@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0243: (2016-04-20 )
MAPAAKNTSQTRRRVAVLGGNRIPFARSDGAYADASNQDMFTAALSGLVDRFGLAGERLDMVVGGAVLKHSRDFNLMRECVLGSELSPYTPAFDLQQACGTGLQAAIAAADGIAAGRYEVAAAGGVDTTSDPPIGLGDDLRRTLLKLRRSRSNVQRLKLVGTLPASLGVEIPANSEPRTGLSMGEHAAVTAKQMGIKRVDQDELAAASHRNMADAYDRGFFDDLVSPFLGLYRDDNLRPNSSVEKLATLRPVFGVKAGDATMTAGNSTPLTDGASVALLASEQWAEAHSLAPLAYLVDAETAAVDYVNGNDGLLMAPTYAVPRLLARNGLSLQDFDFYEIHEAFASVVLAHLAAWESEEYCKRRLGLDAALGSIDRSKLNVNGSSLAAGHPFAATGGRILAQTAKQLAEKKAAKKGGGPLRGLISICAAGGQGVAAILEA
Atome Classification :
(20 SA)
.........10........20.......-.-30........40........50.-..-.....60........-70-.-.-......80........90........100.......110.......120.......130.....-..140---------........150.......160.......170-.......180.......190.......200.......210.......220.--------.....--------.--------------230-------...---------......240.......250.......260.......270.......280.......290.......300..-.-....310...--....320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420........430.......440
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAPAAK
N
T
S
Q
T
R
R
R
V
A
V
LGGNRIPFARS-D-GAYADASN
Q
D
M
F
T
A
A
L
S
G
L
V
D
R
F-GL-AG
E
R
L
D
M
V
VG
G
A
V
LK-HS-
R
-
D
-
F
N
L
M
R
E
C
VLGSELSPYTP
A
F
D
L
Q
Q
A
C
G
T
G
L
Q
A
A
I
A
AADGIAAG
R
Y
E
V
A
AAGGVDTTSDPPIG
L
G
-
D
D
L
R
----------
R
T
L
L
K
L
R
R
SRS
N
V
Q
R
L
K
L
V
G
TL
P
A
S
L
G
V
EIP-ANSEPRTGLSMGE
H
A
A
V
T
A
K
Q
MGIKRV
D
Q
D
E
L
A
A
A
SHR
N
M
A
D
A
Y
DR
G
F
F
D
D
--------
L
V
S
P
F
--------
L
--------------
G
---------
L
YR---------DDNLRPN
S
S
V
E
K
L
A
TLRP
V
F
G
VKAGD
A
T
MTAGNSTPLTDG
A
S
V
A
L
L
A
S
E
Q
W
A
E
AHSLA
P
L
A
Y
L
VDAE
T
A
A
V
-
D
-
Y
VNGND
G
L
L
M--A
P
T
Y
A
V
P
R
L
L
A
RNGLSLQD
F
D
F
Y
E
I
H
E
A
F
A
S
V
V
L
A
H
L
AAWE
S
E
E
Y
C
K
R
RLG
L
D
A
A
LGSIDR
S
K
LNVNGSSLAAGHPFAATG
G
R
I
L
A
Q
T
A
K
Q
L
A
E
K
K
A
AKKGGG
P
L
R
-
G
L
I
S
I
CAAGG
Q
G
V
A
A
I
LEA
25
HHSearch
94.55
32%
-66
- C1 -
4C2J
8
THIM_HUMAN
A:
[20-415]
-------
H
M
A
L
L
R
G
V
F
V
V
A
A
K
R
T
P
F
G
A
Y
-
G
-
G
L
L
K
D
F
T
A
T
D
L
S
E
F
A
A
K
A
A
L
S
A
G
-
K
V
-
S
P
E
T
V
D
S
V
I
M
G
N
V
L
Q
-
S
S
S
D
-
A
-
I
Y
L
A
R
H
V
G
L
R
V
G
I
P
K
E
T
P
A
L
T
I
N
R
L
C
G
S
G
F
Q
S
I
V
N
G
C
Q
E
I
C
V
K
E
A
E
V
V
L
C
G
G
T
E
S
M
S
Q
A
P
Y
C
V
R
-
N
V
R
F
-------------
G
-----
T
K
L
G
S
D
I
K
L
----
E
D
S
L
---
W
V
-
S
L
T
D
Q
H
V
Q
L
P
M
A
M
T
A
E
N
L
A
V
K
H
K
I
S
R
E
E
C
D
K
Y
A
L
Q
S
Q
Q
R
W
K
A
A
N
D
A
G
Y
F
N
D
--------
E
M
A
P
I
--------
E
--------------
V
KKQT-----
M
Q
V
---------
D
E
H
A
R
P
Q
T
T
L
E
Q
L
Q
K
L
P
P
V
F
K
K
---
D
G
T
V
T
A
G
N
A
S
G
V
A
D
G
A
G
A
V
I
I
A
S
E
D
A
V
K
K
H
N
F
T
P
L
A
R
I
V
G
Y
F
V
S
-
G
-
C
-
D
P
---
S
I
M
G
I
--
G
P
V
P
A
I
S
G
A
L
K
K
A
G
L
S
L
K
D
M
D
L
V
E
V
N
E
A
F
A
P
Q
Y
L
A
V
E
---
R
S
-------
L
D
L
-------
D
I
S
K
T
N
V
N
G
G
A
I
A
L
G
H
P
L
G
G
S
G
S
R
I
T
A
H
L
V
H
E
L
R
R
R
-----
G
--
G
K
Y
-
A
V
G
S
A
C
I
G
G
G
Q
G
I
A
V
I
I
Q
S
2
PsiBlast_PDB
94.03
30%
-71
- C1 -
3SS6
6
?
A:
[1-393]
--------
S
N
A
M
H
N
V
V
I
T
A
A
V
R
S
P
I
G
T
F
-
G
-
G
A
L
K
N
V
T
P
V
E
L
A
V
P
V
L
Q
E
A
V
K
R
G
-
G
V
-
E
P
H
E
V
D
E
V
I
L
G
H
C
I
Q
-
R
T
-
D
-
E
-
A
N
T
A
R
T
A
A
L
A
A
G
F
P
D
T
V
T
G
Y
T
I
Q
R
Q
C
S
S
G
M
Q
A
I
M
S
A
A
M
Q
I
Q
L
G
V
S
E
V
V
V
A
G
G
V
E
A
M
S
S
S
P
Y
A
--------------------
L
K
Q
H
R
W
G
Q
R
L
Q
H
G
E
I
R
D
T
V
W
E
V
L
--------
E
D
P
I
H
H
I
M
M
G
E
T
A
E
N
L
V
E
Q
Y
E
I
T
R
E
E
Q
D
E
V
A
L
R
S
H
T
L
A
L
K
A
I
E
S
G
Y
F
D
D
--------
Q
I
V
P
I
T
IKER
R
K
E
V
--------------
V
---------
F
S
K
---------
D
E
H
P
R
A
D
I
T
A
E
K
L
A
G
L
K
P
A
F
---
R
K
D
G
S
V
T
A
G
N
A
S
G
L
N
D
G
S
A
V
L
V
L
M
S
E
E
K
A
K
E
K
G
L
Q
P
L
A
R
I
V
G
Y
S
V
A
G
V
-
D
P
K
I
M
G
-----
I
--
G
P
A
P
A
I
R
K
G
L
E
K
V
D
W
S
L
E
D
A
D
L
L
E
I
N
E
A
F
A
A
Q
Y
L
A
----------
V
E
K
E
L
D
L
-------
D
R
E
K
V
N
V
N
G
S
G
V
G
L
G
H
P
I
G
C
T
G
A
R
I
T
V
S
L
I
H
E
L
K
R
R
-------
G
L
E
K
-
G
I
A
S
L
C
V
G
G
G
I
G
V
A
L
F
I
E
A
27
HHSearch
93.82
34%
-68
- C1 -
3SS6
6
?
A:
[2-393]
---------
N
A
M
H
N
V
V
I
T
A
A
V
R
S
P
I
G
T
F
-
G
-
G
A
L
K
N
V
T
P
V
E
L
A
V
P
V
L
Q
E
A
V
K
R
G
-
G
V
-
E
P
H
E
V
D
E
V
I
L
G
H
C
I
Q
-
R
T
-
D
-
E
-
A
N
T
A
R
T
A
A
L
A
A
G
F
P
D
T
V
T
G
Y
T
I
Q
R
Q
C
S
S
G
M
Q
A
I
M
S
A
A
M
Q
I
Q
L
G
V
S
E
V
V
V
A
G
G
V
E
A
M
S
S
S
P
Y
A
L
K
-
Q
-
H
R
----------
W
G
--------
Q
R
L
Q
H
G
E
--
I
R
D
T
V
-
W
--
E
V
L
--
E
-
D
P
I
H
H
I
M
M
G
E
T
A
E
N
L
V
E
Q
Y
E
I
T
R
E
E
Q
D
E
V
A
L
R
S
H
T
L
A
L
K
A
I
E
S
G
Y
F
D
D
--------
Q
I
V
P
I
--------
T
--------------
I
KER
R
K
E
V
V
-
F
S
K
---------
D
E
H
P
R
A
D
I
T
A
E
K
L
A
G
L
K
P
A
F
R
---
K
D
G
S
V
T
A
G
N
A
S
G
L
N
D
G
S
A
V
L
V
L
M
S
E
E
K
A
K
E
K
G
L
Q
P
L
A
R
I
V
G
Y
S
V
A
G
V
-
D
-
P
----
K
I
M
G
I
--
G
P
A
P
A
I
R
K
G
L
E
K
V
D
W
S
L
E
D
A
D
L
L
E
I
N
E
A
F
A
A
Q
Y
L
A
V
E
---
K
E
L
-------
D
L
-------
D
R
E
K
V
N
V
N
G
S
G
V
G
L
G
H
P
I
G
C
T
G
A
R
I
T
V
S
L
I
H
E
L
K
R
R
-----
G
--
L
E
K
-
G
I
A
S
L
C
V
G
G
G
I
G
V
A
L
F
I
E
A
3
PsiBlast_PDB
93.46
30%
-69
- C1 -
4C2K
10
THIM_HUMAN
A:
[25-415]
------------
R
G
V
F
V
V
A
A
K
R
T
P
F
G
A
Y
-
G
-
G
L
L
K
D
F
T
A
T
D
L
S
E
F
A
A
K
A
A
L
S
A
G
-
K
V
-
S
P
E
T
V
D
S
V
I
M
G
N
V
L
Q
-
S
S
-
S
-
D
A
I
Y
L
A
R
H
V
G
L
R
V
G
I
P
K
E
T
P
A
L
T
I
N
R
L
C
G
S
G
F
Q
S
I
V
N
G
C
Q
E
I
C
V
K
E
A
E
V
V
L
C
G
G
T
E
S
M
S
Q
A
P
Y
-------------------
C
V
R
N
V
R
F
G
T
K
L
G
S
D
I
K
L
E
D
S
L
W
V
S
L
--------
T
D
Q
H
V
Q
L
P
M
A
M
T
A
E
N
L
A
V
K
H
K
I
S
R
E
E
C
D
K
Y
A
L
Q
S
Q
Q
R
W
K
A
A
N
D
A
G
Y
F
N
D
--------
E
M
A
P
I
E
V
K
T
KK
G
K
Q
--------------
T
---------
M
Q
V
---------
D
E
H
A
R
P
Q
T
T
L
E
Q
L
Q
K
L
P
P
V
F
---
K
K
D
G
T
V
T
A
G
N
A
S
G
V
A
D
G
A
G
A
V
I
I
A
S
E
D
A
V
K
K
H
N
F
T
P
L
A
R
I
V
G
Y
--------
F
V
S
G
C
D
P
S
I
M
GI
G
P
V
P
A
I
S
G
A
L
K
K
A
G
L
S
L
K
D
M
D
L
V
E
V
N
E
A
F
A
P
Q
Y
L
A
----------
V
E
R
S
L
D
L
D
I
-------
S
K
T
N
V
N
G
G
A
I
A
L
G
H
P
L
G
G
S
G
S
R
I
T
A
H
L
V
H
E
L
-----
R
R
R
G
G
K
Y
A
V
-
G
--
S
A
C
I
G
G
G
Q
G
I
A
V
I
I
Q
S
5
PsiBlast_PDB
93.39
29%
-68
- C1 -
4C2J
8
THIM_HUMAN
A:
[25-415]
------------
R
G
V
F
V
V
A
A
K
R
T
P
F
G
A
Y
-
G
-
G
L
L
K
D
F
T
A
T
D
L
S
E
F
A
A
K
A
A
L
S
A
G
-
K
V
-
S
P
E
T
V
D
S
V
I
M
G
N
V
L
Q
-
S
S
-
S
-
D
A
I
Y
L
A
R
H
V
G
L
R
V
G
I
P
K
E
T
P
A
L
T
I
N
R
L
C
G
S
G
F
Q
S
I
V
N
G
C
Q
E
I
C
V
K
E
A
E
V
V
L
C
G
G
T
E
S
M
S
Q
A
P
Y
-------------------
C
V
R
N
V
R
F
G
T
K
L
G
S
D
I
K
L
E
D
S
L
W
V
S
L
--------
T
D
Q
H
V
Q
L
P
M
A
M
T
A
E
N
L
A
V
K
H
K
I
S
R
E
E
C
D
K
Y
A
L
Q
S
Q
Q
R
W
K
A
A
N
D
A
G
Y
F
N
D
--------
E
M
A
P
I
E
VKK----
Q
--------------
T
---------
M
Q
V
---------
D
E
H
A
R
P
Q
T
T
L
E
Q
L
Q
K
L
P
P
V
F
---
K
K
D
G
T
V
T
A
G
N
A
S
G
V
A
D
G
A
G
A
V
I
I
A
S
E
D
A
V
K
K
H
N
F
T
P
L
A
R
I
V
G
Y
--------
F
V
S
G
C
D
P
S
I
M
G
I
G
P
V
P
A
I
S
G
A
L
K
K
A
G
L
S
L
K
D
M
D
L
V
E
V
N
E
A
F
A
P
Q
Y
L
A
----------
V
E
R
S
L
D
L
D
I
-------
S
K
T
N
V
N
G
G
A
I
A
L
G
H
P
L
G
G
S
G
S
R
I
T
A
H
L
V
H
E
L
-----
R
R
R
G
G
K
Y
A
V
-
G
--
S
A
C
I
G
G
G
Q
G
I
A
V
I
I
Q
S
4
PsiBlast_PDB
90.67
30%
-68
- C1 -
4W61
-
BKTB_CUPNH
A:
[1-392]
----------
M
T
R
E
V
V
V
V
S
G
V
R
T
A
I
G
T
F
-
G
-
G
S
L
K
D
V
A
P
A
E
L
G
A
L
V
V
R
E
A
L
A
R
A
-
Q
V
-
S
G
D
D
V
G
H
V
V
F
G
N
V
I
Q
T
E
P
-
R
-
D
-
M
Y
L
G
R
V
A
A
V
N
G
G
V
T
I
N
A
P
A
L
T
V
N
R
L
C
G
S
G
L
Q
A
I
V
S
A
A
Q
T
I
L
L
G
D
T
D
V
A
I
G
G
G
A
E
S
M
S
R
A
P
Y
--------------------
L
A
P
A
A
R
W
G
A
R
M
G
D
A
G
L
V
D
M
M
L
G
A
L
--------
H
D
P
F
H
R
I
H
M
G
V
T
A
E
N
V
A
K
E
Y
D
I
S
R
A
Q
Q
D
E
A
A
L
E
S
H
R
R
A
S
A
A
I
K
A
G
Y
F
K
D
--------
Q
I
V
P
V
--------
V
--------------
S
---------
K
G
R
K
G
D
V
T
F
D
T
-
D
E
H
V
R
H
D
A
T
I
D
D
M
T
K
L
R
P
V
F
-
V
K
E
-
N
G
T
V
T
A
G
N
A
S
G
L
N
D
A
A
A
A
V
V
M
M
E
R
A
E
A
E
R
R
G
L
K
P
L
A
R
L
V
S
Y
G
H
A
G
V
-
D
-----
P
K
A
M
G
I
--
G
P
V
P
A
T
K
I
A
L
E
R
A
G
L
Q
V
S
D
L
D
V
I
E
A
N
E
A
F
A
A
Q
A
C
A
----------
V
T
K
A
L
G
L
D
P
A
-------
K
V
N
P
N
G
S
G
I
S
L
G
H
P
I
G
A
T
G
A
L
I
T
V
K
A
L
H
E
L
N
R
V
Q
G
R
Y
--------
A
L
V
T
M
C
I
G
G
G
Q
G
I
A
A
I
F
E
-
37
HHSearch
90.58
33%
-66
- C1 -
1ULQ
-
?
A:
[3-399]
-------------
E
A
W
I
V
E
A
V
R
T
P
I
G
K
H
-
G
-
G
A
L
A
S
V
R
P
D
D
L
L
A
H
A
L
S
V
L
V
D
R
S
-
G
V
-
P
K
E
E
V
E
D
V
Y
A
G
C
A
N
Q
-
A
G
-
E
D
N
-
R
N
V
A
R
M
A
L
L
L
A
G
F
P
V
E
V
A
G
C
T
V
N
R
L
C
G
S
G
L
E
A
V
A
Q
A
A
R
A
I
W
A
G
E
G
K
V
Y
I
G
S
G
V
E
S
M
S
R
A
P
Y
A
V
P
-
K
P
E
R
----------
G
F
P
T
-
G
-
N
L
V
M
Y
D
T
T
L
G
W
--
R
----
F
--
V
N
P
-
K
M
Q
A
L
Y
G
T
E
S
M
G
E
T
A
E
N
L
A
E
M
Y
G
I
R
R
E
E
Q
D
R
F
A
L
L
S
H
Q
K
A
V
R
A
W
E
E
G
R
F
Q
D
--------
E
V
V
P
V
--------
P
--------------
V
K
RGK
E
E
I
L
-
V
E
Q
---------
D
E
G
P
R
R
D
T
S
L
E
K
L
A
A
L
R
P
V
F
R
E
---
G
G
T
V
T
A
G
N
S
S
P
L
N
D
G
A
A
A
V
L
L
V
S
D
D
Y
A
K
A
H
G
L
R
P
L
A
R
V
R
A
I
A
V
A
-
G
-
V
-
P
P
---
R
I
M
G
I
--
G
P
V
P
A
T
R
K
A
L
E
R
A
G
L
S
F
S
D
L
G
L
I
E
L
N
E
A
F
A
A
Q
A
L
A
V
L
---
R
E
W
S
L
S
------------
M
E
D
Q
R
L
N
P
N
G
G
A
I
A
L
G
H
P
L
G
A
S
G
A
R
I
L
T
T
L
V
H
E
M
R
R
R
-----
K
--
V
Q
F
-
G
L
A
T
M
C
I
G
V
G
Q
G
I
A
V
V
V
E
G
17
PsiBlast_PDB
89.81
30%
-70
- C1 -
4O99
1
THIL_CUPNH
A:
[3-390]
--------------
V
V
I
V
S
A
A
R
T
A
V
G
K
F
-
G
-
G
S
L
A
K
I
P
A
P
E
L
G
A
V
V
I
K
A
A
L
E
R
A
-
G
V
-
K
P
E
Q
V
S
E
V
I
M
G
Q
V
L
T
-
A
G
-
S
-
G
-
Q
N
P
A
R
Q
A
A
I
K
A
G
L
P
A
M
V
P
A
M
T
I
N
K
V
C
G
S
G
L
K
A
V
M
L
A
A
N
A
I
M
A
G
D
A
E
I
V
V
A
G
G
Q
E
N
M
S
A
A
P
--------------------
H
V
L
P
G
S
R
D
G
F
R
M
G
D
A
K
L
V
D
T
M
I
V
D
-
G
L
W
D
V
-
Y
N
Q
-----
Y
H
M
G
I
T
A
E
N
V
A
K
E
Y
G
I
T
R
E
A
Q
D
E
F
A
V
G
S
Q
N
K
A
E
A
A
Q
K
A
G
K
F
D
E
--------
E
I
V
P
V
--------
L
--------------
I
---------
P
Q
R
K
G
D
P
V
A
F
K
T
D
E
F
V
R
Q
G
A
T
L
D
S
M
S
G
L
K
P
A
F
D
-
K
A
G
--
T
V
T
A
A
N
A
S
G
L
N
D
G
A
A
A
V
V
V
M
S
A
A
K
A
K
E
L
G
L
T
P
L
A
T
I
K
S
Y
A
N
A
G
V
-
D
P
K
V
M
G
-----
M
--
G
P
V
P
A
S
K
R
A
L
S
R
A
E
W
T
P
Q
D
L
D
L
M
E
I
N
E
A
F
A
A
Q
A
L
A
----------
V
H
Q
Q
M
G
W
D
T
-------
S
K
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
C
R
I
L
V
T
L
L
H
E
M
K
R
R
D
A
K
K
--------
G
L
A
S
L
C
I
G
G
G
M
G
V
A
L
A
V
E
-
6
PsiBlast_PDB
89.23
30%
-68
- C1 -
4NZS
-
BKTB_CUPNH
A:
[3-392]
------------
R
E
V
V
V
V
S
G
V
R
T
A
I
G
T
F
-
G
-
G
S
L
K
D
V
A
P
A
E
L
G
A
L
V
V
R
E
A
L
A
R
A
-
Q
V
-
S
G
D
D
V
G
H
V
V
F
G
N
V
I
Q
T
E
P
-
R
-
D
-
M
Y
L
G
R
V
A
A
V
N
G
G
V
T
I
N
A
P
A
L
T
V
N
R
L
C
G
S
G
L
Q
A
I
V
S
A
A
Q
T
I
L
L
G
D
T
D
V
A
I
G
G
G
A
E
S
M
S
R
A
P
Y
--------------------
L
A
P
A
A
R
W
G
A
R
M
G
D
A
G
L
V
D
M
M
L
G
A
L
--------
H
D
P
F
H
R
I
H
M
G
V
T
A
E
N
V
A
K
E
Y
D
I
S
R
A
Q
Q
D
E
A
A
L
E
S
H
R
R
A
S
A
A
I
K
A
G
Y
F
K
D
--------
Q
I
V
P
V
--------
V
--------------
S
---------
K
G
R
K
G
D
V
T
F
D
T
-
D
E
H
V
R
H
D
A
T
I
D
D
M
T
K
L
R
P
V
F
-
V
K
E
-
N
G
T
V
T
A
G
N
A
S
G
L
N
D
A
A
A
A
V
V
M
M
E
R
A
E
A
E
R
R
G
L
K
P
L
A
R
L
V
S
Y
G
H
A
G
V
-
D
-----
P
K
A
M
G
I
--
G
P
V
P
A
T
K
I
A
L
E
R
A
G
L
Q
V
S
D
L
D
V
I
E
A
N
E
A
F
A
A
Q
A
C
A
----------
V
T
K
A
L
G
L
D
P
A
-------
K
V
N
P
N
G
S
G
I
S
L
G
H
P
I
G
A
T
G
A
L
I
T
V
K
A
L
H
E
L
N
R
V
Q
G
R
Y
--------
A
L
V
T
M
C
I
G
G
G
Q
G
I
A
A
I
F
E
-
30
HHSearch
89.22
31%
-61
- C1 -
4W61
-
BKTB_CUPNH
A:
[1-393]
----------
M
T
R
E
V
V
V
V
S
G
V
R
T
A
I
G
T
F
-
G
-
G
S
L
K
D
V
A
P
A
E
L
G
A
L
V
V
R
E
A
L
A
R
A
-
Q
V
-
S
G
D
D
V
G
H
V
V
F
G
N
V
I
Q
-
T
E
P
R
-
D
-
M
Y
L
G
R
V
A
A
V
N
G
G
V
T
I
N
A
P
A
L
T
V
N
R
L
C
G
S
G
L
Q
A
I
V
S
A
A
Q
T
I
L
L
G
D
T
D
V
A
I
G
G
G
A
E
S
M
S
R
A
P
Y
L
A
P
-
A
-
A
R
----------
W
G
------
A
R
M
G
D
A
G
L
---------
V
D
M
M
L
G
-
A
L
H
D
P
F
H
R
I
H
M
G
V
T
A
E
N
V
A
K
E
Y
D
I
S
R
A
Q
Q
D
E
A
A
L
E
S
H
R
R
A
S
A
A
I
K
A
G
Y
F
K
D
--------
Q
I
V
P
V
--------
V
--------------
S
K
G
RK
G
D
V
T
-
F
D
T
---------
D
E
H
V
R
H
D
A
T
I
D
D
M
T
K
L
R
P
V
F
V
K
--
E
N
G
T
V
T
A
G
N
A
S
G
L
N
D
A
A
A
A
V
V
M
M
E
R
A
E
A
E
R
R
G
L
K
P
L
A
R
L
V
S
Y
G
H
A
-
G
-
V
-
D
---
P
K
A
M
G
I
--
G
P
V
P
A
T
K
I
A
L
E
R
A
G
L
Q
V
S
D
L
D
V
I
E
A
N
E
A
F
A
A
Q
A
C
A
V
T
---
K
A
L
G
L
D
--------------
P
A
K
V
N
P
N
G
S
G
I
S
L
G
H
P
I
G
A
T
G
A
L
I
T
V
K
A
L
H
E
L
N
R
V
-----
Q
--
G
R
Y
-
A
L
V
T
M
C
I
G
G
G
Q
G
I
A
A
I
F
E
R
18
PsiBlast_PDB
88.76
27%
-68
- C1 -
1WL4
7
THIC_HUMAN
A:
[8-395]
--------------
V
V
I
V
S
A
A
R
T
I
I
G
S
F
-
N
-
G
A
L
A
A
V
P
V
Q
D
L
G
S
T
V
I
K
E
V
L
K
R
A
-
T
V
-
A
P
E
D
V
S
E
V
I
F
G
H
V
L
A
-
A
G
-
C
-
G
-
Q
N
P
V
R
Q
A
S
V
G
A
G
I
P
Y
S
V
P
A
W
S
C
Q
M
I
C
G
S
G
L
K
A
V
C
L
A
V
Q
S
I
G
I
G
D
S
S
I
V
V
A
G
G
M
E
N
M
S
K
A
P
-----------------------
H
L
A
Y
L
R
T
G
V
K
----
I
G
E
M
P
L
T
D
S
I
L
C
D
-
G
L
T
D
A
F
H
N
C
H
M
G
I
T
A
E
N
V
A
K
K
W
Q
V
S
R
E
D
Q
D
K
V
A
V
L
S
Q
N
R
T
E
N
A
Q
K
A
G
H
F
D
K
--------
E
I
V
P
V
--------
L
V
S
TR
K
---------
G
---------
L
I
E
V
K
T------
D
E
F
P
R
H
G
S
N
I
E
A
M
S
K
L
K
P
Y
F
-
L
T
D
G
T
G
T
V
T
P
A
N
A
S
G
I
N
D
G
A
A
A
V
V
L
M
K
K
S
E
A
D
K
R
G
L
T
P
L
A
R
I
V
S
W
S
Q
V
G
V
-
E
P
S
I
M
G
-----
I
--
G
P
I
P
A
I
K
Q
A
V
T
K
A
G
W
S
L
E
D
V
D
I
F
E
I
N
E
A
F
A
A
V
S
A
A
I
V
----------
K
E
L
G
L
N
P
-------
E
K
V
N
I
E
G
G
A
I
A
L
G
H
P
L
G
A
S
G
C
R
I
L
V
T
L
L
H
T
L
E
R
M
-------
G
R
S
R
-
G
V
A
A
L
C
I
G
G
G
M
G
I
A
M
C
V
Q
-
28
HHSearch
88.70
31%
-67
- C1 -
3GOA
2
FADA_SALTY
A:
[1-386]
-----------
M
E
Q
V
V
I
V
D
A
I
R
T
P
M
G
R
S
-
K
G
G
A
F
R
N
V
R
A
E
D
L
S
A
H
L
M
R
S
L
L
A
R
N
P
S
L
-
T
A
A
T
L
D
D
I
Y
W
G
C
V
Q
Q
-
T
L
E
Q
-
G
-
F
N
I
A
R
N
A
A
L
L
A
E
I
P
H
S
V
P
A
V
T
V
N
R
L
C
G
S
S
M
Q
A
L
H
D
A
A
R
M
I
M
T
G
D
A
Q
V
C
L
V
G
G
V
E
H
M
G
H
V
P
M
S
H
G
-
V
D
-----------------------
F
H
---------
P
G
L
S
--------------
G
M
M
G
L
T
A
E
M
L
S
R
L
H
G
I
S
R
E
M
Q
D
Q
F
A
A
R
S
H
A
R
A
W
A
A
T
Q
S
G
A
F
K
T
--------
E
I
I
P
T
--------
G
G
H
D
ADG
V
L
K
-----
Q
---------
F
N
Y
---------
D
E
V
I
R
P
E
T
T
V
E
A
L
S
T
L
R
P
A
F
D
P
--
V
S
G
T
V
T
A
G
T
S
S
A
L
S
D
G
A
A
A
M
L
V
M
S
E
S
R
A
R
E
L
G
L
K
P
R
A
R
I
R
S
M
A
V
V
G
C
-
D
-
P
----
S
I
M
G
Y
--
G
P
V
P
A
S
K
L
A
L
K
K
A
G
L
S
A
S
D
I
D
V
F
E
M
N
E
A
F
A
A
Q
I
L
P
C
I
---
K
D
L
G
L
M
E
Q
I
-----------
D
E
K
I
N
L
N
G
G
A
I
A
L
G
H
P
L
G
C
S
G
A
R
I
S
T
T
L
I
-
N
L
M
E
R
-----
K
-
D
A
Q
F
-
G
L
A
T
M
C
I
G
L
G
Q
G
I
A
T
V
F
E
R
1
PsiBlast_PDB
88.67
32%
-67
- C1 -
1ULQ
-
?
A:
[11-398]
---------------------
R
T
P
I
G
K
H
-
G
-
G
A
L
A
S
V
R
P
D
D
L
L
A
H
A
L
S
V
L
V
D
R
S
-
G
V
-
P
K
E
E
V
E
D
V
Y
A
G
C
A
N
Q
-
A
G
-
E
-
D
N
R
N
V
A
R
M
A
L
L
L
A
G
F
P
V
E
V
A
G
C
T
V
N
R
L
C
G
S
G
L
E
A
V
A
Q
A
A
R
A
I
W
A
G
E
G
K
V
Y
I
G
S
G
V
E
S
M
S
R
A
P
Y
A
V
P
-
K
P
E
R
GF
P
T
G
N
L
V
M
Y
D
T
T
L
G
W
R
F
V
N
P
K
M
Q
A
L
---------
Y
G
T
E
------------
S
M
G
E
T
A
E
N
L
A
E
M
Y
G
I
R
R
E
E
Q
D
R
F
A
L
L
S
H
Q
K
A
V
R
A
W
E
E
G
R
F
Q
D
--------
E
V
V
P
V
P
V
K
RGK
E
E
I
--------------
L
---------
V
E
Q
---------
D
E
G
P
R
R
D
T
S
L
E
K
L
A
A
L
R
P
V
F
--
R
E
G
-
G
T
V
T
A
G
N
S
S
P
L
N
D
G
A
A
A
V
L
L
V
S
D
D
Y
A
K
A
H
G
L
R
P
L
A
R
V
R
A
I
A
V
A
G
V
P
P
-
R
I
M
G
-----
I
--
G
P
V
P
A
T
R
K
A
L
E
R
A
G
L
S
F
S
D
L
G
L
I
E
L
N
E
A
F
A
A
Q
A
L
A
V
L
R
E
W
S
L
---------------
S
M
E
D
Q
R
L
N
P
N
G
G
A
I
A
L
G
H
P
L
G
A
S
G
A
R
I
L
T
T
L
V
H
E
M
R
R
R
K
V
Q
F
--------
G
L
A
T
M
C
I
G
V
G
Q
G
I
A
V
V
V
E
-
19
PsiBlast_PDB
88.20
27%
-68
- C1 -
1WL5
5
THIC_HUMAN
A:
[8-395]
--------------
V
V
I
V
S
A
A
R
T
I
I
G
S
F
-
N
-
G
A
L
A
A
V
P
V
Q
D
L
G
S
T
V
I
K
E
V
L
K
R
A
-
T
V
-
A
P
E
D
V
S
E
V
I
F
G
H
V
L
A
-
A
G
-
C
-
G
-
Q
N
P
V
R
Q
A
S
V
G
A
G
I
P
Y
S
V
P
A
W
S
C
Q
M
I
C
G
S
G
L
K
A
V
C
L
A
V
Q
S
I
G
I
G
D
S
S
I
V
V
A
G
G
M
E
N
M
S
K
A
P
-----------------------
H
L
A
Y
L
R
T
G
V
K
----
I
G
E
M
P
L
T
D
S
I
L
C
D
-
G
L
T
D
A
F
H
N
C
H
M
G
I
T
A
E
N
V
A
K
K
W
Q
V
S
R
E
D
Q
D
K
V
A
V
L
S
Q
N
R
T
E
N
A
Q
K
A
G
H
F
D
K
--------
E
I
V
P
V
--------
L
V
S
TR
K
---------
G
---------
L
I
E
V
K
T------
D
E
F
P
R
H
G
S
N
I
E
A
M
S
K
L
K
P
Y
F
-
L
T
D
G
T
G
T
V
T
P
A
N
A
S
G
I
N
D
G
A
A
A
V
V
L
M
K
K
S
E
A
D
K
R
G
L
T
P
L
A
R
I
V
S
W
S
Q
V
G
V
-
E
P
S
I
M
G
-----
I
--
G
P
I
P
A
I
K
Q
A
V
T
K
A
G
W
S
L
E
D
V
D
I
F
E
I
N
E
A
F
A
A
V
S
A
A
I
V
----------
K
E
L
G
L
N
P
-------
E
K
V
N
I
E
G
G
A
I
A
L
G
H
P
L
G
A
S
G
C
R
I
L
V
T
L
L
H
T
L
E
R
M
-------
G
R
S
R
-
G
V
A
A
L
C
I
G
G
G
M
G
I
A
M
C
V
Q
-
31
HHSearch
88.13
28%
-59
- C1 -
1WL4
7
THIC_HUMAN
A:
[4-396]
----------
G
S
D
P
V
V
I
V
S
A
A
R
T
I
I
G
S
F
-
N
-
G
A
L
A
A
V
P
V
Q
D
L
G
S
T
V
I
K
E
V
L
K
R
A
-
T
V
-
A
P
E
D
V
S
E
V
I
F
G
H
V
L
A
-
A
G
-
C
-
G
-
Q
N
P
V
R
Q
A
S
V
G
A
G
I
P
Y
S
V
P
A
W
S
C
Q
M
I
C
G
S
G
L
K
A
V
C
L
A
V
Q
S
I
G
I
G
D
S
S
I
V
V
A
G
G
M
E
N
M
S
K
A
P
H
L
A
Y
-
L
R
------------
T
G
V
-------
K
I
G
E
M
-
P
L
----
T
D
S
---
I
L
C
D
G
L
T
D
A
F
H
N
C
H
M
G
I
T
A
E
N
V
A
K
K
W
Q
V
S
R
E
D
Q
D
K
V
A
V
L
S
Q
N
R
T
E
N
A
Q
K
A
G
H
F
D
K
--------
E
I
V
P
V
--------
L
V
S
TR
K
G
L
I
------
E
---------
V
K
T
---------
D
E
F
P
R
H
G
S
N
I
E
A
M
S
K
L
K
P
Y
F
L
T
D
-
G
T
G
T
V
T
P
A
N
A
S
G
I
N
D
G
A
A
A
V
V
L
M
K
K
S
E
A
D
K
R
G
L
T
P
L
A
R
I
V
S
W
S
Q
V
-
G
-
V
-
E
P
---
S
I
M
G
I
--
G
P
I
P
A
I
K
Q
A
V
T
K
A
G
W
S
L
E
D
V
D
I
F
E
I
N
E
A
F
A
A
V
S
A
A
I
V
---
K
E
L
G
L
--------------
N
P
E
K
V
N
I
E
G
G
A
I
A
L
G
H
P
L
G
A
S
G
C
R
I
L
V
T
L
L
H
T
L
E
R
M
-----
G
--
R
S
R
-
G
V
A
A
L
C
I
G
G
G
M
G
I
A
M
C
V
Q
R
22
HHSearch
87.17
30%
-69
- C1 -
2WU9
7
THIK2_ARATH
A:
[26-418]
--------
S
L
Y
G
D
D
V
V
I
V
A
A
H
R
T
P
L
C
K
S
K
R
-
G
N
F
K
D
T
Y
P
D
D
L
L
A
P
V
L
R
A
L
I
E
K
T
-
N
L
-
N
P
S
E
V
G
D
I
V
V
G
T
V
L
A
-
P
G
-
S
Q
R
-
A
S
E
C
R
M
A
A
F
Y
A
G
F
P
E
T
V
A
V
R
T
V
N
R
Q
C
S
S
G
L
Q
A
V
A
D
V
A
A
A
I
K
A
G
F
Y
D
I
G
I
G
A
G
L
E
S
M
T
T
N
P
M
A
W
E
-
G
S
V
------------------------
N
--
P
---
A
V
K
K
F
--------
A
Q
A
Q
N
C
L
L
P
M
G
V
T
S
E
N
V
A
Q
R
F
G
V
S
R
Q
E
Q
D
Q
A
A
V
D
S
H
R
K
A
A
A
A
T
A
A
G
K
F
K
D
--------
E
I
I
P
V
--------
K
T
K
L
V
D
PKTG
D
E
K
P
I
T
---------
V
S
V
---------
D
D
G
I
R
P
T
T
T
L
A
S
L
G
K
L
K
P
V
F
K
K
---
D
G
T
T
T
A
G
N
S
S
Q
V
S
D
G
A
G
A
V
L
L
M
K
R
S
V
A
M
Q
K
G
L
P
V
L
G
V
F
R
T
F
A
A
V
G
V
-
D
-
P
----
A
I
M
G
I
--
G
P
A
V
A
I
P
A
A
V
K
A
A
G
L
E
L
D
D
I
D
L
F
E
I
N
E
A
F
A
S
Q
F
V
Y
C
R
---
N
K
L
G
L
--------------
D
P
E
K
I
N
V
N
G
G
A
M
A
I
G
H
P
L
G
A
T
G
A
R
C
V
A
T
L
L
H
E
M
K
R
R
-----
G
K
D
C
R
F
-
G
V
V
S
M
C
I
G
T
G
M
G
A
A
A
V
F
E
R
43
HHSearch
86.98
30%
-62
* C1 *
4O9A
-
THIL_CUPNH
A:
[2-392]
------------
T
D
V
V
I
V
S
A
A
R
T
A
V
G
K
F
-
G
-
G
S
L
A
K
I
P
A
P
E
L
G
A
V
V
I
K
A
A
L
E
R
A
-
G
V
-
K
P
E
Q
V
S
E
V
I
M
G
Q
V
L
T
-
A
G
-
S
-
G
-
Q
N
P
A
R
Q
A
A
I
K
A
G
L
P
A
M
V
P
A
M
T
I
N
K
V
S
G
S
G
L
K
A
V
M
L
A
A
N
A
I
M
A
G
D
A
E
I
V
V
A
G
G
Q
E
N
M
S
A
A
P
H
V
L
P
G
S
R
D
G
----------
F
R
M
G
----
D
-
A
K
L
---
V
D
T
M
I
----
V
----
D
-
G
L
W
D
V
Y
N
Q
Y
H
M
G
I
T
A
E
N
V
A
K
E
Y
G
I
T
R
E
A
Q
D
E
F
A
V
G
S
Q
N
K
A
E
A
A
Q
K
A
G
K
F
D
E
--------
E
I
V
P
V
--------
L
--------------
I
P
Q
RK
G
D
P
V
A
F
K
T
---------
D
E
F
V
R
Q
G
A
T
L
D
S
M
S
G
L
K
P
A
F
D
K
---
A
G
T
V
T
A
A
N
A
S
G
L
N
D
G
A
A
A
V
V
V
M
S
A
A
K
A
K
E
L
G
L
T
P
L
A
T
I
K
S
Y
A
N
A
-
G
-
V
-
D
---
P
K
V
M
G
M
--
G
P
V
P
A
S
K
R
A
L
S
R
A
E
W
T
P
Q
D
L
D
L
M
E
I
N
E
A
F
A
A
Q
A
L
A
V
H
---
Q
Q
M
G
W
--------------
D
T
S
K
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
C
R
I
L
V
T
L
L
H
E
M
K
R
R
-----
D
--
A
K
K
-
G
L
A
S
L
C
I
G
G
G
M
G
V
A
L
A
V
E
R
23
HHSearch
86.52
30%
-68
- C1 -
2IIK
-
THIK_HUMAN
A:
[33-422]
---------
A
S
A
A
D
V
V
V
V
H
G
R
R
T
A
I
C
R
A
G
R
-
G
G
F
K
D
T
T
P
D
E
L
L
S
A
V
M
T
A
V
L
K
D
V
-
N
L
-
R
P
E
Q
L
G
D
I
C
V
G
N
V
L
Q
-
P
G
-
A
-
G
-
A
I
M
A
R
I
A
Q
F
L
S
D
I
P
E
T
V
P
L
S
T
V
N
R
Q
C
S
S
G
L
Q
A
V
A
S
I
A
G
G
I
R
N
G
S
Y
D
I
G
M
A
C
G
V
E
S
M
S
L
A
D
-----
G
N
I
-----------------------
T
S
R
----
L
M
E
K
E
----------
K
A
R
D
C
L
I
P
M
G
I
T
S
E
N
V
A
E
R
F
G
I
S
R
E
K
Q
D
T
F
A
L
A
S
Q
Q
K
A
A
R
A
Q
S
K
G
C
F
Q
A
--------
E
I
V
P
V
--------
T
T
T
V
H
D
DKG
T
K
R
S
I
-
T
---------
V
T
Q
---------
D
E
G
I
R
P
S
T
T
M
E
G
L
A
K
L
K
P
A
F
K
K
---
D
G
S
T
T
A
G
N
S
S
Q
V
S
D
G
A
A
A
I
L
L
A
R
R
S
K
A
E
E
L
G
L
P
I
L
G
V
L
R
S
Y
A
V
V
G
V
-
P
-
P
----
D
I
M
G
I
--
G
P
A
Y
A
I
P
V
A
L
Q
K
A
G
L
T
V
S
D
V
D
I
F
E
I
N
E
A
F
A
S
Q
A
A
Y
C
V
---
E
K
L
R
L
--------------
P
P
E
K
V
N
P
L
G
G
A
V
A
L
G
H
P
L
G
C
T
G
A
R
Q
V
I
T
L
L
N
E
L
K
R
R
-----
G
K
-
R
A
Y
-
G
V
V
S
M
C
I
G
T
G
M
G
A
A
A
V
F
E
Y
8
PsiBlast_PDB
86.10
27%
-70
- C1 -
2C7Z
-
THIK2_ARATH
A:
[41-437]
---
A
Y
Q
R
T
S
L
Y
G
D
D
V
V
I
V
A
A
H
R
T
P
L
C
K
S
-
K
R
G
N
F
K
D
T
Y
P
D
D
L
L
A
P
V
L
R
A
L
I
E
K
T
-
N
L
N
P
S
E
V
G
D
I
V
V
G
T
V
L
A
P
-
G
S
-
Q
-
R
-
A
S
E
C
R
M
A
A
F
Y
A
G
F
P
E
T
V
A
V
R
T
V
N
R
Q
C
S
S
G
L
Q
A
V
A
D
V
A
A
A
I
K
A
G
F
Y
D
I
G
I
G
A
G
L
E
S
M
T
T
N
P
M
A
W
E
------------------
K
K
F
A
Q
A
Q
N
C
L
---------------------------
L
P
M
G
V
T
S
E
N
V
A
Q
R
F
G
V
S
R
Q
E
Q
D
Q
A
A
V
D
S
H
R
K
A
A
A
A
T
A
A
G
K
F
K
D
E
I
I
P
V
K
T
K
L
V
D
P
K
--------
T
--------------
G
DE
K
P
I
T
---
V
S
V
---------
D
D
G
I
R
P
T
T
T
L
A
S
L
G
K
L
K
P
V
F
---
K
K
D
G
T
T
T
A
G
N
S
S
Q
V
S
D
G
A
G
A
V
L
L
M
K
R
S
V
A
M
Q
K
G
L
P
V
L
G
V
F
R
T
F
A
A
V
G
V
-
D
-
P
A
I
----
M
G
I
--
G
P
A
V
A
I
P
A
A
V
K
A
A
G
L
E
L
D
D
I
D
L
F
E
I
N
E
A
F
A
S
Q
F
V
----------
Y
C
R
N
K
L
G
L
D
P
-------
E
K
I
N
V
N
G
G
A
M
A
I
G
H
P
L
G
A
T
G
A
R
C
V
A
T
L
L
H
E
M
------
K
R
R
G
K
D
C
R
F
G
V
V
S
M
C
I
G
T
G
M
G
A
A
A
V
F
E
-
9
PsiBlast_PDB
86.08
27%
-75
- C1 -
2WU9
7
THIK2_ARATH
A:
[26-417]
--------
S
L
Y
G
D
D
V
V
I
V
A
A
H
R
T
P
L
C
K
S
-
K
R
G
N
F
K
D
T
Y
P
D
D
L
L
A
P
V
L
R
A
L
I
E
K
T
-
N
L
N
P
S
E
V
G
D
I
V
V
G
T
V
L
A
P
-
G
S
-
Q
-
R
-
A
S
E
C
R
M
A
A
F
Y
A
G
F
P
E
T
V
A
V
R
T
V
N
R
Q
C
S
S
G
L
Q
A
V
A
D
V
A
A
A
I
K
A
G
F
Y
D
I
G
I
G
A
G
L
E
S
M
T
T
N
P
M
A
W
E
-
G
S
V
N
----------
P
A
V
K
K
F
A
Q
A
Q
N
C
L
---------------------------
L
P
M
G
V
T
S
E
N
V
A
Q
R
F
G
V
S
R
Q
E
Q
D
Q
A
A
V
D
S
H
R
K
A
A
A
A
T
A
A
G
K
F
K
D
E
I
I
P
V
K
T
K
L
V
D
P
K
--------
T
--------------
G
D
E
K
P
I
T
---
V
S
V
---------
D
D
G
I
R
P
T
T
T
L
A
S
L
G
K
L
K
P
V
F
---
K
K
D
G
T
T
T
A
G
N
S
S
Q
V
S
D
G
A
G
A
V
L
L
M
K
R
S
V
A
M
Q
K
G
L
P
V
L
G
V
F
R
T
F
A
A
V
G
V
-
D
-
P
A
I
----
M
G
I
--
G
P
A
V
A
I
P
A
A
V
K
A
A
G
L
E
L
D
D
I
D
L
F
E
I
N
E
A
F
A
S
Q
F
V
----------
Y
C
R
N
K
L
G
L
D
P
-------
E
K
I
N
V
N
G
G
A
M
A
I
G
H
P
L
G
A
T
G
A
R
C
V
A
T
L
L
H
E
M
------
K
R
R
G
K
D
C
R
F
G
V
V
S
M
C
I
G
T
G
M
G
A
A
A
V
F
E
-