@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0869c: (2016-04-26 )
MTLTALGMPALRSRTNGIADPRVVPTTGPLVDTFGRVANDLRVSLTDRCNLRCSYCMPERGLRWLPGEQLLRPDELARLIHIAVTRLGVTSVRFTGGEPLLAHHLDEVVAATARLRPRPEISLTTNGVGLARRAGALAEAGLDRVNVSLDSIDRAHFAAITRRDRLAHVLAGLAAAKAAGLTPVKVNAVLDPTTGREDVVDLLRFCLERGYQLRVIEQMPLDAGHSWRRNIALSADDVLAALRPHFRLRPDPAPRGSAPAELWLVDAGPNTPRGRFGVIASVSHAFCSTCDRTRLTADGQIRSCLFSTEETDLRRLLRGGADDDAIEAAWRAAMWSKPAGHGINAPDFIQPDRPMSAIGG
Atome Classification :
(20 SA)
------.........10........20........--30........----40.......---.50........----60---....----.-....70........80...---..---------.-.---.90....-.--.-----..100-.--.-.--.-....110..---.--.---.--..120---.-.......--------.130.-.......140.......150.-....-..---------160---.---..-.....170.----------......----180....-...-190..--.....--.200.......210.-.-....-...220.--......230.....-----..240.----------......250....------------..----..260.......270.--------.....-------.280.......290--.......-------..300.......-310.-----......-.320.....-..330...-------....340---.......350.......360-------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------M
T
L
TALG
M
P
A
L
R
SRTNGIADPRVVPTTG
P
--
L
V
D
T
F
G
R
V
A
N
----D
L
R
V
S
LTDR---CN
L
R
CSYCMPE----R----GLRW----L-
P
G
E
QLL
R
P
D
E
L
A
R
L
I
H
I
A
V
---
T
R---------L-G---
V
T
S
V
R
FT-G--G-----E
P
L
L
--
A
--
H
-
H
--
L
-
D
E
V
V
A
A
T
AR---L--R---P--RP
E
-----
I
-
S
L
TTNGV--------
G
L
-
A
R
-
R
A
G
A
L
A
E
AGL
D
R
V
N
V
S
L
DSI
D
-
R
A
H
F
-
A
A
---------
I
T
----
R
---
R
D
-
R
L
A
H
V
L
A
G
L
----------
A
A
A
KAA----GL
T
P
V
K
V
-
N
A
V
-LD-PT--T
G
R
E
D
--
V
V
D
L
L
R
F
C
L
ERG--
Y
-
Q
-
L
R
V
I
-
E
QMPLDA--GH
S
W
R
RNIAL
S
A
D
D
-----
V
L
A
A
LR----------P
H
F
R
LRP-DPAPR------------GS----AP
A
E
L
W
L
V
DAGPNTPR--------GR
F
G
V
-------
I
A
S
V
S
H
A
F
C
STC----DR
T
R
LTA-------DG
Q
I
R
S
C
L
FST
E
-
E
-
T
D
-----
L
R
R
L
L
R-GGAD
D
D
A
I
E
-
A
A
W
R
A
AMW-------SKPAGHG---INAPDFIQPDRPMSAIGG---------------------------------
23
PsiBlast_CBE
94.69
35%
-116
* C4 *
1TV7
3
MOAA_STAA8
B:
[7-310]
---------------------------------------
D
K
L
G
R
P
I
R
----
D
L
R
L
S
V
T
D
R
---
C
N
F
R
C
D
Y
C
M
P
K
----
E
VFGD
D
F
V
F
----
L
-
P
K
N
E
L
L
T
F
D
E
M
A
R
I
A
K
V
-
Y
---
A
E
---------
L
-
G
---
V
K
K
I
R
I
T
-
G
--
G
-----
E
P
L
M
--
R
--
R
-
D
--
L
-
D
V
L
I
A
K
L
N
Q
---
I
--
D
---
G
--
I
E
D
-----
I
-
G
L
T
T
N
G
L
--------
L
L
-
K
K
-
H
G
Q
K
L
Y
D
A
G
L
R
R
I
N
V
S
L
D
A
I
D
-
D
T
L
F
-
Q
S
---------
I
N
----
N
---
R
N
I
K
A
T
T
I
L
E
Q
I
----------
D
Y
A
T
S
I
----
G
L
N
-
V
K
V
-
N
V
V
-
I
Q
-
K
G
--
I
N
D
D
Q
--
I
I
P
M
L
E
Y
F
K
D
K
H
--
I
-
E
-
I
R
F
I
-
E
F
M
D
V
G
N
--
D
N
G
W
D
F
S
K
V
V
T
K
D
E
-----
M
L
T
M
I
E
----------
Q
H
F
E
I
D
P
V
E
P
K
Y
F
------------
G
E
----
V
A
K
Y
Y
R
H
K
D
N
G
V
-------------
Q
F
G
L
-------
I
T
S
V
S
Q
S
F
C
S
T
C
----
T
R
A
R
L
S
S
-------
D
G
K
F
Y
G
C
L
F
A
T
V
-
D
G
F
N
-----
V
K
A
F
I
R
-
S
G
V
T
D
E
E
L
K
-
E
Q
F
K
-
A
L
W
-------
Q
------------------------------------------------------------
2
PsiBlast_PDB
94.63
35%
-117
- C4 -
1TV8
5
MOAA_STAA8
A:
[7-310]
---------------------------------------
D
K
L
G
R
P
I
R
----
D
L
R
L
S
V
T
D
R
---
C
N
F
R
C
D
Y
C
M
P
K
----
E
VFGD
D
F
V
F
----
L
-
P
K
N
E
L
L
T
F
D
E
M
A
R
I
A
K
V
-
Y
---
A
E
---------
L
-
G
---
V
K
K
I
R
I
T
-
G
--
G
-----
E
P
L
M
--
R
--
R
-
D
--
L
-
D
V
L
I
A
K
L
N
Q
---
I
--
D
---
G
--
I
E
D
-----
I
-
G
L
T
T
N
G
L
--------
L
L
-
K
K
-
H
G
Q
K
L
Y
D
A
G
L
R
R
I
N
V
S
L
D
A
I
D
-
D
T
L
F
-
Q
S
---------
I
N
----
N
---
R
N
I
K
A
T
T
I
L
E
Q
I
----------
D
Y
A
T
S
I
----
G
L
N
-
V
K
V
-
N
V
V
-
I
Q
-
K
G
--
I
N
D
D
Q
--
I
I
P
M
L
E
Y
F
K
D
K
H
--
I
-
E
-
I
R
F
I
-
E
F
M
D
V
G
N
--
D
N
G
W
D
F
S
K
V
V
T
K
D
E
-----
M
L
T
M
I
E
----------
Q
H
F
E
I
D
P
V
E
P
K
Y
F
------------
G
E
----
V
A
K
Y
Y
R
H
K
D
N
G
V
-------------
Q
F
G
L
-------
I
T
S
V
S
Q
S
F
C
S
T
C
----
T
R
A
R
L
S
S
-------
D
G
K
F
Y
G
C
L
F
A
T
V
-
D
G
F
N
-----
V
K
A
F
I
R
-
S
G
V
T
D
E
E
L
K
-
E
Q
F
K
-
A
L
W
-------
Q
------------------------------------------------------------
1
PsiBlast_PDB
94.13
35%
-114
- C4 -
1TV7
3
MOAA_STAA8
A:
[7-310]
---------------------------------------
D
K
L
G
R
P
I
R
----
D
L
R
L
S
V
T
D
R
---
C
N
F
R
C
D
Y
C
M
P
K
----
E
VFGD
D
F
V
F
----
L
-
P
K
N
E
L
L
T
F
D
E
M
A
R
I
A
K
V
-
Y
---
A
E
---------
L
-
G
---
V
K
K
I
R
I
T
-
G
--
G
-----
E
P
L
M
--
R
--
R
-
D
--
L
-
D
V
L
I
A
K
L
N
Q
---
I
--
D
---
G
--
I
E
D
-----
I
-
G
L
T
T
N
G
L
--------
L
L
-
K
K
-
H
G
Q
K
L
Y
D
A
G
L
R
R
I
N
V
S
L
D
A
I
D
-
D
T
L
F
-
Q
S
---------
I
N
----
N
---
R
N
I
K
A
T
T
I
L
E
Q
I
----------
D
Y
A
T
S
I
----
G
L
N
-
V
K
V
-
N
V
V
-
I
Q
-
K
G
--
I
N
D
D
Q
--
I
I
P
M
L
E
Y
F
K
D
K
H
--
I
-
E
-
I
R
F
I
-
E
F
M
D
V
G
N
--
D
N
G
W
D
F
S
K
V
V
T
K
D
E
-----
M
L
T
M
I
E
----------
Q
H
F
E
I
D
P
V
E
P
K
Y
F
------------
G
E
----
V
A
K
Y
Y
R
H
K
D
N
G
V
-------------
Q
F
G
L
-------
I
T
S
V
S
Q
S
F
C
S
T
C
----
T
R
A
R
L
S
S
-------
D
G
K
F
Y
G
C
L
F
A
T
V
-
D
G
F
N
-----
V
K
A
F
I
R
-
S
G
V
T
D
E
E
L
K
-
E
Q
F
K
-
A
L
W
-------
Q
------------------------------------------------------------
21
PsiBlast_CBE
93.51
35%
-118
- C4 -
2FB3
5
MOAA_STAA8
B:
[7-310]
---------------------------------------
D
K
L
G
R
P
I
R
----
D
L
R
L
S
V
T
D
R
---
C
N
F
R
C
D
Y
C
M
P
K
----
E
VFGD
D
F
V
F
----
L
-
P
K
N
E
L
L
T
F
D
E
M
A
R
I
A
K
V
-
Y
---
A
E
---------
L
-
G
---
V
K
K
I
R
I
T
-
G
--
G
-----
E
P
L
M
--
R
--
R
-
D
--
L
-
D
V
L
I
A
K
L
N
Q
---
I
--
D
---
G
--
I
E
D
-----
I
-
G
L
T
T
N
G
L
--------
L
L
-
K
K
-
H
G
Q
K
L
Y
D
A
G
L
R
R
I
N
V
S
L
D
A
I
D
-
D
T
L
F
-
Q
S
---------
I
N
----
N
---
R
N
I
K
A
T
T
I
L
E
Q
I
----------
D
Y
A
T
S
I
----
G
L
N
-
V
K
V
-
N
V
V
-
I
Q
-
K
G
--
I
N
D
D
Q
--
I
I
P
M
L
E
Y
F
K
D
K
H
--
I
-
E
-
I
R
F
I
-
E
F
M
D
V
G
N
--
D
N
G
W
D
F
S
K
V
V
T
K
D
E
-----
M
L
T
M
I
E
----------
Q
H
F
E
I
D
P
V
E
P
K
Y
F
------------
G
E
----
V
A
K
Y
Y
R
H
K
D
N
G
V
-------------
Q
F
G
L
-------
I
T
S
V
S
Q
S
F
C
S
T
C
----
T
R
A
R
L
S
S
-------
D
G
K
F
Y
G
C
L
F
A
T
V
-
D
G
F
N
-----
V
K
A
F
I
R
-
S
G
V
T
D
E
E
L
K
-
E
Q
F
K
-
A
L
W
-------
Q
------------------------------------------------------------
22
PsiBlast_CBE
93.49
35%
-117
- C4 -
1TV8
4
MOAA_STAA8
B:
[7-310]
---------------------------------------
D
K
L
G
R
P
I
R
----
D
L
R
L
S
V
T
D
R
---
C
N
F
R
C
D
Y
C
M
P
K
----
E
VFGD
D
F
V
F
----
L
-
P
K
N
E
L
L
T
F
D
E
M
A
R
I
A
K
V
-
Y
---
A
E
---------
L
-
G
---
V
K
K
I
R
I
T
-
G
--
G
-----
E
P
L
M
--
R
--
R
-
D
--
L
-
D
V
L
I
A
K
L
N
Q
---
I
--
D
---
G
--
I
E
D
-----
I
-
G
L
T
T
N
G
L
--------
L
L
-
K
K
-
H
G
Q
K
L
Y
D
A
G
L
R
R
I
N
V
S
L
D
A
I
D
-
D
T
L
F
-
Q
S
---------
I
N
----
N
---
R
N
I
K
A
T
T
I
L
E
Q
I
----------
D
Y
A
T
S
I
----
G
L
N
-
V
K
V
-
N
V
V
-
I
Q
-
K
G
--
I
N
D
D
Q
--
I
I
P
M
L
E
Y
F
K
D
K
H
--
I
-
E
-
I
R
F
I
-
E
F
M
D
V
G
N
--
D
N
G
W
D
F
S
K
V
V
T
K
D
E
-----
M
L
T
M
I
E
----------
Q
H
F
E
I
D
P
V
E
P
K
Y
F
------------
G
E
----
V
A
K
Y
Y
R
H
K
D
N
G
V
-------------
Q
F
G
L
-------
I
T
S
V
S
Q
S
F
C
S
T
C
----
T
R
A
R
L
S
S
-------
D
G
K
F
Y
G
C
L
F
A
T
V
-
D
G
F
N
-----
V
K
A
F
I
R
-
S
G
V
T
D
E
E
L
K
-
E
Q
F
K
-
A
L
W
-------
Q
------------------------------------------------------------
4
PsiBlast_PDB
93.22
34%
-115
- C4 -
2FB2
4
MOAA_STAA8
A:
[7-310]
---------------------------------------
D
K
L
G
R
P
I
R
----
D
L
A
L
S
V
T
D
R
---
C
N
F
R
C
D
Y
C
M
P
K
----
E
VFGD
D
F
V
F
----
L
-
P
K
N
E
L
L
T
F
D
E
M
A
R
I
A
K
V
-
Y
---
A
E
---------
L
-
G
---
V
K
K
I
R
I
T
-
G
--
G
-----
E
P
L
M
--
R
--
R
-
D
--
L
-
D
V
L
I
A
K
L
N
Q
---
I
--
D
---
G
--
I
E
D
-----
I
-
G
L
T
T
N
G
L
--------
L
L
-
K
K
-
H
G
Q
K
L
Y
D
A
G
L
R
R
I
N
V
S
L
D
A
I
D
-
D
T
L
F
-
Q
S
---------
I
N
----
N
---
R
N
I
K
A
T
T
I
L
E
Q
I
----------
D
Y
A
T
S
I
----
G
L
N
-
V
K
V
-
N
V
V
-
I
Q
-
K
G
--
I
N
D
D
Q
--
I
I
P
M
L
E
Y
F
K
D
K
H
--
I
-
E
-
I
R
F
I
-
E
F
M
D
V
G
N
--
D
N
G
W
D
F
S
K
V
V
T
K
D
E
-----
M
L
T
M
I
E
----------
Q
H
F
E
I
D
P
V
E
P
K
Y
F
------------
G
E
----
V
A
K
Y
Y
R
H
K
D
N
G
V
-------------
Q
F
G
L
-------
I
T
S
V
S
Q
S
F
C
S
T
C
----
T
A
A
A
L
S
S
-------
D
G
K
F
Y
G
C
L
F
A
T
V
-
D
G
F
N
-----
V
K
A
F
I
R
-
S
G
V
T
D
E
E
L
K
-
E
Q
F
K
-
A
L
W
-------
Q
------------------------------------------------------------
24
PsiBlast_CBE
93.20
34%
-118
- C4 -
2FB2
4
MOAA_STAA8
B:
[7-310]
---------------------------------------
D
K
L
G
R
P
I
R
----
D
L
A
L
S
V
T
D
R
---
C
N
F
R
C
D
Y
C
M
P
K
----
E
VFGD
D
F
V
F
----
L
-
P
K
N
E
L
L
T
F
D
E
M
A
R
I
A
K
V
-
Y
---
A
E
---------
L
-
G
---
V
K
K
I
R
I
T
-
G
--
G
-----
E
P
L
M
--
R
--
R
-
D
--
L
-
D
V
L
I
A
K
L
N
Q
---
I
--
D
---
G
--
I
E
D
-----
I
-
G
L
T
T
N
G
L
--------
L
L
-
K
K
-
H
G
Q
K
L
Y
D
A
G
L
R
R
I
N
V
S
L
D
A
I
D
-
D
T
L
F
-
Q
S
---------
I
N
----
N
---
R
N
I
K
A
T
T
I
L
E
Q
I
----------
D
Y
A
T
S
I
----
G
L
N
-
V
K
V
-
N
V
V
-
I
Q
-
K
G
--
I
N
D
D
Q
--
I
I
P
M
L
E
Y
F
K
D
K
H
--
I
-
E
-
I
R
F
I
-
E
F
M
D
V
G
N
--
D
N
G
W
D
F
S
K
V
V
T
K
D
E
-----
M
L
T
M
I
E
----------
Q
H
F
E
I
D
P
V
E
P
K
Y
F
------------
G
E
----
V
A
K
Y
Y
R
H
K
D
N
G
V
-------------
Q
F
G
L
-------
I
T
S
V
S
Q
S
F
C
S
T
C
----
T
A
A
A
L
S
S
-------
D
G
K
F
Y
G
C
L
F
A
T
V
-
D
G
F
N
-----
V
K
A
F
I
R
-
S
G
V
T
D
E
E
L
K
-
E
Q
F
K
-
A
L
W
-------
Q
------------------------------------------------------------
3
PsiBlast_PDB
92.34
35%
-112
- C4 -
2FB3
6
MOAA_STAA8
A:
[7-310]
---------------------------------------
D
K
L
G
R
P
I
R
----
D
L
R
L
S
V
T
D
R
---
C
N
F
R
C
D
Y
C
M
P
K
----
E
VFGD
D
F
V
F
----
L
-
P
K
N
E
L
L
T
F
D
E
M
A
R
I
A
K
V
-
Y
---
A
E
---------
L
-
G
---
V
K
K
I
R
I
T
-
G
--
G
-----
E
P
L
M
--
R
--
R
-
D
--
L
-
D
V
L
I
A
K
L
N
Q
---
I
--
D
---
G
--
I
E
D
-----
I
-
G
L
T
T
N
G
L
--------
L
L
-
K
K
-
H
G
Q
K
L
Y
D
A
G
L
R
R
I
N
V
S
L
D
A
I
D
-
D
T
L
F
-
Q
S
---------
I
N
----
N
---
R
N
I
K
A
T
T
I
L
E
Q
I
----------
D
Y
A
T
S
I
----
G
L
N
-
V
K
V
-
N
V
V
-
I
Q
-
K
G
--
I
N
D
D
Q
--
I
I
P
M
L
E
Y
F
K
D
K
H
--
I
-
E
-
I
R
F
I
-
E
F
M
D
V
G
N
--
D
N
G
W
D
F
S
K
V
V
T
K
D
E
-----
M
L
T
M
I
E
----------
Q
H
F
E
I
D
P
V
E
P
K
Y
F
------------
G
E
----
V
A
K
Y
Y
R
H
K
D
N
G
V
-------------
Q
F
G
L
-------
I
T
S
V
S
Q
S
F
C
S
T
C
----
T
R
A
R
L
S
S
-------
D
G
K
F
Y
G
C
L
F
A
T
V
-
D
G
F
N
-----
V
K
A
F
I
R
-
S
G
V
T
D
E
E
L
K
-
E
Q
F
K
-
A
L
W
-------
Q
------------------------------------------------------------
50
Fugue
91.92
33%
-108
- C4 -
1TV8
5
MOAA_STAA8
A:
[3-329]
---------------------------------
E
Q
--
I
K
D
K
L
G
R
P
I
R
----
D
L
R
L
S
V
T
D
R
---
C
N
F
R
C
D
Y
C
M
P
K
EVFG
D
----
D
F
V
F
----
L
-
P
K
N
E
L
L
T
F
D
E
M
A
R
I
A
K
V
Y
A
---
E
----------
L
-
G
---
V
K
K
I
R
I
T
-
G
--
G
-----
E
P
L
M
--
R
--
R
-
D
--
L
-
D
V
L
I
A
K
L
N
Q
---
I
--
D
---
G
--
I
E
D
-----
I
-
G
L
T
T
N
G
L
--------
L
L
-
K
K
-
H
G
Q
K
L
Y
D
A
G
L
R
R
I
N
V
S
L
D
A
I
D
-
D
T
L
F
-
Q
S
---------
I
N
----
N
---
R
N
I
K
A
T
T
I
L
E
Q
I
----------
D
Y
A
T
S
I
----
G
L
-
N
V
K
V
-
N
V
V
-
I
Q
-
K
G
--
I
N
D
D
Q
--
I
I
P
M
L
E
Y
F
K
D
K
H
--
I
-
E
-
I
R
F
I
-
E
F
M
D
V
G
N
--
D
N
G
W
D
F
S
K
V
V
T
K
D
E
-----
M
L
T
M
I
E
----------
Q
H
F
E
I
D
P
-
V
E
P
K
Y
------------
F
G
----
E
V
A
K
Y
Y
R
H
K
D
N
----
G
--------
V
Q
F
G
L
-------
I
T
S
V
S
Q
S
F
C
S
T
C
----
T
R
A
R
L
S
S
-------
D
G
K
F
Y
G
C
L
F
A
T
V
-
D
G
F
N
-----
V
K
A
F
I
R
-
S
G
V
T
D
E
E
L
K
-
E
Q
F
K
A
L
W
Q
-------
I
R
D
D
R
Y
S
---
D
E
R
T
A
Q
T
V
A
N
R
Q
---------------------------------------
25
HHSearch
87.92
33%
-101
- C4 -
1TV8
5
MOAA_STAA8
A:
[5-329]
-------------------------------------
I
K
D
K
L
G
R
P
I
R
----
D
L
R
L
S
V
T
D
R
---
C
N
F
R
C
D
Y
C
M
P
K
----
E
----
V
F
G
D
DFVF
L
-
P
K
N
E
L
L
T
F
D
E
M
A
R
I
A
K
V
Y
----
A
E
---------
L
-
G
---
V
K
K
I
R
I
T
-
G
--
G
-----
E
P
L
M
--
R
--
R
-
D
--
L
-
D
V
L
I
A
K
L
N
Q
---
I
--
D
-------
G
I
E----
D
I
G
L
T
T
N
G
L
--------
L
L
-
K
K
-
H
G
Q
K
L
Y
D
A
G
L
R
R
I
N
V
S
L
D
A
I
D
-
D
T
L
F
-
Q
S
---------
I
N
----
N
R--
N
I
-
K
A
T
T
I
L
E
Q
I
----------
D
Y
A
T
S
I
----
G
L
N
-
V
K
V
-
N
V
V
-
I
Q
-
K
G
--
I
N
D
D
Q
--
I
I
P
M
L
E
Y
F
K
D
K
H
--
I
-
E
-
I
R
F
I
-
E
F
M
D
V
G
N
--
D
N
G
W
D
F
S
K
V
V
T
K
D
E
-----
M
L
T
M
I
E
----------
Q
H
F
E
I
D
P
-
V
E
P
K
Y
------------
F
G
----
E
V
A
K
Y
Y
R
H
K
D
N
----
G
--------
V
Q
F
G
L
-------
I
T
S
V
S
Q
S
F
C
S
T
C
----
T
R
A
R
L
S
S
-------
D
G
K
F
Y
G
C
L
F
A
T
V
-
D
G
F
N
V
K
A
F
I
R
S
G
V
T
D
-
E
E
-
L
K
E
Q
F
K
-
A
L
W
Q
I
R
D
D
-------
R
-
Y
S
D
E
R
T
A
Q
T
V
A
N
-
R
Q
--------------------------------------------
52
Fugue
65.59
17%
-58
- C4 -
4K36
5
ANSME_CLOP1
A:
[2-392]
------
P
P
L
S
L
L
I
K
P
A
-----------------------------------------
S
S
G
---
C
N
L
K
C
T
Y
C
F
Y
H
----
S
----
L
S
D
N
----
V
-
K
S
Y
G
I
M
R
D
E
V
L
E
S
M
V
K
R
V
L
---
N
E
---------
A
N
G
---
H
C
S
F
A
F
Q
-
G
--
G
-----
E
P
T
L
AG
L
--
E
-
F
--
F
-
E
K
L
M
E
L
Q
R
K
---
H
--
N
YKN
L
--
K
I
Y
-----
N
-
S
L
Q
T
N
G
T
--------
L
I
-
D
E
-
S
W
A
K
F
L
S
E
N
K
F
L
V
G
L
S
M
D
G
P
K
-
E
I
H
N
-
L
N
---------
R
K
DCC-
G
---
L
D
-
T
F
S
K
V
E
R
A
A
----------
E
L
F
K
K
Y
----
K
V
-
E
F
N
I
-
L
C
V
-
V
T
-
S
N
--
T
A
R
H
---
V
N
K
V
Y
K
Y
F
K
E
K
D
--
F
K
F
-
L
Q
F
I
-
N
C
L
D
P
L
Y
--
E
E
K
G
K
Y
N
Y
S
L
K
P
K
D
-----
Y
T
K
F
L
K
----------
N
L
F
D
F
W
Y
-
E
D
F
L
N
------------
G
N
R
V
S
I
R
Y
F
D
G
L
L
E
T
I
L
L
G
K
S
S
SCGMNGTC
T
C
Q
F
V
-------
V
E
S
D
G
S
V
Y
--
P
C
----
D
F
Y
V
L
D
K
WRLGNIQ
D
M
T
M
K
E
L
F
E
T
N
K
-
N
-
H
E
-----
F
I
K
L
-
S
-
F
K
V
H
E
E
C
K
K
-
C
K
W
F
R
L
C
K
-------
G
G
C
R
R
C
R
---
D
S
K
E
D
S
A
L
E
L
N
Y
Y
C
Q
S
Y
K
E
F
F
E
Y
A
F
P
R
L
I
N
V
A
N
N
IV
D
K
L
A
A
A
L
E
H
H
H
HHH-
26
HHSearch
57.96
18%
-65
- C4 -
4K36
4
ANSME_CLOP1
A:
[7-312]
----------------------------------------------------
L
I
K
P
A
S
S
G
---
C
N
L
K
C
T
Y
C
F
Y
H
----
S
----
L
S
D
N
-----V
K
S
Y
G
I
M
R
D
E
V
L
E
S
M
V
K
R
V
L
---
N
E
A--------
N
-
G
---
H
C
S
F
A
F
Q
-
G
--
G
-----
E
P
T
L
--
A
--
G
L
E
--
F
F
E
K
L
M
E
L
Q
R
K
---
H
NY
K
---
N
--
L
K
I
-----
Y
N
S
L
Q
T
N
G
T
--------
L
I
-
D
E
S
W
A
K
F
L
S
E
N
K
F
-
L
V
G
L
S
M
D
G
P
K
--
E
I
H
-
N
L
---------
N
R
KDCC
G
---
L
D
-
T
F
S
K
V
E
R
A
A
----------
E
L
F
K
K
Y
----
K
V
E
-
F
N
I
-
L
C
V
-
V
T
-
S
---
N
T
A
R
H
--
V
N
K
V
Y
K
Y
F
K
E
K
D
--
F
-
K
F
L
Q
F
I
-
N
C
L
D
P
L
Y
--
E
E
K
G
K
Y
N
Y
S
L
K
P
K
D
-----
Y
T
K
F
L
K
----------
N
L
F
D
F
W
Y
-
E
--
D
F
------------
L
N
----
G
N
--
R
V
S
I
R
Y
F
----
D
--------
G
L
L
E
T
-------
I
L
L
G
K
S
S
S
C
G
M
N
GTCT
C
Q
F
V
V
E
S
-------
D
G
S
V
Y
P
C
D
F
Y
V
L
D
K
-
W
R
-----
L
G
N
I
Q
D
-
M
T
-----
M
K
-
E
L
F
E
T
N
K
N
-------
H
------------------------------------------------------------
51
Fugue
49.72
18%
-60
- C4 -
4M7T
5
BTRN_BACCI
A:
[21-270]
-----------------------------------------
M
D
K
L
F
S
----
M
I
E
V
E
V
N
S
Q
---
C
N
R
T
C
W
Y
C
P
N
S
----
V
----
S
K
R
K
----
E
-
T
G
--
E
M
D
P
A
L
Y
K
T
L
M
E
Q
L
S
---
S
L
---------
D
-
F
---
A
G
R
I
S
F
H
-
F
Y-
G
-----
E
P
L
L
--
C
--
K
-
N
--
L
-
D
L
F
V
G
M
T
T
E
---
Y
--
I
---
P
--
R
A
R
-----
P
-
I
I
Y
T
N
G
D
--------
F
L
T
E
K
-
R
L
Q
T
L
T
E
L
G
I
Q
K
F
I
V
T
Q
H
A
G
A
-
K
H
K
F
-
R
G
---------
V
Y
----
D
---
Q
----------
L
----------
A
G
A
D
K
E
----
K
V
V
Y
L
D
H
-
S
D
L
-
V
L
-
S
N
--
R
G
G
I
----------------------------------------------------------------------------
L
-
D
N
I
P
A
------------
N
M
----
S
C
M
V
P
S
N
-------------------
L
A
V
-------
V
T
V
L
G
N
V
L
P
C
F
E
----
D
F
N
Q
K
M
V
-------
M
G
N
I
G
--------
E
-
Q
H
-----
I
S
D
I
W
H
-
N
D
K
F
T
S
F
R
K
-
M
L
K
E
G
H
R
G
-------
K
S
D
L
C
K
N
---
C
N
N
V
S
V
Q
T
E
E
Q
Y
D
Y
V
L
-----------------------------------
58
Fugue
49.12
16%
-42
- C4 -
1R30
5
BIOB_ECOLI
A:
[27-338]
-----R
P
R
W
T
L
S
Q
V
T
E
L
F
E
K
P
L
L
D
L
L
F
E
A
Q
Q
V
H
R
Q
--
H
F
D
P
R
Q
V
Q
V
S
----
T
L
L
S
I
K
T
G
A
---
C
P
E
D
C
K
Y
C
P
Q
S
----
S
----
R
Y
K
T
----
G
-
L
E
A
E
R
L
M
E
V
E
Q
V
L
E
S
A
R
K
A
---
K
A
---------
A
-
G
---
S
T
R
F
C
M
G
A
A
--
W
-----
K
N
P
H
--
E
--
R
-
D
--
M
-
P
Y
L
E
Q
M
V
Q
G
---
V
--
K
---
A
--
M
G
L
-----
E
-
A
C
M
T
L
G
T
--------
L
S
-
E
S
-
Q
A
Q
R
L
A
N
A
G
L
D
Y
Y
N
H
N
L
D
T
-
S
-
P
E
F
Y
-
G
N
---------
I
I
----
T
---
T
R
-
T
Y
Q
E
R
L
D
T
L
----------
E
K
V
R
D
A
----
G
I
-
K
V
C
S
-
G
G
I
-
V
G
-
L
G
--
E
T
V
K
D
--
R
A
G
L
L
L
Q
L
A
N
L
P
--
T
-
P
-
P
E
S
V
-
P
I
N
M
L
V
K
VK
G
T
P
L
A
D
N
D
D
V
D
A
F
D
-----
F
I
R
T
I
A
----------
V
A
R
I
M
M
P
-
T
S
-------------------------
Y
V
R
L
S
A
G
R
E
Q
M
N
--------
E
Q
T
Q
A
-------
M
C
F
M
A
G
A
N
S
I
F
Y
----
G
C
K
L
L
T
T
-------
P
N
P
-------
E
E
-
D
-
K
D
-----
L
Q
L
F
R
K
-
L
G
---------------------------------------
L
N
P
Q
Q
T
---------------------------------------
56
Fugue
48.37
15%
-56
- C2 -
4QHW
18
?
A:
[2-401]
Q
P
Q
Q
V
V
V
G
V
S
G
N
G
Y
V
T
R
Q
Q
D
G
A
R
I
T
Q
R
G
V
T
H
W
T
N
P
K
S
I
V
S
I
Y
F
Y
L
H
Q
P
T
T
A
D
L
S
L
Y
A
K
G
H
---
S
E
I
K
V
S
Y
G
K
K
G
----
F
----
K
V
N
L
----
Q
-
S
N
D
F
T
K
V
P
V
G
S
I
D
I
R
Q
A
G
Y
---
V
R
---------
I
-
D
---
L
Q
G
V
S
K
S
-
G
--
E
GFGEI
K
Q
L
I
--
A
--
D
-
N
--
V
-
T
G
K
S
N
Y
V
K
D
---
F
--
S
---
D
--
Y
W
G
-----
R
-
R
G
P
S
V
H
L
--------
G
Y
-
A
L
-
P
E
G
D
-
T
E
W
F
Y
N
E
I
T
V
P
K
E
G
E
T
M
H
S
Y
Y
M
A
A
GFGE
G
Y
F
G
M
Q
Y
----
N
---
S
P
-
T
E
R
R
I
L
F
S
V
W
S
PFDTQNPK
E
I
P
D
D
Q
----
K
I
K
L
L
R
Q
G
K
D
V
-
H
I
-
G
E
--
F
G
N
E
G
S
G
G
Q
S
Y
L
K
Y
P
W
K
A
G
--
N
-
T
-
Y
K
F
L
M
Q
I
R
P
-
D
G
--
N
G
N
T
T
Y
T
A
Y
F
Y
A
T
D
EK
E
W
K
L
I
A
S
F
L
R
P
K
T
N
T
W
YKR
P
H
S
F
L
E
N
-
F
S
P
E
Q
------------
G
Y
----
L
S
R
E
V
F
F
G
N
Q
W
A
R
S
K
E
--------
G
K
W
S
R
-------
L
T
D
A
T
F
T
H
-----------
D
A
T
A
-------
S
A
Q
V
R
L
D
Y
Q
G
G
N
-
T
-
K
D
-----
N
R
F
Y
L
K
M
G
G
F
F
N
E
S
V
P
M
G
T
---
K
F
Y
-------
C
K
P
T
G
K
-----------
E
P
E
I
D
W
E
A
L
K
Q
L--------------------------------
54
Fugue
48.15
12%
-50
- C4 -
1OLT
3
HEMN_ECOLI
A:
[4-444]
------
Q
Q
I
D
W
D
L
A
L
I
K
Y
Y
T
S
Y
P
T
A
L
E
F
S
E
D
F
G
E
Q
--
A
F
L
Q
A
V
A
R
Y
P
----
E
R
P
L
S
L
Y
V
H
IPF
C
H
K
L
C
Y
F
C
G
C
N
----
K
----
I
V
T
R
----
Q
-
Q
H
K
A
D
Q
Y
L
D
A
L
E
Q
E
I
V
H
R
A
---
P
L
---------
F
-
A
GRH
V
S
Q
L
H
W
G
-
G
--
G
-----
T
P
T
Y
LN
K
--
A
-
Q
--
I
-
S
R
L
M
K
L
L
R
E
N
F
Q
F
--
N
---
A
--
D
A
E
-----
I
-
S
I
E
V
D
P
R
--------
E
I
E
L
D
-
V
L
D
H
L
R
A
E
G
F
N
R
L
S
M
G
V
Q
D
F
N
-
K
E
V
Q
-
R
L
---------
V
N
----
R
---
E
Q
-
D
E
E
F
I
F
A
L
L
----------
N
H
A
R
E
I
----
G
F
T
S
T
N
I
-
D
L
I
-
Y
G
L
P
K
--
Q
T
P
E
S
--
F
A
F
T
L
K
R
V
A
E
L
N
--
P
-
D
-
R
L
S
V
-
F
N
Y
A
H
L
P
--
T
I
F
A
A
Q
R
K
I
K
D
A
D
L
-----
P
S
P
Q
Q
K
----------
L
D
I
L
Q
E
T
-
I
A
F
L
T
Q
S
GYQFIGMD
H
F
A
R
----
P
D
D
E
L
A
V
A
Q
R
E
G
V
L
H
R
--------
N
F
Q
G
Y
TTQGD
T
D
L
L
G
M
G
V
S
A
I
S
M
I
----
G
D
C
Y
A
Q
N
-------
Q
K
E
L
K
Q
Y
Y
Q
Q
V
D
-
E
-
Q
G
NA---
L
W
R
G
I
A
-
L
T
R
D
D
C
I
R
R
-
D
V
I
K
S
L
I
C
NFRLD
Y
S
P
I
E
Q
Q
W
D
---
L
L
F
A
D
Y
F
A
E
D
L
K
L
L
A
P
L
A
K
D
GL
V
D
V
D
EK
G
I
Q
V
T
AKGRLL
I
R
N
I
C
M
C
F
DTYL
38
HHSearch
47.34
20%
-63
- C4 -
1R30
4
BIOB_ECOLI
A:
[72-271]
--------------------------------------------------------
K
T
G
A
---
C
P
E
D
C
K
Y
C
P
Q
S
----
S
----
R
Y
K
T
G---
L
-
E
A
E
R
L
M
E
V
E
Q
V
L
E
S
A
R
K
A
----
K
A
---------
A
-
G
---
S
T
R
F
C
M
G
-
A
AW
K
-----
N
P
H
E
--
R
D
M
P
-
Y
--
L
-
E
Q
M
V
Q
G
V
K
A
---
M
----------
G
L
-----
E
-
A
C
M
T
L
G
T
--------
L
S
-
E
S
-
Q
A
Q
R
L
A
N
A
G
L
D
Y
Y
N
H
N
L
D
T
-
S
-
P
E
F
Y
-
G
N
---------
I
I
----
T
---
T
R
-
T
Y
Q
E
R
L
D
T
L
----------
E
K
V
R
D
A
----
G
I
K
-
V
C
S
-
G
G
I
-
V
G
-
L
G
--
E
T
V
K
D
--
R
A
G
L
L
L
Q
L
A
N
L
P
TP
P
-
E
S
V
P
I
N
-
M
L
V
K
V
K
G
--
T
P
L
A
D
-
N
D
D
V
D
A
F
D
-----
F
I
R
T
I
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
46.03
15%
-81
- C4 -
2A5H
5
KAMA_CLOSU
A:
[112-299]
-------------------------------------------
R
Y
P
D
----
R
V
L
L
L
I
T
D
M
---
C
S
M
Y
C
R
H
C
T
R
R
----
R
----
F
A
G
-------
Q
S
D
D
S
M
P
M
E
R
I
D
K
A
I
D
Y
I
----
R
N
T
--------
P
-
Q
---
V
R
D
V
L
L
S
-
G
--
G
-----
D
A
L
L
--
V
--
S
-
D
E
T
L
-
E
Y
I
I
A
K
L
R
E
---
I
----------
P
------
H
V
E
I
V
R
I
G
S
RTPVVLPQ
R
I
-
T
P
E
L
V
N
M
L
K
K
Y
H
P
V
W
L
N
T
H
F
N
H
P
N
-
E
I
----------------------------
T
E
E
S
T
R
A
C
----------
Q
L
L
A
D
A
----
G
V
P
-
L
G
N
-
Q
S
V
-
L
L
-
R
G
VN
D
C
V
H
V
--
M
K
E
L
V
N
K
L
V
K
I
R
--
V
-
R
P
Y
Y
I
Y
-
Q
C
D
L
S
L
G
--
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
44.86
21%
-69
- C4 -
3RFA
2
RLMN_ECOLI
A:
[113-317]
--------------------------------------------
D
R
A
----
T
L
C
V
S
S
Q
V
G
---
C
A
L
E
C
K
F
C
S
T
A
----
Q
----
Q
G
---------
F
N
R
N
L
R
V
S
E
I
I
G
Q
V
W
R
A
A
---
K
I
V
GAAKVTGQ
R
-
P
---
I
T
N
V
V
M
M
-
G
M-
G
-----
E
P
L
L
--
N
--
L
-
N
N
-
V
-
V
P
A
M
E
I
M
L
D
---
D
--
F
-------
G
F
GLSKR
R
V
T
L
S
T
S
G
V
--------
V
P
-
A
L
D
K
L
G
D
M
---
I
D
V
A
L
A
I
S
L
H
A
P
N
-
D
E
I
R
-
D
E
---------
I
V
----
P
INK
K
Y
-
N
I
E
T
F
L
A
A
V
----------
R
R
Y
L
E
K
SNAN
Q
G
R
-
V
T
I
-
E
Y
V
-
M
L
-
D
H
VN
D
G
T
E
H
--
A
H
Q
L
A
E
L
L
K
D
T
P
--
C
-
K
-
I
N
L
I
-
P
W
N
P
F
P
G
--
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
44.10
15%
-69
- C4 -
1OLT
3
HEMN_ECOLI
A:
[50-248]
-------------------------------------------
E
R
P
L
----
S
L
Y
V
H
I
P
-
F
---
C
H
K
L
C
Y
F
C
G
C
N
----
K
----
I
V
T
R
----
Q
-
Q
H
K
A
D
Q
Y
L
D
A
L
E
Q
E
I
V
H
R
A
PLF
A
G
---------
R
-
H
---
V
S
Q
L
H
W
G
-
G
--
G
-----
T
P
T
Y
LN
K
--
A
-
Q
--
I
-
S
R
L
M
K
L
L
R
E
---
N
--
F
---
Q
FN
A
D
A
-----
E
I
S
I
E
V
D
P
R
--------
E
I
-
E
L
D
V
L
D
H
L
R
A
E
G
F
N
R
L
S
M
G
V
Q
D
F
N
-
K
E
V
Q
-
R
L
---------
V
N
----
R
---
E
Q
-
D
E
E
F
I
F
A
L
L
----------
N
H
A
R
E
I
----
G
F
T
S
T
N
I
-
D
L
I
Y
G
L
-
P
K
--
Q
T
P
E
S
--
F
A
F
T
L
K
R
V
A
E
L
N
--
P
-
D
R
L
S
V
F
-
N
Y
A
H
L
P
T
--
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------