@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0219: (2016-04-20 )
MFDIATRFKNSYGSGPLHLLAMVSGFALLGYIVATARPSALWNQATWWQSIAVWFVAAVVAHDLLLYPLYALADRILARLVGRRDVSAPRRRPELPVRNYIRIPALAAGLTLLVFLPGIIRQGAPTYLDATGQTQEPFLGRWLLLTAVAFGISAAAYAIRLVVAHVRRRRAGCSRVDAIDEE
Atome Classification :
(20 SA)
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.....------....10....-----....20..-------......30------.......--.--.40......----------------.--------.50.........60--.-----------.-......70-.........-------80---------...-.....90.----.......100.......110....-..---..120.....---..130--.......140.-----.......-------------------150.......160.......170-----..---.......180-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MF
D
I
A
------
T
R
F
KNSYGSG-----
P
L
H
L
L
A
M
V
-------
S
G
F
A
L
L
G
-------
Y
I
V
ATAR--
P
--
S
A
L
WNQ
A
T
W
----------------
W
--------
Q
S
-
I
A
V
W
F
V
A
A
V
V
A
--
H
-----------
D
-
L
L
L
Y
P
L
Y
--
A
L
A
D
R
I
L
A
R
-------
L
V---------GRR-DVSAPRRR----PELP
V
R
N
Y
IRI
P
A
L
A
A
G
L
T
-
L
L
V
F
-
L
P
---
G
I
I
RQGAP
T
Y
---LDATG--QTQE
P
F
L
G
R
-
W
-----
L
L
L
T
A
V
A
-------------------
F
G
I
S
A
A
A
Y
A
I
R
L
V
V
A
H
V
R
R
R
R-------AG---CSRVDAIDEE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
Fugue
76.60
18%
-130
* C7 *
4PAW
3
PYRE_HELPY
A:
[22-218]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
D
I
K
------
A
C
Y
Q
N
A
K
A
L
L
-----
E
G
H
F
L
-
L
S
-------
S
G
F
H
S
N
Y
-------
Y
L
----
Q
--
S
--
A
K
V
L
E
D
P
K
L
----------------
A
--------
E
Q
-
L
A
L
E
L
A
K
Q
I
Q
E
--
A
HLNI-------
E
-
C
V
C
S
P
A
I
GG
I
L
A
G
Y
E
L
A
R
-------
A
L
---------
G
V
R
-
F
I
F
T
E
R
V
D
----
N
T
M
A
L
R
R
G
F
E
V
K
K
N
E
-----
K
I
L
V
-
C
E
---
D
I
I
T
T
G
K
S
A
M
---
E
C
A
K
V
--
L
E
E
K
G
--
A
Q
-
I
-----
V
A
F
G
A
L
A
NRGI
C
K
R
A
HSH
L
K
A
Q
EGAC
L
P
S
H
L
P
L
F
A
L
E
D
F
V
F
D
M
H
K
P
S
SC-----
P
L
---
C
A
T
S
V
A
I
K
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
Fugue
67.47
26%
-83
* C6 *
4OV8
9
?
A:
[6-472]
DT
L
N
D
V
I
Q
D
P
T
R
R
N
K
L
I
N
D
N
NLL
K
G
I
I
M
GRD
G
P
V
P
S
SRELIVRPD
T
L
R
A
I
I
N
N
R
A
T
I
E
T
T
T
M
EAEFT
E
T
L
M
E
S
NYN
S
A
S
V
K
V
S
A
P
C
I
T
A
N
SEYSESSS
F
K
N
T
ET
E
K
S
M
Y
T
S
S
R
YLFPQ
G
R
I
D
F
T
T
PDSGD
V
I
K
L
S
P
Q
F
T
S
G
V
Q
A
A
L
A
KAT
G
T
E
K
R
E
A
L
Q
N
L
F
Q
E
YGCVFRT
K
V
H
I
G
G
V
L
S
A
H
T
M
E
T
F
S
RSEN
E
T
E
V
K
Q
D
V
K
A
G
L
E
G
A
V
K
G
W
G
G
GATAG
H
G
N
T
Q
------
G
T
I
T
T
S
Q
N
R
------
K
L
N
V
K
Y
I
V
-------
N
G
G
D
Y
T
K
--------
I
Q
N
T
E
E
--
W
--
V
A
S
T
N
Q
S
E
H
----------------
W
--------
R
V
-
I
E
V
T
E
V
T
A
V
A
---------------
D
-
L
L
P
Q
P
I
R
--
G
Q
V
K
D
L
L
K
P
-------
L
L
---------
G
K
W
V
D
V
E
K
V
P
G
L
----
E
S
L
P
V
S
V
Y
R
P
K
G
A
I
P
A
G
W
F
-
W
L
-------------------------
G
--
D
T
A
D
A
--
S
K
-
A
-----
L
L
V
K
P
T
L
-------------------
P
A
R
S
G
R
N
P
A
--
L
T
S
L
H
Q
G
S
G
M
-------
T
E
---
Q
P
F
V
D
L
P
Q
Y
Q
Y
L
S
TYFGSFAHDTPPGST
L
R
G
L
R
PDHV
L
P
G
R
Y
EMHGDTIST
A
V
Y
V
T
R
PVDVPFPE
D
E
A
F
DLK
S
L
V
R
VKLPGSGNPPKPR
S
A
L
K
KSMVLFD-------------------------------------------------------------------------------------------------------
98
Fugue
58.65
17%
-102
- C7 -
3D2Y
3
AMID_ECOLI
A:
[5-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EKG
I
V
E
K
E
G
Y
Q
L
D
------
T
R
R
Q
A
Q
A
A
Y
P
-----
R
I
K
V
L
V
I
H
Y
TADD
F
D
S
S
L
A
T
L
T
DKQVSSH
Y
L
V
P
A
V
P
--
P
--
R
Y
N
G
K
P
R
I
W
Q
LVPEQELAWHAGISA
W
RGATRLND
T
S
-
I
G
I
E
L
E
N
R
G
W
Q
--
K
S
AGVK
Y
F
A
P
F
E
P
-
A
Q
I
Q
A
L
I
--
P
L
A
K
D
I
I
A
R
Y
HIKPEN
V
V
---------
A
H
A
-
D
I
A
P
Q
R
K
D
----
D
P
G
P
L
F
P
W
Q
Q
L
A
Q
Q
G
I
G
A
W
-
P
D
A
Q
-
R
V
---
N
F
Y
L
A
G
R
A
P
H
---
T
P
V
D
T
--
A
S
L
L
E
L
L
A
R
-
Y
-----
G
Y
D
V
K
P
D
-------------------
M
T
P
R
E
Q
R
R
V
I
M
A
F
Q
M
H
F
R
P
T
L
YNGEAD
A
E
T
---
Q
A
I
A
E
A
L
L
E
K
YGQD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
Fugue
55.45
18%
-94
* C8 *
5A1S
10
?
A:
[16-448]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------SDLLRFKIFGMP
L
P
L
Y
A
F
A
L
I
T
L
L
L
S
H
F
Y
NAIPTD
L
V
G
G
F
A
L
M
F
V
M
G
A
I
F
G
E
I
G
K
R
L
------
P
I
F
N
K
Y
I
G
G
A
-----
P
V
M
I
F
L
V
A
-------
A
Y
F
V
Y
A
G
-------
I
F
T
Q
K
E
I
--
D
A
I
S
N
V
M
D
K
S
N
F
----------------
L
--------
N
L
F
I
A
V
L
I
T
G
A
I
L
S
V
N
R
-----------
K
-
L
L
L
K
S
L
L
--
G
Y
I
P
T
I
L
A
G
-------
I
V
---------
G
A
S
-
L
F
G
I
V
I
G
L
C
F
GI
P
V
D
R
I
M
M
L
Y
V
L
P
I
M
G
G
G
N
--------
G
---
A
G
A
V
P
L
S
E
I
Y
---
H
S
V
T
G
--
R
S
R
E
E
Y
Y
S
T
-
A
-----
I
A
I
L
T
I
A
-------------------
N
I
F
A
I
I
F
A
A
L
L
D
M
V
G
K
K
Y
T
W
L
-------
S
G
EGE
L
V
R
K
A
S
F
K
T
E
DD
E
K
A
G
QIT
H
R
E
T
A
V
G
M
V
L
S
T
T
C
F
L
L
A
Y
V
V
A
K
KILPSIGG
V
S
I
H
Y
F
A
W
M
V
L
I
V
A
A
L
N
A
S
GLCS
P
E
I
K
A
G
A
K
R
L
S
D
F
F
S
KQL
L
W
V
L
M
V
G
V
G
V
C
YTD
L
Q
E
I
I
D
A
LT
F
A
N
V
V
I
A
A
I
I
V
V
G
A
V
V
G
A
A
I
G
G
W
L
I
GFY
P
I
E
S
S
I
T
AGLCMANRG
G
S
G
D
L
E
V
L
S
A
C
NRMNL
I
S
Y
A
Q
I
S
S
R
L
G
G
G
I
V
L
V
I
A
S
I
V
F
S
M
M
V
L
E
94
Fugue
52.29
20%
-88
- C2 -
2X12
-
FAP1_STRPA
A:
[236-435]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T
K
T
T
F
T
I
S
DFSN
G
G
T
Q
Y
Y
W
A
G
G
N
A
N
N
L
K
N
P
I
S
S
I
S
A
V
-------
Y
D
S
A
T
-
G
-------
K
I
S
W
T
V
E
Y
D
P
--
T
T
I
L
K
S
P
A
L
----------------
K
--------
T
L
-
K
T
Y
T
G
I
Y
I
D
T
S
--
S
-----------
D
S
K
L
S
T
P
T
N
--
V
L
I
D
G
A
A
T
N
-------
P
V
T
NFYGNGSK
G
I
E
-
Y
V
S
K
G
T
T
K
G
V
--
T
K
H
T
I
T
F
D
T
A
F
S
G
R
A
N
D
L
A
D
L
E
I
K
M
L
A
---
A
T
T
L
S
D
P
H
F
Y
---
E
D
G
S
K
--
G
N
Y
G
R
Y
N
G
Q
T
A
-----
P
Y
V
I
A
N
D
-------------------
S
G
T
A
I
G
G
Y
Q
V
S
G
V
N
A
----------------------
D
S
I
P
S
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
51.55
30%
-63
- C5 -
3NKN
7
ENPP2_MOUSE
A:
[163-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
Y
M
R
----
P
V
Y
P
T
K
T
F
P
N
L
Y
T
L
A
T
G
L
-------
Y
P
ESH
G
I
V
--
G
N
S
M
Y
D
PV
F
D
A
T
F
H
L
R
G
R
E
K
F
N
H
R
-
W
WGGQP
L
W
I
T
A
T
K
-------------------
Q
G
V
R
A
G
T
F
F
W
S
V
S
I
P
H
E
R
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
51.49
30%
-64
- C5 -
4ZG6
8
ENPP2_HUMAN
A:
[183-312]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
Y
M
R
----
P
V
Y
P
T
K
T
F
P
N
L
Y
T
L
A
T
G
L
-------
Y
P
ESH
G
I
V
--
G
N
S
M
Y
D
PV
F
D
A
T
F
H
L
R
G
R
E
K
F
N
H
R
-
W
WGGQP
L
W
I
T
A
T
K
-------------------
Q
G
V
K
A
G
T
F
F
W
S
V
V
I
P
H
E
R
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
50.93
30%
-55
- C5 -
3NKM
7
ENPP2_MOUSE
A:
[163-249]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
Y
M
R
----
P
V
Y
P
T
K
T
F
P
N
L
Y
T
L
A
T
G
L
-------
Y
P
ESH
G
I
V
--
G
N
S
M
Y
D
PV
F
D
A
T
F
H
L
R
G
R
E
K
F
N
H
R
-
W
WGGQP
L
W
I
T
A
T
K
-------------------
Q
G
V
R
A
G
T
F
F
W
S
V
S
I
P
H
E
R
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
50.28
46%
-8
- C10 -
3RGT
-
DMGD_CHRSD
A:
[98-156]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
A
K
A
A
G
M
P
-
L
Y
Q
L
-
L
G
---
G
K
S
R
E
R
V
M
T
Y
---
A
H
C
T
G
--
Q
T
I
E
D
C
L
G
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
50.10
46%
-11
- C10 -
3QKE
1
DMGD_CHRSD
A:
[98-142]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
A
K
A
A
G
M
P
-
L
Y
Q
L
-
L
G
---
G
K
S
R
E
R
V
M
T
Y
---
A
H
C
T
G
--
Q
T
I
E
D
C
L
G
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
50.08
30%
-54
- C5 -
4ZG7
9
ENPP2_HUMAN
A:
[145-261]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
Y
M
R
----
P
V
Y
P
T
K
T
F
P
N
L
Y
T
L
A
T
G
L
-------
Y
P
ESH
G
I
V
--
G
N
S
M
Y
D
PV
F
D
A
T
F
H
L
R
G
R
E
K
F
N
H
R
-
W
WGGQP
L
W
I
T
A
T
K
-------------------
Q
G
V
K
A
G
T
F
F
W
S
V
V
I
P
H
E
R
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
49.97
46%
-12
- C10 -
4KWS
-
DMGD_CHRSD
A:
[98-142]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
A
K
A
A
G
M
P
-
L
Y
Q
L
-
L
G
---
G
K
S
R
E
R
V
M
T
Y
---
A
H
C
T
G
--
Q
T
I
E
D
C
L
G
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
49.86
30%
-60
- C5 -
4ZGA
5
ENPP2_HUMAN
A:
[199-338]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
Y
M
R
----
P
V
Y
P
T
K
T
F
P
N
L
Y
T
L
A
T
G
L
-------
Y
P
ESH
G
I
V
--
G
N
S
M
Y
D
PV
F
D
A
T
F
H
L
R
G
R
E
K
F
N
H
R
-
W
WGGQP
L
W
I
T
A
T
K
-------------------
Q
G
V
K
A
G
T
F
F
W
S
V
V
I
P
H
E
R
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
49.77
46%
-10
- C10 -
4K2S
1
DMGD_CHRSD
A:
[98-147]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
A
K
A
A
G
M
P
-
L
Y
Q
L
-
L
G
---
G
K
S
R
E
R
V
M
T
Y
---
A
H
C
T
G
--
Q
T
I
E
D
C
L
G
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
49.73
46%
-14
- C10 -
3PK7
-
DMGD_CHRSD
A:
[98-143]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
A
K
A
A
G
M
P
-
L
Y
Q
L
-
L
G
---
G
K
S
R
E
R
V
M
T
Y
---
A
H
C
T
G
--
Q
T
I
E
D
C
L
G
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
49.70
46%
-14
- C10 -
3QKE
1
DMGD_CHRSD
H:
[98-142]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
A
K
A
A
G
M
P
-
L
Y
Q
L
-
L
G
---
G
K
S
R
E
R
V
M
T
Y
---
A
H
C
T
G
--
Q
T
I
E
D
C
L
G
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
49.69
46%
-16
- C10 -
3OW1
1
DMGD_CHRSD
A:
[98-155]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
A
K
A
A
G
M
P
-
L
Y
Q
L
-
L
G
---
G
K
S
R
E
R
V
M
T
Y
---
A
H
C
T
G
--
Q
T
I
E
D
C
L
G
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
49.60
46%
-8
- C10 -
3QKE
1
DMGD_CHRSD
C:
[98-142]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
A
K
A
A
G
M
P
-
L
Y
Q
L
-
L
G
---
G
K
S
R
E
R
V
M
T
Y
---
A
H
C
T
G
--
Q
T
I
E
D
C
L
G
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
49.57
46%
-9
- C10 -
4K2S
2
DMGD_CHRSD
C:
[98-147]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
A
K
A
A
G
M
P
-
L
Y
Q
L
-
L
G
---
G
K
S
R
E
R
V
M
T
Y
---
A
H
C
T
G
--
Q
T
I
E
D
C
L
G
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
49.53
46%
-1
- C10 -
4K2S
1
DMGD_CHRSD
B:
[98-149]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
A
K
A
A
G
M
P
-
L
Y
Q
L
-
L
G
---
G
K
S
R
E
R
V
M
T
Y
---
A
H
C
T
G
--
Q
T
I
E
D
C
L
G
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------