@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1392: (2016-05-01 )
MSEKGRLFTSESVTEGHPDKICDAISDSVLDALLAADPRSRVAVETLVTTGQVHVVGEVTTSAKEAFADITNTVRARILEIGYDSSDKGFDGATCGVNIGIGAQSPDIAQGVDTAHEARVEGAADPLDSQGAGDQGLMFGYAINATPELMPLPIALAHRLSRRLTEVRKNGVLPYLRPDGKTQVTIAYEDNVPVRLDTVVISTQHAADIDLEKTLDPDIREKVLNTVLDDLAHETLDASTVRVLVNPTGKFVLGGPMGDAGLTGRKIIVDTYGGWARHGGGAFSGKDPSKVDRSAAYAMRWVAKNVVAAGLAERVEVQVAYAIGKAAPVGLFVETFGTETEDPVKIEKAIGEVFDLRPGAIIRDLNLLRPIYAPTAAYGHFGRTDVELPWEQLDKVDDLKRAI
Atome Classification :
(30 SA)
......-...10........20........30........40........50........60.....---...70........80........90........100.......110.......120.......130.......140.......150.......160.......170--.---.......180......-.190---........200.......210.......220.......230.-......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340--........350.......360.......370.......380.......390.......400.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSEKG
R
-
L
FTSESVTEG
H
P
D
K
I
C
D
A
I
S
D
S
V
L
D
A
L
L
AADPRS
R
V
A
V
E
T
L
V
TTG
Q
V
H
V
V
G
EVT
T
S
A
K
E
A
---
F
A
D
I
T
N
T
V
R
A
R
I
LEIGYDSSDKGFDG
A
T
C
G
V
N
IGIGAQSP
D
I
A
Q
GV
D
T
A
H
E
A
RVEGAADPLDSQGAGDQ
G
L
M
F
G
Y
AINATPELMP
L
P
I
A
L
A
H
R
L
S
R
R
L
T
E
V
R
KNG---V---L
P
Y
LRPDG
K
T
Q
V
T
I
A
Y-EDN----V
P
V
R
L
D
T
V
V
I
STQHAADI
D
L
E
KTL
D
P
D
I
R
E
K
V
L
N
T
V
L
D
D
L
A
H
-ETLDA
S
T
V
R
V
L
VNPTG
K
F
V
L
GGPMGDAGLTG
R
K
I
I
V
DTYGGWARHGGGAFSGK
D
P
S
K
V
D
R
S
A
A
Y
A
M
R
W
V
A
K
N
V
V
A
A
G
L
A
E
R
V
E
V
Q
V
A
Y
AIGKAAP
V
G
L
F
V
ETFGTET-E--D
P
V
K
I
E
K
A
I
G
E
V
FDLRPG
A
I
I
R
D
L
N
LLRPIYAPTAAYGHFGRTDVEL
P
W
E
Q
L
D
K
V
D
D
L
K
R
AI
21
PsiBlast_CBE
96.43
99%
-91
- C7 -
3TDE
1
METK_MYCTU
D:
[10-408]
----
G
R
-
L
F
T
S
E
S
V
T
E
G
H
P
D
K
I
C
D
A
I
S
D
S
V
L
D
A
L
L
A
A
D
P
R
S
R
V
A
V
E
T
L
V
T
T
G
Q
V
H
V
V
G
E
V
T
T
S
A
K
E
A
---
F
A
D
I
T
N
T
V
R
A
R
I
L
E
I
G
Y
D
S
S
D
K
G
F
D
G
A
T
C
G
V
N
I
G
I
G
A
Q
S
P
D
-------------------------
G
D
Q
G
L
M
F
G
Y
A
I
N
A
T
P
E
L
M
P
L
P
I
A
L
A
H
R
L
S
R
R
L
T
E
V
R
K
N
G
---
V
---
L
P
Y
L
R
P
D
G
K
T
Q
V
T
I
A
Y
-
E
D
N
----
V
P
V
R
L
D
T
V
V
I
S
T
Q
H
A
A
D
I
D
L
E
K
T
L
D
P
D
I
R
E
K
V
L
N
T
V
L
D
D
L
A
H
-
E
T
L
D
A
S
T
V
R
V
L
V
N
P
T
G
K
F
V
L
G
G
P
M
G
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
M
R
W
V
A
K
N
V
V
A
A
G
L
A
E
R
V
E
V
Q
V
A
Y
A
I
G
K
A
A
P
V
G
L
F
V
E
T
F
G
T
E
T
-
E
--
D
P
V
K
I
E
K
A
I
G
E
V
F
D
L
R
P
G
A
I
I
R
D
L
N
L
L
R
P
I
Y
A
P
T
A
A
Y
G
H
F
G
R
T
D
V
E
L
P
W
E
Q
L
D
K
V
D
D
L
K
R
A
I
1
PsiBlast_PDB
95.83
99%
-92
- C7 -
3TDE
-
METK_MYCTU
A:
[11-408]
-----
R
-
L
F
T
S
E
S
V
T
E
G
H
P
D
K
I
C
D
A
I
S
D
S
V
L
D
A
L
L
A
A
D
P
R
S
R
V
A
V
E
T
L
V
T
T
G
Q
V
H
V
V
G
E
V
T
T
S
A
K
E
A
---
F
A
D
I
T
N
T
V
R
A
R
I
L
E
I
G
Y
D
S
S
D
K
G
F
D
G
A
T
C
G
V
N
I
G
I
G
-----------------------------
A
G
D
Q
G
L
M
F
G
Y
A
I
N
A
T
P
E
L
M
P
L
P
I
A
L
A
H
R
L
S
R
R
L
T
E
V
R
K
N
G
---
V
---
L
P
Y
L
R
P
D
G
K
T
Q
V
T
I
A
Y
-
E
D
N
----
V
P
V
R
L
D
T
V
V
I
S
T
Q
H
A
A
D
I
D
L
E
K
T
L
D
P
D
I
R
E
K
V
L
N
T
V
L
D
D
L
A
H
-
E
T
L
D
A
S
T
V
R
V
L
V
N
P
T
G
K
F
V
L
G
G
P
M
G
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
M
R
W
V
A
K
N
V
V
A
A
G
L
A
E
R
V
E
V
Q
V
A
Y
A
I
G
K
A
A
P
V
G
L
F
V
E
T
F
G
T
E
T
-
E
--
D
P
V
K
I
E
K
A
I
G
E
V
F
D
L
R
P
G
A
I
I
R
D
L
N
L
L
R
P
I
Y
A
P
T
A
A
Y
G
H
F
G
R
T
D
V
E
L
P
W
E
Q
L
D
K
V
D
D
L
K
R
A
I
2
PsiBlast_PDB
95.44
95%
-91
- C7 -
3RV2
4
METK_MYCMM
A:
[9-407]
----
G
R
-
L
F
T
S
E
S
V
T
E
G
H
P
D
K
I
C
D
A
V
S
D
S
V
L
D
A
L
L
A
A
D
P
R
S
R
V
A
V
E
T
L
V
T
T
G
Q
V
H
V
V
G
E
V
T
T
T
A
K
E
A
---
F
A
D
I
T
N
I
V
R
E
R
I
L
D
I
G
Y
D
S
S
D
K
G
F
D
G
A
S
C
G
V
N
I
G
I
G
A
Q
S
P
--------------------------
G
D
Q
G
L
M
F
G
Y
A
I
N
D
T
P
E
L
M
P
L
P
I
A
L
A
H
R
L
S
R
R
L
T
E
V
R
K
N
G
---
V
---
L
P
Y
L
R
P
D
G
K
T
Q
V
T
I
A
Y
-
E
D
R
----
V
P
V
R
L
D
T
V
V
I
S
T
Q
H
A
D
D
I
D
L
V
K
T
L
D
P
D
I
R
E
Q
V
L
K
T
V
L
D
D
L
A
H
-
D
T
L
D
A
S
A
V
R
V
L
V
N
P
T
G
K
F
V
L
G
G
P
M
G
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
M
R
W
V
A
K
N
V
V
A
A
G
L
A
E
R
V
E
V
Q
V
A
Y
A
I
G
K
A
A
P
V
G
L
F
V
E
T
F
G
S
E
A
-
V
--
D
P
V
K
I
E
K
A
I
G
E
V
F
D
L
R
P
G
A
I
I
R
D
L
N
L
L
R
P
I
Y
A
P
T
A
A
Y
G
H
F
G
R
T
D
V
D
L
P
W
E
R
L
D
K
V
D
D
L
K
R
A
I
23
PsiBlast_CBE
95.40
92%
-90
- C7 -
3S82
5
METK_MYCA1
B:
[6-407]
-
S
E
K
G
R
-
L
F
T
S
E
S
V
T
E
G
H
P
D
K
I
C
D
A
I
S
D
S
V
L
D
A
L
L
A
Q
D
P
R
S
R
V
A
V
E
T
L
V
T
T
G
Q
V
H
V
V
G
E
V
T
T
T
A
K
E
A
---
F
A
D
I
T
N
T
V
R
E
R
I
L
D
I
G
Y
D
S
S
D
K
G
F
D
G
A
S
C
G
V
N
I
G
I
G
A
Q
S
P
--------------------------
G
D
Q
G
L
M
F
G
Y
A
I
N
D
T
P
E
R
M
P
L
P
I
A
L
A
H
R
L
S
R
R
L
T
E
V
R
K
N
G
---
V
---
L
P
Y
L
R
P
D
G
K
T
Q
V
T
I
E
F
-
E
D
D
----
V
P
V
R
L
D
T
V
V
I
S
T
Q
H
A
A
D
I
D
L
E
N
T
L
T
P
D
I
R
E
K
V
L
N
T
V
L
N
D
L
A
H
-
D
T
L
D
T
S
S
T
R
L
L
V
N
P
T
G
K
F
V
V
G
G
P
M
G
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
M
R
W
V
A
K
N
I
V
A
A
G
L
A
E
R
V
E
V
Q
V
A
Y
A
I
G
K
A
A
P
V
G
L
F
I
E
T
F
G
T
A
T
-
V
--
D
P
V
K
I
E
K
I
V
P
E
V
F
D
L
R
P
G
A
I
I
R
D
L
D
L
L
R
P
I
Y
A
Q
T
A
A
Y
G
H
F
G
R
T
D
V
E
L
P
W
E
Q
L
N
K
V
D
D
L
K
R
A
I
22
PsiBlast_CBE
94.94
95%
-92
- C7 -
3RV2
5
METK_MYCMM
B:
[9-407]
----
G
R
-
L
F
T
S
E
S
V
T
E
G
H
P
D
K
I
C
D
A
V
S
D
S
V
L
D
A
L
L
A
A
D
P
R
S
R
V
A
V
E
T
L
V
T
T
G
Q
V
H
V
V
G
E
V
T
T
T
A
K
E
A
---
F
A
D
I
T
N
I
V
R
E
R
I
L
D
I
G
Y
D
S
S
D
K
G
F
D
G
A
S
C
G
V
N
I
G
I
G
A
Q
S
P
--------------------------
G
D
Q
G
L
M
F
G
Y
A
I
N
D
T
P
E
L
M
P
L
P
I
A
L
A
H
R
L
S
R
R
L
T
E
V
R
K
N
G
---
V
---
L
P
Y
L
R
P
D
G
K
T
Q
V
T
I
A
Y
-
E
D
R
----
V
P
V
R
L
D
T
V
V
I
S
T
Q
H
A
D
D
I
D
L
V
K
T
L
D
P
D
I
R
E
Q
V
L
K
T
V
L
D
D
L
A
H
-
D
T
L
D
A
S
A
V
R
V
L
V
N
P
T
G
K
F
V
L
G
G
P
M
G
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
M
R
W
V
A
K
N
V
V
A
A
G
L
A
E
R
V
E
V
Q
V
A
Y
A
I
G
K
A
A
P
V
G
L
F
V
E
T
F
G
S
E
A
-
V
--
D
P
V
K
I
E
K
A
I
G
E
V
F
D
L
R
P
G
A
I
I
R
D
L
N
L
L
R
P
I
Y
A
P
T
A
A
Y
G
H
F
G
R
T
D
V
D
L
P
W
E
R
L
D
K
V
D
D
L
K
R
A
I
3
PsiBlast_PDB
94.39
92%
-91
- C7 -
3S82
5
METK_MYCA1
A:
[9-407]
----
G
R
-
L
F
T
S
E
S
V
T
E
G
H
P
D
K
I
C
D
A
I
S
D
S
V
L
D
A
L
L
A
Q
D
P
R
S
R
V
A
V
E
T
L
V
T
T
G
Q
V
H
V
V
G
E
V
T
T
T
A
K
E
A
---
F
A
D
I
T
N
T
V
R
E
R
I
L
D
I
G
Y
D
S
S
D
K
G
F
D
G
A
S
C
G
V
N
I
G
I
G
A
Q
S
P
--------------------------
G
D
Q
G
L
M
F
G
Y
A
I
N
D
T
P
E
R
M
P
L
P
I
A
L
A
H
R
L
S
R
R
L
T
E
V
R
K
N
G
---
V
---
L
P
Y
L
R
P
D
G
K
T
Q
V
T
I
E
F
-
E
D
D
----
V
P
V
R
L
D
T
V
V
I
S
T
Q
H
A
A
D
I
D
L
E
N
T
L
T
P
D
I
R
E
K
V
L
N
T
V
L
N
D
L
A
H
-
D
T
L
D
T
S
S
T
R
L
L
V
N
P
T
G
K
F
V
V
G
G
P
M
G
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
M
R
W
V
A
K
N
I
V
A
A
G
L
A
E
R
V
E
V
Q
V
A
Y
A
I
G
K
A
A
P
V
G
L
F
I
E
T
F
G
T
A
T
-
V
--
D
P
V
K
I
E
K
I
V
P
E
V
F
D
L
R
P
G
A
I
I
R
D
L
D
L
L
R
P
I
Y
A
Q
T
A
A
Y
G
H
F
G
R
T
D
V
E
L
P
W
E
Q
L
N
K
V
D
D
L
K
R
A
I
64
HHSearch
93.35
92%
-88
- C7 -
3S82
5
METK_MYCA1
A:
[9-407]
----
G
R
-
L
F
T
S
E
S
V
T
E
G
H
P
D
K
I
C
D
A
I
S
D
S
V
L
D
A
L
L
A
Q
D
P
R
S
R
V
A
V
E
T
L
V
T
T
G
Q
V
H
V
V
G
E
V
T
T
T
---
A
K
E
A
F
A
D
I
T
N
T
V
R
E
R
I
L
D
I
G
Y
D
S
S
D
K
G
F
D
G
A
S
C
G
V
N
I
G
I
G
A
Q
S
P
--------------------------
G
D
Q
G
L
M
F
G
Y
A
I
N
D
T
P
E
R
M
P
L
P
I
A
L
A
H
R
L
S
R
R
L
T
E
V
R
K
N
G
---
V
---
L
P
Y
L
R
P
D
G
K
T
Q
V
T
I
E
F
-
E
D
D
----
V
P
V
R
L
D
T
V
V
I
S
T
Q
H
A
A
D
I
D
L
E
N
T
L
T
P
D
I
R
E
K
V
L
N
T
V
L
N
D
L
A
H
D
T
L
D
T
S
S
-
T
R
L
L
V
N
P
T
G
K
F
V
V
G
G
P
M
G
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
M
R
W
V
A
K
N
I
V
A
A
G
L
A
E
R
V
E
V
Q
V
A
Y
A
I
G
K
A
A
P
V
G
L
F
I
E
T
F
G
T
A
T
-
V
--
D
P
V
K
I
E
K
I
V
P
E
V
F
D
L
R
P
G
A
I
I
R
D
L
D
L
L
R
P
I
Y
A
Q
T
A
A
Y
G
H
F
G
R
T
D
V
E
L
P
W
E
Q
L
N
K
V
D
D
L
K
R
A
I
69
HHSearch
86.11
61%
-75
- C7 -
1P7L
8
METK_ECOLI
A:
[1-380]
---
A
K
H
-
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
---
A
---
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
D
R
A
----------
D
P
L
E
Q
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
N
G
---
T
---
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
-
D
D
G
----
K
I
V
G
I
D
A
V
V
L
S
T
Q
H
S
E
E
I
D
Q
K
-
S
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
A
----
E
W
L
T
S
A
-
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
-
V
--
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
--
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
D
A
A
5
PsiBlast_PDB
85.92
59%
-75
- C7 -
1P7L
8
METK_ECOLI
A:
[3-379]
-----
H
-
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
------
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
D
R
A
---------
D
P
L
E
-
Q
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
N
G
---
T
---
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
-
D
D
G
----
K
I
V
G
I
D
A
V
V
L
S
T
Q
H
S
E
E
I
D
-
Q
K
S
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
---
P
A
-
E
W
L
T
S
A
T
-
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
-
V
--
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
--
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
D
A
-
27
PsiBlast_CBE
85.83
59%
-74
- C7 -
1P7L
8
METK_ECOLI
D:
[3-379]
-----
H
-
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
------
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
D
R
A
---------
D
P
L
E
-
Q
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
N
G
---
T
---
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
-
D
D
G
----
K
I
V
G
I
D
A
V
V
L
S
T
Q
H
S
E
E
I
D
-
Q
K
S
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
---
P
A
-
E
W
L
T
S
A
T
-
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
-
V
--
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
--
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
D
A
-
28
PsiBlast_CBE
85.76
59%
-73
- C7 -
1P7L
9
METK_ECOLI
C:
[3-379]
-----
H
-
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
------
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
D
R
A
---------
D
P
L
E
-
Q
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
N
G
---
T
---
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
-
D
D
G
----
K
I
V
G
I
D
A
V
V
L
S
T
Q
H
S
E
E
I
D
-
Q
K
S
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
---
P
A
-
E
W
L
T
S
A
T
-
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
-
V
--
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
--
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
D
A
-
24
PsiBlast_CBE
85.65
59%
-75
- C7 -
1RG9
9
METK_ECOLI
D:
[3-379]
-----
H
-
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
------
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
D
R
A
---------
D
P
L
E
-
Q
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
N
G
---
T
---
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
-
D
D
G
----
K
I
V
G
I
D
A
V
V
L
S
T
Q
H
S
E
E
I
D
-
Q
K
S
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
---
P
A
-
E
W
L
T
S
A
T
-
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
-
V
--
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
--
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
D
A
-
25
PsiBlast_CBE
85.63
59%
-74
- C7 -
1RG9
9
METK_ECOLI
C:
[3-379]
-----
H
-
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
------
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
D
R
A
---------
D
P
L
E
-
Q
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
N
G
---
T
---
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
-
D
D
G
----
K
I
V
G
I
D
A
V
V
L
S
T
Q
H
S
E
E
I
D
-
Q
K
S
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
---
P
A
-
E
W
L
T
S
A
T
-
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
-
V
--
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
--
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
D
A
-
6
PsiBlast_PDB
85.45
59%
-74
- C7 -
1RG9
8
METK_ECOLI
A:
[3-379]
-----
H
-
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
------
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
D
R
A
---------
D
P
L
E
-
Q
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
N
G
---
T
---
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
-
D
D
G
----
K
I
V
G
I
D
A
V
V
L
S
T
Q
H
S
E
E
I
D
-
Q
K
S
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
---
P
A
-
E
W
L
T
S
A
T
-
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
-
V
--
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
--
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
D
A
-
11
PsiBlast_PDB
85.36
59%
-75
- C7 -
1XRC
5
METK_ECOLI
A:
[3-379]
-----
H
-
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
------
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
------
D
R
A
---------
D
P
L
E
-
Q
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
N
G
---
T
---
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
-
D
D
G
----
K
I
V
G
I
D
A
V
V
L
S
T
Q
H
S
E
E
I
D
-
Q
K
S
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
---
P
A
-
E
W
L
T
S
A
T
-
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
-
V
--
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
--
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
D
A
-
29
PsiBlast_CBE
85.31
59%
-75
- C7 -
1P7L
8
METK_ECOLI
B:
[3-379]
-----
H
-
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
------
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
D
R
A
---------
D
P
L
E
-
Q
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
N
G
---
T
---
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
-
D
D
G
----
K
I
V
G
I
D
A
V
V
L
S
T
Q
H
S
E
E
I
D
-
Q
K
S
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
---
P
A
-
E
W
L
T
S
A
T
-
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
-
V
--
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
--
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
D
A
-
26
PsiBlast_CBE
85.31
59%
-75
- C7 -
1RG9
8
METK_ECOLI
B:
[3-379]
-----
H
-
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
------
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
D
R
A
---------
D
P
L
E
-
Q
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
N
G
---
T
---
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
-
D
D
G
----
K
I
V
G
I
D
A
V
V
L
S
T
Q
H
S
E
E
I
D
-
Q
K
S
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
---
P
A
-
E
W
L
T
S
A
T
-
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
-
V
--
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
--
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
D
A
-
10
PsiBlast_PDB
85.04
59%
-76
- C7 -
1XRA
5
METK_ECOLI
A:
[3-379]
-----
H
-
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
------
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
------
D
R
A
---------
D
P
L
E
-
Q
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
N
G
---
T
---
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
-
D
D
G
----
K
I
V
G
I
D
A
V
V
L
S
T
Q
H
S
E
E
I
D
-
Q
K
S
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
---
P
A
-
E
W
L
T
S
A
T
-
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
-
V
--
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
--
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
D
A
-
12
PsiBlast_PDB
85.02
58%
-80
- C7 -
1XRB
5
METK_ECOLI
A:
[3-379]
-----
H
-
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
------
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
------
D
R
A
---------
D
P
L
E
-
Q
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
N
G
---
T
---
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
-
D
D
G
----
K
I
V
G
I
D
A
V
V
L
S
T
Q
H
S
E
E
I
D
-
Q
K
S
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
---
P
A
-
E
W
L
T
S
A
T
-
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
-
V
--
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
--
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
D
A
-
65
HHSearch
84.34
55%
-73
- C7 -
5A1I
8
?
A:
[15-393]
--
E
G
T
F
-
L
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
Q
Q
D
P
D
A
K
V
A
C
E
T
V
A
K
T
G
M
I
L
L
A
G
E
I
T
S
R
---
A
---
A
V
D
Y
Q
K
V
V
R
E
A
V
K
H
I
G
Y
D
D
S
S
K
G
F
D
Y
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
D
I
A
Q
G
V
H
L
D
R
---------
N
E
E
D
I
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
A
K
L
A
E
L
R
R
N
G
---
T
---
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
-
M
Q
D
RG
A
V
L
P
I
R
V
H
T
I
V
I
S
V
Q
H
D
E
E
V
C
L
D
-
E
M
R
D
A
L
K
E
K
V
I
K
A
V
V
P
A
----
K
Y
L
D
E
D
-
T
I
Y
H
L
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
G
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
S
H
P
L
S
I
S
I
F
H
Y
G
T
S
Q
-
K
--
S
E
R
E
L
L
E
I
V
K
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
R
T
A
A
Y
G
H
F
G
R
D
--
S
F
P
W
E
V
P
K
K
L
-------
49
PsiBlast_CBE
83.87
53%
-75
- C7 -
2P02
2
METK2_HUMAN
A:
[20-389]
-------
L
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
Q
Q
D
P
D
A
K
V
A
C
E
T
V
A
K
T
G
M
I
L
L
A
G
E
I
T
S
R
A
A
------
V
D
Y
Q
K
V
V
R
E
A
V
K
H
I
G
Y
D
D
S
S
K
G
F
D
Y
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
D
I
A
Q
G
V
---
H
L
D
R
N
E
------
E
D
I
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
A
K
L
A
E
L
R
R
N
G
---
T
---
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
-
M
Q
D
RG
A
V
L
P
I
R
V
H
T
I
V
I
S
V
Q
H
D
E
E
V
C
L
D
E
M
R
D
A
-
L
K
E
K
V
I
K
A
V
V
---
P
A
-
K
Y
L
D
E
D
T
I
Y
H
L
-
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
G
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
S
H
P
L
S
I
S
I
F
H
Y
G
T
S
Q
-
K
--
S
E
R
E
L
L
E
I
V
K
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
R
T
A
A
Y
G
H
F
G
R
D
--
S
F
P
W
E
------------
36
PsiBlast_CBE
83.60
53%
-73
- C7 -
5A1G
8
?
A:
[19-388]
-------
L
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
Q
Q
D
P
D
A
K
V
A
C
E
T
V
A
K
T
G
M
I
L
L
A
G
E
I
T
S
R
A
A
------
V
D
Y
Q
K
V
V
R
E
A
V
K
H
I
G
Y
D
D
S
S
K
G
F
D
Y
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
D
I
A
Q
G
V
---
H
L
D
R
N
E
------
E
D
I
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
A
K
L
A
E
L
R
R
N
G
---
T
---
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
-
M
Q
D
RG
A
V
L
P
I
R
V
H
T
I
V
I
S
V
Q
H
D
E
E
V
C
L
D
E
M
R
D
A
-
L
K
E
K
V
I
K
A
V
V
---
P
A
-
K
Y
L
D
E
D
T
I
Y
H
L
-
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
G
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
S
H
P
L
S
I
S
I
F
H
Y
G
T
S
Q
-
K
--
S
E
R
E
L
L
E
I
V
K
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
R
T
A
A
Y
G
H
F
G
R
D
--
S
F
P
W
E
------------
35
PsiBlast_CBE
83.39
53%
-70
- C7 -
5A1I
8
?
A:
[19-388]
-------
L
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
Q
Q
D
P
D
A
K
V
A
C
E
T
V
A
K
T
G
M
I
L
L
A
G
E
I
T
S
R
A
A
------
V
D
Y
Q
K
V
V
R
E
A
V
K
H
I
G
Y
D
D
S
S
K
G
F
D
Y
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
D
I
A
Q
G
V
---
H
L
D
R
N
E
------
E
D
I
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
A
K
L
A
E
L
R
R
N
G
---
T
---
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
-
M
Q
D
RG
A
V
L
P
I
R
V
H
T
I
V
I
S
V
Q
H
D
E
E
V
C
L
D
E
M
R
D
A
-
L
K
E
K
V
I
K
A
V
V
---
P
A
-
K
Y
L
D
E
D
T
I
Y
H
L
-
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
G
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
S
H
P
L
S
I
S
I
F
H
Y
G
T
S
Q
-
K
--
S
E
R
E
L
L
E
I
V
K
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
R
T
A
A
Y
G
H
F
G
R
D
--
S
F
P
W
E
------------
19
PsiBlast_PDB
83.18
55%
-75
- C7 -
2OBV
6
METK1_HUMAN
A:
[8-377]
-------
M
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
K
Q
D
P
N
A
K
V
A
C
E
T
V
C
K
T
G
M
V
L
L
C
G
E
I
T
S
M
A
------
M
V
D
Y
Q
R
V
V
R
D
T
I
K
H
I
G
Y
D
D
S
A
K
G
F
D
F
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
D
I
A
Q
C
V
---
H
L
D
R
N
E
------
E
D
V
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
I
L
A
H
K
L
N
A
R
M
A
D
L
R
R
S
G
---
L
---
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
M
Q
D
N
G
A
V
-
I
P
V
R
I
H
T
I
V
I
S
V
Q
H
N
E
D
I
T
L
E
E
-
M
R
R
A
L
K
E
Q
V
I
R
A
V
V
---
P
A
-
K
Y
L
D
E
D
T
V
Y
H
L
-
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
V
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
A
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
A
E
P
L
S
I
S
I
F
T
Y
G
T
S
Q
-
K
--
T
E
R
E
L
L
D
V
V
H
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
K
T
A
C
Y
G
H
F
G
R
S
--
E
F
P
W
E
------------
31
PsiBlast_CBE
82.83
55%
-85
- C7 -
1O9T
8
METK1_RAT
A:
[17-389]
----
G
A
F
M
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
K
Q
D
P
N
A
K
V
A
C
E
T
V
C
K
T
G
M
V
L
L
C
G
E
I
T
S
M
A
------
M
I
D
Y
Q
R
V
V
R
D
T
I
K
H
I
G
Y
D
D
S
A
K
G
F
D
F
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
---------------------
E
D
V
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
T
R
M
A
D
L
R
R
S
G
---
V
---
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
V
Q
D
N
GA
V
-
I
P
V
R
V
H
T
I
V
I
S
V
Q
H
N
E
D
I
T
L
E
-
A
M
R
E
A
L
K
E
Q
V
I
K
A
V
V
---
P
A
-
K
Y
L
D
E
D
T
I
Y
H
L
-
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
V
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
A
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
A
E
P
L
S
I
S
I
F
T
Y
G
T
S
K
-
K
--
T
E
R
E
L
L
E
V
V
N
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
K
T
A
C
Y
G
H
F
G
R
S
--
E
F
P
W
E
------------
37
PsiBlast_CBE
82.75
53%
-77
- C7 -
5A19
9
?
A:
[19-388]
-------
L
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
Q
Q
D
P
D
A
K
V
A
C
E
T
V
A
K
T
G
M
I
L
L
A
G
E
I
T
S
R
A
A
------
V
D
Y
Q
K
V
V
R
E
A
V
K
H
I
G
Y
D
D
S
S
K
G
F
D
Y
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
--------------
E
------
E
D
I
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
A
K
L
A
E
L
R
R
N
G
---
T
---
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
-
M
Q
D
RG
A
V
L
P
I
R
V
H
T
I
V
I
S
V
Q
H
D
E
E
V
C
L
D
E
M
R
D
A
-
L
K
E
K
V
I
K
A
V
V
---
P
A
-
K
Y
L
D
E
D
T
I
Y
H
L
-
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
G
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
S
H
P
L
S
I
S
I
F
H
Y
G
T
S
Q
-
K
--
S
E
R
E
L
L
E
I
V
K
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
R
T
A
A
Y
G
H
F
G
R
D
--
S
F
P
W
E
------------
16
PsiBlast_PDB
82.74
55%
-85
- C7 -
1O92
9
METK1_RAT
A:
[17-389]
----
G
A
F
M
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
K
Q
D
P
N
A
K
V
A
C
E
T
V
C
K
T
G
M
V
L
L
C
G
E
I
T
S
M
A
------
M
I
D
Y
Q
R
V
V
R
D
T
I
K
H
I
G
Y
D
D
S
A
K
G
F
D
F
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
---------------------
E
D
V
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
T
R
M
A
D
L
R
R
S
G
---
V
---
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
V
Q
D
N
G
A
V
-
I
P
V
R
V
H
T
I
V
I
S
V
Q
H
N
E
D
I
T
L
E
-
A
M
R
E
A
L
K
E
Q
V
I
K
A
V
V
---
P
A
-
K
Y
L
D
E
D
T
I
Y
H
L
-
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
V
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
A
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
A
E
P
L
S
I
S
I
F
T
Y
G
T
S
K
-
K
--
T
E
R
E
L
L
E
V
V
N
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
K
T
A
C
Y
G
H
F
G
R
S
--
E
F
P
W
E
------------
17
PsiBlast_PDB
82.64
55%
-85
- C7 -
1O93
8
METK1_RAT
A:
[17-389]
----
G
A
F
M
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
K
Q
D
P
N
A
K
V
A
C
E
T
V
C
K
T
G
M
V
L
L
C
G
E
I
T
S
M
A
------
M
I
D
Y
Q
R
V
V
R
D
T
I
K
H
I
G
Y
D
D
S
A
K
G
F
D
F
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
---------------------
E
D
V
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
T
R
M
A
D
L
R
R
S
G
---
V
---
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
V
Q
D
N
G
A
V
-
I
P
V
R
V
H
T
I
V
I
S
V
Q
H
N
E
D
I
T
L
E
-
A
M
R
E
A
L
K
E
Q
V
I
K
A
V
V
---
P
A
-
K
Y
L
D
E
D
T
I
Y
H
L
-
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
V
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
A
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
A
E
P
L
S
I
S
I
F
T
Y
G
T
S
K
-
K
--
T
E
R
E
L
L
E
V
V
N
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
K
T
A
C
Y
G
H
F
G
R
S
--
E
F
P
W
E
------------
52
PsiBlast_CBE
82.55
48%
-76
- C7 -
4ODJ
4
?
A:
[32-409]
-------
L
F
S
S
E
S
V
C
S
G
H
P
D
K
L
C
D
Q
I
S
D
A
I
L
D
A
C
L
E
Q
D
P
E
S
F
V
A
C
E
T
C
T
K
T
G
F
I
M
V
F
G
E
I
T
T
K
A
N
V
N
---
Y
E
R
V
---
V
R
E
T
V
K
E
I
G
Y
D
S
E
E
K
G
L
D
Y
K
T
M
D
V
I
I
K
L
E
Q
Q
S
N
Q
I
A
G
C
V
H
V
--
D
K
N
V
E
D
I
-------
G
A
G
D
Q
G
M
M
F
G
Y
A
T
N
E
T
K
E
L
M
P
L
T
H
V
L
A
T
S
I
T
R
E
L
D
Y
I
R
M
K
G
---
V
SSR
V
G
W
L
R
P
D
G
K
A
Q
V
T
V
E
Y
-
N
C
K
HG
V
L
I
P
K
R
I
H
T
I
L
V
S
V
Q
H
D
E
N
I
E
N
E
E
I
-----
R
E
F
V
L
E
N
V
I
K
K
V
C
P
-
S
D
L
M
D
K
E
T
R
I
L
I
N
P
S
G
R
F
T
I
G
G
P
A
A
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
A
T
K
V
D
R
S
G
A
Y
M
A
R
L
V
A
K
S
I
V
F
S
G
L
C
S
R
C
L
V
Q
V
S
Y
G
I
G
I
A
R
P
L
S
L
Y
I
N
T
F
G
T
A
K
-
D
GY
N
D
T
K
L
L
E
I
V
N
K
V
F
D
F
R
P
G
I
L
I
K
Q
L
N
L
K
S
P
I
F
K
K
T
S
S
G
G
H
F
G
R
S
E
K
E
F
L
W
E
K
-----------
68
HHSearch
82.34
50%
-74
* C7 *
4ODJ
4
?
A:
[29-411]
---
E
Q
F
-
L
F
S
S
E
S
V
C
S
G
H
P
D
K
L
C
D
Q
I
S
D
A
I
L
D
A
C
L
E
Q
D
P
E
S
F
V
A
C
E
T
C
T
K
T
G
F
I
M
V
F
G
E
I
T
T
K
---
A
---
N
V
N
Y
E
R
V
V
R
E
T
V
K
E
I
G
Y
D
S
E
E
K
G
L
D
Y
K
T
M
D
V
I
I
K
L
E
Q
Q
S
N
Q
I
A
G
C
V
H
V
D
K
---------
N
V
E
D
I
G
A
G
D
Q
G
M
M
F
G
Y
A
T
N
E
T
K
E
L
M
P
L
T
H
V
L
A
T
S
I
T
R
E
L
D
Y
I
R
M
K
G
VSS
R
---
V
G
W
L
R
P
D
G
K
A
Q
V
T
V
E
Y
-
N
C
K
HG
V
L
I
P
K
R
I
H
T
I
L
V
S
V
Q
H
D
E
N
I
E
N
E
-
E
I
R
E
F
V
L
E
N
V
I
K
K
V
C
P
S
----
D
L
M
D
K
E
-
T
R
I
L
I
N
P
S
G
R
F
T
I
G
G
P
A
A
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
A
T
K
V
D
R
S
G
A
Y
M
A
R
L
V
A
K
S
I
V
F
S
G
L
C
S
R
C
L
V
Q
V
S
Y
G
I
G
I
A
R
P
L
S
L
Y
I
N
T
F
G
T
A
K
D
G
Y-
N
D
T
K
L
L
E
I
V
N
K
V
F
D
F
R
P
G
I
L
I
K
Q
L
N
L
K
S
P
I
F
K
K
T
S
S
G
G
H
F
G
R
S
E
K
E
F
L
W
E
K
P
I
---------