@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0386: (2016-04-22 )
MSKLLPRGTVTLLLADVEGSTWLWETHPDDMGAAVARLDKAVSGVIAAHDGVRPVEQGEGDSFVLAFACASDAVAAALDLQRARLAPIRLRIGVHTGEVALRDEGNYAGPTINRTARLRDLAHGGQTVLSGVTESLVIDRLPDKAWLVDLGTHALRDLSRPERVMQLCHPELRIDFPPLRVANDDVAHGLPVHLTRFVGRGAQITEVHRLVTDNRLVTLTGAGGVGKTRLAAQLAAQIAGEFGRAWFVDLAPITDPDLVPVTVAGALGLHDQPGRSTTDTVLRFLGGRPALVVLDNCEHLLDATAALVLALVKACRGVRLLATCREPLRVEGEVSYRVPSLSLSDEAVEMFCYRAQRVRPDFRLTDDNSAAVTEICKRLDGLPLAIELAAARLRSMTLDEIIDGLRDRFALLTGGARTAAHRQQTLWASVDWSYTLLTEPERTLFRRLAVFVGCFFVDDAQAVACSGDVQRYQVLDEITLLVDKSLVMADDNSGRTCYRLCETMRHYALEKLSEAGEVDAVFARHRDYYTALAARVDNPGPSDYSHCLDQAETEIDNLRAAFVWNRENSDTEGALALASSLLRVWMTRGRIQEGRAWFDSILADENARHLEVAAAVRARALADKALLDIFVDAAAGMEQAQQALVIAREVDEPALLSRALTACGLIAVAVARADAAASYFAEAIDLARAVDDRWRLAQILTFQAVDAVVAGDPVAARPAAQEARELAAAIGDHSNALWCRWCLGYAQLMRGELAAAAAQFGEVVDEAEASQEVLHKANSLQGLAFALAYQGELSAARAAADAALEAAELGEYFAGMGYSALTTAALAAGDVQTAQHASEAAWRNLSLALPLSAAVQRAFNAQAALAGGDLSAARRWCDDAVQSMTGHHLAMALATRARIAVAEGKREEAERDAHKALACAAESGAHLDLPDVLECLAGLASDAGTHHAAARLFGAAEAIRQQIGSVRFAIYRSDYVQSVTALRDAMGEKDFDAAWAEGAALSIKETIAYAQRGHSWRKRPATGWESLTPTEIDVVRLVGEGLANKDIATRLFVSPRTVQTHLTHVYTKLGFTSRLQLAQAAARRT
Atome Classification :
(20 SA)
---.........10........20....-..---..30...-.....40........50-..-.......60.......-------.-------70--------..-------.......80----------------------------------..-------.-----------.-------------------------------------------.-------------------------------------------.---------..90........100-.-------.-------.-----.-------...110.......120.......130.......140.........150......---.160......--------.170.......180.......190.......200.......210----.----......220.......230..----.....240-...-......250..--.....260.......-----------270-------.......280...--....290.......300.......310.......320...-----....330---.......-.340.......350.......360.......370.......380.......390.....--..400.......410.......420.......430.......440.......450-........460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630....-...640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750------------.......760.......--770.......780.......790.......800...-....810.-......820.......830.......840.......-850........860.......870.......880..--..----...890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---MSKLLPR
G
T
V
T
L
L
L
ADVEG
S
T
W
L
W
E-TH---P
D
D
M
G
A
A
-
V
A
R
L
D
K
A
V
S
G
V
I
AAHD--GV-RPVEQGEGD
S
F
V
L
A
F
A-------C-------A---------
S
D
-------
A
V
A
A
A
L
D
L
Q
----------------------------------RA-------R-----------L-------------------------------------------
A
-------------------------------------------
P
---------
I
R
L
R
I
G
V
H
T
G
E
V
A
L
R-D-------E-------G-----N-------YAGPTIN
R
T
A
R
L
R
D
L
AHG
G
Q
T
V
L
S
G
V
T
E
S
L
V
IDR--LPDK
A
W
L
V
D
L
G
T
H
A
L
R
DL---S
R
P
E
R
V
M
Q
LC--------HP
E
L
R
IDFPPLRVANDDVAHGL
P
V
H
L
T
R
F
VGRGA
Q
I
T
E
V
H
R
L
VT----D----N
R
L
V
T
L
TGAGGV
G
K
T
R
L
A
A
Q
L
----
A
A
Q
I
A
G
---EFG-
R
A
W
F
V
D
LAPIT--DP
D
L
V
P
V
T
V
A
GALGL-----------HDQ-------PGR
S
T
T
D
T
V
L
R
F
L--GGR
P
A
L
V
V
LDN
C
E
H
L
L
D
A
T
A
A
L
V
L
A
L
V
K
A
CRG
V
R
L
L
A
TCR-----E
P
L
R
VE----
G
E
V
S
Y
RV-PSLSL
S
D
E
A
V
E
M
F
C
Y
R
A
Q
RVRP
D
F
R
LTDDN
S
A
A
V
T
E
I
C
K
RLDGL
P
L
A
I
E
L
A
A
A
R
L
R
SM
T
--
L
D
E
I
I
D
G
L
R
D
R
F
A
L
LTGGART
A
A
HRQ
Q
T
L
W
A
SV
D
W
S
Y
T
L
LTE
P
E
R
T
L
F
R
R
L
A
V
F
--
V
G
C
F
F
VDDA
Q
A
V
ACSG
D
V
Q
R
Y
Q
V
L
D
E
I
T
L
L
VDK
S
L
V
M
ADDNSG
R
T
C
Y
R
L
C
E
T
M
R
H
Y
A
L
E
K
L
S
EAGE
V
D
A
V
F
A
R
H
R
D
Y
Y
T
A
L
A
A
RVDNPGP
S
D
Y
S
H
C
L
D
Q
A
E
T
E
I
DN
L
R
A
A
F
V
WNRENSDT
E
G
A
L
A
L
A
S
S
L
L
R
V
W
M
TRGRIQ
E
G
R
A
W
F
D
S
I
LADENA
R
H
L
E
V
A
A
A
V
R
A
R
A
L
A
D
K
A
L
L
D
I
F
V
D
A
AA
G
-
M
E
Q
A
Q
Q
A
L
V
I
A
REVD
E
P
A
L
L
S
R
A
L
T
A
C
G
L
I
A
V
A
V
A
R
A
D
A
A
A
S
Y
F
A
E
A
I
D
L
A
R
A
V
D
D
R
W
R
L
A
Q
I
L
T
F
Q
A
V
D
A
V
VAGDPVAAR
P
A
A
Q
E
A
R
E
L
A
A
A
IGDHSN
A
L
W
C
R
W
C
L
G
Y
A
Q
L
M
R
G
E
------------
L
A
A
A
A
A
Q
F
G
E
V
V
D
E
A
E
A
--
S
Q
E
V
L
H
K
A
NSL
Q
G
L
A
F
A
L
A
YQGE
L
S
A
A
R
A
A
A
D
A
A
L
E
-
A
A
E
L
G
E
Y
F
-
A
GMG
Y
S
A
L
T
T
A
A
LAAGD
V
Q
T
A
Q
H
A
S
E
A
A
WRN
L
S
L
AL-
P
L
-
S
A
A
V
Q
R
A
FNAQAALAGG
D
L
S
A
A
R
R
W
C
D
D
A
V
Q
S
M--T
G
----
H
H
L
A
M
A
L
A
TR
A
R
I
A
VAEG
K
R
E
E
A
E
R
D
A
H
K
A
L
A
CAAESGAHL
D
L
P
D
V
L
E
C
L
A
G
L
ASDAG
T
H
H
A
A
A
R
L
F
G
A
A
E
A
I
R
Q
Q
IGS
V
R
F
A
I
Y
R
S
D
Y
V
Q
S
V
T
A
L
R
D
A
MGEKDF
D
A
A
WAEGA
A
L
S
I
K
E
T
I
A
Y
A
QRGHSWRKRPATGWESLTPT
E
I
D
V
V
R
L
V
G
EGLANK
D
I
A
T
R
L
FVSP
R
T
V
Q
T
H
L
T
H
V
Y
T
KLG
F
T
S
R
L
Q
L
A
Q
A
A
ARRT
66
HHSearch
84.19
34%
-46
* C1 *
1FX2
2
A:
[8-220]
-------
E
P
T
D
P
V
T
L
I
F
T
D
I
E
S
S
T
A
L
W
A
-
A
H
---
P
D
L
M
P
D
A
-
V
A
A
H
H
R
M
V
R
S
L
I
G
R
Y
K
--
C
Y
---
E
V
K
T
V
G
D
S
F
M
I
A
S
K
-------
S
-------
P
---------
F
A
-------
A
V
Q
L
A
Q
E
L
Q
----------------------------------
L
C
-------
F
-----------
L
H
HDWGTN
A
L
D
D
S
Y
R
E
F
E
E
Q
R
A
E
G
E
C
EYTPPTAHMD
P
E
V
Y
S
R
L
W
N
-------------------------------------------
G
---------
L
R
V
R
V
G
I
H
T
G
L
C
D
I
R
-
H
DEVTK--
G
-------
Y
-----
D
-------
Y
Y
G
R
T
P
N
M
A
A
R
T
E
S
V
A
N
G
G
Q
V
L
M
T
H
A
A
Y
M
S
L
S
A
E
--
D
R
K
Q
I
D
V
T
A
L
G
D
V
A
L
R
G
V
---
S
D
P
V
K
M
Y
Q
L
N
--------
T
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
Fugue
83.56
32%
-41
- C1 -
1FX2
2
A:
[1-235]
NNN
R
A
P
K
E
P
T
D
P
V
T
L
I
F
T
D
I
E
S
S
T
A
L
W
A
-
A
H
---
P
D
L
M
P
D
A
-
V
A
A
H
H
R
M
V
R
S
L
I
G
R
Y
K
--
C
---
Y
E
V
K
T
V
G
D
S
F
M
I
A
S
K
-------
S
-------
P
---------
F
A
-------
A
V
Q
L
A
Q
E
L
Q
----------------------------------
L
C
-------
F
-----------
L
-------------------------------------------
H
HDWGTN
A
L
D
D
S
Y
R
E
F
E
E
Q
R
A
E
G
E
C
EYTPPTAHMD
P
E
V
Y
S
R
L
WN
G
---------
L
R
V
R
V
G
I
H
T
G
L
C
D
I
R
-
H
-------
D
-------
E
VTK
G
Y
D
-------
Y
Y
G
R
T
P
N
M
A
A
R
T
E
S
V
A
N
G
G
Q
V
L
M
T
H
A
A
Y
M
S
L
S
A
E
--
D
R
K
Q
I
D
V
T
A
L
G
D
V
A
L
R
G
V
---
S
D
P
V
K
M
Y
Q
L
N
T
VPS
R
N
F
A
A
L
R
L
D
R
E
Y
F
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
76.05
27%
-49
- C1 -
1FX2
2
A:
[9-216]
--------
P
T
D
P
V
T
L
I
F
T
D
I
E
S
S
T
A
L
W
A
-
A
H
---
P
D
L
M
P
D
A
-
V
A
A
H
H
R
M
V
R
S
L
I
G
R
Y
K
CY
E
V
-
K
T
V
----
G
D
S
F
M
I
A
S
K
-------
S
-------
P
---------
F
A
-------
A
V
Q
L
A
Q
E
L
Q
L
C
F
L
H
HDWGTN
A
L
D
D
S
Y
R
E
F
E
E
Q
R
A
E
G
E
C
EYTPP
T
A
-------
H
-----------
M
-------------------------------------------
D
-------------------------------------------
P
E
V
Y
S
R
L
WN
G
L
R
V
R
V
G
I
H
T
G
L
C
D
I
R
-
H
-------
D
-------
E
VTK
G
Y
D
-------
Y
Y
G
R
T
P
N
M
A
A
R
T
E
S
V
A
N
G
G
Q
V
L
M
T
H
A
A
Y
M
S
L
S
A
E
--
D
R
K
Q
I
D
V
T
A
L
G
D
V
A
L
R
G
V
---
S
D
P
V
K
M
Y
Q
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
Fugue
74.89
13%
-48
- C2 -
1Z6T
1
APAF_HUMAN
A:
[1-586]
------------------------------------------------------------------------------------------------------------------------
M
D
----------------------------------
A
K
-------
A
-----------
R
-------------------------------------------
N
-------------------------------------------
C
---------
L
L
Q
H
R
E
A
L
E
K
D
I
K
T
S
-
Y
-------
I
-------
M
-----
D
-------
H
M
I
S
D
G
F
L
T
I
S
E
E
E
K
V
R
N
E
P
T
Q
Q
Q
R
A
A
M
L
I
K
M
I
L
--
K
K
D
N
D
S
Y
V
S
F
Y
N
A
L
L
H
E
G
---
Y
--
K
D
L
A
A
L
L
--------
H
D
G
I
P
V
V
G
I
T
S
Y
V
R
T
V
L
C
E
G
G
V
P
Q
R
P
V
V
F
V
T
R
K
K
L
V
N
A
I
Q
Q
K
L
S
----
K
LKG
E
P
G
W
V
T
I
H
G
M
A
G
C
G
K
S
V
L
A
A
E
A
V
RD
H
S
L
L
E
G
C
---
F
P
G
-
G
V
H
W
V
S
V
G
K
Q
D
--
K
S
G
L
L
M
K
L
Q
N
L
C
T
R
L
D
Q
DESFSQRLP
L
N
I
-------
E
E
A
K
D
R
L
R
I
L
M
L
R
--
K
H
P
R
S
L
L
I
L
D
D
---
V
W
D
S
W
V
L
K
A
F
D
S
-----
Q
C
Q
I
L
L
T
T
R
DKSVT
D
S
V
M
G
P
----
K
Y
V
V
P
V
E
-
S
S
L
G
-
K
E
K
G
L
E
I
L
S
L
F
V
N
M
K
K
A
D
L
P
------
E
Q
A
H
S
I
I
K
E
C
K
G
S
P
L
V
V
S
L
I
G
A
L
L
R
D
F
P
--
N
R
W
E
Y
Y
L
K
Q
L
Q
N
K
Q
F
K
R
I
R
K
S
S
S
Y
D
Y
E
A
L
D
E
A
M
S
I
S
V
E
M
L
R
E
D
I
K
D
Y
Y
T
D
L
S
I
L
--
Q
K
D
V
K
V
P
T
K
V
L
C
I
L
W
-
D
M
E
T
E
E
V
E
D
I
L
Q
E
F
V
N
K
S
L
L
F
C
D
R
N
G
K
S
F
R
Y
Y
L
H
D
L
Q
V
D
F
L
T
E
K
-
N
C
S
Q
L
Q
D
L
H
K
K
I
I
T
Q
F
Q
R
Y
H
Q
P
H
T
L
S
P
D
Q
E
D
C
M
Y
W
Y
N
F
L
A
Y
H
M
A
S
A
K
M
H
K
E
L
C
A
L
M
F
S
L
D
W
I
K
A
K
T
E
L
V
G
P
A
H
L
I
H
E
F
V
E
Y
R
H
I
L
--
D
E
K
D
C
A
V
S
E
N
F
Q
E
F
L
S
L
N
G
H
L
L
G
R
Q
P
F
P
N
I
V
Q
L
G
L
C
E
-
P
E
T
S
E
V
Y
Q
Q
A
K
L
Q
A
K
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
73.78
28%
-51
- C1 -
1FX4
1
A:
[9-216]
--------
P
T
G
P
V
T
L
I
F
T
D
I
E
S
S
T
A
L
W
A
-
A
H
---
P
D
L
M
P
D
A
-
V
A
T
H
H
R
L
I
R
S
L
I
T
R
Y
E
CY
E
V
-
K
T
V
----
G
D
S
F
M
I
A
S
K
-------
S
-------
P
---------
F
A
-------
A
V
Q
L
A
Q
E
L
Q
L
C
F
L
R
LDWETN
A
V
D
E
S
Y
R
E
F
E
E
Q
R
A
E
G
E
CEYTPP
T
A
-------
S
-----------
L
-------------------------------------------
D
-------------------------------------------
P
E
V
Y
S
R
L
WN
G
L
R
V
R
V
G
I
H
T
G
L
C
D
I
R
Y
D
-------
E
VTK
G
---
Y
-----
D
-------
Y
Y
G
R
T
S
N
M
A
A
R
T
E
S
V
A
N
G
G
Q
V
L
M
T
H
A
A
Y
M
S
L
S
G
E
--
D
R
N
Q
L
D
V
T
T
L
G
A
T
V
L
R
G
V
---
P
E
P
V
R
M
Y
Q
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
HHSearch
72.76
24%
-41
- C1 -
2W01
-
?
A:
[437-623]
-------
G
D
R
R
P
I
T
I
L
T
S
D
L
R
G
F
T
S
T
S
E
-
G
L
N--
P
E
E
V
V
K
V
-
L
N
I
Y
F
G
K
M
A
D
V
I
T
H
H
G
--
G
T
---
I
D
E
F
M
G
D
G
I
L
V
L
F
G
-------
A
-------
P
TSQQD
D
A
--
L
R
-------
A
V
A
C
G
V
E
M
Q
----------------------------------
L
A
-------
L
-----------
R
E
V
N
Q
Q
V
T
G
L
G
L
--------------------------------
Q
-------------------------------------------
P
---------
L
E
M
G
I
G
I
N
T
G
E
V
V
V
G
-
N
I
G
S
EKRT
K
-------
Y
-----
G
-------
V
V
G
A
Q
V
N
L
T
Y
R
I
E
S
Y
T
T
G
G
Q
I
F
I
S
S
T
T
L
E
A
A
G
------
D
R
V
H
V
N
G
N
R
T
V
Q
P
K
G
V
---
K
D
P
V
V
I
W
D
V
A
--------
G
V
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
HHSearch
69.96
19%
-48
- C1 -
4NI2
3
A:
[10-193]
-------
K
K
F
S
N
V
T
M
L
F
S
D
I
V
G
F
T
A
I
C
S
-
Q
C
S--
P
L
Q
V
I
T
M
-
L
N
A
L
Y
T
R
F
D
Q
Q
C
G
E
L
D
--
V
Y
---
K
V
E
T
I
G
D
A
Y
C
V
A
G
G
LHKESDT
H
-------
A
---------
V
Q
-------
I
A
L
M
A
L
K
M
M
----------------------------------
E
L
-------
S
-----------
D
E
V
MSPHG------------------------------------
E
-------------------------------------------
P
---------
I
K
M
R
I
G
L
H
S
G
S
V
F
A
G
-
V
-------
V
G
VKM
P
R
-
Y
-----
C
-------
L
F
G
N
N
V
T
L
A
N
K
F
E
S
C
S
V
P
R
K
I
N
V
S
P
T
T
Y
R
L
L
K
D
C
----
P
G
F
V
F
T
P
R
S
R
E
E
L
P
P
N
FPS
E
I
P
G
I
C
H
F
L
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
HHSearch
69.33
18%
-85
- C2 -
1Z6T
1
APAF_HUMAN
A:
[119-449]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
Q
R
P
V
V
F
V
T
R
K
K
L
V
N
A
I
Q
Q
K
L
S
K
LKG
E
----
P
G
W
V
T
I
H
G
M
A
G
C
G
K
S
V
L
A
A
E
A
----
V
R
D
H
S
L
L
E
G
C
F
P
G
G
V
H
W
V
S
V
G
K
Q
D
K
S
G
L
L
M
K
L
Q
N
L
C
T
R
L
D
Q
-----------
D
E
S
FSQRLPL
N
I
E
E
A
K
D
R
L
R
I
L
M
L
R
K
H
P
R
S
L
L
I
L
D
D
V
W
D
S
W
V
-----
L
K
A
F
---
D
S
Q
C
Q
I
L
L
T
T
R
-----
D
K
S
V
T
D
SVM
G
P
K
Y
V
V
P
V
E
S
S
L
G
K
E
-
K
G
L
E
I
L
S
L
F
V
N
M
K
------
K
A
D
L
P
E
Q
A
H
S
I
I
K
E
C
K
G
S
P
L
V
V
S
L
I
G
A
L
L
R
D
F
P
NR
W
E
Y
Y
L
K
Q
L
Q
N
K
Q
F
K
R
I
--
R
K
S
S
S
Y
D
Y
E
A
L
D
E
A
M
S
I
S
V
E
M
L
R
E
D
I
K
D
Y
Y
T
D
L
S
I
L
QK
D
V
K
V
P
T
K
V
L
C
I
L
W
D
M
---
E
T
E
E
V
E
D
I
L
Q
E
F
V
N
K
S
L
L
F
C
D
R
N
G
K
S
F
R
Y
Y
L
H
D
L
Q
V
D
F
L
T
E
K
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
HHSearch
68.61
29%
-43
- C1 -
4WP9
6
?
A:
[4-173]
-------
A
M
G
S
R
V
V
I
L
F
T
D
I
E
E
S
T
A
L
N
E
-
R
I
G--
D
R
A
W
V
K
L
-
I
S
S
H
D
K
L
V
S
D
L
V
R
R
Q
S
--
G
H
---
V
V
K
S
Q
G
D
G
F
M
V
A
F
A
-------
R
-------
P
---------
E
Q
-------
A
V
R
C
G
I
E
L
Q
----------------------------------
R
A
-------
L
-----------
R
R
N
A------------------------------------------------------------------------------------
E
---------
I
R
V
R
I
G
I
H
M
G
R
S
V
R
R
-
G
---------------
D
-----
D
-------
L
F
G
R
N
V
A
M
A
A
R
V
A
A
Q
A
A
G
G
E
I
L
V
S
Q
P
V
R
D
A
L
S
R
S
----
D
G
I
R
F
D
D
G
R
E
V
E
L
K
G
F
---
S
G
T
Y
R
L
F
A
V
L
--------
A
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
HHSearch
68.35
17%
-44
- C1 -
3UVJ
3
GCYA3_HUMAN
A:
[10-196]
-------
K
K
F
S
N
V
T
M
L
F
S
D
I
V
G
F
T
A
I
C
S
-
Q
C
S--
P
L
Q
V
I
T
M
-
L
N
A
L
Y
T
R
F
D
Q
Q
C
G
E
L
D
--
V
Y
---
K
V
E
T
I
G
D
A
Y
C
V
A
G
G
LHKESDT
H
-------
A
---------
V
Q
-------
I
A
L
M
A
L
K
M
M
----------------------------------
E
L
-------
S
-----------
D
E
VMSPHG------------------------------------
E
-------------------------------------------
P
---------
I
K
M
R
I
G
L
H
S
G
S
V
F
A
G
-
V
V
G
VM
P
--
R
-------
Y
-----
C
-------
L
F
G
N
N
V
T
L
A
N
K
F
E
S
C
S
V
P
R
K
I
N
V
S
P
T
T
Y
R
L
L
K
D
C
----
P
G
F
V
F
T
P
R
S
R
E
E
L
P
P
N
FPS
E
I
P
G
I
C
H
F
L
D
--------
A
Y
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
HHSearch
67.91
17%
-46
- C1 -
1HZ4
10
A:
[21-333]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
V
A
I
N
D
G
N
P
D
E
A
E
R
L
A
K
L
A
L
E
E
L
P
P
-
G
W
F
Y
S
R
I
V
A
T
S
V
L
G
E
V
L
H
C
K
G
E
L
T
R
S
L
A
L
M
Q
Q
T
E
Q
M
A
R
Q
H
D
V
W
H
Y
A
L
W
S
L
I
Q
Q
S
E
I
L
F
A
Q
G
F
------------
L
Q
T
A
W
E
T
Q
E
K
A
F
Q
L
I
N
E
Q
H
L
E
Q
L
P
M
H
E
F
L
V
R
I
R
A
Q
L
L
W
A
W
A
R
L
D
E
A
E
A
S
A
R
S
G
I
E
V
L
S
S
Y
Q
P
Q
Q
-
Q
L
Q
C
L
A
M
L
I
Q
C
S
L
A
R
G
D
L
D
N
A
R
S
Q
L
N
R
L
E
N
L
L
G
N
G
K
Y
H
S
D
W
I
S
N
A
N
K
V
R
V
I
Y
W
Q
M
T
G
D
K
A
A
A
A
N
W
L
R
H
T
A
K
P
E
FA
N
N
----
H
F
L
Q
G
Q
W
R
N
I
A
R
A
Q
I
L
L
G
E
F
E
P
A
E
I
V
L
E
E
L
N
E
N
A
R
S
L
R
L
M
S
D
L
N
R
N
L
L
L
L
N
Q
L
Y
W
Q
A
G
R
K
S
D
A
Q
R
V
L
L
D
A
L
K
L
A
N
R
T
G
F
I
S
H
F
V
-------------------------------------------------------------------------------------------------------------------
79
HHSearch
67.29
23%
-55
- C1 -
3R5G
1
?
A:
[5-193]
-------
T
Q
R
K
K
L
T
V
F
F
S
D
I
R
G
F
T
E
L
S
E
-
E
L
E--
A
E
A
L
T
D
L
-
L
N
N
Y
L
N
E
M
S
K
I
A
L
K
Y
G
--
G
T
---
I
D
K
F
V
G
D
C
V
M
V
F
F
G
-------
D
-------
P
STQG
A
K
K
D
A
V
A
-------
A
V
S
M
G
I
A
M
R
----------------------------------
K
H
-------
M
-----------
K
V
L
R
Q
Q
W
R
A
Q
GIT-------------------------------
K
-------------------------------------------
P
---------
L
E
I
R
M
G
I
N
T
G
Y
C
T
V
G
-
N
-------
F
G
A
DTRMD
Y
-----
T
-------
I
I
G
R
E
V
N
L
A
S
R
L
E
S
A
S
E
A
G
E
I
L
I
S
H
E
T
Y
S
L
I
K
------
D
V
I
M
C
R
D
K
G
Q
I
A
V
K
G
F
---
S
R
P
V
Q
I
Y
Q
V
V
--------
D
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
HHSearch
66.36
18%
-39
- C1 -
4WND
19
GPSM2_HUMAN
A:
[12-341]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
E
G
E
R
L
C
K
S
G
D
C
R
A
G
V
S
F
F
E
A
A
V
Q
V
G
T
E
--
D
L
K
T
L
S
A
I
Y
S
Q
L
G
N
A
Y
F
Y
L
H
D
Y
A
K
A
L
E
Y
H
H
H
D
L
T
L
A
R
T
I
G
D
Q
L
G
E
A
K
A
S
G
N
L
G
N
T
L
K
V
L
G
N
F
D
E
A
I
V
C
C
Q
R
H
L
D
I
S
R
E
L
N
D
K
V
G
E
A
R
A
L
Y
N
L
G
N
V
Y
H
A
K
G
K
S
F
GCFP
E
E
V
R
D
A
L
Q
A
A
V
D
F
Y
E
E
N
L
S
L
V
T
A
--
L
G
D
R
A
A
Q
G
R
A
F
G
N
L
G
N
T
H
Y
L
L
G
N
F
R
D
A
V
I
A
H
E
Q
R
L
L
I
A
K
E
F
G
D
K
A
A
E
R
R
A
Y
S
N
L
G
N
A
Y
I
F
L
G
E
F
E
T
A
S
E
Y
Y
K
K
T
L
L
L
A
R
Q
L
K
D
R
A
-
V
E
A
Q
S
C
Y
S
L
G
N
T
Y
T
L
L
Q
D
Y
E
K
A
I
D
Y
H
L
K
H
L
A
I
A
--
Q
E
L
ND
R
I
G
E
G
R
A
C
W
S
L
G
N
A
Y
T
A
L
G
N
H
D
Q
A
M
H
F
A
E
K
H
L
E
I
S
R
E
V
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
71
HHSearch
63.62
19%
-34
- C1 -
2WZ1
2
GCYB1_HUMAN
A:
[9-201]
--------
R
Y
D
N
V
T
I
L
F
S
G
I
V
G
F
N
A
F
C
S
-
K
H
ASG
A
M
K
I
V
N
L
-
L
N
D
L
Y
T
R
F
D
T
L
T
D
S
R
K
--
N
P
F
V
Y
K
V
E
T
V
G
D
K
Y
M
T
V
S
G
-------
L
PEPCIH
H
A
---------
R
S
-------
I
C
H
L
A
L
D
M
M
----------------------------------
E
I
-------
A
-----------
G
Q
VQVDG-------------------------------------
E
-------------------------------------------
S
---------
V
Q
I
T
I
G
I
H
T
G
E
V
V
T
G
-
V
I
G
QRM
P
-
R
-------
Y
-----
C
-------
L
F
G
N
T
V
N
L
T
S
R
T
E
T
T
G
E
K
G
K
I
N
V
S
E
Y
T
Y
R
C
L
M
S
P
EN
S
D
P
Q
F
H
L
E
H
R
G
P
V
S
M
K
G
K
---
K
E
P
M
Q
V
W
F
L
S
--------
R
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
61.72
24%
-43
- C1 -
2W01
-
?
A:
[439-597]
---------
R
R
P
I
T
I
L
T
S
D
L
R
G
F
T
S
T
S
E
G
L
N
---
P
E
E
V
V
K
V
-
L
N
I
Y
F
G
K
M
A
D
V
I
T
H
H
G
--
G
T
---
I
D
E
F
M
G
D
G
I
L
V
L
F
G
-------
A
-------
P
---------
T
S
QQD
D
A
L
R
A
V
A
C
G
V
E
M
Q
----------------------------------
L
A
-------
L
R
E
V
N
Q
Q
V
T
G
L
G
L
-------------------------------------------
Q
-------------------------------------------
P
---------
L
E
M
G
I
G
I
N
T
G
E
V
V
V
G
-
N
-------
I
-------
G
-----
S
EKRTKYG
V
V
G
A
Q
V
N
L
T
Y
R
I
E
S
Y
T
T
G
G
Q
I
F
I
S
S
T
T
L
E
A
A
G
D
R
--
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
HHSearch
61.42
19%
-46
- C1 -
1WC3
3
?
A:
[22-214]
------
R
P
E
P
R
L
I
T
I
L
F
S
D
I
V
G
F
T
R
M
S
N
-
A
L
Q--
S
Q
G
V
A
E
L
-
L
N
E
Y
L
G
E
M
T
R
A
V
F
E
N
Q
--
G
T
---
V
D
K
F
V
G
D
A
I
M
A
L
Y
G
-------
A
-------
P
E
E
M
S
P
S
E
Q
V
R
R
-------
A
I
A
T
A
R
Q
M
L
----------------------------------
V
A
-------
L
-----------
E
K
L
N
Q
G
W
Q
E
R
GLVGRNEV--------------------------
P
-------------------------------------------
P
---------
V
R
F
R
C
G
I
H
Q
G
M
A
V
V
G
-
L
FGSQE
R
S
D
-------
F
-----
T
-------
A
I
G
P
S
V
N
I
A
A
R
L
Q
E
A
T
A
P
N
S
I
M
V
S
A
M
V
A
Q
Y
V
P
------
D
E
E
-
I
I
K
R
E
F
L
E
L
K
G
I
---
D
E
P
V
M
T
C
V
I
N
--------
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
60.63
32%
-21
- C1 -
4WP3
1
?
C:
[33-169]
---
L
A
R
V
T
P
D
G
R
V
V
I
L
F
T
D
I
E
E
S
T
A
L
N
E
-
R
I
---
G
D
R
A
W
V
K
L
I
S
S
H
D
K
L
V
S
D
L
V
R
R
Q
S
--
G
---
H
V
V
K
S
Q
G
D
G
F
M
V
A
F
A
-------
R
-------
P
---------
E
Q
-------
A
V
R
C
G
I
E
L
Q
----------------------------------
R
A
L
R
R
N
A
N
R--------------------------------------------------------
E
-------------------------------------------
E
---------
I
R
V
R
I
G
I
H
M
G
R
-
S
V
R
-
R
-------
G
-------
D
-----
D
-------
L
F
G
R
N
V
A
M
A
A
R
V
A
A
Q
A
A
G
G
E
I
L
V
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
60.54
33%
-21
- C1 -
4WP9
5
?
A:
[9-135]
------------
V
V
I
L
F
T
D
I
E
E
S
T
A
L
N
E
-
R
I
---
G
D
R
A
W
V
K
L
I
S
S
H
D
K
L
V
S
D
L
V
R
R
Q
S
--
G
---
H
V
V
K
S
Q
G
D
G
F
M
V
A
F
A
-------
R
-------
P
---------
E
Q
-------
A
V
R
C
G
I
E
L
Q
----------------------------------
R
A
L
R
R
N
A------------------------------------------------------------------------------------------------------
E
---------
I
R
V
R
I
G
I
H
M
G
R
-
S
V
R
-
R
-------
G
-------
D
-----
D
-------
L
F
G
R
N
V
A
M
A
A
R
V
A
A
Q
A
A
G
G
E
I
L
V
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
60.21
33%
-22
- C1 -
4WPA
2
?
B:
[9-138]
------------
V
V
I
L
F
T
D
I
E
E
S
T
A
L
N
E
-
R
I
---
G
D
R
A
W
V
K
L
I
S
S
H
D
K
L
V
S
D
L
V
R
R
Q
S
--
G
---
H
V
V
K
S
Q
G
D
G
F
M
V
A
F
A
-------
R
-------
P
---------
E
Q
-------
A
V
R
C
G
I
E
L
Q
----------------------------------
R
A
L
R
R
N
A
N-----------------------------------------------------------------------------------------------------
E
---------
I
R
V
R
I
G
I
H
M
G
R
-
S
V
R
-
R
-------
G
-------
D
-----
D
-------
L
F
G
R
N
V
A
M
A
A
R
V
A
A
Q
A
A
G
G
E
I
L
V
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
60.15
33%
-20
- C1 -
4WPA
3
?
A:
[9-138]
------------
V
V
I
L
F
T
D
I
E
E
S
T
A
L
N
E
-
R
I
---
G
D
R
A
W
V
K
L
I
S
S
H
D
K
L
V
S
D
L
V
R
R
Q
S
--
G
---
H
V
V
K
S
Q
G
D
G
F
M
V
A
F
A
-------
R
-------
P
---------
E
Q
-------
A
V
R
C
G
I
E
L
Q
----------------------------------
R
A
L
R
R
N-------------------------------------------------------------------------------------------------------
E
---------
I
R
V
R
I
G
I
H
M
G
R
-
S
V
R
-
R
-------
G
-------
D
-----
D
-------
L
F
G
R
N
V
A
M
A
A
R
V
A
A
Q
A
A
G
G
E
I
L
V
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------