@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0859: (2016-04-26 )
MSEEAFIYEAIRTPRGKQKNGSLHEVKPLSLVVGLIDELRKRHPDLDENLISDVILGCVSPVGDQGGDIARAAVLASGMPVTSGGVQLNRFCASGLEAVNTAAQKVRSGWDDLVLAGGVESMSRVPMGSDGGAMGLDPATNYDVMFVPQSIGADLIATIEGFSREDVDAYALRSQQKAAEAWSGGYFAKSVVPVRDQNGLLILDHDEHMRPDTTKEGLAKLKPAFEGLAALGGFDDVALQKYHWVEKINHVHTGGNSSGIVDGAALVMIGSAAAGKLQGLTPRARIVATATSGADPVIMLTGPTPATRKVLDRAGLTVDDIDLFELNEAFASVVLKFQKDLNIPDEKLNVNGGAIAMGHPLGATGAMILGTMVDELERRNARRALITLCIGGGMGVATIIERV
Atome Classification :
(30 SA)
.........10........20---........30........40........50........60........70........80........90........100.......110.......120..----.....130------.---.------------.---------.--------.-------------...---------.140--.....-..----------.150--..--.......160.......170.......180.......190..--.-----.-..-.----200.-.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.--.---.---....350.......360.......370.......380.......390.......400.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSE
E
A
F
I
Y
E
A
I
RTPRGKQKNG---SLHEV
K
P
L
S
L
V
V
G
L
I
D
E
L
R
K
RHPDL
D
E
N
L
I
S
D
V
I
L
G
CVSPVGDQGG
D
I
A
R
A
A
V
L
ASGMPVTSGGV
Q
L
N
R
F
C
A
S
G
L
E
A
V
N
T
A
A
Q
K
V
R
SGWD
D
L
V
LAGG
V
E
S
M
SR----VPMGSD--------G---G------------A---------M--------G-------------LDP---------ATN---Y
D
V
M
F
-
V
P
----------
Q
S----IG--
A
D
L
I
A
T
IEGFSRED
V
D
A
Y
A
L
R
S
Q
Q
K
A
A
E
AWSGG
Y
F
A
KSVVPV--R-----D-QN-
G
----
L
L
-
I
-LDHDEHMRPD
T
T
K
E
G
L
A
K
L
K
P
A
F
E
G
L
A
ALGGF
D
D
V
A
L
Q
K
Y
H
W
V
E
K
I
N
H
V
HTGGNSSGIVDG
A
A
L
V
M
I
GSAAAGKLQGLTPR
A
R
I
V
A
T
ATSGA
D
P
V
I
M
L
TGPT
P
A
T
R
K
V
L
D
RAGLTVDD
I
D
L
F
E
L
N
E
A
F
A
S
V
V
L
K
F
Q
K
DLNI--P---D---EKLNVNG
G
A
I
A
MGHPLGAT
G
A
M
I
L
G
T
M
V
D
E
L
E
R
RNAR
R
A
L
I
T
L
C
IGGG
M
G
V
A
T
I
I
ERV
22
PsiBlast_CBE
98.59
100%
-93
- C7 -
4B3I
5
Y0859_MYCTU
D:
[1-403]
M
S
E
E
A
F
I
Y
E
A
I
R
T
P
R
G
K
Q
K
N
G
---
S
L
H
E
V
K
P
L
S
L
V
V
G
L
I
D
E
L
R
K
R
H
P
D
L
D
E
N
L
I
S
D
V
I
L
G
C
V
S
P
V
G
D
Q
G
G
D
I
A
R
A
A
V
L
A
S
G
M
P
V
T
S
G
G
V
Q
L
N
R
F
C
A
S
G
L
E
A
V
N
T
A
A
Q
K
V
R
S
G
W
D
D
L
V
L
A
G
G
V
E
S
M
S
R
----
V
P
M
G
S
D
--------
G
---
G
------------
A
---------
M
--------
G
-------------
L
D
P
---------
A
T
N
---
Y
D
V
M
F
-
V
P
----------
Q
S
----
I
G
--
A
D
L
I
A
T
I
E
G
F
S
R
E
D
V
D
A
Y
A
L
R
S
Q
Q
K
A
A
E
A
W
S
G
G
Y
F
A
K
S
V
V
P
V
--
R
-----
D
-
Q
N
-
G
----
L
L
-
I
-
L
D
H
D
E
H
M
R
P
D
T
T
K
E
G
L
A
K
L
K
P
A
F
E
G
L
A
A
L
G
G
F
D
D
V
A
L
Q
K
Y
H
W
V
E
K
I
N
H
V
H
T
G
G
N
S
S
G
I
V
D
G
A
A
L
V
M
I
G
S
A
A
A
G
K
L
Q
G
L
T
P
R
A
R
I
V
A
T
A
T
S
G
A
D
P
V
I
M
L
T
G
P
T
P
A
T
R
K
V
L
D
R
A
G
L
T
V
D
D
I
D
L
F
E
L
N
E
A
F
A
S
V
V
L
K
F
Q
K
D
L
N
I
--
P
---
D
---
E
K
L
N
V
N
G
G
A
I
A
M
G
H
P
L
G
A
T
G
A
M
I
L
G
T
M
V
D
E
L
E
R
R
N
A
R
R
A
L
I
T
L
C
I
G
G
G
M
G
V
A
T
I
I
E
R
V
3
PsiBlast_PDB
98.37
100%
-96
- C7 -
4B3J
3
Y0859_MYCTU
C:
[2-403]
-
S
E
E
A
F
I
Y
E
A
I
R
T
P
R
G
K
Q
K
N
G
---
S
L
H
E
V
K
P
L
S
L
V
V
G
L
I
D
E
L
R
K
R
H
P
D
L
D
E
N
L
I
S
D
V
I
L
G
C
V
S
P
V
G
D
Q
G
G
D
I
A
R
A
A
V
L
A
S
G
M
P
V
T
S
G
G
V
Q
L
N
R
F
C
A
S
G
L
E
A
V
N
T
A
A
Q
K
V
R
S
G
W
D
D
L
V
L
A
G
G
V
E
S
M
S
R
----
V
P
M
G
S
D
--------
G
---
G
------------
A
---------
M
--------
G
-------------
L
D
P
---------
A
T
N
---
Y
D
V
M
F
-
V
P
----------
Q
S
----
I
G
--
A
D
L
I
A
T
I
E
G
F
S
R
E
D
V
D
A
Y
A
L
R
S
Q
Q
K
A
A
E
A
W
S
G
G
Y
F
A
K
S
V
V
P
V
--
R
-----
D
-
Q
N
-
G
----
L
L
-
I
-
L
D
H
D
E
H
M
R
P
D
T
T
K
E
G
L
A
K
L
K
P
A
F
E
G
L
A
A
L
G
G
F
D
D
V
A
L
Q
K
Y
H
W
V
E
K
I
N
H
V
H
T
G
G
N
S
S
G
I
V
D
G
A
A
L
V
M
I
G
S
A
A
A
G
K
L
Q
G
L
T
P
R
A
R
I
V
A
T
A
T
S
G
A
D
P
V
I
M
L
T
G
P
T
P
A
T
R
K
V
L
D
R
A
G
L
T
V
D
D
I
D
L
F
E
L
N
E
A
F
A
S
V
V
L
K
F
Q
K
D
L
N
I
--
P
---
D
---
E
K
L
N
V
N
G
G
A
I
A
M
G
H
P
L
G
A
T
G
A
M
I
L
G
T
M
V
D
E
L
E
R
R
N
A
R
R
A
L
I
T
L
C
I
G
G
G
M
G
V
A
T
I
I
E
R
V
21
PsiBlast_CBE
98.24
100%
-96
- C7 -
4B3J
10
Y0859_MYCTU
D:
[1-403]
M
S
E
E
A
F
I
Y
E
A
I
R
T
P
R
G
K
Q
K
N
G
---
S
L
H
E
V
K
P
L
S
L
V
V
G
L
I
D
E
L
R
K
R
H
P
D
L
D
E
N
L
I
S
D
V
I
L
G
C
V
S
P
V
G
D
Q
G
G
D
I
A
R
A
A
V
L
A
S
G
M
P
V
T
S
G
G
V
Q
L
N
R
F
C
A
S
G
L
E
A
V
N
T
A
A
Q
K
V
R
S
G
W
D
D
L
V
L
A
G
G
V
E
S
M
S
R
----
V
P
M
G
S
D
--------
G
---
G
------------
A
---------
M
--------
G
-------------
L
D
P
---------
A
T
N
---
Y
D
V
M
F
-
V
P
----------
Q
S
----
I
G
--
A
D
L
I
A
T
I
E
G
F
S
R
E
D
V
D
A
Y
A
L
R
S
Q
Q
K
A
A
E
A
W
S
G
G
Y
F
A
K
S
V
V
P
V
--
R
-----
D
-
Q
N
-
G
----
L
L
-
I
-
L
D
H
D
E
H
M
R
P
D
T
T
K
E
G
L
A
K
L
K
P
A
F
E
---
A
L
G
G
F
D
D
V
A
L
Q
K
Y
H
W
V
E
K
I
N
H
V
H
T
G
G
N
S
S
G
I
V
D
G
A
A
L
V
M
I
G
S
A
A
A
G
K
L
Q
G
L
T
P
R
A
R
I
V
A
T
A
T
S
G
A
D
P
V
I
M
L
T
G
P
T
P
A
T
R
K
V
L
D
R
A
G
L
T
V
D
D
I
D
L
F
E
L
N
E
A
F
A
S
V
V
L
K
F
Q
K
D
L
N
I
--
P
---
D
---
E
K
L
N
V
N
G
G
A
I
A
M
G
H
P
L
G
A
T
G
A
M
I
L
G
T
M
V
D
E
L
E
R
R
N
A
R
R
A
L
I
T
L
C
I
G
G
G
M
G
V
A
T
I
I
E
R
V
23
PsiBlast_CBE
97.48
100%
-97
- C7 -
4B3H
7
Y0859_MYCTU
D:
[1-403]
M
S
E
E
A
F
I
Y
E
A
I
R
T
P
R
G
K
Q
K
N
G
---
S
L
H
E
V
K
P
L
S
L
V
V
G
L
I
D
E
L
R
K
R
H
P
D
L
D
E
N
L
I
S
D
V
I
L
G
C
V
S
P
V
G
D
Q
G
G
D
I
A
R
A
A
V
L
A
S
G
M
P
V
T
S
G
G
V
Q
L
N
R
F
C
A
S
G
L
E
A
V
N
T
A
A
Q
K
V
R
S
G
W
D
D
L
V
L
A
G
G
V
E
S
M
S
R
----
V
P
M
G
S
D
--------
G
---
G
------------
A
---------
M
--------
G
-------------
L
D
P
---------
A
T
N
---
Y
D
V
M
F
-
V
P
----------
Q
S
----
I
G
--
A
D
L
I
A
T
I
E
G
F
S
R
E
D
V
D
A
Y
A
L
R
S
Q
Q
K
A
A
E
A
W
S
G
G
Y
F
A
K
S
V
V
P
V
--
R
-----
D
-
Q
N
-
G
----
L
L
-
I
-
L
D
H
D
E
H
M
R
P
D
T
T
K
E
G
L
A
K
L
K
P
A
F
--
L
A
A
L
G
G
F
D
D
V
A
L
Q
K
Y
H
W
V
E
K
I
N
H
V
H
T
G
G
N
S
S
G
I
V
D
G
A
A
L
V
M
I
G
S
A
A
A
G
K
L
Q
G
L
T
P
R
A
R
I
V
A
T
A
T
S
G
A
D
P
V
I
M
L
T
G
P
T
P
A
T
R
K
V
L
D
R
A
G
L
T
V
D
D
I
D
L
F
E
L
N
E
A
F
A
S
V
V
L
K
F
Q
K
D
L
N
I
--
P
---
D
---
E
K
L
N
V
N
G
G
A
I
A
M
G
H
P
L
G
A
T
G
A
M
I
L
G
T
M
V
D
E
L
E
R
R
N
A
R
R
A
L
I
T
L
C
I
G
G
G
M
G
V
A
T
I
I
E
R
V
1
PsiBlast_PDB
97.16
100%
-95
- C7 -
4B3H
2
Y0859_MYCTU
C:
[2-403]
-
S
E
E
A
F
I
Y
E
A
I
R
T
P
R
G
K
Q
K
N
G
---
S
L
H
E
V
K
P
L
S
L
V
V
G
L
I
D
E
L
R
K
R
H
P
D
L
D
E
N
L
I
S
D
V
I
L
G
C
V
S
P
V
G
D
Q
G
G
D
I
A
R
A
A
V
L
A
S
G
M
P
V
T
S
G
G
V
Q
L
N
R
F
C
A
S
G
L
E
A
V
N
T
A
A
Q
K
V
R
S
G
W
D
D
L
V
L
A
G
G
V
E
S
M
S
R
----
V
P
M
G
S
D
--------
G
---
G
------------
A
---------
M
--------
G
-------------
L
D
P
---------
A
T
N
---
Y
D
V
M
F
-
V
P
----------
Q
S
----
I
G
--
A
D
L
I
A
T
I
E
G
F
S
R
E
D
V
D
A
Y
A
L
R
S
Q
Q
K
A
A
E
A
W
S
G
G
Y
F
A
K
S
V
V
P
V
--
R
-----
D
-
Q
N
-
G
----
L
L
-
I
-
L
D
H
D
E
H
M
R
P
D
T
T
K
E
G
L
A
K
L
K
P
A
----
A
A
L
G
G
F
D
D
V
A
L
Q
K
Y
H
W
V
E
K
I
N
H
V
H
T
G
G
N
S
S
G
I
V
D
G
A
A
L
V
M
I
G
S
A
A
A
G
K
L
Q
G
L
T
P
R
A
R
I
V
A
T
A
T
S
G
A
D
P
V
I
M
L
T
G
P
T
P
A
T
R
K
V
L
D
R
A
G
L
T
V
D
D
I
D
L
F
E
L
N
E
A
F
A
S
V
V
L
K
F
Q
K
D
L
N
I
--
P
---
D
---
E
K
L
N
V
N
G
G
A
I
A
M
G
H
P
L
G
A
T
G
A
M
I
L
G
T
M
V
D
E
L
E
R
R
N
A
R
R
A
L
I
T
L
C
I
G
G
G
M
G
V
A
T
I
I
E
R
V
2
PsiBlast_PDB
96.67
100%
-94
- C7 -
4B3I
1
Y0859_MYCTU
C:
[2-403]
-
S
E
E
A
F
I
Y
E
A
I
R
T
P
R
G
K
Q
K
N
G
---
S
L
H
E
V
K
P
L
S
L
V
V
G
L
I
D
E
L
R
K
R
H
P
D
L
D
E
N
L
I
S
D
V
I
L
G
C
V
S
P
V
G
D
Q
G
G
D
I
A
R
A
A
V
L
A
S
G
M
P
V
T
S
G
G
V
Q
L
N
R
F
C
A
S
G
L
E
A
V
N
T
A
A
Q
K
V
R
S
G
W
D
D
L
V
L
A
G
G
V
E
S
M
S
R
----
V
P
M
G
S
D
--------
G
---
G
------------
A
---------
M
--------
G
-------------
L
D
P
---------
A
T
N
---
Y
D
V
M
F
-
V
P
----------
Q
S
----
I
G
--
A
D
L
I
A
T
I
E
G
F
S
R
E
D
V
D
A
Y
A
L
R
S
Q
Q
K
A
A
E
A
W
S
G
G
Y
F
A
K
S
V
V
P
V
--
R
-----
D
-
Q
N
-
G
----
L
L
-
I
-
L
D
H
D
E
H
M
R
P
D
T
T
K
E
G
L
A
K
L
K
P
A
F
E
G
L
A
A
L
G
G
F
D
D
V
A
L
Q
K
Y
H
W
V
E
K
I
N
H
V
H
T
G
G
N
S
S
G
I
V
D
G
A
A
L
V
M
I
G
S
A
A
A
G
K
L
Q
G
L
T
P
R
A
R
I
V
A
T
A
T
S
G
A
D
P
V
I
M
L
T
G
P
T
P
A
T
R
K
V
L
D
R
A
G
L
T
V
D
D
I
D
L
F
E
L
N
E
A
F
A
S
V
V
L
K
F
Q
K
D
L
N
I
--
P
---
D
---
E
K
L
N
V
N
G
G
A
I
A
M
G
H
P
L
G
A
T
G
A
M
I
L
G
T
M
V
D
E
L
E
R
R
N
A
R
R
A
L
I
T
L
C
I
G
G
G
M
G
V
A
T
I
I
E
R
V
4
PsiBlast_PDB
89.99
90%
-94
- C7 -
3SVK
-
?
A:
[7-407]
--
E
E
A
F
I
Y
E
A
I
R
T
P
R
G
K
Q
K
N
G
---
S
L
T
E
V
K
P
L
N
L
V
V
G
L
V
D
E
L
R
R
R
Y
P
D
L
D
E
T
L
I
S
D
M
I
L
G
V
V
--------
D
I
A
R
T
A
V
L
A
A
G
L
P
E
T
T
G
G
V
Q
L
N
---
A
S
G
L
E
A
V
N
T
A
A
Q
K
V
R
S
G
W
D
D
L
V
L
A
G
G
V
E
S
M
-----------------------------------------------
W
--------
A
-------------
T
D
P
---------
E
T
N
---
Y
R
I
G
F
-
V
P
----------
Q
G
----
I
G
--
A
D
L
I
A
T
L
E
G
F
S
R
E
D
V
D
A
Y
A
L
R
S
Q
Q
K
A
A
A
A
W
S
G
G
Y
F
A
K
S
V
V
P
V
--
R
-----
D
-
Q
N
-
G
----
L
V
-
I
-
L
D
H
D
E
H
M
R
P
D
T
T
M
E
G
L
A
K
L
K
T
A
F
D
-------------
Q
K
Y
H
W
V
E
K
I
N
H
V
H
T
G
G
N
S
S
G
I
V
D
G
A
A
L
V
L
V
G
S
E
K
A
G
K
S
Q
G
L
T
P
R
A
R
I
V
A
T
A
T
S
------
M
L
T
G
P
T
P
A
T
R
K
V
L
D
R
A
G
L
T
I
D
D
I
D
L
F
E
L
N
E
A
F
A
S
V
V
L
K
F
Q
K
D
L
N
I
--
P
---
D
---
E
K
L
N
V
N
G
G
A
I
A
M
G
H
P
L
G
A
T
G
A
M
I
T
G
T
M
V
D
E
L
E
R
R
N
A
R
R
A
L
I
T
L
C
I
G
G
G
M
G
V
A
T
I
I
E
R
V
101
HHSearch
89.46
90%
-94
- C7 -
3SVK
-
?
A:
[7-406]
--
E
E
A
F
I
Y
E
A
I
R
T
P
R
G
K
Q
K
N
G
---
S
L
T
E
V
K
P
L
N
L
V
V
G
L
V
D
E
L
R
R
R
Y
P
D
L
D
E
T
L
I
S
D
M
I
L
G
V
V
--------
D
I
A
R
T
A
V
L
A
A
G
L
P
E
T
T
G
G
V
Q
L
N
---
A
S
G
L
E
A
V
N
T
A
A
Q
K
V
R
S
G
W
D
D
L
V
L
A
G
G
V
E
S
M
-----------------------------------------------
W
--------
A
-------------
T
D
P
---------
E
T
N
---
Y
R
I
G
F
-
V
P
----------
Q
G
----
I
G
--
A
D
L
I
A
T
L
E
G
F
S
R
E
D
V
D
A
Y
A
L
R
S
Q
Q
K
A
A
A
A
W
S
G
G
Y
F
A
K
S
V
V
P
V
--
R
-----
D
-
Q
N
-
G
----
L
V
-
I
-
L
D
H
D
E
H
M
R
P
D
T
T
M
E
G
L
A
K
L
K
T
A
F
D
-------------
Q
K
Y
H
W
V
E
K
I
N
H
V
H
T
G
G
N
S
S
G
I
V
D
G
A
A
L
V
L
V
G
S
E
K
A
G
K
S
Q
G
L
T
P
R
A
R
I
V
A
T
A
T
S
------
M
L
T
G
P
T
P
A
T
R
K
V
L
D
R
A
G
L
T
I
D
D
I
D
L
F
E
L
N
E
A
F
A
S
V
V
L
K
F
Q
K
D
L
N
I
--
P
---
D
---
E
K
L
N
V
N
G
G
A
I
A
M
G
H
P
L
G
A
T
G
A
M
I
T
G
T
M
V
D
E
L
E
R
R
N
A
R
R
A
L
I
T
L
C
I
G
G
G
M
G
V
A
T
I
I
E
R
-
24
PsiBlast_CBE
89.30
90%
-94
- C7 -
3SVK
1
?
B:
[7-406]
--
E
E
A
F
I
Y
E
A
I
R
T
P
R
G
K
Q
K
N
G
---
S
L
T
E
V
K
P
L
N
L
V
V
G
L
V
D
E
L
R
R
R
Y
P
D
L
D
E
T
L
I
S
D
M
I
L
G
V
V
--------
D
I
A
R
T
A
V
L
A
A
G
L
P
E
T
T
G
G
V
Q
L
N
----
S
G
L
E
A
V
N
T
A
A
Q
K
V
R
S
G
W
D
D
L
V
L
A
G
G
V
E
S
M
-----------------------------------------------
W
--------
A
-------------
T
D
P
---------
E
T
N
---
Y
R
I
G
F
-
V
P
----------
Q
G
----
I
G
--
A
D
L
I
A
T
L
E
G
F
S
R
E
D
V
D
A
Y
A
L
R
S
Q
Q
K
A
A
A
A
W
S
G
G
Y
F
A
K
S
V
V
P
V
--
R
-----
D
-
Q
N
-
G
----
L
V
-
I
-
L
D
H
D
E
H
M
R
P
D
T
T
M
E
G
L
A
K
L
K
T
A
F
D
------------
L
Q
K
Y
H
W
V
E
K
I
N
H
V
H
T
G
G
N
S
S
G
I
V
D
G
A
A
L
V
L
V
G
S
E
K
A
G
K
S
Q
G
L
T
P
R
A
R
I
V
A
T
A
T
S
------
M
L
T
G
P
T
P
A
T
R
K
V
L
D
R
A
G
L
T
I
D
D
I
D
L
F
E
L
N
E
A
F
A
S
V
V
L
K
F
Q
K
D
L
N
I
--
P
---
D
---
E
K
L
N
V
N
G
G
A
I
A
M
G
H
P
L
G
A
T
G
A
M
I
T
G
T
M
V
D
E
L
E
R
R
N
A
R
R
A
L
I
T
L
C
I
G
G
G
M
G
V
A
T
I
I
E
R
-
108
HHSearch
79.29
37%
-73
- C7 -
4W61
-
BKTB_CUPNH
A:
[1-393]
M
T
R
E
V
V
V
V
S
G
V
R
T
A
I
G
T
-
F
G
G
---
S
L
K
D
V
A
P
A
E
L
G
A
L
V
V
R
E
A
L
A
R
A
-
Q
V
S
G
D
D
V
G
H
V
V
F
G
N
V
I
Q
T
E
P
R
D
M
Y
L
G
R
V
A
A
V
N
G
G
V
T
I
N
A
P
A
L
T
V
N
R
L
C
G
S
G
L
Q
A
I
V
S
A
A
Q
T
I
L
L
G
D
T
D
V
A
I
G
G
G
A
E
S
M
S
R
----
A
P
Y
L
A
P
--------
A
---
A
------------
R
---------
W
GARMGDAG
L
-------------
V
D
M
---------
M
L
G
A
L
H
D
P
F
H
R
-
I
H
----------
M
G
----
V
T
--
A
E
N
V
A
K
E
Y
D
I
S
R
A
Q
Q
D
E
A
A
L
E
S
H
R
R
A
S
A
A
I
K
A
G
Y
F
K
D
Q
I
V
P
V
--
V
-----
S
-
K
G
-
R
K
G
--
D
V
-
T
-
F
D
T
D
E
H
V
R
H
D
A
T
I
D
D
M
T
K
L
R
P
V
F
V
K
--------------------
E
N
G
T
V
T
A
G
N
A
S
G
L
N
D
A
A
A
A
V
V
M
M
E
R
A
E
A
E
R
R
G
L
K
P
L
A
R
L
V
S
Y
G
H
A
G
V
D
P
K
A
M
G
I
G
P
V
P
A
T
K
I
A
L
E
R
A
G
L
Q
V
S
D
L
D
V
I
E
A
N
E
A
F
A
A
Q
A
C
A
V
T
K
A
L
G
L
--
D
---
P
---
A
K
V
N
P
N
G
S
G
I
S
L
G
H
P
I
G
A
T
G
A
L
I
T
V
K
A
L
H
E
L
N
R
V
Q
G
R
Y
A
L
V
T
M
C
I
G
G
G
Q
G
I
A
A
I
F
E
R
-
104
HHSearch
78.25
37%
-79
- C7 -
4C2J
8
THIM_HUMAN
A:
[24-415]
-
L
R
G
V
F
V
V
A
A
K
R
T
P
F
G
A
Y
-
G
G
---
L
L
K
D
F
T
A
T
D
L
S
E
F
A
A
K
A
A
L
S
A
G
-
K
V
S
P
E
T
V
D
S
V
I
M
G
N
V
L
Q
S
S
S
D
A
I
Y
L
A
R
H
V
G
L
R
V
G
I
P
K
E
T
P
A
L
T
I
N
R
L
C
G
S
G
F
Q
S
I
V
N
G
C
Q
E
I
C
V
K
E
A
E
V
V
L
C
G
G
T
E
S
M
S
Q
----
A
P
Y
C
V
R
--------
N
---
V
------------
R
FGTKL
G
S
D
I
K
--------
L
-------------
E
D
S
---------
L
W
V
S
LT
D
Q
H
V
Q
-
L
P
----------
M
A
----
M
T
--
A
E
N
L
A
V
K
H
K
I
S
R
E
E
C
D
K
Y
A
L
Q
S
Q
Q
R
W
K
A
A
N
D
A
G
Y
F
N
D
E
M
A
P
I
--
E
-----
V
-
K
-------
K
Q
-
T
-
M
Q
V
D
E
H
A
R
P
Q
T
T
L
E
Q
L
Q
K
L
P
P
V
F
K
K
D
---------------------
G
T
V
T
A
G
N
A
S
G
V
A
D
G
A
G
A
V
I
I
A
S
E
D
A
V
K
K
H
N
F
T
P
L
A
R
I
V
G
Y
F
V
S
G
C
D
P
S
I
M
G
I
G
P
V
P
A
I
S
G
A
L
K
K
A
G
L
S
L
K
D
M
D
L
V
E
V
N
E
A
F
A
P
Q
Y
L
A
V
E
R
S
L
D
L
--
D
---
I
---
S
K
T
N
V
N
G
G
A
I
A
L
G
H
P
L
G
G
S
G
S
R
I
T
A
H
L
V
H
E
L
R
R
R
G
G
K
Y
A
V
G
S
A
C
I
G
G
G
Q
G
I
A
V
I
I
Q
S
-
110
HHSearch
78.14
39%
-74
- C7 -
1WL4
7
THIC_HUMAN
A:
[5-396]
-
S
D
P
V
V
I
V
S
A
A
R
T
I
I
G
S
F
-
N
G
---
A
L
A
A
V
P
V
Q
D
L
G
S
T
V
I
K
E
V
L
K
R
A
-
T
V
A
P
E
D
V
S
E
V
I
F
G
H
V
L
A
A
G
C
-
G
Q
N
P
V
R
Q
A
S
V
G
A
G
I
P
Y
S
V
P
A
W
S
C
Q
M
I
C
G
S
G
L
K
A
V
C
L
A
V
Q
S
I
G
I
G
D
S
S
I
V
V
A
G
G
M
E
N
M
S
K
----
A
P
H
L
A
Y
--------
L
RTG
V
------------
K
I
G
E
------
M
P-------
L
-------------
T
D
S
ILCD-----
G
L
T
---
D
A
F
H
N
-
C
H
----------
M
G
----
I
T
--
A
E
N
V
A
K
K
W
Q
V
S
R
E
D
Q
D
K
V
A
V
L
S
Q
N
R
T
E
N
A
Q
K
A
G
H
F
D
K
E
I
V
P
V
--
L
-----
V
S
T
R
K
G
----
L
I
-
E
-
V
K
T
D
E
F
P
R
H
G
S
N
I
E
A
M
S
K
L
K
P
Y
F
L
T
D
-------------------
G
T
G
T
V
T
P
A
N
A
S
G
I
N
D
G
A
A
A
V
V
L
M
K
K
S
E
A
D
K
R
G
L
T
P
L
A
R
I
V
S
W
S
Q
V
G
V
E
P
S
I
M
G
I
G
P
I
P
A
I
K
Q
A
V
T
K
A
G
W
S
L
E
D
V
D
I
F
E
I
N
E
A
F
A
A
V
S
A
A
I
V
K
E
L
G
L
--
N
---
P
---
E
K
V
N
I
E
G
G
A
I
A
L
G
H
P
L
G
A
S
G
C
R
I
L
V
T
L
L
H
T
L
E
R
M
G
R
S
R
G
V
A
A
L
C
I
G
G
G
M
G
I
A
M
C
V
Q
R
-
111
HHSearch
78.12
40%
-74
- C7 -
3GOA
2
FADA_SALTY
A:
[1-386]
-
M
E
Q
V
V
I
V
D
A
I
R
T
P
M
G
R
S
K
G
G
---
A
F
R
N
V
R
A
E
D
L
S
A
H
L
M
R
S
L
L
A
R
N
P
S
L
T
A
A
T
L
D
D
I
Y
W
G
C
V
Q
Q
T
L
E
Q
G
F
N
I
A
R
N
A
A
L
L
A
E
I
P
H
S
V
P
A
V
T
V
N
R
L
C
G
S
S
M
Q
A
L
H
D
A
A
R
M
I
M
T
G
D
A
Q
V
C
L
V
G
G
V
E
H
M
G
H
----
V
P
M
S
H
G
-----------------------------------
V
--------
D
-------------
F
H
P
---------
G
L
S
---------
G
M
----------
M
G
----
L
T
--
A
E
M
L
S
R
L
H
G
I
S
R
E
M
Q
D
Q
F
A
A
R
S
H
A
R
A
W
A
A
T
Q
S
G
A
F
K
T
E
I
I
P
T
--
G
-----
G
-
H
D
-
A
DG
V
-
L
K
-
Q
-
F
N
Y
D
E
V
I
R
P
E
T
T
V
E
A
L
S
T
L
R
P
A
F
D
P
--------------------
V
S
G
T
V
T
A
G
T
S
S
A
L
S
D
G
A
A
A
M
L
V
M
S
E
S
R
A
R
E
L
G
L
K
P
R
A
R
I
R
S
M
A
V
V
G
C
D
P
S
I
M
G
Y
G
P
V
P
A
S
K
L
A
L
K
K
A
G
L
S
A
S
D
I
D
V
F
E
M
N
E
A
F
A
A
Q
I
L
P
C
I
K
D
L
G
L
--
M
EQI
D
---
E
K
I
N
L
N
G
G
A
I
A
L
G
H
P
L
G
C
S
G
A
R
I
S
T
T
L
I
N
L
M
E
R
K
D
A
Q
F
G
L
A
T
M
C
I
G
L
G
Q
G
I
A
T
V
F
E
R
-
114
HHSearch
78.08
40%
-76
- C7 -
2VU1
5
THIL_ZOORA
A:
[2-391]
-
T
P
S
I
V
I
A
S
A
A
R
T
A
V
G
S
-
F
N
G
---
A
F
A
N
T
P
A
H
E
L
G
A
T
V
I
S
A
V
L
E
R
A
-
G
V
A
A
G
E
V
N
E
V
I
L
G
Q
V
L
P
A
G
E
-
G
Q
N
P
A
R
Q
A
A
M
K
A
G
V
P
Q
E
A
T
A
W
G
M
N
Q
L
C
G
S
G
L
R
A
V
A
L
G
M
Q
Q
I
A
T
G
D
A
S
I
I
V
A
G
G
M
E
S
M
S
M
----
A
P
H
C
A
H
--------
L
---
R
GGV
K
M
G
D
F
KMID
T
---------
M
--------
I
-------------
K
D
----------
G
L
T
---
D
A
F
Y
G
-
Y
H
----------
M
G
----
T
T
--
A
E
N
V
A
K
Q
W
Q
L
S
R
D
E
Q
D
A
F
A
V
A
S
Q
N
K
A
E
A
A
Q
K
D
G
R
F
K
D
E
I
V
P
F
--
I
-----
V
-
K
G
-
R
K
G
--
D
I
-
T
-
V
D
A
D
E
Y
I
R
H
G
A
T
L
D
S
M
A
K
L
R
P
A
F
D
K
E
---------------------
G
T
V
T
A
G
N
A
S
G
L
N
D
G
A
A
A
A
L
L
M
S
E
A
E
A
S
R
R
G
I
Q
P
L
G
R
I
V
S
W
A
T
V
G
V
D
P
K
V
M
G
T
G
P
I
P
A
S
R
K
A
L
E
R
A
G
W
K
I
G
D
L
D
L
V
E
A
N
E
A
F
A
A
Q
A
C
A
V
N
K
D
L
G
W
--
D
---
P
---
S
I
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
A
R
I
L
N
T
L
L
F
E
M
K
R
R
G
A
R
K
G
L
A
T
L
C
I
G
G
G
M
G
V
A
M
C
I
E
S
-
10
PsiBlast_PDB
77.65
37%
-75
- C7 -
3GOA
2
FADA_SALTY
A:
[2-387]
--
E
Q
V
V
I
V
D
A
I
R
T
P
M
G
R
S
K
G
G
---
A
F
R
N
V
R
A
E
D
L
S
A
H
L
M
R
S
L
L
A
R
N
P
S
L
T
A
A
T
L
D
D
I
Y
W
G
C
V
Q
Q
T
L
E
Q
G
F
N
I
A
R
N
A
A
L
L
A
E
I
P
H
S
V
P
A
V
T
V
N
R
L
C
G
S
S
M
Q
A
L
H
D
A
A
R
M
I
M
T
G
D
A
Q
V
C
L
V
G
G
V
E
H
M
G
H
----
V
P
M
S
H
--------------------------
G
---------
V
--------
D
-------------
F
H
P
---------
G
L
S
---------------------
G
M
----
M
G
L
T
A
E
M
L
S
R
L
H
G
I
S
R
E
M
Q
D
Q
F
A
A
R
S
H
A
R
A
W
A
A
T
Q
S
G
A
F
K
T
E
I
I
P
T
G
G
H
-----
D
-
A
D
-
G
----
V
L
-
K
Q
F
N
Y
D
E
V
I
R
P
E
T
T
V
E
A
L
S
T
L
R
P
A
F
D
--------------------
P
V
S
G
T
V
T
A
G
T
S
S
A
L
S
D
G
A
A
A
M
L
V
M
S
E
S
R
A
R
E
L
G
L
K
P
R
A
R
I
R
S
M
A
V
V
G
C
D
P
S
I
M
G
Y
G
P
V
P
A
S
K
L
A
L
K
K
A
G
L
S
A
S
D
I
D
V
F
E
M
N
E
A
F
A
A
Q
I
L
P
C
I
K
D
L
G
L
--
M
EQI
D
---
E
K
I
N
L
N
G
G
A
I
A
L
G
H
P
L
G
C
S
G
A
R
I
S
T
T
L
I
N
L
M
E
R
K
D
A
Q
F
G
L
A
T
M
C
I
G
L
G
Q
G
I
A
T
V
F
E
R
V
37
PsiBlast_CBE
77.30
39%
-76
- C7 -
4XL3
3
?
B:
[2-391]
--
K
E
V
V
I
A
S
A
V
R
T
A
I
G
S
Y
G
K
----
S
L
K
D
V
P
A
V
D
L
G
A
T
A
I
K
E
A
V
K
K
A
G
I
K
P
E
D
-
V
N
E
V
I
L
G
N
V
L
Q
A
G
-
L
G
Q
N
P
A
R
Q
A
S
F
K
A
G
L
P
V
E
I
P
A
M
T
I
N
K
V
C
G
S
G
L
R
T
V
S
L
A
A
Q
I
I
K
A
G
D
A
D
V
I
I
A
G
G
M
E
N
M
S
R
----
A
P
Y
L
A
N
--------
N
---
A
------------
R
---------
W
--------
G
YR-----------
M
G
N
---------
A
K
F
---
V
D
E
M
I
-
T
D
GLWDAFNDYH
M
G
----
I
T
--
A
E
N
I
A
E
R
W
N
I
S
R
E
E
Q
D
E
F
A
L
A
S
Q
K
K
A
E
E
A
I
K
S
G
Q
F
K
D
E
I
V
P
V
VI
K
-----
G
-
R
K
-
G
----
E
T
-
V
-
V
D
T
D
E
H
P
R
F
G
S
T
I
E
G
L
A
K
L
K
P
A
F
---------------------
K
K
D
G
T
V
T
A
G
N
A
S
G
L
N
D
C
A
A
V
L
V
I
M
S
A
E
K
A
K
E
L
G
V
K
P
L
A
K
I
V
S
Y
G
S
A
G
V
D
P
A
I
M
G
Y
G
P
F
Y
A
T
K
A
A
I
E
K
A
G
W
T
V
D
E
L
D
L
I
E
S
N
E
A
F
A
A
Q
S
L
A
V
A
K
D
L
K
F
--
D
---
M
---
N
K
V
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
V
H
A
M
Q
K
R
D
A
K
K
G
L
A
T
L
S
I
G
G
G
Q
G
T
A
I
L
L
E
K
-
19
PsiBlast_PDB
77.27
38%
-82
- C7 -
4DD5
-
THLA_PEPD6
A:
[8-396]
---
E
V
V
I
A
S
A
A
R
T
A
V
G
-
S
F
G
G
---
A
F
K
S
V
S
A
V
E
L
G
V
T
A
A
K
E
A
I
K
R
-
A
N
I
T
P
D
M
I
D
E
S
L
L
G
G
V
L
T
A
G
-
L
G
Q
N
I
A
R
Q
I
A
L
G
A
G
I
P
V
E
K
P
A
M
T
I
N
I
V
C
G
S
G
L
R
S
V
S
M
A
S
Q
L
I
A
L
G
D
A
D
I
M
L
V
G
G
A
E
N
M
S
M
S
P
Y
L
V
P
S
A
R
Y
--------
G
---
A
------------
R
---------
M
--------
G
D
A
A
F
V
DSMIKDGL
S
D
I
---------
F
N
N
---
Y
H
M
----------------
G
----
I
T
--
A
E
N
I
A
E
Q
W
N
I
T
R
E
E
Q
D
E
L
A
L
A
S
Q
N
K
A
E
K
A
Q
A
E
G
K
F
D
E
E
I
V
P
V
V
I
K
---------------
D
T
-
V
-
V
D
K
D
E
Y
I
K
P
G
T
T
M
E
K
L
A
K
L
R
P
A
F
---------------------
K
K
D
G
T
V
T
A
G
N
A
S
G
I
N
D
G
A
A
M
L
V
V
M
A
K
E
K
A
E
E
L
G
I
E
P
L
A
T
I
V
S
Y
G
T
A
G
V
D
P
K
I
M
G
Y
G
P
V
P
A
T
K
K
A
L
E
A
A
N
M
T
I
E
D
I
D
L
V
E
A
N
E
A
F
A
A
Q
S
V
A
V
I
R
D
L
N
I
--
D
---
M
---
N
K
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
C
S
G
A
R
I
L
T
T
L
L
Y
E
M
K
R
R
D
A
K
T
G
L
A
T
L
C
I
G
G
G
M
G
T
T
L
I
V
K
R
-
8
PsiBlast_PDB
77.23
40%
-76
- C7 -
2D3T
1
FADA_PSEFR
C:
[14-390]
-----------
R
T
P
M
G
R
S
K
G
G
---
M
H
R
N
T
R
A
E
D
M
S
A
H
L
I
S
K
V
L
E
R
N
S
K
V
D
P
G
E
V
E
D
V
I
W
G
C
V
N
Q
T
L
E
Q
G
W
N
I
A
R
M
A
S
L
M
T
Q
I
P
H
T
S
A
A
Q
T
V
S
R
L
C
G
S
S
M
S
A
L
H
T
A
A
Q
A
I
M
T
G
N
G
D
V
F
V
V
G
G
V
E
H
M
G
H
----
V
S
M
----------------------------
M
---------
H
--------
G
-------------
V
D
P
---------
N
P
H
---
M
S
L
Y
A
-
A
K
----------
A
S
GMMG
L
T
--
A
E
M
L
G
K
M
H
G
I
S
R
E
Q
Q
D
A
F
A
V
R
S
H
Q
L
A
H
K
A
T
V
E
G
K
F
K
D
E
I
I
P
M
--
Q
GY---
D
-
E
N
-
G
----
F
L
K
I
-
F
D
Y
D
E
T
I
R
P
D
T
T
L
E
S
L
A
A
L
K
P
A
F
N
---
P
K
G
G
-----------------
T
V
T
A
G
T
S
S
Q
I
T
D
G
A
S
C
M
I
V
M
S
A
Q
R
A
K
D
L
G
L
E
P
L
A
V
I
R
S
M
A
V
A
G
V
D
P
A
I
M
G
Y
G
P
V
P
A
T
Q
K
A
L
K
R
A
G
L
N
M
A
D
I
D
F
I
E
L
N
E
A
F
A
A
Q
A
L
P
V
L
K
D
L
K
V
--
L
---
D
KMN
E
K
V
N
L
H
G
G
A
I
A
L
G
H
P
F
G
C
S
G
A
R
I
S
G
T
L
L
N
V
M
K
Q
N
G
G
T
F
G
L
S
T
M
C
I
G
L
G
Q
G
I
A
T
V
F
E
R
V
118
HHSearch
77.21
41%
-77
- C7 -
4DD5
-
THLA_PEPD6
A:
[6-396]
-
M
R
E
V
V
I
A
S
A
A
R
T
A
V
G
S
-
F
G
G
---
A
F
K
S
V
S
A
V
E
L
G
V
T
A
A
K
E
A
I
K
R
A
-
N
I
T
P
D
M
I
D
E
S
L
L
G
G
V
L
T
A
G
L
-
G
Q
N
I
A
R
Q
I
A
L
G
A
G
I
P
V
E
K
P
A
M
T
I
N
I
V
C
G
S
G
L
R
S
V
S
M
A
S
Q
L
I
A
L
G
D
A
D
I
M
L
V
G
G
A
E
N
M
S
M
----
S
P
Y
L
V
P
--------
S
---
A
------------
R
---------
Y
GARM
G
D
A
A
F
-------------
V
D
S
MIKD-----
G
L
S
---
D
I
F
N
N
-
Y
H
----------
M
G
----
I
T
--
A
E
N
I
A
E
Q
W
N
I
T
R
E
E
Q
D
E
L
A
L
A
S
Q
N
K
A
E
K
A
Q
A
E
G
K
F
D
E
E
I
V
P
V
--
V
-----
I
-
K
-------
D
T
-
V
-
V
D
K
D
E
Y
I
K
P
G
T
T
M
E
K
L
A
K
L
R
P
A
F
---------------------
K
K
D
G
T
V
T
A
G
N
A
S
G
I
N
D
G
A
A
M
L
V
V
M
A
K
E
K
A
E
E
L
G
I
E
P
L
A
T
I
V
S
Y
G
T
A
G
V
D
P
K
I
M
G
Y
G
P
V
P
A
T
K
K
A
L
E
A
A
N
M
T
I
E
D
I
D
L
V
E
A
N
E
A
F
A
A
Q
S
V
A
V
I
R
D
L
N
I
--
D
---
M
---
N
K
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
C
S
G
A
R
I
L
T
T
L
L
Y
E
M
K
R
R
D
A
K
T
G
L
A
T
L
C
I
G
G
G
M
G
T
T
L
I
V
K
R
-
113
HHSearch
77.18
43%
-77
- C7 -
1ULQ
-
?
A:
[3-399]
---
E
A
W
I
V
E
A
V
R
T
P
I
G
K
H
-
G
G
---
A
L
A
S
V
R
P
D
D
L
L
A
H
A
L
S
V
L
V
D
R
S
-
G
V
P
K
E
E
V
E
D
V
Y
A
G
C
A
N
Q
A
G
E
D
N
R
N
V
A
R
M
A
L
L
L
A
G
F
P
V
E
V
A
G
C
T
V
N
R
L
C
G
S
G
L
E
A
V
A
Q
A
A
R
A
I
W
A
G
E
G
K
V
Y
I
G
S
G
V
E
S
M
S
R
----
A
P
Y
A
V
P
--------
K
---
P
ERGF
P
T
G
N
----
L
---------
V
--------
M
-------------
Y
D
T
TLGWRFVN
P
K
M
Q
---
A
L
Y
G
T
-
E
S
----------
M
G
----
E
T
--
A
E
N
L
A
E
M
Y
G
I
R
R
E
E
Q
D
R
F
A
L
L
S
H
Q
K
A
V
R
A
W
E
E
G
R
F
Q
D
E
V
V
P
V
--
P
-----
V
-
K
R
-
G
K
E
--
E
I
-
L
-
V
E
Q
D
E
G
P
R
R
D
T
S
L
E
K
L
A
A
L
R
P
V
F
R
E
G
---------------------
G
T
V
T
A
G
N
S
S
P
L
N
D
G
A
A
A
V
L
L
V
S
D
D
Y
A
K
A
H
G
L
R
P
L
A
R
V
R
A
I
A
V
A
G
V
P
P
R
I
M
G
I
G
P
V
P
A
T
R
K
A
L
E
R
A
G
L
S
F
S
D
L
G
L
I
E
L
N
E
A
F
A
A
Q
A
L
A
V
L
R
E
W
S
L
SM
E
---
D
---
Q
R
L
N
P
N
G
G
A
I
A
L
G
H
P
L
G
A
S
G
A
R
I
L
T
T
L
V
H
E
M
R
R
R
K
V
Q
F
G
L
A
T
M
C
I
G
V
G
Q
G
I
A
V
V
V
E
G
-
16
PsiBlast_PDB
76.33
39%
-77
- C7 -
4XL4
7
?
A:
[2-391]
--
K
E
V
V
I
A
S
A
V
R
T
A
I
G
S
Y
G
K
----
S
L
K
D
V
P
A
V
D
L
G
A
T
A
I
K
E
A
V
K
K
A
G
I
K
P
E
D
-
V
N
E
V
I
L
G
N
V
L
Q
A
G
-
L
G
Q
N
P
A
R
Q
A
S
F
K
A
G
L
P
V
E
I
P
A
M
T
I
N
K
V
C
G
S
G
L
R
T
V
S
L
A
A
Q
I
I
K
A
G
D
A
D
V
I
I
A
G
G
M
E
N
M
S
R
----
A
P
Y
L
A
N
--------
N
---
A
------------
R
---------
W
--------
G
YR-----------
M
G
N
---------
A
K
F
---
V
D
E
M
I
-
T
D
GLWDAFNDYH
M
G
----
I
T
--
A
E
N
I
A
E
R
W
N
I
S
R
E
E
Q
D
E
F
A
L
A
S
Q
K
K
A
E
E
A
I
K
S
G
Q
F
K
D
E
I
V
P
V
V
I
K
-----
G
-
R
K
-
G
----
E
T
-
V
-
V
D
T
D
E
H
P
R
F
G
S
T
I
E
G
L
A
K
L
K
P
A
F
---------------------
K
K
D
G
T
V
T
A
G
N
A
S
G
L
N
D
C
A
A
V
L
V
I
M
S
A
E
K
A
K
E
L
G
V
K
P
L
A
K
I
V
S
Y
G
S
A
G
V
D
P
A
I
M
G
Y
G
P
F
Y
A
T
K
A
A
I
E
K
A
G
W
T
V
D
E
L
D
L
I
E
S
N
E
A
F
A
A
Q
S
L
A
V
A
K
D
L
K
F
--
D
---
M
---
N
K
V
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
V
H
A
M
Q
K
R
D
A
K
K
G
L
A
T
L
S
I
G
G
G
Q
G
T
A
I
L
L
E
K
-
36
PsiBlast_CBE
76.17
39%
-78
- C7 -
4XL4
4
?
B:
[2-391]
--
K
E
V
V
I
A
S
A
V
R
T
A
I
G
S
Y
G
K
----
S
L
K
D
V
P
A
V
D
L
G
A
T
A
I
K
E
A
V
K
K
A
G
I
K
P
E
D
-
V
N
E
V
I
L
G
N
V
L
Q
A
G
-
L
G
Q
N
P
A
R
Q
A
S
F
K
A
G
L
P
V
E
I
P
A
M
T
I
N
K
V
C
G
S
G
L
R
T
V
S
L
A
A
Q
I
I
K
A
G
D
A
D
V
I
I
A
G
G
M
E
N
M
S
R
----
A
P
Y
L
A
N
--------
N
---
A
------------
R
---------
W
--------
G
YR-----------
M
G
N
---------
A
K
F
---
V
D
E
M
I
-
T
D
GLWDAFNDYH
M
G
----
I
T
--
A
E
N
I
A
E
R
W
N
I
S
R
E
E
Q
D
E
F
A
L
A
S
Q
K
K
A
E
E
A
I
K
S
G
Q
F
K
D
E
I
V
P
V
VI
K
-----
G
-
R
K
-
G
----
E
T
-
V
-
V
D
T
D
E
H
P
R
F
G
S
T
I
E
G
L
A
K
L
K
P
A
F
---------------------
K
K
D
G
T
V
T
A
G
N
A
S
G
L
N
D
C
A
A
V
L
V
I
M
S
A
E
K
A
K
E
L
G
V
K
P
L
A
K
I
V
S
Y
G
S
A
G
V
D
P
A
I
M
G
Y
G
P
F
Y
A
T
K
A
A
I
E
K
A
G
W
T
V
D
E
L
D
L
I
E
S
N
E
A
F
A
A
Q
S
L
A
V
A
K
D
L
K
F
--
D
---
M
---
N
K
V
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
V
H
A
M
Q
K
R
D
A
K
K
G
L
A
T
L
S
I
G
G
G
Q
G
T
A
I
L
L
E
K
-
13
PsiBlast_PDB
76.02
39%
-75
- C7 -
4WYR
5
THLA_CLOAB
A:
[2-392]
--
K
E
V
V
I
A
S
A
V
R
T
A
I
G
S
Y
G
K
----
S
L
K
D
V
P
A
V
D
L
G
A
T
A
I
K
E
A
V
K
K
A
G
I
K
P
E
D
-
V
N
E
V
I
L
G
N
V
L
Q
A
G
-
L
G
Q
N
P
A
R
Q
A
S
F
K
A
G
L
P
Q
E
I
P
A
M
T
I
N
K
V
C
G
S
G
L
R
T
V
S
L
A
A
Q
I
I
K
A
G
D
A
D
V
I
I
A
G
G
M
E
N
M
S
R
----
A
P
Y
L
A
N
NARWGYRM
G
---
N
------------
A
---------
K
--------
F
-------------
V
D
E
---------
M
I
T
D
GL
W
D
A
F
Y
D
Y
H
----------
M
G
----
I
T
--
A
E
N
I
A
E
R
W
N
I
S
R
E
E
Q
D
E
F
A
L
A
S
Q
K
K
A
E
E
A
I
K
S
G
Q
F
K
D
E
I
V
P
V
V
I
K
-----
G
-
R
K
-
G
----
E
T
-
V
-
V
D
T
D
E
H
P
R
F
G
S
T
I
E
G
L
A
K
L
K
P
A
F
---------------------
K
K
D
G
T
V
T
A
G
N
A
S
G
L
N
D
C
A
A
V
L
V
I
M
S
A
E
K
A
K
E
L
G
V
K
P
L
A
K
I
V
S
Y
G
S
A
G
V
D
P
K
I
M
G
Y
G
P
F
Y
A
T
K
A
A
I
E
K
A
G
W
T
V
D
E
L
D
L
I
E
S
N
E
A
F
A
A
Q
S
L
A
V
A
K
D
L
K
F
--
D
---
M
---
N
K
V
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
V
H
A
M
Q
K
R
D
A
K
K
G
L
A
T
L
C
I
G
G
G
Q
G
T
A
I
L
L
E
K
C
15
PsiBlast_PDB
75.58
39%
-75
- C7 -
4XL3
4
?
A:
[2-391]
--
K
E
V
V
I
A
S
A
V
R
T
A
I
G
S
Y
G
K
----
S
L
K
D
V
P
A
V
D
L
G
A
T
A
I
K
E
A
V
K
K
A
G
I
K
P
E
D
-
V
N
E
V
I
L
G
N
V
L
Q
A
G
-
L
G
Q
N
P
A
R
Q
A
S
F
K
A
G
L
P
V
E
I
P
A
M
T
I
N
K
V
C
G
S
G
L
R
T
V
S
L
A
A
Q
I
I
K
A
G
D
A
D
V
I
I
A
G
G
M
E
N
M
S
R
----
A
P
Y
L
A
N
--------
N
---
A
------------
R
---------
W
--------
G
YR-----------
M
G
N
---------
A
K
F
---
V
D
E
M
I
-
T
D
GLWDAFNDYH
M
G
----
I
T
--
A
E
N
I
A
E
R
W
N
I
S
R
E
E
Q
D
E
F
A
L
A
S
Q
K
K
A
E
E
A
I
K
S
G
Q
F
K
D
E
I
V
P
V
V
I
K
-----
G
-
R
K
-
G
----
E
T
-
V
-
V
D
T
D
E
H
P
R
F
G
S
T
I
E
G
L
A
K
L
K
P
A
F
---------------------
K
K
D
G
T
V
T
A
G
N
A
S
G
L
N
D
C
A
A
V
L
V
I
M
S
A
E
K
A
K
E
L
G
V
K
P
L
A
K
I
V
S
Y
G
S
A
G
V
D
P
A
I
M
G
Y
G
P
F
Y
A
T
K
A
A
I
E
K
A
G
W
T
V
D
E
L
D
L
I
E
S
N
E
A
F
A
A
Q
S
L
A
V
A
K
D
L
K
F
--
D
---
M
---
N
K
V
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
V
H
A
M
Q
K
R
D
A
K
K
G
L
A
T
L
S
I
G
G
G
Q
G
T
A
I
L
L
E
K
-
29
PsiBlast_CBE
75.54
39%
-77
- C7 -
4XL2
7
THLA_CLOAB
B:
[2-392]
--
K
E
V
V
I
A
S
A
V
R
T
A
I
G
S
Y
G
K
----
S
L
K
D
V
P
A
V
D
L
G
A
T
A
I
K
E
A
V
K
K
A
G
I
K
P
E
D
-
V
N
E
V
I
L
G
N
V
L
Q
A
G
-
L
G
Q
N
P
A
R
Q
A
S
F
K
A
G
L
P
V
E
I
P
A
M
T
I
N
K
V
C
G
S
G
L
R
T
V
S
L
A
A
Q
I
I
K
A
G
D
A
D
V
I
I
A
G
G
M
E
N
M
S
R
----
A
P
Y
L
A
N
--------
N
---
A
------------
R
---------
W
--------
G
YR-----------
M
G
N
---------
A
K
F
---
V
D
E
M
I
-
T
D
GLWDAFNDYH
M
G
----
I
T
--
A
E
N
I
A
E
R
W
N
I
S
R
E
E
Q
D
E
F
A
L
A
S
Q
K
K
A
E
E
A
I
K
S
G
Q
F
K
D
E
I
V
P
V
VI
K
-----
G
-
R
K
-
G
----
E
T
-
V
-
V
D
T
D
E
H
P
R
F
G
S
T
I
E
G
L
A
K
L
K
P
A
F
---------------------
K
K
D
G
T
V
T
A
G
N
A
S
G
L
N
D
C
A
A
V
L
V
I
M
S
A
E
K
A
K
E
L
G
V
K
P
L
A
K
I
V
S
Y
G
S
A
---------
G
P
F
Y
A
T
K
A
A
I
E
K
A
G
W
T
V
D
E
L
D
L
I
E
S
N
E
A
F
A
A
Q
S
L
A
V
A
K
D
L
K
F
--
D
---
M
---
N
K
V
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
V
H
A
M
Q
K
R
D
A
K
K
G
L
A
T
L
C
I
G
G
G
Q
G
T
A
I
L
L
E
K
C
30
PsiBlast_CBE
75.26
39%
-75
- C7 -
4XL2
7
THLA_CLOAB
A:
[2-392]
--
K
E
V
V
I
A
S
A
V
R
T
A
I
G
S
Y
G
K
----
S
L
K
D
V
P
A
V
D
L
G
A
T
A
I
K
E
A
V
K
K
A
G
I
K
P
E
D
-
V
N
E
V
I
L
G
N
V
L
Q
A
G
-
L
G
Q
N
P
A
R
Q
A
S
F
K
A
G
L
P
V
E
I
P
A
M
T
I
N
K
V
C
G
S
G
L
R
T
V
S
L
A
A
Q
I
I
K
A
G
D
A
D
V
I
I
A
G
G
M
E
N
M
S
R
----
A
P
Y
L
A
N
--------
N
---
A
------------
R
---------
W
--------
G
YR-----------
M
G
N
---------
A
K
F
---
V
D
E
M
I
-
T
D
G
LWDAFNDYH
M
G
----
I
T
--
A
E
N
I
A
E
R
W
N
I
S
R
E
E
Q
D
E
F
A
L
A
S
Q
K
K
A
E
E
A
I
K
S
G
Q
F
K
D
E
I
V
P
V
V
I
K
-----
G
-
R
K
-
G
----
E
T
-
V
-
V
D
T
D
E
H
P
R
F
G
S
T
I
E
G
L
A
K
L
K
P
A
F
---------------------
K
K
D
G
T
V
T
A
G
N
A
S
G
L
N
D
C
A
A
V
L
V
I
M
S
A
E
K
A
K
E
L
G
V
K
P
L
A
K
I
V
S
Y
G
S
A
---------
G
P
F
Y
A
T
K
A
A
I
E
K
A
G
W
T
V
D
E
L
D
L
I
E
S
N
E
A
F
A
A
Q
S
L
A
V
A
K
D
L
K
F
--
D
---
M
---
N
K
V
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
V
H
A
M
Q
K
R
D
A
K
K
G
L
A
T
L
C
I
G
G
G
Q
G
T
A
I
L
L
E
K
C
35
PsiBlast_CBE
75.06
39%
-73
- C7 -
4WYR
3
THLA_CLOAB
B:
[2-392]
--
K
E
V
V
I
A
S
A
V
R
T
A
I
G
S
Y
G
K
----
S
L
K
D
V
P
A
V
D
L
G
A
T
A
I
K
E
A
V
K
K
A
G
I
K
P
E
D
-
V
N
E
V
I
L
G
N
V
L
Q
A
G
-
L
G
Q
N
P
A
R
Q
A
S
F
K
A
G
L
P
Q
E
I
P
A
M
T
I
N
K
V
C
G
S
G
L
R
T
V
S
L
A
A
Q
I
I
K
A
G
D
A
D
V
I
I
A
G
G
M
E
N
M
S
R
----
A
P
Y
L
A
N
NARWGYRM
G
---
N
------------
A
---------
K
--------
F
-------------
V
D
E
---------
M
I
T
DGL
W
D
A
F
Y
D
Y
H
----------
M
G
----
I
T
--
A
E
N
I
A
E
R
W
N
I
S
R
E
E
Q
D
E
F
A
L
A
S
Q
K
K
A
E
E
A
I
K
S
G
Q
F
K
D
E
I
V
P
V
VI
K
-----
G
-
R
K
-
G
----
E
T
-
V
-
V
D
T
D
E
H
P
R
F
G
S
T
I
E
G
L
A
K
L
K
P
A
F
---------------------
K
K
D
G
T
V
T
A
G
N
A
S
G
L
N
D
C
A
A
V
L
V
I
M
S
A
E
K
A
K
E
L
G
V
K
P
L
A
K
I
V
S
Y
G
S
A
G
V
D
P
K
I
M
G
Y
G
P
F
Y
A
T
K
A
A
I
E
K
A
G
W
T
V
D
E
L
D
L
I
E
S
N
E
A
F
A
A
Q
S
L
A
V
A
K
D
L
K
F
--
D
---
M
---
N
K
V
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
V
H
A
M
Q
K
R
D
A
K
K
G
L
A
T
L
C
I
G
G
G
Q
G
T
A
I
L
L
E
K
C
34
PsiBlast_CBE
72.68
38%
-73
- C7 -
4UBV
9
?
A:
[14-399]
------
I
V
E
A
T
R
S
P
I
G
K
-
R
N
G
WLS
G
L
H
A
T
E
L
L
G
A
V
Q
K
A
V
V
D
K
A
G
I
Q
S
G
L
H
A
G
D
V
E
Q
V
I
G
G
C
V
T
Q
F
G
E
Q
S
N
N
I
S
R
V
A
W
L
T
A
G
L
P
E
H
V
G
A
T
T
V
D
C
Q
-
G
S
G
Q
Q
A
N
H
L
I
A
G
L
I
A
A
G
A
I
D
V
G
I
A
C
G
I
E
A
M
S
R
----
V
G
L
G
A
N
--------
A
---
G
------------
P
D--------
R
--------
S
-------------
L
I
R
---------
A
Q
S
---
W
D
I
D
L
-
P
N
----------
Q
F
----
E
A
--
A
E
R
I
A
K
R
R
G
I
T
R
E
D
V
D
V
F
G
L
E
S
Q
R
R
A
Q
R
A
W
A
E
G
R
F
D
R
E
I
S
P
I
--
Q
A
P
V
L
D
E
-
Q
N
-
Q
PTGE
R
R
-
L
-
V
F
R
D
Q
G
L
R
-
E
T
T
M
A
G
L
G
E
L
K
P
V
L
E
G
----------------------
G
I
H
T
A
G
T
S
S
Q
I
S
D
G
A
A
A
V
L
W
M
D
E
A
V
A
R
A
H
G
L
T
P
R
A
R
I
V
A
Q
A
L
V
G
A
E
P
Y
Y
H
L
D
G
P
V
Q
S
T
A
K
V
L
E
K
A
G
M
K
I
G
D
I
D
I
V
E
I
N
E
A
F
A
S
V
V
L
S
W
A
R
-
V
H
E
--
P
---
D
M--
D
R
V
N
V
N
G
G
A
I
A
L
G
H
P
V
G
C
T
G
S
R
L
I
T
T
A
L
H
E
L
E
R
T
D
Q
S
L
A
L
I
T
M
C
A
G
G
A
L
S
T
G
T
I
I
E
R
I
12
PsiBlast_PDB
72.45
38%
-73
- C7 -
4UBW
21
?
A:
[14-399]
------
I
V
E
A
T
R
S
P
I
G
K
-
R
N
G
WLS
G
L
H
A
T
E
L
L
G
A
V
Q
K
A
V
V
D
K
A
G
I
Q
S
G
L
H
A
G
D
V
E
Q
V
I
G
G
C
V
T
Q
F
G
E
Q
S
N
N
I
S
R
V
A
W
L
T
A
G
L
P
E
H
V
G
A
T
T
V
D
C
Q
C
G
S
G
Q
Q
A
N
H
L
I
A
G
L
I
A
A
G
A
I
D
V
G
I
A
C
G
I
E
A
M
S
R
----
V
G
L
G
A
N
--------
A
---
G
------------
P
D--------
R
------------------------------------
S
---
W
D
I
D
L
-
P
N
----------
Q
F
----
E
A
--
A
E
R
I
A
K
R
R
G
I
T
R
E
D
V
D
V
F
G
L
E
S
Q
R
R
A
Q
R
A
W
A
E
G
R
F
D
R
E
I
S
P
I
--
Q
A
P
V
L
D
E
-
Q
N
-
Q
PTGE
R
R
-
L
-
V
F
R
D
Q
G
L
R
-
E
T
T
M
A
G
L
G
E
L
K
P
V
L
E
G
----------------------
G
I
H
T
A
G
T
S
S
Q
I
S
D
G
A
A
A
V
L
W
M
D
E
A
V
A
R
A
H
G
L
T
P
R
A
R
I
V
A
Q
A
L
V
G
A
E
P
Y
Y
H
L
D
G
P
V
Q
S
T
A
K
V
L
E
K
A
G
M
K
I
G
D
I
D
I
V
E
I
N
E
A
F
A
S
V
V
L
S
W
A
R
-
V
H
E
--
P
---
D
M--
D
R
V
N
V
N
G
G
A
I
A
L
G
H
P
V
G
C
T
G
S
R
L
I
T
T
A
L
H
E
L
E
R
T
D
Q
S
L
A
L
I
T
M
C
A
G
G
A
L
S
T
G
T
I
I
E
R
I
33
PsiBlast_CBE
72.36
38%
-71
- C7 -
4UBV
14
?
B:
[14-399]
------
I
V
E
A
T
R
S
P
I
G
K
-
R
N
G
WLS
G
L
H
A
T
E
L
L
G
A
V
Q
K
A
V
V
D
K
A
G
I
Q
S
G
L
H
A
G
D
V
E
Q
V
I
G
G
C
V
T
Q
F
G
E
Q
S
N
N
I
S
R
V
A
W
L
T
A
G
L
P
E
H
V
G
A
T
T
V
D
C
Q
-
G
S
G
Q
Q
A
N
H
L
I
A
G
L
I
A
A
G
A
I
D
V
G
I
A
C
G
I
E
A
M
S
R
----
V
G
L
G
A
N
--------
A
---
G
------------
P
D--------
R
--------
S
-------------
L
I
R
---------
A
Q
S
---
W
D
I
D
L
-
P
N
----------
Q
F
----
E
A
--
A
E
R
I
A
K
R
R
G
I
T
R
E
D
V
D
V
F
G
L
E
S
Q
R
R
A
Q
R
A
W
A
E
G
R
F
D
R
E
I
S
P
I
--
Q
A
P
V
L
D
E
-
Q
N
-
Q
PTGE
R
R
-
L
-
V
F
R
D
Q
G
L
R
-
E
T
T
M
A
G
L
G
E
L
K
P
V
L
E
G
----------------------
G
I
H
T
A
G
T
S
S
Q
I
S
D
G
A
A
A
V
L
W
M
D
E
A
V
A
R
A
H
G
L
T
P
R
A
R
I
V
A
Q
A
L
V
G
A
E
P
Y
Y
H
L
D
G
P
V
Q
S
T
A
K
V
L
E
K
A
G
M
K
I
G
D
I
D
I
V
E
I
N
E
A
F
A
S
V
V
L
S
W
A
R
-
V
H
E
--
P
---
D
M--
D
R
V
N
V
N
G
G
A
I
A
L
G
H
P
V
G
C
T
G
S
R
L
I
T
T
A
L
H
E
L
E
R
T
D
Q
S
L
A
L
I
T
M
C
A
G
G
A
L
S
T
G
T
I
I
E
R
I