@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0227c: (2016-04-20 )
MLRFAACGAIGLGAALLIAALLLSTYTTSRIAEIPLDIDATLISDGTGTALDSASLATEHIVVNQDVPLVSQQQVTVESPANADVVTLQVGSSLRRTDKQKDSGLLLAIVDTVTLNRKTAMAVSDDTHTGGAVQKPRGLNDENPPTAIPLRHDGLSYRFPFHTEKKTYPYFDPIAQKAFDANYEGEEDVNGLTTYRFTQNVGYTPEGKLVAPLKYPSLYAGDEDGKVTTSAAMWGLPGDPNEQITMTRYYAAQRTFWVDPVSGTIVKETERANHYFARDPLKPEVTFADYQVTSTEETVESQVNAARDERDRLALWSRVLPITFTAAGLVALVGGGLFASFSLRTEGALMAASGDRDDHDYRRGGFEEPVPGAEAETEKLPTQRPDFPREPSGSDPPRLGSAQPPPPPDAGHPDPGPPERR
Atome Classification :
(20 SA)
---------------------------------------.........10........20.------.......30-........40...--.....50....---....60........70........80.......---.90........100.......110.......120.......130.......140.......150.......160..-.-....----170..------.....180........190.......200.......210......--.220.......230----------.-......--..240....----...250-----------........260.-------.......270..------.....280-----.......290---------........300.......310.---......320.......330.......340.......350........360-----...-....370.......380.......390.......400.......410.......420------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------------MLRFAACG
A
I
G
L
G
A
A
L
L
I
A
A
L
L
------
L
S
T
YTTSR
I
-
A
EIPLDI
D
A
T
L
IS--DGTGTALDSAS---LA
T
E
H
I
V
VNQDVPLVSQ
Q
Q
V
T
VESPANA
D
V
V
T
L
---QVG
S
S
LRRTDKQKDS
G
L
L
L
A
I
V
D
T
V
TLNR
K
T
A
M
A
VSDDTHTGGAVQKPRGLNDENPP
T
A
I
P
L
RHDGLSYRFPFHTE-K-KTYP----YF
D
P
I
------
A
Q
K
AFDA-NYEGEEDVNG
L
T
T
Y
R
F
TQNVGYTPEG
K
L
V
A
P
LKYPSL--YAGDEDG
K
V
T
T
S
------------
A
-
A
MWGLP--GDPNE
Q
I
T
M
----
T
R
Y
Y
A
------------
A
Q
R
T
F
W
VDPV-S-------G
T
I
V
K
ETERANH------YFARDPLK-----PE
V
T
F
A
D
Y
Q
----------VT
S
T
E
E
T
V
E
S
Q
V
N
AAR
D
E
R
D
R
L
---
A
L
W
S
RVL
P
I
T
F
T
A
A
G
L
V
A
L
VGG
G
L
F
A
S
F
S
LRTE
G
A
L
M
A-ASGDRDD
H
D
Y
R-----RGG-FEEPVPGAEA
E
T
EKLPTQRPDFPREPSGSDPPRLGSAQPPPPPDAGHPDPGPPERR-------------
43
Fugue
95.02
19%
-14
- C4 -
4JY3
7
?
A:
[10-379]
-----------------------------------------
K
T
R
R
A
E
V
A
G
G
G
F
A
G
L
T
A
A
I
A
------
L
K
Q
N
-----------
G
W
D
V
R
L
H
E
--
K
S
S
E
L
R
A
F
G
A
G
---
I
Y
L
W
H
N
G
L
R
V
L
E
G
L
G
A
L
D
D
V
L
Q
G
S
H
T
P
P
T
Y
E
T
W
---
M
H
N
---
K
S
V
S
K
E
T
F
N
G
L
P
W
R
I
M
T
R
S
H
L
H
D
A
L
V
N
R
A
R
A
-----------
L
G
V
D
I
S
V
N
S
E
A
V
A
A
D
P
V
G
---
R
L
T
L
Q
T
G
-
E
-
V
L
E
A
DLIV
G
A
D
G
V
------
G
S
K
V
R
D
S
-
I
--------
G
F
K
Q
D
R
W
V
S
K
D
G
L
I
---
R
L
I
V
P
R
M
K
K
E
L
--
G
H
G
E
W
D
----
N
T
------------
I
-
D
M
W
N
F
W
--
P
R
V
Q
R
I
L
Y
S
PCNE
N
E
L
Y
L
------------
G
L
M
A
P
A
A
D
P
R
-
G
-------
S
S
V
P
I
D
L
E
V
W
V
E
------
M
F
--
P
F
L
E
-----
P
C
L
I
E
A
A
K
L
----------
K
T
A
R
Y
D
---------
K
Y
E
T
T
K
L
---
D
S
W
T
R
---------
G
K
V
A
L
V
G
D
A
A
H
A
M
C
P
A
L
A
Q
G
A
G
C
A
M
V
N
A
F
S
L
S
Q
D
L
E
-----
E
G
S
S
V
E
D
A
L
V
A
W
E
T
R
I
R
P
I
T
D
R
C
Q
A
L
S
G
D
Y
A
A
N
R
S
L
S
K
G
N
M
F
T
P
A
A
L
E
A
A
R
Y
D
P
L
R
R
V
Y
S
WPQ----------
38
Fugue
78.58
14%
0
- C8 -
2IQH
-
?
A:
[21-489]
---------------------------------NAT
E
I
R
A
S
V
G
K
M
I
D
G
I
G
R
F
Y
I
Q
M
C
T
E
L
K
------
L
S
D
Y
E
-
G
R
L
-
I
Q
N
S
L
T
I
E
R
M
V
L
S
A
F
D
T
G
G
P
I
Y
R
R
V
D
G
K
W
R
R
E
L
I
L
Y
D
K
E
E
I
R
R
I
W
R
Q
A
N
N
G
D
D
A
T
A
G
L
T
H
M
M
---
I
W
H
S
N
L
N
D
A
T
Y
Q
R
T
R
A
L
V
R
T
G
M
D
P
R
M
C
S
L
M
Q
G
S
T
L
P
R
R
S
G
A
A
G
A
A
V
K
G
-----------
V
G
T
M
V
M
E
L
I
R
M
I
K
R
G
I
N
-
R
-
R
T
R
I
----
A
Y
E
R
M
------
C
N
I
L
K
G
K
--
F
Q
T
A
A
Q
R
T
M
V
D
Q
V
R
E
S
R
N
P
G
N
A
E
F
E
D
L
I
F
L
A
R
S
A
L
I
--
L
R
G
S
V
A
H
K
S
C
L
P
------------
A
-
C
V
Y
G
S
A
--
V
A
S
G
Y
D
F
E
R
----
E
G
Y
----------------
S
L
V
G
I
D
P
F
-
R
L
L
Q
NSQ
V
Y
S
L
I
R
P
N
E
N
P
A
H
K
S
Q
L
V
W
M
A
C
H
S
A
A
F
-----
E
D
L
R
V
S
S
F
I
R
GTKVVPRGK
L
S
T
R
G
V
Q
I
A
S
N
E
N
M
E
T
M
E
S
S
T
L
---
E
L
R
S
R
Y
W
A
I
R
T
R
S
G
G
N
T
S
S
G
Q
I
S
I
Q
P
T
F
S
V
Q
------------
R
N
L
P
F
D
R
-----
P
T
I
-
M
A
A
S
D
M
R
T
E
I
I
R
L
M
E
S
A
R
P
E
D
V
S
F
Q
G
R
G
V
F
E
L
S
D
E
K
A
T
S
P
I
V
P
S
F
D
M
S
N
E
G
S
Y
F
F
--------------
39
Fugue
57.32
11%
17
- C5 -
1N67
3
CLFA_STAAE
A:
[28-359]
------------------------------------------------------------------------
G
T
D
I
-
T
N
Q
L
T
N
V
T
V
G
I
D
S
--
G
T
T
V
Y
P
H
Q
A
G
Y
---
V
K
L
N
Y
G
F
S
V
P
N
------------
S
A
V
K
G
D
T
F
K
I
---
T
V
P
K
E
L
N
L
N
G
V
T
S
--------------
T
A
K
V
P
P
I
M
A
G
D
Q
V
L
A
N
G
V
I
D
S
D
G
---------------
N
V
I
Y
T
F
T
D
Y
V
N
-
T
-
K
D
D
V
----
K
A
T
L
T
------
M
P
A
Y
I
D
------
P
E
N
V
K
K
T
G
N
V
T
L
A
T
G
I
G
-
S
T
T
A
N
K
T
V
L
V
D
Y
E
K
-----
Y
G
K
F
Y
N
L
S
I
K
------------
G
-
T
I
D
Q
I
D
--
K
T
N
N
-
T
Y
R
Q
----
T
I
Y
V
N
------------
P
S
G
----
D
N
V
-
I
-------
A
P
V
L
T
G
N
L
K
P
N
T
------
D
S
N
A
L
I
D
Q
-----
Q
N
T
S
I
K
V
Y
K
----------
V
D
N
A
A
D
L
S
E
S
Y
F
V
N
P
E
N
F
E
D
V
T
---
N
S
V
N
I
T
F
P
N
P
N
Q
Y
K
V
E
F
N
T
P
D
D
Q
I
T
T
P
Y
I
V
V
V
N
G
H
I
D
P
-
N
S
K
G
D
L
A
L
R
S
T
-----
L
Y
G
-
Y
N
S
N
------
I
I
W
R
S
M
S
W
D
N
E
V
A
F
N
N
G
S
G
S
G
D
G
I
D
K
P
V
V
P
E
Q
P
D
E
P
G
E
I
E
P
I
P
E
K
--------------
17
PsiBlast_PDB
55.11
24%
-6
* C11 *
3NZM
2
A:
[18-132]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
V
E
Y
G
P
L
P
I
G
K
I
V
S
E
E
I
N
C
S
V
--
Y
S
V
D
P
E
G
R
V
Y
T
Q
------------
A
I
A
Q
W
H
D
R
--
G
E
-----------------------------
Q
E
V
L
E
Y
E
L
E
-
D
-------
G
S
V
I
R
A
T
--
S
D
H
------
R
F
L
T
--------------
T
D
Y
Q
----------
L
L
A
I
E
E
I
F
A
R
Q
L
D
L
L
T
L
E
N
I
K
Q
TEE
A
L
D
N
H
R
L
P
F
P
L
L
D
A
G
T
I
K
M
V
------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
52.36
24%
-2
- C11 -
1ZDE
3
A:
[19-135]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
V
E
Y
G
P
L
P
I
G
K
I
V
S
E
E
I
N
C
S
V
--
Y
S
V
D
P
E
G
R
V
Y
T
Q
------------
A
I
A
Q
W
H
D
R
--
G
E
-----------------------------
Q
E
V
L
E
Y
E
L
E
-
D
-------
G
S
V
I
R
A
T
--
S
D
H
------
R
F
L
T
--------------
T
D
Y
Q
----------
L
L
A
I
E
E
I
F
A
R
Q
L
D
L
L
T
L
E
----------
N
H
R
L
P
F
P
L
L
D
A
G
T
I
K
M
V
------------------------------------------------------------------------------------------------------------
36
Fugue
51.99
7%
14
- C8 -
3DH4
4
?
A:
[52-518]
AGKSLPWW
A
V
G
A
S
L
I
A
A
N
ISAEQFI
G
M
S
G
S
G
Y
S
IGLAIA
S
Y
E
W
M
S
A
I
T
L
I
I
V
G
K
Y
F
L
P
I
F
I
E
K
GIYT
I
P
E
F
V
E
K
R
F
N
K
K
L
K
T
I
L
A
V
F
W
I
S
--
L
Y
I
F
V
N
L
T
S
V
L
---
Y
L
G
--
G
L
A
L
E
T
I
L
G
I
P
L
M
Y
S
I
L
G
L
A
L
F
A
L
V
Y
S
I
---
V
V
W
T
D
V
I
Q
V
F
F
L
V
L
G
G
F
M
T
T
Y
M
A
V
S
F
I
G
G
T
D
G
W
F
A
G
V
S
K
M
V
D
A
A
P
G
H
F
E
M
I
L
D
Q
S
N
P
Q
Y
M
N
L
P
G
I
A
V
L
I
G
G
L
W
V
A
N
-
L
-
Y
Y
W
G
----
F
N
Q
Y
I
------
I
Q
R
T
L
A
A
K
S
V
S
E
A
Q
K
G
I
V
F
A
A
F
L
K
L
I
V
P
F
L
V
V
L
P
G
I
A
A
Y
V
I
T
S
D
P
--
Q
L
M
A
S
L
G
D
I
A
A
T
NLPSAANADKA
Y
P
-
W
L
T
Q
F
L
--
P
V
G
V
K
G
V
V
F
----
A
A
L
A
A
------------
A
I
V
S
S
L
A
S
M
L
-
N
-------
S
T
A
T
I
F
T
M
D
I
Y
K
------
E
Y
I
S
P
D
S
G
-----
D
H
K
L
V
N
V
G
R
----------
T
A
A
V
V
A
L
I
I
A
C
L
I
A
P
M
L
G
G
I
G
Q
---
A
F
Q
Y
I
Q
E
Y
T
G
L
V
S
P
G
I
L
A
V
F
L
L
G
L
F
W
K
-
K
T
T
S
K
G
A
I
I
G
-
V
V
A
S
I
P
F
A
L
F
L
K
F
MPL
S
M
P
-
F
M
D
Q
M
L
Y
T
L
L
F
T
M
V
V
I
A
F
T
S
L
S
T
S
I
N
D
D
D
P
K
G
I
S
V
T
S
S
M
F
V
T
D
R
S
F
N
I
A
A
Y
G
I
M
I
V
L
A
V
L
Y
T
L
F
W
V
L
Y
K
21
HHSearch
50.62
16%
36
- C9 -
4Q4F
5
SCRB2_HUMAN
A:
[228-405]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
G
D
S
--
F
H
P
L
I
T
-
K
D
E
V
L
Y
----
V
F
P
S
D
------
F
C
R
S
V
Y
I
-
T
F
S
D
Y
E
S
V
Q
G
L
P
A
F
R
Y
K
V
P
A
--
E
I
L
A
N
-
T
S
D
N
A
G
F
C
I
PE
G
N
C
L
G
S
G
V
L
N
V
S
------------
I
-
C
K
N
G
A
P
I
I
M
S
F
P
H
F
Y
Q
A
----
D
E
R
F
V
S
A
I
EG
M
H
P
N
QED
H
E
T
F
V
D
I
N
P
L
-
T
-------
G
I
I
L
K
A
A
K
R
F
Q
I
------
N
I
Y
V
K
K
L
D
DFVET
G
D
I
R
T
M
V
F
P
----------
V
M
Y
L
N
E
S
V
H
I
D
K
E
T
A
S
R
L
K
S
M
I
-----------------------------------------------------------------------------------------------------------------------------------
40
Fugue
49.94
19%
-21
- C8 -
4JOI
-
TEN1L_HUMAN
C:
[2-119]
-----------------------------------------------------------
M
L
------
P
K
P
G
T
Y
Y
L
P
-
W
E
V
S
-------------
A
G
Q
V
P
D
G
S
T
---
L
R
T
F
G
R
L
C
L
Y
D
M
I
---
Q
S
R
V
T
L
M
A
Q
H
G
S
D
Q
H
Q
V
---
L
V
C
T
K
L
V
E
P
F
H
A
Q
V
-
G
S
L
Y
I
V
L
G
E
L
Q
H
Q
Q
D
R
G
S
V
V
K
A
R
V
L
T
C
-----
V
E
G
M
N
L
P
L
L
E
Q
A
I
R
E
Q
R
L
Y
K
Q
E
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
49.31
32%
13
- C10 -
2QXV
-
EED_MOUSE
A:
[383-428]
-----------------------------------------------------------------------------------------------------------------------------
L
E
V
E
D
P
H
K
A
K
C
T
T
L
T
H
H
K
C
G
A
A
I
R
Q
T
S
F
S
R
D
S
S
I
L
I
A
V
C
D
D
A
S
I
W
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
49.21
32%
33
- C10 -
3K27
1
EED_HUMAN
A:
[316-361]
-----------------------------------------------------------------------------------------------------------------------------
L
E
V
E
D
P
H
K
A
K
C
T
T
L
T
H
H
K
C
G
A
A
I
R
Q
T
S
F
S
R
D
S
S
I
L
I
A
V
C
D
D
A
S
I
W
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
49.01
32%
30
- C10 -
3IIW
1
EED_HUMAN
A:
[315-360]
-----------------------------------------------------------------------------------------------------------------------------
L
E
V
E
D
P
H
K
A
K
C
T
T
L
T
H
H
K
C
G
A
A
I
R
Q
T
S
F
S
R
D
S
S
I
L
I
A
V
C
D
D
A
S
I
W
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
48.65
32%
29
- C10 -
3JPX
1
EED_HUMAN
A:
[352-397]
-----------------------------------------------------------------------------------------------------------------------------
L
E
V
E
D
P
H
K
A
K
C
T
T
L
T
H
H
K
C
G
A
A
I
R
Q
T
S
F
S
R
D
S
S
I
L
I
A
V
C
D
D
A
S
I
W
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
48.56
32%
27
- C10 -
3IJ1
1
EED_HUMAN
A:
[315-360]
-----------------------------------------------------------------------------------------------------------------------------
L
E
V
E
D
P
H
K
A
K
C
T
T
L
T
H
H
K
C
G
A
A
I
R
Q
T
S
F
S
R
D
S
S
I
L
I
A
V
C
D
D
A
S
I
W
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
48.51
32%
31
* C10 *
3IJC
1
EED_HUMAN
A:
[315-360]
-----------------------------------------------------------------------------------------------------------------------------
L
E
V
E
D
P
H
K
A
K
C
T
T
L
T
H
H
K
C
G
A
A
I
R
Q
T
S
F
S
R
D
S
S
I
L
I
A
V
C
D
D
A
S
I
W
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
48.48
32%
29
- C10 -
3K26
1
EED_HUMAN
A:
[316-361]
-----------------------------------------------------------------------------------------------------------------------------
L
E
V
E
D
P
H
K
A
K
C
T
T
L
T
H
H
K
C
G
A
A
I
R
Q
T
S
F
S
R
D
S
S
I
L
I
A
V
C
D
D
A
S
I
W
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
48.39
32%
38
- C10 -
3IJ0
1
EED_HUMAN
A:
[315-360]
-----------------------------------------------------------------------------------------------------------------------------
L
E
V
E
D
P
H
K
A
K
C
T
T
L
T
H
H
K
C
G
A
A
I
R
Q
T
S
F
S
R
D
S
S
I
L
I
A
V
C
D
D
A
S
I
W
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
48.29
16%
36
- C9 -
3MH9
-
LPRG_MYCTU
C:
[118-211]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
W
S
D
F
G
P
A
A
D
I
Y
-
D
P
A
Q
----
V
L
N
P
D
TGLANV
L
A
N
F
A
D
A
-
K
A
E
G
R
D
T
I
N
G
Q
N
T
I
R
I
S
G
K
V
S
A
Q
A
V
N
Q
I
A
P
P
------------------
F
------------------
N
A
------------------
T
Q
P
------------
V
P
A
T
V
W
I
Q
E
T
G
D
-------
H
Q
L
A
Q
A
Q
L
D
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
48.15
32%
28
- C10 -
3JZH
1
EED_HUMAN
A:
[352-397]
-----------------------------------------------------------------------------------------------------------------------------
L
E
V
E
D
P
H
K
A
K
C
T
T
L
T
H
H
K
C
G
A
A
I
R
Q
T
S
F
S
R
D
S
S
I
L
I
A
V
C
D
D
A
S
I
W
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
48.10
32%
27
- C10 -
3JZG
1
EED_HUMAN
A:
[352-397]
-----------------------------------------------------------------------------------------------------------------------------
L
E
V
E
D
P
H
K
A
K
C
T
T
L
T
H
H
K
C
G
A
A
I
R
Q
T
S
F
S
R
D
S
S
I
L
I
A
V
C
D
D
A
S
I
W
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
47.76
32%
29
- C10 -
4X3E
1
EED_HUMAN
A:
[317-362]
-----------------------------------------------------------------------------------------------------------------------------
L
E
V
E
D
P
H
K
A
K
C
T
T
L
T
H
H
K
C
G
A
A
I
R
Q
T
S
F
S
R
D
S
S
I
L
I
A
V
C
D
D
A
S
I
W
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------