
R
K
---
I
R
F
G
I
R
L
H
V
I
V
R
E
T
N
D
E
A
W
Q
A
A
E
R
L
-
I
S
H
L
D
D
-
E
--
T
I
A
K
A
Q
A
A
F
A
-------
R
-----------------------------------
D
---
N
L
E
I
S
P
N
L
W
---
A
G
VG
L
-
V
---
R
G
-
G
A
G
----
T
A
L
V
G
D
G
P
T
V
A
A
R
I
N
E
Y
A
A
L
--
G
I
D
S
F
V
L
S
G
Y
---
P
------
H
-----
L
E
E
A
Y
R
V
G
E
L
L
F
P
L
L
D
V
A
I
P
E
I
P
Q
---------------------
25
HHSearch
57.13
17%
-13
- C3 -
1RHC
5
?
A:
[2-330]
------
K
T
Q
I
G
Y
F
A
S
L
E
------------------
Q
Y
R
P
M
D
A
L
E
Q
A
I
R
A
E
K
V
G
F
D
S
V
W
V
D
D
H
--
F
H
P
--------
W
Y
H
D
------------
N
-
A
Q
S
A
Q
A
W
A
W
M
G
A
A
L
Q
A
T
K
K
V
F
I
S
T
C
-
I
T
C
P
I
M
R
Y
N
P
A
I
V
A
Q
T
F
A
T
L
R
Q
M
Y
P
G
R
V
G
V
A
V
G
A
G
E
A
M
--
N
E
V
P
V
T
G
E
W
---
P
S
V
P
V
R
Q
D
M
T
V
E
A
V
K
V
M
R
M
L
W
E
-
S
-
D
---------------------
K
P
V
T
F
K
G
D
Y
F
T
L
D
K
A
-
F
---------
L
Y
T
K
P
D
D
--
E
V
P
L
Y
F
S
G
M
-
G
--
P
K
G
A
K
L
A
G
M
Y
G
D
H
L
M
T
V
A
A
-
A
P
S
T
L
K
N
V
T
I
P
K
F
E
E
G
A
R
E
A
G
K
D
P
S
K
M
E
H
A
M
L
I
W
Y
S
V
D
P
D
Y
D
K
A
V
E
A
L
R
F
W
-
A
G
C
L
V
P
-
S
---
M
---
F
K
-
Y
K
-------
V
Y
D
P
K
----
E
---------------
V
Q
-----
L
---
H
---
A
N
L
V
H
C
D
T
I
----------------
K
E
N
----
Y
M
C
A
T
D
A
E
E
M
I
K
E
I
E
R
F
K
E
A
--
G
I
N
H
F
C
L
G
N
S
SP-
D
------
V
-----
N
F
G
I
D
I
F
-
K
E
V
I
P
A
V
R
D
----------------------------
21
HHSearch
55.58
14%
-15
- C3 -
1LUC
6
LUXA_VIBHA
A:
[1-354]
-------
M
K
F
G
N
F
L
L
T
Y
--
Q
P
P
-------
E
L
--
S
Q
T
E
V
M
K
R
L
V
N
L
G
K
A
S
E
G
C
G
F
D
T
V
W
L
L
E
H
--
H
F
T
--------
E
F
G
----------------
L
L
G
N
P
Y
V
A
A
A
H
L
L
G
A
T
E
T
L
N
V
G
T
A
A
I
-
V
L
P
-
T
A
H
P
V
R
Q
A
E
D
V
N
L
L
D
Q
M
S
K
G
R
F
R
F
G
I
C
R
G
L
Y
D
--
K
D
F
R
V
F
G
T
-----
D
M
D
N
S
R
A
L
M
D
C
W
Y
D
L
M
K
E
G
F
N
-
E
-----------------------
G
Y
I
A
A
D
N
E
H
I
K
F
P
K
I
-
Q
---------
L
N
P
S
A
Y
T
Q
G
G
A
P
V
Y
V
V
A
E
-
S
--
A
S
T
T
E
W
A
A
E
R
G
L
P
M
I
L
S
W
I
I
N
T
H
E
K
K
-
A
Q
L
D
L
Y
N
E
V
A
T
E
H
G
Y
D
V
T
K
I
D
H
C
L
S
Y
I
T
S
V
D
H
D
S
N
R
A
K
D
I
C
R
N
F
-
L
G
H
W
Y
D
-
S
------
Y
V
N
A
T
K
I
F
-----------------------------------------------------
R
---
I
---------
D
Y
-
S
Y
E
----
I
N
P
V
G
T
P
E
E
C
I
A
I
I
Q
Q
D
I
D
A
T
-
G
I
D
N
I
C
C
G
F
E
---
A
NGS
E
E
E
I
-----
I
A
S
M
K
L
F
Q
S
D
V
M
P
Y
L
K
E
K
---------------------------
30
HHSearch
54.24
17%
-24
- C3 -
1F07
3
MER_METTM
A:
[1-321]
-------
M
K
F
G
I
E
F
V
P
------------------
N
-
E
P
I
E
K
I
V
K
L
V
K
L
A
E
D
V
G
F
E
Y
A
W
I
T
D
H
--
Y
N
-----------------------------
N
K
N
V
Y
E
T
L
A
L
I
A
E
G
T
E
T
I
K
L
G
P
G
-
V
T
N
P
Y
-
V
R
S
P
A
I
T
A
S
A
I
A
T
L
D
E
L
S
N
G
R
A
T
L
G
I
G
P
G
D
-
K
--
A
T
F
D
A
L
G
I
-----
E
W
V
K
P
V
S
T
I
R
D
A
I
A
M
M
R
T
L
L
A
-
G
-----------------------
E
K
T
E
-
S
G
A
Q
L
----------------
M
G
V
K
A
V
Q
-
E
K
I
P
I
Y
M
G
A
Q
-
G
--
P
M
M
L
K
T
A
G
E
I
S
D
G
A
L
I
N
A
S
-
N
P
K
D
F
E
-
A
A
V
P
L
I
K
E
G
A
E
A
A
G
K
S
I
A
D
I
D
V
A
A
Y
T
C
C
S
I
D
E
D
A
A
A
A
A
N
A
A
K
I
V
-
V
A
F
I
A
A
-
G
--
S
P
P
P
V
F
E
R
H
G
--------
L
P
A
D
-
T
G
K
K
--------
F
G
E
---
L
L
G
K
-
G
D
F
G
---
G
---
A
I
G
A
V
D
D
A
L
----------------
M
E
A
----
F
S
V
V
G
T
P
D
E
F
I
P
K
I
E
A
L
G
E
M
--
G
V
T
Q
Y
V
A
G
S
P
IGP
D
------
K
-----
E
K
S
I
K
L
L
G
E
V
I
A
S
F
-------------------------------
27
HHSearch
52.53
16%
-1
- C3 -
4UWM
5
C16MO_PSEPU
A:
[2-376]
------
A
M
E
T
G
L
I
F
H
P
Y
--
M
R
P
-------
G
R
--
S
A
R
Q
T
F
D
W
G
I
K
S
A
V
Q
A
D
S
V
G
I
D
S
M
M
I
S
E
H
--
A
S
Q
--------
I
W
E
----------------
N
I
P
N
P
E
L
L
I
A
A
A
A
L
Q
T
K
N
I
K
F
A
P
M
A
H
-
L
L
P
-
H
Q
H
P
A
K
L
A
T
M
I
G
W
L
S
Q
I
L
E
G
R
Y
F
L
G
I
G
A
G
A
Y
P
--
Q
A
S
Y
M
H
G
I
R
N
A
G--
T
K
N
L
N
D
M
V
R
E
S
L
F
I
M
E
K
I
W
K
-
R
-----------------------
E
P
F
F
H
E
G
K
Y
W
D
A
G
Y
P
-
E
E
LEDEQHKL
A
D
F
S
P
W
G
G
K
A
P
E
I
A
V
T
G
F
-
S
YN
S
P
S
M
R
L
A
G
E
R
N
F
K
P
V
S
I
F
S
-
G
L
D
A
L
K
-
R
H
W
E
V
Y
S
E
A
A
I
E
A
G
H
T
P
D
R
S
R
H
A
V
S
H
T
V
F
C
A
D
T
D
K
E
A
K
R
L
V
M
E
G
P
I
G
Y
C
F
E
---
R
Y
L
I
P
I
W
R
R
F
G
--------
M
M
D
--------------------
G
Y
A
K
D
A
G
I
----
D
---
P
V
D
A
D
L
E
F
L
----------------
V
D
N
----
V
F
L
V
G
S
P
D
T
V
T
E
K
I
N
A
L
F
E
A
T
G
G
W
G
T
L
Q
V
E
A
H
---
D
YYD---
D
P
A
P
W
-
F
Q
S
L
E
L
I
S
K
E
V
A
P
K
I
L
L
P
---------------------------
31
HHSearch
52.26
16%
-41
- C3 -
4US5
9
?
A:
[4-337]
------
H
V
K
L
S
V
V
E
Q
A
----
P
V
V
--
E
G
L
-----
T
P
A
H
S
L
Q
H
S
I
E
L
A
R
L
A
D
R
L
G
Y
E
R
F
W
V
A
E
H
--
H
A
E
--------
I
F
N
----------------
A
V
P
A
P
E
I
L
I
A
R
I
A
A
E
T
S
G
I
R
V
G
S
G
G
V
-
L
L
S
-
L
Y
S
P
L
K
V
A
E
V
F
R
T
L
H
A
L
Y
P
D
R
I
D
L
G
I
G
R
A
N
R
V
K
L
P
V
F
A
A
L
R
D
D
--------
S
S
D
D
L
W
R
R
L
E
Q
L
R
A
Y
L
D
-
P
-----------------------
D
----
S
G
L
P
F
T
---------------
V
S
P
R
M
P
--
G
G
P
A
L
W
L
L
G
A
-
S
--
V
S
S
A
E
A
A
A
R
L
G
L
P
Y
A
Y
A
H
F
I
T
P
Q
F
T
R
-
E
A
M
D
T
Y
R
A
A
F
V
P
G
P
D
T
P
-
S
P
R
P
I
L
S
V
V
V
C
C
A
E
T
D
A
E
A
Q
R
V
Y
A
T
H
-
R
L
F
H
R
R
-
M
-
S
-----
Q
G
D
V
R
-------
L
L
P
P
A
-
D
L
A
---------------
V
A
----
E
M
D
---------
K
P
G
P
D
P
L
---
A
E
--
E
-
S
---
F
--
E
W
P
----
R
Y
V
V
G
S
P
D
R
V
R
D
Q
L
T
K
M
A
D
A
T
-
G
A
E
E
L
G
V
V
S
M
---
I
------
H
D
Q
R
D
R
L
R
S
Y
R
L
L
A
E
A
F
E
L
T
P
------------------------------