@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0231: (2016-04-20 )
MLLNPNHLTRKYPDRRSGEIMAATVDFFESRGKARLKHDDHERIWYSDFLDFVGRERIFASLLTPASYGADDCRWDTYRISEFAEIMGFYGLSYWYPFQVTALGLGPIWMSANEDAKRKAAAGLEAGEVFAFGLSEQTHGADVYQTDMILTPSDGGWTANGEKYYIGNANVARMVSTFGKIAGTPESQEYVFFVADSQHERYDLIKNVVNSQNYVANYALRDYPVTEADILHRGAEAFHAALNTVNVCKYNLGWGAIGMCTHALYESVTHAANRHLYGTVVTDFSHVRRLLTDAYVRLIAMKLVASRASDYMRSASAADRRYLLYSPLTKAKVTSEGERVITALWDVIAAKGVEKDTFFETVAREIGLLPRLEGTVHINIGLLGKFMPNYLFAPDSTLPVIPRRDDAADDAFLFAQGPTGGLGKVRFHDWRASFDTCAHLPNVALLREQVDVFAELLASATPDAAQQKDIDFAFGVGQLFANVPYAQLILEEARLSGVDEALIDEIFGVLVRDFNTHAVELHGRSATTAEQARFAMRMVRRPVHDPARYDQIWKDHVLALNGAYQMAP
Atome Classification :
(20 SA)
----------------------------------------.......--.-.10-.........----20........30...---....-.------40....-.--...50--.........60....-...-.70........80........90..--....--.--.100-........110.......120....--------..-.130.......140..--.--....150.--......160.....--..170.......180..-----..--...190--........200..----....--.--210-.---........220.......-230.....-------..240.......250.......260.......270.......280.......290.......300.......310...----------..-----.--------.-------320.-......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.-......450.......460.....--..470.......480.......490.......500.......510.......520.......530.......540.......550.......560......---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------MLL
N
P
N
H
--
L
-
T
R--KYPDRRSG
E
----
I
M
A
A
T
V
D
F
F
E
SRGKA---RLKH-D------DHER
I
W
-
Y
--
S
D
F
L
---
D
F
V
G
R
E
R
I
F
A
S
L
LTP-ASY-GADDCRW
D
T
Y
R
I
S
E
F
A
E
I
M
G
F
YGL
S
--
Y
W
Y
P
--
F
--
Q
V
-
T
-
A
LGLG
P
I
W
MSAN
E
D
A
K
R
K
A
AAGLEA--------G
E
-
V
F
A
F
GLSEQTHGA
D
V
Y
--
Q
--
T
D
M
I
L
TPS--DGGWTANG
E
K
Y
Y
IG--N
A
N
V
A
R
M
V
S
T
F
G
K
IAGT-----PE--S
Q
E
Y
V
---
F
F
V
ADSQ
H
E
R
Y
D
L
----
I
K
N
V
--V--N---S---Q
N
Y
V
A
NYALRDYPV
T
E
A
D
-
I
L
H
R
G
A
E
A
-------
F
H
A
A
L
N
T
V
N
V
C
K
YNLGW
G
A
I
G
M
C
T
H
A
L
Y
E
S
V
T
H
A
ANR
H
L
Y
G
T
VVT
D
F
S
H
V
R
R
L
L
T
D
A
Y
V
R
L
I
A
M
K
L
V
A
S
R
A
S
D
Y
M
R
SA----------SA-----A--------D-------
R
R
Y
L
-
L
YSPLTKAKVTSE
G
E
R
V
I
T
A
L
W
D
V
I
A
AKGVE
K
D
T
F
F
E
T
V
A
R
E
IGLLPRLE
G
T
V
H
I
N
I
G
L
L
G
KFMPNYLFAPDSTLPVIPRRDDAADD
A
F
L
F
A
QGPTGGLGK
V
R
F
H
D
WRAS
F
D
T
C
AHL
P
N
V
-
A
L
L
R
E
Q
V
D
V
F
A
E
L
L
A
SATPDAAQQ--KDI
D
F
A
F
G
V
G
Q
L
F
ANV
P
Y
A
Q
L
I
L
E
E
A
RLSGV
D
E
A
L
I
D
E
I
F
G
V
L
V
RDFNT
H
A
V
E
L
HGRSAT
T
A
E
Q
A
R
F
A
M
R
M
V
RRPVHD
P
A
R
Y
D
Q
I
W
K
D
H
V
L
A
LNGAYQMAP---
44
Fugue
90.06
19%
-64
- C2 -
2Z1Q
2
?
B:
[5-577]
-------------------------------KKLWQKGGG
W
L
L
E
V
P
E
R
V
Y
-
T
P
--
E
D
F
D
E
S
V
K
E
----
I
A
R
T
T
R
T
F
V
E
R
E
V
L
P
---
L
L
E
R
M
E
------
H
G
E
L
E
L
-
N
--
V
P
L
M
---
R
K
A
G
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L
G
L
L
A
-
I
D
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P
-
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Y
-
G
G
L
D
--
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K
V
I
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T
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V
A
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L
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S
G
G
F
--
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V
T
Y
--
G
--
A
H
-
T
-
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I
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L
P
L
V
Y
F
G
T
E
E
Q
K
R
K
Y
L
P
K
L
A
S
--------
G
E
W
I
A
A
Y
C
L
T
E
P
G
S
G
S
D
A
L
AA
K
--
T
R
A
T
L
S
E
D
--
G
K
H
Y
I
L
N
G
V
K
Q
W
I
S
--
N
A
G
F
A
H
L
F
T
V
F
A
K
V
D
G
-----------
E
H
F
T
---
A
F
L
V
E
R
D
T
P
G
L
S
F
----
G
P
E
E
--
K
--
K
---
M
GIK
A
S
S
T
R
Q
V
I
L
E
D
V
K
V
P
V
E
N
-
V
L
G
E
I
G
K
G
-------
H
K
I
A
F
N
V
L
N
V
G
R
Y
K
L
G
A
G
A
V
G
G
A
K
R
A
L
E
L
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A
Q
Y
A
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F
G
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P
I
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R
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A
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I
Y
A
A
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A
V
Y
R
T
V
G
L
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D
E
A
L
LGKKG
P
E
A
V
M
A
-----
G
--------
I
-------
E
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Y
A
-
V
E
A
S
I
I
K
V
L
G
S
E
V
L
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Y
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H
G
G
Y
G
Y
S
Q
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P
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R
A
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R
D
A
R
I
N
R
I
F
E
G
T
N
E
I
N
R
L
L
I
P
G
M
L
L
R
R
A
E
P
E
D
L
E
L
H
Q
V
Q
N
L
K
K
L
A
L
M
V
A
G
L
A
V
Q
K
Y
G
----------------
Q
G
V
E
E
E
Q
-
E
V
L
G
A
V
A
D
I
L
I
D
A
Y
A
A
E
S
A
L
L
R
A
R
--
R
L
G
G
----------------------
L
A
P
V
L
A
R
I
Y
L
A
Q
A
L
D
R
A
Q
A
G
A
L
S
V
L
P
R
L
V
E
G
D
E
A
R
V
V
Y
S
A
A
R
R
L
T
K
R
E
P
G
D
L
V
A
L
R
R
Q
A
A
E
A
V
L
E
A
--
G
G
Y
P
I
P
R
---
43
Fugue
86.28
16%
-70
- C2 -
2UXW
4
ACADV_HUMAN
A:
[21-607]
--------------------------------QSMS
F
A
V
G
M
F
K
G
Q
L
T
--
T
-
D
Q
VF
P
Y
P
S
V
L
N
-
E
----
E
Q
T
Q
F
L
K
E
L
V
E
P
V
S
R
---
F
F
E
E
-
V
ND
P
A
K
N
D
A
L
E
M
V
-
E
--
E
T
T
W
---
Q
G
L
K
E
L
G
A
F
-
G
L
Q
V
P
-
S
E
L
-
G
G
V
G
--
L
C
N
T
Q
Y
A
R
L
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I
V
G
M
H
D
L
G
--
V
G
I
T
--
L
--
G
A
-
H
Q
S
I
G
F
K
G
I
L
L
F
G
T
K
A
Q
K
E
K
Y
L
P
K
L
A
S
--------
G
E
T
V
A
A
F
C
L
T
E
P
S
S
G
S
D
A
A
SI
R
--
T
S
A
V
P
S
P
C
--
G
K
Y
Y
T
L
N
G
S
K
L
W
I
S
--
N
G
G
L
A
D
I
F
T
V
F
A
K
T
P
V
T
D
PATG
A
V
--
K
E
K
I
T
---
A
F
V
V
E
R
G
F
G
G
I
T
H
G
P
PE
K
K
M
G
--
I
--
K
---
A
---
S
N
-
T
A
E
V
F
F
D
G
V
R
V
P
S
E
N
-
V
L
G
E
V
G
S
G
-------
F
K
V
A
M
H
I
L
N
N
G
R
F
G
M
A
A
A
L
A
G
T
M
R
G
I
I
A
K
A
V
D
H
A
T
N
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T
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I
H
N
F
G
L
I
Q
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K
L
A
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M
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M
L
Q
Y
V
T
E
S
M
A
Y
M
V
S
A
N
M
D
Q
G
----------
A
-----------------------
T
D
F
Q
-
I
E
A
A
I
S
K
I
F
G
S
E
A
A
W
K
V
T
D
E
C
I
Q
I
M
G
G
M
G
F
M
K
E
P
G
V
E
R
V
L
R
D
L
R
I
F
R
I
F
E
G
T
N
D
I
L
R
L
F
V
A
L
Q
G
C
M
D
K
G
K
E
L
S
G
L
G
----------------
S
A
L
K
N
P
F
G
S
G
L
S
L
S
G
L
V
H
P
E
L
S
R
S
G
E
L
A
-
V
R
A
L
E
Q
F
A
T
V
V
E
A
K
L
I
K
H
K
K
G
I
V
N
--
E
-
Q
F
L
L
Q
R
L
A
D
G
A
I
D
L
Y
A
M
V
V
V
L
S
R
A
S
R
S
L
S
E
G
H
P
T
A
Q
H
E
K
M
L
C
D
T
W
C
I
E
A
A
A
R
I
R
E
G
M
A
A
L
Q
S
D
P
--------
W
Q
Q
E
L
Y
R
N
F
K
S
I
S
K
A
L
V
E
R
G
G
V
V
T
S
N
P
LGF
1
PsiBlast_PDB
80.74
20%
-73
- C2 -
5IDU
7
?
A:
[33-394]
---------------------------------------------------------------------
L
A
A
G
I
E
A
W
A
T
Q
H
L
A
---
C
V
Q
H
-
D
------
D
T
D
T
T
--
C
--
R
K
L
V
---
R
A
L
G
E
A
G
W
L
K
Y
G
V
G
G
-
A
Q
Y
-
G
G
H
G
D
T
I
D
T
R
A
V
C
L
L
R
E
T
L
A
N
H
D
G
L
--
A
D
F
A
--
L
--
A
M
-
Q
-
G
L
G
S
G
A
I
T
L
A
G
T
H
E
Q
K
I
R
Y
L
P
R
V
S
K
--------
G
E
A
I
A
A
F
A
L
S
E
P
D
A
G
S
D
V
A
--
A
--
M
S
L
Q
A
R
A
E
--
G
D
C
Y
V
I
D
G
D
K
T
W
I
S
--
N
G
G
I
A
D
F
Y
V
V
F
A
R
T
G
E
A
-----
P
G
--
A
R
G
I
S
---
A
F
I
V
D
A
D
T
P
G
L
Q
I
----
A
E
R
I
D
-
V
--
I
---
A
---
P
H
P
L
A
R
L
H
F
D
S
A
R
V
P
R
S
Q
-
M
L
G
A
P
G
E
G
-------
F
K
I
A
M
R
T
L
D
V
F
R
T
S
V
A
A
A
S
L
G
F
A
R
R
A
L
Q
E
G
L
A
R
A
A
S
R
K
M
F
G
Q
T
L
G
D
F
Q
L
T
Q
T
K
L
A
Q
M
A
L
T
I
D
S
S
A
L
L
V
Y
R
A
A
-
W
L
R
D
Q
----------
G
E
-----
N
--------
V
-------
T
R
----
E
A
A
M
A
K
W
H
A
S
E
G
A
Q
Q
V
I
D
A
A
V
Q
L
W
G
G
M
G
V
Q
S
G
T
T
V
E
R
L
Y
R
E
I
R
A
L
R
I
Y
E
G
A
T
E
V
Q
Q
L
I
V
G
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
79.86
19%
-76
- C2 -
5IDU
7
?
A:
[15-403]
------------------------------------------
I
D
P
H
G
--
A
L
A
W
--
P
F
F
E
A
R
H
R
E
----
L
A
A
G
I
E
A
W
A
T
Q
H
L
A
C
---
V
--
Q
-
H
------
D
D
T
D
T
T
-
C
--
R
K
L
V
---
R
A
L
G
E
A
G
W
L
K
-
Y
G
V
G
G
A
Q
Y
G
G
H
G
D
T
I
D
-
T
R
A
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C
L
L
R
E
T
L
A
N
H
D
G
L
--
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D
F
A
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L
--
A
M
-
Q
-
G
L
G
S
G
A
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T
L
A
G
T
H
E
Q
K
I
R
Y
L
P
R
V
S
K
--------
G
E
A
I
A
A
F
A
L
S
E
P
D
A
G
S
D
V
A
--
A
--
M
S
L
Q
A
R
A
E
--
G
D
C
Y
V
I
D
G
D
K
T
W
I
S
--
N
G
G
I
A
D
F
Y
V
V
F
A
R
T
G
E
A
-----
P
G
--
A
R
G
I
S
---
A
F
I
V
D
A
D
T
P
G
L
Q
I
----
A
E
R
I
--
D
--
V
I--
A
---
P
H
P
L
A
R
L
H
F
D
S
A
R
V
P
R
S
Q
-
M
L
G
A
P
G
E
G
-------
F
K
I
A
M
R
T
L
D
V
F
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T
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V
A
A
A
S
L
G
F
A
R
R
A
L
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L
A
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M
F
G
Q
T
L
G
D
F
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T
K
L
A
Q
M
A
L
T
I
D
S
S
A
L
L
V
Y
R
A
A
W
L
R
D
Q
G
----------
E
------------------------
N
V
T
-
R
E
A
A
M
A
K
W
H
A
S
E
G
A
Q
Q
V
I
D
A
A
V
Q
L
W
G
G
M
G
V
Q
S
G
T
T
V
E
R
L
Y
R
E
I
R
A
L
R
I
Y
E
G
A
T
E
V
Q
Q
L
I
V
G
R
D
L
L
K
A
H
A
A
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
79.23
19%
-63
* C2 *
1BUC
3
ACDS_MEGEL
A:
[1-383]
---------------------------------------------------
M
D
--
F
N
L
T
D
I
Q
Q
D
----
F
L
K
L
A
H
D
F
G
E
K
K
L
A
P
---
T
V
T
E
-
R
------
D
H
K
G
I
Y
D---
K
E
L
I
---
D
E
L
L
S
L
G
I
T
G
A
Y
F
E
E
-
K
Y
G
-
G
S
G
D
D
G
G
D
V
L
S
Y
I
L
A
V
E
E
L
A
K
Y
D
A
G
--
V
A
I
T
--
L
--
S
A
-
T
V
S
L
C
A
N
P
I
W
Q
F
G
T
E
A
Q
K
E
K
F
L
V
P
L
V
E
--------
G
T
K
L
G
A
F
G
L
T
E
P
N
A
G
T
D
A
S
--
G
--
Q
Q
T
I
A
T
K
N
D-
D
G
T
Y
T
L
N
G
S
K
I
F
I
T
--
N
G
G
A
A
D
I
Y
I
V
F
A
M
T
D
K
S
----------
K
G
N
H
G
I
T
A
F
I
L
E
D
G
T
P
G
F
T
Y
----
G
K
K
E
--
D
--
K
MGI
H
---
T
S
Q
T
M
E
L
V
F
Q
D
V
K
V
P
A
E
N
-
M
L
G
E
E
G
K
G
-------
F
K
I
A
M
M
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
A
A
L
A
D
A
V
E
Y
S
K
Q
R
V
Q
F
G
K
P
L
C
K
F
Q
S
I
S
F
K
L
A
D
M
K
M
Q
I
E
A
A
R
N
L
V
Y
K
A
A
C
K
K
Q
E
---------------------------
G
-------
K
P
F
T
-
V
D
A
A
I
A
K
R
V
A
S
D
V
A
M
R
V
T
T
E
A
V
Q
I
F
G
G
Y
G
Y
S
E
E
Y
P
V
A
R
H
M
R
D
A
K
I
T
Q
I
Y
E
G
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
V
Q
L
M
V
T
G
G
A
L
L
R
--------------------------
39
HHSearch
76.01
15%
-73
- C2 -
4P13
3
ACADM_HUMAN
A:
[5-384]
-------------------------------------------------------
F
E
F
T
E
Q
Q
K
E
----
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
---
V
A
A
E
-
Y
------
D
K
T
G
E
Y
-
P
--
V
P
L
I
---
R
R
A
W
E
L
G
L
M
N
-
T
H
I
P
-
E
N
C
G
G
L
G
L
G
T
F
---
D
A
C
L
I
S
E
E
L
A
Y
G
C
T
G
--
V
Q
T
A
--
I
--
E
G
-
N
-
S
L
G
Q
M
P
I
I
I
A
G
N
D
Q
Q
K
K
K
Y
L
G
R
M
T
E
--------
E
P
L
M
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
--
G
--
I
K
T
K
A
E
K
K
--
G
D
E
Y
I
I
N
G
Q
K
M
W
I
T
--
N
G
G
K
A
N
W
Y
F
L
L
A
R
S
D
P
D
PKA--
P
A
--
N
K
A
F
T
---
G
F
I
V
E
A
D
T
P
G
I
Q
I
----
G
R
K
E
L
N
M
--
G
Q--
R
---
C
S
D
T
R
G
I
V
F
E
D
V
K
V
P
K
E
N
-
V
L
I
G
D
G
A
G
-------
F
K
V
A
M
G
A
F
D
K
T
R
P
V
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
V
E
H
Q
A
I
S
F
M
L
A
E
M
A
M
E
V
E
L
A
R
M
S
Y
Q
R
A
A
W
E
V
D
S
G
----------
R
------------------------
R
N
T
-
Y
Y
A
S
I
A
K
A
F
A
G
D
I
A
N
Q
L
A
T
D
A
V
Q
I
L
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
S
Q
I
Q
R
L
I
V
A
R
E
H
I
D
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
74.70
19%
-72
- C2 -
2UXW
3
ACADV_HUMAN
A:
[45-451]
--------------------------------------------------------
V
L
N
E
E
Q
T
Q
F
L
K
E
L
V
E
P
V
S
R
F
F
E
E
V
N
D
P
---
A
K
---
N
------
D
A
L
E
M
V
-
E
--
E
T
T
W
---
Q
G
L
K
E
L
G
A
F
G
-
L
Q
V
P
-
S
E
L
G
G
V
G
L
C
N
T
---
Q
Y
A
R
L
V
E
I
V
G
M
H
D
L
G
--
V
G
I
T
--
L
--
G
A
-
H
Q
S
I
G
F
K
G
I
L
L
F
G
T
K
A
Q
K
E
K
Y
L
P
K
L
A
S
--------
G
E
T
V
A
A
F
C
L
T
E
P
S
S
G
S
D
A
A
--
S
--
I
R
T
S
A
V
P
S
PC
G
K
Y
Y
T
L
N
G
S
K
L
W
I
S
--
N
G
G
L
A
D
I
F
T
V
F
A
K
T
P
V
T
D
PATG
A
V
--
K
E
K
I
T
---
A
F
V
V
E
R
G
F
G
G
I
T
H
----
G
P
P
E
KK
M
--
G
I--
K
---
A
S
N
T
A
E
V
F
F
D
G
V
R
V
P
S
E
N
-
V
L
G
E
V
G
S
G
-------
F
K
V
A
M
H
I
L
N
N
G
R
F
G
M
A
A
A
L
A
G
T
M
R
G
I
I
A
K
A
V
D
H
A
T
N
R
T
Q
F
G
E
K
I
H
N
F
G
L
I
Q
E
K
L
A
R
M
V
M
L
Q
Y
V
T
E
S
M
A
Y
M
V
S
A
N
M
D
Q
G
----------
A
-----------------------
T
D
F
Q
-
I
E
A
A
I
S
K
I
F
G
S
E
A
A
W
K
V
T
D
E
C
I
Q
I
M
G
G
M
G
F
M
K
E
P
G
V
E
R
V
L
R
D
L
R
I
F
R
I
F
E
G
T
N
D
I
L
R
L
F
V
A
L
Q
G
C
M
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Fugue
74.67
15%
-69
- C2 -
4Y9J
4
ACD11_CAEEL
A:
[1-592]
TITARHTQYSHAKTGG
F
S
Q
T
G
P
TLHNPYKDDPI
L
D
R
T
L
R
R
L
L
P
E
S
E
Y
--
M
-
R
V
--
A
A
D
L
S
K
F
G
D
----
R
I
T
S
E
V
E
H
L
G
R
Q
A
E
L
E
Q
P
R
L
E
H
-
Q
------
D
A
W
G
K
R
-
V
--
D
K
L
I
V
C
N
E
W
H
K
L
K
Q
I
C
A
E
E
G
V
I
-
S
I
G
-
Y
E
D
S
V
D
P
F
V
R
R
I
H
Q
V
A
K
L
F
L
F
S
P
S
A
GL
V
S
C
P
--
M
--
A
M
-
T
-
D
G
A
V
K
T
L
T
S
L
N
L
Y
G
K
H
K
L
A
T
E
A
V
D
R
L
R
SRDPS
K
A
W
-
T
S
G
Q
W
M
T
E
K
K
G
G
S
D
V
A
--
G
GC
D
T
Y
A
V
Q
I
D
--
K
D
T
Y
R
L
H
G
Y
K
W
F
S
S
AV
D
A
D
V
A
L
T
L
A
R
I
V
D
S
D
G
N
-----
A
L
E
G
S
R
G
L
S
---
L
F
L
L
K
I
R
D
E
S
G
N
L
------
N
G
--
I
--
Q
---
M
---
V
R
L
K
N
K
L
G
T
K
Q
L
P
T
A
E
L
L
-
L
D
G
A
I
A
E
R
I
G
DQGR
G
V
A
G
I
S
N
M
L
N
I
T
R
I
H
N
A
V
A
S
L
G
Y
M
R
R
I
I
S
L
A
R
D
Y
S
T
K
R
V
V
F
G
Q
T
Q
S
K
W
P
L
H
T
T
T
L
A
K
M
E
V
D
T
R
G
S
M
L
L
L
F
E
A
A
R
L
L
G
L
S
----------
E
A
GKSS
D
V
--------
E
-------
A
M
M
L
R
L
I
T
P
V
L
K
L
Y
A
G
K
Q
A
V
P
M
V
S
E
G
I
E
C
F
G
G
Q
G
Y
M
E
D
T
G
L
P
T
L
L
R
D
A
Q
V
T
P
I
W
E
G
T
T
N
V
L
S
L
D
V
L
R
V
F
S
G
-----------------
K
E
N
I
L
L
A
F
G
K
R
V
E
Q
L
L
G
N
T
K
T
E
D
--------
E
K
L
K
K
S
K
E
A
V
E
S
A
L
K
Q
L
Q
K
L
L
V
K
A
S
D
S
A
I
Q
G
ET
R
I
D
S
V
A
R
H
I
A
F
T
I
A
R
I
Y
S
G
A
L
L
I
D
H
A
----------------------------
S
D
S
S
V
A
N
Q
S
D
I
E
V
A
Y
R
Y
C
C
E
Q
P
L
I
D
L
R
W
E
W
F
A
S
E
R
V
K
A
D
R
E
I
V
F
D
N
F
T--
35
HHSearch
73.76
19%
-70
- C2 -
2EBA
3
?
A:
[2-382]
------------------------------------------
L
D
F
Y
A
--
L
-
E
D
---
L
L
T
P
E
E
K
E
----
V
Q
K
A
A
R
R
F
L
E
K
E
A
L
P
---
H
I
R
D
-
W
------
W
E
E
G
V
F
-
P
--
T
H
L
I
---
P
R
F
A
E
L
G
F
L
G
-
P
T
L
P
-
P
E
Y
G
G
A
G
V
S
S
A
---
A
Y
G
L
I
C
Y
E
L
E
R
V
D
S
G
--
L
R
S
F
--
V
--
S
V
Q
S
-
S
L
V
M
Y
P
I
Y
A
Y
G
S
E
E
Q
K
R
E
F
L
P
K
L
A
R
--------
G
E
M
V
G
C
F
G
L
T
E
P
D
G
G
S
D
P
Y
G-
N
--
M
K
T
R
A
R
R
----
D
T
W
V
L
N
G
T
K
M
W
I
T
--
N
G
N
L
A
H
L
A
V
I
W
A
K
D
--------------
E
V
L
---
G
F
L
V
P
T
D
T
P
G
F
Q
A
----
R
E
V
K
RK
M
--
S
L--
R
---
A
S
V
T
S
E
L
V
L
E
E
V
R
V
P
E
S
L
-
R
L
P
K
A
-
L
G
-------
L
K
A
P
L
S
C
L
T
Q
A
R
F
G
I
A
W
G
A
M
G
A
L
E
A
V
Y
E
E
A
V
A
F
A
K
S
R
S
T
F
G
E
P
L
A
K
K
Q
L
V
Q
A
K
L
A
E
M
L
A
W
H
T
E
G
L
L
L
A
W
R
L
A
R
L
K
D
E
G
----------
K
------------------------
L
T
P
-
A
Q
V
S
L
A
K
R
Q
N
V
W
K
A
L
Q
A
A
R
M
A
R
D
I
L
G
G
S
G
I
T
L
E
Y
H
A
I
R
H
M
L
N
L
E
T
V
Y
T
Y
E
G
T
H
D
V
H
T
L
V
L
G
R
E
I
T
G
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
72.52
19%
-63
- C2 -
3OWA
6
?
A:
[29-431]
---------------------------------------------------
T
P
--
E
D
F
S
S
E
H
K
M
----
I
A
K
T
T
E
D
F
I
V
N
E
V
L
P
---
E
L
E
Y
-
L
------
E
Q
-
H
E
F
-
D
R
S
V
R
L
L
---
K
E
A
G
E
L
G
L
L
G
-
A
D
V
P
-
E
E
Y
G
G
I
G
L
D
K
V
---
S
S
A
L
I
A
E
K
F
S
R
A
G
-
G
--
F
A
I
T
--
H
--
G
A
H
V
-
G
I
G
S
L
P
I
V
L
F
G
N
E
E
Q
K
K
K
Y
L
P
L
L
A
T
--------
G
E
K
L
A
A
Y
A
L
T
E
P
G
S
G
S
D
A
L
--
G
--
A
K
T
T
A
R
L
N
AE
G
T
H
Y
V
L
N
G
E
K
Q
W
I
T
--
N
S
A
F
A
D
V
F
I
V
Y
A
K
I
D
G
-----------
E
H
F
S
---
A
F
I
V
E
K
D
Y
A
G
V
S
T
----
S
P
E
E
KK
M
--
G
I--
K
---
C
S
S
T
R
T
L
I
L
E
D
A
L
V
P
K
E
N
-
L
L
G
E
I
G
K
G
-------
H
I
I
A
F
N
I
L
N
I
G
R
Y
K
L
G
V
G
T
V
G
S
A
K
R
A
V
E
I
S
A
Q
Y
A
N
Q
R
Q
Q
F
K
Q
P
I
A
R
F
P
L
I
Q
E
K
L
A
N
M
A
A
K
T
Y
A
A
E
S
S
V
Y
R
T
V
G
L
F
E
S
R
----------
M
S
-----
T
LS
E
E
E
V
K
D
G
K
A
V
A
A
S
I
A
E
Y
A
-
I
E
C
S
L
N
K
V
F
G
S
E
V
L
D
Y
T
V
D
E
G
V
Q
I
H
G
G
Y
G
F
M
A
E
Y
E
I
E
R
M
Y
R
D
S
R
I
N
R
I
F
E
G
T
N
E
I
N
R
L
I
V
P
G
T
F
L
R
K
A
M
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
70.56
16%
-69
- C2 -
2IX5
5
ACOX4_ARATH
A:
[51-427]
---------------------------------------------------
F
N
--
D
L
L
T
P
E
E
Q
A
----
I
R
K
K
V
R
E
C
M
E
K
E
V
A
P
---
I
M
T
E
-
Y
------
W
E
K
A
E
F
-
P
--
F
H
I
T
---
P
K
L
G
A
M
G
V
A
G
-
G
S
I
--
K
G
Y
G
C
P
G
L
S
I
T
---
A
N
A
I
A
T
A
E
I
A
R
V
D
A
S
--
C
S
T
F
--
I
--
L
V
-
H
S
S
L
G
M
L
T
I
A
L
C
G
S
E
A
Q
K
E
K
Y
L
P
S
L
A
Q
--------
L
N
T
V
A
C
W
A
L
T
E
P
D
N
G
S
D
A
S
--
G
--
L
G
T
T
A
T
K
V
--
E
G
G
W
K
I
N
G
Q
K
R
W
I
G
--
N
S
T
F
A
D
L
L
I
I
F
A
R
N
T
T
----------
T
N
Q
I
N
---
G
F
I
V
K
K
D
A
P
G
L
K
A
----
T
K
I
P
NK
I
--
G
L--
R
---
M
V
Q
N
G
D
I
L
L
Q
N
V
F
V
P
D
E
D
-
R
L
P
G
V
N
-
S
-------
F
Q
D
T
S
K
V
L
A
V
S
R
V
M
V
A
W
Q
P
I
G
I
S
M
G
I
Y
D
M
C
H
R
Y
L
K
E
R
K
Q
F
G
A
P
L
A
A
F
Q
L
N
Q
Q
K
L
V
Q
M
L
G
N
V
Q
A
M
F
L
M
G
W
R
L
C
K
L
Y
E
T
G
----------
Q
------------------------
M
T
P
-
G
Q
A
S
L
G
K
A
W
I
S
S
K
A
R
E
T
A
S
L
G
R
E
L
L
G
G
N
G
I
L
A
D
F
L
V
A
K
A
F
C
D
L
E
P
I
Y
T
Y
E
G
T
Y
D
I
N
T
L
V
T
G
R
E
V
T
G
I
A
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
69.88
15%
-68
- C2 -
1RX0
8
ACAD8_HUMAN
A:
[10-392]
-------------------------------------------
T
S
C
I
--
D
-
P
S
--
M
G
L
N
E
E
Q
K
E
----
F
Q
K
V
A
F
D
F
A
A
R
E
M
A
P
---
N
M
A
E
-
W
------
D
Q
K
E
L
F
-
P
--
V
D
V
M
---
R
K
A
A
Q
L
G
F
G
G
-
V
Y
I
Q
-
T
D
V
G
G
S
G
L
S
R
L
---
D
T
S
V
I
F
E
A
L
A
T
G
C
T
S
--
T
T
A
Y
--
I
--
S
I
-
H
-
N
M
C
A
W
M
I
D
S
F
G
N
E
E
Q
R
H
K
F
C
P
P
L
C
T
--------
M
E
K
F
A
S
Y
C
L
T
E
P
G
S
G
S
D
A
A
--
S
--
L
L
T
S
A
K
K
Q
--
G
D
H
Y
I
L
N
G
S
K
A
F
I
S
--
G
A
G
E
S
D
I
Y
V
V
M
C
R
T
G
G
------
P
G
--
P
K
G
I
S
---
C
I
V
V
E
K
G
T
P
G
L
S
F
----
G
K
K
E
--
K
K
V
G
W--
N
---
S
Q
P
T
R
A
V
I
F
E
D
C
A
V
P
V
A
N
-
R
I
G
S
E
G
Q
G
-------
F
L
I
A
V
R
G
L
N
G
G
R
I
N
I
A
S
C
S
L
G
A
A
H
A
S
V
I
L
T
R
D
H
L
N
V
R
K
Q
F
G
E
P
L
A
S
N
Q
Y
L
Q
F
T
L
A
D
M
A
T
R
L
V
A
A
R
L
M
V
R
N
A
A
V
A
L
Q
E
E
----------
R
-----------------------
K
D
A
V
-
A
L
C
S
M
A
K
L
F
A
T
D
E
C
F
A
I
C
N
Q
A
L
Q
M
H
G
G
Y
G
Y
L
K
D
Y
A
V
Q
Q
Y
V
R
D
S
R
V
H
Q
I
L
E
G
S
N
E
V
M
R
I
L
I
S
R
S
L
L
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
69.82
20%
-58
- C2 -
3NF4
1
?
A:
[9-377]
---------------------------------------------
M
A
--
V
-
D
R
--
L
L
P
S
Q
E
A
A
E
----
L
I
E
L
T
R
E
I
A
D
K
V
L
D
P
---
I
V
D
R
-
H
------
E
K
D
E
T
Y
-
P
--
E
G
V
F
---
E
Q
L
G
A
A
G
L
L
-
S
L
P
Q
P
-
E
E
W
-
G
G
G
G
Q
P
Y
E
V
Y
-
L
Q
V
L
E
E
I
A
A
R
W
A
-
S
--
V
A
V
A
--
V
--
S
V
-
H
-
S
L
S
S
H
P
L
L
V
F
G
T
E
E
Q
K
K
R
W
L
P
G
M
L
S
--------
G
E
Q
I
G
A
Y
S
L
S
E
P
Q
A
G
S
D
A
A
--
A
--
L
R
C
A
A
T
P
T
--
D
G
G
Y
V
I
N
G
S
K
S
W
I
T
--
H
G
G
K
A
D
F
Y
T
L
F
A
R
T
G
-------
S
R
--
G
V
S
C
F
---
L
V
P
A
D
Q
P
G
L
S
F
G
K
----
P
E
E
K
--
M
--
G
---
L
---
H
A
V
P
T
T
S
A
F
Y
D
N
A
R
I
D
A
D
R
R
I
G
E
E
G
Q
G
-------
L
Q
I
A
F
S
A
L
D
S
G
R
L
G
I
A
A
V
A
T
G
L
A
Q
A
A
L
D
E
A
V
A
Y
A
N
E
------
K
I
I
D
H
-
G
L
G
F
L
L
A
------
D
M
A
A
A
V
A
T
A
R
A
T
Y
L
D
A
A
----------
R
R
-----
R
--------
D
Q
G-----
R
P
Y
S
-
Q
Q
A
S
I
A
K
L
T
A
T
D
A
A
M
K
V
T
T
D
A
V
Q
V
F
G
G
V
G
Y
T
R
D
Y
R
V
E
R
Y
M
R
E
A
K
I
M
Q
I
F
E
G
T
N
Q
I
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
69.30
14%
-68
- C2 -
3R7K
5
?
A:
[25-402]
---------------------------------------------------
P
E
--
A
W
T
T
P
E
R
R
A
----
L
S
Q
M
A
R
S
F
V
E
R
E
I
A
P
---
K
L
A
E
-
W
------
E
H
V
G
E
I
-
P
--
R
D
L
H
---
L
N
A
A
E
V
G
L
L
G
-
I
G
F
P
-
E
E
V
G
G
S
G
G
N
A
I
---
D
S
A
L
V
T
E
A
I
L
A
A
G
G
S
--
T
G
V
C
--
A
A
L
F
T
-
H
-
G
I
A
L
P
H
I
A
A
N
G
S
D
A
L
I
E
R
Y
V
R
P
T
L
A
--------
G
K
M
I
G
S
L
G
V
T
E
P
G
A
G
S
D
V
A
--
N
--
L
R
T
R
A
V
R
E
--
G
D
T
Y
V
V
N
G
A
K
T
F
I
T
--
S
G
V
R
A
D
F
V
T
T
A
V
R
T
G
G
------
P
G
--
Y
G
G
V
S
---
L
L
V
I
D
K
N
S
P
G
F
E
V
----
S
R
R
L
DK
M
--
G
W--
R
---
C
S
D
T
A
E
L
S
F
V
D
V
R
V
P
A
D
N
-
L
V
G
A
E
N
S
G
-------
F
L
Q
I
M
Q
Q
F
Q
A
E
R
L
G
I
A
V
Q
A
Y
A
T
A
G
R
A
L
D
L
A
K
S
W
A
R
E
R
E
T
F
G
R
P
L
T
G
R
Q
I
I
R
H
K
L
A
E
M
A
R
Q
V
D
V
A
C
T
Y
T
R
A
V
M
Q
R
W
L
A
G
----------
E
------------------------
D
V
V
-
A
E
V
S
M
A
K
N
T
A
V
Y
A
C
D
Y
V
V
N
E
A
V
Q
I
F
G
G
M
G
Y
M
R
E
S
E
I
E
R
H
Y
R
D
C
R
I
L
G
I
G
G
G
T
N
E
I
M
N
E
V
I
A
K
R
I
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
67.98
15%
-70
- C2 -
2PG0
2
?
A:
[8-383]
-------------------------------------------------------
R
Y
L
R
E
E
H
H
M
----
F
R
A
A
F
R
K
F
L
E
K
E
A
Y
P
---
H
Y
N
D
-
W
------
E
K
R
G
I
I
-
P
--
R
S
F
W
---
A
K
M
G
E
N
G
F
L
C
-
P
W
V
D
-
E
K
Y
G
G
L
N
A
D
F
A
---
Y
S
V
V
I
N
E
E
L
E
K
V
G
S
S
--
L
V
G
I
--
G
--
L
H
-
N
-
D
I
V
T
P
Y
I
A
S
Y
G
T
E
E
Q
K
Q
K
W
L
P
K
C
V
T
--------
G
E
L
I
T
A
I
A
M
T
E
P
G
A
G
S
D
L
A
--
N
--
I
S
T
T
A
V
K
D
--
G
D
Y
Y
I
V
N
G
Q
K
T
F
I
T
--
N
G
I
H
A
D
L
I
V
V
A
C
K
T
D
P
Q
AK---
P
P
--
H
R
G
I
S
---
L
L
V
V
E
R
D
T
P
G
F
T
R
----
G
R
K
L
--
E
KV
G
L--
H
---
A
Q
D
T
A
E
L
F
F
Q
D
A
K
V
P
A
Y
N
-
L
L
G
E
E
G
K
G
-------
F
Y
Y
L
M
E
K
L
Q
Q
E
R
L
V
V
A
I
A
A
Q
T
A
A
E
V
M
F
S
L
T
K
Q
Y
V
K
Q
R
T
A
F
G
K
R
V
S
E
F
Q
T
V
Q
F
R
L
A
E
M
A
T
E
I
A
L
G
R
T
F
V
D
R
V
I
E
E
H
M
A
G
----------
K
------------------------
Q
I
V
-
T
E
V
S
M
A
K
W
W
I
T
E
M
A
K
R
V
A
A
E
A
M
Q
L
H
G
G
Y
G
Y
M
E
E
Y
E
I
A
R
R
Y
R
D
I
P
V
S
A
I
Y
A
G
T
N
E
M
M
K
T
I
I
A
R
Q
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
67.77
15%
-71
- C2 -
2JIF
9
ACDSB_HUMAN
A:
[26-402]
----------------------------------------------------
L
--
Q
T
F
T
D
E
E
M
M
----
I
K
S
S
V
K
K
F
A
Q
E
Q
I
A
P
---
L
V
S
T
-
M
------
D
E
N
S
K
M
-
E
--
K
S
V
I
---
Q
G
L
F
Q
Q
G
L
M
G
-
I
E
V
D
-
P
E
Y
G
G
T
G
A
S
F
L
---
S
T
V
L
V
I
E
E
L
A
K
V
D
A
S
--
V
A
V
F
--
C
--
E
I
Q
N
-
T
L
I
N
T
L
I
R
K
H
G
T
E
E
Q
K
A
T
Y
L
P
Q
L
T
T
--------
E
K
-
V
G
S
F
C
L
S
E
A
G
A
G
S
D
S
F
--
A
--
L
K
T
R
A
D
K
E
--
G
D
Y
Y
V
L
N
G
S
K
M
W
I
S
--
S
A
E
H
A
G
L
F
L
V
M
A
N
V
D
P
T
-----
I
G
--
Y
K
G
I
T
---
S
F
L
V
D
R
D
T
P
G
L
H
I
----
G
K
P
E
NK
L
--
G
L--
R
---
A
S
S
T
C
P
L
T
F
E
N
V
K
V
P
E
A
N
-
I
L
G
Q
I
G
H
G
-------
Y
K
Y
A
I
G
S
L
N
E
G
R
I
G
I
A
A
Q
M
L
G
L
A
Q
G
C
F
D
Y
T
I
P
Y
I
K
E
R
I
Q
F
G
K
R
L
F
D
F
Q
G
L
Q
H
Q
V
A
H
V
A
T
Q
L
E
A
A
R
L
L
T
Y
N
A
A
R
L
L
E
A
G
----------
K
------------------------
P
F
I
-
K
E
A
S
M
A
K
Y
Y
A
S
E
I
A
G
Q
T
T
S
K
C
I
E
W
M
G
G
V
G
Y
T
K
D
Y
P
V
E
K
Y
F
R
D
A
K
I
G
T
I
Y
E
G
A
S
N
I
Q
L
N
T
I
A
K
H
I
D
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
66.53
16%
-68
- C2 -
1IVH
5
IVD_HUMAN
A:
[6-392]
---------------------------------------------
V
D
--
D
-
A
I
--
N
G
L
S
E
E
Q
R
Q
----
L
R
Q
T
M
A
K
F
L
Q
E
H
L
A
P
---
K
A
Q
E
-
I
------
D
R
S
N
E
F
-
K
N
L
R
E
F
W
---
K
Q
L
G
N
L
G
V
L
G
-
I
T
A
P
-
V
Q
Y
G
G
S
G
L
G
Y
L
---
E
H
V
L
V
M
E
E
I
S
R
A
S
G
A
--
V
G
L
S
--
Y
--
G
A
-
H
S
N
L
C
I
N
Q
L
V
R
N
G
N
E
A
Q
K
E
K
Y
L
P
K
L
I
S
--------
G
E
Y
I
G
A
L
A
M
S
E
P
N
A
G
S
D
V
V
--
S
--
M
K
L
K
A
E
K
K
--
G
N
H
Y
I
L
N
G
N
K
F
W
I
T
--
N
G
P
D
A
D
V
L
I
V
Y
A
K
T
D
L
A
AV---
P
A
--
S
R
G
I
T
---
A
F
I
V
E
K
G
M
P
G
F
S
T
----
S
K
K
L
--
D
KL
G
M--
R
---
G
S
N
T
C
E
L
I
F
E
D
C
K
I
P
A
A
N
-
I
L
G
H
E
N
K
G
-------
V
Y
V
L
M
S
G
L
D
L
E
R
L
V
L
A
G
G
P
L
G
L
M
Q
A
V
L
D
H
T
I
P
Y
L
H
V
R
E
A
F
G
Q
K
I
G
H
F
Q
L
M
Q
G
K
M
A
D
M
Y
T
R
L
M
A
C
R
Q
Y
V
Y
N
V
A
K
A
C
D
E
G
----------
H
------------------------
C
T
A
-
K
D
C
A
G
V
I
L
Y
S
A
E
C
A
T
Q
V
A
L
D
G
I
Q
C
F
G
G
N
G
Y
I
N
D
F
P
M
G
R
F
L
R
D
A
K
L
Y
E
I
G
A
G
T
S
E
V
R
R
L
V
I
G
R
A
F
N
A
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
66.39
16%
-67
- C2 -
4IRN
3
?
A:
[39-414]
--------------------------------------------------------
A
W
N
S
Q
Q
I
Q
----
F
R
K
K
V
I
Q
F
A
Q
Q
S
L
I
S
---
D
L
I
K
-
N
------
D
K
E
E
I
F
-
N
--
R
D
A
W
---
Q
K
C
S
E
F
G
V
H
G
-
W
P
I
P
-
A
R
Y
G
G
Q
E
L
D
I
L
---
T
T
A
Y
A
L
Q
G
L
G
Y
G
C
K
D
--
N
G
L
I
F
A
M
--
N
A
-
H
I
W
A
C
E
M
P
L
L
T
F
G
T
E
E
Q
K
E
K
Y
L
P
L
L
C
R
--------
G
G
W
I
A
S
H
A
A
T
E
P
Q
A
G
S
D
I
Y
--
S
--
L
K
T
T
A
Q
K
D
--
G
D
K
Y
I
L
N
G
Y
K
H
Y
V
T
--
N
G
T
I
A
D
L
F
I
I
F
A
T
I
D
P
S
-----
L
G
--
K
E
G
L
T
---
T
F
M
I
E
K
D
T
P
G
L
I
L
----
S
K
P
I
S
K
M
--
G
M--
R
---
T
A
E
V
P
E
L
R
L
E
N
C
E
V
S
A
A
N
-
R
L
G
E
E
G
T
G
-------
L
A
I
F
N
H
S
M
E
W
E
R
G
F
I
L
A
A
A
V
G
T
M
E
R
L
L
E
Q
S
I
R
Y
A
R
S
H
K
Q
F
G
Q
A
I
G
K
F
Q
L
V
A
N
K
L
V
E
M
K
L
R
L
E
N
A
K
A
Y
L
Y
K
V
A
W
M
K
E
N
K
----------
Q
------------------------
M
A
L
-
L
E
A
S
M
A
N
L
Y
I
S
E
A
W
V
Q
S
C
L
E
A
I
E
I
H
G
A
Y
G
Y
L
T
N
T
E
L
E
R
E
L
R
D
A
I
A
S
K
F
Y
S
G
T
S
E
I
Q
R
V
V
I
A
K
F
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
65.98
15%
-70
- C2 -
1SIQ
1
GCDH_HUMAN
A:
[11-386]
----------------------------------------------------
E
--
E
Q
L
T
T
D
E
I
L
----
I
R
D
T
F
R
T
Y
C
Q
E
R
L
M
P
---
R
I
L
L
-
A
------
N
R
N
E
V
F
-
H
--
R
E
I
I
---
S
E
M
G
E
L
G
V
L
G
-
P
T
I
K
--
G
Y
G
C
A
G
V
S
S
V
---
A
Y
G
L
L
A
R
E
L
E
R
V
D
S
G
--
Y
R
S
A
--
M
--
S
V
Q
S
-
S
L
V
M
H
P
I
Y
A
Y
G
S
E
E
Q
R
Q
K
Y
L
P
Q
L
A
K
--------
G
E
L
L
G
C
F
G
L
T
E
P
N
S
G
S
D
P
S
--
S
--
M
E
T
R
A
H
Y
N
SS
N
K
S
Y
T
L
N
G
T
K
T
W
I
T
--
N
S
P
M
A
D
L
F
V
V
W
A
R
C
E
D
-----------
G
C
I
R
---
G
F
L
L
E
K
G
M
R
G
L
S
A
----
P
R
I
Q
GK
F
--
S
L--
R
---
A
S
A
T
G
M
I
I
M
D
G
V
E
V
P
E
E
N
-
V
L
P
G
A
S
-
S
-------
L
G
G
P
F
G
C
L
N
N
A
R
Y
G
I
A
W
G
V
L
G
A
S
E
F
C
L
H
T
A
R
Q
Y
A
L
D
R
M
Q
F
G
V
P
L
A
R
N
Q
L
I
Q
K
K
L
A
D
M
L
T
E
I
T
L
G
L
H
A
C
L
Q
L
G
R
L
K
D
Q
D
----------------------------------
K
A
A
P
-
E
M
V
S
L
L
K
R
N
N
C
G
K
A
L
D
I
A
R
Q
A
R
D
M
L
G
G
N
G
I
S
D
E
Y
H
V
I
R
H
A
M
N
L
E
A
V
N
T
Y
E
G
T
H
D
I
H
A
L
I
L
G
R
A
I
T
G
I
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
65.50
16%
-75
- C2 -
4W9U
2
?
A:
[16-391]
----------------------------------------------------
E
--
E
Q
L
T
E
D
E
R
M
----
I
R
D
S
A
K
A
F
A
S
D
V
L
L
P
---
R
V
E
----------------
D
--
P
E
L
F
---
H
L
M
G
Q
A
G
L
L
G
-
V
T
L
P
-
E
D
Y
G
A
A
N
A
S
Y
V
---
A
Y
G
L
V
A
R
E
V
E
R
I
D
S
G
--
Y
R
S
M
--
M
--
S
V
-
Q
S
S
L
V
M
Y
P
I
Y
A
Y
G
S
D
E
Q
R
K
K
Y
L
P
G
L
V
S
--------
G
E
L
I
G
C
F
G
L
T
E
P
------------
M
K
T
R
A
E
K
I
--
D
G
G
Y
R
L
S
G
S
K
M
W
I
S
--
N
S
P
I
A
D
V
F
V
V
W
A
K
S
A
A
-------
H
--
D
N
A
I
R
---
G
F
I
L
E
K
G
M
K
G
L
S
A
----
P
K
I
--------------
A
S
I
T
G
E
I
V
M
D
G
V
E
V
S
E
D
A
-
I
L
P
N
V
-
S
G
-------
L
K
G
P
F
G
C
L
N
R
A
R
Y
G
I
S
W
G
V
L
G
A
A
E
D
C
W
F
R
A
R
Q
Y
G
L
D
R
K
Q
F
N
K
P
L
A
G
T
Q
L
Y
Q
K
K
L
A
D
M
Q
T
E
I
A
L
G
I
Q
A
S
L
R
V
G
R
L
F
D
E
G
----------
K
M
------------------------
A
P
-
E
M
I
S
I
V
K
R
N
N
C
G
K
A
L
D
I
A
R
Q
A
R
D
M
H
G
-------
Y
H
V
M
R
H
A
Q
N
L
E
T
V
N
T
Y
E
G
T
H
D
V
H
A
L
I
L
G
R
A
Q
T
G
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------