@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu39820: (2016-08-06 )
MAKKEFKAESKRLLDMMINSIYTQKEIFLRELISNSSDAIDKIYYKALTDDALTFDKDSYYIKVAADKDARTLTISDTGIGMTKDELEQHLGTIAKSGSLAFKKENELKDGHDIIGQFGVGFYAAFMVADVVTVISKALGSEEAYKWESAGADGYTIEPCEKDSVGTDIILKIKENTEDDSYDEFLEEYRLKAIIKKYSDFIRYPIKMDTTINKPKEGSENEFEEVQEEQTVNSMVPIWRKNKSELTDEDYEKFYAEKHYGFDKPLTHVHISVDGAVRYNAILFVPENMPFDYYSKEYEKGLELYSNGVLIMNKCADLLPDHFSFVKGMVDSEDLSLNISREMLQHDRQLKLIAKNISKKIKSELQSLLKKDREKYETFYKSFGRQLKFGVYNDFGANKDQLKDLLLFYSSKEKKLVSLDEYVSRMPEEQKFIYYATGDSYDRIEKLPQTEMVADKGYEILYFTEDIDEFAIKMLASYQEKEFKSVSSGDLGIDTDEDQKQSEEEESKYKDLFEEMKNILSDKVKNVRISKRLKSHPVCLAADGEVTIEMEKILNAMPDSQNVKAEKVLEINPNHEVFQTLQDAFEQDKEKLSLYTNLLYNQALLIEGLPIQDPVEFTNNICKVMV
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100--...---....110..--.....120.......130.....-..140..--.......150.......160-..-..--....170.......180.......190.......200.......210....-...220.......230.......240.......250.......260.......270.......280.......290....-.....300.......310.......320.......330.......340.......350.......360.......370....-...380.......390......-.400.......410--.---.-..-....420.......430.......440.......450.......460.......470.......480.......490..-----....-.500...-..--.-.510......-.520.......530.......540..-.-.--...550......------.560-----.-.--------...---..-..570.......580----.....--.---.--590.........600.......610.......620....-----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MA
K
K
E
F
K
A
E
S
K
R
L
L
D
M
M
I
N
S
I
Y
T
Q
K
E
I
F
L
R
E
L
ISNSS
D
A
I
D
K
I
Y
Y
K
ALTDDA
L
T
FDKD
S
Y
Y
I
K
V
AADKDA
R
T
L
T
I
SDTGIGM
T
K
D
E
L
E
Q
H
L
G
T
I
AKSG
S
L
A
F
--KKE---NELK
D
G
H
D
I
--
I
G
Q
F
G
V
G
F
Y
A
A
F
M
V
A
D
V
V
T
V
I
S
K
-ALG--S
E
--
E
A
Y
KWESAGADG
Y
T
IEPCE--KD-SV--G
T
D
I
I
L
K
IKENTEDD
S
Y
D
E
F
L
E
E
Y
R
L
K
A
I
I
K
K
Y
S
D
F
IRYPIKMDTTINKPK-EGS
E
N
E
F
E
E
V
Q
E
E
Q
T
V
N
S
MV
P
I
WRKNKSEL
T
D
E
D
Y
E
K
F
Y
A
E
KHYGFDKP
L
T
H
V
H
I
S
VDG
A
V
R
Y
N
A
I
L
F
VPENM
P
--
F
D
Y
Y
-
S
K
E
Y
E
K
G
L
E
L
YSN
G
V
L
I
M
N
K
C
A
D
L
L
P
D
H
F
S
F
V
K
GMVDSED
L
S
L
N
I
S
R
E
M
L
Q
H
D
R
Q
L
K
L
I
A
K
N
I
S
K
K
I
K
S
E
L
Q
S
L
L
K
K
D
R
E
K
Y
-
E
T
F
Y
K
S
FGR
Q
L
K
F
G
V
YNDFGA
N
-
K
D
Q
L
K
D
L
L
L
F
YSS---K---E-
K
K
-
L
V
S
L
D
E
Y
V
S
RMPEEQ
K
F
I
Y
Y
ATGD
S
Y
D
R
I
E
KLPQTEMVADKG
Y
E
I
L
Y
F
TE
D
I
D
E
F
A
I
K
M
L
A
S
Y
Q
E
K
E
F
KSVSSGDLGID-----TD
E
D
-
Q
K
Q
S
E
E
E
-
E
S
--
K
-
Y
K
D
L
F
E
E
M
K
N
-
I
L
S
D
K
V
K
N
V
R
I
S
K
R
LKSHP
V
C
L
AAD
G
-
E
-
V
--
T
I
E
M
E
K
I
L
N
AMP------DS-------Q-N--------VK
A
---
E
K
-
V
L
E
INP
N
H
E
V
F
Q
T
L
Q
----
D
A
F
E
Q
--
D
---
K
--
E
--
K
L
S
L
Y
T
N
L
LYN
Q
A
L
L
IEGLPIQ
D
P
V
E
F
T
N
N
I
C
K
VMV-----
1
PsiBlast_PDB
77.06
39%
35
- C2 -
2IOQ
-
HTPG_ECOLI
A:
[15-623]
-----------
Q
L
L
H
L
M
I
H
S
L
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
A
D
K
L
R
F
R
A
L
S
N
P
D
L
Y
E
G
D
G
E
L
R
V
R
V
S
F
D
K
D
K
R
T
L
T
I
S
D
N
G
V
G
M
T
R
D
E
V
I
D
H
L
G
T
I
A
K
-----------------
K
D
S
Q
-
L
--
I
G
Q
F
G
V
G
F
Y
S
A
F
I
V
A
D
K
V
T
V
R
T
R
-
A
A
G
EK
P
E
--
N
G
V
F
W
E
S
A
G
E
G
E
Y
T
V
A
D
I
T
--
K
E
-
D
R
--
G
T
E
I
T
L
H
L
R
E
G
E
-----
D
E
F
L
D
D
W
R
V
R
S
I
I
S
K
Y
S
D
H
I
A
L
P
V
E
I
E
--------
K
R
E
E
K
D
G
E
T
V
I
S
W
E
K
I
N
K
A
Q
A
L
W
T
R
N
K
S
E
I
T
D
E
E
Y
K
E
F
Y
K
H
I
A
H
D
F
N
D
P
L
T
W
S
H
N
R
V
E
G
K
Q
E
Y
T
S
L
L
Y
I
P
S
Q
A
P
--
W
D
M
W
-
N
R
D
H
K
H
G
L
K
L
Y
V
Q
R
V
F
I
M
D
D
A
E
Q
F
M
P
N
Y
L
R
F
V
R
G
L
I
D
S
S
D
L
P
L
N
V
S
R
E
I
L
Q
D
S
T
V
T
R
N
L
R
N
A
L
T
K
R
V
L
Q
M
L
E
K
L
A
K
D
D
A
E
K
Y
-
Q
T
F
W
Q
Q
F
G
L
V
L
K
E
G
P
A
E
D
F
-
A
N
-
Q
E
A
I
A
K
L
L
R
F
A
S
T
HTD
S
---
S
-
A
Q
-
T
V
S
L
E
D
Y
V
S
R
M
K
E
G
Q
E
K
I
Y
Y
I
T
A
D
S
Y
A
A
A
K
S
S
P
H
L
E
L
L
R
K
K
G
I
E
V
L
L
L
S
D
R
I
D
E
W
M
M
N
Y
L
T
E
F
D
G
K
P
F
Q
S
V
S
K
V
D
E
S
L
E
KL---
A
--------
K
E
A
-
E
K
--
A
-
L
T
P
F
I
D
R
V
K
A
-
L
L
G
E
R
V
K
D
V
R
L
T
H
R
L
T
D
T
P
A
I
V
S
T
D
A
---------------------------------------------------
K
Y
I
F
E
L
N
P
D
H
V
L
V
K
R
A
A
----
D
T
--
E
--
D
---
E
--
A
--
K
F
S
E
W
V
E
L
L
L
D
Q
A
L
L
A
E
R
G
T
L
E
D
P
N
L
F
I
R
R
M
N
Q
L
L
V
-----
112
HHSearch
76.26
39%
43
- C2 -
2IOQ
-
HTPG_ECOLI
A:
[15-623]
-----------
Q
L
L
H
L
M
I
H
S
L
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
A
D
K
L
R
F
R
A
L
S
N
P
D
L
Y
E
G
D
G
E
L
R
V
R
V
S
F
D
K
D
K
R
T
L
T
I
S
D
N
G
V
G
M
T
R
D
E
V
I
D
H
L
G
T
I
A
K
------------------
K
D
S
Q
L
--
I
G
Q
F
G
V
G
F
Y
S
A
F
I
V
A
D
K
V
T
V
R
T
R
-
A
A
G
--
E
K
PE
N
G
V
F
W
E
S
A
G
E
G
E
Y
T
V
A
D
I
T
--
K
E
-
D
R
--
G
T
E
I
T
L
H
L
R
E
----
G
E
D
-
E
F
L
D
D
W
R
V
R
S
I
I
S
K
Y
S
D
H
I
A
L
P
V
E
I
E
K
R
E
E
K
--------
D
G
E
T
V
I
S
W
E
K
I
N
K
A
Q
A
L
W
T
R
N
K
S
E
I
T
D
E
E
Y
K
E
F
Y
K
H
I
A
H
D
F
N
D
P
L
T
W
S
H
N
R
V
E
G
K
Q
E
Y
T
S
L
L
Y
I
P
S
Q
A
P
--
W
D
M
W
-
N
R
D
H
K
H
G
L
K
L
Y
V
Q
R
V
F
I
M
D
D
A
E
Q
F
M
P
N
Y
L
R
F
V
R
G
L
I
D
S
S
D
L
P
L
N
V
S
R
E
I
L
Q
D
S
T
V
T
R
N
L
R
N
A
L
T
K
R
V
L
Q
M
L
E
K
L
A
K
D
D
A
E
K
Y
-
Q
T
F
W
Q
Q
F
G
L
V
L
K
E
G
P
A
E
D
F
-
A
N
-
Q
E
A
I
A
K
L
L
R
F
A
S
T
---
H
TDS
S
-
A
Q
-
T
V
S
L
E
D
Y
V
S
R
M
K
E
G
Q
E
K
I
Y
Y
I
T
A
D
S
Y
A
A
A
K
S
S
P
H
L
E
L
L
R
K
K
G
I
E
V
L
L
L
S
D
R
I
D
E
W
M
M
N
Y
L
T
E
F
D
G
K
P
F
Q
S
V
S
K
V
D
E
S
L
E
-----
K
L
A
------
K
E
A
-
E
K
--
A
-
L
T
P
F
I
D
R
V
K
A
-
L
L
G
E
R
V
K
D
V
R
L
T
H
R
L
T
D
T
P
A
I
V
S
T
D
A
--------------------------------------------------
K
Y
-
I
F
E
L
N
P
D
H
V
L
V
K
R
A
A
----
D
T
E
----
D
---
E
--
A
--
K
F
S
E
W
V
E
L
L
L
D
Q
A
L
L
A
E
R
G
T
L
E
D
P
N
L
F
I
R
R
M
N
Q
L
L
V
-----
113
HHSearch
75.96
36%
23
- C2 -
2O1U
3
?
A:
[34-656]
------------
M
M
K
L
I
I
N
S
L
Y
K
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
L
I
S
L
T
D
E
N
A
L
A
G
N
E
E
L
T
V
K
I
K
C
D
K
E
K
N
L
L
H
V
T
D
T
G
V
G
M
T
R
E
E
L
V
K
N
L
G
T
---------------------------------
V
G
F
Y
S
A
F
L
V
A
D
K
V
I
V
T
S
K
-
H
N
N
--
D
---
T
Q
H
I
W
E
S
D
S
-
N
E
F
S
V
I
A
D
P
RG
N
T
L
G
R
--
G
T
T
I
T
L
V
L
K
E
----
E
A
S
-
D
Y
L
E
L
D
T
I
K
N
L
V
K
K
Y
S
Q
F
I
N
F
P
I
Y
V
W
S
S
K
--------------
V
W
D
W
E
L
M
N
D
I
K
P
I
W
Q
R
P
S
K
E
V
E
D
D
E
Y
K
A
F
Y
K
S
F
S
K
E
S
D
D
P
M
A
Y
I
H
F
T
A
E
G
E
V
T
F
K
S
I
L
F
V
P
T
S
A
P
--
R
----------
Y
I
K
L
Y
V
R
R
V
F
I
T
D
D
F
H
D
M
M
P
K
Y
L
N
F
V
K
G
V
V
D
S
D
D
L
P
L
N
V
S
R
E
T
L
Q
Q
H
K
L
L
K
V
I
R
K
K
L
V
R
K
T
L
D
M
I
K
K
I
A
D
---
E
K
Y
N
D
T
F
W
K
E
F
G
T
N
I
K
L
G
V
I
E
D
H
-
S
N
-
R
T
R
L
A
K
L
L
R
F
Q
S
S
---
H
H--
P
-
S
D
-
I
T
S
L
D
Q
Y
V
E
R
M
K
E
K
Q
D
K
I
Y
F
M
A
G
S
S
R
K
E
A
E
S
S
P
F
V
E
R
L
L
K
K
G
Y
E
V
I
Y
L
T
E
P
V
D
E
Y
C
I
Q
A
L
P
E
F
D
G
K
R
F
Q
N
V
A
K
E
G
V
K
F
D
-----
E
S
E
K
T
K
E
S
R
E
A
I
-
E
K
--
E
-
F
E
P
L
L
N
W
M
K
D
K
A
L
K
D
K
I
E
K
A
V
V
S
Q
R
L
T
E
S
P
C
A
L
V
A
S
Q
Y
G
-
W
--
S
G
N
M
E
R
I
M
K
A
Q
A
------
Y
Q
TGKDIST
N
Y
Y
--------
A
S
Q
---
K
K
-
T
F
E
I
N
P
R
H
P
L
I
K
D
M
L
----
R
R
V
K
E
DE
D
---
D
--
K
--
T
V
S
D
L
A
V
V
L
F
E
T
A
T
L
R
S
G
Y
L
L
P
D
T
K
A
Y
G
D
R
I
E
R
M
L
R
-----
24
PsiBlast_CBE
75.92
36%
27
- C2 -
2O1V
3
ENPL_CANLF
B:
[36-655]
--------------
K
L
I
I
N
S
L
Y
K
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
L
I
S
L
T
D
E
N
A
L
A
G
N
E
E
L
T
V
K
I
K
C
D
K
E
K
N
L
L
H
V
T
D
T
G
V
G
M
T
R
E
E
L
V
K
N
L
G
T
---------------------------------
V
G
F
Y
S
A
F
L
V
A
D
K
V
I
V
T
S
K
-
H
-
N
--
N
D
--
T
Q
H
I
W
E
S
D
S
N
E
F
S
V
I
A
D
P
R
--
G
N
-
T
L
G
R
G
T
T
I
T
L
V
L
K
E
E
A
S
D
-----
Y
L
E
L
D
T
I
K
N
L
V
K
K
Y
S
Q
F
I
N
F
P
I
Y
V
W
S
S
----
K
-
T
--------
V
W
D
W
E
L
M
N
D
I
K
P
I
W
Q
R
P
S
K
E
V
E
D
D
E
Y
K
A
F
Y
K
S
F
S
K
E
S
D
D
P
M
A
Y
I
H
F
T
A
E
G
E
V
T
F
K
S
I
L
F
V
P
T
S
A
--------------
Y
I
K
L
Y
V
R
R
V
F
I
T
D
D
F
H
D
M
M
P
K
Y
L
N
F
V
K
G
V
V
D
S
D
D
L
P
L
N
V
S
R
E
T
L
Q
Q
H
K
L
L
K
V
I
R
K
K
L
V
R
K
T
---
L
D
M
I
K
K
I
A
D
E
K
Y
N
D
T
F
W
K
E
F
G
T
N
I
K
L
G
V
I
E
D
H
-
S
N
-
R
T
R
L
A
K
L
L
R
F
Q
S
S
---
H
---
H
-
P
S
D
I
T
S
L
D
Q
Y
V
E
R
M
K
E
K
Q
D
K
I
Y
F
M
A
G
S
S
R
K
E
A
E
S
S
P
F
V
E
R
L
L
K
K
G
Y
E
V
I
Y
L
T
E
P
V
D
E
Y
C
I
Q
A
L
P
E
F
D
G
K
R
F
Q
N
V
A
K
E
G
V
K
F
D
-----
E
S
E
K
-
T
K
E
S
R
E
A
I
E
K
--
E
-
F
E
P
L
L
N
W
M
K
D
K
A
L
K
D
K
I
E
K
A
V
V
S
Q
R
L
T
E
S
P
C
A
L
V
A
S
Q
Y
G
-
W
--
S
G
N
M
E
R
I
M
K
A
Q
A
Y
Q
TGKD
I
S
-------
T
-
N
--------
Y
Y
A
SQ-
K
K
-
T
F
E
I
N
P
R
H
P
L
I
K
D
M
L
----
R
R
V
K
E
--
D
---
E
--
D
D
K
T
V
S
D
L
A
V
V
L
F
E
T
A
T
L
R
S
G
Y
L
L
P
D
T
K
A
Y
G
D
R
I
E
R
M
L
------
6
PsiBlast_PDB
75.86
36%
30
- C2 -
2O1V
3
ENPL_CANLF
A:
[34-655]
------------
M
M
K
L
I
I
N
S
L
Y
K
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
L
I
S
L
T
D
E
N
A
L
A
G
N
E
E
L
T
V
K
I
K
C
D
K
E
K
N
L
L
H
V
T
D
T
G
V
G
M
T
R
E
E
L
V
K
N
L
G
T
---------------------------------
V
G
F
Y
S
A
F
L
V
A
D
K
V
I
V
T
S
K
-
H
-
N
--
N
D
--
T
Q
H
I
W
E
S
D
S
N
E
F
S
V
I
A
D
P
R
--
G
N
-
T
L
G
R
G
T
T
I
T
L
V
L
K
E
E
A
S
D
-----
Y
L
E
L
D
T
I
K
N
L
V
K
K
Y
S
Q
F
I
N
F
P
I
Y
V
W
S
S
----
K
----------
V
W
D
W
E
L
M
N
D
I
K
P
I
W
Q
R
P
S
K
E
V
E
D
D
E
Y
K
A
F
Y
K
S
F
S
K
E
S
D
D
P
M
A
Y
I
H
F
T
A
E
G
E
V
T
F
K
S
I
L
F
V
P
T
S
A
P
R------------
Y
I
K
L
Y
V
R
R
V
F
I
T
D
D
F
H
D
M
M
P
K
Y
L
N
F
V
K
G
V
V
D
S
D
D
L
P
L
N
V
S
R
E
T
L
Q
Q
H
K
L
L
K
V
I
R
K
K
L
V
R
K
T
---
L
D
M
I
K
K
I
A
D
E
K
Y
N
D
T
F
W
K
E
F
G
T
N
I
K
L
G
V
I
E
D
H
-
S
N
-
R
T
R
L
A
K
L
L
R
F
Q
S
S
---
H
---
H
-
P
S
D
I
T
S
L
D
Q
Y
V
E
R
M
K
E
K
Q
D
K
I
Y
F
M
A
G
S
S
R
K
E
A
E
S
S
P
F
V
E
R
L
L
K
K
G
Y
E
V
I
Y
L
T
E
P
V
D
E
Y
C
I
Q
A
L
P
E
F
D
G
K
R
F
Q
N
V
A
K
E
G
V
K
F
D
-----
E
S
E
K
-
T
K
E
S
R
E
A
I
E
K
--
E
-
F
E
P
L
L
N
W
M
K
D
K
A
L
K
D
K
I
E
K
A
V
V
S
Q
R
L
T
E
S
P
C
A
L
V
A
S
Q
Y
G
-
W
--
S
G
N
M
E
R
I
M
K
A
Q
A
Y
Q
TGKD
I
S
-------
T
-
N
--------
Y
Y
A
S
Q
-
K
K
-
T
F
E
I
N
P
R
H
P
L
I
K
D
M
L
----
R
R
V
K
E
--
D
---
E
--
D
D
K
T
V
S
D
L
A
V
V
L
F
E
T
A
T
L
R
S
G
Y
L
L
P
D
T
K
A
Y
G
D
R
I
E
R
M
L
------
101
Fugue
75.66
36%
24
- C2 -
2O1U
3
?
A:
[34-661]
------------
M
M
K
L
I
I
N
S
L
Y
K
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
L
I
S
L
T
D
E
N
A
L
A
G
N
E
E
L
T
V
K
I
K
C
D
K
E
K
N
L
L
H
V
T
D
T
G
V
G
M
T
R
E
E
L
V
K
N
L
G
T
---------------------------------
V
G
F
Y
S
A
F
L
V
A
D
K
V
I
V
T
S
K
-
H
N
N
--
D
T
---
Q
H
I
W
E
S
D
S
N
E
F
S
V
I
A
D
P
R
--
G
N
-
T
L
G
R
G
T
T
I
T
L
V
L
K
E
E
A
-----
S
D
Y
L
E
L
D
T
I
K
N
L
V
K
K
Y
S
Q
F
I
N
F
P
I
Y
V
W
S
--------------
S
K
V
W
D
W
E
L
M
N
D
I
K
P
I
W
Q
R
P
S
K
E
V
E
D
D
E
Y
K
A
F
Y
K
S
F
S
K
E
S
D
D
P
M
A
Y
I
H
F
T
A
E
G
E
V
T
F
K
S
I
L
F
V
P
T
S
A
P
--
R
----------
Y
I
K
L
Y
V
R
R
V
F
I
T
D
D
F
H
D
M
M
P
K
Y
L
N
F
V
K
G
V
V
D
S
D
D
L
P
L
N
V
S
R
E
T
L
Q
Q
H
K
L
L
K
V
I
R
K
K
L
V
R
K
T
L
D
M
I
K
K
I
--
A
D
E
K
Y
N
-
D
T
F
W
K
E
F
G
T
N
I
K
L
G
V
I
E
D
-
H
S
N
-
R
T
R
L
A
K
L
L
R
F
Q
S
S
---
H
H--
P
-
S
D
-
I
T
S
L
D
Q
Y
V
E
R
M
K
E
K
Q
D
K
I
Y
F
M
A
G
S
S
R
K
E
A
E
S
S
P
F
V
E
R
L
L
K
K
G
Y
E
V
I
Y
L
T
E
P
V
D
E
Y
C
I
Q
A
L
P
E
F
D
G
K
R
F
Q
N
V
A
K
E
G
V
K
F
D
-----
E
S
E
K
-
T
K
E
S
R
E
A
-
I
E
--
K
E
F
E
P
L
L
N
W
M
K
D
K
A
L
K
D
K
I
E
K
A
V
V
S
Q
R
L
T
E
S
P
C
A
L
V
A
S
Q
-
Y
G
W
--
S
G
N
M
E
R
I
M
K
A
Q
A
------
Y
Q
-------
T
-
G
KDISTNYY
A
S
Q
---
K
K
-
T
F
E
I
N
P
R
H
P
L
I
K
D
M
L
----
R
R
V
K
E
--
D
---
E
DD
K
--
T
V
S
D
L
A
V
V
L
F
E
T
A
T
L
R
S
G
Y
L
L
P
D
T
K
A
Y
G
D
R
I
E
R
M
L
R
L
S
LNI
8
PsiBlast_PDB
75.57
31%
15
- C3 -
4J0B
4
?
A:
[29-641]
-
S
K
H
E
F
Q
A
E
T
K
K
L
L
D
I
V
A
R
S
L
Y
S
E
K
E
V
F
I
R
E
L
I
S
N
G
S
D
A
L
E
K
L
R
H
R
M
I
T
A
G
G
---
D
T
A
P
M
E
I
H
L
Q
T
D
S
V
K
G
T
F
T
I
Q
D
T
G
V
G
M
N
K
E
D
L
V
S
N
L
G
T
I
A
R
S
G
S
K
A
F
L
D
A
L
Q
---
N
Q
A
E
A
S
S
S
I
--
I
G
Q
F
G
V
G
F
Y
S
A
F
M
V
A
D
K
V
E
V
Y
S
Q
S
A
E
A
--
D
A
--
P
G
Y
K
W
S
S
D
G
S
G
V
F
E
V
A
E
A
S
--
G
V
-
R
Q
--
G
T
K
I
V
L
H
L
K
-----
D
D
C
K
E
F
S
S
E
D
R
V
K
E
V
V
T
K
Y
S
N
F
V
S
F
P
I
F
L
N
G
--------------------
R
R
L
N
T
L
Q
A
L
W
M
M
E
P
K
D
I
S
E
W
Q
H
E
E
F
Y
R
Y
V
A
Q
A
Y
D
K
P
R
Y
T
L
H
Y
R
A
D
A
P
L
N
I
R
S
I
F
Y
V
P
E
M
K
P
----------
M
G
S
S
V
A
L
Y
S
R
K
I
L
I
Q
T
K
A
T
D
I
L
P
K
W
L
R
F
L
R
G
V
V
D
S
E
D
I
P
L
N
L
S
R
E
L
L
Q
E
S
A
L
I
R
K
L
R
D
V
L
Q
Q
R
V
I
R
F
L
L
D
Q
S
K
K
D
P
E
K
Y
-
A
R
F
F
E
D
Y
G
L
F
M
R
E
G
I
V
T
T
G
E
Q
S
V
K
E
D
I
A
K
L
L
R
F
E
S
S
AL-
P
---
A
-
G
Q
-
Q
T
S
L
M
E
Y
S
S
R
M
K
A
G
T
R
N
I
Y
Y
L
C
A
P
N
R
H
L
A
E
H
S
P
Y
F
E
A
M
K
--
D
M
E
V
L
F
C
F
E
Q
F
D
E
L
T
L
L
H
L
R
E
F
D
R
K
K
L
I
S
A
E
T
----------------------
R
-
L
S
S
E
Q
-
A
E
D
L
L
A
W
M
R
N
-
A
L
V
Q
R
V
T
N
I
K
V
T
P
R
L
D
T
H
P
A
M
I
-------
T
--
V
L
E
M
G
A
A
R
H
F
L
R
------
T
Q
---------------------QI
L
Q
P
-
T
L
E
I
N
T
G
H
D
L
I
K
K
L
H
----
A
L
K
D
S
--
N
---
P
--
E
--
L
A
Q
L
L
L
E
Q
I
Y
D
N
A
M
I
A
A
G
L
N
-
E
D
P
R
P
M
I
S
R
L
N
Q
L
L
T
-----
111
HHSearch
75.30
39%
15
- C3 -
2CG9
1
HSP82_YEAST
A:
[3-673]
S
E
T
F
E
F
Q
A
E
I
T
Q
L
M
S
L
I
I
N
T
V
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
Y
K
S
L
S
D
P
K
Q
L
E
T
E
P
D
L
F
I
R
I
T
P
K
P
E
Q
K
V
L
E
I
R
D
S
G
I
G
M
T
K
A
E
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
--
M
E
A
---
L
S
A
G
A
D
V
S
M
--
I
G
Q
F
G
V
G
F
Y
S
L
F
L
V
A
D
R
V
Q
V
I
S
K
-
S
N
D
--
D
---
E
Q
Y
I
W
E
S
N
A
G
G
S
F
T
V
T
L
D
E
VN
E
R
I
G
R
--
G
T
I
L
R
L
F
L
K
D
----
D
Q
L
-
E
Y
L
E
E
K
R
I
K
E
V
I
K
R
H
S
E
F
V
A
Y
P
I
Q
L
V
V
T
K
E
V
E
K
E-------
E
E
V
Q
E
I
E
E
L
N
K
T
K
P
L
W
T
R
N
P
S
D
I
T
Q
E
E
Y
N
A
F
Y
K
S
I
S
N
D
W
E
D
P
L
Y
V
K
H
F
S
V
E
G
Q
L
E
F
R
A
I
L
F
I
P
K
R
A
P
--
F
---------
N
N
I
K
L
Y
V
R
R
V
F
I
T
D
E
A
E
D
L
I
P
E
W
L
S
F
V
K
G
V
V
D
S
E
D
L
P
L
N
L
S
R
E
M
L
Q
Q
N
K
I
M
K
V
I
R
K
N
I
V
K
K
L
I
E
A
F
N
E
I
A
E
-
D
S
E
Q
F
-
E
K
F
Y
S
A
F
S
K
N
I
K
L
G
V
H
E
D
T
-
Q
N
-
R
A
A
L
A
K
L
L
R
Y
N
S
T
---
K
S--
V
-
D
E
-
L
T
S
L
T
D
Y
V
T
R
M
P
E
H
Q
K
N
I
Y
Y
I
T
G
E
S
L
K
A
V
E
K
S
P
F
L
D
A
L
K
A
K
N
F
E
V
L
F
L
T
D
P
I
D
E
Y
A
F
T
Q
L
K
E
F
E
G
K
T
L
V
D
I
T
K
D
-
F
E
L
E
-----
E
T
D
E
E
K
A
E
R
E
K
E
-
I
K
--
E
-
Y
E
P
L
T
K
A
L
K
E
-
I
L
G
D
Q
V
E
K
V
V
V
S
Y
K
L
L
D
A
P
A
A
I
R
T
G
Q
F
G
-
W
--
S
A
N
M
E
R
I
M
K
A
Q
A
---------------------------------
K
-
T
F
E
I
S
P
K
S
P
I
I
K
E
L
K
----
K
R
V
D
E
--
G
GAQ
D
--
K
--
T
V
K
D
L
T
K
L
L
Y
E
T
A
L
L
T
S
G
F
S
L
D
E
P
T
S
F
A
S
R
I
N
R
L
I
S
-----
21
PsiBlast_CBE
75.17
39%
46
- C2 -
2IOP
1
HTPG_ECOLI
D:
[7-623]
---
R
G
F
Q
S
E
V
K
Q
L
L
H
L
M
I
H
S
L
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
A
D
K
L
R
F
R
A
L
S
N
P
D
L
Y
E
G
D
G
E
L
R
V
R
V
S
F
D
K
D
K
R
T
L
T
I
S
D
N
G
V
G
M
T
R
D
E
V
I
D
H
L
G
T
I
A
K
S
G
T
K
S
F
--
L
E
S
LGS
D
Q
A
K
D
S
Q
-
L
--
I
G
Q
F
G
V
G
F
Y
S
A
F
I
V
A
D
K
V
T
V
R
T
R
-
A
A
G
EK
P
E
--
N
G
V
F
W
E
S
A
G
E
G
E
Y
T
V
A
D
I
T
--
K
E
-
D
R
--
G
T
E
I
T
L
H
L
R
E
G
E
-----
D
E
F
L
D
D
W
R
V
R
S
I
I
S
K
Y
S
D
H
I
A
L
P
V
E
I
E
--------
K
R
E
E
K
D
--
T
V
I
S
W
E
K
I
N
K
A
Q
A
L
W
T
R
N
K
S
E
I
T
D
E
E
Y
K
E
F
Y
K
H
I
A
H
D
F
N
D
P
L
T
W
S
H
N
R
V
E
G
K
Q
E
Y
T
S
L
L
Y
I
P
S
Q
A
P
--
W
D
M
W
-
N
R
-
H
K
H
G
L
K
L
Y
V
Q
R
V
F
I
M
D
D
A
E
Q
F
M
P
N
Y
L
R
F
V
R
G
L
I
D
S
S
D
L
P
L
N
V
S
R
E
I
L
Q
D
S
T
V
T
R
N
L
R
N
A
L
T
K
R
V
L
Q
M
L
E
K
L
A
K
D
D
A
E
K
Y
-
Q
T
F
W
Q
Q
F
G
L
V
L
K
E
G
P
A
E
D
F
-
A
N
-
Q
E
A
I
A
K
L
L
R
F
A
S
T
HTD
S
---
S
-
A
Q
-
T
V
S
L
E
D
Y
V
S
R
M
K
E
G
Q
E
K
I
Y
Y
I
T
A
D
S
Y
A
A
A
K
S
S
P
H
L
E
L
L
R
K
K
G
I
E
V
L
L
L
S
D
R
I
D
E
W
M
M
N
Y
L
T
E
F
D
G
K
P
F
Q
S
V
S
K
V
D
E
S
L
E
KL-------------------------
F
I
D
R
V
K
A
-
L
L
G
E
R
V
K
D
V
R
L
T
H
R
L
T
D
T
P
A
I
V
S
T
D
A
D
E
-
M
--
S
T
Q
M
A
K
L
F
A
A
A
--------
G
-------
Q
-
K
--------
V
P
E
---
V
K
Y
I
F
E
L
N
P
D
H
V
L
V
K
R
A
A
----
D
T
--
E
--
D
---
E
--
A
--
K
F
S
E
W
V
E
L
L
L
D
Q
A
L
L
A
E
R
G
T
L
E
D
P
N
L
F
I
R
R
M
N
Q
L
L
V
-----
5
PsiBlast_PDB
75.11
36%
31
- C2 -
2O1U
3
?
A:
[34-655]
------------
M
M
K
L
I
I
N
S
L
Y
K
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
L
I
S
L
T
D
E
N
A
L
A
G
N
E
E
L
T
V
K
I
K
C
D
K
E
K
N
L
L
H
V
T
D
T
G
V
G
M
T
R
E
E
L
V
K
N
L
G
T
---------------------------------
V
G
F
Y
S
A
F
L
V
A
D
K
V
I
V
T
S
K
-
H
-
N
--
N
D
--
T
Q
H
I
W
E
S
D
S
N
E
F
S
V
I
A
D
P
R
--
G
N
-
T
L
G
R
G
T
T
I
T
L
V
L
K
E
E
A
S
D
-----
Y
L
E
L
D
T
I
K
N
L
V
K
K
Y
S
Q
F
I
N
F
P
I
Y
V
W
S
S
----
K
----------
V
W
D
W
E
L
M
N
D
I
K
P
I
W
Q
R
P
S
K
E
V
E
D
D
E
Y
K
A
F
Y
K
S
F
S
K
E
S
D
D
P
M
A
Y
I
H
F
T
A
E
G
E
V
T
F
K
S
I
L
F
V
P
T
S
A
P
R------------
Y
I
K
L
Y
V
R
R
V
F
I
T
D
D
F
H
D
M
M
P
K
Y
L
N
F
V
K
G
V
V
D
S
D
D
L
P
L
N
V
S
R
E
T
L
Q
Q
H
K
L
L
K
V
I
R
K
K
L
V
R
K
T
---
L
D
M
I
K
K
I
A
D
E
K
Y
N
D
T
F
W
K
E
F
G
T
N
I
K
L
G
V
I
E
D
H
-
S
N
-
R
T
R
L
A
K
L
L
R
F
Q
S
S
---
H
---
H
-
P
S
D
I
T
S
L
D
Q
Y
V
E
R
M
K
E
K
Q
D
K
I
Y
F
M
A
G
S
S
R
K
E
A
E
S
S
P
F
V
E
R
L
L
K
K
G
Y
E
V
I
Y
L
T
E
P
V
D
E
Y
C
I
Q
A
L
P
E
F
D
G
K
R
F
Q
N
V
A
K
E
G
V
K
F
D
-----
E
S
E
K
-
T
K
E
S
R
E
A
I
E
K
--
E
-
F
E
P
L
L
N
W
M
K
D
K
A
L
K
D
K
I
E
K
A
V
V
S
Q
R
L
T
E
S
P
C
A
L
V
A
S
Q
Y
G
-
W
--
S
G
N
M
E
R
I
M
K
A
Q
A
Y
Q
TGKD
I
S
-------
T
-
N
--------
Y
Y
A
SQ-
K
K
-
T
F
E
I
N
P
R
H
P
L
I
K
D
M
L
----
R
R
V
K
E
--
D
---
E
--
D
D
K
T
V
S
D
L
A
V
V
L
F
E
T
A
T
L
R
S
G
Y
L
L
P
D
T
K
A
Y
G
D
R
I
E
R
M
L
------
4
PsiBlast_PDB
73.69
37%
20
- C3 -
2CG9
1
HSP82_YEAST
A:
[7-672]
----
E
F
Q
A
E
I
T
Q
L
M
S
L
I
I
N
T
V
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
Y
K
S
L
S
D
P
K
Q
L
E
T
E
P
D
L
F
I
R
I
T
P
K
P
E
Q
K
V
L
E
I
R
D
S
G
I
G
M
T
K
A
E
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
--
M
E
A
-----
L
S
A
G
A
D
V
S
M
I
G
Q
F
G
V
G
F
Y
S
L
F
L
V
A
D
R
V
Q
V
I
S
K
-
S
-
N
--
D
D
--
E
Q
Y
I
W
E
S
N
A
G
G
S
F
T
V
T
L
D
E
V-
N
E
-
R
I
--
G
R
G
T
I
L
R
L
--
F
L
K
D
D
Q
L
-
E
Y
L
E
E
K
R
I
K
E
V
I
K
R
H
S
E
F
V
A
Y
P
I
Q
L
V
V
T
K
E
V
E
K
-
E
------
E
E
V
Q
E
I
E
E
L
N
K
T
K
P
L
W
T
R
N
P
S
D
I
T
Q
E
E
Y
N
A
F
Y
K
S
I
S
N
D
W
E
D
P
L
Y
V
K
H
F
S
V
E
G
Q
L
E
F
R
A
I
L
F
I
P
K
R
A
P
--
F
---------
N
N
I
K
L
Y
V
R
R
V
F
I
T
D
E
A
E
D
L
I
P
E
W
L
S
F
V
K
G
V
V
D
S
E
D
L
P
L
N
L
S
R
E
M
L
Q
Q
N
K
I
M
K
V
I
R
K
N
I
V
K
K
L
I
E
A
F
N
E
I
-
A
E
D
S
E
Q
F
-
E
K
F
Y
S
A
F
S
K
N
I
K
L
G
V
H
E
D
-
T
Q
N
-
R
A
A
L
A
K
L
L
R
Y
N
S
T
---
K
---
S
V
D
E
-
L
T
S
L
T
D
Y
V
T
R
M
P
E
H
Q
K
N
I
Y
Y
I
T
G
E
S
L
K
A
V
E
K
S
P
F
L
D
A
L
K
A
K
N
F
E
V
L
F
L
T
D
P
I
D
E
Y
A
F
T
Q
L
K
E
F
E
G
K
T
L
V
D
I
T
K
D
F
E
L
E
E
-----
T
D
E
E
-
K
A
E
R
E
K
E
-
I
K
--
E
-
Y
E
P
L
T
K
A
L
K
E
-
I
L
G
D
Q
V
E
K
V
V
V
S
Y
K
L
L
D
A
P
A
A
I
R
T
-
G
-
Q
-
F
GW
S
A
N
M
E
R
I
M
K
A
Q
A
---------------------------------
K
-
T
F
E
I
S
P
K
S
P
I
I
K
E
L
K
K
R
VD
E
G
G
A
Q
--
D
---
K
--
T
--
V
K
D
L
-
T
K
L
L
Y
E
T
A
L
L
T
S
G
F
S
L
D
E
P
T
S
F
A
S
R
I
N
R
L
I
------
25
PsiBlast_CBE
73.26
36%
30
- C2 -
2O1U
3
?
B:
[36-655]
--------------
K
L
I
I
N
S
L
Y
K
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
L
I
S
L
T
D
E
N
A
L
A
G
N
E
E
L
T
V
K
I
K
C
D
K
E
K
N
L
L
H
V
T
D
T
G
V
G
M
T
R
E
E
L
V
K
N
L
G
T
---------------------------------
V
G
F
Y
S
A
F
L
V
A
D
K
V
I
V
T
S
K
-
H
-
N
--
N
D
--
T
Q
H
I
W
E
S
D
S
N
E
F
S
V
I
A
D
P
R
--
G
N
-
T
L
G
R
G
T
T
I
T
L
V
L
K
E
E
A
S
D
-----
Y
L
E
L
D
T
I
K
N
L
V
K
K
Y
S
Q
F
I
N
F
P
I
Y
V
W
S
S
----
K
-
T
--------
V
W
D
W
E
L
M
N
D
I
K
P
I
W
Q
R
P
S
K
E
V
E
D
D
E
Y
K
A
F
Y
K
S
F
S
K
E
S
D
D
P
M
A
Y
I
H
F
T
A
E
G
E
V
T
F
K
S
I
L
F
V
P
T
S
A
--------------
Y
I
K
L
Y
V
R
R
V
F
I
T
D
D
F
H
D
M
M
P
K
Y
L
N
F
V
K
G
V
V
D
S
D
D
L
P
L
N
V
S
R
E
T
L
Q
Q
H
K
L
L
K
V
I
R
K
K
L
V
R
K
T
---
L
D
M
I
K
K
I
A
D
E
K
Y
N
D
T
F
W
K
E
F
G
T
N
I
K
L
G
V
I
E
D
H
-
S
N
-
R
T
R
L
A
K
L
L
R
F
Q
S
S
---
H
---
H
-
P
S
D
I
T
S
L
D
Q
Y
V
E
R
M
K
E
K
Q
D
K
I
Y
F
M
A
G
S
S
R
K
E
A
E
S
S
P
F
V
E
R
L
L
K
K
G
Y
E
V
I
Y
L
T
E
P
V
D
E
Y
C
I
Q
A
L
P
E
F
D
G
K
R
F
Q
N
V
A
K
E
G
V
K
F
D
-----
E
S
E
K
-
T
K
E
S
R
E
A
I
E
K
--
E
-
F
E
P
L
L
N
W
M
K
D
K
A
L
K
D
K
I
E
K
A
V
V
S
Q
R
L
T
E
S
P
C
A
L
V
A
S
Q
Y
G
-
W
--
S
G
N
M
E
R
I
M
K
A
Q
A
Y
Q
TGKD
I
S
-------
T
-
N
--------
Y
Y
A
S
Q
-
K
K
-
T
F
E
I
N
P
R
H
P
L
I
K
D
M
L
----
R
R
V
K
E
--
D
---
E
--
D
D
K
T
V
S
D
L
A
V
V
L
F
E
T
A
T
L
R
S
G
Y
L
L
P
D
T
K
A
Y
G
D
R
I
E
R
M
L
------
23
PsiBlast_CBE
72.18
37%
34
- C3 -
2CG9
1
HSP82_YEAST
B:
[7-672]
----
E
F
Q
A
E
I
T
Q
L
M
S
L
I
I
N
T
V
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
Y
K
S
L
S
D
P
K
Q
L
E
T
E
P
D
L
F
I
R
I
T
P
K
P
E
Q
K
V
L
E
I
R
D
S
G
I
G
M
T
K
A
E
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
--
M
E
A
-----
L
S
A
G
A
D
V
S
M
I
G
Q
F
G
V
G
F
Y
S
L
F
L
V
A
D
R
V
Q
V
I
S
K
-
S
-
N
--
D
D
--
E
Q
Y
I
W
E
S
N
A
G
G
S
F
T
V
T
L
D
E
V-
N
E
-
R
I
--
G
R
G
T
I
L
R
L
--
F
L
K
D
D
Q
L
-
E
Y
L
E
E
K
R
I
K
E
V
I
K
R
H
S
E
F
V
A
Y
P
I
Q
L
V
V
T
K
E
V
E
K
-
E
------
E
E
V
Q
E
I
E
E
L
N
K
T
K
P
L
W
T
R
N
P
S
D
I
T
Q
E
E
Y
N
A
F
Y
K
S
I
S
N
D
W
E
D
P
L
Y
V
K
H
F
S
V
E
G
Q
L
E
F
R
A
I
L
F
I
P
K
R
A
P
--
F
D
L
F
E
S
K
K
K
K
N
N
I
K
L
Y
V
R
R
V
F
I
T
D
E
A
E
D
L
I
P
E
W
L
S
F
V
K
G
V
V
D
S
E
D
L
P
L
N
L
S
R
E
M
L
Q
Q
N
K
I
M
K
V
I
R
K
N
I
V
K
K
L
I
E
A
F
N
E
I
-
A
E
D
S
E
Q
F
-
E
K
F
Y
S
A
F
S
K
N
I
K
L
G
V
H
E
D
-
T
Q
N
-
R
A
A
L
A
K
L
L
R
Y
N
S
T
---
K
---
S
V
D
E
-
L
T
S
L
T
D
Y
V
T
R
M
P
E
H
Q
K
N
I
Y
Y
I
T
G
E
S
L
K
A
V
E
K
S
P
F
L
D
A
L
K
A
K
N
F
E
V
L
F
L
T
D
P
I
D
E
Y
A
F
T
Q
L
K
E
F
E
G
K
T
L
V
D
I
T
K
D
F
E
L
E
E
-----
T
D
E
E
-
K
A
E
R
E
K
E
-
I
K
--
E
-
Y
E
P
L
T
K
A
L
K
E
-
I
L
G
D
Q
V
E
K
V
V
V
S
Y
K
L
L
D
A
P
A
A
I
R
T
-
G
-
Q
-
F
GW
S
A
N
M
E
R
I
M
K
A
Q
A
---------------------------------
K
-
T
F
E
I
S
P
K
S
P
I
I
K
E
L
K
K
R
VD
E
G
G
A
Q
--
D
---
K
--
T
--
V
K
D
L
-
T
K
L
L
Y
E
T
A
L
L
T
S
G
F
S
L
D
E
P
T
S
F
A
S
R
I
N
R
L
I
------
26
PsiBlast_CBE
71.87
31%
29
- C3 -
4J0B
4
?
B:
[29-641]
-
S
K
H
E
F
Q
A
E
T
K
K
L
L
D
I
V
A
R
S
L
Y
S
E
K
E
V
F
I
R
E
L
I
S
N
G
S
D
A
L
E
K
L
R
H
R
M
I
T
A
G
------
A
P
M
E
I
H
L
Q
T
D
S
V
K
G
T
F
T
I
Q
D
T
G
V
G
M
N
K
E
D
L
V
S
N
L
G
T
I
A
R
S
G
S
K
A
F
L
D
A
L
Q
--------
S
S
S
I
--
I
G
Q
F
G
V
G
F
Y
S
A
F
M
V
A
D
K
V
E
V
Y
S
Q
S
A
E
A
--
D
A
--
P
G
Y
K
W
S
S
D
G
S
G
V
F
E
V
A
E
A
S
--
G
V
-
R
Q
--
G
T
K
I
V
L
H
L
K
-----
D
D
C
K
E
F
S
S
E
D
R
V
K
E
V
V
T
K
Y
S
N
F
V
S
F
P
I
F
L
N
G
--------------------
R
R
L
N
T
L
Q
A
L
W
M
M
E
P
K
D
I
S
E
W
Q
H
E
E
F
Y
R
Y
V
A
Q
A
Y
D
K
P
R
Y
T
L
H
Y
R
A
D
A
P
L
N
I
R
S
I
F
Y
V
P
E
M
K
P
S
M
F
D
V
--
S
R
E
M
--
S
V
A
L
Y
S
R
K
I
L
I
Q
T
K
--
D
I
L
P
K
W
L
R
F
L
R
G
V
V
D
S
E
D
I
P
L
N
L
S
R
E
L
L
Q
E
S
A
L
I
R
K
L
R
D
V
L
Q
Q
R
V
I
R
F
L
L
D
Q
S
K
K
D
P
E
K
Y
-
A
R
F
F
E
D
Y
G
L
F
M
R
E
G
I
V
T
T
G
E
Q
S
V
K
E
D
I
A
K
L
L
R
F
E
S
S
AL-
P
---
A
-
G
Q
-
Q
T
S
L
M
E
Y
S
S
R
M
K
A
G
T
R
N
I
Y
Y
L
C
A
P
N
R
H
L
A
E
H
S
P
Y
F
E
A
M
K
Q
K
D
M
E
V
L
F
C
F
E
Q
F
D
E
L
T
L
L
H
L
R
E
F
D
R
K
K
L
I
S
A
E
T
-
D
I
V
V
D
H
Y
K
E
E
K
F
Q
D
-
S
K
P
A
S
E
R
-
L
S
S
E
Q
-
A
E
D
L
L
A
W
M
R
N
-
A
L
V
Q
R
V
T
N
I
K
V
T
P
R
L
D
T
H
P
A
M
I
-------
T
--
V
L
E
M
G
A
A
R
H
F
L
R
------
T
----------------------IL-
Q
P
-
T
L
E
I
N
T
G
H
D
L
I
K
K
L
H
----
A
L
K
D
S
--
N
---
P
--
E
--
L
A
Q
L
L
L
E
Q
I
Y
D
N
A
M
I
A
A
G
L
N
-
E
D
P
R
P
M
I
S
R
L
N
Q
L
L
T
-----
22
PsiBlast_CBE
68.91
40%
23
- C2 -
1Y4S
2
HTPG_ECOLI
B:
[7-483]
---
R
G
F
Q
S
E
V
K
Q
L
L
H
L
M
I
H
S
L
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
A
D
K
L
R
F
R
A
L
S
N
P
D
L
Y
E
G
D
G
E
L
R
V
R
V
S
F
D
K
D
K
R
T
L
T
I
S
D
N
G
V
G
M
T
R
D
E
V
I
D
H
L
G
T
I
A
K
S
G
T
K
S
F
--
L
E
S
--------
S
Q
-
L
--
I
G
Q
F
G
V
G
F
Y
S
A
F
I
V
A
D
K
V
T
V
R
T
R
-
A
A
G
EK
P
E
--
N
G
V
F
W
E
S
A
G
E
G
E
Y
T
V
A
D
I
T
--
K
E
-
D
R
--
G
T
E
I
T
L
H
L
R
E
G
E
-----
D
E
F
L
D
D
W
R
V
R
S
I
I
S
K
Y
S
D
H
I
A
L
P
V
E
I
E
--------
K
R
E
E
K
D
G
E
T
V
I
S
W
E
K
I
N
K
A
Q
A
L
W
T
R
N
K
S
E
I
T
D
E
E
Y
K
E
F
Y
K
H
I
A
H
D
F
N
D
P
L
T
W
S
H
N
R
V
E
G
K
Q
E
Y
T
S
L
L
Y
I
P
S
Q
A
P
--
W
D
M
W
-
N
R
D
H
K
H
G
L
K
L
Y
V
Q
R
V
F
I
M
D
D
A
E
Q
F
M
P
N
Y
L
R
F
V
R
G
L
I
D
S
S
D
L
P
L
N
V
S
R
E
I
L
Q
D
S
T
V
T
R
N
L
R
N
A
L
T
K
R
V
L
Q
M
L
E
K
L
A
K
D
D
A
E
K
Y
-
Q
T
F
W
Q
Q
F
G
L
V
L
K
E
G
P
A
E
D
F
-
A
N
-
Q
E
A
I
A
K
L
L
R
F
A
S
T
HTD
S
---
S
-
A
Q
-
T
V
S
L
E
D
Y
V
S
R
M
K
E
G
Q
E
K
I
Y
Y
I
T
A
D
S
Y
A
A
A
K
S
S
P
H
L
E
L
L
R
K
K
G
I
E
V
L
L
L
S
D
R
I
D
E
W
M
M
N
Y
L
T
E
F
D
G
K
P
F
Q
S
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
119
HHSearch
66.58
41%
29
- C2 -
1Y4S
2
HTPG_ECOLI
A:
[4-483]
Q
E
T
R
G
F
Q
S
E
V
K
Q
L
L
H
L
M
I
H
S
L
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
A
D
K
L
R
F
R
A
L
S
N
P
D
L
Y
E
G
D
G
E
L
R
V
R
V
S
F
D
K
D
K
R
T
L
T
I
S
D
N
G
V
G
M
T
R
D
E
V
I
D
H
L
G
T
I
A
K
S
G
T
K
S
F
--
L
E
S
---------
S
Q
L
--
I
G
Q
F
G
V
G
F
Y
S
A
F
I
V
A
D
K
V
T
V
R
T
R
-
A
A
G
--
E
K
PE
N
G
V
F
W
E
S
A
G
E
G
E
Y
T
V
A
D
I
T
--
K
E
-
D
R
--
G
T
E
I
T
L
H
L
R
E
----
G
E
D
-
E
F
L
D
D
W
R
V
R
S
I
I
S
K
Y
S
D
H
I
A
L
P
V
E
I
E
K
R
E
E
K
--------
D
G
E
T
V
I
S
W
E
K
I
N
K
A
Q
A
L
W
T
R
N
K
S
E
I
T
D
E
E
Y
K
E
F
Y
K
H
I
A
H
D
F
N
D
P
L
T
W
S
H
N
R
V
E
G
K
Q
E
Y
T
S
L
L
Y
I
P
S
Q
A
P
--
W
D
M
W
-
N
R
D
H
K
H
G
L
K
L
Y
V
Q
R
V
F
I
M
D
D
A
E
Q
F
M
P
N
Y
L
R
F
V
R
G
L
I
D
S
S
D
L
P
L
N
V
S
R
E
I
L
Q
D
S
T
V
T
R
N
L
R
N
A
L
T
K
R
V
L
Q
M
L
E
K
L
A
K
D
D
A
E
K
Y
-
Q
T
F
W
Q
Q
F
G
L
V
L
K
E
G
P
A
E
D
F
-
A
N
-
Q
E
A
I
A
K
L
L
R
F
A
S
T
---
H
TDS
S
-
A
Q
-
T
V
S
L
E
D
Y
V
S
R
M
K
E
G
Q
E
K
I
Y
Y
I
T
A
D
S
Y
A
A
A
K
S
S
P
H
L
E
L
L
R
K
K
G
I
E
V
L
L
L
S
D
R
I
D
E
W
M
M
N
Y
L
T
E
F
D
G
K
P
F
Q
S
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
66.24
40%
28
- C2 -
1Y4S
2
HTPG_ECOLI
A:
[7-483]
---
R
G
F
Q
S
E
V
K
Q
L
L
H
L
M
I
H
S
L
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
A
D
K
L
R
F
R
A
L
S
N
P
D
L
Y
E
G
D
G
E
L
R
V
R
V
S
F
D
K
D
K
R
T
L
T
I
S
D
N
G
V
G
M
T
R
D
E
V
I
D
H
L
G
T
I
A
K
S
G
T
K
S
F
--
L
E
S
--------
S
Q
-
L
--
I
G
Q
F
G
V
G
F
Y
S
A
F
I
V
A
D
K
V
T
V
R
T
R
-
A
A
G
EK
P
E
--
N
G
V
F
W
E
S
A
G
E
G
E
Y
T
V
A
D
I
T
--
K
E
-
D
R
--
G
T
E
I
T
L
H
L
R
E
G
E
-----
D
E
F
L
D
D
W
R
V
R
S
I
I
S
K
Y
S
D
H
I
A
L
P
V
E
I
E
--------
K
R
E
E
K
D
G
E
T
V
I
S
W
E
K
I
N
K
A
Q
A
L
W
T
R
N
K
S
E
I
T
D
E
E
Y
K
E
F
Y
K
H
I
A
H
D
F
N
D
P
L
T
W
S
H
N
R
V
E
G
K
Q
E
Y
T
S
L
L
Y
I
P
S
Q
A
P
--
W
D
M
W
-
N
R
D
H
K
H
G
L
K
L
Y
V
Q
R
V
F
I
M
D
D
A
E
Q
F
M
P
N
Y
L
R
F
V
R
G
L
I
D
S
S
D
L
P
L
N
V
S
R
E
I
L
Q
D
S
T
V
T
R
N
L
R
N
A
L
T
K
R
V
L
Q
M
L
E
K
L
A
K
D
D
A
E
K
Y
-
Q
T
F
W
Q
Q
F
G
L
V
L
K
E
G
P
A
E
D
F
-
A
N
-
Q
E
A
I
A
K
L
L
R
F
A
S
T
HTD
S
---
S
-
A
Q
-
T
V
S
L
E
D
Y
V
S
R
M
K
E
G
Q
E
K
I
Y
Y
I
T
A
D
S
Y
A
A
A
K
S
S
P
H
L
E
L
L
R
K
K
G
I
E
V
L
L
L
S
D
R
I
D
E
W
M
M
N
Y
L
T
E
F
D
G
K
P
F
Q
S
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
65.36
34%
8
- C3 -
4Z1I
2
TRAP1_HUMAN
C:
[27-494]
-
S
K
H
E
F
Q
A
E
T
K
K
L
L
D
I
V
A
R
S
L
Y
S
E
K
E
V
F
I
R
E
L
I
S
N
A
S
D
A
L
E
K
L
R
H
K
-
L
V
S
D
G
Q
A
L
P
E
M
E
I
H
L
Q
T
N
A
E
K
G
--
T
I
T
I
Q
D
T
G
I
G
M
T
Q
E
E
L
V
S
N
L
G
T
I
A
R
S
G
S
K
A
F
L
D
A
L
------
A
E
A
S
S
K
I
--
I
G
Q
F
G
V
G
F
Y
S
A
F
M
V
A
D
R
V
E
V
Y
S
R
S
A
A
P
--
G
S
--
L
G
Y
Q
W
L
S
D
G
S
G
V
F
E
I
A
E
A
S
--
G
V
-
R
T
--
G
T
K
I
I
I
H
L
K
S
D
C
K
-----
E
F
S
S
E
A
R
V
R
D
V
V
T
K
Y
S
N
F
V
S
F
P
L
Y
L
N
G
--------------------
R
R
M
N
T
L
Q
A
I
W
M
M
D
P
K
D
V
R
E
W
Q
H
E
E
F
Y
R
Y
V
A
Q
A
H
D
K
P
R
Y
T
L
H
Y
K
T
D
A
P
L
N
I
R
S
I
F
Y
V
P
D
M
K
P
------------
S
S
V
A
L
Y
S
R
K
V
L
I
Q
T
K
A
T
D
I
L
P
K
W
L
R
F
I
R
G
V
V
D
S
E
D
I
P
L
N
L
S
R
E
L
L
Q
E
S
A
L
I
R
K
L
R
D
V
L
Q
Q
R
L
I
K
F
F
I
D
Q
S
K
K
D
A
E
K
Y
-
A
K
F
F
E
D
Y
G
L
F
M
R
E
G
I
V
T
A
T
E
Q
E
V
K
E
D
I
A
K
L
L
R
Y
E
S
S
---
A
LP-
S
-
G
Q
-
L
T
S
L
S
E
Y
A
S
R
M
R
A
G
T
R
N
I
Y
Y
L
C
A
P
N
R
H
L
A
E
H
S
P
Y
Y
E
A
M
K
K
K
D
T
E
V
L
F
C
F
E
Q
F
D
E
L
T
L
L
H
L
R
E
F
D
K
K
K
L
I
S
V
E
T
-
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
65.34
34%
9
- C3 -
4Z1I
2
TRAP1_HUMAN
B:
[27-494]
-
S
K
H
E
F
Q
A
E
T
K
K
L
L
D
I
V
A
R
S
L
Y
S
E
K
E
V
F
I
R
E
L
I
S
N
A
S
D
A
L
E
K
L
R
H
K
-
L
V
S
D
G
Q
A
L
P
E
M
E
I
H
L
Q
T
N
A
E
K
G
--
T
I
T
I
Q
D
T
G
I
G
M
T
Q
E
E
L
V
S
N
L
G
T
I
A
R
S
G
S
K
A
F
L
D
A
-------
A
E
A
S
S
K
I
--
I
G
Q
F
G
V
G
F
Y
S
A
F
M
V
A
D
R
V
E
V
Y
S
R
S
A
A
P
--
G
S
--
L
G
Y
Q
W
L
S
D
G
S
G
V
F
E
I
A
E
A
S
--
G
V
-
R
T
--
G
T
K
I
I
I
H
L
K
S
D
C
K
-----
E
F
S
S
E
A
R
V
R
D
V
V
T
K
Y
S
N
F
V
S
F
P
L
Y
L
N
G
--------------------
R
R
M
N
T
L
Q
A
I
W
M
M
D
P
K
D
V
R
E
W
Q
H
E
E
F
Y
R
Y
V
A
Q
A
H
D
K
P
R
Y
T
L
H
Y
K
T
D
A
P
L
N
I
R
S
I
F
Y
V
P
D
M
K
P
SM
F
----------
S
V
A
L
Y
S
R
K
V
L
I
Q
T
K
A
T
D
I
L
P
K
W
L
R
F
I
R
G
V
V
D
S
E
D
I
P
L
N
L
S
R
E
L
L
Q
E
S
A
L
I
R
K
L
R
D
V
L
Q
Q
R
L
I
K
F
F
I
D
Q
S
K
K
D
A
E
K
Y
-
A
K
F
F
E
D
Y
G
L
F
M
R
E
G
I
V
T
A
T
E
Q
E
V
K
E
D
I
A
K
L
L
R
Y
E
S
S
---
A
LP-
S
-
G
Q
-
L
T
S
L
S
E
Y
A
S
R
M
R
A
G
T
R
N
I
Y
Y
L
C
A
P
N
R
H
L
A
E
H
S
P
Y
Y
E
A
M
K
K
K
D
T
E
V
L
F
C
F
E
Q
F
D
E
L
T
L
L
H
L
R
E
F
D
K
K
K
L
I
S
V
E
T
-
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
65.20
40%
38
- C2 -
1Y4U
-
HTPG_ECOLI
A:
[7-489]
---
R
G
F
Q
S
E
V
K
Q
L
L
H
L
M
I
H
S
L
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
A
D
K
L
R
F
R
A
L
S
N
P
D
L
Y
E
G
D
G
E
L
R
V
R
V
S
F
D
K
D
K
R
T
L
T
I
S
D
N
G
V
G
M
T
R
D
E
V
I
D
H
L
G
T
I
A
K
S
G
T
----------------------
I
G
Q
F
G
V
G
F
Y
S
A
F
I
V
A
D
K
V
T
V
R
T
R
-
A
A
G
EK
P
E
--
N
G
V
F
W
E
S
A
G
E
G
E
Y
T
V
A
D
I
T
--
K
E
-
D
R
--
G
T
E
I
T
L
H
L
R
E
G
E
-----
D
E
F
L
D
D
W
R
V
R
S
I
I
S
K
Y
S
D
H
I
A
L
P
V
E
I
E
--------
K
R
E
E
K
D
G
E
T
V
I
S
W
E
K
I
N
K
A
Q
A
L
W
T
R
N
K
S
E
I
T
D
E
E
Y
K
E
F
Y
K
H
I
A
H
D
F
N
D
P
L
T
W
S
H
N
R
V
E
G
K
Q
E
Y
T
S
L
L
Y
I
P
S
Q
A
P
--
W
D
M
W
-
N
R
D
H
K
H
G
L
K
L
Y
V
Q
R
V
F
I
M
D
D
A
E
Q
F
M
P
N
Y
L
R
F
V
R
G
L
I
D
S
S
D
L
P
L
N
V
S
R
E
I
L
Q
D
S
T
V
T
R
N
L
R
N
A
L
T
K
R
V
L
Q
M
L
E
K
L
A
K
D
D
A
E
K
Y
-
Q
T
F
W
Q
Q
F
G
L
V
L
K
E
G
P
A
E
D
F
-
A
N
-
Q
E
A
I
A
K
L
L
R
F
A
S
T
HTD
S
---
S
-
A
Q
-
T
V
S
L
E
D
Y
V
S
R
M
K
E
G
Q
E
K
I
Y
Y
I
T
A
D
S
Y
A
A
A
K
S
S
P
H
L
E
L
L
R
K
K
G
I
E
V
L
L
L
S
D
R
I
D
E
W
M
M
N
Y
L
T
E
F
D
G
K
P
F
Q
S
V
S
K
V
D
E
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------