@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0410c: (2016-04-22 )
MAKASETERSGPGTQPADAQTATSATVRPLSTQAVFRPDFGDEDNFPHPTLGPDTEPQDRMATTSRVRPPVRRLGGGLVEIPRAPDIDPLEALMTNPVVPESKRFCWNCGRPVGRSDSETKGASEGWCPYCGSPYSFLPQLNPGDIVAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAERQFLAEVVHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLKRSKGQKLPVAEAIAYLLEILPALSYLHSIGLVYNDLKPENIMLTEEQLKLIDLGAVSRINSFGYLYGTPGFQAPEIVRTGPTVATDIYTVGRTLAALTLDLPTRNGRYVDGLPEDDPVLKTYDSYGRLLRRAIDPDPRQRFTTAEEMSAQLTGVLREVVAQDTGVPRPGLSTIFSPSRSTFGVDLLVAHTDVYLDGQVHAEKLTANEIVTALSVPLVDPTDVAASVLQATVLSQPVQTLDSLRAARHGALDADGVDFSESVELPLMEVRALLDLGDVAKATRKLDDLAERVGWRWRLVWYRAVAELLTGDYDSATKHFTEVLDTFPGELAPKLALAATAELAGNTDEHKFYQTVWSTNDGVISAAFGLARARSAEGDRVGAVRTLDEVPPTSRHFTTARLTSAVTLLSGRSTSEVTEEQIRDAARRVEALPPTEPRVLQIRALVLGGALDWLKDNKASTNHILGFPFTSHGLRLGVEASLRSLARVAPTQRHRYTLVDMANKVRPTSTF
Atome Classification :
(24 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.........160.......170.-.....-------.180.....--.-----.190.......200-.--.......210.......220.......230.......240..---..----.---.--.--..250--.......260.......270.......280..-..----.-----..290...-----...---.300-.---..----....---..310.....-..-320--.--..-......330.......340.----......-----350---.----.----.----------.-----.----.-.--.360.------.---------------.....370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAKASETERSGPGTQPADAQTATS
A
T
V
RPLST
Q
A
V
FRPDFGDEDNFPHPTLGPDTEP
Q
D
RMATTSRVR
P
P
V
R
R
LGG
G
L
V
EIPRAPDI
D
P
L
E
A
L
MTNPVVPESK
R
F
CWNCGRPVGRSDSETKGASEGWCPYCG
S
P
Y
S
FLPQLNPGDIVAG
Q
--
Y
E
V
K
G
C
I
AHGG
L
G
W
I
Y
L
A
L
DRNV-NGR
P
V
-------
V
L
K
G
L
VHSG--D-----
A
E
A
Q
A
M
A
M
A
E
R
Q
F
--
L
--
A
E
VV
H
P
S
I
V
Q
I
F
N
F
V
E
H
TDRHGD
P
V
G
Y
I
V
M
E
YVGG
Q
S
L
--
K
R---SK----G---Q--K--L
P
V
A
E
--
A
I
A
Y
L
L
E
I
L
P
A
L
S
Y
L
H
S
I
G
L
V
YNDLKPE
N
I
M
L-
T
E
----
E
-----
Q
L
K
L
I
D
L
G
-----
A
V
S
---
R
I---N---SF----
G
Y
L
Y---GTPGFQAP
E
I
-VR-T----G--P
T
-
V
A
T
D
I
Y
T
V
GR
T
L
A
A
L
T
L
DLP----TRNGRY-----VD----G----L----P----------E-----D----D-
P
--
V
L
K
T
Y
------
D
---------------
S
Y
G
R
L
L
R
R
AIDP
D
P
R
Q
RFT
T
A
E
E
M
S
A
Q
L
T
G
V
L
R
E
V
V
A
QDTGVPRPG
L
S
T
IFSPSRSTF
G
V
D
L
L
V
A
H
T
D
V
Y
LDG
Q
V
H
A
E
KL
T
A
N
E
I
V
T
A
LSVPLV
D
P
T
D
V
A
A
S
V
L
Q
A
T
V
LS
Q
P
V
Q
T
L
D
S
L
R
A
A
RHGALDADGVDFSESVE
L
P
L
M
E
V
R
A
L
LD
L
G
D
V
A
K
A
T
R
K
L
D
D
L
A
E
RVG
W
R
W
R
L
V
W
Y
R
A
V
A
E
L
LTGDY
D
S
A
T
K
H
F
T
E
V
L
D
TF
P
G
E
L
A
P
K
L
A
L
A
A
T
A
E
LAGNT
D
E
H
K
F
Y
Q
T
VWSTND
G
V
I
S
A
A
F
G
LARARSAEGDRVG
A
V
R
T
L
DEVPPTSRH
F
T
T
A
R
L
T
S
A
V
TLLSGRST
S
E
V
T
E
E
Q
I
R
D
A
A
R
R
VEALPPTE
P
R
V
L
Q
I
R
A
L
V
LGG
A
L
D
W
L
KDNKASTN
H
I
L
GFPFTSHG
L
R
L
G
V
E
A
S
L
R
S
L
A
R
VAPTQRH
R
Y
T
L
V
D
M
ANKVRPTSTF
44
HHSearch
96.65
100%
-110
- C2 -
2PZI
7
PKNG_MYCTU
A:
[3-677]
-----------------------------------------------------------------------
H
M
L
G
G
G
L
V
E
I
P
R
A
P
D
I
D
P
L
E
A
L
M
T
N
P
V
V
P
E
S
K
R
F
C
W
N
C
G
R
P
V
G
R
S
-----
G
A
S
E
G
W
C
P
Y
C
G
S
P
Y
S
F
L
P
Q
L
N
P
G
D
I
V
A
G
Q
--
Y
E
V
K
G
C
I
A
H
G
G
L
G
W
I
Y
L
A
L
D
R
N
V
-
N
G
R
P
V
-------
V
L
K
G
L
V
H
S
G
--
D
-----
A
E
A
Q
A
M
A
M
A
E
R
Q
F
--
L
--
A
E
V
V
H
P
S
I
V
Q
I
F
N
F
V
E
H
T
D
R
H
G
D
P
V
G
Y
I
V
M
E
Y
V
G
G
Q
S
L
--
K
--------------
Q
--
K
--
L
P
V
A
E
--
A
I
A
Y
L
L
E
I
L
P
A
L
S
Y
L
H
S
I
G
L
V
Y
N
D
L
K
P
E
N
I
M
L
-
T
E
----
E
-----
Q
L
K
L
I
D
L
G
-----
A
V
S
---
R
I
---
N
---
S
F
----
G
Y
L
Y
---
G
T
P
G
F
Q
A
P
E
I
-
V
R
-
T
----
G
--
P
T
-
V
A
T
D
I
Y
T
V
G
R
T
L
A
A
L
T
L
D
L
P
----
T
R
N
G
R
Y
-----
V
D
----
G
----
L
----
P
----------
E
-----
D
----
D
-
P
--
V
L
K
T
Y
------
D
---------------
S
Y
G
R
L
L
R
R
A
I
D
P
D
P
R
Q
R
F
T
T
A
E
E
M
S
A
Q
L
T
G
V
L
R
E
V
V
A
Q
D
T
G
V
P
R
P
G
L
S
T
I
F
S
P
S
R
S
T
F
G
V
D
L
L
V
A
H
T
D
V
Y
L
D
G
Q
V
H
A
E
K
L
T
A
N
E
I
V
T
A
L
S
V
P
L
V
D
P
T
D
V
A
A
S
V
L
Q
A
T
V
L
S
Q
P
V
Q
T
L
D
S
L
R
A
A
R
H
G
-------
D
F
S
E
S
V
E
L
P
L
M
E
V
R
A
L
L
D
L
G
D
V
A
K
A
T
R
K
L
D
D
L
A
E
R
V
G
W
R
W
R
L
V
W
Y
R
A
V
A
E
L
L
T
G
D
Y
D
S
A
T
K
H
F
T
E
V
L
D
T
F
P
G
E
L
A
P
K
L
A
L
A
A
T
A
E
L
A
G
N
T
D
E
H
K
F
Y
Q
T
V
W
S
T
N
D
G
V
I
S
A
A
F
G
L
A
R
A
R
S
A
E
G
D
R
V
G
A
V
R
T
L
D
E
V
P
P
T
S
R
H
F
T
T
A
R
L
T
S
A
V
T
L
L
-------
V
T
E
E
Q
I
R
D
A
A
R
R
V
E
A
L
P
P
T
E
P
R
V
L
Q
I
R
A
L
V
L
G
G
A
L
D
W
L
K
D
N
K
A
S
T
N
H
I
L
G
F
P
F
T
S
H
G
L
R
L
G
V
E
A
S
L
R
S
L
A
R
V
A
P
T
Q
R
H
R
Y
T
L
V
D
M
A
N
K
V
R
P
----
66
Fugue
96.04
99%
-109
- C2 -
2PZI
7
PKNG_MYCTU
A:
[1-677]
---------------------------------------------------------------------
G
S
H
M
L
G
G
G
L
V
E
I
P
R
A
P
D
I
D
P
L
E
A
L
M
T
N
P
V
V
P
E
S
K
R
F
C
W
N
C
G
R
P
V
G
R
S
-----
G
A
S
E
G
W
C
P
Y
C
G
S
P
Y
S
F
L
P
Q
L
N
P
G
D
I
V
A
G
Q
--
Y
E
V
K
G
C
I
A
H
G
G
L
G
W
I
Y
L
A
L
D
R
N
V
-
N
G
R
P
V
-------
V
L
K
G
L
V
H
S
G
--
D
-----
A
E
A
Q
A
M
A
M
A
E
R
Q
F
--
L
--
A
E
V
V
H
P
S
I
V
Q
I
F
N
F
V
E
H
T
D
R
H
G
D
P
V
G
Y
I
V
M
E
Y
V
G
G
Q
S
L
--
K
--------------
Q
--
K
--
L
P
V
A
E
--
A
I
A
Y
L
L
E
I
L
P
A
L
S
Y
L
H
S
I
G
L
V
Y
N
D
L
K
P
E
N
I
M
L
-
T
E
----
E
-----
Q
L
K
L
I
D
L
G
-----
A
V
S
---
R
I
---
N
---
S
F
----
G
Y
L
Y
---
G
T
P
G
F
Q
A
P
E
I
-
V
R
-
T
----
G
--
P
T
-
V
A
T
D
I
Y
T
V
G
R
T
L
A
A
L
T
L
D
L
P
----
T
R
N
G
R
Y
-----
V
D
----
G
----
L
----
P
----------
E
-----
D
----
D
-
P
--
V
L
K
T
Y
------
D
---------------
S
Y
G
R
L
L
R
R
A
I
D
P
D
P
R
Q
R
F
T
T
A
E
E
M
S
A
Q
L
T
G
V
L
R
E
V
V
A
Q
D
T
G
V
P
R
P
G
L
S
T
I
F
S
P
S
R
S
T
F
G
V
D
L
L
V
A
H
T
D
V
Y
L
D
G
Q
V
H
A
E
K
L
T
A
N
E
I
V
T
A
L
S
V
P
L
V
D
P
T
D
V
A
A
S
V
L
Q
A
T
V
L
S
Q
P
V
Q
T
L
D
S
L
R
A
A
R
H
G
-------
D
F
S
E
S
V
E
L
P
L
M
E
V
R
A
L
L
D
L
G
D
V
A
K
A
T
R
K
L
D
D
L
A
E
R
V
G
W
R
W
R
L
V
W
Y
R
A
V
A
E
L
L
T
G
D
Y
D
S
A
T
K
H
F
T
E
V
L
D
T
F
P
G
E
L
A
P
K
L
A
L
A
A
T
A
E
L
A
G
N
T
D
E
H
K
F
Y
Q
T
V
W
S
T
N
D
G
V
I
S
A
A
F
G
L
A
R
A
R
S
A
E
G
D
R
V
G
A
V
R
T
L
D
E
V
P
P
T
S
R
H
F
T
T
A
R
L
T
S
A
V
T
L
L
V
-------
T
E
E
Q
I
R
D
A
A
R
R
V
E
A
L
P
P
T
E
P
R
V
L
Q
I
R
A
L
V
L
G
G
A
L
D
W
L
K
D
N
K
A
S
T
N
H
I
L
G
F
P
F
T
S
H
G
L
R
L
G
V
E
A
S
L
R
S
L
A
R
V
A
P
T
Q
R
H
R
Y
T
L
V
D
M
A
N
K
V
R
P
----
1
PsiBlast_PDB
95.01
100%
-110
- C2 -
2PZI
7
PKNG_MYCTU
A:
[5-677]
-------------------------------------------------------------------------
L
G
G
G
L
V
E
I
P
R
A
P
D
I
D
P
L
E
A
L
M
T
N
P
V
V
P
E
S
K
R
F
C
W
N
C
G
R
P
V
G
R
S
-----
G
A
S
E
G
W
C
P
Y
C
G
S
P
Y
S
F
L
P
Q
L
N
P
G
D
I
V
A
G
Q
--
Y
E
V
K
G
C
I
A
H
G
G
L
G
W
I
Y
L
A
L
D
R
N
V
-
N
G
R
P
V
-------
V
L
K
G
L
V
H
S
G
--
D
-----
A
E
A
Q
A
M
A
M
A
E
R
Q
F
--
L
--
A
E
V
V
H
P
S
I
V
Q
I
F
N
F
V
E
H
T
D
R
H
G
D
P
V
G
Y
I
V
M
E
Y
V
G
G
Q
S
L
--
K
--------------
Q
--
K
--
L
P
V
A
E
--
A
I
A
Y
L
L
E
I
L
P
A
L
S
Y
L
H
S
I
G
L
V
Y
N
D
L
K
P
E
N
I
M
L
-
T
E
----
E
-----
Q
L
K
L
I
D
L
G
-----
A
V
S
---
R
I
---
N
---
S
F
----
G
Y
L
Y
---
G
T
P
G
F
Q
A
P
E
I
-
V
R
-
T
----
G
--
P
T
-
V
A
T
D
I
Y
T
V
G
R
T
L
A
A
L
T
L
D
L
P
----
T
R
N
G
R
Y
-----
V
D
----
G
----
L
----
P
----------
E
-----
D
----
D
-
P
--
V
L
K
T
Y
------
D
---------------
S
Y
G
R
L
L
R
R
A
I
D
P
D
P
R
Q
R
F
T
T
A
E
E
M
S
A
Q
L
T
G
V
L
R
E
V
V
A
Q
D
T
G
V
P
R
P
G
L
S
T
I
F
S
P
S
R
S
T
F
G
V
D
L
L
V
A
H
T
D
V
Y
L
D
G
Q
V
H
A
E
K
L
T
A
N
E
I
V
T
A
L
S
V
P
L
V
D
P
T
D
V
A
A
S
V
L
Q
A
T
V
L
S
Q
P
V
Q
T
L
D
S
L
R
A
A
R
H
G
-------
D
F
S
E
S
V
E
L
P
L
M
E
V
R
A
L
L
D
L
G
D
V
A
K
A
T
R
K
L
D
D
L
A
E
R
V
G
W
R
W
R
L
V
W
Y
R
A
V
A
E
L
L
T
G
D
Y
D
S
A
T
K
H
F
T
E
V
L
D
T
F
P
G
E
L
A
P
K
L
A
L
A
A
T
A
E
L
A
G
N
T
D
E
H
K
F
Y
Q
T
V
W
S
T
N
D
G
V
I
S
A
A
F
G
L
A
R
A
R
S
A
E
G
D
R
V
G
A
V
R
T
L
D
E
V
P
P
T
S
R
H
F
T
T
A
R
L
T
S
A
V
T
L
L
-------
V
T
E
E
Q
I
R
D
A
A
R
R
V
E
A
L
P
P
T
E
P
R
V
L
Q
I
R
A
L
V
L
G
G
A
L
D
W
L
K
D
N
K
A
S
T
N
H
I
L
G
F
P
F
T
S
H
G
L
R
L
G
V
E
A
S
L
R
S
L
A
R
V
A
P
T
Q
R
H
R
Y
T
L
V
D
M
A
N
K
V
R
P
----
3
PsiBlast_PDB
72.17
100%
-114
- C2 -
4Y12
4
PKNG_MYCTU
A:
[53-374]
----------------------------------------------------------------------------------
R
A
P
D
I
D
P
L
E
A
L
M
T
N
P
V
V
P
E
S
K
R
F
C
W
N
C
G
R
P
V
G
R
S
D
S
E
T
K
G
A
S
E
G
W
C
P
Y
C
G
S
P
Y
S
F
L
P
Q
L
N
P
G
D
I
V
A
G
Q
--
Y
E
V
K
G
C
I
A
H
G
G
L
G
W
I
Y
L
A
L
D
R
N
V
-
N
G
R
P
V
-------
V
L
K
G
L
V
H
S
G
--
D
-----
A
E
A
Q
A
M
A
M
A
E
R
Q
F
--
L
--
A
E
V
V
H
P
S
I
V
Q
I
F
N
F
V
E
H
T
D
R
H
G
D
P
V
G
Y
I
V
M
E
Y
V
G
G
Q
S
L
--
K
R
---
S
K
----
G
---
Q
--
K
--
L
P
V
A
E
--
A
I
A
Y
L
L
E
I
L
P
A
L
S
Y
L
H
S
I
G
L
V
Y
N
D
L
K
P
E
N
I
M
L
-
T
E
----
E
-----
Q
L
K
L
I
D
L
G
-----
A
V
S
---
R
I
---
N
---
S
F
----
G
Y
L
Y
---
G
T
P
G
F
Q
A
P
E
I
-
V
R
-
T
----
G
--
P
T
-
V
A
T
D
I
Y
T
V
G
R
T
L
A
A
L
T
L
D
L
P
----
T
R
N
G
R
Y
-----
V
D
----
G
----
L
----
P
----------
E
-----
D
----
D
-
P
--
V
L
K
T
Y
------
D
---------------
S
Y
G
R
L
L
R
R
A
I
D
P
D
P
R
Q
R
F
T
T
A
E
E
M
S
A
Q
L
T
G
V
L
R
E
V
V
A
Q
D
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
71.91
100%
-113
- C2 -
4Y0X
4
PKNG_MYCTU
A:
[53-374]
----------------------------------------------------------------------------------
R
A
P
D
I
D
P
L
E
A
L
M
T
N
P
V
V
P
E
S
K
R
F
C
W
N
C
G
R
P
V
G
R
S
D
S
E
T
K
G
A
S
E
G
W
C
P
Y
C
G
S
P
Y
S
F
L
P
Q
L
N
P
G
D
I
V
A
G
Q
--
Y
E
V
K
G
C
I
A
H
G
G
L
G
W
I
Y
L
A
L
D
R
N
V
-
N
G
R
P
V
-------
V
L
K
G
L
V
H
S
G
--
D
-----
A
E
A
Q
A
M
A
M
A
E
R
Q
F
--
L
--
A
E
V
V
H
P
S
I
V
Q
I
F
N
F
V
E
H
T
D
R
H
G
D
P
V
G
Y
I
V
M
E
Y
V
G
G
Q
S
L
--
K
R
---
S
K
----
G
---
Q
--
K
--
L
P
V
A
E
--
A
I
A
Y
L
L
E
I
L
P
A
L
S
Y
L
H
S
I
G
L
V
Y
N
D
L
K
P
E
N
I
M
L
-
T
E
----
E
-----
Q
L
K
L
I
D
L
G
-----
A
V
S
---
R
I
---
N
---
S
F
----
G
Y
L
Y
---
G
T
P
G
F
Q
A
P
E
I
-
V
R
-
T
----
G
--
P
T
-
V
A
T
D
I
Y
T
V
G
R
T
L
A
A
L
T
L
D
L
P
----
T
R
N
G
R
Y
-----
V
D
----
G
----
L
----
P
----------
E
-----
D
----
D
-
P
--
V
L
K
T
Y
------
D
---------------
S
Y
G
R
L
L
R
R
A
I
D
P
D
P
R
Q
R
F
T
T
A
E
E
M
S
A
Q
L
T
G
V
L
R
E
V
V
A
Q
D
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
71.70
99%
-113
- C2 -
4Y0X
4
PKNG_MYCTU
A:
[53-373]
----------------------------------------------------------------------------------
R
A
P
D
I
D
P
L
E
A
L
M
T
N
P
V
V
P
E
S
K
R
F
C
W
N
C
G
R
P
V
G
R
S
D
S
E
T
K
G
A
S
E
G
W
C
P
Y
C
G
S
P
Y
S
F
L
P
Q
L
N
P
G
D
I
V
A
G
Q
--
Y
E
V
K
G
C
I
A
H
G
G
L
G
W
I
Y
L
A
L
D
R
N
V
-
N
G
R
P
V
-------
V
L
K
G
L
V
H
S
G
--
D
-----
A
E
A
Q
A
M
A
M
A
E
R
Q
F
--
L
--
A
E
V
V
H
P
S
I
V
Q
I
F
N
F
V
E
H
T
D
R
H
G
D
P
V
G
Y
I
V
M
E
Y
V
G
G
Q
S
L
--
K
R
---
S
K
----
G
---
Q
--
K
--
L
P
V
A
E
--
A
I
A
Y
L
L
E
I
L
P
A
L
S
Y
L
H
S
I
G
L
V
Y
N
D
L
K
P
E
N
I
M
L
-
T
E
----
E
-----
Q
L
K
L
I
D
L
G
-----
A
V
S
---
R
I
---
N
---
S
F
----
G
Y
L
Y
---
G
T
P
G
F
Q
A
P
E
I
-
V
R
-
T
----
G
--
P
T
-
V
A
T
D
I
Y
T
V
G
R
T
L
A
A
L
T
L
D
L
P
----
T
R
N
G
R
Y
-----
V
D
----
G
----
L
----
P
----------
E
-----
D
----
D
-
P
--
V
L
K
T
Y
------
D
---------------
S
Y
G
R
L
L
R
R
A
I
D
P
D
P
R
Q
R
F
T
T
A
E
E
M
S
A
Q
L
T
G
V
L
R
E
V
V
A
Q
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
40.39
25%
-99
- C2 -
4EQM
2
?
A:
[6-285]
-----------------------------------------------------------------------------------------------------------------------------------------------
G
K
I
I
N
E
R
--
Y
K
I
V
D
K
L
G
G
G
G
M
S
T
V
Y
L
A
E
D
T
I
L
-
N
I
K
-
V
-------
A
I
K
A
I
F
I
P
P
--
R
-----
E
K
E
E
T
L
K
R
F
E
R
E
V
--
H
N
S
S
Q
L
S
H
Q
N
I
V
S
M
I
D
V
D
E
E
D
D
C
Y
-----
Y
L
V
M
E
Y
I
E
G
P
T
L
--
S
E
Y
I
E
S
H
----
G
------
P
--
L
S
V
D
T
--
A
I
N
F
T
N
Q
I
L
D
G
I
K
H
A
H
D
M
R
I
V
H
R
D
I
K
P
Q
N
I
L
I
D
S
N
----
K
-----
T
L
K
I
F
D
F
G
IAKAL-----------------------------
T
V
Q
Y
F
S
P
E
Q
-
A
K
-
G
----
E
--
A
T
D
E
C
T
D
I
Y
S
I
G
I
V
L
Y
E
M
L
V
G
E
P
----
P
F
N
G
E
T
A
V
S
I
A
I
K
----
H
----
I
----
Q
----------
D
-----
S
----
V
-
P
--
N
V
T
T
D
VRKDIP
Q
---------------
S
L
S
N
V
I
L
R
A
T
E
K
D
K
A
N
R
Y
K
T
I
Q
E
M
K
D
D
L
S
S
V
L
H
E
N
R
A
N
E
D
V
Y
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
HHSearch
39.71
25%
-89
- C2 -
2YAB
4
DAPK2_MOUSE
A:
[9-270]
-------------------------------------------------------------------------------------------------------------------------------------------------
K
V
E
D
F
--
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
--
G
L
E
Y
-------
A
A
K
F
I
K
K
R
Q
--
S
RASRR
G
V
C
R
E
E
I
E
R
E
V
S
I
--
L
--
R
Q
V
L
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
-----
D
V
V
L
I
L
E
L
V
S
G
G
E
L
--
F
D
---
F
L
A
Q
--
K
---
E
--
S
--
L
S
E
E
E
--
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
-
L
D
----
K
NIP
I
P
H
I
K
L
I
D
F
G
-----
L
A
H
---
E
I
---
E
---
D
G
V
E
F
-
K
N
I
F
---
G
T
P
E
F
V
A
P
E
I
-
V
N
-
Y
E---
P
--
L
G
-
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
----
P
F
L
G
D
T
-----
K
Q
----
E
T
L
A
N
I
----
T
A
VSYDF----
D
-----
E
----
E
-
F
--
F
S
Q
T
S
------
E
---------------
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
HHSearch
39.52
19%
-89
- C2 -
4FR4
2
ST32A_HUMAN
A:
[13-280]
--------------------------------------------------------------------------------------------------------------------------------------------------
N
F
D
H
--
F
E
I
L
R
A
I
G
K
G
S
F
G
K
V
C
I
V
Q
K
N
D
T
--
K
K
M
Y
-------
A
M
K
Y
M
N
K
Q
K
C
V
E
-----
R
N
E
V
R
N
V
F
K
E
L
Q
I
--
M
--
Q
G
L
E
H
P
F
L
V
N
L
W
Y
S
F
Q
D
E
E
-----
D
M
F
M
V
V
D
L
L
L
G
G
D
L
--
R
Y
---
H
L
Q
Q
--
N
---
V
--
H
--
F
K
E
E
T
--
V
K
L
F
I
C
E
L
V
M
A
L
D
Y
L
Q
N
Q
R
I
I
H
R
D
M
K
P
D
N
I
L
L
-
D
E
H---
G
-----
H
V
H
I
T
D
F
N
-----
I
A
A
---
M
L
---
P
---
R
E
T
Q
I
-
T
T
M
A
---
G
T
K
P
Y
M
A
P
E
M
-
F
S
-
S
RKGA
G
--
Y
S
-
F
A
V
D
W
W
S
L
G
V
T
A
Y
E
L
L
R
G
R
R
----
P
Y
H
I
R
S
-----
S
T
----
S
S
K
E
-
I
V
H
T
F
E
----------
T
-----
T
----
V
V
T
Y-
P
S
A
W
S
------
Q
---------------
E
M
V
S
L
L
K
K
L
L
E
P
N
P
D
Q
R
F
S
Q
L
S
D
V
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
HHSearch
39.47
25%
-84
- C2 -
4TND
2
GRK5_HUMAN
A:
[181-442]
-------------------------------------------------------------------------------------------------------------------------------------------------
V
T
K
N
T
--
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
A
T
--
G
K
M
Y
-------
A
C
K
R
L
E
K
K
R
I
K
K
-----
R
K
G
E
S
M
A
L
N
E
K
Q
I
--
L
--
E
K
V
N
S
Q
F
V
V
N
L
A
Y
A
Y
E
T
K
D
-----
A
L
C
L
V
L
T
I
M
N
G
G
D
L
--
K
F
---
H
I
Y
NMG
N
---
P
--
G
--
F
E
E
E
R
--
A
L
F
Y
A
A
E
I
L
C
G
L
E
D
L
H
H
E
N
T
V
Y
R
D
L
K
P
E
N
I
L
L
-
D
D
Y---
G
-----
H
I
R
I
S
D
L
G
-----
L
A
V
---
K
I
---
P
---
E
G
D
L
I
-
R
G
R
V
---
G
T
V
G
Y
M
A
P
E
V
-
L
N
-
N
Q---
R
--
Y
G
-
L
S
P
D
Y
W
G
L
G
C
L
I
Y
E
M
I
E
G
Q
S
----
P
F
R
G
R
K
-----
E
K
VK
R
E
E
----
V
----
D
R
R
V
L
------
E
-----
T
----
E
-
E
V
Y
S
H
K
F
S
------
E
---------------
E
A
K
S
I
C
K
M
L
L
T
K
D
A
K
Q
R
L
G
C
Q
E
E
E
A
A
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
39.32
26%
-95
- C2 -
4CZT
9
CIPKN_ARATH
A:
[2-263]
-------------------------------------------------------------------------------------------------------------------------------------------
G
I
H
S
G
R
T
R
V
G
K
--
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
--
R
N
V
E
N
G
D
N
V
-------
A
I
K
V
I
D
K
E
K
--
V
-----
L
K
N
K
M
I
A
Q
I
K
R
E
I
S
T
M
--
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
-----
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
---
S
S
----
N
---
G
--
R
--
L
K
E
D
E
--
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
-
D
A
----
N
G----
A
L
K
V
S
D
F
G
-----
L
S
A
LPQ
Q
V
---
R
---
E
D
----
G
L
L
H
TTC
G
T
P
N
Y
V
A
P
E
V
-
I
N
-
N
----
K
GY
D
G
-
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
---------------------------
L
----
P
F---------
E
-----
D
----
S
-
N
--
L
T
S
L
Y
------
K
K
I
F
K
A
E
F
T
C
P
PWFS
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
Fugue
39.17
18%
-74
- C2 -
4DN5
8
M3K14_HUMAN
A:
[8-351]
------------------------------------------------------------------------------------
S
V
E
E
Y
L
V
H
A
L
Q
G
S
V
S
S
G
Q
A
H
S
L
T
S
L
A
K
T
W
A
A
R
G
S
R
S
R
E
P
S
P
K
T
E
D
N
E
G
V
L
L
T
E
K
L
K
P
V
D
Y
E
Y
R
E
E
V
H
W
A
T
H
Q
L
R
L
G
R
G
S
F
G
E
V
H
R
M
E
D
K
Q
--
T
G
F
Q
C
-------
A
V
K
K
V
R
L
E
V
--
F
-----
R
A
------
E
E
L
M
A
--
C
--
A
G
L
T
S
P
R
I
V
P
L
Y
G
A
V
R
E
-----
G
P
W
V
N
I
F
M
E
L
L
E
G
G
S
L
--
G
Q
---
L
V
----
K
---
E
Q
G
C
--
L
P
E
D
R
--
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
S
R
R
I
L
H
G
D
V
K
A
D
N
V
L
L
-
S
S
----
D
GS---
H
A
A
L
C
D
F
G
-----
H
A
V
---
C
L
---
Q
-----------
I
P
---
G
T
E
T
H
M
A
P
E
V
-
V
L
G
R
----
S
--
C
D
-
A
K
V
D
V
W
S
S
C
C
M
M
L
H
M
L
N
G
C
H
PWTQ
F
F
R
G
P
L
-----
C
L
----
K
----
I
----
A
----------
S
-----
E
----
P
-
P
--
P
V
R
E
I
PPSCA-
P
---------------
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
I
H
R
V
S
-----
A
A
E
L
G
G
K
V
N
R
A
L
Q
Q
V
G
G
L
K
S
P
W
R
G
E
Y
K
E
P
R
H
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
HHSearch
38.15
24%
-87
- C2 -
3UTO
2
UNC22_CAEEL
A:
[154-411]
-------------------------------------------------------------------------------------------------------------------------------------------------
H
V
L
D
H
--
Y
D
I
H
E
E
L
G
T
G
A
F
G
V
V
H
R
V
T
E
R
A
T
--
G
N
N
F
-------
A
A
K
F
V
M
T
P
H
--
E
------
S
D
K
E
T
V
R
K
E
I
Q
T
--
M
--
S
V
L
R
H
P
T
L
V
N
L
H
D
A
F
E
D
D
N
-----
E
M
V
M
I
Y
E
F
M
S
G
G
E
L
--
F
E
---
K
V
A
DE-
H
---
N
--
K
--
M
S
E
D
E
--
A
V
E
Y
M
R
Q
V
C
K
G
L
C
H
M
H
E
N
N
Y
V
H
L
D
L
K
P
E
N
I
M
F
-
T
T
KRS-
N
-----
E
L
K
L
I
D
F
G
-----
L
T
A
---
H
L
---
D
---
P
K
Q
S
V
-
K
V
T
T
---
G
T
A
E
F
A
A
P
E
V
-
A
E
-
G
----
K
P-
V
G
-
Y
Y
T
D
M
W
S
V
G
V
L
S
Y
I
L
L
S
G
L
S
----
P
F
G
G
E
N
-----
D
D
----
E
----
T
----
L
R
N
V
K
S
CDWNM
D
-----
D
----
S
-
A
--
F
S
G
I
S
------
E
---------------
D
G
K
D
F
I
R
K
L
L
L
A
D
P
N
T
R
M
T
I
H
Q
A
L
E
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
HHSearch
37.72
24%
-89
* C2 *
4BKY
2
MELK_HUMAN
A:
[7-259]
-------------------------------------------------------------------------------------------------------------------------------------------------
E
L
L
K
Y
--
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
--
G
E
M
V
-------
A
I
K
I
M
D
K
N
T
--
L
-------
D
L
P
R
I
K
T
E
I
E
A
--
L
--
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
-----
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
--
F
D
---
Y
I
I
S
--
Q
---
D
--
R
--
L
S
E
E
E
--
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
-
D
E
Y---
H
-----
K
L
K
L
I
D
F
G
-----
L
C
A
--------------------------
S
L
A
Y
A
A
P
E
L
-
I
Q
-
G
----
K
---
G
-
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
----
P
F
D
D
D
N
-----
V
M
----
A
----
L
----
Y
K
K
I
M
R
-----
G
-----
K
----
Y
-
D
V
-
P
K
W
L
S
------
P
---------------
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
-
M
K
N
L
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
HHSearch
36.57
21%
-79
- C2 -
3SOA
1
KCC2A_HUMAN
A:
[9-268]
--------------------------------------------------------------------------------------------------------------------------------------------------
F
T
E
E
--
Y
Q
L
F
E
E
L
G
K
G
--
S
V
V
R
R
C
V
K
V
L
A
--
G
Q
E
Y
-------
A
A
M
I
I
N
T
K
K
L-
S
-----
A
R
D
H
Q
K
L
E
R
E
A
R
I
--
C
--
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
-----
H
H
Y
L
I
F
D
L
V
T
G
G
E
L
--
F
E
---
D
I
V
A
--
R
---
E
--
Y
--
Y
S
E
A
D
--
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
N
L
K
P
E
N
L
L
L
-
A
S
KLKG
A
-----
A
V
K
L
A
D
F
G
-----
L
A
I
---
E
V
---
E
---
G
E
Q
Q
A
W
F
G
F
A
---
G
T
P
G
Y
L
S
P
E
V
-
L
R
-
K
D---
P
--
Y
G
-
K
P
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
----
P
F
W
D
E
D
-----
Q
H
----
R
----
L
----
Y
Q
Q
I
K
------
A
GAYDF
P
----
S
-
P
E-
W
D
T
V
T
------
P
---------------
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
T
A
A
E
A
L
K
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
HHSearch
36.05
22%
-78
- C2 -
4LGD
3
STK3_HUMAN
A:
[24-283]
--------------------------------------------------------------------------------------------------------------------------------------------------
P
E
E
V
--
F
D
V
L
E
K
L
G
E
G
S
Y
G
S
V
F
K
A
I
H
K
E
S
--
G
Q
V
V
-------
A
I
K
Q
V
P
V
E
S
----------
D
L
Q
E
I
I
K
E
I
S
I
--
M
--
Q
Q
C
D
S
P
Y
V
V
K
Y
Y
G
S
Y
F
K
N
T
-----
D
L
W
I
V
M
E
Y
C
G
A
G
S
V
--
S
D
---
I
I
R
L
R
-
N
---
K
--
T
--
L
I
E
D
E
--
I
A
T
I
L
K
S
T
L
K
G
L
E
Y
L
H
F
M
R
K
I
H
R
N
I
K
A
G
N
I
L
L
-
N
T
E---
G
-----
H
A
K
L
A
D
F
G
-----
V
A
G
---
Q
L
---
T
---
D
T
MAKR
N
T
V
I
---
G
T
P
F
W
M
A
P
E
V
-
I
Q
-
E
I---
G
--
Y
N
-
C
V
A
D
I
W
S
L
G
I
T
S
I
E
M
A
E
G
K
P
----
P
Y
A
D
I
H
-----
P
M
----
R
A
I
F
M
I
----
P
----------
T
N----
P
PPTF
R
-
K
--
P
E
L
W
S
------
D
---------------
D
F
T
D
F
V
K
K
C
L
V
K
N
P
E
Q
R
A
T
A
T
Q
L
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
HHSearch
35.97
23%
-80
- C2 -
1KOB
1
?
A:
[49-303]
--------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
D
Y
--
Y
D
I
L
E
E
L
G
S
G
A
F
G
V
V
H
R
C
V
E
K
A
T
--
G
R
V
F
-------
V
A
K
F
I
N
T
P
Y
--
P
------
L
D
K
Y
T
V
K
N
E
I
S
I
--
M
--
N
Q
L
H
H
P
K
L
I
N
L
H
D
A
F
E
D
K
Y
-----
E
M
V
L
I
L
E
F
L
S
G
G
E
L
--
F
D
---
R
I
----
A
AED
Y
--
K
--
M
S
E
A
E
--
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
H
S
I
V
H
L
D
I
K
P
E
N
I
M
C
-
E
T
KKA-
S
-----
S
V
K
I
I
D
F
G
-----
L
A
T
---
K
L
---
N
---
P
D
E
I
V
-
K
V
T
T
---
A
T
A
E
F
A
A
P
E
I
-
V
D
-
R
E---
P
--
V
G
-
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
G
L
S
----
P
F
A
G
E
D
-----
D
L
----
E
----
T
----
L
Q
N
V
K
R
C
D
W
E
F
D
-----
E
----
D
-
A
--
F
S
S
V
S
------
P
---------------
E
A
K
D
F
I
K
N
L
L
Q
K
E
P
R
K
R
L
T
V
H
D
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
35.85
26%
-91
- C2 -
4CZU
7
CIPKN_ARATH
A:
[1-266]
------------------------------------------------------------------------------------------------------------------------------------------
P
G
I
H
S
G
R
T
R
V
G
K
--
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
--
R
N
V
E
N
G
D
N
V
-------
A
I
K
V
I
D
K
E
K
--
V
-----
L
K
N
K
M
I
A
Q
I
K
R
E
I
S
T
M
--
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
-----
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
---
S
S
----
N
---
G
--
R
--
L
K
E
D
E
--
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
-
D
A
----
N
G----
A
L
K
V
S
D
F
G
-----
L
S
A
LPQ
Q
V
---
R
---
E
D
----
G
L
L
H
DTC
G
T
P
N
Y
V
A
P
E
V
-
I
N
-
N
----
K
GY
D
G
-
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
---------------------------
L
----
P
F---------
E
-----
D
----
S
-
N
--
L
T
S
L
Y
------
K
K
I
F
K
A
E
F
T
C
P
PWFS
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
HHSearch
35.84
23%
-86
- C2 -
2BDW
-
KCC2D_CAEEL
A:
[5-267]
-----------------------------------------------------------------------------------------------------------------------------------------------
S
T
K
F
S
D
N
--
Y
D
V
K
E
E
L
G
K
G
A
F
S
V
V
R
R
C
V
H
K
T
T
--
G
L
E
F
-------
A
A
K
I
I
N
T
K
K
L-
S
-----
A
R
D
F
Q
K
L
E
R
E
A
R
I
--
C
--
R
K
L
Q
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
S
-----
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
--
F
E
---
D
I
V
A
--
R
---
E
--
F
--
Y
S
E
A
D
--
A
S
H
C
I
Q
Q
I
L
E
S
I
A
Y
C
H
S
N
G
I
V
H
R
N
L
K
P
E
N
L
L
L
-
A
S
KAKG
A
-----
A
V
K
L
A
D
F
G
-----
L
A
I
---
E
V
---
N
---
D
S
E
A
W
-
H
G
F
A
---
G
T
P
G
Y
L
S
P
E
V
-
L
K
-
K
D---
P
--
Y
S
-
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
----
P
F
W
D
E
D
-----
Q
H
----
R
L
Y
A
Q
I
----
K
A
G
A
Y
------
D
Y
----
P
----
S
-
P
E-
W
D
T
V
T
------
P
---------------
E
A
K
S
L
I
D
S
M
L
T
V
N
P
K
K
R
I
T
A
D
Q
A
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
HHSearch
35.63
27%
-82
- C2 -
3I6U
-
CHK2_HUMAN
A:
[216-483]
--------------------------------------------------------------------------------------------------------------------------------------------------
L
R
D
E
--
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
--
C
K
K
V
-------
A
I
R
I
I
S
K
R
K
--
F
AIG------
L
N
V
E
T
E
I
E
I
--
L
--
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
------
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
--
F
D
---
K
V
VG--
N
---
K
--
R
--
L
K
E
A
T
--
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
-
S
S
QEE
D
C
-----
L
I
K
I
T
D
F
G
-----
H
S
K
---
I
L
---
G
------------------
P
T
Y
L
A
P
E
V
-
L
V
-
A
----
G
--
Y
N
-
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
----
P
F
S
E
H
R
-----
T
Q
V---
S
----
L
K
D
Q
I
T
S
GKY------
N
-----
F
----
I
-
P
EV
W
A
E
V
S
------
E
---------------
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
19.87
34%
-78
- C2 -
2YAA
2
DAPK2_MOUSE
B:
[65-205]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
I
--
L
--
R
Q
V
L
H
P
N
I
I
T
L
H
D
V
Y
E
N
---
R
T
D
V
V
--
L
I
L
E
L
V
S
G
G
E
L
--
F
D
---
F
L
----
A
---
Q
--
K
ES
L
S
E
E
E
--
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
-
L
D
----
K
NIP
I
P
H
I
K
L
I
D
F
G
-----
L
A
H
---
E
I
---
E
DG
V
E
F
----
K
N
I
F
---
G
T
P
E
F
V
A
P
E
I
-
V
N
-
Y
----
E
--
P
L
G
L
E
A
D
M
W
S
I
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
17.62
34%
-80
- C2 -
2YAA
2
DAPK2_MOUSE
A:
[65-205]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
I
--
L
--
R
Q
V
L
H
P
N
I
I
T
L
H
D
V
Y
E
N
---
R
T
D
V
V
--
L
I
L
E
L
V
S
G
G
E
L
--
F
D
---
F
L
----
A
---
Q
--
K
ES
L
S
E
E
E
--
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
-
L
D
----
K
NIP
I
P
H
I
K
L
I
D
F
G
-----
L
A
H
---
E
I
---
E
D
G
V
E
F
----
K
N
I
F
---
G
T
P
E
F
V
A
P
E
I
-
V
N
-
Y
----
E
--
P
L
G
L
E
A
D
M
W
S
I
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
15.60
33%
-74
- C2 -
4RLO
7
KS6B1_HUMAN
B:
[7-204]
--------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
--
R
K
V
-
T
G
A
N
T
G
K
I
F
A
M
K
V
L
K
K
----------------------------------
K
H
P
F
I
V
D
L
I
----
Y
A
F
Q
T
G
G
K
L
-
Y
L
I
L
E
Y
L
S
G
G
E
L
--
F
M
---
Q
L
----
E
---
R
--
E
--
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
-
N
H
----
Q
G----
H
V
K
L
T
D
F
G
-----
L
C
K
---
E
S
---
I
-----------------
T
I
E
Y
M
A
P
E
I
L
M
R
-
S
----
G
--
H
N
-
R
A
V
D
W
W
S
L
G
----
A
L
M
Y
D
M
L
----
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
14.79
36%
-81
- C2 -
2J90
3
DAPK3_HUMAN
B:
[79-219]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
N
I
--
L
--
R
E
I
R
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
---
D
V
V
--
L
I
L
E
L
V
S
G
G
E
L
--
F
D
---
F
L
----
A
---
E
--
K
S-
L
T
E
D
E
--
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
-
L
D
----
K
NVP
N
P
R
I
K
L
I
D
F
G
-----
I
A
H
---
K
I
EAG
N
---
E
F
----
K
N
I
F
---
G
T
P
E
F
V
A
P
E
I
-
V
N
-
Y
----
E
--
P
L
G
L
E
A
D
M
W
S
I
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------