@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu40400: (2016-08-07 )
MNKVGFFRSIQFKITLIYVLLIIIAMQIIGVYFVNQVEKSLISSYEQSLNQRIDNLSYYIEQEYKSDNDSTVIKDDVSRILNDFTKSDEVREISFVDKSYEVVGSSKPYGEEVAGKQTTDLIFKRIFSTKQSYLRKYYDPKSKIRVLISAKPVMTENQEVVGAIYVVASMEDVFNQMKTINTILASGTGLALVLTALLGIFLARTITHPLSDMRKQAMELAKGNFSRKVKKYGHDEIGQLATTFNHLTRELEDAQAMTEGERRKLASVIAYMTDGVIATNRNGAIILLNSPALELLNVSRETALEMPITSLLGLQENYTFEDLVEQQDSMLLEIERDDELTVLRVNFSVIQREHGKIDGLIAVIYDVTEQEKMDQERREFVANVSHELRTPLTTMRSYLEALAEGAWENKDIAPRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQFNREWIQIVRFMSLIIDRFEMTKEQHVEFIRNLPDRDLYVEIDQDKITQVLDNIISNALKYSPEGGHVTFSIDVNEEEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKLGGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTITFTLPYKEEQEDDWDEA
Atome Classification :
(23 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......-320.......330..-..--.--..340.......350....-...360.......370....---------...380.......390.......400......-.410.......420.......430.......440.......450.......460.---....------..-470----.--.....-..480.......490.......500.......510....-...520.......530.......540.......550.......560.......570....-...580.......590.......-600.......610
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNKVG
F
F
R
S
I
Q
F
K
I
T
L
I
Y
V
L
L
I
I
I
A
M
Q
I
I
G
V
Y
F
V
N
Q
V
E
K
S
L
I
S
S
Y
E
Q
S
L
N
Q
R
I
D
N
L
S
Y
Y
I
E
Q
E
YKSDNDST
V
I
K
D
D
V
S
R
I
L
N
D
FTKSDEV
R
E
I
S
FVDK
S
Y
E
VVGSSKPY
G
E
E
VAGK
Q
T
T
D
L
I
F
K
R
I
F
S
T
K
Q
S
Y
L
R
K
YYDP
K
S
K
I
R
V
L
I
SAKPVMTENQ
E
V
V
G
A
I
Y
V
VA
S
M
E
D
V
F
N
Q
M
K
T
I
N
T
I
L
ASG
T
G
L
A
L
V
L
T
A
L
L
G
I
F
L
A
R
T
ITH
P
L
S
D
M
R
K
Q
A
M
E
L
AKG
N
F
S
R
K
V
K
K
YG
H
D
E
I
G
Q
L
A
T
T
F
N
H
L
T
R
E
L
E
D
A
Q
A
M
T
E
G
E
R
R
K
L
A
S
V
I
A
Y
MTD
G
V
I
ATNRN
G
A
I
I
L
LNSP
A
L
E
L
L
NVS
R
E
T
A
LEM
P
I
T
S
L
LGLQENY
T
-
F
E
D
L
V
E
Q
QD
S
M
L
L
E
I
-ER--D--D
E
L
T
V
L
R
V
N
F
S
V
I
Q
R
EHGK-I
D
G
L
I
A
V
I
YDV
T
E
Q
E
K
M
D
Q
E
---------
R
R
E
F
V
A
N
V
S
H
E
LRT
P
L
T
T
M
R
S
Y
L
E
A
L
A
EGAWE-NKDIA
P
R
F
L
M
V
TQN
E
T
E
R
M
I
R
L
V
N
D
L
L
Q
L
S
KFDSKDYQF
N
R
E
W
I
Q
I
V
R
F
M
S
L
I
I
D
---
R
F
EM------
T
K
-
E
Q
-----
H
--
V
E
F
I
R-NLPDR
D
L
Y
V
E
I
D
Q
D
K
I
T
Q
V
L
D
N
I
I
S
N
A
LKYSPEG
G
H
V
T
F
-
S
I
DVNEEE
E
L
L
Y
I
S
V
KDEGIGI
P
K
K
D
V
E
K
V
F
D
R
F
Y
R
V
D
K
A
R
T
RKLGGTG
L
G
L
A
I
A
K
E
M
V
Q
-AHGGDIWADSIEGKG
T
T
I
T
F
TLP-YKEEQEDDWDEA
87
Fugue
72.94
46%
-15
- C4 -
4I5S
-
?
A:
[37-432]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
N
N
Q
V
K
Q
L
N
A
K
V
R
S
L
I
T
G
H
Y
T
D
K
L
K
V
E
D
N
S
D
L
S
E
L
V
N
N
V
N
D
L
S
E
V
F
R
L
T
H
E
N
L
A
Q
E
K
N
R
L
T
S
I
L
S
Y
M
T
D
G
V
L
A
T
D
R
S
G
K
I
T
V
I
N
D
M
A
Q
K
Q
L
N
V
T
R
E
Q
A
L
E
C
N
I
L
D
I
L
D
-
D
D
S
Y
T
-
Y
N
D
L
I
T
K
T
P
E
I
V
L
T
R
R
D
E
--
Y
--
D
E
F
I
T
L
R
I
R
F
A
L
N
R
R
E
S
G
F
-
I
S
G
L
I
A
V
L
H
D
A
T
E
Q
E
K
E
E
R
E
---------
R
R
L
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
V
K
S
Y
L
E
A
L
D
D
G
A
L
T
-
E
S
-
V
A
P
S
F
I
K
V
S
L
D
E
T
N
R
M
M
R
M
I
T
D
L
L
S
L
S
R
-----
S
H
L
D
V
E
L
T
N
F
T
A
F
M
N
Y
I
L
D
---
R
F
D
Q
------
I
Q
S
Q
Q
-----
S
--
T
E
I
I
R
-
D
Y
P
D
K
S
V
W
I
E
I
D
T
D
K
M
T
Q
V
I
D
N
I
L
N
N
A
I
K
Y
S
P
D
G
G
K
V
T
I
-
T
M
Q
T
T
D
T
Q
--
L
I
L
S
I
S
D
Q
G
L
G
I
P
K
K
D
L
P
L
I
F
D
R
F
Y
R
V
D
K
A
R
-------
G
L
G
L
A
I
A
K
E
I
V
K
-
Q
H
K
G
F
I
W
A
N
S
E
E
G
E
G
S
T
F
T
I
V
L
P
-------------
1
PsiBlast_PDB
70.86
45%
4
- C4 -
4I5S
-
?
A:
[44-432]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
A
K
V
R
S
L
I
T
G
H
Y
T
D
K
L
K
V
E
D
N
S
D
L
S
E
L
V
N
N
V
N
D
L
S
E
V
F
R
L
T
H
E
N
L
A
Q
E
K
N
R
L
T
S
I
L
S
Y
M
T
D
G
V
L
A
T
D
R
S
G
K
I
T
V
I
N
D
M
A
Q
K
Q
L
N
V
T
R
E
Q
A
L
E
C
N
I
L
D
I
L
D
-
D
D
S
Y
T
-
Y
N
D
L
I
T
K
T
P
E
I
V
L
-
T
-
R
R
--
D
EY
D
E
F
I
T
L
R
I
R
F
A
L
N
R
R
E
S
G
F
-
I
S
G
L
I
A
V
L
H
D
A
T
E
Q
E
K
E
E
R
E
---------
R
R
L
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
V
K
S
Y
L
E
A
L
D
D
G
A
L
--
T
E
S
V
A
P
S
F
I
K
V
S
L
D
E
T
N
R
M
M
R
M
I
T
D
L
L
S
L
S
R
-----
S
H
L
D
V
E
L
T
N
F
T
A
F
M
N
Y
I
L
D
---
R
F
D
Q
------
I
Q
-
S
Q
-----
Q
ST-
E
I
I
R
-
D
Y
P
D
K
S
V
W
I
E
I
D
T
D
K
M
T
Q
V
I
D
N
I
L
N
N
A
I
K
Y
S
P
D
G
G
K
V
T
I
-
T
M
Q
T
T
D
T
Q
--
L
I
L
S
I
S
D
Q
G
L
G
I
P
K
K
D
L
P
L
I
F
D
R
F
Y
R
V
D
K
A
R
-------
G
L
G
L
A
I
A
K
E
I
V
K
-
Q
H
K
G
F
I
W
A
N
S
E
E
G
E
G
S
T
F
T
I
V
L
P
-------------
97
HHSearch
69.91
43%
3
- C4 -
4I5S
-
?
A:
[37-432]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
N
N
Q
V
K
Q
L
N
A
K
V
R
S
L
I
T
G
H
Y
T
D
K
L
K
V
E
D
N
S
D
L
S
E
L
V
N
N
V
N
D
L
S
E
V
F
R
L
T
H
E
N
L
A
Q
E
K
N
R
L
T
S
I
L
S
Y
M
T
D
G
V
L
A
T
D
R
S
G
K
I
T
V
I
N
D
M
A
Q
K
Q
L
N
V
T
R
E
Q
A
L
E
C
N
I
L
D
I
L
D
D
D
S
Y
-
T
-
Y
N
D
L
I
T
K
-
T
P
E
I
V
L
T
-
R
R
DE
Y
--
D
E
F
I
T
L
R
I
R
F
A
L
N
R
R
E
S
G
F
-
I
S
G
L
I
A
V
L
H
D
A
T
E
Q
E
K
E
E
R
E
---------
R
R
L
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
V
K
S
Y
L
E
A
L
D
D
G
A
L
T
--
E
S
V
A
P
S
F
I
K
V
S
L
D
E
T
N
R
M
M
R
M
I
T
D
L
L
S
L
S
R
-----
S
H
L
D
V
E
L
T
N
F
T
A
F
M
N
Y
I
L
D
---
R
F
D
Q
------
I
Q
S
Q
Q
ST-------
E
I
I
R
-
D
Y
P
D
K
S
V
W
I
E
I
D
T
D
K
M
T
Q
V
I
D
N
I
L
N
N
A
I
K
Y
S
P
D
G
G
K
V
T
I
-
T
M
Q
T
T
--
D
T
Q
L
I
L
S
I
S
D
Q
G
L
G
I
P
K
K
D
L
P
L
I
F
D
R
F
Y
R
V
D
K
A
R
-------
G
L
G
L
A
I
A
K
E
I
V
K
-
Q
H
K
G
F
I
W
A
N
S
E
E
G
E
G
S
T
F
T
I
V
L
P
-------------
2
PsiBlast_PDB
67.52
100%
-141
- C3 -
3SL2
2
A:
[2-153]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
I
Q
I
V
R
F
M
S
L
I
I
D
---
R
F
E
M
------
T
K
-
E
Q
---------
E
F
I
R
-
N
L
P
D
R
D
L
Y
V
E
I
D
Q
D
K
I
T
Q
V
L
D
N
I
I
S
N
A
L
K
Y
S
P
E
G
G
H
V
T
F
-
S
I
D
V
N
E
E
E
E
L
L
Y
I
S
V
K
D
E
G
I
G
I
P
K
K
D
V
E
K
V
F
D
R
F
Y
R
V
D
------
L
G
G
T
G
L
G
L
A
I
A
K
E
M
V
Q
-
A
H
G
G
D
I
W
A
D
S
I
E
G
K
G
T
T
I
T
F
T
L
P
-
Y
K
E
---------
117
HHSearch
66.50
100%
-138
- C3 -
3SL2
2
A:
[5-153]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
R
F
M
S
L
I
I
D
---
R
F
E
M
------
T
K
-
E
Q
---------
E
F
I
R
-
N
L
P
D
R
D
L
Y
V
E
I
D
Q
D
K
I
T
Q
V
L
D
N
I
I
S
N
A
L
K
Y
S
P
E
G
G
H
V
T
F
-
S
I
D
V
N
E
E
E
E
L
L
Y
I
S
V
K
D
E
G
I
G
I
P
K
K
D
V
E
K
V
F
D
R
F
Y
R
V
D
------
L
G
G
T
G
L
G
L
A
I
A
K
E
M
V
Q
-
A
H
G
G
D
I
W
A
D
S
I
E
G
K
G
T
T
I
T
F
T
L
P
-
Y
K
E
---------
101
HHSearch
64.00
53%
33
- C3 -
4U7O
1
?
A:
[25-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
E
Q
Q
K
I
D
N
D
---------
R
K
Q
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
G
A
W
K
-
D
P
E
V
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
R
M
D
S
G
T
T
R
V
D
M
E
L
V
N
I
N
E
M
F
N
Y
V
L
D
---
R
F
D
M
------
I
L
K
K
D
DNPA
K
Y
--
Y
T
I
K
R
-
E
F
T
K
R
D
L
W
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
P
D
G
G
V
V
T
C
-
R
L
L
E
T
--
H
N
Q
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
-----
Q
G
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
-
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
-
Y
E
----------
4
PsiBlast_PDB
63.30
53%
44
- C3 -
4U7O
1
?
A:
[25-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
E
Q
Q
K
I
D
N
D
---------
R
K
Q
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
G
A
W
K
-
D
P
E
V
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
R
M
D
S
G
T
T
R
V
D
M
E
L
V
N
I
N
E
M
F
N
Y
V
L
D
---
R
F
D
M
I
L
KKDD
N
P
-
A
K
-----
Y
--
Y
T
I
K
R
-
E
F
T
K
R
D
L
W
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
P
D
G
G
V
V
T
C
-
R
L
--
L
E
T
H
N
Q
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
-----
Q
G
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
-
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
-
Y
E
----------
3
PsiBlast_PDB
55.21
53%
22
- C3 -
4U7N
-
?
A:
[386-610]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
G
A
W
K
-
D
P
E
V
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
R
M
D
S
G
T
T
R
V
D
M
E
L
V
N
I
N
E
M
F
N
Y
V
L
D
---
R
F
D
M
I
L
K
K
DD
N
---------
Y
--
Y
T
I
K
R
-
E
F
T
K
R
D
L
W
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
P
D
G
G
V
V
T
C
-
R
L
--
L
E
T
H
N
Q
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
-----------
T
G
L
G
L
A
I
S
K
E
V
V
Q
-
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
-
Y
E
----------
21
PsiBlast_CBE
54.51
53%
44
- C3 -
4U7O
1
?
B:
[37-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
G
A
W
K
-
D
P
E
V
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
------
T
R
V
D
M
E
L
V
N
I
N
E
M
F
N
Y
V
L
D
---
R
F
D
M
I
L
K
K
DD
N
P
-
A
K
-----
Y
--
Y
T
I
K
R
-
E
F
T
K
R
D
L
W
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
P
D
G
G
V
V
T
C
-
R
L
--
L
E
T
H
N
Q
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
A
R
---
Q
G
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
-
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
-
Y
E
----------
20
PsiBlast_PDB
50.52
41%
-224
- C2 -
4MN6
1
WALK_STAAU
A:
[6-106]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
H
M
S
D
G
I
I
A
T
D
R
R
G
R
I
R
I
V
N
D
M
A
L
K
M
L
G
M
A
K
E
D
I
I
G
Y
Y
M
L
S
V
L
S
L
E
D
E
F
K
-
L
E
E
I
--
N
N
D
S
F
L
L
D
L
--------
E
G
L
-
I
A
R
V
N
F
S
T
I
V
Q
E
T
G
F
-
V
T
G
Y
I
A
V
L
H
D
V
T
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
HHSearch
50.48
25%
-18
- C4 -
3A0R
1
?
A:
[9-348]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
E
S
I
L
E
S
L
E
T
A
I
I
T
L
S
K
D
G
R
I
T
E
W
N
K
K
A
E
Q
L
F
G
L
K
K
E
N
V
L
G
R
R
L
K
D
L
P
D
F
E
E
I
G
S
V
A
E
S
V
F
E
N
K
E
P
V
F
L
N
F
-
Y
K
-----
F
G
E
R
Y
F
N
I
R
F
S
P
F
R
N
A
K
T
Q
L
L
E
G
V
I
I
T
I
D
D
V
T
E
L
Y
K
Y
E
E
E
R
K
R
R
E
R
L
S
I
L
G
E
M
T
A
R
V
A
H
E
I
R
N
P
I
T
I
I
G
G
F
I
M
R
M
K
K
H
L
D
D
--
P
E
T
L
K
K
Y
I
N
I
I
T
N
E
L
S
R
L
E
T
I
V
K
E
I
L
E
Y
S
K
E
R
----
V
L
E
F
T
E
F
N
L
N
E
L
I
R
E
V
Y
V
---
L
F
E
E
------
K
I
R
K
M
-----
N
--
I
D
F
C
F
-
E
T
D
N
E
D
L
R
V
E
A
D
R
T
R
I
K
Q
V
L
I
N
L
V
Q
N
A
I
E
A
T
G
E
N
G
K
I
K
I
-
T
S
E
D
M
--
Y
T
K
V
R
V
S
V
W
N
S
G
P
P
I
P
E
E
L
K
E
K
I
F
S
P
F
F
T
T
------------
L
G
L
S
I
C
R
K
I
I
E
D
E
H
G
G
K
I
W
T
E
N
R
-
E
N
G
V
V
F
I
F
E
I
P
-
K
T
P
E
K
-------
8
PsiBlast_PDB
48.66
34%
50
- C3 -
4JAS
2
?
A:
[14-249]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
I
D
R
M
---------
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
V
I
K
G
Y
A
E
M
I
Y
N
S
L
G
E
L
D
L
S
T
L
K
E
F
L
E
T
I
I
E
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
F
A
S
------
S
H
-
N
V
-----
N
--
V
L
F
E
S
-
N
V
P
-
C
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
P
D
K
Y
V
K
V
I
L
D
E
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
-
K
D
R
---------
6
PsiBlast_PDB
48.58
35%
48
- C3 -
4JAV
6
?
A:
[14-248]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
I
D
R
M
---------
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
G
E
L
D
L
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
F
A
S
------
S
H
-
N
V
-----
N
--
V
L
F
E
S
-
N
V
P
-
C
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
P
D
K
Y
V
K
V
I
L
D
E
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
-
K
D
----------
23
PsiBlast_CBE
47.98
35%
62
- C3 -
3DGE
2
?
B:
[14-250]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
I
D
R
M
---------
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
G
E
L
D
L
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
V
E
S
A
V
N
AIK
E
F
A
S
------
S
H
-
N
V
-----
N
--
V
L
F
E
S
-
N
V
P
-
C
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
P
D
K
Y
V
K
V
I
L
D
E
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
-
K
D
R
A
--------
107
HHSearch
47.33
30%
4
- C3 -
4Q20
-
DIVL_CAUCR
A:
[537-758]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
R
L
---------
K
R
D
F
V
G
N
V
S
Y
E
L
R
T
P
L
T
T
I
I
G
Y
S
E
L
L
E
R
A
D
----
S
E
R
G
R
N
H
V
A
A
V
R
A
A
A
T
Q
L
A
R
S
I
D
D
V
L
D
M
A
Q
I
D
A
G
E
M
A
L
E
I
E
D
I
R
V
S
D
L
L
L
N
A
Q
E
---
R
A
L
K
------
D
A
Q
L
G
-----
G
--
V
T
L
A
V
-
E
C
E
E
D
V
G
L
I
R
G
D
G
K
R
L
A
Q
T
L
D
H
L
V
E
N
A
L
R
Q
T
P
P
G
G
R
V
T
L
-
S
A
R
R
A
--
L
G
E
V
R
L
D
V
S
D
T
G
R
G
V
P
F
H
V
Q
A
H
I
F
D
R
F
V
G
R
D
------
R
G
G
P
G
L
G
L
A
L
V
K
A
L
V
E
-
L
H
G
G
W
V
A
L
E
S
E
P
G
N
G
S
T
F
T
C
H
L
P
-
E
T
Q
---------
9
PsiBlast_PDB
47.21
34%
35
- C3 -
4JAU
1
?
A:
[14-247]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
I
D
R
M
---------
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
V
I
K
G
Y
A
E
M
I
Y
N
S
L
G
E
L
D
L
S
T
L
K
E
F
L
E
T
I
I
E
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
F
A
S
------
S
H
-
N
V
-----
N
--
V
L
F
E
S
-
N
V
P
-
C
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
P
D
K
Y
V
K
V
I
L
D
E
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
---------
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
-
K
-----------
10
PsiBlast_PDB
46.97
32%
17
- C3 -
4BIW
5
CPXA_ECOLI
A:
[70-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
A
L
E
R
M
M
T
S
---------
Q
Q
R
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
R
R
R
S
G
E
-
S
K
E
-----
L
E
R
I
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
Q
K
N
A
L
V
S
-
E
T
I
K
A
N
Q
L
W
S
E
V
L
D
---
N
A
A
F
------
E
A
-
E
Q
-----
M
--
G
K
S
L
T
V
N
F
P
P
G
P
W
P
L
Y
G
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
H
T
K
I
E
V
G
F
-
A
V
D
----
K
D
G
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
E
A
R
D
R
E
S
G
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
-
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
L
Y
K
----------
12
PsiBlast_PDB
46.81
32%
14
- C3 -
4BIY
3
CPXA_ECOLI
A:
[70-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
A
L
E
R
M
M
T
S
---------
Q
Q
R
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
R
R
R
S
G
E
-
S
K
E
-----
L
E
R
I
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
Q
K
N
A
L
V
S
-
E
T
I
K
A
N
Q
L
W
S
E
V
L
D
---
N
A
A
F
------
E
A
-
E
Q
-----
M
--
G
K
S
L
T
V
N
F
P
P
G
P
W
P
L
Y
G
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
H
T
K
I
E
V
G
F
-
A
V
D
----
K
D
G
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
---------
T
G
L
G
L
A
I
V
E
T
A
I
Q
-
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
L
Y
K
----------
25
PsiBlast_CBE
46.73
32%
20
- C3 -
4BIY
4
CPXA_ECOLI
C:
[70-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
A
L
E
R
M
M
T
S
---------
Q
Q
R
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
R
R
R
S
G
E
-
S
K
E
-----
L
E
R
I
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
Q
K
N
A
L
V
S
-
E
T
I
K
A
N
Q
L
W
S
E
V
L
D
---
N
A
A
F
------
E
A
-
E
Q
-----
M
--
G
K
S
L
T
V
N
F
P
P
G
P
W
P
L
Y
G
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
H
T
K
I
E
V
G
F
-
A
V
D
----
K
D
G
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
---------
T
G
L
G
L
A
I
V
E
T
A
I
Q
-
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
L
Y
K
----------
16
PsiBlast_PDB
46.65
32%
19
- C3 -
4CB0
6
CPXA_ECOLI
A:
[70-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
A
L
E
R
M
M
T
S
---------
Q
Q
R
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
R
R
R
S
G
E
-
S
K
E
-----
L
E
R
I
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
Q
K
N
A
L
V
S
-
E
T
I
K
A
N
Q
L
W
S
E
V
L
D
---
N
A
A
F
------
E
A
-
E
Q
-----
M
--
G
K
S
L
T
V
N
F
P
P
G
P
W
P
L
Y
G
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
H
T
K
I
E
V
G
F
-
A
V
D
----
K
D
G
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
E
A
R
D
R
E
S
G
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
-
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
L
Y
K
----------
11
PsiBlast_PDB
46.20
32%
15
- C3 -
4BIX
3
CPXA_ECOLI
A:
[70-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
A
L
E
R
M
M
T
S
---------
Q
Q
R
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
R
R
R
S
G
E
-
S
K
E
-----
L
E
R
I
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
Q
K
N
A
L
V
S
-
E
T
I
K
A
N
Q
L
W
S
E
V
L
D
---
N
A
A
F
------
E
A
-
E
Q
-----
M
--
G
K
S
L
T
V
N
F
P
P
G
P
W
P
L
Y
G
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
H
T
K
I
E
V
G
F
-
A
V
D
----
K
D
G
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
--------
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
-
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
L
Y
K
----------
28
PsiBlast_CBE
45.78
32%
18
- C3 -
4BIW
2
CPXA_ECOLI
B:
[70-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
A
L
E
R
M
M
T
S
---------
Q
Q
R
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
R
R
R
S
G
E
-
S
K
E
-----
L
E
R
I
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
Q
K
N
A
L
V
S
-
E
T
I
K
A
N
Q
L
W
S
E
V
L
D
---
N
A
A
F
------
E
A
-
E
Q
-----
M
--
G
K
S
L
T
V
N
F
P
P
G
P
W
P
L
Y
G
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
H
T
K
I
E
V
G
F
-
A
V
D
----
K
D
G
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
E
A
R
D
R
E
S
G
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
-
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
L
Y
K
----------
15
PsiBlast_PDB
45.26
32%
17
- C3 -
4BIV
2
CPXA_ECOLI
A:
[70-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
A
L
E
R
M
M
T
S
---------
Q
Q
R
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
R
R
R
S
G
E
-
S
K
E
-----
L
E
R
I
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
Q
K
N
A
L
V
S
-
E
T
I
K
A
N
Q
L
W
S
E
V
L
D
---
N
A
A
F
------
E
A
-
E
Q
-----
M
--
G
K
S
L
T
V
N
F
P
P
G
P
W
P
L
Y
G
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
H
T
K
I
E
V
G
F
-
A
V
D
----
K
D
G
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
E
A
R
D
R
E
S
G
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
-
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
L
Y
K
----------