@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0209: (2016-04-20 )
MRGQGHQIFVDELARFATSSADQRVVAIAQRAAEPLRVAVRGRPGVGCRTVARALQGAGSSSGMTVTPQARAADSDVDLVVYVTVEVVKPEDREAIAATRRPVVAVLNKADLAGPLSGAGPIVMAQARCAQFSTLLGVPMESMIGLLAVAALDDLDDTLRAVLRALAAHPDGFDALDRAVAGFLAAALPVPTEVRLRLLDTLDLFGIALGMAAFRPGRPSRTPAQLRTLLRRVSGVDAVIDKVTAAGSEVRYRRLLDAVAELEALAAQAKEIGGPIGEFLRDDDTVLARMAAAVDVALAVGLDVGPLDDPAAHLPRAVRWHRYSLDNGDMHRTCGADIARGSLRLWSLAGGMPLHRYRKSS
Atome Classification :
(20 SA)
---------------------------------------------------------------.........10.....---...20........30.--..------------.....40........50........60.---------------------.-----------------......70------------------.-----------------.--.--.--.----....80..----....--.--.--90.----.-..---.---.----.--.100--.....-...-110....---------...120.......130--.-....--...----140-....---------------...--..150.-----....--..160......--.--------170---......---------.------..180------....-----------...190----------........----200-..---.....210.......220.--......230.......240.......250.......260-........270----------.......280.......290...-------....300.....---..310.--......320.......---330.......340..-----...--..350.......360------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------------------------------------MRGQG
H
Q
I
F
V
D
E
L
A
R
F
---ATSSAD
Q
R
V
V
A
I
A
Q
RA--AE------------
P
L
R
V
A
V
RGRPGV
G
C
R
T
V
A
R
A
L
QGAGSSS---------------------
G
-----------------
M
T
VTPQA-------------------R-----------------A--A--D--S----DV
D
L
V
V
Y
V
----
T
V
E
V
--V--K--PE
D
----
R
-
E
A
---
I
---
A
----A--TRR---
P
V
V
A
V
-LNK-ADLAGPL---------SGAG
P
I
V
M
A
Q
A
R
C
A
Q
---
F
-
S
T
L
L--GV
P
----
M
---
E
S
M
I
---------------
G
L
L
--
A
V
A
A
L
D
-----
D
L
D
D
--
T
L
R
A
V
L
R
A
L
AA--H--------P-----D
G
F
D
A
L
---------
D
------
R
A
V
A
G
------
F
L
A
A
-----------ALPV
P
-----------
T
E
V
R
L
R
L
L
----
D
T
L
-
D
L
---
F
G
I
A
L
G
M
A
AFRPGRPSR
T
P
--
A
Q
L
R
T
L
L
R
R
VS
G
V
D
A
V
I
D
K
V
TAAG
S
E
V
R
Y
R
R
L
L
D
A
V
A
E
--
L
E
A
L
A
A
Q
A
K
EI----------GG
P
I
G
E
F
LRD
D
D
T
V
L
A
R
M
A
A
A
V
D
-------
V
A
L
A
VGLDVGPL---D
D
P
A
A
H
--
L
P
R
A
V
R
W
H
R
YSLDNGD---M
H
R
TCG
A
D
IARG
S
L
R
-----
L
W
S--LAGGMP
L
H
RYRKSS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
Fugue
88.07
19%
-84
- C9 -
4WZR
1
PUM3_HUMAN
A:
[9-524]
N
Y
D
I
V
V
R
A
K
Q
M
W
E
I
L
R
RKDCD
K
E
K
R
V
K
L
M
S
D
L
Q
K
L
I
QGK
I
K
T
I
A
F
AHDS
T
R
V
I
Q
C
Y
I
Q
Y
GN
E
E
Q
R
K
Q
A
F
E
E
L
R
D
D
L
V
E
L
---
S
K
A
K
Y
S
R
N
I
V
K
K
F
L
M
Y
GS
K
P
------------
Q
I
A
E
I
I
R
S
F
K
G
----
H
V
R
K
M
L
R
H
A
E
A
S
A
---------------------
I
-----------------
V
E
Y
A
Y
N
D
-------------------
K
-----------------
A
--
I
--
L
--
E
----
Q
R
N
M
L
T
E
E
LYG
N
T
F
Q
L
--
Y
--
K
--
S
A
D
HPT
L
D
-
K
V
---
L
---
E
----
L
--
Q
P
E
---
K
L
E
L
I
-
M
D
E
M
K
Q
I
L
T
P
M
---------
A
Q
K
E
A
V
I
K
H
S
L
V
H
K
V
---
F
-
L
D
F
F
--
T
Y
A
P
P
K
L
R
---
S
E
M
I
---------------
E
A
I
R
E
A
V
V
Y
L
A
-----
H
T
H
D
--
G
A
R
V
A
M
H
C
L
W
H
GT
P
--------
K
-----
D
R
K
V
I
V
---------
K
T
M
KTY
V
E
K
V
A
N
GQY
S
H
L
V
L
L
A
-----------
A
F
D
C
I
DD
T
K
L
V
K
Q
I
I
I
S
E
I
I
S
S
L
P
----
S
I
V
N
D
K
---
Y
G
R
K
V
L
L
Y
L
L
S
P
R
D
P
A
H
T
V
--
R
E
I
I
E
V
L
Q
K
G
D
G
-----
N
A
H
S
K
K
D
T
E
V
R
R
R
E
L
L
E
S
I
S
P
A
L
L
S
Y
L
Q
E
H
A
Q
E
V
V
L
DKSA
C
V
L
V
S
D
I
L
G
S
A
T
G
D
V
Q
P
T
M
N
A
I
A
S
L
A
A
-------
T
G
L
H
P
G
G
K
D
G
E
L
HIA
E
H
P
A
G
H
L
V
L
K
W
L
I
E
Q
D
K
K
M
K
E
N
G
R
EGC
F
A
K
T
L
V
E
H
V
G
M
K
N
L
K
-----
S
W
A
S
V
N
R
G
A
I
I
L
S
S
L
L
Q
S
C
D
L
E
V
A
N
K
V
K
A
A
L
KSLIPTLES
K
G
I
E
I
L
L
E
K
L------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
79.09
20%
-82
- C8 -
2WJG
1
FEOB_METJA
A:
[5-163]
----------------------------------------------------------------------------------------------------
M
K
------------
S
Y
E
I
A
L
I
G
N
P
N
V
G
K
S
T
I
F
N
A
L
T
G
E
N
V
Y
I
G
N
W
P
GVT
V
E
K
K
E
G
E
F
E
Y
NG
E
-
K
-----------------
F
K
V
V
D
L
P
GVYSLTANS
I
D
E
I
I
A
R
D
--
Y
-----------------
I
--
I
--
N
--
E
----
K
P
D
L
V
V
N
I
----
V
D
A
T
--
A
--
L
--
E
R
N
----
L
-
Y
L
T
L
Q
L
---
M
----
E
--
M
G
A
---
N
L
L
L
A
-
L
N
K
-
M
D
L
A
K
S
-------------
L
G
-
I
E
--
I
D
V
D
K
---
L
-
E
K
I
L
--
G
V
K
----
V
---
V
P
L
S
---------------
A
A
K
--
K
M
G
I
E
E
------
L
K
K
--
A
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
71.49
18%
-79
- C8 -
1MKY
3
DER_THEMA
A:
[2-182]
-------------------------------------------------------------------------------------------------------------------
A
T
V
L
I
V
G
R
P
N
V
G
K
S
T
L
F
N
K
L
V
K
-----DPV
Q
D
T
V
E
W
YG
K
---------
T
-----------------
F
K
L
V
D
T
C
GVFDNPQDIIS
Q
K
M
K
E
V
T
-
L
-----------------
N
--
M
--
I
--
R
----
E
A
D
L
V
L
F
V
----
V
D
G
K
RG
I
--
T
--
K
E
D
----
E
-
S
L
---
A
D
F
L
R
----
K
--
S
T
V
---
D
T
I
L
V
-
A
N
K
-
A
E
N
L
R
E
-------------
F
E
-
R
E
V
---
K
P
E
---
L
-
Y
S
L
G
--
F
G
E
----
P
---
I
P
V
S
---------------
A
E
H
--
N
I
N
L
D
T
------
M
L
E
--
T
I
I
K
K
L
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
Fugue
71.00
14%
-65
- C3 -
4WZI
5
PDE4B_HUMAN
A:
[85-576]
--------------------------------------------------------------------
V
T
P
F
A
Q
V
L
A
S
L
---
R
S
V
R
N
N
F
T
I
Q
K
L
A
M
E
T
--
L
E
------------
E
L
D
W
A
L
D
Q
L
E
T
I
Q
T
Y
R
S
V
S
E
M
A
S
N
K
F
K
R
---------------------
M
-----------------
L
N
R
E
L
T
H
-------------------
L
-----------------
S
--
E
M
S
R
--
C
----
G
N
Q
V
S
E
Y
I
----
S
N
T
F
--
L
--
D
--
K
E
N
----
E
-
D
H
---
L
---
A
----
K
--
E
L
E
---
D
L
N
K
W
G
L
N
I
-
F
N
V
A
G
-
Y
---------
S
H
N
R
P
L
T
A
I
M
Y
A
I
F
Q
E
R
D
L
-
L
K
T
F
--
R
I
S
----
S
---
D
T
F
I
---------------
T
Y
M
--
M
T
L
E
D
H
YHSDV
A
Y
H
N
--
S
L
H
A
A
D
V
A
Q
S
T
--
H
V
L
L
S
TPAL
D
-----
A
V
F
T
D
L
---------
E
------
I
L
A
A
I
------
F
A
A
A
I
H
DVDHPGVS
N
Q
F
L
I
N
-----------
T
N
S
E
L
A
L
M
Y
NDE
S
V
L
-
E
N
---
H
H
L
A
V
G
F
K
L
L
Q
E
E
H
A
D
-----
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
--
M
V
E
T
K
K
V
T
S
S
-----------
G
V
L
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
A
A
D
L
SNPTKS
L
E
L
Y
R
Q
W
T
D
R
I
M
---
E
E
F
F
Q
Q
--
G
D
K
E
R
E
R
G
M
E
I
S
P
M
A
D
---
K
H
T
A
C
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
--
T
W
A
D
L
V
Q
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
A
M
IP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
70.57
20%
-63
- C8 -
2WJI
3
FEOB_METJA
A:
[2-154]
-----------------------------------------------------------------------------------------------------
K
------------
S
Y
E
I
A
L
I
G
N
P
N
V
G
K
S
T
I
F
N
A
L
T
G
E
N
V
Y
I
GTVEKK
E
G
E
F
E
Y
NG
E
------
K
-----------------
F
K
V
V
D
L
P
GVYSLT-------------
A
NS
I
D
E
I
I
A
R
--------
D
Y
I
I
--
N
--
E
----
K
P
D
L
V
V
N
I
----
V
D
A
T
--
A
--
L
--
E
R
N
----
L
-
Y
L
T
L
Q
L
---
M
----
E
--
M
G
A
---
N
L
L
L
A
-
L
N
K
-
M
D
L
A
K
S
-------------
L
G
-
I
-
E
-
I
D
V
D
K
---
L
-
E
K
I
L
--
G
V
K
----
V
---
V
P
L
S
---------------
A
A
K
--
K
M
G
I
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
69.30
18%
-57
- C2 -
1E94
1
HSLU_ECOLI
E:
[7-449]
---------------------------------------------------------------
H
S
E
M
T
P
R
E
I
V
S
E
L
D
K
H
IIG
Q
D
N
A
K
R
S
V
A
I
A
L
R
N
R
W
--
R
R
MQLNEELRHEVT
P
K
N
I
L
M
I
G
P
T
G
V
G
K
T
E
I
A
R
R
L
A
K
L
A
N
A
P
---------------------
F
-----------------
I
K
V
E
A
T
K
-------------------
F
-----------------
T
--
E
--
V
--
G
YVGK
E
V
D
S
I
I
R
D
----
L
T
D
A
--
A
--
V
--
K
M
V
----
R
-
V
Q
---
A
---
I
----
E
--
K
N
R
---
Y
R
A
E
E
-
L
A
E
-
E
R
I
L
D
V
L
IPPAKNNWG
Q
T
E
Q
Q
Q
E
P
S
A
A
R
Q
A
F
---
R
-
K
K
L
R
--
E
G
Q
----
L
---
D
D
K
E
IEKQKARKLKIKDAM
K
L
L
--
I
E
E
E
A
A
-----
K
L
V
N
PE
E
L
K
Q
D
A
I
D
A
V
E
--
Q
--------
H
GIVFI
D
E
I
D
K
I
CKRGESSGP
D
------
V
S
R
E
G
------
V
Q
R
D
-----------
L
L
P
L
V
EGCT-------
V
S
T
K
H
G
M
V
----
K
T
D
-
H
I
---
L
F
I
A
S
G
--
A
F
Q
I
A
K
P
S
D
L
I
--
P
E
L
Q
G
R
L
P
I
R
V
E
L
Q
A
L
--------
T
T
S
D
F
E
R
I
L
T
E
P
N
A
----
S
I
T
V
Q
Y
K
A
L
----------
M
A
T
E
G
V
N
I
E
F
T
D
S
G
I
K
R
I
A
E
A
A
W
-------
Q
V
N
E
S
T
E
N
I
G
A
----
R
R
L
H
T
V
--
L
E
R
L
M
E
E
I
S
Y
D
A
S
D
L
S
----
G
Q
N
I
T
I
D
A
D
Y
V
S
K
H
-----
L
D
A
--
L
V
A
D
E
D
L
S
R
F
I
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
HHSearch
69.17
20%
-85
- C8 -
3IEV
3
ERA_AQUAE
A:
[10-229]
------------------------------------------------------------------------------------------------------------------
V
G
Y
V
A
I
V
G
K
P
N
V
G
K
S
T
L
L
N
N
L
L
G
T
K
V
S
I
I
S
PKA----------------
G
TTR
M
R
V
L
G
V
K
N
I
P
N
E
A
Q
I
I
F
L
D
T
P
G
I
Y
E
P
K
KSD
V
L
G
H
S
M
V
E
I
A
K
-----------------
Q
--
S
--
L
--
E
----
E
A
D
V
I
L
F
M
----
I
D
A
T
EG
W
--
R
--
P
R
D
----
E
-
E
I
---
Y
---
Q
N
FIK
P
--
L
N
K
---
P
V
I
V
V
-
I
N
K
-
I
D
K
I
G
P
A
------------
K
N
---
V
L
P
L
I
D
E
---
I
-
H
K
K
H
PE
L
T
E
----
I
---
V
P
I
S
---------------
A
L
K
--
G
A
N
L
D
E
------
L
V
K
--
T
I
L
K
Y
L
P
E
G
E
P
--
L
--------
F
-----
P
E
-
D
M
I
---------
T
------
D
L
P
L
R
------
L
L
----------------
A
A
-----------
E
I
V
R
E
K
A
M
----
M
L
T
-
R
E
EVP
T
S
I
A
V
K
I
N
E
I
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
66.39
19%
-73
- C8 -
3A1S
3
?
A:
[4-165]
-----------------------------------------------------------------------------------------------------
H
------------
M
V
K
V
A
L
A
G
C
P
N
V
G
K
T
S
L
F
N
A
L
T
G
T
K
Q
Y
V
A
N
W
P
GVT
V
E
K
K
E
G
V
F
T
Y
KG
Y
-
T
-----------------
I
N
L
I
D
L
P
GTY
S
L
G
Y
SS
I
D
E
K
I
A
----
R
-----------------
D
--
Y
L
L
K
--
G
----
D
A
D
L
V
I
L
V
----
A
D
S
V
--
N
--
P
--
E
Q
S
----
L
-
Y
L
---
L
L
E
I
L
----
E
--
M
E
K
---
K
V
I
L
A
-
M
T
A
-
I
D
E
A
K
K
-------------
T
G
-
M
--
K
I
D
R
Y
E
---
L
-
Q
K
H
L
--
G
I
P
----
V
---
V
F
T
S
---------------
S
V
T
--
G
E
G
L
E
E
------
L
K
E
--
K
I
V
E
Y
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
66.17
19%
-85
- C8 -
1MKY
3
DER_THEMA
A:
[178-353]
----------------------------------------------------------------------------------------------------
T
D
------------
A
I
K
V
A
I
V
G
R
P
N
V
G
K
S
T
L
F
N
A
I
L
N
K
E
R
A
L
VSPIPV
D
D
E
V
F
I
DG
R
------
K
-----------------
Y
V
F
V
D
T
A
GLEKYSN
Y
R
V
---------
V
-----------------
D
--
S
--
I
--
E
----
K
A
D
V
V
V
I
V
----
L
D
A
T
QG
I
--
T
--
R
Q
D
----
Q
-
R
M
---
A
---
G
L
M
E
-
R
--
R
G
R
---
A
S
V
V
V
-
F
N
K
-
W
D
L
V
V
H
R
---------
E
--
K
R
Y
D
E
F
T
K
L
F
R
E
---
K
L
Y
F
I
D
--
Y
S
P
----
L
---
I
F
T
S
---------------
A
D
K
--
G
W
N
I
D
R
------
M
I
D
--
A
M
N
L
A
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
65.83
18%
-82
- C8 -
1EGA
3
ERA_ECOLI
A:
[6-221]
----------------------------------------------------------------------------------------------------
S
Y
------------
C
G
F
I
A
I
V
G
R
P
N
V
G
K
S
T
L
L
N
K
L
L
G
Q
K
I
S
I
T
S
RKAQTTRHRIV
G
I
H
T
E
GA
Y
Q
-----------------
A
I
Y
V
D
T
P
GLH
M
E
E
K
R
A
I
N
R
L
M
NKAA-
S
-----------------
S
--
S
--
I
--
G
----
D
V
E
L
V
I
F
V
----
V
E
G
T
--
R
W-
T
--
P
D
D
----
E
-
M
V
---
L
---
N
K
L
R-
E
--
G
K
A
---
P
V
I
L
A
-
V
N
K
-
V
D
N
V
Q
E
-------------
K
A
--
D
L
L
P
H
L
Q
F
---
L
-
A
S
Q
M
N-
F
L
D
----
I
---
V
P
I
S
---------------
A
E
T
--
G
L
N
V
D
T
------
I
A
A
--
I
V
R
K
H
L
P
E
A
T
H
--
H
--------
F
-----
P
E
-
D
Y
I
---------
T
------
D
R
S
Q
R
------
F
----------------
M
A
S
-----------
E
I
I
R
E
K
L
M
----
R
F
L
-
G
A
ELP
Y
S
V
T
V
E
I
E
R
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
64.98
17%
-48
- C8 -
3B1V
3
?
A:
[3-159]
------------------------------------------------------------------------------------------------------------------
M
T
E
I
A
L
I
G
N
P
N
S
G
K
T
S
L
F
N
L
I
T
G
H
N
Q
R
V
GNWPGVTV
E
R
K
S
G
L
VKKNK--
D
-----------------
L
E
I
Q
D
L
P
G
IYSMSPYS
P
E
A
K
V
A
----
R
-----------------
D
--
Y
--
L
L
S
Q
----
R
A
D
S
I
L
N
V
----
V
D
A
T
--
N
--
L
--
E
R
N
----
L
-
Y
L
---
T
T
Q
L
I
----
E
--
T
G
I
---
P
V
T
I
A
-
L
N
M
-
I
D
V
L
D
G
-------------
Q
G
---
K
K
I
N
V
D
K
---
L
-
S
Y
H
L
--
G
V
P
----
V
---
V
A
T
S
---------------
A
L
K
--
Q
T
G
V
D
Q
------
V
V
K
--
K
A
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
64.88
22%
-78
- C8 -
1WF3
4
ERA_THET8
A:
[5-220]
----------------------------------------------------------------------------------------------------
T
Y
------------
S
G
F
V
A
I
V
G
K
P
N
V
G
K
S
T
L
L
N
N
L
L
G
V
K
V
A
P
I
S
PRPQTTR
K
R
L
R
G
I
L
T
E
GRR
Q
-----------------
I
V
F
V
D
T
P
GLHKPMD
A
L
G
E
F
M
D
Q
E
V
--
Y
-----------------
E
--
A
--
L
--
A
----
D
V
N
A
V
V
W
V
----
V
D
L
R
HP
P
--
T
--
P
E
D
----
E
-
L
V
---
A
R
A
L
K
----
P
LV
G
K
V
---
P
I
L
L
V
-
G
N
K
-
L
D
A
A
K
Y
-------------
P
E
-
E
-
A
M
K
A
Y
H
E
---
L
---
L
P
--
E
A
E
----
P
---
R
M
L
S
---------------
A
L
D
--
E
R
Q
V
A
E
------
L
K
A
--
D
L
L
A
L
M
P
E
G
P
F
--
F
Y-------
P
-----
E
D
Y
-
A
K
---------
S
------
D
Q
T
F
G
----------------------
E
W
V
A
-----------
E
I
L
R
E
E
A
M
----
K
R
L
-
W
H
EVP
Y
A
V
A
T
K
V
E
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
64.75
15%
-60
- C8 -
1G7S
1
IF2P_METTH
A:
[1-587]
---------------------------------MKIR
S
P
I
V
S
V
L
G
H
V
DHG
K
T
T
L
L
D
H
I
R
G
S
A
V
A
S
R
I
T
Q
H
I
G
A
T
E
I
P
M
D
---
V
I
E
G
I
C
G
D
F
L
K
K
F
S
I
R
--
E
T
------------
L
P
G
L
F
F
I
D
T
P
G
H
E
A
F
T
T
L
R
-------
K
R
---------------------
G
-----------------
G
A
L
A
------------------------------------------------------
D
L
A
I
L
I
V
D
----
I
N
E
G
--
F
--
K
--
P
Q
T
----
Q
-
E
A
---
L
---
N
----
I
--
L
R
M
Y
R
T
P
F
V
V
A
-
A
N
K
-
I
D
R
I
H
-------------------------
G
---
W
-
R
V
H
E
--
G
R
P
----
F
---
M
E
T
F
---------------
S
K
Q
--
D
I
Q
V
Q
Q
-----
K
L
D
T
--
K
V
Y
E
L
V
G
K
L
H
E
--
E
--------
G
-----
F
E
S
E
R
F
---------
D
------
R
-
V
T
D
------
F
A
S
Q
-----------
V
S
I
I
P
-----------
I
S
A
I
T
G
E
-----
G
I
P
-
E
L
---
L
T
M
L
M
G
L
A
Q
Q
Y
L
R
E
Q
L
K
I
E
--
E
D
S
-------
P
A
R
G
T
I
L
E
V
K
E
E
T
G
L
G
M
T
I
D
A
V
I
Y
D
------------------------------
G
I
L
R
K
D
D
T
I
A
M
M
T
S
K
D
V
I
S
-------
T
R
I
R
S
L
L
K
P
R
P
L
---
E
S
R
K
K
F
--
Q
K
V
D
----------------
E
V
V
A
A
A
G
I
K
I
V
A
P
G
-----
I
D
D
--
V
M
A
G
S
P
L
R
V
V
T
D
P
E
K
V
R
E
E
I
L
S
E
I
E
D
I
K
IDTD
E
A
G
V
V
V
K
A
DT
L
G
S
L
E
A
V
V
K
I
L
R
D
M
YVPIK
V
A
D
I
G
D
VS
R
R
D
V
V
N
A
G
I
A
L
Q
E
DRVYG
A
I
I
A
F
N
V
K
V
I
P
S
A
A
Q
E
L
KNSD
I
K
L
F
Q
G
NV
I
Y
R
L
M
E
E
Y
E
E
W
V
R
G
I
E
E
E
K
K
K
K
W
M
E
A
I
I
K
P
A
S
I
R
LIPKLVFRQSKP
A
I
G
G
V
E
V
LTGVIRQG
Y
P
L
M
N
DDGETVGTVESMQDKGENLKSASRGQKVA
M
A
I
K
DAVYGKTIHEG
D
T
L
Y
V
DIP
E
N
H
Y
H
ILKEQLLT
D
E
E
L
D
L
M
D
K
I
A
E
I
K
R
K
KNPD
26
HHSearch
64.71
19%
-73
- C8 -
3I8S
-
FEOB_ECOLI
A:
[2-163]
-----------------------------------------------------------------------------------------------------
K
------------
K
L
T
I
G
L
I
G
N
P
N
S
G
K
T
T
L
F
N
Q
L
T
G
S
R
Q
R
V
G
N
WAGVT
V
E
R
K
E
G
Q
F
S
T
TDH-
Q
-----------------
V
T
L
V
D
L
P
-------------------
G
TYSLTTTS
L
D
E
Q
I
A
C
H
Y
I
--
L
--
S
--
G
----
D
A
D
L
L
I
N
V
----
V
D
A
S
--
N
--
L
--
E
R
N
----
L
-
Y
L
T
L
Q
L
---
L
----
E
--
L
G
I
---
P
C
I
V
A
-
L
N
M
-
L
D
I
A
E
K
-------------
Q
N
---
I
R
I
E
I
D
A
---
L
-
S
A
R
L
--
G
C
P
----
V
---
I
P
L
V
---------------
S
T
R
--
G
R
G
I
E
A
------
L
K
L
--
A
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
64.60
22%
-74
- C8 -
3GEH
3
MNME_NOSS1
A:
[222-382]
----------------------------------------------------------------------------------------------------
R
T
------------
G
L
K
V
A
I
V
G
R
P
N
V
G
K
S
S
L
L
N
A
W
S
Q
S
D
R
A
I
VTDLPGTT
R
D
V
V
E
S
Q
L
V
V
GG
I
P
-----------------
V
Q
V
L
D
---------------------------------------
Q
--
A
--
A
--
N
----
T
A
D
L
V
L
L
T
----
I
D
A
A
--
T
GW
T
--
T
G
D
----
Q
-
E
I
---
Y
---
E
----
Q
V
-
K
H
R
---
P
L
I
L
V
-
M
N
K
-
I
D
L
V
E
K
-------------
Q
L
-
I
T
S
L
---
E
------
Y
P
E
N
--
I
T
Q
----
I
---
V
H
T
A
---------------
A
A
Q
--
K
Q
G
I
D
S
------
L
E
T
--
A
I
L
E
I
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
64.58
11%
-73
* C7 *
3JZ0
6
?
A:
[22-287]
------------------------------------------------------------------
L
K
Q
K
E
L
I
A
N
V
K
N
L
---
T
E
S
D
E
R
I
T
A
C
M
M
Y
-------------------------------------------
G
S
F
T
---------------------
K
-----------------
G
E
G
D
Q
Y
-----------------------------------------------
S
----
D
I
E
F
Y
I
F
L
----
K
H
S
I
--
T
--
S
--
N
F
D
----
S
-
S
N
---
W
---
L
----
F
--
D
V
A
---
P
Y
L
M
L
-
Y
K
N
-
E
Y
G
T
------------------
E
V
V
I
F
D
N
L
I
---
R
-
G
E
F
H
--
F
L
S
----
E
---
K
D
M
N
---------------
I
I
P
--
S
F
K
D
S
G
-----
Y
I
P
D
--
T
K
A
M
L
I
Y
D
--------------
E
-----
T
G
--
Q
L
---------
E
------
N
Y
L
S
E
------
I
S
G
A
-----------
R
P
N
R
L
-----------
T
E
E
N
A
N
F
L
----
L
C
N
-
F
S
---
N
L
W
L
M
G
I
N
V
L
K
R
G
E
Y
A
R
S
L
--
E
L
L
S
Q
L
Q
K
N
T
--
L
Q
L
I
R
M
A
E
K
N
A
D
N
W
L
N
M
S
K
N
L
E
K
E
I
S
--
L
E
N
Y
K
K
F
A
K
T
T
----------
A
R
L
------
D
K
V
E
L
F
E
A
Y
K
N
S
L
L
-------
L
V
M
D
L
Q
S
H
L
I
E
Q
---
Y
N
L
K
V
T
--
H
D
I
L
E
R
L
L
N
Y
I
S
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
62.95
21%
-54
- C8 -
3K53
-
?
A:
[2-155]
-----------------------------------------------------------------------------------------------------
V
------------
L
K
T
V
A
L
V
G
N
P
N
V
G
K
T
T
I
F
N
A
L
T
G
L
R
Q
H
V
G
N
W
P
GVT
V
E
K
K
E
G
I
M
E
Y
RE
K
-
E
-----------------
F
L
V
V
D
L
P
GIYSLTAHS
I
D
E
L
I
A
R
N
--
F
-----------------
I
--
L
--
D
--
G
----
N
A
D
V
I
V
D
I
----
V
D
S
T
--
C
--
L
--
M
R
N
----
L
F
L
T
---
L
E
L
F
E
----
M
--
E
V
K
---
N
I
I
L
V
-
L
N
K
-
F
D
L
L
K
K
-------------
K
G
-
A
--
K
I
D
I
K
K
---
M
-
R
K
E
L
--
G
V
P
----
V
---
I
P
T
N
---------------
A
K
K
--
G
E
G
V
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
Fugue
59.56
17%
-72
- C7 -
4WMA
4
XXLT1_MOUSE
A:
[7-305]
---------------------------------------------------------------
V
V
P
V
D
Y
H
L
L
M
M
F
T
K
A
E
---
H
N
A
P
L
Q
A
K
A
R
V
A
L
S
S
L
--
L
R
------------
L
A
K
F
E
A
H
E
V
L
N
L
H
F
V
S
E
E
A
S
R
E
V
A
K
A
L
L
---------------------
R
-----------------
E
L
L
P
P
A
A
-------------------
G
--------------------------------------
F
----
K
C
K
V
--
I
--
F
--
H
D
V
----
A
-
V
L
---
T
---
D
----
K
--
L
F
P
---
V
V
E
A
M
-
Q
K
Y
-
F
S
A
G
S
G
T
---------
Y
Y
S
D
S
I
F
F
L
S
V
A
M
H
Q
---
I
----
M
--
P
K
E
----
I
---
P
R
I
I
---------------
Q
L
--------------
D
L
D
L
--
K
Y
K
T
N
I
R
E
L
F
E
--
E
--------
F
-----
D
N
F
L
-----------
P
------
G
A
V
I
G
------
I
A
R
E
-----------
M
Q
P
V
Y
-----------
R
H
T
------------------------
F
W
Q
F
R
H
E
N
P
K
T
R
V
GD
P
P
P
E
G
L
P
G
F
N
S
G
V
--
M
L
L
N
L
E
A
M
R
Q
S
P
L
Y
S
H
L
L
E
-
P
S
W
--
V
Q
Q
L
A
D
K
Y
H
-
F
----------
R
G
H
L
G
------
D
Q
D
F
F
T
M
I
G
M
E
H
-------
P
E
L
F
H
V
L
D
-------
C
T
W
N
R
Q
--
L
C
T
W
W
R
D
H
G
Y
S
-
D
V
F
Q
---
A
Y
F
R
C
-----
E
G
H
V
K
-----
I
Y
H
--
G
N
C
N
T
P
I
P
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
58.90
24%
-47
- C8 -
4KYU
5
DER_BACSU
A:
[3-154]
------------------------------------------------------------------------------------------------------------------
K
P
V
V
A
I
V
G
R
P
N
V
G
K
S
T
I
F
N
R
I
A
G
E
R
I
------------------------RDRI
Y
S
S
A
E
W
LN
Y
D
---
F
N
L
I
D
T
G
GIDIGDEP
F
L
A
Q
I
R
Q
Q
A
--
E
-----------------
I
--
A
--
M
--
D
----
E
A
D
V
I
I
F
M
----
V
N
G
R
--
E
--
G
VT
A
A
D
----
E
-
E
V
A
K
I
L
---
Y
----
R
--
T
K
K
---
P
V
V
L
A
-
V
N
K
-
L
D
N
T
E
M
-------------
R
A
---
N
I
Y
---
D
---
F
-
Y
S
L
G
--
F
G
E
----
P
---
Y
P
I
S
---------------
G
T
H
--
G
L
G
L
G
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
57.99
27%
-43
- C8 -
2CEA
-
FTSH_THEMA
A:
[46-216]
-------------------------------------------------------------------------------------------------
A
--
R
M
------------
P
K
G
I
L
L
V
G
P
P
G
T
G
K
T
L
L
A
R
A
V
A
G
E
A
N
--------------------------------------------
V
P
F
F
-------------------
H
-----------------
I
--
S
--
G
--
S
----
D
F
-
V
E
L
F
V
----
G
V
G
A
--
A
--
R
--
V
R
D
----
L
-
F
A
---
Q
---
A
----
K
--
A
H
A
---
P
C
I
V
F
-
I
D
E
-
I
D
A
V
G
R
H
------------------
D
E
R
E
Q
T
---
L
-
N
Q
L
L
---
V
E
----
M
D
G
F
D
S
K
E
---------------
G
I
I
--
V
M
A
A
T
N
-----
R
P
D
I
--
L
D
P
A
L
L
R
---------------
P
-----
G
R
F
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------