@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0205: (2016-04-20 )
MSASLDDASVAPLVRKTAAWAWRFLVILAAMVALLWVLNKFEVIVVPVLLALMLSALLVPPVDWLDSRGLPHAVAVTLVLLSGFAVLGGILTFVVSQFIAGLPHLVTEVERSIDSARRWLIEGPAHLRGEQIDNAGNAAIEALRNNQAKLTSGALSTAATITELVTAAVLVLFTLIFFLYGGRSIWQYVTKAFPASVRDRVRAAGRAGYASLIGYARATFLVALTDAAGVGAGLAVMGVPLALPLASLVFFGAFIPLIGAVVAGFLAVVVALLAKGIGYALITVGLLIAVNQLEAHLLQPLVMGRAVSIHPLAVVLAIAAGGVLAGVVGALLAVPTVAFFNNAVQVLLGGNPFADVADVSSDHLTEV
Atome Classification :
(20 SA)
--------------.........10........20-------.........30........40........50........60........70........80..---------......90.-.......100.......110..-..-....120.---......130.......140...---....150.......160.......170.......180........190......---.200.......210.......220---.........230.......240--........250.......260.......270.......280........290.......300....-----------.---..310.......320...-...---.330.......340.......350.......360.....-----------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------MSASLDD
A
S
V
A
P
L
V
R
K
T
A
A
W
--------
A
W
R
F
L
V
I
L
A
A
M
V
A
L
L
W
V
L
N
KF
E
V
I
V
V
P
V
L
L
A
L
M
L
S
A
LLVPP
V
D
W
LDSRGL
P
H
A
V
A
V
T
L
V
L
L
S
G
---------
F
A
V
L
G
G
I
L
T
-
F
V
V
S
Q
F
I
AG
L
P
H
L
V
T
E
V
E
R
-
S
I
-
D
S
-
A
R
R
W
L
IEG---PAHLRGEQIDNA
G
N
A
A
I
E
A
L
RN---NQAKLTSGAL
S
T
A
A
T
I
T
E
L
V
T
A
A
V
L
V
L
F
T
L
I
F
F
L
YG-
G
R
S
I
W
Q
Y
V
T
K
AF
P
A
S
V
R
---
D
R
V
R
AAGR
A
G
Y
A
S
L
I
G
YA
R
A
T
F
-----
L
V
A
LTDAAGVGA
G
L
A
V
MGV
P
L
---
A
L
P
L
A
S
L
V
F
F
G
A
F
I
P
L
I
G
A
V
V
A
G
F
L
A
V
V
V
A
L
L
A
KGI
G
Y
A
L
-
I
T
V
G
L
L
I
A
V
N
Q
L
E
A
H
L
L
Q
P
L
V
MGRA-----------V---S
I
H
P
L
A
V
V
L
A
I
AA
G
G
V
L
A
-
G
V
V
---
G
A
L
L
A
V
P
T
V
A
F
F
N
N
A
V
Q
V
L
LGGNPFA
D
V
ADVSSDHLTEV-----------------------------------------------------------------------------------------------------------------
20
Fugue
95.02
16%
-127
- C3 -
4Q0W
4
RAD2_YEAST
A:
[1-362]
-------------G
V
H
S
F
W
D
I
A
G
P
T
A
R
P
V
R
L
E
S
L
--------
E
D
K
R
M
A
V
D
A
S
----
I
W
I
Y
Q
F
L
K
A
V
R
--------------------
D
Q
N
A
V
K
N
S
H
I
T
G
F
F
R
R
I
C
---------
K
L
L
Y
F
G
I
R
P
-
V
F
V
F
D
--
G
G
V
P
V
L
K
R
E
T
I
R
-
Q
R
-
K
E
-
R
R
Q
G
K
R
E
D
---
E
---
V
T
M
D
M
I
K
E
V
Q
E
L
L
S
R
F
G
I
---
P
Y
I
T
A
P
M
E
A
E
A
Q
C
A
E
L
L
Q
L
N
L
V
D
G
I
I
T
D
D
S
D
V
F
L
F
G
-
G
T
K
I
Y
K
N
M
F
H
E
-----
K
---
N
Y
V
E
F
Y
D
A
E
S
I
L
K
L
L
G
L
D
R
K
N
------
M
I
E
L
A
Q
L
L
G
S
D
Y
T
N
G
L
K
G
M
G
------
P
V
S
S
I
E
V
I
A
E
F
---------
G
N
L
K
N
F
K
D
W
Y
N
N
G
Q
F
D
K
R
-
K
Q
E
T
E
----
N
K
F
E
K
D
L
R
K
K
L
V
N
N
E
I
-----------
I
L
D
D
D
F
P
S
V
M
V
Y
D
A
Y
M
R
P
E
V
D
H
-
D
T
T
---
P
F
V
W
G
V
P
D
L
D
M
L
R
S
F
M
K
T
Q
L
G
W
P
-----
H
E
K
S
D
E
I
L
I
P
L
I----------------------------------------------------------------------------------------------------------------
17
Fugue
84.45
12%
-144
- C2 -
2BVL
8
TOXB_PEPDI
A:
[1-543]
MSLVN
R
K
Q
L
E
K
M
A
N
V
R
F
R
T
Q
E
D
E
Y
V
A
I
L
D
A
L
E
E
Y
H
N
MSENT
V
V
E
K
Y
L
K
L
K
D
I
N
S
L
T
D
I
C
I
D
T
Y
K
K
S
G
R
N
K
A
L
K
K
F
K
E
Y
L
V
T
E
V
L
E
L
K
N
N
N
L
T
P
V
E
K
N
L
H
F
V
W
I
G
G
QIN
D
T
A
I
N
Y
I
N
Q
W
K
D
V
N
S
D
Y
N
V
N
V
F
Y
D
S
N
A
F
L
I
N
T
L
K
K
-
T
V
V
E
S
-
A
I
N
D
T
L
E
S
F
RE
N
L
N
D
P
R
F
D
Y
N
K
F
F
R
K
R
M
E
I
I
Y
D
---
K
Q
K
N
F
I
N
Y
Y
K
A
Q
R
E
E
N
P
E
L
I
I
D
D
I
V
K
T
Y
L
S
N
E
Y
S
K
E
-
I
D
E
L
N
T
Y
I
E
E
S
L
N
K
I
T
Q
N
SG
N
D
V
R
N
F
G
E
F
K
N
G
E
S
F
N
L
Y
E
Q
E
L
VERWN
L
A
A
A
S
D
I
L
R
I
S
A
L
K
E
I
G
G
M
Y
L
D
VD
M
L
P
G
I
Q
P
D
L
F
E
S
I
E
K
P
S
S
V
T
V
D
F
W
E
M
T
K
L
E
A
I
M
K
Y
K
E
Y
I
P
E
Y
T
S
E
H
F
D
M
L
D
E
E
V
Q
S
S
F
E
S
V
L
A
S
K
S
DKSEIFSSL
G
D
M
---
E
A
S
P
L
E
V
K
I
A
F
N
S
K
G
I
I
N
Q
G
L
I
S
V
K
D
S
Y
C
S
N
L
I
V
K
Q
I
E
N
R
Y
K
I
L
N
N
S
L
N
P
A
I
S
E
D
N
D
F
N
T
T
T
N
T
F
I
D
S
I
M
A
E
ANADN
G
R
F
M
M
E
L
G
KYLRVGFFPDVK
T
T
I
N
L
SG
P
E
A
Y
A
A
A
Y
Q
D
L
L
M
FKEGSMNIHLI
E
A
D
L
R
N
F
EISKTNISQST
E
Q
E
M
A
SLWSFD
D
A
R
A
K
A
Q
F
E
E
Y
K
R
N
Y
F
E
GAL
13
Fugue
52.78
19%
-10
- C4 -
2MN4
-
?
A:
[1-94]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
P
E
Q
R
E
F
L
P
E
I
L
A
E
I
I
A
N
---
L
D
P
T
K
I
L
E
E
L
L
R
R
G
L
L
T
P
A
E
L
Q
E
V
L
D
L
K
T
---
P
E
E
Q
-
A
K
K
L
I
D
F
I
L
K
L
S
P
A
D
V
Q
---
A
R
I
N
V
L
R
A
H
G
Y
Q
A
L
A
D
K
L
N
K
Y
L
-----
T
L
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
Fugue
47.85
15%
-29
- C1 -
2MSX
-
SPIT1_HUMAN
A:
[47-160]
-------------------------------------------------------------------------------------------------------------------------
G
A
-
D
C
L
N
S
F
T
A
G
V
P
G
F
V
L
D
T
Q
A
-
S
V
-
S
N
--------
G
---
A
T
F
L
E
S
P
T
V
R
R
G
W
D
C
V
R
A
C
C
T
T
QNC
N
L
A
L
V
E
L
Q
P
D
R
G
E
D
A
I
A
A
C
F
L
I
N
C
L
Y
E
Q
N
F
V
C
K
F
A
P
-
R
E
G
F
I
N
Y
L
T
R
E
V
Y
R
S
Y
R
---
Q
L
V
D
H
H
H
H
H
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
Fugue
47.76
17%
43
- C4 -
4XIZ
-
MDM35_YEAST
M:
[1-70]
----------------------------------------------------------------------------------------------------------------------------------
S
A
S
F
A
P
E
C
T
D
L
K
T
-
K
Y
-
D
S
C
F
N
E
W
Y
S
E
K
-----
F
L
K
G
K
S
V
E
N
E
C
S
K
Q
W
Y
A
Y
T
T
---
C
V
N
A
A
L
V
K
Q
G
I
K
P
A
L
D
E
A
R
E
E
A
P
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
44.23
31%
13
- C4 -
3WAG
2
?
A:
[179-250]
---------------------------------------------------------------------------------
P
L
A
D
W
L
A
T
K
G
E
P
H
G
V
A
F
T
E
S
L
V
T
G
T
T
T
------
L
A
V
A
P
P
W
M
S
-
F
P
S
E
Q
P
A
L
S
M
R
H
L
P
F
N
G
P
A
-
V
L
-
P
D
----
W
L
R
E
A
---
P
S
R
P
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
Fugue
43.57
16%
80
- C4 -
2K37
-
CSMA_CHLTE
A:
[1-59]
-----------------------------------------------------------------------------------------------------------------------------------
M
S
G
G
G
V
F
T
D
I
L
A
-
A
A
-
G
R
-
I
F
E
V
M
V
E
G
---
H
W
E
T
V
G
M
L
F
D
S
L
G
K
G
T
M
R
I
N
R
N
---
A
Y
G
S
M
G
G
G
S
L
R
G
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
42.81
31%
11
- C4 -
3WAD
-
?
A:
[179-250]
---------------------------------------------------------------------------------
P
L
A
D
W
L
A
T
K
G
E
P
H
G
V
A
F
T
E
S
L
V
T
G
T
T
T
------
L
A
V
A
P
P
W
M
S
-
F
P
S
E
Q
P
A
L
S
M
R
H
L
P
F
N
G
P
A
-
V
L
-
P
D
----
W
L
R
E
A
---
P
S
R
P
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_CBE
42.60
31%
14
- C4 -
3WAG
2
?
B:
[179-250]
---------------------------------------------------------------------------------
P
L
A
D
W
L
A
T
K
G
E
P
H
G
V
A
F
T
E
S
L
V
T
G
TTT------
L
A
V
A
P
P
W
M
S
-
F
P
S
E
Q
P
A
L
S
M
R
H
L
P
F
N
G
P
A
-
V
L
-
P
D
----
W
L
R
E
A
---
P
S
R
P
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
Fugue
41.95
13%
114
* C4 *
1DEB
-
APC_HUMAN
A:
[1-54]
---------------------------------------------------------------------------------------------------------------------------------
A
A
A
S
Y
D
Q
L
L
K
Q
V
E
A
L
K
M
-
E
N
-
S
N
L
R
Q
E
L
E
---
D
N
S
N
H
L
T
K
L
E
T
E
A
S
N
M
K
E
V
L
K
Q
---
L
Q
G
S
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
HHSearch
37.11
12%
-139
- C- -
4CCT
-
?
D:
[20-53]
------------------
M
S
S
E
G
A
W
K
Q
I
Q
K
V
E
T
W
--------
A
L
G
H
P
G
F
T
V
I
A
L
F
L
A
H
A
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
HHSearch
31.92
11%
141
- C4 -
2OAR
-
MSCL_MYCTA
A:
[95-123]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
S
A
A
I
N
F
F
L
I
A
F
A
V
Y
F
L
V
V
L
P
Y
N
T
L
R
K
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
HHSearch
30.55
6%
-133
- C- -
4CBF
-
?
B:
[20-53]
------------------
M
S
S
E
G
A
W
K
H
A
Q
R
V
E
S
W
--------
I
L
R
N
P
G
F
A
L
L
A
G
F
M
A
Y
M
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
Fugue
27.05
30%
353
- C4 -
3TJ6
-
?
B:
[1-23]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
D
---
D
I
Y
N
K
A
R
E
V
I
N
A
V
N
P
V
I
E
A
L
E
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
HHSearch
26.06
9%
112
- C4 -
3J27
-
?
B:
[20-53]
------------------
M
S
S
E
G
A
W
K
H
A
Q
R
I
E
T
W
--------
I
L
R
H
P
G
F
T
I
M
A
A
I
L
A
Y
T
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
HHSearch
25.42
44%
408
- C4 -
5EH6
-
GLPA_HUMAN
A:
[75-90]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
I
F
G
V
I
A
-
G
V
I
---
G
T
I
L
L
---------------------------------------------------------------------------------------------------------------------------------------------------
6
HHSearch
18.94
13%
392
- C4 -
4OR5
2
AFF4_HUMAN
E:
[8-33]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
A
E
P
Y
K
VT-
S
K
E
D
K
L
S
S
R
I
Q
S
M
L
G
N
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
HHSearch
11.13
12%
226
- C4 -
2KV5
-
?
A:
[7-32]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
I
A
P
I
F
V
G
L
V
L
E
M
I
S
R
V
L
D
E
E
D
D
S
R
-----------------------------------------------------------------------------------------------------------------------------
5
HHSearch
9.55
8%
238
- C4 -
4B19
-
?
A:
[6-29]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
I
A
P
V
I
S
G
C
A
I
A
F
F
S
Y
W
L
S
R
R
N
T
-------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
4.49
7%
484
- C4 -
2L8S
-
A:
[27-41]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
A
L
W
K
I
G
F
F
K
R
P
L
K
------------------------------------------------------------------------------------------------------------------------------