@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0959: (2016-04-27 )
MAKSDGDDPLRPASPRLRSSRRHSLRYSAYTGGPDPLAPPVDLRDALEQIGQDVMAGASPRRALSELLRRGTRNLTGADRLAAEVNRRRRELLRRNNLDGTLQEIKKLLDEAVLAERKELARALDDDARFAELQLDALPASPAKAVQELAEYRWRSGQAREKYEQIKDLLGRELLDQRFAGMKQALAGATDDDRRRVTEMLDDLNDLLDKHARGEDTQRDFDEFMTKHGEFFPENPRNVEELLDSLAKRAAAAQRFRNSLSQEQRDELDALAQQAFGSPALMRALDRLDAHLQAARPGEDWTGSQQFSGDNPFGMGEGTQALADIAELEQLAEQLSQSYPGASMDDVDLDALARQLGDQAAVDARTLAELERALVNQGFLDRGSDGQWRLSPKAMRRLGETALRDVAQQLSGRHGERDHRRAGAAGELTGATRPWQFGDTEPWHVARTLTNAVLRQAAAVHDRIRITVEDVEVAETETRTQAAVALLVDTSFSMVMENRWLPMKRTALALHHLVCTRFRSDALQIIAFGRYARTVTAAELTGLAGVYEQGTNLHHALALAGRHLRRHAGAQPVVLVVTDGEPTAHLEDFDGDGTSVFFDYPPHPRTIAHTVRGFDDMARLGAQVTIFRLGSDPGLARFIDQVARRVQGRVVVPDLDGLGAAVVGDYLRFRRR
Atome Classification :
(20 SA)
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20........30.-.....--------..40........50------------.........60........70........80........90------.-----------------.......100.......110.......120.....---------------..130.....---------..140.----......150.....----.--.160.-----------.....--.-----170.......180........190----...-....200.......210.......220.......230....------...240.......250.......260.....---..270.......280.......290.......300.......310....-...320...------....330.......340.....--..350------.........360--..----------------......370.......380..--.....390.......400.......410......-----.420.......430.......440.......450.......460.......470--.........480.......490.....----.----------.500.....-------------..510.......520...-------------------------------....-530...-.------------------------------..-------------.----------.----------540---..----.-.--....-------550----...--------------....560---....-----.-----.---.570...---....580.......590-----...---------------....600.......610.......620.......630-----------------..--------.....640...----.-.----..-650.---.-.....660--....-.----..---..670--------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAKSDGDDPLRPASP
R
L
R
S
SRRH
S
L
R
YSAYTG-GPDPL--------APPV
D
L
R
D
A
L
E
Q
I
-------------
G
Q
D
V
MAGA
S
P
R
R
A
L
S
E
L
L
R
R
GTRNLT
G
A
D
R
L
A
A
E
V
N
R
R
R
R
E
------
L
-----------------
L
R
RNNL
D
G
T
L
Q
E
I
K
K
L
L
D
E
A
V
L
A
E
R
K
E
L
A
R
ALDDD---------------A
R
F
A
E
L
Q
L
DA---------LPA
S
P
A
----
K
A
V
Q
E
L
A
E
Y
RWRSG----Q--
A
R
E
K
Y
-----------
E
Q
I
K
D
--
L
-----
L
G
R
E
L
L
D
Q
R
F
A
-
G
M
K
Q
A
LAGAT
D
D
----
D
R
R
-
R
V
T
E
M
L
D
D
L
N
D
L
L
D
K
HARGE
D
T
Q
R
D
F
D
E
F
M
T
KHGEFFPENP------R
N
V
E
E
L
L
D
S
L
A
K
R
A
A
A
A
Q
R
F
R
N
SL
S
Q
E
Q
R
D
E
---
L
D
A
L
A
Q
Q
AFG
S
P
A
L
M
R
A
L
D
R
L
D
A
H
L
QAARPGEDWTGSQQFSGDNPFGMG-
E
G
T
Q
A
L
A
D
I
------
A
E
L
E
Q
L
A
E
Q
L
S
Q
SYPGASMDDV--
D
L
D
--------
A
L
A
R
QLGDQAA---
V
D
----------------
A
R
T
L
A
E
L
E
R
A
L
V
NQGFLDRGS--DG
Q
W
R
L
S
P
K
A
M
R
R
L
G
E
T
A
L
R
D
V
A
Q
Q
L
SGRHGE
R
D
-----
H
RRAGAAGELTGATRPWQFGDTE
P
W
H
V
A
R
T
L
T
N
A
V
L
R
Q
A
A
A
VH
D
R
I
R
I
T
V
E
D
----
V
E
VAETETRT
Q
A
A
V
A
L
L
VDT
S
F
S
M
V
M
E----N----------RWLP
M
K
R
T
A
-------------
L
A
L
H
H
L
V
C
T
R
F
RSD
A
L
Q
I
-------------------------------
I
A
FG-R-
Y
A
R
T
-
V
------------------------------
T
A
-------------
A
----------
E
----------
L
T
----GL----
A
-
G
--
V
Y
EQ-------GT
N
----
L
H
H
--------------
A
L
A
L
A
G
R
---
H
L
R
R
-----H-----A---GAQ
P
V
V
L
---
V
V
TDGEPTAHLEDFDGD-----G
T
S
---------------
V
F
FDYPPH
P
R
T
I
A
H
T
V
R
G
F
D
D
M
A
RLG
A
Q
V
T
I
F
R
LGSD-----------------P
G
--------
L
A
R
F
I
D
Q
V
A
R
R----V-Q----G
R
-
V
VVP---D-LDG
L
G
A
----
A
V
V
G
-
D
----
Y
L
---
R
FRRR--------------------------------------------
39
Fugue
67.18
13%
-33
* C7 *
1YVR
-
RO60_XENLA
A:
[5-537]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
D
Q
T
Q
P
L
N
E
K
Q
V
P
N
S
E
G
C
Y
V
W
Q
V
------------------------
S
D
M
N
R
L
-------------
R
R
F
L
C
F
G
-----------
S
E
G
G
T
Y
Y
I
E
E
K
K
L
G
Q
E
N
A
E
A
L
L
R
------
L
-----------------
I
E
D
G
K
G
C
E
V
V
Q
E
I
K
T
F
S
Q
E
G
R
A
A
K
Q
E
P
T
L
F
A
L
------------------
A
V
C
S
Q
C
S
D
I
K
---------
T
K
Q
A
A
F
----
R
A
V
P
E
V
C
R
I
P
T
H
L
F
----
T
--
F
I
Q
F
K
-----------
K
D
L
W
G
--
R
-----
A
L
R
K
A
V
S
D
W
Y
N
-
T
K
-------------------------
D
A
L
N
L
A
M
A
V
T
K
Y
K
Q
R
N
G
-----
W
S
H
K
D
L
L
R
L
S
H
I
------
K
P
A
N
E
G
L
T
M
V
A
K
Y
V
S
--
K
G
W
K
E
V
Q
E
A
Y
K
E
K
E
---
L
S
P
E
T
E
K
V
L
K
Y
L
E
A
T
E
R
V
K
R
T
K
D
E
L
E
I
I
H
L
I
D
E
Y
R
L
V
R
E
H
--------------
L
L
T
I
H
------
L
K
S
K
E
I
W
K
S
L
L
Q
D
M
P
----------
L
T
--------
A
L
L
R
N
L
G
K
M
T
A
---
D
S
----------------
V
L
A
P
A
S
S
E
V
S
S
V
C
E
R
L
T
N
------------
E
K
L
L
K
K
A
R
I
H
P
F
H
I
L
V
A
L
E
T
Y
K
K
G
H
L
R
-----
W
I
P
----------------------------
D
T
S
I
V
E
A
L
D
N
A
F
Y
K
-------------
S
F
K
L
V
E
P
T
G
K
R
F
L
L
A
I
D
V
S
A
S
M
N
Q
R
----
V
----------
L
G
S
I
L
N
A
S
V
-------------
V
A
A
A
M
C
M
L
V
A
R
T
E
K
D
S
H
M
-------------------------------
V
A
F
S
-
D
-
E
M
L
P
-
C
------------------------------
P
I
-------------
T
----------
V
----------
N
M
----
L
L
----
H
-
E
--
V
V
E
K
M
S
DI
T
M
G
S
T
D
----
C
A
L
--------------
P
M
L
W
A
Q
K
---
T
N
T
A
-----------------
A
D
I
F
I
---
V
F
T
D
C
E
T
N
--------------------------------------
V
E
D
V
H
P
A
T
A
L
K
Q
Y
R
E
K
M
G
I
P
A
K
L
I
V
C
A
M
T
S
N
-----------------
G
F
--------
S
I
A
D
P
D
D
R
G
M
L
----
D
-
I
----
C
G
-
F
D
S
G
---
A
-
L
D
V
I
R
N
----
F
T
L
D
-
L
----------------------------------------------------------
45
Fugue
66.20
18%
-23
- C2 -
4OGE
6
CAS9_ACTNH
A:
[10-1101]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H
H
L
R
V
G
I
D
V
G
TH
S
V
G
L
A
T
L
R
V
D
DHGTPIELL
S
A
L
S
H
I
H
DLS
G
I
A
R
R
A
R
R
L
L
H
H
R
R
T
Q
L
Q
Q
L
D
E
V
L
R
D
L
GFPIPS
M
A
V
R
H
I
A
R
H
R
GWRNPYSKVESLLSPAEESPFMKRK
I
C
A
R
Q
G
V
S
P
D
V
C
K
Q
L
L
R
A
V
F
K
A
D
S
P
R
G
S
A
V
S
R
V
A
P
D
P
L
PGQGSFRR
A
P
K
C
D
P
E
F
Q
R
F
R
I
I
S
I
V
A
N
L
R
I
S
ETK
G
E
N
R
P
L
T
A
D
E
R
R
H
V
V
T
F
L
T
E
D
S
Q
A
D
L
T
W
V
D
V
A
E
K
L
G
V
H
R
R
D
------
L
RGTAVHTRSAARPPID
A
T
D
R
I
M
R
Q
T
K
I
S
S
L
K
T
W
W
E
E
A
D
S
E
Q
R
G
A
M
I
R
Y
L
Y
E
D
PTD
S
E
C
A
E
I
I
AELPE
E
D
Q
A
K
L
D
S
L
H
---------
L
P
A
G
R
A
AYS
R
E
S
L
T
A
L
S
D
H
M
L
A
T
T
DD
L
H
E
--
A
R
K
R
L
FGVDDS
W
A
P
P
A
E
A
I
N
A
--
P
-----
V
G
N
P
S
V
D
R
T
L
K
-
I
V
G
R
Y
L
S
A
V
E
S
M
WGTP
E
V
I
-
H
V
E
H
V
R
D
G
F
T
S
E
R
M
A
D
E
R
D
K
A
N
R
R
R
Y
N
D
N
Q
E
A
M
K
K
I
Q
R
D
Y
G
KEGYIS
R
G
D
I
V
R
L
D
A
L
E
L
Q
G
C
A
C
L
Y
C
G
T
T
I
G
Y
H
T
C
Q
L
---
D
H
I
V
P
Q
A
G
P
G
S
N
N
R
R
G
N
L
V
A
V
C
E
R
C
N
R
S
K
S
N
T
P
F
A
V
W
A
Q
K
C
G
I
P
H
V
G
V
K
-
E
A
I
G
R
V
R
G
W
RKQTS
S
E
D
L
T
R
L
K
K
E
V
I
A
R
L
R
R
-
T
Q
E
D
P
--
E
I
D
ERSMESVA
W
M
A
N
E
L
H
H
R
I
A
---
A
A
Y
P
E
T
T
V
M
V
Y
R
GS
I
T
A
A
A
R
K
A
A
G
I
D
S
R
I
N
L
I
G
E
K
G
R
K
D
RI
D
R
R
H
H
A
V
D
A
S
V
V
A
L
M
E
A
S
V
A
K
T
L
A
E
R
S
S
L
R
G
E
Q
R
L
T
GKE
Q
T
W
K
Q
Y
T
G
S
T
V
G
A
R
E
H
F
E
M
W
R
G
H
M
L
H
L
T
E
L
F
N
E
R
L
A
E
D
K
V
Y
V
T
Q
N
I
R
L
R
L
S
D
GNAH
T
V
N
P
S
K
L
V
S
H
R
L
G
D
G
L
T
V
Q
Q
I
D
R
A
C
T
P
----
A
----------
L
W
C
A
L
T
R
E
K
DFDEKNGLPARED
R
A
I
R
V
H
G
H
E
I
K
S
S
D
Y
I
Q
V
F
S
KRKKTDSDRD
E
T
P
F
G
A
I
A
V
RG
G
F
V
E
IGPS
I
H
H
A
-
R
-
I
Y
R
V
-
E
------------------------------
G
K
-------------
K
----------
P
----------
V
Y
----
A
M
----
L
-
R
--
V
F
T
H
-------
D
L
L
----
S
Q
R
HGDLFSAVIPPQS
I
S
M
R
C
A
E
P
---
K
L
R
K
-----
A
-----
I
---
T
T
G
N
A
T
Y
L
G
W
V
V
V
G
D
E
L
E
I
N
V
D
S
F
T
K
Y
-----
A
I
G
---------------
R
F
L
E
D
F
P
N
--
T
T
R
W
R
I
C
G
Y
D
T
N
S
K
L
T
L
K
P
I
V
L
A
A
E
G
L
-----------------
E
N
--------
P
S
S
A
V
N
E
I
V
E
L
----
K
-
G
----
W
R
-
V
A
I
N
---
V
-
L
T
K
V
H
P
----
T
V
V
R
R
D
----
A
L
GRP
R
Y
S
S
R
SN
L
P
T
S
W
T
IE----------------------------------
44
Fugue
65.74
17%
-22
- C1 -
4LLG
-
RPOD_ECOLI
F:
[6-612]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
Q
L
K
L
L
V
T
R
G
K
E
Q
G
Y
L
T
Y
A
E
-
V
N
D
H
L
--------
P
E
D
I
V
D
S
D
Q
I
E
D
I
-------------
I
Q
M
I
----------------
N
D
M
G
I
Q
V
M
G
R
T
T
D
P
V
R
M
Y
M
R
E
------
M
-----------------
G
T
V
E
L
L
T
------------------
R
E
G
E
I
D
I
A
K
R
---------------
I
E
D
G
I
N
Q
V
Q
C
---------
S
V
A
E
Y
P
----
E
A
I
T
Y
L
L
E
Q
Y
D
R
V
E
----
A
--
E
E
A
R
L
-----------
S
D
L
I
T
GF
V
-----
D
D
P
E
L
A
R
E
K
F
A
-
E
L
R
A
Q
Y
V
V
T
R
D
T
----
I
K
A
-
T
A
Q
E
E
I
L
K
L
S
E
V
F
K
Q
F
R
L
V
P
K
Q
F
D
Y
L
V
N
S
M
R
V
M
M
D
R
V
R
T
Q
E
------
R
L
I
M
K
L
C
V
E
Q
C
K
M
P
--
K
K
N
F
I
T
L
F
T
G
N
E
T
S
D
TWF
N
A
A
I
A
M
N
K
P
W
S
E
K
L
H
D
V
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
I
E
E
E
T
G
L
T
--------------------
I
------
E
Q
V
K
D
I
N
R
R
M
S
I
G
E
A
K
A
R
R
A
K
K
--
E
M
V
--------
E
A
N
L
R
L
V
I
S
I
A
----------------------------------
K
K
Y
T
N
R
G
--------
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
------------------------
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
----
R
T
I
R
I
P
V
H
M
----
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
-----------
L
Q
----
E
----------
M
G
R
E
P
T
P
E
E
-------------
L
A
E
R
M
L
M
P
E
D
K
I
R
K
V
L
K
I
-------------------------------
A
K
E
P
-
I
-
S
M
E
T
-
P
------------------------------
I
G
-------------
D
----------
D
----------
E
D
----
S
H
----
L
-
G
--
D
F
I
E
-------
D
T
T
----
L
E
L
--------------
P
L
D
S
A
T
T
---
E
S
L
R
-----
A
-----
A
---
T
H
D
V
L
A
G
---
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
-----
N
T
D
----------------------------------
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
---------------------------------
E
R
I
R
Q
I
E
A
K
----
A
-
L
----
R
K
-
L
R
H
P
---
S
-----
R
S
----
E
V
L
R
-
S
----
F
L
---
D
------------------------------------------------
26
HHSearch
58.10
18%
-90
- C9 -
1SHU
1
ANTR2_HUMAN
X:
[5-171]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
F
D
L
Y
F
V
L
D
K
S
G
S
V
A
N
----------------
N
W
I
E
I
Y
N
F
V
-------------
Q
Q
L
A
E
R
F
V
S
--
P
E
M
R
L
S
F
-------------------------------
I
V
F
S
-
S
-
Q
A
T
I
-
I
------------------------------
L
P
LTGDR--------
G
----------
K
ISKG------
L
E
----
D
L
----
K
-
R
V-
S
P
V
G
-------
E
T
Y
----
I
H
E
--------------
G
L
K
L
A
N
E
---
Q
I
Q
K
-----
A
-----
G
GL-
K
T
S
S
I
I
I
---
A
L
T
D
G
K
L
D
G
L
V
P
------------
S
----------------------------
Y
A
E
K
E
A
K
I
S
R
S
L
G
A
S
V
Y
C
V
G
V
L
D
F
---------------------------
E
Q
A
Q
L
E
R
I
A
D
S
----
K
-
E
----
Q
V
-
F
P
V
K
G--
G
-
F
Q
A
L
K
---------------------------------------------------------------------
17
HHSearch
57.37
18%
-81
- C9 -
4FX5
1
?
A:
[76-248]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
N
V
E
V
I
I
I
D
C
S
G
S
M
D
Y
P
R---
T
----------
K
M
M
A
A
K
E
A
T
-------------
K
V
---
A
I
D
T
L
T
D
G
A
F
F
A
V
-------------------------------
V
A
G
T
-
E
-
G
A
R
V
-
V
------------------------------
Y
P
-------------
T
GG
Q
L
L
R
AD
Y
Q
S
----------
R
A
A
A
K
E
A
V
----
G
-
R
L
-
H
A
N
G
-------
G
T
A
----
M
G
R
--------------
W
L
A
Q
A
G
R
---
I
F
D
T
-----
A
-----
P
---
S
A
I
K
H
A
I
---
L
L
T
D
G
K
D
E
S
E
T
P
-------------------------------------
A
---
D
L
A
R
A
I
Q
S
-
S
I
G
N
F
T
A
D
C
R
G
I
G
E
D
-----------------
W
E
---------
P
K
E
L
R
K
I
A
D
A
----
L
-
L
----
G
T
-
V
G
I
I
---
R
D
P
A
T
L
A
E
--------------------------------------------------------------------
16
HHSearch
56.73
20%
-87
- C9 -
4RCK
2
?
A:
[17-210]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
R
D
M
M
L
V
V
D
L
S
G
S
M
A
E
E
----
D
MKTSN
G
D
F
V
D
R
L
T
A
V
K
Q
V
V
-------------
S
---
D
F
I
D
Q
-
R
K
G
D
R
L
G
L
-------------------------------
V
L
F
G
-
D
-
H
A
Y
L
-
Q
------------------------------
T
P
LTFD
R
N
T
V
R
----
E
----------
Q
----------
L
D
----
R
T
----
V
L
N
--
L
V
G
Q
-------
R
T
A
----
I
G
E
--------------
G
L
G
L
A
T
K
---
T
F
I
E
-----
S
-----
N
---
A
P
Q
R
T
I
I
---
L
L
S
D
G
A
N
T
A
G
V
L
-----------------------------------
E
------
P
L
E
A
A
Q
L
A
K
D
N
H
A
K
I
Y
T
V
G
I
G
A
G
E
M
Q
V
R
G
FF
G
K
Q
T
V
NTAR
D
L
--------
D
E
D
T
L
T
K
I
A
T
M
----
T
-
G
----
G
Q
-
Y
F
R
A
---
R
N
A
D
E
L
A
E
--------------------------------------------------------------------
32
HHSearch
55.06
19%
-80
- C9 -
4HQO
3
?
A:
[16-196]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
Q
V
D
L
Y
L
L
V
D
G
S
G
S
I
G
Y
P
----
N
----------
W
I
T
K
V
I
P
M
L
-------------
N
G
L
I
N
S
L
S
L
S
R
D
T
I
N
L
Y
M
-------------------------------
N
L
F
G
-
S
-
Y
T
T
E
-
L
------------------------------
I
R
LGSGQSID
K
R
Q
A
L
S
----------
K
----------
V
T
----
E
L
----
R
-
K
T
Y
T
P
Y
G
-------
T
T
S
----
M
T
A
--------------
A
L
D
E
V
Q
K
---
H
L
N
D
-----
R
VNR--
E
---
K
A
I
Q
L
V
I
---
L
M
T
D
G
V
P
N
S
K
Y
R
------------------------------------------
A
L
E
V
A
N
K
L
K
Q
R
N
V
R
L
A
V
I
G
I
G
Q
G
-----------------
I
N
---------
H
Q
F
N
R
L
I
A
G
C
RPRE
P
-
N
----
C
K
-
F
Y
S
Y
A--
D
-
W
N
E
A
V
---------------------------------------------------------------------
37
HHSearch
53.18
15%
-97
- C9 -
3T3P
5
ITB3_HUMAN
B:
[109-348]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
P
V
D
I
Y
Y
L
M
D
L
S
Y
S
M
K
D
----------------
D
L
W
S
I
Q
N
L
G
-------------
T
K
L
A
T
Q
M
R
K
L
T
S
N
L
R
I
G
F
-------------------------------
G
A
F
V
-
D
-
K
P
V
S
P
Y
MYISP
P
E
A
L
E
NPCYDMK
T
T
C
L
PMFG
Y
K
H
V
L
T
L
T------------
D
----------
Q
----------
V
T
----
R
F
N
E
E
V
K
-
K
Q
-
S
V
S
R
-------
N
R
D
APEG
G
F
D
--------------
A
I
M
Q
A
T
V
CDE
K
I
G
W
-----
R
-----
N
---
D
A
S
H
L
L
V
---
F
T
T
D
A
K
T
H
I
A
L
---
D
G
R
LAGIV
Q
P
N
DGQCHVGSDNHYSAS
T
T
M
D
Y
P
-
S
------
L
G
L
M
T
E
K
L
S
Q
K
N
I
N
L
I
F
A
V
T
E
N
V
----------------------------
V
N
L
Y
Q
N
Y
S
E
L
----
I
-
P
----
G
T
-
T
V
G
V
L
S
M
D
-
S
S
N
V
L
Q
----
L
I
V
D
-
A
----
Y
-----------------------------------------------------
23
HHSearch
53.16
13%
-87
- C9 -
2X5N
3
RPN10_SCHPO
A:
[2-160]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
A
T
M
I
L
I
D
N
S
E
W
M
I
N
G
DYIP
T
----------
R
F
E
A
Q
K
D
T
V
-------------
H
M
I
F
N
Q
K
I
N
D
N
P
E
N
M
C
G
L
-------------------------------
M
T
I
G
-
D
N
S
P
Q
V
-
L
------------------------------
S
T
-------------
L
TRD
Y
G
K
F
L
S
-
A
----------
M
H
----
D
L
----
P
-----
V
R
G
-------
N
A
K
----
F
G
D
--------------
G
I
Q
I
A
Q
L
---
A
L
K
H
-----
R
------NKI
Q
R
Q
R
I
V
A
---
F
V
G
S
P
I
V
E
D
E
-----
K
--------
N
-----------------------------
L
I
R
L
A
K
R
M
K
K
N
N
V
A
I
D
I
I
H
I
G
E
L
-----------------------------
S
A
L
Q
H
F
I
D
A
----
A
-
N
------------------------------------------------------------------------------------------
25
HHSearch
52.98
19%
-92
- C9 -
3N2N
5
ANTR1_HUMAN
F:
[6-175]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
F
D
L
Y
F
I
L
D
K
S
G
S
V
L
H
----------------
H
W
N
E
I
Y
Y
F
V
-------------
E
Q
L
A
H
K
F
I
S
--
P
Q
L
R
M
S
F
-------------------------------
I
V
F
S
-
T
-
R
G
T
T
-
L
------------------------------
M
K
LTEDR--------
E
----------
Q
IRQG------
L
E
----
E
L
----
Q
-
K
V-
L
P
G
G
-------
D
T
Y
----
M
H
E
--------------
G
F
E
R
A
S
E
---
Q
I
Y
Y
-----
E
NRQG-
Y
---
R
T
A
S
V
I
I
---
A
L
T
D
G
E
L
H
E
D
L
F
--------------------------------
F
--------
Y
S
E
R
E
A
N
R
S
R
D
L
G
A
I
V
Y
A
V
G
V
K
D
F
---------------------------
N
E
T
Q
L
A
R
I
A
D
S
----
K
-
D
----
H
V
-
F
P
V
N
---
D
G
F
Q
A
L
Q
G
--------------------------------------------------------------------
33
HHSearch
51.87
18%
-88
* C9 *
1V7P
1
ITA2_HUMAN
C:
[6-176]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
D
V
V
V
V
C
D
E
S
N
S
I
Y
P
-----------------
W
D
A
V
K
N
F
L
-------------
E
K
F
V
Q
G
L
D
I
G
P
T
K
T
Q
V
G
L
-------------------------------
I
Q
Y
A
-
N
-
N
P
R
V
-
V
------------------------------
F
N
L------------
N
TYKT
K
E
----
E
M
I
V
A
------
T
S
----
Q
T
----
S
-
Q
--
Y
G
G
D
-------
L
T
N
----
T
F
G
--------------
A
I
Q
Y
A
R
K
---
Y
A
Y
S
-----
A
ASGGR
R
---
S
A
T
K
V
M
V
---
V
V
T
D
G
E
S
H
D
G
S
M
------------------------------------------
L
K
A
V
I
D
Q
C
N
H
D
N
I
L
R
F
G
I
A
V
L
G
Y
-----------------
L
N
R
N
ALDT
K
N
L
I
K
E
I
K
A
I
A
S
I
----
P
-
T
----
E
R
-
Y
F
F
--------------------------------------------------------------------------------
19
HHSearch
50.90
18%
-107
- C9 -
4WFQ
-
SSL1_YEAST
A:
[4-182]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
R
S
L
I
L
T
L
D
C
S
E
A
M
L
E
K
DLRP
N
----------
R
H
A
M
I
I
Q
Y
A
-------------
I
D
F
V
H
E
F
F
D
Q
N
P
I
S
Q
M
G
I
-------------------------------
I
I
M
R
N
G
-
L
A
Q
L
-
V
------------------------------
S
Q
VSGN
P
--------
Q
D
H
I
D
------
A
----------
L
K
----
S
I
----
R
-
K
Q
-
E
P
K
G
-------
N
P
S
----
L
Q
N
--------------
A
L
E
M
A
R
G
---
L
L
L
P
-----
V
-----
P
AH-
C
T
R
E
V
L
I
---
V
F
G
S
L
S
T
T
D
P
-----
G
--------
D
--------------------------
I
H
---
Q
T
I
D
S
L
V
S
E
K
I
R
V
K
V
L
G
L
S
A
Q
----------------------------
V
A
I
C
K
E
L
C
K
A
----
T
-
N
YGDE
S
F
-
Y
K
I
L
L--
D
-
E
T
H
L
K
E
----
L
---------------------------------------------------------------
29
HHSearch
50.86
15%
-84
- C9 -
1MF7
-
ITAM_HUMAN
A:
[131-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
S
D
I
A
F
L
I
D
G
S
G
S
I
I
P
H
---------------
D
F
R
R
M
K
E
F
V
-------------
S
T
V
M
E
Q
L
K
K
--
S
K
T
L
F
S
L
-------------------------------
M
Q
Y
S
-
E
-
E
F
R
I
-
H
------------------------------
F
T
F
------------
K
E
F
Q
N
N
P----
N
P
R
S
L
------
V
K
----
P
I
----
T
-
Q
---
L
L
G
-------
R
T
H
----
T
A
T
--------------
G
I
R
K
V
V
R
---
E
L
F
N
-----
I
TNGAR
K
---
N
A
F
K
I
L
V
---
V
I
T
D
G
E
K
F
G
D
P
L
-----------------------------------------
G
Y
E
D
V
I
P
E
A
D
R
E
G
V
I
R
Y
V
I
G
V
G
D
A
-----------------
F
R
SEK-----
S
R
Q
E
L
N
T
I
A
S
K
----
P
-
P
----
R
D
H
V
F
Q
--------------------------------------------------------------------------------
35
HHSearch
50.77
18%
-92
- C9 -
4BJ3
4
ITA2_HUMAN
A:
[23-193]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
D
V
V
V
V
C
D
E
S
N
S
I
Y
P
-----------------
W
D
A
V
K
N
F
L
-------------
E
K
F
V
Q
G
L
D
I
G
P
T
K
T
Q
V
G
L
-------------------------------
I
Q
Y
A
-
N
-
N
P
R
V
-
V
------------------------------
F
N
L------------
N
TYKT
K
E
----
E
M
I
V
A
------
T
S
----
Q
T
----
S
-
Q
--
Y
G
G
D
-------
L
T
N
----
T
F
G
--------------
A
I
Q
Y
A
R
K
---
Y
A
Y
S
AASGG
R
-----
R
---
S
A
T
K
V
M
V
---
V
V
T
D
G
E
S
H
D
G
S
M
------------------------------------------
L
K
A
V
I
D
Q
C
N
H
D
N
I
L
R
F
G
I
A
V
L
G
Y
-----------------
L
N
RN
A
L
D
T
K
N
L
I
K
E
I
K
A
I
A
S
I
----
P
-
T
----
E
R
-
Y
F
F
--------------------------------------------------------------------------------
24
HHSearch
50.18
17%
-88
- C9 -
1N3Y
-
ITAX_HUMAN
A:
[129-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
Q
D
I
V
F
L
I
D
G
S
G
S
I
S
S
R
---------------
N
F
A
T
M
M
N
F
V
-------------
R
A
V
I
S
Q
F
Q
R
--
P
S
T
Q
F
S
L
-------------------------------
M
Q
F
S
-
N
-
K
F
Q
T
-
H
------------------------------
F
T
F
------------
E
----------
E
F
R
R
SSN----
P
L
S
---
L
L
----
A
-
S
VH
Q
L
Q
G
-------
F
T
Y
----
T
A
T
--------------
A
I
Q
N
V
V
H
---
R
L
F
H
ASYGA
R
-----
R
---
D
A
A
K
I
L
I
---
V
I
T
D
G
K
K
E
G
D
S
L
---
D
-----------------------------------
Y
---
K
D
V
I
P
M
A
D
A
A
G
I
I
R
Y
A
I
G
V
G
L
A
-----------------
F
Q
N
R
N
-----
S
W
K
E
L
N
D
I
A
S
K
----
P
-
S
Q---
E
H
-
I
F
K
V
E--
D
-
F
D
A
L
K
---------------------------------------------------------------------
8
PsiBlast_PDB
50.07
20%
-14
- C6 -
4UOS
-
?
A:
[9-170]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
K
M
I
E
E
I
K
K
M
L
E
K
A
I
K
K
V
K
E
M
L
E
K
M
I
K
E
I
---------------
K
K
M
L
E
N
G
E
D
S
E
K
I
L
K
K
A
K
E
M
A
E
K
I
L
----
K
M
V
I
E
L
A
E
K
I
L
K
K
A
----
K
E
M
A
E
K
I
L
-----------
K
K
V
K
E
--
L
GVDN
E
E
V
K
K
M
L
E
K
M
I
E
-
E
I
K
K
M
L
E
K
A
I
K
K
----
V
K
E
-
M
L
E
K
M
I
K
E
I
K
K
M
L
E
N
---
G
E
D
S
E
K
----
I
L
K
K
A
K
E
M
A
E
K
I
L
------
K
M
V
I
E
L
A
E
K
I
L
K
K
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
49.35
14%
-96
- C9 -
1PT6
2
ITA1_HUMAN
A:
[7-177]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
D
I
V
I
V
L
D
G
S
N
S
I
Y
P
-----------------
W
D
S
V
T
A
F
L
-------------
N
D
L
L
K
R
M
D
I
G
P
K
Q
T
Q
V
G
I
-------------------------------
V
Q
Y
G
-
E
-
N
V
T
H
-
E
------------------------------
F
N
L------------
N
----------
K
YSS
T
E
E
V
L
V
A
A
K
----
K
I
----
V
-
Q
--
R
G
G
R
-------
Q
T
M
----
T
A
L
--------------
G
T
D
T
A
R
K
---
E
A
F
T
EAR
G
A
R
-----
R
---
G
V
K
K
V
M
V
---
I
V
T
D
G
E
S
H
D
N
H
R
------------------------------------------
L
K
K
V
I
Q
D
C
E
D
E
N
I
Q
R
F
S
I
A
I
L
G
S
-----------------
Y
N
R
G
NLST
E
K
F
V
E
E
I
K
S
I
A
S
E
----
P
-
T
----
E
K
-
H
F
F
--------------------------------------------------------------------------------
46
Fugue
48.50
17%
-4
- C4 -
4F92
1
U520_HUMAN
B:
[2-1724]
LAPRQVLDLEDLVFTQGSHFMANKRCQLPDGSFRRQRKGYEEVHVPALKPKPFGSEEQLLPVEKLPKYAQAGFEGFKTLNRIQSKLYRAALETDENLLLCAPTGAGKTNVALMCMLREIGKHINMDGTINVDDFKIIYIAPMRSLVQEMVGSFGKRLATYGITVAELTGDHQLCKEEISATQIIVCTPEKWDIITRKGGERTYTQLVRLIILDEIHLLHDDRGPVLEALVARAIRNIEMTQEDVRLIGLSATLPNYEDVATFLRVDPAKGLFYFDNSFRPVPLEQTYVGITEKKAIKRFQIMNEIVYEKIMEHAGKNQVLVFVHSRKETGKTARAIRDMCLEKDTLGLFLREGSASTEVLRTEAEQCKNLELKDLLPYGFAIHHAGMTRVDRTLVEDLFADKHIQVLVSTATLAWGVNLPAHTVIIKGTQVYSPEKGRWTELGALDILQMLGRAGRPQYDTKGEGILITSHGELQYYLSLLNQQLPIESQMVSKLPDMLNAEIVLGNVQNAKDAVNWLGYAYLYIRMLRSPTLYGISHDDLKGDPLLDQRRLDLVHTAALMLDKNNLVKYDKKTGNFQVTELGRIASHYYITNDTVQTYNQLLKPTLSEIELFRVFSLSSEFKNITVREEEKLELQKLLERVPIPVKESIEEPSAKINVLLQAFISQLKLEGFALMADMVYVTQLAGRLMRAIFEIVLNRGWAQLTDKTLNLCKMIDKRMWQSMCPLRQFRKLPEEVVKKIEKKNFPFERLYDLNHNEIGELIRMPKMGKTIHKYVHLFPKLELSVHLQPITRSTLKVELTITPDFQWDEKVHGSSEAFWILVEDVDSEVILHHEYFLLKAKYAQDEHLITFFVPVFEPLPPQYFIRVVSDRWLSCETQLPVSFRHLILPEKYPPPTELLDLQPLPVSALRNSAFESLYQDKFPFFNPIQTQVFNTVYNSDDNVFVGAPTGSGKTICAEFAILRMLLQSSEGRCVYITPMEALAEQVYMDWYEKFQDRLNKKVVLLTGETSTDLKLLGKGNIIISTPEKWDILSRRWKQRKNVQNINLFVVDEVHLIGGENGPVLEVICSRMRYISSQIERPIRI
V
A
L
S
S
S
L
S
N
A
K
D
V
A
H
W
L
G
C
S
A
T
S
T
F
N
F
--------
H
P
N
--------
V
R
P
V
P
L
E
L
H
I
Q
G
F
-------------
N
I
S
---------------
H
T
Q
T
R
L
L
S
M
A
K
P
V
Y
H
A
I
T
K
H
S
P
K
KPVIVF
V
-----------------
P
S
R
K
Q
T
R
L
T
A
I
D
I
L
T
T
C
A
A
D
I
Q
R
Q
R
F
L
H
C
T
E
K
D
L
I
---------------
P
Y
L
E
K
L
S
D
S
T
---------
L
K
E
T
L
L
----
N
G
V
G
Y
L
H
E
G
L
-------------------------------
S
--
P
-----
M
E
R
R
L
V
E
Q
L
F
S
S
G
A
I
Q
V
V
V
A
S
R
S
L
----
C
W
G
M
N
V
A
A
H
L
V
I
I
M
D
T
Q
Y
Y
N
G
K
I
H
-
A
Y
V
D
Y
P
I
Y
D
V
L
Q
M
V
G
H
A
N
R
P
------
L
Q
D
D
E
G
R
C
V
I
M
C
Q
G
S
K
K
D
F
F
K
K
F
L
Y
E
P
L
P
V
E
SH-
L
D
H
C
M
H
D
H
F
N
A
E
I
V
T
K
T
I
E
N
K
Q
D
A
V
D
Y
L
T
----
W
T
F
L
Y
R
R
M
T
Q
N
P
N
Y
Y
N
L
Q
G
I
S
H
R
H
L
S
------
D
H
L
S
E
L
V
E
Q
T
L
S
D
L
E
Q
S
K
C
I
S
I
ED
E
M
D
--------
V
A
P
L
N
L
G
M
I
A
A
YYY
I
N
----------------
Y
T
T
I
E
L
F
S
M
S
L
N
A
K
----------------
T
K
V
R
G
L
I
E
I
I
S
N
A
A
E
Y
E
N
I
P
I
R
H
H
E
D
N
-----
L
L
R
Q
L
A
Q
K
V
P
H
K
L
N
N
P
-
K
F
N
D
--
P
H
V
K
T
N
L
L
L
Q
A
H
L
S
R
M
Q
L
----------
S
----
A
E
L
Q
S
D
T
E
E
I
L
S
K
A
I
R
L
I
Q
A
C
V
D
V
L
S
S
----
N
----------
G
W
L
S
P
A
L
A
A
-------------
M
E
L
A
Q
M
V
T
Q
A
M
W
S
K
--------------------------------------
D
-
S
-
Y
L
K
Q
-
L
------------------------------
P
H
-------------
F
----------
T
----------
S
E
----
H
I
----
K
-
R
--
C
T
D
K
-------
G
V
E
----
S
V
F
--------------
D
I
M
E
M
E
D
---
E
E
R
-------------------------------
N
A
L
L
Q
L
T
D
S
Q
I
A
-----
D
V
A
---------------
R
F
C
N
R
Y
P
N
-
I
E
L
S
Y
E
V
V
D
K
D
S
I
R
S
G
G
P
V
V
V
L
V
Q
L
E
R
E
-----------------
E
-------------------
E
----
V
-
T
----
G
P
-
V
I
A
P
---
L
-
F
P
Q
K
R
E
EGWW
V
V
I
G
-
D
AKSN
S
L
---
I
S
I
K
R
LTLQQKAKVKLDFVAPATGAHNYTLYFMSDAYMGCDQEYKFSVD
43
Fugue
48.47
11%
-36
- C7 -
3TJ1
-
RRN3_YEAST
A:
[46-617]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
F
S
A
A
M
Y
S
R
F
V
K
S
A
L
D
D
L
D
K
N
D
S
--------------------------------------
T
Q
I
G
I
I
A
N
Q
V
A
L
P
S
K
N
P
E
R
I
N
D
K
N
L
N
I
L
L
D
I
L
---------------
S
S
N
I
N
R
I
E
S
S
---------
R
G
T
F
L
I
----
Q
S
I
I
N
F
E
K
W
W
E
L
P
P
----
H
--
T
L
S
K
Y
-----------
I
Y
F
I
K
--
I
-----
L
C
S
S
I
-
P
K
W
W
Q
-
D
V
S
M
I
L
V
S
C
F
I
L
----
P
I
K
-
Q
T
V
C
H
H
D
M
L
K
Y
F
L
R
M
I
---
P
S
S
M
G
F
I
D
T
Y
L
A
K
F
F
P
N
K
N
D
T
R
------
R
K
L
V
N
Y
T
S
N
L
L
K
L
R
G
Y
C
------------------
S
E
L
G
F
Q
I
W
S
--
L
L
I
E
K
I
I
S
I
D
V
E
L
Q
N
E
L
D
E
L
D
-----------
T
Q
G
I
K
-
E
L
S
T
K
L
D
S
I
--------
L
T
L
V
S
T
H
V
E
E
Q
V
T
P
E
S
L
E
S
G
--
E
G
V
--------
G
V
F
N
T
L
--
T
T
L
---
F
K
----------------
T
H
V
L
P
T
Y
Y
T
R
S
I
Q
Y
I
M
F
H
V
S
Q
--
Q
Q
---------
L
E
L
M
D
S
F
L
V
T
L
I
D
I
S
F
A
V
N
E
A
A
E
-----
K
K
I
K
S
L
Q
Y
L
G
S
Y
I
A
R
A
K
K
L
S
R
T
Q
I
I
F
V
A
S
Y
L
T
S
W
L
N
R
Y
V
I
E
R
E
E
E
V
D
Q
R
G
G
M
----
E
R
F
K
H
F
Y
A
A
F
Q
A
L
C
Y
I
F
C
F
R
H
N
I
F
R
D
T
----
D
----------
G
N
W
-
E
C
E
L
D
-------------
K
F
F
Q
R
M
V
I
S
K
F
--
N
P
L
K
F
-------------------------------
C
N
E
N
-
V
-
M
L
M
F
-
A
------------------------------
R
I
-------------
A
----------
Q
----------
Q
E
----
S
V
----
A
-
Y
--
C
F
S
I
-------
I
E
N
----
N
N
N
--------------
E
R
L
R
G
S
S
----------------------------
W
---
S
L
A
T
R
Q
Q
F
I
D
L
Q
S
Y
------------------------------
F
P
Y
D
P
L
F
L
K
N
Y
K
I
L
M
K
E
Y
Y
I
E
W
S
E
A
S
----------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
47.96
10%
-91
- C9 -
5BV8
1
A:
[49-222]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
L
D
L
V
F
L
L
D
G
S
S
R
L
S
E
-----
A
----------
E
F
E
V
L
K
A
F
V
-------------
V
D
M
M
E
R
L
R
I
S
Q
K
W
V
R
V
A
V
-------------------------------
V
E
Y
H
-
D
-
S
S
H
A
-
Y
------------------------------
I
G
L------------
K
DRKR
P
S
E
L
R
R
I
----------
A
S
----
Q
V
----
K
-
Y
--
A
G
S
Q
-------
V
A
S
----
T
S
E
--------------
V
L
K
Y
T
L
F
---
Q
I
F
S
KID--
R
-----
P
---
E
A
S
R
I
T
L
---
L
L
M
A
S
Q
E
P
Q
R
M
S
----------------------------------------
R
N
F
V
R
Y
V
Q
G
L
K
K
K
K
V
I
V
I
P
V
G
I
G
P
H
-----------------
A
N
---------
L
K
Q
I
R
L
I
E
K
Q
----
A
P
E
----
N
K
-
A
F
V
L
---
S
S
V
D
E
L
E
---------------------------------------------------------------------