@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu39720: (2016-08-06 )
MGKNEILWGIAPIGWRNDDMPEIGAGNTLQHLLSDIVVARFQGTEVGGFFPEPAILNKELKLRNLRIAGKWFSSFILRDGLGEAAKTFTLHCEYLQQVNADVAVVSEQTYSVQSLEKNVFTEKPHFTDDEWERLCEGLNHLGEIAAQHGLKLVYHHHLGTGVQTAEEVDRLMAGTDPAHVHLLYDTGHAYISDGDYMGMLEKHIGRIKHVHFKDARLNVMEQCRLEGQSFRQSFLKGMFTVPGDGCIDFREVYQLLLKHSYSGWIVIEAEQDPDVANPLEYALIARNYIDQQLLDLA
Atome Classification :
(20 SA)
.........10........20........30..-----......40.......----.---------50---------.---------....--------....60.......-.----------------70.---.--.-------.-------------.----------------------.--.--.--80--..---------.......90........100..-.--.-..-..110.-......-120-....-...130.......140.......150......-----.--------160-....----------....-.170...-..-..180.......190.-..--....200...--....210......--.220-........230.......240.....-..250..-.....260..-.-....270..-.------------------.----------------.--..280.......290.....-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGKN
E
I
L
W
G
IAPIGWRNDDMPEIGA
G
N
T
L
Q
H
L
L
-----
S
D
I
V
V
A
RFQGTEVGG----F---------F----------P---------E
P
A
I--------LNK
E
L
K
L
R
N
L
R
I
A
-
G
----------------
K
W
F
---
S
--
S
-------
F
-------------
I
----------------------
L
--R--D--G---LG---------
E
A
A
K
T
F
T
L
H
C
E
Y
L
Q
QVNA
D
-
V
A
-
V
--
V
-SE-QT
Y
S
V
Q
-
S
L
E
K
NV-FTE-KPHF-
T
D
D
E
W
E
R
L
C
E
G
L
N
H
L
G
E
I
A
A
QHG
L
K
L
V
Y
HHHL-----G--------T---GVQ
T
----------
A
E
E
V
-
D
R
L
MAGT-DP-
A
H
V
H
L
L
Y
DTGHAYISD-G
D
--
Y
M
G
M
L
E
K
H
I
G
--RI
K
H
V
H
F
K
D
A
R
L
N
--
V
M
E
--
Q
CRLE
G
Q
S
F
R
Q
S
F
L
K
GMFTVPGDGCI-
D
F
R
E
V
Y
Q
-
L
L
L
KHSYS
G
W
-
I
-
V
I
EAEQDPD-V------------------A----------------
N
--
P
L
E
Y
A
L
I
A
R
N
Y
I
D
Q
Q
L
LDLA-
1
PsiBlast_PDB
90.42
63%
-32
- C3 -
3CNY
2
IOLE_LACPL
A:
[6-300]
-
A
E
K
D
I
K
W
G
I
A
P
I
G
W
R
N
D
D
I
P
S
I
G
K
D
N
N
L
Q
Q
L
L
-----
S
D
I
V
V
A
G
F
Q
G
T
E
V
G
G
----
F
---------
F
----------
P
---------
G
P
E
K
--------
L
N
Y
E
L
K
L
R
N
L
E
I
A
-
G
----------------
Q
W
F
---
S
--
S
-------
Y
-------------
I
----------------------
I
--
R
--
D
--
G
---
I
E
---------
K
A
S
E
A
F
E
K
H
C
Q
Y
L
K
A
I
N
A
P
-
V
A
-
V
--
V
-
S
E
-
Q
T
Y
T
I
Q
R
S
D
T
A
N
I
-
F
K
D
-
K
P
Y
F
-
T
D
K
E
W
D
E
V
C
K
G
L
N
H
Y
G
E
I
A
A
K
Y
G
L
K
V
A
Y
H
H
H
M
-----
G
--------
T
---
G
I
Q
T
----------
K
E
E
T
-
D
R
L
M
A
N
T
-
D
P
-
K
L
V
G
L
L
Y
D
T
G
H
I
A
V
S
D
-
G
D
--
Y
M
A
L
L
N
A
H
I
D
--
R
V
V
H
V
H
F
K
D
V
R
R
S
--
K
E
E
--
E
C
R
A
K
G
L
T
F
Q
G
S
F
L
N
G
M
F
T
V
P
G
D
G
D
L
-
D
F
K
P
V
Y
D
-
K
L
I
A
N
N
Y
K
G
W
-
I
-
V
V
E
A
E
Q
D
P
S
-
K
------------------
A
----------------
N
--
P
L
E
M
A
Q
I
A
H
R
Y
I
K
Q
H
L
I
E
---
31
HHSearch
89.02
62%
-32
* C3 *
3CNY
2
IOLE_LACPL
A:
[7-299]
--
E
K
D
I
K
W
G
I
A
P
I
G
W
R
N
D
D
I
P
S
I
G
K
D
N
N
L
Q
Q
L
L
-----
S
D
I
V
V
A
G
F
Q
G
T
E
V
G
G
----
F
---------
F
----------
P
---------
G
P
E
K
--------
L
N
Y
E
L
K
L
R
N
L
E
I
A
-
G
----------------
Q
W
F
---
S
--
S
-------
Y
-------------
I
----------------------
I
--
R
--
D
--
G
---
I
E
---------
K
A
S
E
A
F
E
K
H
C
Q
Y
L
K
A
I
N
A
P
-
V
A
V
V
--
S
-
E
Q
-
T
Y
T
I
Q
R
-
S
D
T
A
N
I
-
F
K
D
-
K
P
Y
F
-
T
D
K
E
W
D
E
V
C
K
G
L
N
H
Y
G
E
I
A
A
K
Y
G
L
K
V
A
Y
H
H
H
M
-----
G
--------
T
---
G
I
Q
T
----------
K
E
E
T
-
D
R
L
M
A
N
T
-
D
P
-
K
L
V
G
L
L
Y
D
T
G
H
I
A
V
S
D
-
G
D
--
Y
M
A
L
L
N
A
H
I
D
--
R
V
V
H
V
H
F
K
D
V
R
R
S
--
K
E
E
--
E
C
R
A
K
G
L
T
F
Q
G
S
F
L
N
G
M
F
T
V
P
G
D
G
D
L
-
D
F
K
P
V
Y
D
-
K
L
I
A
N
N
Y
K
G
W
-
I
-
V
V
E
A
E
Q
D
P
S
-
K
------------------
A
----------------
N
--
P
L
E
M
A
Q
I
A
H
R
Y
I
K
Q
H
L
I
----
47
HHSearch
52.99
17%
-3
- C3 -
3VNI
1
DPES_CLOCE
A:
[2-289]
-----
M
K
H
G
I
Y
Y
A
Y
W
E
Q
E
W
------
E
A
D
Y
K
Y
Y
I
-----
E
K
V
A
K
L
G
F
D
I
L
E
I
A
A
----
S
P--------
L
PFY-------
S
D
I
-------
Q
I
N
E
--------
L
K
A
C
A
H
G
N
G
I
T
L
T
-
V
----------------
G
H
G
---
P
--
S
AEQ----
N
-------------
L
----------------------
S
--
S
--
P
--
D
P
D
I
R
K
---------
N
A
K
A
F
Y
T
D
L
L
K
R
L
Y
K
L
D
V
H
-
L
I
-
G
--
G
-
A
L
-
Y
S
Y
W
P
I
-----
D
Y
-
T
---
K
T
I
D
-
K
K
G
D
W
E
R
S
V
E
S
V
R
E
V
A
K
V
A
E
A
C
G
V
D
F
C
L
E
V
L
N
RFE--
N
--------
Y
---
L
I
N
T
----------
A
Q
E
G
-
V
D
F
V
K
Q
V
-
D
H
-
N
N
V
K
V
M
L
D
T
F
H
M
N
I
E
E
-
D
S
--
I
G
G
A
I
R
T
A
G
S
--
Y
L
G
H
L
H
T
G
E
C
N
R
--------------------------
K
V
P
G
R
G
R
I
-
P
W
V
E
I
G
E
-
A
L
A
D
I
G
Y
N
G
S
-
V
-
V
M
E
P
F
V
R
M
G
-
G
------------------
T
V
G
S
N
I
KVWRDISNGAD
E
K
M
L
D
R
E
A
Q
A
A
L
D
F
S
R
Y
V
L
E
----
33
HHSearch
52.40
18%
-26
- C3 -
3KWS
4
?
A:
[23-285]
--
D
L
E
L
K
L
S
F
Q
E
G
I
A
P
---------
G
E
S
L
N
E
K
L
-----
D
F
M
E
K
L
G
V
V
G
F
E
P
G
G
----
G
---------
G
----------
L
AG-------
R
V
N
E
--------
I
K
Q
A
L
N
G
R
N
I
K
V
S
-
A
----------------
I
C
A
---
G
--
F
KG-----
F
-------------
I
----------------------
L
--
S
--
T
D
P
A
I
--
R
K
---------
E
C
M
D
T
M
K
E
I
I
A
A
A
G
E
L
G
S
T
-
G
V
-
I
--
I
V
P
A
-
F
N
G
--
Q
--------
V
P
A
--
L
P
H
-
T
M
E
T
R
D
F
L
C
E
Q
F
N
E
M
G
T
F
A
A
Q
H
G
T
S
V
I
F
E
P
L
N
-----
R
--------
K
ECF
Y
L
R
Q
----------
V
A
D
A
-
A
S
L
C
R
D
I
-
N
N
-
P
G
V
R
C
M
G
D
F
W
H
M
T
W
E
E
-
T
S
--
D
M
G
A
F
I
S
G
G
E
--
Y
L
Q
H
V
H
V
A
S
R
K
R
R
------------------------
S
M
P
G
E
D
G
D
A
D
N
Y
I
N
G
F
K
-
G
L
K
M
I
G
Y
N
N
Y
-
V
-
S
F
E
C
G
C
Q
G
D
----------------------------------------
R
N
V
V
V
P
A
A
V
K
L
L
R
E
Q
W
E
----
44
HHSearch
52.08
17%
-9
- C3 -
1K77
5
YGBM_ECOLI
A:
[1-258]
----
M
P
R
F
A
A
N
L
S
M
M
F
T
--------
E
V
P
F
I
E
R
F
-----
A
A
A
R
K
A
G
F
D
A
V
E
F
L
F
----
P
---------
Y
----------
N
Y--------
S
T
L
Q
--------
I
Q
K
Q
L
E
Q
N
H
L
T
L
A
-
L
----------------
F
N
T
---
A
--
P
-------
G
DINAGEW------
G
----------------------
L
--
S
--
A
LP
G
R--
E
H
---------
E
A
H
A
D
I
D
L
A
L
E
Y
A
L
A
L
N
C
E
-
Q
V
H
V
--
M
-
A
G
-
V
V
-------------
P
A
--
G
E
D
-
A
E
R
Y
R
A
V
F
I
D
N
I
R
Y
A
A
D
R
F
A
P
H
G
K
R
I
L
V
E
A
L
S
PGVKP
H
--------
Y
---
L
F
S
S
----------
Q
Y
Q
A
-
L
A
I
V
E
E
V
-
A
R
-
D
N
V
F
I
Q
L
D
T
F
H
A
Q
K
V
D
-
G
N
--
L
T
H
L
I
R
D
Y
A
G
--
K
Y
A
H
V
Q
I
A
G
L
P
D
-------------------------
R
H
E
P
D
D
G
E
I
-
N
Y
P
W
L
F
R
-
L
F
D
E
V
G
Y
Q
G
W
-
I
-
G
C
E
Y
K
P
R
G
L
--------------------------------------------
T
E
E
G
L
G
W
F
D
A
W
R
-----
30
Fugue
50.86
17%
-6
- C3 -
3CQJ
2
ULAE_ECO57
A:
[16-291]
Q
I
P
L
G
I
Y
E
K
A
L
P
A
G
E
C
W
L
E
R
L
Q
L
A
K
T
L
G
F
D
F
V
E
M
S
VDE
T
D
E
R
L
S
R
L
D
W
S
R
E
Q
R
----
L
---------
A
----------
L
---------
V
N
A
I
--------
V
E
T
G
V
R
V
P
S
M
C
L
S
-
A
----------------
H
R
R
---
F
--
P
-------
L
-------------
G
----------------------
S
ED
D
--
A
--
V
---
R
A
---------
Q
G
L
E
I
M
R
K
A
I
Q
F
A
Q
D
V
G
I
R
-
V
I
-
Q
--
L
-
A
---
G
Y
D
V
Y
-
Y
Q
E
A
N
------------
N
E
T
R
R
R
F
R
D
G
L
K
E
S
V
E
M
A
S
R
A
Q
V
T
L
A
M
E
I
M
D
-----
Y
--------
P
---
L
M
N
S
----------
I
S
K
A
-
L
G
Y
A
H
Y
L
-
N
N
-
P
W
F
Q
L
Y
P
D
I
G
N
L
S
A
W
D
-
N
D
--
V
Q
M
E
L
Q
A
G
I
G
--
H
I
V
A
V
H
V
K
D
T
K
P
G
--
V
F
K
--
N
V
P
-----------------
F
G
E
G
V
V
-
D
F
E
R
C
F
E
-
T
L
K
Q
S
G
Y
C
G
P
-
Y
-
L
I
E
M
W
S
E
T
A
--------------------
E
----------------
D
--
P
A
A
E
V
A
K
A
R
D
W
V
K
A
R
M
A
K
A
G
M
32
HHSearch
50.21
14%
-14
- C3 -
3U0H
5
?
A:
[3-278]
----
A
M
E
P
C
L
H
P
T
L
V
---------
D
E
T
S
L
V
L
Y
L
-----
D
L
A
R
E
T
G
Y
R
Y
V
D
V
P
F
----
H
---------
W
L
E
A
E
A
-----
E
R
H-------
G
D
A
A
--------
V
E
A
M
F
Q
R
R
G
L
V
L
A
-
N
----------------
L
G
L
---
P
--
L
-------
N
-------------
L
----------------------
Y
--
D
--
S
--
E
P
V
-
F
L
---------
R
E
L
S
L
L
P
D
R
A
R
L
C
A
R
L
G
A
R
-
S
V
-
T
--
A
-
F
L
-
W
P
S
------------
M
D
---
E
E
-
P
V
R
Y
I
S
Q
L
A
R
R
I
R
Q
V
A
V
E
L
L
P
L
G
M
R
V
G
L
E
Y
V
G
-----
P
HHLRHRRY
P
---
F
V
Q
S
----------
L
A
D
L
-
K
T
F
W
E
A
I
-
G
A
-
P
N
V
G
A
L
V
D
S
Y
H
W
Y
T
A
G
-
E
H
--
E
D
D
L
A
Q
L
P
P
E
--
K
V
V
Y
V
H
I
N
D
T
R
D
A
--
P
E
D
--------------
A
H
D
G
K
R
L
L
P
G
D
G
R
I
-
P
L
V
P
F
L
R
-
G
L
Y
L
A
G
Y
R
G
P
-
V
-
A
A
E
V
L
H
E
T
P
-
L
------------------
D
G---------------
T
--
G
E
S
R
A
R
L
V
R
E
R
L
E
K
L
I
A
L
---
42
HHSearch
49.61
14%
12
- C3 -
4XSL
5
DT3E_PSECI
A:
[1-291]
----
M
N
K
V
G
M
F
Y
T
Y
W
S
T
E
W
------
M
V
D
F
P
A
T
A
-----
K
R
I
A
G
L
G
F
D
L
M
E
I
S
L
----
G
---------
E
FHNLS-----
D
A
--------
K
K
R
E
--------
L
K
A
V
A
D
D
L
G
L
T
V
M
-
C
----------------
S
I
G
L
K
S
E
--
Y
-------
D
-------------
F
----------------------
A
--
S
--
P
--
D
K
S
V
R
D
---------
A
G
T
E
Y
V
K
R
L
L
D
D
C
H
L
L
G
A
P
-
V
F
-
A
--
G
-
L
T
F
C
A
W
P
Q
S
--------
P
P
L
-
D
M
K
D
-
K
R
P
Y
V
D
R
A
I
E
S
V
R
R
V
I
K
V
A
E
D
Y
G
I
I
Y
A
L
E
V
V
N
-----
R
FEQ-----
W
---
L
C
N
D
----------
A
K
E
A
-
I
A
F
A
D
A
V
-
D
S
-
P
A
C
K
V
Q
L
D
T
F
H
M
N
I
E
E
-
T
S
--
F
R
D
A
I
L
A
C
K
G
--
K
M
G
H
F
H
L
G
E
A
N
--------------------------
R
L
P
P
G
E
G
R
L
-
P
W
D
E
I
F
G
-
A
L
K
E
I
G
Y
D
G
T
-
I
-
V
M
E
P
F
M
R
K
G
-
G
S
V
S
R
A
V
GVWRDMSNGAT
D
E
----------------
E
--
M
D
E
R
A
R
R
S
L
Q
F
V
R
D
K
L
A
G
---
38
HHSearch
49.36
15%
-7
- C3 -
2ZDS
-
?
A:
[1-319]
----
P
R
N
F
T
L
F
T
G
Q
W
A
---------
D
L
P
L
E
E
V
C
-----
R
L
A
R
D
F
G
Y
D
G
L
E
L
A
C
----
W
---------
G
DHFE
V
D
K
A
L
A
D
P
S-------
Y
V
D
S
--------
R
H
Q
L
L
D
K
Y
G
L
K
C
W
-
A
----------------
I
S
N
---
H
--
L
-------
V
-------------
G
Q
A
VCDAIID
E
R
H
E
A
I
LPARIWG
D
--
G
--
D
--
A
E
G
V
R
Q
---------
R
A
A
A
E
I
K
D
T
A
R
A
A
A
R
L
G
V
D
T
V
I
-
G
--
F
-
T
G
-
S
A
I
W
H
L
-
V
---
A
M
-
F
P
P
A
P
E
S
M
-
I
E
R
G
Y
Q
D
F
A
D
R
W
N
P
I
L
D
V
F
D
A
E
G
V
R
F
A
H
E
V
H
P
-----
S
--------
E
---
I
A
Y
D
----------
Y
W
T
T
-
H
R
A
L
E
A
V
-
G
H
R
P
A
F
G
L
N
F
D
P
S
H
F
V
W
Q
D
-
L
D
--
P
V
G
F
L
W
D
F
R
D
--
R
I
Y
H
V
D
C
K
E
A
R
K
R
--
L
D
G
RN
G
R
L
G
S
H
L
P
W
G
D
P
R
R
G
W
D
F
V
S
A
G
H
G
D
V
-
P
W
E
D
V
F
R
-
M
L
R
S
I
D
Y
Q
G
P
-
V
-
S
V
E
W
E
D
A
G
M
-------------------------------------
D
--
R
L
Q
G
A
P
E
A
L
T
R
L
K
A
F
D
F
E
---
34
HHSearch
49.27
17%
-11
- C3 -
3CQJ
2
ULAE_ECO57
A:
[29-288]
-------------------------
G
E
C
W
L
E
R
L
-----
Q
L
A
K
T
L
G
F
D
F
V
E
M
S
V
----
D
---------
E
T
D
E
R
L
S
R
LDW
S
R
E
-------
Q
R
L
A
--------
L
V
N
A
I
V
E
T
G
V
R
V
P
-
S
----------------
M
C
L
---
S
--
A
H
R
R
F
---
P
-------------
L
----------------------
G
--
S
--
E
--
D
D
A
V
R
A
---------
Q
G
L
E
I
M
R
K
A
I
Q
F
A
Q
D
V
G
I
R
-
V
I
-
Q
--
L
-
A
G
-
Y
D
V
------------
Y
Y
--
Q
E
A
-
N
N
E
T
R
R
R
F
R
D
G
L
K
E
S
V
E
M
A
S
R
A
Q
V
T
L
A
M
E
I
M
D
-----
Y
--------
P
---
L
M
N
S
----------
I
S
K
A
-
L
G
Y
A
H
Y
L
-
N
N
-
P
W
F
Q
L
Y
P
D
I
G
N
L
S
A
W
D
-
N
D
--
V
Q
M
E
L
Q
A
G
I
G
--
H
I
V
A
V
H
V
K
D
T
K
P
G
--
V
-------------------
F
K
N
V
P
F
G
E
G
V
V
-
D
F
E
R
C
F
E
-
T
L
K
Q
S
G
Y
C
G
P
-
Y
-
L
I
E
M
W
S
E
T
A
-
E
-----------------------------------
D
--
P
A
A
E
V
A
K
A
R
D
W
V
K
A
R
M
A
K
---
35
HHSearch
49.20
14%
-7
- C3 -
3DX5
5
ASBF_BACAN
A:
[1-274]
-----
M
K
Y
S
L
C
T
I
S
F
R
H
Q
-------
L
I
S
F
T
D
I
V
-----
Q
F
A
Y
E
N
G
F
E
G
I
E
L
W
G
----
T
---------
H
----------
A
Q
N
L
Y
M
QE
Y
E
T
T
E
R
--------
E
L
N
C
L
K
D
K
T
L
E
I
T
-
M
----------------
I
S
D
---
Y
--
L
-------
D
-------------
I
----------------------
S
--
L
--
S
--
A
D--
F
E
---------
K
T
I
E
K
C
E
Q
L
A
I
L
A
N
W
F
K
T
N
K
I
R
-
T
--
F
-
A
G
-
Q
K
G
-------------
S
--
A
D
F
-
S
Q
Q
E
R
Q
E
Y
V
N
R
I
R
M
I
C
E
L
F
A
Q
H
N
M
Y
V
L
L
E
T
H
P
-----
N
--------
T
---
L
T
D
T
----------
L
P
S
T
-
L
E
L
L
G
E
V
-
D
H
-
P
N
L
K
I
N
L
D
F
L
H
I
W
E
S
G
-
A
D
--
P
V
D
S
F
Q
Q
L
R
P
--
W
I
Q
H
Y
H
F
K
N
I
S
S
A
--
D
Y
L
--
H
V
F
E
P
N
N
V
Y
A
A
A
G
N
R
T
G
M
V
P
L
F
E
G
I
V
-
N
Y
D
E
I
I
Q
-
E
V
R
D
T
--
D
H
F
-
A
-
S
L
E
W
F
G
H
N
-----------------------------------------
A
K
D
I
L
K
A
E
M
K
V
L
T
N
R
N
-----
18
PsiBlast_PDB
49.15
22%
-126
- C3 -
3DX5
3
ASBF_BACAN
A:
[113-201]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
-
S
Q
Q
E
R
Q
E
Y
V
N
R
I
R
M
I
C
E
L
F
A
Q
H
N
M
Y
V
L
L
E
T
H
P
-----
N
--------
T
---
L
T
D
T
----------
L
P
S
T
-
L
E
L
L
G
E
V
-
D
H
-
P
N
L
K
I
N
L
D
F
L
H
I
W
E
S
G
-
A
D
--
P
V
D
S
F
Q
Q
L
R
P
--
W
I
Q
H
Y
H
F
K
N
---------------------------------------------------------------------------------------------------------------------------------
24
Fugue
49.10
16%
-8
- C3 -
2ZDS
-
?
A:
[1-321]
----
P
R
N
F
T
L
F
T
G
Q
W
A
D
---------
L
P
L
E
E
V
C
-----
R
L
A
R
D
F
G
Y
D
G
L
E
L
A
C
WGDH
F
---------
E
----------
V
---------
D
K
A
L
A
D
P
S
Y
V
D
S
R
H
Q
L
L
D
K
Y
G
L
K
C
W
-
A
I
S
N
H
L
V
G
Q
A
VCDAIID
E
R
H
---
E
--
A
-------
I
-------------
L
----------------------
P
--
A
--
R
--
I
---
W
G
DGD
A
E
G
V
R
Q
R
A
A
A
E
I
K
D
T
A
R
A
A
A
R
L
G
V
D
-
T
V
-
I
--
G
-
F
T
-
G
S
---
A
-
I
W
H
L
V
A
M
F
P
P
-
A
P
E
S
M
I
E
R
G
Y
Q
D
F
A
D
R
W
N
P
I
L
D
V
F
D
A
E
G
V
R
F
A
H
E
V
H
P
-----
S
--------
E
---
I
A
Y
D
----------
Y
W
T
T
-
H
R
A
L
E
A
V
G
H
R
-
P
A
F
G
L
N
F
D
P
S
H
F
V
W
Q
D
-
L
D
--
P
V
G
F
L
W
D
F
R
D
--
R
I
Y
H
V
D
C
K
E
A
R
K
R
LD
G
R
N
--
G
R
L
G
S
H
L
P
W
G
D
P
R
R
G
W
D
F
V
S
A
G
H
G
D
V
-
P
W
E
D
V
F
R
M
L
R
-
S
I
D
Y
Q
G
P
-
V
-
S
V
E
W
E
---
D
-
A
------------------
G
M---------------
D
--
R
L
Q
G
A
P
E
A
L
T
R
L
K
A
F
D
F
E
P
P
-
40
HHSearch
48.79
14%
-17
- C3 -
3TVA
4
?
A:
[9-288]
---
P
Y
W
P
I
G
V
F
T
S
V
-----------
D
A
G
L
G
V
H
L
-----
E
V
A
Q
D
L
K
V
P
T
V
Q
V
H
A
----
P
---------
H
PHTRT-----
R
E
--------
H
A
Q
A
--------
F
R
A
K
C
D
A
A
G
I
Q
V
T
-
V
----------------
I
F
G
---
G
--
F
-------
D
GESYAD
I
P
T
T
A
R
T
V
----------------------
G
--
L
VP
L
--
E
T--
R
A
---------
S
R
V
A
E
M
K
E
I
S
D
F
A
S
W
V
G
C
P
-
A
I
-
G
--
L
-
H
I
-
G
F
------------
V
P
E
----
S
-
S
S
P
D
Y
S
E
L
V
R
V
T
Q
D
L
L
T
H
A
A
N
H
G
Q
A
V
H
L
E
T
G
Q
--------------------
E
S
----------
A
D
H
L
-
L
E
F
I
E
D
V
-
N
R
-
P
N
L
G
I
N
F
D
P
A
N
M
I
L
Y
G
T
G
N
--
P
I
E
A
L
R
K
V
A
R
--
Y
V
R
S
I
H
C
K
D
A
L
W
A
--
P
V
N
--
E
-
R
--
G
------
K
S
W
G
Q
E
V
A
L
G
T
G
D
V
-
G
M
E
A
Y
L
T
-
T
L
W
E
I
G
Y
R
G
P
-
L
-
T
I
E
R
E
I
P
H
D
-
P
------------------
V
----------------
Q
--
Q
K
K
D
L
A
S
A
L
E
L
L
T
G
L
R
K
K
I
A
-
41
HHSearch
48.30
20%
3
- C3 -
3VYL
1
?
A:
[1-246]
----
M
A
R
I
G
I
H
S
F
V
W
S
A
S
S
-----
A
Q
S
E
L
E
R
T
L
-----
A
N
T
R
D
A
G
F
D
L
I
E
F
S
Y
----
L
---------
D
----------
P
ADV------
D
I
G
R
--------
L
A
K
R
I
A
D
L
G
L
G
V
A
I
S
----------------
I
G
L
---
P
AD
G
-------
D
-------------
I
----------------------
S
--
S
--
A
--
D
K
A
V
A
A
---------
R
G
V
E
I
L
N
Q
T
I
A
L
T
R
D
L
G
G
R
-
K
V
-
A
G
I
L
-
S
A
-
G
H
---
G
---------
L
Q
-
V
E
A
P
-
T
R
D
Q
W
N
R
S
A
A
A
L
A
K
V
A
E
T
A
K
A
A
G
V
T
L
N
L
E
I
V
N
-----
R
FES-----
N
---
L
L
N
T
----------
A
A
Q
G
-
L
A
F
I
E
D
T
-
G
S
-
D
N
I
F
L
H
L
D
T
F
H
M
N
I
E
E
-
A
D
--
V
G
L
A
I
R
H
A
A
G
--
K
I
G
Y
V
H
I
G
E
S
H
R
--------------------------
G
F
L
G
T
G
N
I
-
D
F
A
A
I
F
D
-
A
L
T
A
I
G
Y
A
D
D
-
L
-
S
F
E
S
F
S
S
E
--------------------------------------------------------------
43
HHSearch
47.55
18%
2
- C3 -
2ZVR
-
Y416_THEMA
A:
[1-266]
-----
M
K
L
S
L
V
I
S
T
S
D
--------
F
K
G
D
L
R
K
G
M
-----
E
L
A
K
R
V
G
Y
Q
A
V
E
I
A
V
----
R
---------
D
----------
P
SIV------
D
W
N
E
--------
V
K
I
L
S
E
E
L
N
L
P
I
C
-
A
----------------
I
G
T
---
G
--
Q
A
Y
L
A
DGL
S
-------------
L
----------------------
T
--
H
--
P
--
N
D
E
I
R
K
---------
K
A
I
E
R
V
V
K
H
T
E
V
A
G
M
F
G
A
L
-
V
I
-
I
--
G
-
L
V
-
R
G
R
------------
R
E
--
G
R
S
-
Y
E
E
T
E
E
L
F
I
E
S
M
K
R
L
L
E
L
T
E
H
--
A
K
F
V
I
E
P
L
N
-----
R
YET-----
D
---
F
I
N
T
----------
I
D
D
A
-
L
R
I
L
R
K
I
-
N
S
-
N
R
V
G
I
L
A
D
T
F
H
M
N
I
E
E
-
V
N
--
I
P
E
S
L
K
R
A
G
E
--
K
L
Y
H
F
H
V
A
D
S
N
R
--------------------------
W
A
P
G
C
G
H
F
-
D
F
R
S
V
F
N
-
T
L
K
E
I
G
Y
N
R
Y
-
V
-
S
V
E
C
L
P
L
P
G
-------------------------------------
G
--
M
E
E
A
A
E
I
A
F
K
T
L
K
E
L
I
-----
48
HHSearch
47.52
18%
3
- C3 -
3WQO
2
Y1311_METJA
A:
[16-264]
----
D
M
K
F
G
V
S
S
L
V
F
L
---------
P
E
S
L
T
S
S
M
-----
E
K
I
A
E
H
N
F
D
A
W
E
I
V
C
----
E
---------
G
THYL------
S
P
K
-------
N
I
K
Y
--------
L
M
E
L
R
D
R
Y
E
V
E
I
V
-
V
----------------
H
A
P
---
F
SD
L
-------
N
-------------
P
----------------------
A
--
S
--
M
--
N
E
R
V
R
K
---------
L
T
V
E
C
I
R
D
A
I
E
G
A
F
E
L
D
S
E
-
V
V
-
V
--
V
-
H
P
-
G
Y
I
P
-----------
E
L
-
W
S
N
Y
-
V
S
E
I
L
D
N
N
F
S
T
L
S
E
I
V
E
I
A
E
D
Y
G
I
K
I
G
L
E
N
M
P
-----
N
FRG-----
V
---
L
G
I
T
----------
P
E
S
L
-
L
E
I
V
K
D
I
-
D
S
-
K
N
L
G
I
T
F
D
I
G
H
A
N
T
A
G
-
N
P
AE
F
V
E
K
L
Q
N
I
G
I
--
G
I
I
H
V
H
A
H
D
N
N
G
Y
--
D
-------------------
D
E
H
L
K
I
G
E
G
N
I
-
N
F
I
E
V
L
E
-
K
L
K
E
I
G
Y
D
G
V
-
I
-
S
I
E
N
K
N
I
---------------------------------------------------------------
36
HHSearch
46.25
13%
-22
- C3 -
3QC0
12
?
A:
[2-274]
--
M
Q
V
E
G
L
S
I
N
L
A
T
I
R
--------
E
Q
C
G
F
A
E
A
V
-----
D
I
C
L
K
H
G
I
T
A
I
A
P
W
R
----
D
Q
--------
V
----------
A
A
I
-------
G
L
G
E
--------
A
G
R
I
V
R
A
N
G
L
K
L
T
-
G
----------------
L
C
R
---
G
--
G
-------
F
-------------
F
----------------------
P
--
A
--
P
--
D
A
S
G
R
E
---------
K
A
I
D
D
N
R
R
A
V
D
E
A
A
E
L
G
A
D
-
C
L
-
V
--
L
-
V
A
-
G
G
L
------------
P
G
-
G
S
K
N
-
I
D
A
A
R
R
M
V
V
E
G
I
A
A
V
L
P
H
A
R
A
A
G
V
P
L
A
I
E
P
L
H
-----
P
MYAADR--
A
---
C
V
N
T
----------
L
G
Q
A
-
L
D
I
C
E
T
L
-
G
--
P
G
V
G
V
A
I
D
V
Y
H
V
W
W
D
P
--
D
--
L
A
N
Q
I
A
R
A
G
K
M
K
A
I
L
A
H
H
I
C
D
W
L
V
P
--
T
K
D
---------------
M
L
T
D
R
G
M
M
G
D
G
V
I
-
D
L
K
G
I
R
R
-
R
I
E
A
A
G
F
H
G
A
-
Q
-
E
V
E
I
F
S
A
D
N
W
W
K-----------------
R
----------------
P
--
A
D
E
V
I
A
T
C
V
E
R
Y
R
N
C
------
49
HHSearch
45.66
16%
7
- C3 -
3OBE
7
?
A:
[19-303]
---
A
G
K
K
M
G
L
Q
T
Y
S
L
G
Q
E
L
------
L
Q
D
M
P
N
G
L
-----
N
R
L
A
K
A
G
Y
T
D
L
E
I
F
G
----
Y
REDTG
K
F
G
D
Y
-----------T
T
F
I
-----
A
S
K
D
--------
Y
K
K
M
V
D
D
A
G
L
R
I
S
-
S
----------------
S
H
L
---
T
--
P
-------
S
-------------
L
----------------------
R
--
E
--
Y
--
T
KEN
M
P
---------
K
F
D
E
F
W
K
K
A
T
D
I
H
A
E
L
G
V
S
-
C
M
-
V
--
Q
-
P
S
-
L
P
-----------------
R
I
E
-
N
E
D
D
A
K
V
V
S
E
I
F
N
R
A
G
E
I
T
K
K
A
G
I
L
W
G
Y
H
N
H
S
-----
N
--------
E
---
F
K
R
V
L
K
AGEKPEP
K
G
T
Y
I
E
E
L
F
L
K
N
T
-
D
P
-
D
K
V
M
F
E
L
D
V
Y
W
A
V
M
G
Q
-
Q
D
--
P
V
E
W
M
E
N
Y
P
N
--
R
F
K
L
L
H
I
K
D
R
W
I
---------------------------
I
G
D
S
G
M
M
-
N
F
P
N
I
F
K
-
K
A
Y
E
I
G
I
L
G
Y
-
Y
V
E
L
E
G
D
K
K
G
R
-------------------------------------
T
--
Q
F
E
G
V
E
K
S
A
A
Y
L
Q
A
A
P
F
----
46
HHSearch
44.48
14%
14
- C3 -
2G0W
1
?
A:
[35-289]
-------------------------
E
V
S
F
P
K
R
V
-----
K
V
A
A
E
N
G
F
D
G
I
G
L
R
A
----
E
---------
N
Y
V
D
A
L
-----
A
A
GL------
T
D
E
D
--------
M
L
R
I
L
D
E
H
N
M
K
V
T
-
E
----------------
V
E
Y
---
I
--
T
-------
Q
-------------
W
----------------------
G
--
T
--
A
E-
D
R--
T
A
---------
E
Q
Q
K
K
E
Q
T
T
F
H
M
A
R
L
F
G
V
K
-
H
I
-
N
--
C
-
G
L
-
L
------------------
E
----
K
I
P
E
E
Q
I
I
V
A
L
G
E
L
C
D
R
A
E
E
L
I
--
I
G
L
E
F
M
P
-----
Y
--------
S
---
G
V
A
D
----------
L
Q
A
A
-
W
R
V
A
E
A
C
-
G
R
-
D
N
A
Q
L
I
C
D
T
W
H
W
A
R
A
N
-
Q
T
--
A
E
S
I
K
N
V
P
A
D
--
R
I
V
S
I
Q
L
C
D
V
H
E
T
--
P
Y
K
--
E
L
R
--------
E
E
S
L
H
D
R
L
A
P
G
E
G
Y
G
-
D
T
V
G
F
A
K
-
I
L
K
E
H
G
V
N
P
R
V
M
-
G
V
E
V
I
S
D
S
M
-
V
------------------
A
T
---------------
G
--
L
E
Y
A
A
L
K
V
Y
N
A
T
K
K
V
L
D
E
A
--