@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu39550: (2016-08-05 )
MYKLIAIDMDGTLLNDHHEVTEEVRDALHAAKAEGVKIVLCTGRPIGGVQRYLDELNLIEEGDYVIAYNGALVQNTHTNEVVSELSLGYDDLTSLYDLSLELKTPMHFFDSSNLYTPNRDISEFTVYESYVTQVPLHFRKIDEVPKDILIPKVMFIDKPENLSRVITSIPKDVREKYTMVRSAPFFYEILHSEASKGNAVRQLAQLLGIEQAEVMCIGDNGNDLTMIEWAGCGVAMANAIPEVLEAANFQTRSNNEHGVAHAIHELVLAK
Atome Classification :
(20 SA)
.........10....-..-..20........30........40........50.--...-....60........70.....----...80........90........100......---.110....-----..--.120-..-...-...130.---.....-----------.---.--140---.-.---.-....-------150-......-..160.....-..170.----------......180.......190.......200.......210.......220.......230.......240.......250.......260.......270
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
Y
K
L
I
A
IDMDGTLLN-
D
H
-
H
E
V
T
E
E
V
R
D
A
L
H
A
AKAE
G
V
K
I
V
L
CTGRPI
G
G
V
Q
R
Y
--
L
D
E
-LNLIEEG
D
Y
V
I
A
YN
G
A
L
V
QNT----
H
T
N
E
V
V
S
E
L
SL
G
Y
D
D
L
T
S
L
Y
D
L
S
L
E
LKT
P
M
H
F---FDSSNLYT-----PN--RDI--
S
E
-
F
T
V
-
Y
E
S
Y
V
-
T
---QV
P
L
H
-----------
F
---
R
--
K
I
D
---E-V---
P
-
K
D
IL-------I
P
--
K
V
M
F
ID-K
P
E
N
L
S
R
V
I
T
-SI
P
K
D
V
----------
R
E
K
Y
T
M
VRSA
P
F
F
Y
E
I
L
HSEASKG
N
A
V
R
Q
L
A
Q
L
LGIEQ
A
E
V
M
C
IGDNGN
D
L
T
M
I
E
WAGC
G
V
A
M
A
N
A
I
P
E
V
L
E
A
ANFQTRSNNEH
G
V
A
H
A
I
H
E
L
VLAK--
79
HHSearch
98.09
50%
-124
- C1 -
1RKQ
2
YIDA_ECOLI
A:
[4-271]
A
I
K
L
I
A
I
D
M
D
G
T
L
L
L
-
P
D
-
H
T
I
S
P
A
V
K
N
A
I
A
A
A
R
A
R
G
V
N
V
V
L
T
T
G
R
P
Y
A
G
V
H
N
Y
--
L
K
E
-
L
H
M
E
Q
P
G
D
Y
C
I
T
Y
N
G
A
L
V
Q
K
A
----
A
D
G
S
T
V
A
Q
T
A
L
S
Y
D
D
Y
R
F
L
E
K
L
S
R
E
V
G
S
H
F
H
A
---
L
D
R
T
T
L
Y
T
-----
A
N
--
R
D
I
--
S
Y
-
Y
T
V
-
H
E
S
F
V
-
A
---
T
I
P
L
V
-----------
F
---
C
--
E
A
E
---
K
-
M
---
D
-
P
N
T
Q
-------
F
L
--
K
V
M
M
I
D
-
E
P
A
I
L
D
Q
A
I
A
-
R
I
P
Q
E
V
----------
K
E
K
Y
T
V
L
K
S
A
P
Y
F
L
E
I
L
D
K
R
V
N
K
G
T
G
V
K
S
L
A
D
V
L
G
I
K
P
E
E
I
M
A
I
G
D
Q
E
N
D
I
A
M
I
E
Y
A
G
V
G
V
A
V
D
N
A
I
P
S
V
K
E
V
A
N
F
V
T
K
S
N
L
E
D
G
V
A
F
A
I
E
K
Y
V
L
----
1
PsiBlast_PDB
95.87
50%
-121
- C1 -
1RKQ
2
YIDA_ECOLI
A:
[6-271]
--
K
L
I
A
I
D
M
D
G
T
L
L
L
-
P
D
-
H
T
I
S
P
A
V
K
N
A
I
A
A
A
R
A
R
G
V
N
V
V
L
T
T
G
R
P
Y
A
G
V
H
N
Y
--
L
K
E
-
L
H
M
E
Q
P
G
D
Y
C
I
T
Y
N
G
A
L
V
Q
K
A
----
A
D
G
S
T
V
A
Q
T
A
L
S
Y
D
D
Y
R
F
L
E
K
L
S
R
E
V
G
S
H
F
H
A
---
L
D
R
T
T
L
Y
T
-----
A
N
--
R
D
I
--
S
Y
-
Y
T
V
-
H
E
S
F
V
-
A
---
T
I
P
L
V
-----------
F
---
C
--
E
A
E
---
K
-
M
---
D
-
P
N
T
Q
-------
F
L
--
K
V
M
M
I
D
-
E
P
A
I
L
D
Q
A
I
A
-
R
I
P
Q
E
V
----------
K
E
K
Y
T
V
L
K
S
A
P
Y
F
L
E
I
L
D
K
R
V
N
K
G
T
G
V
K
S
L
A
D
V
L
G
I
K
P
E
E
I
M
A
I
G
D
Q
E
N
D
I
A
M
I
E
Y
A
G
V
G
V
A
V
D
N
A
I
P
S
V
K
E
V
A
N
F
V
T
K
S
N
L
E
D
G
V
A
F
A
I
E
K
Y
V
L
----
21
PsiBlast_CBE
95.76
50%
-122
- C1 -
1RKQ
2
YIDA_ECOLI
B:
[6-271]
--
K
L
I
A
I
D
M
D
G
T
L
L
L
-
P
D
-
H
T
I
S
P
A
V
K
N
A
I
A
A
A
R
A
R
G
V
N
V
V
L
T
T
G
R
P
Y
A
G
V
H
N
Y
--
L
K
E
-
L
H
M
E
Q
P
G
D
Y
C
I
T
Y
N
G
A
L
V
Q
K
A
----
A
D
G
S
T
V
A
Q
T
A
L
S
Y
D
D
Y
R
F
L
E
K
L
S
R
E
V
G
S
H
F
H
A
---
L
D
R
T
T
L
Y
T
-----
A
N
--
R
D
I
--
S
Y
-
Y
T
V
-
H
E
S
F
V
-
A
---
T
I
P
L
V
-----------
F
---
C
--
E
A
E
---
K
-
M
---
D
-
P
N
T
Q
-------
F
L
--
K
V
M
M
I
D
-
E
P
A
I
L
D
Q
A
I
A
-
R
I
P
Q
E
V
----------
K
E
K
Y
T
V
L
K
S
A
P
Y
F
L
E
I
L
D
K
R
V
N
K
G
T
G
V
K
S
L
A
D
V
L
G
I
K
P
E
E
I
M
A
I
G
D
Q
E
N
D
I
A
M
I
E
Y
A
G
V
G
V
A
V
D
N
A
I
P
S
V
K
E
V
A
N
F
V
T
K
S
N
L
E
D
G
V
A
F
A
I
E
K
Y
V
L
----
78
HHSearch
82.64
43%
-132
- C1 -
3MPO
-
?
A:
[3-264]
-
I
K
L
I
A
I
D
I
-------------
A
Q
A
T
I
D
A
V
Q
A
A
K
A
Q
G
I
K
V
V
L
C
T
G
R
P
L
T
G
V
Q
P
Y
--
L
D
A
-
M
D
I
D
G
D
D
Q
Y
A
I
T
F
N
G
S
V
A
Q
T
I
----
S
-
G
K
V
L
T
N
H
S
L
T
Y
E
D
Y
I
D
L
E
A
W
A
R
K
V
R
A
H
F
Q
I
---
E
T
P
D
Y
I
Y
T
-----
A
N
--
K
D
I
--
S
A
-
Y
T
I
-
A
E
S
Y
L
-
V
---
R
M
L
I
Q
-----------
Y
---
R
--
E
V
S
---
E
-
T
---
P
-
R
D
L
T
-------
I
S
--
K
A
M
F
V
D
-
Y
P
Q
V
I
E
Q
V
K
A
-
N
M
P
Q
D
F
----------
K
D
R
F
S
V
V
Q
S
A
P
Y
F
I
E
V
M
N
R
R
A
S
K
G
G
T
L
S
E
L
V
D
Q
L
G
L
T
A
D
D
V
M
T
L
--
Q
G
N
D
L
T
M
I
K
Y
A
G
L
G
V
A
M
---
I
D
E
V
K
E
A
A
Q
A
V
T
------
G
V
A
A
A
I
R
--------
70
Fugue
74.99
26%
-114
* C1 *
1NF2
3
?
A:
[1-267]
M
Y
R
V
F
V
F
D
L
D
G
T
L
L
N
-
D
N
-
L
E
I
S
E
K
D
R
R
N
I
E
K
L
S
-
R
K
C
Y
V
V
F
A
S
G
R
M
L
V
S
T
L
N
V
--
E
K
K
-
Y
F
--
K
R
T
F
P
T
I
A
Y
N
G
A
I
V
Y
L
P
----
E
E
G
V
I
L
N
E
-
K
I
P
P
E
V
A
K
D
I
I
E
Y
I
K
P
L
N
V
H
W
Q
A
---
Y
I
D
D
V
L
Y
S
-----
E
K
--
D
N
---
E
E
-
I
K
S
-
Y
A
R
H
S
-
N
---
V
D
Y
R
V
-----------
E
---
P
--
N
L
S
---
E
-
L
---
V
-
S
K
M
G
-------
T
T
--
K
L
L
L
I
D
-
T
P
E
R
L
D
E
L
K
E
-
I
L
S
E
R
F
----------
K
D
V
V
K
V
F
K
S
F
P
T
Y
L
E
I
V
P
K
N
V
D
K
G
K
A
L
R
F
L
R
E
R
M
N
W
K
K
E
E
I
V
V
F
G
D
N
E
N
D
L
F
M
F
E
E
A
G
L
R
V
A
M
E
N
A
I
E
K
V
K
E
A
S
D
I
V
T
L
T
N
N
D
S
G
V
S
Y
V
L
E
R
I
S
T
D
C
LD
84
HHSearch
70.56
29%
-52
- C1 -
4DW8
4
?
A:
[4-269]
K
Y
K
L
I
V
L
D
L
D
G
T
L
T
N
-
S
K
-
K
E
I
S
S
R
N
R
E
T
L
I
R
I
Q
E
Q
G
I
R
L
V
L
A
S
G
R
P
T
Y
G
I
V
P
L
--
A
N
E
-
L
R
M
N
E
F
G
G
F
I
L
S
Y
N
G
G
E
I
I
N
W
----
E
S
K
E
M
M
Y
E
N
V
L
P
N
E
V
V
P
V
L
Y
E
C
A
R
T
N
H
L
S
I
L
T
---
Y
D
G
A
E
I
V
T
-----
E
N
--
S
L
D
---
P
-
Y
V
Q
-
K
E
A
F
L
-
N
---
K
M
A
I
R
------------------
E
T
N
---
D
F
L
---
T
D
I
T
L
P
-------
V
A
--
K
C
L
I
V
G
-
D
A
G
K
L
I
P
V
E
S
-
E
L
C
I
R
L
----------
Q
G
K
I
N
V
F
R
S
E
P
Y
F
L
E
L
V
P
Q
G
I
D
K
A
L
S
L
S
V
L
L
E
N
I
G
M
T
R
E
E
V
I
A
I
G
D
G
Y
N
D
L
S
M
I
K
F
A
G
M
G
V
A
M
G
N
A
Q
E
P
V
K
K
A
A
D
Y
I
T
L
T
N
D
E
D
G
V
A
E
A
I
E
R
I
F
-----
3
PsiBlast_PDB
70.47
29%
-50
- C1 -
3NIW
2
?
A:
[5-268]
-
Y
K
L
I
V
L
D
L
D
G
T
L
T
N
-
S
K
-
K
E
I
S
S
R
N
R
E
T
L
I
R
I
Q
E
Q
G
I
R
L
V
L
A
S
G
R
P
T
Y
G
I
V
P
L
--
A
N
E
-
L
R
M
N
E
F
G
G
F
I
L
S
Y
N
G
G
E
I
I
N
W
----
E
S
K
E
M
M
Y
E
N
V
L
P
N
E
V
V
P
V
L
Y
E
C
A
R
T
N
H
L
S
I
L
T
---
Y
D
G
A
E
I
V
T
-----
E
N
---
S
L
--
D
P
-
Y
V
Q
-
K
E
A
F
L
-
N
---
K
M
A
I
----------------
R
--
E
T
N
---
D
-
F
---
L
-
T
D
I
T
-------
L
P
VA
K
C
L
I
V
G
-
D
A
G
K
L
I
P
V
E
S
-
E
L
C
I
R
L
----------
Q
G
K
I
N
V
F
R
S
E
P
Y
F
L
E
L
V
P
Q
G
I
D
K
A
L
S
L
S
V
L
L
E
N
I
G
M
T
R
E
E
V
I
A
I
G
D
G
Y
N
D
L
S
M
I
K
F
A
G
M
G
V
A
M
G
N
A
Q
E
P
V
K
K
A
A
D
Y
I
T
L
T
N
D
E
D
G
V
A
E
A
I
E
R
I
------
2
PsiBlast_PDB
70.14
30%
-51
- C1 -
4DW8
4
?
A:
[5-268]
-
Y
K
L
I
V
L
D
L
D
G
T
L
T
N
-
S
K
-
K
E
I
S
S
R
N
R
E
T
L
I
R
I
Q
E
Q
G
I
R
L
V
L
A
S
G
R
P
T
Y
G
I
V
P
L
--
A
N
E
-
L
R
M
N
E
F
G
G
F
I
L
S
Y
N
G
G
E
I
I
N
W
----
E
S
K
E
M
M
Y
E
N
V
L
P
N
E
V
V
P
V
L
Y
E
C
A
R
T
N
H
L
S
I
L
T
---
Y
D
G
A
E
I
V
T
-----
E
N
---
S
L
--
D
P
-
Y
V
Q
-
K
E
A
F
L
-
N
---
K
--
M
A
-----------
I
---
R
--
E
T
N
---
D
-
F
---
L
-
T
D
I
T
-------
L
P
VA
K
C
L
I
V
G
-
D
A
G
K
L
I
P
V
E
S
-
E
L
C
I
R
L
----------
Q
G
K
I
N
V
F
R
S
E
P
Y
F
L
E
L
V
P
Q
G
I
D
K
A
L
S
L
S
V
L
L
E
N
I
G
M
T
R
E
E
V
I
A
I
G
D
G
Y
N
D
L
S
M
I
K
F
A
G
M
G
V
A
M
G
N
A
Q
E
P
V
K
K
A
A
D
Y
I
T
L
T
N
D
E
D
G
V
A
E
A
I
E
R
I
------
93
HHSearch
66.49
24%
-73
- C1 -
2PQ0
-
?
A:
[2-257]
G
R
K
I
V
F
F
D
I
D
G
T
L
L
D
-
E
Q
-
K
Q
L
P
L
S
T
I
E
A
V
R
R
L
K
Q
S
G
V
Y
V
A
I
A
T
G
R
A
P
F
M
F
E
H
V
--
R
K
Q
-
L
G
I
----
D
S
F
V
S
F
N
G
Q
Y
V
V
F
E
------
G
N
V
L
Y
K
Q
P
L
R
R
E
K
V
R
A
L
T
E
E
A
H
K
N
G
H
P
L
V
F
---
M
D
A
E
K
M
R
A
-----
S
I
--
G
D
H
--
P
---
H
I
-
H
V
----
S
---
M
A
S
L
K
-----------
F
---
A
HP
P
V
D
---
P
-
L
Y--
Y
-
E
N
K
D
-------
I
Y
--
Q
A
L
L
F
C
-
R
A
E
E
E
E
---
P
-
Y
V
R
N
-
Y
-----------
P
E
F
R
F
V
R
W
H
D
V
S
T
D
V
L
P
A
G
G
S
K
A
E
G
I
R
M
M
I
E
K
L
G
I
D
K
K
D
V
Y
A
F
G
D
G
L
N
D
I
E
M
L
S
F
V
G
T
G
V
A
M
G
N
A
H
E
E
V
K
R
V
A
D
F
V
T
K
P
V
D
K
E
G
I
W
Y
G
L
K
Q
L
Q
L
I
---
82
HHSearch
64.18
31%
-30
- C1 -
1NRW
3
YWPJ_BACSU
A:
[4-288]
-
M
K
L
I
A
I
D
L
D
G
T
L
L
N
-
S
K
-
H
Q
V
S
L
E
N
E
N
A
L
R
Q
A
Q
R
D
G
I
E
V
V
V
S
T
G
R
A
H
F
D
V
M
S
I
--
F
E
P
-
L
G
I
---
K
T
W
V
I
S
A
N
G
A
V
I
H
D
P
----
E
-
G
R
L
Y
H
H
E
T
I
D
K
K
R
A
Y
D
I
L
S
W
L
E
S
E
N
Y
Y
Y
E
V
---
F
T
G
S
A
I
Y
T
-----
P
Q
--
N
G
R
--
E
L
-
L
D
V
E
L
D
R
F
R
-
S
A
NP
E
A
D
L
S
V
L
K
Q
A
A
E
V
Q
Y
S
Q
SG
F
A
--
Y
I
N
SFQ
E
-
L
FEA
D
-
E
P
I
D
-------
F
Y
--
N
I
L
G
F
S
F
F
K
E
K
L
E
A
G
W
K
-
R
Y
E
--
H
----------
A
E
D
L
T
L
V
S
S
A
E
H
N
F
E
L
S
S
R
K
A
S
K
G
Q
A
L
K
R
L
A
K
Q
L
N
I
P
L
E
E
T
A
A
V
G
D
S
L
N
D
K
S
M
L
E
A
A
G
K
G
V
A
M
G
N
A
R
E
D
I
K
S
I
A
D
A
V
T
L
T
N
D
E
H
G
V
A
H
M
M
K
H
L
L
-----
8
PsiBlast_PDB
64.11
27%
-5
- C1 -
2RBK
2
?
A:
[1-255]
M
T
K
A
L
F
F
D
I
D
G
T
L
V
S
F
E
T
-
H
R
I
P
S
S
T
I
E
A
L
E
A
A
H
A
K
G
L
K
I
F
I
A
T
G
R
P
K
A
I
I
N
N
L
S
E
L
Q
D
-
R
N
L
I
---
D
G
Y
I
T
M
N
G
A
Y
C
--
F
----
V
G
E
E
V
I
Y
K
S
A
I
P
Q
E
E
V
K
A
M
A
A
F
C
E
K
K
G
V
P
C
I
F
---
V
E
E
H
N
I
S
V
C
Q---
P
N
--
E
M
V
--
K
K
-
I
F
Y
-
D
F
L
H
V
-
N
---
V
I
P
T
----------------
V
--
S
F
E
---
E
-
A
---
S
-
N
K
E
V
-------
I
Q
--
M
T
P
F
I
T
-
E
E
E
E
-
K
E
V
L
P
-
S
I
P
T
---------------
C
E
I
G
R
W
Y
P
A
F
A
D
V
T
A
K
G
D
T
K
Q
K
G
I
D
E
I
I
R
H
F
G
I
K
L
E
E
T
M
S
F
G
D
G
G
N
D
I
S
M
L
R
H
A
A
I
G
V
A
M
G
Q
A
K
E
D
V
K
A
A
A
D
Y
V
T
A
P
I
D
E
D
G
I
S
K
A
M
---------
10
PsiBlast_PDB
63.88
27%
-2
- C1 -
2RAV
2
?
A:
[1-255]
M
T
K
A
L
F
F
D
I
A
G
T
L
V
S
F
E
T
-
H
R
I
P
S
S
T
I
E
A
L
E
A
A
H
A
K
G
L
K
I
F
I
A
T
G
R
P
K
A
I
I
N
N
L
S
E
L
Q
D
-
R
N
L
I
---
D
G
Y
I
T
M
N
G
A
Y
C
--
F
----
V
G
E
E
V
I
Y
K
S
A
I
P
Q
E
E
V
K
A
M
A
A
F
C
E
K
K
G
V
P
C
I
F
---
V
E
E
H
N
I
S
V
C
Q---
P
N
--
E
M
V
--
K
K
-
I
F
Y
-
D
F
L
H
V
-
N
---
V
I
P
T
----------------
V
--
S
F
E
---
E
-
A
---
S
-
N
K
E
V
-------
I
Q
--
M
T
P
F
I
T
-
E
E
E
E
-
K
E
V
L
P
-
S
I
P
T
---------------
C
E
I
G
R
W
Y
P
A
F
A
D
V
T
A
K
G
D
T
K
Q
K
G
I
D
E
I
I
R
H
F
G
I
K
L
E
E
T
M
S
F
G
D
G
G
N
D
I
S
M
L
R
H
A
A
I
G
V
A
M
G
Q
A
K
E
D
V
K
A
A
A
D
Y
V
T
A
P
I
D
E
D
G
I
S
K
A
M
---------
7
PsiBlast_PDB
63.82
27%
-5
- C1 -
2RB5
2
?
A:
[1-255]
M
T
K
A
L
F
F
D
I
D
G
T
L
V
S
F
E
T
-
H
R
I
P
S
S
T
I
E
A
L
E
A
A
H
A
K
G
L
K
I
F
I
A
T
G
R
P
K
A
I
I
N
N
L
S
E
L
Q
D
-
R
N
L
I
---
D
G
Y
I
T
M
N
G
A
Y
C
--
F
----
V
G
E
E
V
I
Y
K
S
A
I
P
Q
E
E
V
K
A
M
A
A
F
C
E
K
K
G
V
P
C
I
F
---
V
E
E
H
N
I
S
V
C
Q---
P
N
--
E
M
V
--
K
K
-
I
F
Y
-
D
F
L
H
V
-
N
---
V
I
P
T
----------------
V
--
S
F
E
---
E
-
A
---
S
-
N
K
E
V
-------
I
Q
--
M
T
P
F
I
T
-
E
E
E
E
-
K
E
V
L
P
-
S
I
P
T
---------------
C
E
I
G
R
W
Y
P
A
F
A
D
V
T
A
K
G
D
T
K
Q
K
G
I
D
E
I
I
R
H
F
G
I
K
L
E
E
T
M
S
F
G
D
G
G
N
D
I
S
M
L
R
H
A
A
I
G
V
A
M
G
Q
A
K
E
D
V
K
A
A
A
D
Y
V
T
A
P
I
D
E
D
G
I
S
K
A
M
---------
9
PsiBlast_PDB
63.18
27%
-2
- C1 -
2RAR
2
?
A:
[1-255]
M
T
K
A
L
F
F
D
I
A
G
T
L
V
S
F
E
T
-
H
R
I
P
S
S
T
I
E
A
L
E
A
A
H
A
K
G
L
K
I
F
I
A
T
G
R
P
K
A
I
I
N
N
L
S
E
L
Q
D
-
R
N
L
I
---
D
G
Y
I
T
M
N
G
A
Y
C
--
F
----
V
G
E
E
V
I
Y
K
S
A
I
P
Q
E
E
V
K
A
M
A
A
F
C
E
K
K
G
V
P
C
I
F
---
V
E
E
H
N
I
S
V
C
Q---
P
N
--
E
M
V
--
K
K
-
I
F
Y
-
D
F
L
H
V
-
N
---
V
I
P
T
----------------
V
--
S
F
E
---
E
-
A
---
S
-
N
K
E
V
-------
I
Q
--
M
T
P
F
I
T
-
E
E
E
E
-
K
E
V
L
P
-
S
I
P
T
---------------
C
E
I
G
R
W
Y
P
A
F
A
D
V
T
A
K
G
D
T
K
Q
K
G
I
D
E
I
I
R
H
F
G
I
K
L
E
E
T
M
S
F
G
D
G
G
N
D
I
S
M
L
R
H
A
A
I
G
V
A
M
G
Q
A
K
E
D
V
K
A
A
A
D
Y
V
T
A
P
I
D
E
D
G
I
S
K
A
M
---------
16
PsiBlast_PDB
63.05
22%
-44
- C1 -
2QYH
5
?
A:
[4-257]
--
K
I
V
F
F
D
I
D
G
T
L
L
D
-
E
Q
-
K
Q
L
P
L
S
T
I
E
A
V
R
R
L
K
Q
S
G
V
Y
V
A
I
A
T
G
R
A
P
F
M
F
E
H
V
--
R
K
Q
-
L
G
I
----
D
S
F
V
S
F
N
G
Q
Y
V
--
V
----
F
E
G
N
V
L
Y
K
Q
P
L
R
R
E
K
V
R
A
L
T
E
E
A
H
K
N
G
H
P
L
V
F
---
M
D
A
E
K
M
R
A
SIGDH
P
H
--
I
H
V
--
S
M
-
A
S
L
-
K
F
A
H
P
-
P
---
V
D
P
L
Y
-----------
Y
---
E
--
N
K
D
----------------------
I
Y
--
Q
A
L
L
F
C
-
R
A
E
E
E
E
P
Y
V
R
-
N
Y
P
E
---------------
F
R
F
V
R
W
H
D
V
S
T
D
V
L
P
A
G
G
S
K
A
E
G
I
R
M
M
I
E
K
L
G
I
D
K
K
D
V
Y
A
F
G
D
G
L
N
D
I
E
M
L
S
F
V
G
T
G
V
A
M
G
N
A
H
E
E
V
K
R
V
A
D
F
V
T
K
P
V
D
K
E
G
I
W
Y
G
L
K
Q
L
Q
L
I
---
86
HHSearch
63.03
25%
-18
- C1 -
2RBK
2
?
A:
[1-260]
M
T
K
A
L
F
F
D
I
D
G
T
L
V
S
-
F
E
T
H
R
I
P
S
S
T
I
E
A
L
E
A
A
H
A
K
G
L
K
I
F
I
A
T
G
R
P
K
A
I
I
N
N
L
--
S
E
L
-
Q
D
R
N
-
L
I
D
G
Y
I
T
M
N
G
A
Y
C
F
V
G
------
E
E
V
I
Y
K
S
A
I
P
Q
E
E
V
K
A
M
A
A
F
C
E
K
K
G
V
P
C
I
F
---
V
E
E
H
N
I
S
V
-----
C
Q
--
P
N
E
--
M
V
K
K
I
F
-
Y
D
F
L
H
V
N
---
V
I
P
T
----------------
V
--
S
F
E
---
E
-----
A
-
S
N
K
E
-------
V
I
--
Q
M
T
P
F
I
-
T
E
E
E
E
K
E
V
----
L
P
-
S
I
-----------
P
T
C
E
I
G
R
W
Y
P
A
F
A
D
V
T
A
K
G
D
T
K
Q
K
G
I
D
E
I
I
R
H
F
G
I
K
L
E
E
T
M
S
F
G
D
G
G
N
D
I
S
M
L
R
H
A
A
I
G
V
A
M
G
Q
A
K
E
D
V
K
A
A
A
D
Y
V
T
A
P
I
D
E
D
G
I
S
K
A
M
K
H
F
G
I
----
15
PsiBlast_PDB
63.03
22%
-44
- C1 -
2PQ0
-
?
A:
[4-257]
--
K
I
V
F
F
D
I
D
G
T
L
L
D
-
E
Q
-
K
Q
L
P
L
S
T
I
E
A
V
R
R
L
K
Q
S
G
V
Y
V
A
I
A
T
G
R
A
P
F
M
F
E
H
V
--
R
K
Q
-
L
G
I
----
D
S
F
V
S
F
N
G
Q
Y
V
--
V
----
F
E
G
N
V
L
Y
K
Q
P
L
R
R
E
K
V
R
A
L
T
E
E
A
H
K
N
G
H
P
L
V
F
---
M
D
A
E
K
M
R
A
SIGDH
P
H
--
I
H
V
--
S
M
-
A
S
L
-
K
F
A
H
P
-
P
---
V
D
P
L
Y
-----------
Y
---
E
--
N
K
D
----------------------
I
Y
--
Q
A
L
L
F
C
-
R
A
E
E
E
E
P
Y
V
R
-
N
Y
P
E
---------------
F
R
F
V
R
W
H
D
V
S
T
D
V
L
P
A
G
G
S
K
A
E
G
I
R
M
M
I
E
K
L
G
I
D
K
K
D
V
Y
A
F
G
D
G
L
N
D
I
E
M
L
S
F
V
G
T
G
V
A
M
G
N
A
H
E
E
V
K
R
V
A
D
F
V
T
K
P
V
D
K
E
G
I
W
Y
G
L
K
Q
L
Q
L
I
---
6
PsiBlast_PDB
62.91
27%
-1
- C1 -
1YMQ
3
?
A:
[2-255]
-
T
K
A
L
F
F
D
I
D
G
T
L
V
S
F
E
T
-
H
R
I
P
S
S
T
I
E
A
L
E
A
A
H
A
K
G
L
K
I
F
I
A
T
G
R
P
K
A
I
I
N
N
L
S
E
L
Q
D
-
R
N
L
I
---
D
G
Y
I
T
M
N
G
A
Y
C
--
F
----
V
G
E
E
V
I
Y
K
S
A
I
P
Q
E
E
V
K
A
M
A
A
F
C
E
K
K
G
V
P
C
I
F
---
V
E
E
H
N
I
S
V
C
Q---
P
N
--
E
M
V
--
K
K
-
I
F
Y
-
D
F
L
H
V
-
N
---
V
I
P
T
----------------
V
--
S
F
E
---
E
-
A
---
S
-
N
K
E
V
-------
I
Q
--
M
T
P
F
I
T
-
E
E
E
E
-
K
E
V
L
P
-
S
I
P
T
---------------
C
E
I
G
R
W
Y
P
A
F
A
D
V
T
A
K
G
D
T
K
Q
K
G
I
D
E
I
I
R
H
F
G
I
K
L
E
E
T
M
S
F
G
D
G
G
N
D
I
S
M
L
R
H
A
A
I
G
V
A
M
G
Q
A
K
E
D
V
K
A
A
A
D
Y
V
T
A
P
I
D
E
D
G
I
S
K
A
M
---------
88
HHSearch
60.87
27%
4
- C1 -
1NF2
3
?
A:
[1-262]
M
Y
R
V
F
V
F
D
L
D
G
T
L
L
N
-
D
N
-
L
E
I
S
E
K
D
R
R
N
I
E
K
L
S
R
-
K
C
Y
V
V
F
A
S
G
R
M
L
V
S
T
L
N
V
--
E
K
K
Y
F
K
R
---
T
F
P
T
I
A
Y
N
G
A
I
V
Y
L
P
----
E
-
E
G
V
I
L
N
E
K
I
P
P
E
V
A
K
D
I
I
E
Y
I
K
P
L
N
V
H
W
Q
A
---
Y
I
D
D
V
L
Y
S
-----
E
K
--
D
N
E
--
E
I
--
K
S
-
Y
A
-
R
H
-
S
---
N
V
D
Y
R
-----------
V
---
E
P-
N
L
S
---
E
-
L
---
V
-
S
K
M
G
-------
T
T
--
K
L
L
L
I
D
-
T
P
E
R
L
D
E
L
K
E
-
I
L
S
E
R
F
----------
K
D
V
V
K
V
F
K
S
F
P
T
Y
L
E
I
V
P
K
N
V
D
K
G
K
A
L
R
F
L
R
E
R
M
N
W
K
K
E
E
I
V
V
F
G
D
N
E
N
D
L
F
M
F
E
E
A
G
L
R
V
A
M
E
N
A
I
E
K
V
K
E
A
S
D
I
V
T
L
T
N
N
D
S
G
V
S
Y
V
L
E
R
I
S
-----
4
PsiBlast_PDB
60.80
29%
-24
- C1 -
1NRW
3
YWPJ_BACSU
A:
[5-288]
--
K
L
I
A
I
D
L
D
G
T
L
L
N
-
S
K
-
H
Q
V
S
L
E
N
E
N
A
L
R
Q
A
Q
R
D
G
I
E
V
V
V
S
T
G
R
A
H
F
D
V
M
S
I
--
F
E
P
-
L
G
I
---
K
T
W
V
I
S
A
N
G
A
V
I
H
D
P
EGRL
Y
H
H
E
T
I
--------
D
K
K
R
A
Y
D
I
L
S
W
L
E
S
E
N
Y
Y
Y
E
V
F
T
G
S
A
I
Y
T
-----
P
Q
N
G
R
E
L
L
D
V
E
-
L
D
R
-
F
R
S
A
N
-
P
---
E
A
D
L
S
V
----------
L
---
K
--
Q
A
A
---
E
-
V
---
Q
-
Y
S
Q
S
G
F
A
Y
I
NS
F
Q
--
E
L
F
E
A
D
-
E
P
I
D
F
Y
N
I
L
G
F
S
F
F
K
E
K
L
E
A
G
W
K
R
YEH
A
E
D
L
T
L
V
S
S
A
E
H
N
F
E
L
S
S
R
K
A
S
K
G
Q
A
L
K
R
L
A
K
Q
L
N
I
P
L
E
E
T
A
A
V
G
D
S
L
N
D
K
S
M
L
E
A
A
G
K
G
V
A
M
G
N
A
R
E
D
I
K
S
I
A
D
A
V
T
L
T
N
D
E
H
G
V
A
H
M
M
K
H
L
L
-----