@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1058: (2016-04-28 )
MYGTMQDFPLTITAIMRHGCGVHGRRTVTTATGEGYRHSSYRDVGQRAGQLANALRRLGVTGDQRVATFMWNNTEHLVTYFAVPSMGAVLHTLNIRLFPEQIAYVTNEAEDRVILVDLSLARLLAPVLPKLDTVHTVIAVGEGDTTPLREAGKTVLRFAELIDAESPDFGWPQIDENSAAAMCYTSGTTGNPKGVVYSHRSSFLHTMAACTTNGIGVGSSDKVLPIVPMFHANGWGLPYAALMAGADLVLPDRHLDARSLIHMVETLKPTLAGAVPTIWNDVMHYLEKDPDHDMSSLRLVACGGSAVPESLMRTFEDKHDVQIRQLWGMTETSPLATMAWPPPGTPDDQHWAFRITQGQPVCGVETRIVDDDGQVLPNDGNAVGEVEVRGPWIAGSYYGGRDESKFDSGWLRTGDVGRIDEQGFITLTDRAKDVIKSGGEWISSVELENCLIAHPDVLEAAVVGVPDERWQERPLAVVVVREGATVSAGDLRAFLADKVVRWWLPERWAFVDEIPRTSVGKYDKKAIRSRYAEGAYQITEVHT
Atome Classification :
(21 SA)
---------------------------------------------------------------.........10...--.....20........30--..---.--.....40........50........60........70........80........90........100--.........110....---------.--------..120..-...---------.----.--130.-........140.......150.......160.......170.......180.......190.......200.......210..----.....220.......230....--.-.--.240.....-..-250---...-.---.----..--..260.......270.......280......-.-290--........300.......310.....---..---320.......330-----.......340.---......350.......360.-----.-.....370-........380.......390-........--400--.---..---.---...410------........420.......430.......440.......450.......460.......470.......480..---.---...---.490.-.---....-.500.......510.......520.......530.......540.-------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------------------------------------MYGTMQDF
P
L
T
I
T
A
--
I
M
R
HGCGVHG
R
R
T
V
T
TA--TG---E--GYRH
S
S
Y
R
D
V
G
Q
R
A
G
Q
L
A
N
A
L
R
RLGVTGD
Q
R
V
A
T
F
M
WNNT
E
H
L
V
T
Y
FAVP
S
M
G
A
V
L
H
T
L
N
I
R
L
F
P
E
----
Q
I
A
Y
V
TNEAED
R
V
I
L
V
---------
D
--------
L
S
L
A
R
L
L
-
A
P
V
---------L----P--K--L-D
T
V
H
T
V
I
A
VGEGDT
T
P
L
R
E
A
G
K
T
V
L
R
F
A
E
L
IDAESPDFGWPQIDENS
A
A
A
M
C
Y
TSGTTGNPK
G
V
V
Y
S
H
R
S
S
F
L
H
T
M
A
A
CTTNG----IGVGSSD
K
V
L
P
I
V
P
M
F
HANGWG--
L
-
P
--
Y
A
A
L
MAGA
D
-
L
V-L-----PDR-H---L----
D
A
--
R
S
L
I
H
M
V
E
T
L
K
P
T
LAGA
V
P
T
I
W
N
D
V
M
H
Y
LEK-D-PD---H
D
M
S
S
L
R
L
V
ACGGSA
V
P
E
S
L
M
R
T
FED---KH---
D
V
Q
I
R
Q
L
WGMTET-----SP
L
A
TMAWPPP---GTPDDQ
H
W
A
F
R
ITQGQPVCG-----
V
-
E
T
R
I
VD-D-DGQVLPNDGN
A
V
G
E
V
E
V
RG
P
--
W
I
AGSYYG--GRD--E---SK---F---DSGWL-------RTGDVGRIDEQ
G
F
I
T
L
T
D
R
A
K
D
V
I
K
SGG
E
W
I
S
S
V
ELENCLIAH
P
D
V
L
E
A
A
VVGV
P
D
E
R
WQERP
L
A
V
V
V
V
REGA---T---V
S
A
---
G
D
L
R
A
-
F
---
L
A
D
K
-
V
V
R
W
WL
P
E
R
W
A
F
V
D
EIPRTSVG
K
Y
D
K
K
A
I
R
S
R
Y
AEG
A
Y
Q
I
T
EVHT-------
1
PsiBlast_PDB
98.22
42%
-107
- C3 -
1ULT
1
LCFCS_THET8
A:
[12-534]
------------------------------------------------------------------
T
M
M
D
E
E
L
N
L
W
D
--
F
L
E
R
A
A
A
L
F
G
R
K
E
V
V
S
R
L
H
T
G
---
E
--
V
H
R
-
T
T
Y
A
E
V
Y
Q
R
A
R
R
L
M
G
G
L
R
A
L
G
V
G
V
G
D
R
V
A
T
L
G
F
N
H
F
R
H
L
E
A
Y
F
A
V
P
G
M
G
A
V
L
H
T
A
N
P
R
L
S
P
K
----
E
I
A
Y
I
L
N
H
A
E
D
K
V
L
L
F
---------
D
--------
P
N
L
L
P
L
V
-
E
A
I
---------
R
----
G
--
E
--
L
-
K
T
V
Q
H
F
V
V
M
D
E
-------
K
A
P
E
G
Y
L
A
Y
E
E
A
L
G
E
E
A
D
P
V
---
R
V
P
E
R
A
A
C
G
M
A
Y
T
T
G
T
T
G
L
P
K
G
V
V
Y
S
H
R
A
L
V
L
H
S
L
A
A
S
L
V
D
G
----
T
A
L
S
E
K
D
V
V
L
P
V
V
P
M
F
H
V
N
A
W
C
--
L
-
P
--
Y
A
A
T
L
V
G
A
K
-
Q
V
-
L
-----
P
G
P
-
R
---
L
----
D
P
--
A
S
L
V
E
L
F
D
G
E
G
V
T
F
T
A
G
V
P
T
V
W
L
A
L
A
D
Y
L
E
S
-
T
--
G
---
H
R
L
K
T
L
R
R
L
V
V
G
G
S
A
A
P
R
S
L
I
A
R
F
E
----
R
M
---
G
V
E
V
R
Q
G
Y
G
L
T
E
T
-----
S
P
V
V
V
Q
N
F
V
K
S
HLE
S
L
S
E
E
E
K
L
T
L
K
A
K
T
G
L
P
I
P
L
-----
V
-
R
L
R
V
A
D
-
E
-
E
G
R
P
V
P
K
D
G
K
A
L
G
E
V
Q
L
K
G
P
--
W
I
T
G
G
Y
Y
G
--
N
E
E
--
A
---
T
R
S
AL
T
---
P
D
G
F
F
-------
R
T
G
D
I
A
V
W
D
E
E
G
Y
V
E
I
K
D
R
L
K
D
L
I
K
S
G
G
E
W
I
S
S
V
D
L
E
N
A
L
M
G
H
P
K
V
K
E
A
A
V
V
A
I
P
H
P
K
W
Q
E
R
P
L
A
V
V
V
P
R
-
G
E
---
K
---
P
T
P
---
E
E
L
N
E
H
L
---
L
K
A
G
-
F
A
K
W
Q
L
P
D
A
Y
V
F
A
E
E
I
P
R
T
S
A
G
K
F
L
K
R
A
L
R
E
Q
Y
-------------------
21
PsiBlast_CBE
95.40
42%
-100
- C3 -
1V25
2
LCFCS_THET8
B:
[12-534]
------------------------------------------------------------------
T
M
M
D
E
E
L
N
L
W
D
--
F
L
E
R
A
A
A
L
F
G
R
K
E
V
V
S
R
LH
T
G
---
E
--
V
H
R
-
T
T
Y
A
E
V
Y
Q
R
A
R
R
L
M
G
G
L
R
A
L
G
V
G
V
G
D
R
V
A
T
L
G
F
N
H
F
R
H
L
E
A
Y
F
A
V
P
G
M
G
A
V
L
H
T
A
N
P
R
L
S
P
K
----
E
I
A
Y
I
L
N
H
A
E
D
K
V
L
L
F
---------
D
--------
P
N
L
L
P
L
V
-
E
A
I
---------
R
----
G
--
E
--
L
-
K
T
V
Q
H
F
V
V
M
D
E
-------
K
A
P
E
G
Y
L
A
Y
E
E
A
L
G
E
E
A
D
P
V
---
R
V
P
E
R
A
A
C
G
M
A
Y
T
T
G
T
T
G
L
P
K
G
V
V
Y
S
H
R
A
L
V
L
H
S
L
A
A
S
L
V
D
G
----
T
A
L
S
E
K
D
V
V
L
P
V
V
P
M
F
H
V
N
A
W
C
--
L
-
P
--
Y
A
A
T
L
V
G
A
K
-
Q
V
-
L
-----
P
G
P
-
R
---
L
----
D
P
--
A
S
L
V
E
L
F
D
G
E
G
V
T
F
T
A
G
V
P
T
V
W
L
A
L
A
D
Y
L
E
S
-
T
--
G
---
H
R
L
K
T
L
R
R
L
V
V
G
G
S
A
A
P
R
S
L
I
A
R
F
E
----
R
M
---
G
V
E
V
R
Q
G
Y
G
L
T
E
T
-----
S
P
V
V
V
Q
N
F
V
K
S
HLE
S
L
S
E
E
E
K
L
T
L
K
A
K
T
G
L
P
I
P
L
-----
V
-
R
L
R
V
A
D
-
E
-
E
G
R
P
V
P
K
D
G
K
A
L
G
E
V
Q
L
K
G
P
--
W
I
T
G
G
Y
Y
G
--
N
E
E
--
A
---
T
R
SAL
T
---
P
D
G
F
F
-------
R
T
G
D
I
A
V
W
D
E
E
G
Y
V
E
I
K
D
R
L
K
D
L
I
K
S
G
G
E
W
I
S
S
V
D
L
E
N
A
L
M
G
H
-----
A
A
V
V
A
I
P
H
P
K
W
Q
E
R
P
L
A
V
-----------------------
N
E
H
L
---
L
K
A
G
-
F
A
K
W
Q
L
P
D
A
Y
V
F
---------
G
K
F
L
K
R
A
L
R
E
Q
Y
-------------------
48
HHSearch
83.23
28%
-96
- C3 -
1MDB
4
DHBE_BACSU
A:
[26-534]
-------------------------------------------------------------------------
T
F
G
D
--
L
L
R
D
R
A
A
K
Y
G
D
R
I
A
I
T
C
--
G
--------
N
T
H
W
S
Y
R
E
L
D
T
R
A
D
R
L
A
A
G
F
Q
K
L
G
I
Q
Q
K
D
R
V
V
V
Q
L
P
N
I
K
E
F
F
E
V
I
F
A
L
F
R
L
G
A
L
P
V
F
A
L
P
S
H
R
S
S
----
E
I
T
Y
F
C
E
F
A
E
A
A
A
Y
I
I
---------
P
--------
D
A
Y
S
G
F
D
Y
R
S
L
---------
A
R
Q
V
Q
S
--
K
--
L
-
P
T
L
K
N
I
I
V
A
G
E
A
---------
E
E
F
L
P
L
E
D
L
H
T
---
E
P
V
K
L
P
E
V
K
S
S
D
V
A
F
L
Q
L
S
G
G
S
T
G
L
S
K
L
I
P
R
T
H
D
D
Y
I
Y
S
L
K
R
S
--
V
E
V
----
C
W
L
D
H
S
T
V
Y
L
A
A
L
P
M
A
H
N
Y
P
L
S
SP
G
-
V
--
L
G
V
L
Y
A
G
G
R
-
V
V
-
L
-----
S
P
S
-----
P
----
S
P
--
D
D
A
F
P
L
I
E
R
E
K
V
T
I
T
A
L
V
P
P
L
A
M
V
W
M
D
A
A
S
S
-
R
-
R
D
----
D
L
S
S
L
Q
V
L
Q
V
G
G
A
K
F
S
A
E
A
A
R
R
V
K
A
---
V
F
---
G
C
T
L
Q
Q
V
F
G
M
A
E
G
-----
L
V
N
Y
T
R
L
D
D
P
----------
E
E
I
I
V
N
T
Q
G
K
P
M
S
P
Y----
D
-
E
S
R
V
W
D
-
D
-
H
D
R
D
V
K
P
--
G
E
T
G
H
L
L
T
R
G
P
--
Y
T
I
R
G
Y
Y
K
--
A
E
E
H
N
A
---
A
S
---
F
T--
E
D
G
F
Y
-------
R
T
G
D
I
V
R
L
T
R
D
G
Y
I
V
V
E
G
R
A
K
D
Q
I
N
R
G
G
E
K
V
A
A
E
E
V
E
N
H
L
L
A
H
P
A
V
H
D
A
A
M
V
S
M
P
D
Q
F
L
G
E
R
S
C
V
F
I
I
P
R
D
E
----
A
---
P
K
A
---
A
E
L
K
A
-
F
---
L
R
E
R
G
L
A
A
Y
K
I
P
D
R
V
E
F
V
E
S
F
P
Q
T
G
V
G
K
V
S
K
K
A
L
R
E
A
I
S
E
K
L
L
--------------
15
PsiBlast_PDB
80.13
28%
-103
- C3 -
3A9V
1
?
A:
[42-532]
--------------------------------------------------------------------------------------------
I
N
G
A
--
N
G
---
D
--
V
Y
---
T
Y
A
D
V
E
L
T
A
R
R
V
A
S
G
L
N
K
I
G
I
Q
Q
G
D
V
I
M
L
F
L
P
S
S
P
E
F
V
L
A
F
L
G
A
S
H
R
G
A
I
I
T
A
A
N
P
F
S
T
P
A
----
E
L
A
K
H
A
K
A
S
R
A
K
L
L
I
T
---------
Q
--------
A
C
Y
Y
E
K
V
-
K
D
F
---------
A
----
R
--
E
--
S
-
D
V
--
K
V
M
C
V
---
D
S
A
P
-----
D
G
C
L
H
F
S
E
L
T
Q
A
D
E
N
E
A
P
Q
V
D
I
S
P
D
D
V
V
A
L
P
Y
S
S
G
T
T
G
L
P
K
G
V
M
L
T
H
K
G
--
L
I
T
S
V
A
Q
Q
V
D
G
DNPN
L
Y
F
H
S
E
D
V
I
L
C
V
L
P
M
F
H
I
Y
A
L
N
S-
I
-
M
--
L
C
G
L
R
V
G
A
P
I
L
I
-
M
-----
P
---
K
---
F
----
E
I
--
G
S
L
L
G
L
I
E
K
Y
K
V
S
I
A
P
V
V
P
P
----
V
M
M
S
I
A
K
-
S
-
P
D
LDK
H
D
L
S
S
L
R
M
I
K
S
G
G
A
P
L
G
K
E
L
E
D
T
V
R
A
---
K
F
P--
Q
A
R
L
G
Q
G
Y
G
M
T
E
A
-----
G
P
V
L
A
M
C
L
A
F
A
---
K
E
P
------
F
D
I
K
P
G
--
A
C
G
TVVRN
A
-
E
M
K
I
V
D
P
E
-
T
G
A
S
L
P
R
--
N
Q
P
G
E
I
C
I
R
G
D
--
Q
I
M
K
G
Y
L
N
--
D
P
E
--
A
---
T
S
---
R
T
I
D
K
E
G
W
L
-------
H
T
G
D
I
G
Y
I
D
D
D
D
E
L
F
I
V
D
R
L
K
E
L
I
K
Y
K
G
F
Q
V
A
P
A
E
L
E
A
L
L
I
A
H
P
E
I
S
D
A
A
V
V
G
L
K
D
E
D
A
G
E
V
P
V
A
F
V
V
K
S
E
K
S
---
Q
---
A
T
E
---
D
E
I
K
Q
-
Y
---
I
S
K
Q
-
V
I
F
Y
K
R
I
K
R
V
F
F
I
E
A
I
P
K
A
P
S
G
K
I
L
R
K
N
L
K
E
K
--------------------
2
PsiBlast_PDB
80.04
27%
-95
- C3 -
4WV3
1
?
A:
[5-514]
---------------------------------------------------------------------
D
L
P
L
Y
Y
N
A
VD
I
L
E
R
N
L
P
V
R
A
N
K
T
A
L
F
T
--
P
D
--------
R
E
M
T
F
R
Q
V
S
N
E
A
N
Q
V
G
N
A
L
K
G
L
G
V
R
F
G
E
C
V
G
L
L
T
L
D
S
A
E
W
V
T
S
F
F
G
I
V
K
L
G
A
I
A
V
G
I
N
T
L
L
K
P
P
----
E
Y
E
Y
I
L
R
D
C
R
A
R
V
L
I
V
---------
H
--------
Q
E
F
L
P
L
I
-
E
S
I
---------
R
----
G
--
N
--
L
-
P
M
L
E
H
I
V
V
I
G
------------
G
Y
L
S
F
N
D
W
I
R
P
Q
P
T
T
L
E
A
A
Q
S
H
R
E
D
I
C
S
L
N
Y
S
S
G
-
T
G
G
P
K
G
I
P
H
A
H
K
D
Y
P
L
-
T
A
Q
L
W
G
V
N
V
----
L
G
L
R
E
S
D
R
T
F
A
L
A
K
L
F
F
T
F
G
T
G
G
N
L
-
I
--
F
P
W
Y
V
G
A
S
C
-
V
L
-
F
-----
P
G
A
-
A
---
R
----
V
A
--
S
N
V
L
S
T
I
S
R
F
K
P
T
I
F
Y
N
A
P
T
G
Y
A
A
A
L
A
-
L
K
D
-
F
-
S
Q
---
H
D
L
S
S
L
R
L
C
V
S
A
S
E
A
L
P
A
A
L
W
Y
A
W
K
E
---
A
T
---
G
V
D
I
I
D
G
I
G
C
T
E
N
-----
F
H
I
F
I
S
N
R
P
G
D
---
I
R
P
G
--------
S
S
G
K
P
V
E
G
-----
Y
-
E
L
K
L
V
D
-
D
-
E
G
K
T
V
P
--
A
G
E
I
G
N
V
L
L
R
S
E
--
T
A
A
L
S
Y
W
H
--
N
F
E
--
K
---
S
R
Q
T
-
F
---
Q
G
E
W
L
-------
A
T
G
D
K
Y
F
V
D
A
D
G
Y
Y
W
H
A
G
R
S
D
D
M
L
K
V
G
G
I
W
V
S
P
V
E
V
E
S
T
L
I
Q
H
P
A
V
Q
E
C
A
V
I
G
C
P
D
Q
S
R
L
I
K
P
K
A
F
I
I
L
K
P
E
Q
---
I
---
P
S
E
---
A
L
I
R
Q
-
I
T
D
H
C
T
E
K
-
M
A
A
Y
K
R
P
R
W
I
E
F
V
T
E
L
P
K
T
A
T
G
K
I
Q
R
F
K
L
R
S
---------------------
16
PsiBlast_PDB
80.02
28%
-102
- C3 -
3NI2
4
?
A:
[42-532]
--------------------------------------------------------------------------------------------
I
N
G
A
--
N
G
---
D
--
V
Y
---
T
Y
A
D
V
E
L
T
A
R
R
V
A
S
G
L
N
K
I
G
I
Q
Q
G
D
V
I
M
L
F
L
P
S
S
P
E
F
V
L
A
F
L
G
A
S
H
R
G
A
I
I
T
A
A
N
P
F
S
T
P
A
----
E
L
A
K
H
A
K
A
S
R
A
K
L
L
I
T
---------
Q
--------
A
C
Y
Y
E
K
V
-
K
D
F
---------
A
----
R
--
E
--
S
-
D
V
--
K
V
M
C
V
---
D
S
A
P
-----
D
G
C
L
H
F
S
E
L
T
Q
A
D
E
N
E
A
P
Q
V
D
I
S
P
D
D
V
V
A
L
P
Y
S
S
G
T
T
G
L
P
K
G
V
M
L
T
H
K
G
--
L
I
T
S
V
A
Q
Q
V
D
G
DNPN
L
Y
F
H
S
E
D
V
I
L
C
V
L
P
M
F
H
I
Y
A
L
N
S-
I
-
M
--
L
C
G
L
R
V
G
A
P
I
L
I
-
M
-----
P
---
K
---
F
----
E
I
--
G
S
L
L
G
L
I
E
K
Y
K
V
S
I
A
P
V
V
P
P
----
V
M
M
S
I
A
K
-
S
-
P
D
LDK
H
D
L
S
S
L
R
M
I
K
S
G
G
A
P
L
G
K
E
L
E
D
T
V
R
A
---
K
F
P--
Q
A
R
L
G
Q
G
Y
G
M
T
E
A
-----
G
P
V
L
A
M
C
L
A
F
A
---
K
E
P
------
F
D
I
K
P
G
--
A
C
G
TVVRN
A
-
E
M
K
I
V
D
P
E
-
T
G
A
S
L
P
R
--
N
Q
P
G
E
I
C
I
R
G
D
--
Q
I
M
K
G
Y
L
N
--
D
P
E
--
A
---
T
S
---
R
T
I
D
K
E
G
W
L
-------
H
T
G
D
I
G
Y
I
D
D
D
D
E
L
F
I
V
D
R
L
K
E
L
I
K
Y
K
G
F
Q
V
A
P
A
E
L
E
A
L
L
I
A
H
P
E
I
S
D
A
A
V
V
G
L
K
D
E
D
A
G
E
V
P
V
A
F
V
V
K
S
E
K
S
---
Q
---
A
T
E
---
D
E
I
K
Q
-
Y
---
I
S
K
Q
-
V
I
F
Y
K
R
I
K
R
V
F
F
I
E
A
I
P
K
A
P
S
G
K
I
L
R
K
N
L
K
E
K
--------------------
18
PsiBlast_PDB
79.15
28%
-82
- C3 -
1MDB
4
DHBE_BACSU
A:
[26-531]
-------------------------------------------------------------------------
T
F
G
D
--
L
L
R
D
R
A
A
K
Y
G
D
R
I
A
I
T
C
----------
G
N
T
H
W
S
Y
R
E
L
D
T
R
A
D
R
L
A
A
G
F
Q
K
L
G
I
Q
Q
K
D
R
V
V
V
Q
L
P
N
I
K
E
F
F
E
V
I
F
A
L
F
R
L
G
A
----
L
P
V
F
A
L
P
S
HR
S
S
E
I
T
Y
F
C
E
F
A
E
A
A
A
Y
I
I
---------
P
DAYSGFD
Y
R
S
L
A
R
----
Q
V
---------
Q
----
S
--
K
--
L
-
P
T
L
K
N
I
I
V
A
G
E
A
E
------------
E
F
L
P
L
E
D
L
H
T
E
P
V
K
L
P
E
V
K
S
S
D
V
A
F
L
Q
L
S
G
G
S
T
G
L
S
K
L
I
P
R
T
H
-
D
D
Y
I
Y
S
L
K
R
-
S
V
E
V
----
C
W
L
D
H
S
T
V
Y
L
A
A
L
P
M
A
H
N
Y
P
L
S
--
S
-
P
G
V
L
G
V
L
Y
A
G
G
R
-
V
V
-
L
S
PSPS
P
D
-----------
D
A
--
F
P
L
I
E
R
E
K
V
T
I
T
A
L
V
P
P
L
A
M
V
W
M
D
A
A
S
S
-
R
R
-
D
-------
D
L
S
S
L
Q
V
L
Q
V
G
G
A
K
F
S
A
E
A
A
R
R
V
K
A
---
V
F
---
G
C
T
L
Q
Q
V
F
G
M
A
E
G
-----
L
V
N
Y
T
R
L
----------
D
D
P
E
E
I
I
V
N
T
Q
G
K
P
M
S
P
-----
Y
D
E
S
R
V
W
D
-
D
H
D
R
D
V
K
P
G
E
---
T
G
H
L
L
T
R
G
P
--
Y
T
I
R
G
Y
Y
K
--
A
E
E
--
H
N
A
A
S
F
---
T
---
E
D
G
F
Y
-------
R
T
G
D
I
V
R
L
T
R
D
G
Y
I
V
V
E
G
R
A
K
D
Q
I
N
R
G
G
E
K
V
A
A
E
E
V
E
N
H
L
L
A
H
P
A
V
H
D
A
A
M
V
S
M
P
D
Q
F
L
G
E
R
S
C
V
F
I
I
P
R
D
E
A
---
P
----
K
A
---
A
E
L
K
A
-
F
---
L
R
E
R
G
L
A
A
Y
K
I
P
D
R
V
E
F
V
E
S
F
P
Q
T
G
V
G
K
V
S
K
K
A
L
R
E
A
I
S
E
-----------------
47
HHSearch
78.74
27%
-95
- C3 -
3R44
2
FAC13_MYCTU
A:
[13-514]
---------------------------------------------------------------------
D
K
M
K
N
I
G
W
--
M
L
R
Q
R
A
T
V
S
P
R
L
Q
A
Y
V
E
--
P
S
---
T
---
D
V
R
M
T
Y
A
Q
M
N
A
L
A
N
R
C
A
D
V
L
T
A
L
G
I
A
K
G
D
R
V
A
L
L
M
P
N
S
V
E
F
C
C
L
F
Y
G
A
A
K
L
G
A
V
A
V
P
I
N
T
R
L
A
A
P
----
E
V
S
F
I
L
S
D
S
G
S
K
V
V
I
Y
---------
G
--------
A
P
S
A
P
V
I
-
D
A
I
---------
R
----
A
--
Q
--
A
-
D
P
P
G
T
V
T
--
D
W
----------
I
G
A
D
S
L
A
E
R
L
R
S
A
A
A
D
E
P
A
V
E
C
G
G
D
D
N
L
F
I
M
Y
T
S
---
G
H
P
K
G
V
V
H
T
H
E
S
V
H
S
A
A
S
S
W
--
A
S
T
----
I
D
V
R
Y
R
D
R
L
L
L
P
L
P
M
F
H
V
A
A
L
T
--
T
-
V
--
I
F
S
A
M
R
G
V
T
-
L
I
-
S
-----
M
P
Q
-----
F
----
D
A
--
T
K
V
W
S
L
I
V
E
E
R
V
C
I
G
G
A
V
P
A
I
L
N
F
M
R
Q
V
P
E
F
-
A
-
E
L
----
D
A
P
D
F
R
Y
F
I
T
G
G
A
P
M
P
E
A
L
I
K
I
Y
A
A
----
K
---
N
I
E
V
V
Q
G
Y
A
L
T
E
S
-----
C
G
G
G
T
L
L
L
S
E
D
---------
A
L
R
K
A
G
S
A
G
R
A
T
M
F
-----
T
-
D
V
A
V
R
G
-
D
-
D
G
V
I
R
E
H
---
G
E
G
E
V
V
I
K
S
D
--
I
L
L
K
E
Y
W
N
--
R
P
E
A
T
R
---
D
A
---
F
---
D
N
G
W
F
-------
R
T
G
D
I
G
E
I
D
D
E
G
Y
L
Y
I
K
D
R
L
K
D
M
I
I
S
G
G
E
N
V
Y
P
A
E
I
E
S
V
I
I
G
V
P
G
V
S
E
V
A
V
I
G
L
P
D
E
K
W
G
E
I
A
A
A
I
V
V
A
D
Q
N
----
E
---
V
S
E
---
Q
Q
I
V
E
-
Y
---
C
G
T
R
-
L
A
R
Y
K
L
P
K
K
V
I
F
A
E
A
I
P
R
N
P
T
G
K
I
L
K
T
V
L
R
E
Q
Y
S
A
T
----------------
3
PsiBlast_PDB
78.36
28%
-100
- C3 -
3R44
2
FAC13_MYCTU
A:
[45-512]
---------------------------------------------------------------------------------------------------------------
T
Y
A
Q
M
N
A
L
A
N
R
C
A
D
V
L
T
A
L
G
I
A
K
G
D
R
V
A
L
L
M
P
N
S
V
E
F
C
C
L
F
Y
G
A
A
K
L
G
A
V
A
V
P
I
N
T
R
L
A
A
P
----
E
V
S
F
I
L
S
D
S
G
S
K
V
V
I
Y
---------
G
--------
A
P
S
A
P
V
I
-
D
A
I
---------
R
----
A
--
Q
--
A
-
D
P
P
G
T
V
T
D
W
I
G
A
D
S
------------
L
A
E
R
L
R
S
A
A
A
D
E
P
A
V
E
C
G
G
D
D
N
L
F
I
M
Y
T
S
---
G
H
P
K
G
V
V
H
T
H
E
S
--
V
H
S
A
A
S
S
W
A
S
T
----
I
D
V
R
Y
R
D
R
L
L
L
P
L
P
M
F
H
V
A
A
L
T
--
T
-
V
--
I
F
S
A
M
R
G
V
T
-
L
I
S
M
-----
P
---
Q
---
F
----
D
A
--
T
K
V
W
S
L
I
V
E
E
R
V
C
I
G
G
A
V
P
A
I
L
N
-
F
M
R
Q
V
P
E
-
F
-
A
E
---
L
D
A
P
D
F
R
Y
F
I
T
G
G
A
P
M
P
E
A
L
I
K
I
Y
A
A
---
K
----
N
I
E
V
V
Q
G
Y
A
L
T
E
S
-----
C
G
G
G
T
L
L
L
-------
S
E
D
A
L
R
K
A
G
--
S
A
G
R
A
T
M
F
-----
T
-
D
V
A
V
R
G
-
D
-
D
G
-
V
I
R
E
H
G
E
--
G
E
V
V
I
K
S
D
--
I
L
L
K
E
Y
W
N
--
R
P
E
--
A
---
T
R
D
A
-
F
---
D
N
G
W
F
-------
R
T
G
D
I
G
E
I
D
D
E
G
Y
L
Y
I
K
D
R
L
K
D
M
I
I
S
G
G
E
N
V
Y
P
A
E
I
E
S
V
I
I
G
V
P
G
V
S
E
V
A
V
I
G
L
P
D
E
K
W
G
E
I
A
A
A
I
V
V
A
D
Q
N
----
E
---
V
S
E
---
Q
Q
I
V
E
-
Y
---
C
G
T
R
-
L
A
R
Y
K
L
P
K
K
V
I
F
A
E
A
I
P
R
N
P
T
G
K
I
L
K
T
V
L
R
E
Q
Y
S
------------------
19
PsiBlast_PDB
78.32
28%
-80
- C3 -
1MDF
2
DHBE_BACSU
A:
[26-531]
-------------------------------------------------------------------------
T
F
G
D
--
L
L
R
D
R
A
A
K
Y
G
D
R
I
A
I
T
C
----------
G
N
T
H
W
S
Y
R
E
L
D
T
R
A
D
R
L
A
A
G
F
Q
K
L
G
I
Q
Q
K
D
R
V
V
V
Q
L
P
N
I
K
E
F
F
E
V
I
F
A
L
F
R
L
G
A
----
L
P
V
F
A
L
P
S
HR
S
S
E
I
T
Y
F
C
E
F
A
E
A
A
A
Y
I
I
---------
P
DAYSGFD
Y
R
S
L
A
R
----
Q
V
---------
Q
----
S
--
K
--
L
-
P
T
L
K
N
I
I
V
A
G
E
A
E
------------
E
F
L
P
L
E
D
L
H
T
E
P
V
K
L
P
E
V
K
S
S
D
V
A
F
L
Q
L
S
G
G
S
T
G
L
S
K
L
I
P
R
T
H
-
D
D
Y
I
Y
S
L
K
R
-
S
V
E
V
----
C
W
L
D
H
S
T
V
Y
L
A
A
L
P
M
A
H
N
Y
P
L
S
--
S
-
P
G
V
L
G
V
L
Y
A
G
G
R
-
V
V
-
L
S
PSPS
P
D
-----------
D
A
--
F
P
L
I
E
R
E
K
V
T
I
T
A
L
V
P
P
L
A
M
V
W
M
D
A
A
S
S
-
R
R
-
D
-------
D
L
S
S
L
Q
V
L
Q
V
G
G
A
K
F
S
A
E
A
A
R
R
V
K
A
---
V
F
---
G
C
T
L
Q
Q
V
F
G
M
A
E
G
-----
L
V
N
Y
T
R
L
----------
D
D
P
E
E
I
I
V
N
T
Q
G
K
P
M
S
P
-----
Y
D
E
S
R
V
W
D
-
D
H
D
R
D
V
K
P
G
E
---
T
G
H
L
L
T
R
G
P
--
Y
T
I
R
G
Y
Y
K
--
A
E
E
--
H
N
A
A
S
F
---
T
---
E
D
G
F
Y
-------
R
T
G
D
I
V
R
L
T
R
D
G
Y
I
V
V
E
G
R
A
K
D
Q
I
N
R
G
G
E
K
V
A
A
E
E
V
E
N
H
L
L
A
H
P
A
V
H
D
A
A
M
V
S
M
P
D
Q
F
L
G
E
R
S
C
V
F
I
I
P
R
D
E
A
---
P
----
K
A
---
A
E
L
K
A
-
F
---
L
R
E
R
G
L
A
A
Y
K
I
P
D
R
V
E
F
V
E
S
F
P
Q
T
G
V
G
K
V
S
K
K
A
L
R
E
A
I
S
E
-----------------
51
Fugue
78.13
23%
-86
- C3 -
1PG4
7
ACSA_SALTY
A:
[5-647]
HKHAIP
A
N
I
A
D
RCLIN
P
E
Q
Y
E
T
K
Y
K
Q
S
I
N
D
P
D
T
F
W
G
E
Q
G
KILDWITPYQK
V
K
N
T
S
FAPG
N
V
S
I
K
W
Y
E
D
G
T
L
N
L
A
A
N
C
--
L
D
R
H
L
Q
E
N
G
D
R
T
A
I
I
W
E
--
G
D
---
D
TS
Q
S
K
H
I
S
Y
R
E
L
H
R
D
V
C
R
F
A
N
T
L
L
D
L
G
I
K
K
G
D
V
V
A
I
Y
M
P
M
V
P
E
A
A
V
A
M
L
A
C
A
R
I
G
A
V
H
S
V
I
F
G
G
F
S
P
E
----
A
V
A
G
C
I
I
D
S
S
S
R
L
V
I
T
A
D
E
G
V
R
AG
R
S
--------
I
P
L
K
K
N
V
-
D
D
A
---------
L
----
K
NP
N
--
V
-
T
S
V
E
H
V
I
V
L
K
R
T
G
S
D
I
D
W
Q
E
G
R
D
L
W
-
W
R
D
L
I
E
K
A
S
P
E
H
Q
P
E
A
M
N
A
E
D
P
L
F
I
L
Y
T
S
G
S
T
G
K
P
K
G
V
L
H
T
T
-
G
G
Y
L
V
Y
A
A
T
T
F
K
Y
V
----
F
D
Y
H
P
G
D
I
Y
W
C
T
A
D
V
G
W
V
T
G
H
S
Y-
L
-
L
--
Y
G
P
L
A
C
G
A
T
-
T
L
-
M
F
EG--
V
P
N
-
W
---
P
----
T
P
--
A
R
M
C
Q
V
V
D
K
H
Q
V
N
I
L
Y
T
A
P
T
A
I
R
A
L
M
A
E
G
D
K
A
I
-
E
G
---
T
D
R
S
S
L
R
I
L
G
S
V
G
E
P
I
N
P
E
A
W
E
W
Y
W
K
KIG
K
E
---
K
C
P
V
V
D
T
W
W
Q
T
E
T
GGFM
I
T
P
L
P
G
A
I
E
L
K
A
---
G
S
A
-----------
T
R
P
F
F
G
-----
V
-
Q
P
A
L
V
D
-
N
-
E
G
H
--
P
Q
E
G
A
T
E
G
N
L
V
I
T
D
S
--
W
P
G
Q
A
R
T
L
--
F
G
D
--
H
---
E
R
---
F
---
E
Q
T
Y
F
STFKNMY
F
S
G
D
G
A
R
R
D
E
D
G
Y
Y
W
I
T
G
R
V
D
D
V
L
N
V
S
G
H
R
L
G
T
A
E
I
E
S
A
L
V
A
H
P
K
I
A
E
A
A
V
V
G
I
P
H
A
I
K
G
Q
A
I
Y
A
Y
V
T
L
N
H
G
E
---
E
---
P
S
P
E
L
Y
A
E
V
R
N
-
W
---
V
R
K
E
-
I
G
P
L
A
T
P
D
V
L
H
W
T
D
S
L
P
K
T
R
S
G
K
I
M
R
R
I
L
R
-
K
I
A
A
G
D
A
D
P
G
V
V
E
K
L
L
E
E
K
Q
A
34
HHSearch
77.41
27%
-95
- C3 -
4WV3
1
?
A:
[9-519]
-----------------------------------------------------------------------
Y
Y
N
A
V
D
--
I
L
E
R
N
L
P
V
R
A
N
K
T
A
L
F
T
--
P
--------
D
R
E
M
T
F
R
Q
V
S
N
E
A
N
Q
V
G
N
A
L
K
G
L
G
V
R
F
G
E
C
V
G
L
L
T
L
D
S
A
E
W
V
T
S
F
F
G
I
V
K
L
G
A
I
A
V
G
I
N
T
L
L
K
P
P
----
E
Y
E
Y
I
L
R
D
C
R
A
R
V
L
I
V
---------
H
--------
Q
E
F
L
P
L
I
-
E
S
I
---------
R
----
G
--
N
--
L
-
P
M
L
E
H
I
V
V
I
G
------------
G
Y
L
S
F
N
D
W
I
R
P
Q
P
T
T
L
E
A
A
Q
S
H
R
E
D
I
C
S
L
N
Y
S
S
G
-
T
G
G
P
K
G
I
P
H
A
H
K
D
Y
P
L
T
A
Q
L
W
-
G
V
N
V
----
L
G
L
R
E
S
D
R
T
F
A
L
A
K
L
F
F
T
F
G
T
G
G
-
N
-
L
--
I
F
P
W
Y
V
G
A
S
-
C
V
-
L
-----
F
P
G
A
A
---
R
----
V
A
--
S
N
V
L
S
T
I
S
R
F
K
P
T
I
F
Y
N
A
P
T
G
Y
A
A
A
L
A
L
K
D
F
-
S
-
Q
----
H
D
L
S
S
L
R
L
C
V
S
A
S
E
A
L
P
A
A
L
W
Y
A
W
K
E
---
A
T
---
G
V
D
I
I
D
G
I
G
C
T
E
N
-----
F
H
I
F
I
S
N
R
P
G
-----------
D
I
R
P
G
S
S
G
K
P
V
E
G
-----
Y
-
E
L
K
L
V
D
-
D
-
E
G
K
T
V
P
A
--
G
E
I
G
N
V
L
L
R
S
E
--
T
A
A
L
S
Y
W
H
--
N
F
E
K
S
R
---
Q
T
---
F
---
Q
G
E
W
L
-------
A
T
G
D
K
Y
F
V
D
A
D
G
Y
Y
W
H
A
G
R
S
D
D
M
L
K
V
G
G
I
W
V
S
P
V
E
V
E
S
T
L
I
Q
H
P
A
V
Q
E
C
A
V
I
G
C
P
D
Q
S
R
L
I
K
P
K
A
F
I
I
L
K
P
E
Q
I
P
S
E
---
A
L
I
---
R
Q
I
T
D
-
H
---
C
T
E
K
-
M
A
A
Y
K
R
P
R
W
I
E
F
V
T
E
L
P
K
T
A
T
G
K
I
Q
R
F
K
L
R
S
A
A
K
L
A
----------------
24
HHSearch
77.19
23%
-83
- C3 -
1PG4
7
ACSA_SALTY
A:
[79-632]
---------------------------------------------------------------------------
A
N
--
C
L
D
R
H
L
Q
E
N
G
D
R
T
A
I
I
W
--
E
G
DDT
S
--
Q
S
K
H
I
S
Y
R
E
L
H
R
D
V
C
R
F
A
N
T
L
L
D
L
G
I
K
K
G
D
V
V
A
I
Y
M
P
M
V
P
E
A
A
V
A
M
L
A
C
A
R
I
G
A
V
H
S
V
I
F
G
G
F
S
P
E
----
A
V
A
G
C
I
I
D
S
S
S
R
L
V
I
T
---------
A
--------
D
E
G
V
R
A
G
-
R
S
I
P
L
K
K
N
V
D
D
A
L
----
K
--
N
PN
V
-
T
S
V
E
H
V
I
V
L
K
R
T
G
S
D
I
D
W
-
Q
E
G
R
D
L
W
W
R
D
L
I
E
K
A
S
P
E
H
Q
P
E
A
M
N
A
E
D
P
L
F
I
L
Y
T
S
G
S
T
G
K
P
K
G
V
L
H
T
T
G
G
Y
L
V
Y
A
A
T
T
F
-
K
Y
V
----
F
D
Y
H
P
G
D
I
Y
W
C
T
A
D
V
G
W
V
T
G
H
S
Y-
L
-
L
--
Y
G
P
L
A
C
G
A
T
-
T
L
-
M
-----
F
E
G
-
V
PNW
P
----
T
P
--
A
R
M
C
Q
V
V
D
K
H
Q
V
N
I
L
Y
T
A
P
T
A
I
R
A
L
M
A
E
G
D
K
-
A
I
E
G
---
T
D
R
S
S
L
R
I
L
G
S
V
G
E
P
I
N
P
E
A
W
E
W
Y
W
K
---
K
I
GKE
K
C
P
V
V
D
T
W
W
Q
T
E
T
-----
G
G
F
M
I
T
P
L
P
G
---------
A
I
E
L
K
A
G
S
A
T
R
P
F
F
G
-----
V
-
Q
P
A
L
V
D
-
N
-
E
G
H
P
Q
E
G
--
A
T
E
G
N
L
V
I
T
D
S
WP
G
Q
A
R
T
L
F
G
--
D
H
E
--
R
F
E
-
Q
T
Y--
F
ST-
F
K
N
M
Y
-------
F
S
G
D
G
A
R
R
D
E
D
G
Y
Y
W
I
T
G
R
V
D
D
V
L
N
V
S
G
H
R
L
G
T
A
E
I
E
S
A
L
V
A
H
P
K
I
A
E
A
A
V
V
G
I
P
H
A
I
K
G
Q
A
I
Y
A
Y
V
T
L
N
H
G
E
---
E
P
S
P
E
L
Y
---
A
E
V
R
N
-
W
---
V
R
K
E
-
I
G
P
L
A
T
P
D
V
L
H
W
T
D
S
L
P
K
T
R
S
G
K
I
M
R
R
I
L
R
K
I
A
A
G
D
----------------
14
PsiBlast_PDB
77.18
28%
-104
- C3 -
3A9U
-
?
A:
[42-534]
--------------------------------------------------------------------------------------------
I
N
G
A
--
N
G
---
D
--
V
Y
---
T
Y
A
D
V
E
L
T
A
R
R
V
A
S
G
L
N
K
I
G
I
Q
Q
G
D
V
I
M
L
F
L
P
S
S
P
E
F
V
L
A
F
L
G
A
S
H
R
G
A
I
I
T
A
A
N
P
F
S
T
P
A
----
E
L
A
K
H
A
K
A
S
R
A
K
L
L
I
T
---------
Q
--------
A
C
Y
Y
E
K
V
-
K
D
F
---------
A
----
R
--
E
----
D
V
--
K
V
M
C
V
---
D
S
A
P
-----
D
G
C
L
H
F
S
E
L
T
Q
A
D
E
N
E
A
P
Q
V
D
I
S
P
D
D
V
V
A
L
P
Y
S
S
G
T
T
G
L
P
K
G
V
M
L
T
H
K
G
--
L
I
T
S
V
A
Q
Q
V
D
G
DNPN
L
Y
F
H
S
E
D
V
I
L
C
V
L
P
M
F
H
I
Y
A
L
N
S-
I
-
M
--
L
C
G
L
R
V
G
A
P
I
L
I
-
M
-----
P
---
K
---
F
----
E
I
--
G
S
L
L
G
L
I
E
K
Y
K
V
S
I
A
P
V
V
P
P
----
V
M
M
S
I
A
K
-
S
-
P
D
LDK
H
D
L
S
S
L
R
M
I
K
S
-------
E
L
E
D
T
V
R
A
---
K
F
P
--
Q
A
R
L
G
Q
G
Y
G
M
T
E
A
-----
G
P
V
L
A
M
C
L
A
F
A
---
K
E
P
------
F
D
I
K
P
G
--
A
C
G
TVVRN
A
-
E
M
K
I
V
D
P
E
-
T
G
A
S
L
P
R
--
N
Q
P
G
E
I
C
I
R
G
D
--
Q
I
M
K
G
Y
L
N
--
D
P
E
--
A
---
T
S
---
R
T
I
D
K
E
G
W
L
-------
H
T
G
D
I
G
Y
I
D
D
D
D
E
L
F
I
V
D
R
L
K
E
L
I
K
Y
K
G
F
Q
V
A
P
A
E
L
E
A
L
L
I
A
H
P
E
I
S
D
A
A
V
V
G
L
K
D
E
D
A
G
E
V
P
V
A
F
V
V
K
S
E
K
S
---
Q
---
A
T
E
---
D
E
I
K
Q
-
Y
---
I
S
K
Q
-
V
I
F
Y
K
R
I
K
R
V
F
F
I
E
A
I
P
K
A
P
S
G
K
I
L
R
K
N
L
K
E
K
L
A
------------------
44
HHSearch
76.08
27%
-89
- C3 -
4RLQ
4
?
A:
[8-517]
------------------------------------------------------------------------
F
N
F
A
E
--
H
L
L
Q
T
N
R
V
R
P
D
K
T
A
F
V
D
--
D
--------
I
S
S
L
S
F
A
Q
L
E
A
Q
T
R
Q
L
A
A
A
L
R
A
I
G
V
K
R
E
E
R
V
L
L
L
M
L
D
G
T
D
W
P
V
A
F
L
G
A
I
Y
A
G
I
V
P
V
A
V
N
T
L
L
T
A
D
----
D
Y
A
Y
M
L
E
H
S
R
A
Q
A
V
L
V
---------
S
--------
G
A
L
H
P
V
L
-
K
A
A
---------
L
----
T
--
K
--
S
D
H
E
V
Q
R
V
I
V
S
R
P
A
A
P
L
-----
E
P
G
E
V
D
F
A
E
F
V
G
A
H
A
P
L
E
K
P
A
A
T
Q
A
D
D
P
A
F
W
L
Y
S
S
G
S
T
G
R
P
K
G
V
V
H
T
H
A
N
P
Y
W
T
S
E
L
Y
G
-
R
N
T
----
L
H
L
R
E
D
D
V
C
F
S
A
A
K
L
F
F
A
Y
G
L
G
--
N
A
L
--
T
F
P
M
T
V
G
A
T
-
T
L
-
L
-----
M
G
E
-
R
---
P
T
P
D
A
V
F
--
K
R
W
L
G
G
V
G
G
V
K
P
T
V
F
Y
G
A
P
T
G
Y
A
G
M
L
A
A
P
N
L
-
P
-
S
R
----
D
Q
V
A
L
R
L
A
S
S
A
G
E
A
L
P
A
E
I
G
Q
R
F
Q
R
---
H
F
---
G
L
D
I
V
D
G
I
G
S
T
E
M
-----
L
H
I
F
L
S
N
L
P
D
-----------
R
V
R
Y
G
T
T
G
W
P
V
P
G
-----
Y
-
Q
I
E
L
R
G
-
D
-
G
G
G
P
V
A
D
--
G
E
P
G
D
L
Y
I
H
G
P
--
S
S
A
T
M
Y
W
G
--
N
R
A
K
S
R
---
D
T
---
F
---
Q
G
G
W
T
-------
K
S
G
D
K
Y
V
R
N
D
D
G
S
Y
T
Y
A
G
R
T
D
D
M
L
K
V
S
G
I
Y
V
S
P
F
E
I
E
A
T
L
V
Q
H
P
G
V
L
E
A
A
V
V
G
V
A
D
E
H
G
L
T
K
P
K
A
Y
V
V
P
R
P
G
Q
---
T
---
L
S
E
---
T
E
L
K
T
-
F
---
I
K
D
R
-
L
A
P
Y
K
Y
P
R
S
T
V
F
V
A
E
L
P
K
T
A
T
G
K
I
Q
R
F
K
L
R
E
G
V
-------------------
5
PsiBlast_PDB
75.91
29%
-82
- C3 -
4EAT
3
?
A:
[40-519]
---------------------------------------------------------------------------------------------------------------
S
F
A
Q
L
E
A
Q
T
R
Q
L
A
A
A
L
R
A
I
G
V
K
R
E
E
R
V
L
L
L
M
L
D
G
T
D
W
P
V
A
F
L
G
A
I
Y
A
G
I
V
P
V
A
V
N
T
L
L
T
A
D
----
D
Y
A
Y
M
L
E
H
S
R
A
Q
A
V
L
V
---------
S
--------
G
A
L
H
P
V
L
-
K
A
A
---------
L
----
T
--
K
--
S
-
D
--
H
E
V
Q
R
V
I
V
S
R
P
A
A
P
L
E
P
G
E
--
V
D
F
A
E
F
V
G
A
H
A
P
L
E
K
P
A
A
T
Q
A
D
D
P
A
F
W
L
Y
S
S
G
S
T
G
R
P
K
G
V
V
H
T
H
A
N
P
Y
W
-
T
S
E
L
Y
G
R
N
T
----
L
H
L
R
E
D
D
V
C
F
S
A
A
K
L
F
F
A
Y
G
L
G
N
A
L
-
T
--
F
P
M
T
V
G
A
T
T
-
L
L
-
M
-----
G
E
R
-
P
---
T
P
---
D
A
V
F
K
R
W
L
G
G
V
G
G
V
K
P
T
V
F
Y
G
A
P
T
G
Y
A
G
M
L
A
-
A
P
N
-
L
-
P
S
---
R
D
Q
V
A
L
R
L
A
S
S
A
G
E
A
L
P
A
E
I
G
Q
R
F
Q
R
---
H
F
---
G
L
D
I
V
D
G
I
G
S
T
E
M
-----
L
H
I
F
L
S
--------
N
L
P
D
R
V
R
Y
G
---
T
T
G
W
P
V
P
G
-----
Y
-
Q
I
E
L
R
G
-
D
-
G
G
G
--
P
V
A
D
G
E
P
G
D
L
Y
I
H
G
P
--
S
S
A
T
M
Y
W
G
--
N
R
A
--
K
---
S
R
D
T
-
F
---
Q
G
G
W
T
-------
K
S
G
D
K
Y
V
R
N
D
D
G
S
Y
T
Y
A
G
R
T
D
D
M
L
K
V
S
G
I
Y
V
S
P
F
E
I
E
A
T
L
V
Q
H
P
G
V
L
E
A
A
V
V
G
V
A
D
E
H
G
L
T
K
P
K
A
Y
V
V
P
R
P
G
Q
---
T
---
L
S
E
---
T
E
L
K
T
-
F
---
I
K
D
R
-
L
A
P
Y
K
Y
P
R
S
T
V
F
V
A
E
L
P
K
T
A
T
G
K
I
Q
R
F
K
L
R
----------------------
6
PsiBlast_PDB
75.43
29%
-81
- C3 -
4RMN
3
?
A:
[40-519]
---------------------------------------------------------------------------------------------------------------
S
F
A
Q
L
E
A
Q
T
R
Q
L
A
A
A
L
R
A
I
G
V
K
R
E
E
R
V
L
L
L
M
L
D
G
T
D
W
P
V
A
F
L
G
A
I
Y
A
G
I
V
P
V
A
V
N
T
L
L
T
A
D
----
D
Y
A
Y
M
L
E
H
S
R
A
Q
A
V
L
V
---------
S
--------
G
A
L
H
P
V
L
-
K
A
A
---------
L
----
T
--
K
--
S
-
D
--
H
E
V
Q
R
V
I
V
S
R
P
A
A
P
L
E
P
G
E
--
V
D
F
A
E
F
V
G
A
H
A
P
L
E
K
P
A
A
T
Q
A
D
D
P
A
F
W
L
Y
S
S
G
S
T
G
R
P
K
G
V
V
H
T
H
A
N
P
Y
W
-
T
S
E
L
Y
G
R
N
T
----
L
H
L
R
E
D
D
V
C
F
S
A
A
K
L
F
F
A
Y
G
L
G
N
A
L
-
T
--
F
P
M
T
V
G
A
T
T
-
L
L
-
M
-----
G
E
R
-
P
---
T
P
---
D
A
V
F
K
R
W
L
G
G
V
G
G
V
K
P
T
V
F
Y
G
A
P
T
G
Y
A
G
M
L
A
-
A
P
N
-
L
-
P
S
---
R
D
Q
V
A
L
R
L
A
S
S
A
G
E
A
L
P
A
E
I
G
Q
R
F
Q
R
---
H
F
---
G
L
D
I
V
D
G
I
G
S
T
E
M
-----
L
H
I
F
L
S
--------
N
L
P
D
R
V
R
Y
G
---
T
T
G
W
P
V
P
G
-----
Y
-
Q
I
E
L
R
G
-
D
-
G
G
G
--
P
V
A
D
G
E
P
G
D
L
Y
I
H
G
P
--
S
S
A
T
M
Y
W
G
--
N
R
A
--
K
---
S
R
D
T
-
F
---
Q
G
G
W
T
-------
K
S
G
D
K
Y
V
R
N
D
D
G
S
Y
T
Y
A
G
R
T
D
D
M
L
K
V
S
G
I
Y
V
S
P
F
E
I
E
A
T
L
V
Q
H
P
G
V
L
E
A
A
V
V
G
V
A
D
E
H
G
L
T
K
P
K
A
Y
V
V
P
R
P
G
Q
---
T
---
L
S
E
---
T
E
L
K
T
-
F
---
I
K
D
R
-
L
A
P
Y
K
Y
P
R
S
T
V
F
V
A
E
L
P
K
T
A
T
G
K
I
Q
R
F
K
L
R
----------------------
11
PsiBlast_PDB
75.42
29%
-81
- C3 -
4RM2
2
?
A:
[35-514]
---------------------------------------------------------------------------------------------------------------
S
F
A
Q
L
E
A
Q
T
R
Q
L
A
A
A
L
R
A
I
G
V
K
R
E
E
R
V
L
L
L
M
L
D
G
T
D
W
P
V
A
F
L
G
A
I
Y
A
G
I
V
P
V
A
V
N
T
L
L
T
A
D
----
D
Y
A
Y
M
L
E
H
S
R
A
Q
A
V
L
V
---------
S
--------
G
A
L
H
P
V
L
-
K
A
A
---------
L
----
T
--
K
--
S
-
D
--
H
E
V
Q
R
V
I
V
S
R
P
A
A
P
L
E
P
G
E
--
V
D
F
A
E
F
V
G
A
H
A
P
L
E
K
P
A
A
T
Q
A
D
D
P
A
F
W
L
Y
S
S
G
S
T
G
R
P
K
G
V
V
H
T
H
A
N
P
Y
W
-
T
S
E
L
Y
G
R
N
T
----
L
H
L
R
E
D
D
V
C
F
S
A
A
K
L
F
F
A
Y
G
L
G
N
A
L
-
T
--
F
P
M
T
V
G
A
T
T
-
L
L
-
M
-----
G
E
R
-
P
---
T
P
---
D
A
V
F
K
R
W
L
G
G
V
G
G
V
K
P
T
V
F
Y
G
A
P
T
G
Y
A
G
M
L
A
-
A
P
N
-
L
-
P
S
---
R
D
Q
V
A
L
R
L
A
S
S
A
G
E
A
L
P
A
E
I
G
Q
R
F
Q
R
---
H
F
---
G
L
D
I
V
D
G
I
G
S
T
E
M
-----
L
H
I
F
L
S
--------
N
L
P
D
R
V
R
Y
G
---
T
T
G
W
P
V
P
G
-----
Y
-
Q
I
E
L
R
G
-
D
-
G
G
G
--
P
V
A
D
G
E
P
G
D
L
Y
I
H
G
P
--
S
S
A
T
M
Y
W
G
--
N
R
A
--
K
---
S
R
D
T
-
F
---
Q
G
G
W
T
-------
K
S
G
D
K
Y
V
R
N
D
D
G
S
Y
T
Y
A
G
R
T
D
D
M
L
K
V
S
G
I
Y
V
S
P
F
E
I
E
A
T
L
V
Q
H
P
G
V
L
E
A
A
V
V
G
V
A
D
E
H
G
L
T
K
P
K
A
Y
V
V
P
R
P
G
Q
---
T
---
L
S
E
---
T
E
L
K
T
-
F
---
I
K
D
R
-
L
A
P
Y
K
Y
P
R
S
T
V
F
V
A
E
L
P
K
T
A
T
G
K
I
Q
R
F
K
L
R
----------------------
8
PsiBlast_PDB
75.34
29%
-82
- C3 -
4RM3
1
?
A:
[36-515]
---------------------------------------------------------------------------------------------------------------
S
F
A
Q
L
E
A
Q
T
R
Q
L
A
A
A
L
R
A
I
G
V
K
R
E
E
R
V
L
L
L
M
L
D
G
T
D
W
P
V
A
F
L
G
A
I
Y
A
G
I
V
P
V
A
V
N
T
L
L
T
A
D
----
D
Y
A
Y
M
L
E
H
S
R
A
Q
A
V
L
V
---------
S
--------
G
A
L
H
P
V
L
-
K
A
A
---------
L
----
T
--
K
--
S
-
D
--
H
E
V
Q
R
V
I
V
S
R
P
A
A
P
L
E
P
G
E
--
V
D
F
A
E
F
V
G
A
H
A
P
L
E
K
P
A
A
T
Q
A
D
D
P
A
F
W
L
Y
S
S
G
S
T
G
R
P
K
G
V
V
H
T
H
A
N
P
Y
W
-
T
S
E
L
Y
G
R
N
T
----
L
H
L
R
E
D
D
V
C
F
S
A
A
K
L
F
F
A
Y
G
L
G
N
A
L
-
T
--
F
P
M
T
V
G
A
T
T
-
L
L
-
M
-----
G
E
R
-
P
---
T
P
---
D
A
V
F
K
R
W
L
G
G
V
G
G
V
K
P
T
V
F
Y
G
A
P
T
G
Y
A
G
M
L
A
-
A
P
N
-
L
-
P
S
---
R
D
Q
V
A
L
R
L
A
S
S
A
G
E
A
L
P
A
E
I
G
Q
R
F
Q
R
---
H
F
---
G
L
D
I
V
D
G
I
G
S
T
E
M
-----
L
H
I
F
L
S
--------
N
L
P
D
R
V
R
Y
G
---
T
T
G
W
P
V
P
G
-----
Y
-
Q
I
E
L
R
G
-
D
-
G
G
G
--
P
V
A
D
G
E
P
G
D
L
Y
I
H
G
P
--
S
S
A
T
M
Y
W
G
--
N
R
A
--
K
---
S
R
D
T
-
F
---
Q
G
G
W
T
-------
K
S
G
D
K
Y
V
R
N
D
D
G
S
Y
T
Y
A
G
R
T
D
D
M
L
K
V
S
G
I
Y
V
S
P
F
E
I
E
A
T
L
V
Q
H
P
G
V
L
E
A
A
V
V
G
V
A
D
E
H
G
L
T
K
P
K
A
Y
V
V
P
R
P
G
Q
---
T
---
L
S
E
---
T
E
L
K
T
-
F
---
I
K
D
R
-
L
A
P
Y
K
Y
P
R
S
T
V
F
V
A
E
L
P
K
T
A
T
G
K
I
Q
R
F
K
L
R
----------------------
9
PsiBlast_PDB
75.26
29%
-81
- C3 -
4RLF
5
?
A:
[35-514]
---------------------------------------------------------------------------------------------------------------
S
F
A
Q
L
E
A
Q
T
R
Q
L
A
A
A
L
R
A
I
G
V
K
R
E
E
R
V
L
L
L
M
L
D
G
T
D
W
P
V
A
F
L
G
A
I
Y
A
G
I
V
P
V
A
V
N
T
L
L
T
A
D
----
D
Y
A
Y
M
L
E
H
S
R
A
Q
A
V
L
V
---------
S
--------
G
A
L
H
P
V
L
-
K
A
A
---------
L
----
T
--
K
--
S
-
D
--
H
E
V
Q
R
V
I
V
S
R
P
A
A
P
L
E
P
G
E
--
V
D
F
A
E
F
V
G
A
H
A
P
L
E
K
P
A
A
T
Q
A
D
D
P
A
F
W
L
Y
S
S
G
S
T
G
R
P
K
G
V
V
H
T
H
A
N
P
Y
W
-
T
S
E
L
Y
G
R
N
T
----
L
H
L
R
E
D
D
V
C
F
S
A
A
K
L
F
F
A
Y
G
L
G
N
A
L
-
T
--
F
P
M
T
V
G
A
T
T
-
L
L
-
M
-----
G
E
R
-
P
---
T
P
---
D
A
V
F
K
R
W
L
G
G
V
G
G
V
K
P
T
V
F
Y
G
A
P
T
G
Y
A
G
M
L
A
-
A
P
N
-
L
-
P
S
---
R
D
Q
V
A
L
R
L
A
S
S
A
G
E
A
L
P
A
E
I
G
Q
R
F
Q
R
---
H
F
---
G
L
D
I
V
D
G
I
G
S
T
E
M
-----
L
H
I
F
L
S
--------
N
L
P
D
R
V
R
Y
G
---
T
T
G
W
P
V
P
G
-----
Y
-
Q
I
E
L
R
G
-
D
-
G
G
G
--
P
V
A
D
G
E
P
G
D
L
Y
I
H
G
P
--
S
S
A
T
M
Y
W
G
--
N
R
A
--
K
---
S
R
D
T
-
F
---
Q
G
G
W
T
-------
K
S
G
D
K
Y
V
R
N
D
D
G
S
Y
T
Y
A
G
R
T
D
D
M
L
K
V
S
G
I
Y
V
S
P
F
E
I
E
A
T
L
V
Q
H
P
G
V
L
E
A
A
V
V
G
V
A
D
E
H
G
L
T
K
P
K
A
Y
V
V
P
R
P
G
Q
---
T
---
L
S
E
---
T
E
L
K
T
-
F
---
I
K
D
R
-
L
A
P
Y
K
Y
P
R
S
T
V
F
V
A
E
L
P
K
T
A
T
G
K
I
Q
R
F
K
L
R
----------------------
12
PsiBlast_PDB
52.66
30%
-82
- C3 -
5BUR
8
MENE_BACSU
A:
[142-480]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
M
Q
M
D
--
A
T
A
T
L
M
Y
T
S
G
T
T
G
K
P
K
G
V
Q
Q
T
F
G
N
H
Y
F
S
A
V
S
S
A
L
N
------
L
G
I
T
E
Q
D
R
W
L
I
A
L
P
L
F
H
I
S
G
L
S
--
A
-
L
--
F
K
S
V
I
Y
G
M
T
-
V
V
-
L
-----
H
Q
R
-----
F
----
S
V
--
S
D
V
L
H
S
I
N
R
H
E
V
T
M
I
S
A
V
Q
T
M
L
A
S
L
L
E
E
T
N
R
-
C
-
P
E
-------
S
I
R
C
I
L
L
G
G
G
P
A
P
L
P
L
L
E
E
C
R
E
---
K
----
G
F
P
V
F
Q
S
Y
G
M
T
E
T
C----
S
Q
I
V
T
L
S
--
P
E
---
F
S
M
E
K
L
G
S
A
-----
G
K
P
L
F
S
-----
C
-
E
I
K
I
-
E
-
R
-
D
G
Q
V
C
--
E
P
Y
E
H
G
E
I
M
V
K
G
P
--
N
V
M
K
S
Y
F
N
R
E
S
A
N
--
E
---
A
S
---
F
---
Q
N
G
W
L
-------
K
T
G
D
L
G
Y
L
D
N
E
G
F
L
Y
V
L
D
R
R
S
D
L
I
I
S
G
G
E
N
I
Y
P
A
E
V
E
S
V
L
L
S
H
P
A
V
A
E
A
G
V
S
G
A
E
D
K
--
G
K
V
P
H
A
Y
L
V
L
H
K
-----
P
---
V
S
A
---
G
E
L
T
D
-
Y
---
C
K
E
R
-
L
A
K
Y
K
I
P
A
K
F
F
V
L
D
R
L
P
R
N
A
S
N
K
L
L
R
N
Q
L
K
----------------------