@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1837c: (2016-05-05 )
MTDRVSVGNLRIARVLYDFVNNEALPGTDIDPDSFWAGVDKVVADLTPQNQALLNARDELQAQIDKWHRRRVIEPIDMDAYRQFLTEIGYLLPEPDDFTITTSGVDAEITTTAGPQLVVPVLNARFALNAANARWGSLYDALYGTDVIPETDGAEKGPTYNKVRGDKVIAYARKFLDDSVPLSSGSFGDATGFTVQDGQLVVALPDKSTGLANPGQFAGYTGAAESPTSVLLINHGLHIEILIDPESQVGTTDRAGVKDVILESAITTIMDFEDSVAAVDAADKVLGYRNWLGLNKGDLAAAVDKDGTAFLRVLNRDRNYTAPGGGQFTLPGRSLMFVRNVGHLMTNDAIVDTDGSEVFEGIMDALFTGLIAIHGLKASDVNGPLINSRTGSIYIVKPKMHGPAEVAFTCELFSRVEDVLGLPQNTMKIGIMDEERRTTVNLKACIKAAADRVVFINTGFLDRTGDEIHTSMEAGPMVRKGTMKSQPWILAYEDHNVDAGLAAGFSGRAQVGKGMWTMTELMADMVETKIAQPRAGASTAWVPSPTAATLHALHYHQVDVAAVQQGLAGKRRATIEQLLTIPLAKELAWAPDEIREEVDNNCQSILGYVVRWVDQGVGCSKVPDIHDVALMEDRATLRISSQLLANWLRHGVITSADVRASLERMAPLVDRQNAGDVAYRPMAPNFDDSIAFLAAQELILSGAQQPNGYTEPILHRRRREFKARAAEKPAPSDRAGDDAAR
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200....-.-..210.......220......-.230.......240.......250.......260.......270.......280.......290.......300.......310-.......320.......330-...-.....340-.......350-........360......-.370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470..-....---.480...-.....490.......500----........510......-.-520------........530-------...-----....540.......550...--------...-.560.......-----.-570---........580......----...590--...---.....600....--------------------...610.......620.......630.......640.......650.-------.......660.......670.......680.......690.......700.......710.......720.......730.......740--
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTDRVSVG
N
L
R
I
A
R
V
L
Y
D
F
VNNEALPGTDI
D
P
D
S
F
W
A
G
V
D
K
V
V
A
DLTPQ
N
Q
A
L
L
N
A
R
D
E
L
Q
A
Q
I
D
K
W
H
R
RRVIEPI
D
M
D
A
Y
R
Q
F
L
T
EIGYLLPEPD
D
F
T
I
TTSGV
D
A
E
I
TTTAG
P
Q
L
V
V
P
VLN
A
R
F
A
LNAANA
R
W
G
S
L
Y
D
A
L
YGTDVIPETDGAEKGPTYNKVRG
D
K
V
I
A
Y
A
R
K
FLDDSVPLSSGSFGDAT
G
F
T
V
QD
G
Q
L
V
V
ALPD-K-STGLANPGQFAGYTGAAES
P
T
-
S
V
L
L
INHG
L
H
I
E
I
L
IDPESQVGTTDRA
G
V
K
D
V
I
L
E
S
A
I
T
T
I
MDFEDSV
A
A
V
D
A
A
D
K
V
L
G
Y
R
N
WLGLNKGD
L
A
A
AVDKD
G
T
A
F
L
R
-
V
L
NRDRNYTAPGGG
Q
F
T
L-P-GR
S
-
L
M
F
V
R
N
V
G
-
H
L
MTN
D
A
I
V--DTD
G
S
E
V
F
E
G
I
M
D
A
L
F
T
-
G
L
I
A
IHGLKASDVNG
P
L
INSRT
G
S
I
Y
I
V
KPKMHGP
A
E
V
A
F
T
C
E
L
F
S
R
V
E
D
V
LGLPQN
T
M
K
I
G
I
MDEER
R
T
T
V
N
L
K
A
C
I
K
A
AAD
R
V
V
F
I
NTGFLDRTG
D
E
I
HTSMEA-GPMV---RKG-TMK-SQ
P
W
I
L
A
Y
EDHNVD
A
G
L-----AAGFSGR
A
Q
VGK
G
M
W
T
M
-
T
-
E
L
-------
M
A
D
M
V
E
T
KIAQ-------PRA-----GASTAWVPSP
T
A
A
T
L
H
A
L
H
Y--------HQ
V
-
D
V
A
-
A
V
Q
Q
G
LA-----G-
K
R
----
R
A
T
I
E
Q
L
L
T
--
I
P
L
A
K
E
----LAWA
P
---
D
E
I
---
R
E
E
V
D
N
N
C
Q
S
I
L
--------------------
G
Y
V
V
R
W
V
DQGVGCSKVPDI
H
D
V
A
L
MEDR
A
T
L
R
I
S
S
Q
L
L
A
N
W
L
RH-GV-------I
T
S
A
D
V
R
A
S
L
E
R
M
A
P
L
VDRQNAGDVAYRPMAPNFD
D
S
I
A
F
L
A
A
Q
E
L
I
L
SGAQQPNGY
T
E
P
I
L
H
R
R
R
R
E
F
K
A
RAAEKPAPSDRAGDDAAR---
1
PsiBlast_PDB
98.44
100%
-90
- C4 -
1N8W
6
MASZ_MYCTO
A:
[5-727]
----
V
S
V
G
N
L
R
I
A
R
V
L
Y
D
F
V
N
N
E
A
L
P
G
T
D
I
D
P
D
S
F
W
A
G
V
D
K
V
V
A
D
L
T
P
Q
N
Q
A
L
L
N
A
R
D
E
L
Q
A
Q
I
D
K
W
H
R
R
R
V
I
E
P
I
D
M
D
A
Y
R
Q
F
L
T
E
I
G
Y
L
L
P
E
P
D
D
F
T
I
T
T
S
G
V
D
A
E
I
T
T
T
A
G
P
Q
L
V
V
P
V
L
N
A
R
F
A
L
N
A
A
N
A
R
W
G
S
L
Y
D
A
L
Y
G
T
D
V
I
P
E
T
D
G
A
E
K
G
P
T
Y
N
K
V
R
G
D
K
V
I
A
Y
A
R
K
F
L
D
D
S
V
P
L
S
S
G
S
F
G
D
A
T
G
F
T
V
Q
D
G
Q
L
V
V
A
L
P
D
-
K
-
S
T
G
L
A
N
P
G
Q
F
A
G
Y
T
G
A
A
E
S
P
T
-
S
V
L
L
I
N
H
G
L
H
I
E
I
L
I
D
P
E
S
Q
V
G
T
T
D
R
A
G
V
K
D
V
I
L
E
S
A
I
T
T
I
M
D
F
E
D
S
V
A
A
V
D
A
A
D
K
V
L
G
Y
R
N
W
L
G
L
N
K
G
D
L
A
A
A
V
-----
A
F
L
R
-
V
L
N
R
D
R
N
Y
T
A
P
G
G
G
Q
F
T
L
-
P
-
G
R
S
-
L
M
F
V
R
N
V
G
-
H
L
M
T
N
D
A
I
V
--
D
T
D
G
S
E
V
F
E
G
I
M
D
A
L
F
T
-
G
L
I
A
I
H
G
L
K
A
S
D
V
N
G
P
L
I
N
S
R
T
G
S
I
Y
I
V
K
P
K
M
H
G
P
A
E
V
A
F
T
C
E
L
F
S
R
V
E
D
V
L
G
L
P
Q
N
T
M
K
I
G
I
M
D
E
E
R
R
T
T
V
N
L
K
A
C
I
K
A
A
A
D
R
V
V
F
I
N
T
G
F
L
D
R
T
G
D
E
I
H
T
S
M
E
A
-
G
P
M
V
---
R
K
G
-
T
M
K
-
S
Q
P
W
I
L
A
Y
E
D
H
N
V
D
A
G
L
-----
A
A
G
F
S
G
R
A
Q
V
G
K
G
M
W
T
M
-
T
-
E
L
-------
M
A
D
M
V
E
T
K
I
A
Q
-------
P
R
A
-----
G
A
S
T
A
W
V
P
S
P
T
A
A
T
L
H
A
L
H
Y
--------
H
Q
V
-
D
V
A
-
A
V
Q
Q
G
L
A
-----
G
-
K
R
----
R
A
T
I
E
Q
L
L
T
--
I
P
L
A
K
E
----
L
A
W
A
P
---
D
E
I
---
R
E
E
V
D
N
N
C
Q
S
I
L
--------------------
G
Y
V
V
R
W
V
D
Q
G
V
G
C
S
K
V
P
D
I
H
D
V
A
L
M
E
D
R
A
T
L
R
I
S
S
Q
L
L
A
N
W
L
R
H
-
G
V
-------
I
T
S
A
D
V
R
A
S
L
E
R
M
A
P
L
V
D
R
Q
N
A
G
D
V
A
Y
R
P
M
A
P
N
F
D
D
S
I
A
F
L
A
A
Q
E
L
I
L
S
G
A
Q
Q
P
N
G
Y
T
E
P
I
L
H
R
R
R
R
E
F
K
A
R
A
A
E
-----------------
5
PsiBlast_PDB
98.36
100%
-86
- C4 -
2GQ3
5
MASZ_MYCTU
A:
[4-729]
-
T
D
R
V
S
V
G
N
L
R
I
A
R
V
L
Y
D
F
V
N
N
E
A
L
P
G
T
D
I
D
P
D
S
F
W
A
G
V
D
K
V
V
A
D
L
T
P
Q
N
Q
A
L
L
N
A
R
D
E
L
Q
A
Q
I
D
K
W
H
R
R
R
---
P
I
D
M
D
A
Y
R
Q
F
L
T
E
I
G
Y
L
L
P
E
P
D
D
F
T
I
T
T
S
G
V
D
A
E
I
T
T
T
A
G
P
Q
L
V
V
P
V
L
N
A
R
F
A
L
N
A
A
N
A
R
W
G
S
L
Y
D
A
L
Y
G
T
D
V
I
P
E
T
D
G
A
E
K
G
P
T
Y
N
K
V
R
G
D
K
V
I
A
Y
A
R
K
F
L
D
D
S
V
P
L
S
S
G
S
F
G
D
A
T
G
F
T
V
Q
D
G
Q
L
V
V
A
L
P
D
-
K
-
S
T
G
L
A
N
P
G
Q
F
A
G
Y
T
G
A
A
E
S
P
T
-
S
V
L
L
I
N
H
G
L
H
I
E
I
L
I
D
P
E
S
Q
V
G
T
T
D
R
A
G
V
K
D
V
I
L
E
S
A
I
T
T
I
M
D
F
E
D
S
V
A
A
V
D
A
A
D
K
V
L
G
Y
R
N
W
L
G
L
N
K
G
D
L
A
A
A
V
D
K
D
G
T
A
F
L
R
-
V
L
N
R
D
R
N
Y
T
A
P
G
G
G
Q
F
T
L
-
P
-
G
R
S
-
L
M
F
V
R
N
V
G
-
H
L
M
T
N
D
A
I
V
--
D
T
D
G
S
E
V
F
E
G
I
M
D
A
L
F
T
-
G
L
I
A
I
H
G
L
K
A
S
D
V
N
G
P
L
I
N
S
R
T
G
S
I
Y
I
V
K
P
K
M
H
G
P
A
E
V
A
F
T
C
E
L
F
S
R
V
E
D
V
L
G
L
P
Q
N
T
M
K
I
G
I
M
D
E
E
R
R
T
T
V
N
L
K
A
C
I
K
A
A
A
D
R
V
V
F
I
N
T
G
F
L
D
R
T
G
D
E
I
H
T
S
M
E
A
-
G
P
M
V
---
R
K
G
-
T
M
K
-
S
Q
P
W
I
L
A
Y
E
D
H
N
V
D
A
G
L
-----
A
A
G
F
S
G
R
A
Q
V
G
K
G
M
W
T
M
-
T
-
E
L
-------
M
A
D
M
V
E
T
K
I
A
Q
-------
P
R
A
-----
G
A
S
T
A
W
V
P
S
P
T
A
A
T
L
H
A
L
H
Y
--------
H
Q
V
-
D
V
A
-
A
V
Q
Q
G
L
A
-----
G
-
K
R
----
R
A
T
I
E
Q
L
L
T
--
I
P
L
A
K
-------
W
A
P
---
D
E
I
---
R
E
E
V
D
N
N
C
Q
S
I
L
--------------------
G
Y
V
V
R
W
V
D
Q
G
V
G
C
S
K
V
P
D
I
H
D
V
A
L
M
E
D
R
A
T
L
R
I
S
S
Q
L
L
A
N
W
L
R
H
-
G
V
-------
I
T
S
A
D
V
R
A
S
L
E
R
M
A
P
L
V
D
R
Q
N
A
G
D
V
A
Y
R
P
M
A
P
N
F
D
D
S
I
A
F
L
A
A
Q
E
L
I
L
S
G
A
Q
Q
P
N
G
Y
T
E
P
I
L
H
R
R
R
R
E
F
K
A
R
A
A
E
-----------------
3
PsiBlast_PDB
98.07
99%
-89
- C4 -
3SAZ
4
MASZ_MYCTU
A:
[2-727]
-
T
D
R
V
S
V
G
N
L
R
I
A
R
V
L
Y
D
F
V
N
N
E
A
L
P
G
T
D
I
D
P
D
S
F
W
A
G
V
D
K
V
V
A
D
L
T
P
Q
N
Q
A
L
L
N
A
R
D
E
L
Q
A
Q
I
D
K
W
H
R
R
R
V
I
E
P
I
D
M
D
A
Y
R
Q
F
L
T
E
I
G
Y
L
L
P
E
P
D
D
F
T
I
T
T
S
G
V
D
A
E
I
T
T
T
A
G
P
Q
L
V
V
P
V
L
N
A
R
F
A
L
N
A
A
N
A
R
W
G
S
L
Y
D
A
L
Y
G
T
D
V
I
P
E
T
D
G
A
E
K
G
P
T
Y
N
K
V
R
G
D
K
V
I
A
Y
A
R
K
F
L
D
D
S
V
P
L
S
S
G
S
F
G
D
A
T
G
F
T
V
Q
D
G
Q
L
V
V
A
L
P
D
-
K
-
S
T
G
L
A
N
P
G
Q
F
A
G
Y
T
G
A
A
E
S
P
T
-
S
V
L
L
I
N
H
G
L
H
I
E
I
L
I
D
P
E
S
Q
V
G
T
T
D
R
A
G
V
K
D
V
I
L
E
S
A
I
T
T
I
M
D
F
E
D
S
V
A
A
V
D
A
A
D
K
V
L
G
Y
R
N
W
L
G
L
N
K
G
D
L
A
A
--------
F
L
R
-
V
L
N
R
D
R
N
Y
T
A
P
G
G
G
Q
F
T
L
-
P
-
G
R
S
-
L
M
F
V
R
N
V
G
-
H
L
M
T
N
D
A
I
V
--
D
T
D
G
S
E
V
F
E
G
I
M
D
A
L
F
T
-
G
L
I
A
I
H
G
L
K
A
S
D
----
L
I
N
S
R
T
G
S
I
Y
I
V
K
P
K
M
H
G
P
A
E
V
A
F
T
C
E
L
F
S
R
V
E
D
V
L
G
L
P
Q
N
T
M
K
I
G
I
M
D
E
E
R
R
T
T
V
N
L
K
A
C
I
K
A
A
A
D
R
V
V
F
I
N
T
G
F
L
D
R
T
G
D
E
I
H
T
S
M
E
A
-
G
P
M
V
---
R
K
G
-
T
M
K
-
S
Q
P
W
I
L
A
Y
E
D
H
N
V
D
A
G
L
-----
A
A
G
F
S
G
R
A
Q
V
G
K
G
M
W
T
M
-
T
-
E
L
-------
M
A
D
M
V
E
T
K
I
A
Q
-------
P
R
A
-----
G
A
S
T
A
W
V
P
S
P
T
A
A
T
L
H
A
L
H
Y
--------
H
Q
V
-
D
V
A
-
A
V
Q
Q
G
L
A
-----
G
-
K
R
----
R
A
T
I
E
Q
L
L
T
--
I
P
L
A
K
E
----
L
A
W
A
P
---
D
E
I
---
R
E
E
V
D
N
N
C
Q
S
I
L
--------------------
G
Y
V
V
R
W
V
D
Q
G
V
G
A
S
K
V
P
D
I
H
D
V
A
L
M
E
D
R
A
T
L
R
I
S
S
Q
L
L
A
N
W
L
R
H
-
G
V
-------
I
T
S
A
D
V
R
A
S
L
E
R
M
A
P
L
V
D
R
Q
N
A
--
V
A
Y
R
P
M
A
P
N
F
D
D
S
I
A
F
L
A
A
Q
E
L
I
L
S
G
A
Q
Q
P
N
G
Y
T
E
P
I
L
H
R
R
R
R
E
F
K
A
R
A
A
E
-----------------
2
PsiBlast_PDB
98.05
99%
-89
- C4 -
3S9I
3
MASZ_MYCTU
A:
[2-727]
-
T
D
R
V
S
V
G
N
L
R
I
A
R
V
L
Y
D
F
V
N
N
E
A
L
P
G
T
D
I
D
P
D
S
F
W
A
G
V
D
K
V
V
A
D
L
T
P
Q
N
Q
A
L
L
N
A
R
D
E
L
Q
A
Q
I
D
K
W
H
R
R
R
V
I
E
P
I
D
M
D
A
Y
R
Q
F
L
T
E
I
G
Y
L
L
P
E
P
D
D
F
T
I
T
T
S
G
V
D
A
E
I
T
T
T
A
G
P
Q
L
V
V
P
V
L
N
A
R
F
A
L
N
A
A
N
A
R
W
G
S
L
Y
D
A
L
Y
G
T
D
V
I
P
E
T
D
G
A
E
K
G
P
T
Y
N
K
V
R
G
D
K
V
I
A
Y
A
R
K
F
L
D
D
S
V
P
L
S
S
G
S
F
G
D
A
T
G
F
T
V
Q
D
G
Q
L
V
V
A
L
P
D
-
K
-
S
T
G
L
A
N
P
G
Q
F
A
G
Y
T
G
A
A
E
S
P
T
-
S
V
L
L
I
N
H
G
L
H
I
E
I
L
I
D
P
E
S
Q
V
G
T
T
D
R
A
G
V
K
D
V
I
L
E
S
A
I
T
T
I
M
D
F
E
D
S
V
A
A
V
D
A
A
D
K
V
L
G
Y
R
N
W
L
G
L
N
K
G
D
L
A
A
---------
L
R
-
V
L
N
R
D
R
N
Y
T
A
P
G
G
G
Q
F
T
L
-
P
-
G
R
S
-
L
M
F
V
R
N
V
G
-
H
L
M
T
N
D
A
I
V
--
D
T
D
G
S
E
V
F
E
G
I
M
D
A
L
F
T
-
G
L
I
A
I
H
G
L
K
A
S
D
--
G
P
L
I
N
S
R
T
G
S
I
Y
I
V
K
P
K
M
H
G
P
A
E
V
A
F
T
C
E
L
F
S
R
V
E
D
V
L
G
L
P
Q
N
T
M
K
I
G
I
M
D
E
E
R
R
T
T
V
N
L
K
A
C
I
K
A
A
A
D
R
V
V
F
I
N
T
G
F
L
D
R
T
G
D
E
I
H
T
S
M
E
A
-
G
P
M
V
---
R
K
G
-
T
M
K
-
S
Q
P
W
I
L
A
Y
E
D
H
N
V
D
A
G
L
-----
A
A
G
F
S
G
R
A
Q
V
G
K
G
M
W
T
M
-
T
-
E
L
-------
M
A
D
M
V
E
T
K
I
A
Q
-------
P
R
A
-----
G
A
S
T
A
W
V
P
S
P
T
A
A
T
L
H
A
L
H
Y
--------
H
Q
V
-
D
V
A
-
A
V
Q
Q
G
L
A
-----
G
-
K
R
----
R
A
T
I
E
Q
L
L
T
--
I
P
L
A
K
E
----
L
A
W
A
P
---
D
E
I
---
R
E
E
V
D
N
N
C
Q
S
I
L
--------------------
G
Y
V
V
R
W
V
D
Q
G
V
G
A
S
K
V
P
D
I
H
D
V
A
L
M
E
D
R
A
T
L
R
I
S
S
Q
L
L
A
N
W
L
R
H
-
G
V
-------
I
T
S
A
D
V
R
A
S
L
E
R
M
A
P
L
V
D
R
Q
N
A
-
D
V
A
Y
R
P
M
A
P
N
F
D
D
S
I
A
F
L
A
A
Q
E
L
I
L
S
G
A
Q
Q
P
N
G
Y
T
E
P
I
L
H
R
R
R
R
E
F
K
A
R
A
A
E
-----------------
4
PsiBlast_PDB
97.91
99%
-90
- C4 -
3SB0
3
MASZ_MYCTU
A:
[2-727]
-
T
D
R
V
S
V
G
N
L
R
I
A
R
V
L
Y
D
F
V
N
N
E
A
L
P
G
T
D
I
D
P
D
S
F
W
A
G
V
D
K
V
V
A
D
L
T
P
Q
N
Q
A
L
L
N
A
R
D
E
L
Q
A
Q
I
D
K
W
H
R
R
R
----
I
D
M
D
A
Y
R
Q
F
L
T
E
I
G
Y
L
L
P
E
P
D
D
F
T
I
T
T
S
G
V
D
A
E
I
T
T
T
A
G
P
Q
L
V
V
P
V
L
N
A
R
F
A
L
N
A
A
N
A
R
W
G
S
L
Y
D
A
L
Y
G
T
D
V
I
P
E
T
D
G
A
E
K
G
P
T
Y
N
K
V
R
G
D
K
V
I
A
Y
A
R
K
F
L
D
D
S
V
P
L
S
S
G
S
F
G
D
A
T
G
F
T
V
Q
D
G
Q
L
V
V
A
L
P
D
-
K
-
S
T
G
L
A
N
P
G
Q
F
A
G
Y
T
G
A
A
E
S
P
T
-
S
V
L
L
I
N
H
G
L
H
I
E
I
L
I
D
P
E
S
Q
V
G
T
T
D
R
A
G
V
K
D
V
I
L
E
S
A
I
T
T
I
M
D
F
E
D
S
V
A
A
V
D
A
A
D
K
V
L
G
Y
R
N
W
L
G
L
N
K
G
D
L
A
A
----------
R
-
V
L
N
R
D
R
N
Y
T
A
P
G
G
G
Q
F
T
L
-
P
-
G
R
S
-
L
M
F
V
R
N
V
G
-
H
L
M
T
N
D
A
I
V
--
D
T
D
G
S
E
V
F
E
G
I
M
D
A
L
F
T
-
G
L
I
A
I
H
G
L
K
A
S
D
----
L
I
N
S
R
T
G
S
I
Y
I
V
K
P
K
M
H
G
P
A
E
V
A
F
T
C
E
L
F
S
R
V
E
D
V
L
G
L
P
Q
N
T
M
K
I
G
I
M
D
E
E
R
R
T
T
V
N
L
K
A
C
I
K
A
A
A
D
R
V
V
F
I
N
T
G
F
L
D
R
T
G
D
E
I
H
T
S
M
E
A
-
G
P
M
V
---
R
K
G
-
T
M
K
-
S
Q
P
W
I
L
A
Y
E
D
H
N
V
D
A
G
L
-----
A
A
G
F
S
G
R
A
Q
V
G
K
G
M
W
T
M
-
T
-
E
L
-------
M
A
D
M
V
E
T
K
I
A
Q
-------
P
R
A
-----
G
A
S
T
A
W
V
P
S
P
T
A
A
T
L
H
A
L
H
Y
--------
H
Q
V
-
D
V
A
-
A
V
Q
Q
G
L
A
-----
G
-
K
R
----
R
A
T
I
E
Q
L
L
T
--
I
P
L
A
K
E
----
L
A
W
A
P
---
D
E
I
---
R
E
E
V
D
N
N
C
Q
S
I
L
--------------------
G
Y
V
V
R
W
V
D
Q
G
V
G
A
S
K
V
P
D
I
H
D
V
A
L
M
E
D
R
A
T
L
R
I
S
S
Q
L
L
A
N
W
L
R
H
-
G
V
-------
I
T
S
A
D
V
R
A
S
L
E
R
M
A
P
L
V
D
R
Q
N
A
G
D
V
A
Y
R
P
M
A
P
N
F
D
D
S
I
A
F
L
A
A
Q
E
L
I
L
S
G
A
Q
Q
P
N
G
Y
T
E
P
I
L
H
R
R
R
R
E
F
K
A
R
A
A
E
-----------------
13
PsiBlast_CBE
97.18
100%
-90
- C4 -
1N8W
3
MASZ_MYCTO
B:
[3-727]
--
D
R
V
S
V
G
N
L
R
I
A
R
V
L
Y
D
F
V
N
N
E
A
L
P
G
T
D
I
D
P
D
S
F
W
A
G
V
D
K
V
V
A
D
L
T
P
Q
N
Q
A
L
L
N
A
R
D
E
L
Q
A
Q
I
D
K
W
H
R
R
R
V
I
E
P
I
D
M
D
A
Y
R
Q
F
L
T
E
I
G
Y
L
L
P
E
P
D
D
F
T
I
T
T
S
G
V
D
A
E
I
T
T
T
A
G
P
Q
L
V
V
P
V
L
N
A
R
F
A
L
N
A
A
N
A
R
W
G
S
L
Y
D
A
L
Y
G
T
D
V
I
P
E
T
----
K
G
P
T
Y
N
K
V
R
G
D
K
V
I
A
Y
A
R
K
F
L
D
D
S
V
P
L
S
S
G
S
F
G
D
A
T
G
F
T
V
Q
D
G
Q
L
V
V
A
L
P
D
-
K
-
S
T
G
L
A
N
P
G
Q
F
A
G
Y
T
G
A
A
E
S
P
T
-
S
V
L
L
I
N
H
G
L
H
I
E
I
L
I
D
P
E
S
Q
V
G
T
T
D
R
A
G
V
K
D
V
I
L
E
S
A
I
T
T
I
M
D
F
E
D
S
V
A
A
V
D
A
A
D
K
V
L
G
Y
R
N
W
L
G
L
N
K
G
D
L
A
A
A
V
------
F
L
R
-
V
L
N
R
D
R
N
Y
T
A
P
G
G
G
Q
F
T
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P
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R
S
-
L
M
F
V
R
N
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--
D
T
D
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S
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I
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T
-
G
L
I
A
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G
L
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N
S
R
T
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S
I
Y
I
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K
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K
M
H
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V
A
F
T
C
E
L
F
S
R
V
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D
V
L
G
L
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Q
N
T
M
K
I
G
I
M
D
E
E
R
R
T
T
V
N
L
K
A
C
I
K
A
A
A
D
R
V
V
F
I
N
T
G
F
L
D
R
T
G
D
E
I
H
T
S
M
E
A
-
G
P
M
V
---
R
K
G
-
T
M
K
-
S
Q
P
W
I
L
A
Y
E
D
H
N
V
D
A
G
L
-----
A
A
G
F
S
G
R
A
Q
V
G
K
G
M
W
T
M
-
T
-
E
L
-------
M
A
D
M
V
E
T
K
I
A
Q
-------
P
R
A
-----
G
A
S
T
A
W
V
P
S
P
T
A
A
T
L
H
A
L
H
Y
--------
H
Q
V
-
D
V
A
-
A
V
Q
Q
G
L
A
-----
G
-
K
R
----
R
A
T
I
E
Q
L
L
T
--
I
P
L
A
K
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----
L
A
W
A
P
---
D
E
I
---
R
E
E
V
D
N
N
C
Q
S
I
L
--------------------
G
Y
V
V
R
W
V
D
Q
G
V
G
C
S
K
V
P
D
I
H
D
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A
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D
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A
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L
R
I
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S
Q
L
L
A
N
W
L
R
H
-
G
V
-------
I
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A
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A
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L
E
R
M
A
P
L
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D
R
Q
N
A
G
D
V
A
Y
R
P
M
A
P
N
F
D
D
S
I
A
F
L
A
A
Q
E
L
I
L
S
G
A
Q
Q
P
N
G
Y
T
E
P
I
L
H
R
R
R
R
E
F
K
A
R
A
A
E
-----------------
38
Fugue
96.74
99%
-88
- C4 -
1N8I
2
MASZ_MYCTO
A:
[2-727]
-
T
D
R
V
S
V
G
N
L
R
I
A
R
V
L
Y
D
F
V
N
N
E
A
L
P
G
T
D
I
D
P
D
S
F
W
A
G
V
D
K
V
V
A
D
L
T
P
Q
N
Q
A
L
L
N
A
R
D
E
L
Q
A
Q
I
D
K
W
H
R
R
------
D
M
D
A
Y
R
Q
F
L
T
E
I
G
Y
L
L
P
E
P
D
D
F
T
I
T
T
S
G
V
D
A
E
I
T
T
T
A
G
P
Q
L
V
V
P
V
L
N
A
R
F
A
L
N
A
A
N
A
R
W
G
S
L
Y
D
A
L
Y
G
T
D
V
I
P
E
T
D
G
A
E
K
G
P
T
Y
N
K
V
R
G
D
K
V
I
A
Y
A
R
K
F
L
D
D
S
V
P
L
S
S
G
S
F
G
D
A
T
G
F
T
V
Q
D
G
Q
L
V
V
A
L
P
D
-
K
-
S
T
G
L
A
N
P
G
Q
F
A
G
Y
T
G
A
A
E
S
P
T
-
S
V
L
L
I
N
H
G
L
H
I
E
I
L
I
D
P
E
S
Q
V
G
T
T
D
R
A
G
V
K
D
V
I
L
E
S
A
I
T
T
I
M
D
F
E
D
S
V
A
A
V
D
A
A
D
K
V
L
G
Y
R
N
W
L
G
L
N
K
G
D
L
A
----------
A
R
-
V
L
N
R
D
R
N
Y
T
A
P
G
G
G
Q
F
T
L
-
P
-
G
R
S
-
L
M
F
V
R
N
V
G
-
H
L
M
T
N
D
A
I
V
--
D
T
D
G
S
E
V
F
E
G
I
M
D
A
L
F
T
-
G
L
I
A
I
H
G
L
K
A
S
D
I
N
-----
S
R
T
G
S
I
Y
I
V
K
P
K
M
H
G
P
A
E
V
A
F
T
C
E
L
F
S
R
V
E
D
V
L
G
L
P
Q
N
T
M
K
I
G
I
M
D
E
E
R
R
T
T
V
N
L
K
A
C
I
K
A
A
A
D
R
V
V
F
I
N
T
G
F
L
D
R
T
G
D
E
I
H
T
S
M
E
A
-
G
P
M
V
---
R
K
G
-
T
M
K
-
S
Q
P
W
I
L
A
Y
E
D
H
N
V
D
A
G
L
-----
A
A
G
F
S
G
R
A
Q
V
G
K
G
M
W
T
M
-
T
-
E
L
-------
M
A
D
M
V
E
T
K
I
A
Q
-------
P
R
A
-----
G
A
S
T
A
W
V
P
S
P
T
A
A
T
L
H
A
L
H
Y
--------
H
Q
V
-
D
V
A
-
A
V
Q
Q
G
L
A
GKRRA----------
T
I
E
Q
L
L
T
--
I
P
L
A
K
E
----
L
A
W
A
P
---
D
E
I
---
R
E
E
V
D
N
N
C
Q
S
I
L
--------------------
G
Y
V
V
R
W
V
D
Q
G
V
G
C
S
K
V
P
D
I
H
D
V
A
L
M
E
D
R
A
T
L
R
I
S
S
Q
L
L
A
N
W
L
R
H
-
G
V
-------
I
T
S
A
D
V
R
A
S
L
E
R
M
A
P
L
V
D
R
Q
N
----
A
Y
R
P
M
A
P
N
F
D
D
S
I
A
F
L
A
A
Q
E
L
I
L
S
G
A
Q
Q
P
N
G
Y
T
E
P
I
L
H
R
R
R
R
E
F
K
A
R
A
A
E
-----------------
14
PsiBlast_CBE
92.72
82%
-88
- C4 -
4EX4
3
MASZ_MYCLB
B:
[7-733]
--
D
R
V
S
A
G
N
L
R
V
A
R
V
L
Y
D
F
V
N
N
E
A
L
P
G
T
D
I
N
P
N
S
F
W
S
G
V
A
K
V
V
A
D
L
T
P
Q
N
Q
S
L
L
N
S
R
D
E
L
Q
A
Q
I
D
K
W
H
R
H
R
V
I
E
P
F
D
V
D
A
Y
R
Q
F
L
I
D
I
G
Y
L
L
P
E
P
D
D
F
T
I
S
T
S
G
V
D
D
E
I
T
M
T
A
G
P
Q
L
V
V
P
V
L
N
A
R
F
A
L
N
A
A
N
A
R
W
G
S
L
Y
D
A
L
Y
G
T
D
T
I
P
E
T
E
G
A
E
K
G
S
E
Y
N
K
I
R
G
D
K
V
I
A
Y
A
R
K
F
M
D
Q
A
V
P
L
A
S
D
S
W
T
N
A
T
G
V
S
I
F
D
G
Q
L
Q
I
A
I
G
T
-
N
-
S
T
G
L
A
S
P
E
K
F
V
G
Y
N
R
----
S
N
W
S
V
L
L
A
N
H
G
L
H
I
E
V
L
I
D
P
E
S
P
I
G
K
T
D
P
V
G
I
K
D
V
I
L
E
S
A
I
T
T
I
M
D
F
E
D
S
V
T
A
V
D
A
D
D
K
V
R
G
Y
R
N
W
L
G
L
N
K
G
D
L
T
E
E
V
N
K
D
G
K
T
F
T
R
-
V
L
N
A
D
R
S
Y
T
T
P
D
G
G
E
L
T
L
-
P
-
G
R
S
-
L
L
F
V
R
N
V
G
-
H
L
T
T
S
D
A
I
L
VD
D
G
Q
E
K
E
V
F
E
G
I
I
D
A
V
F
T
-
G
L
A
A
I
H
G
L
K
T
G
E
A
N
G
P
L
T
N
S
R
T
G
S
I
Y
I
V
K
P
K
M
H
G
P
A
E
V
A
F
T
C
E
L
F
S
R
V
E
D
V
L
G
L
P
Q
G
T
L
K
V
G
I
M
D
E
E
R
R
T
T
L
N
L
K
A
C
I
K
A
A
A
D
R
V
V
F
I
N
T
G
F
L
D
R
T
G
D
E
I
H
T
S
M
E
A
-
G
P
M
I
---
R
K
G
-
A
M
K
-
N
S
T
W
I
K
A
Y
E
D
A
N
V
D
I
G
L
-----
A
A
G
F
K
G
K
A
Q
I
G
K
G
M
W
A
M
-
T
-
E
L
-------
M
A
D
M
V
E
Q
K
I
G
Q
-------
P
K
A
-----
G
A
T
T
A
W
V
P
S
P
T
A
A
T
L
H
A
M
H
Y
--------
H
Q
V
-
D
V
A
-
A
V
Q
Q
E
L
T
-----
G
-
Q
R
----
R
A
T
V
D
Q
L
L
T
--
I
P
L
A
K
K
----
L
A
W
A
P
---
E
E
I
---
R
E
E
V
D
N
D
C
Q
S
I
L
--------------------
G
Y
V
V
R
W
V
D
Q
G
I
G
C
S
K
V
P
D
I
H
N
V
A
L
M
E
D
R
A
T
L
R
I
S
S
Q
L
L
A
N
W
L
R
H
-
G
V
-------
I
T
S
E
D
V
R
A
S
L
E
R
M
A
P
L
V
D
Q
Q
N
A
E
D
P
A
Y
R
P
M
A
P
N
F
D
D
S
I
A
F
L
A
A
Q
E
L
I
L
S
G
A
Q
Q
P
N
G
Y
T
E
P
I
L
H
R
R
R
R
E
F
K
A
Q
--------------------
16
HHSearch
83.83
58%
-83
* C4 *
1P7T
4
MASZ_ECOLI
A:
[4-722]
---
T
I
T
Q
S
R
L
R
I
D
A
N
F
K
R
F
V
D
E
E
V
L
P
G
T
G
L
D
A
A
A
F
W
R
N
F
D
E
I
V
H
D
L
A
P
E
N
R
Q
L
L
A
E
R
D
R
I
Q
A
A
L
D
E
W
H
R
S
N
P
G
P
V
K
D
K
A
A
Y
K
S
F
L
R
E
L
G
Y
L
V
P
Q
P
E
R
V
T
V
E
T
T
G
I
D
S
E
I
T
S
Q
A
G
P
Q
L
V
V
P
A
M
N
A
R
Y
A
L
N
A
A
N
A
R
W
G
S
L
Y
D
A
L
Y
G
S
D
I
I
P
Q
----------
D
P
Q
R
G
E
Q
V
I
A
W
V
R
R
F
L
D
E
S
L
P
L
E
N
G
S
Y
Q
D
V
V
A
F
K
V
V
D
K
Q
L
R
I
Q
L
K
N
-
G
K
E
T
T
L
R
T
P
A
Q
F
V
G
Y
R
G
D
A
A
A
P
T
-
C
I
L
L
K
N
N
G
L
H
I
E
L
Q
I
D
A
N
G
R
I
G
K
D
D
P
A
H
I
N
D
V
I
V
E
A
A
I
S
T
I
L
D
C
E
D
S
V
A
A
V
D
A
E
D
K
I
L
L
Y
R
N
L
L
G
L
M
Q
G
T
L
Q
E
K
M
-----
Q
I
V
R
-
K
L
N
D
D
R
H
Y
T
A
A
D
G
S
E
I
S
L
-
H
-
G
R
S
-
L
L
F
I
R
N
V
G
-
H
L
M
T
I
P
V
I
W
--
D
S
E
G
N
E
I
P
E
G
I
L
D
G
V
M
T
-
G
A
I
A
L
Y
D
L
K
V
Q
------
K
N
S
R
T
G
S
V
Y
I
V
K
P
K
M
H
G
P
Q
E
V
A
F
A
N
K
L
F
T
R
I
E
T
M
L
G
M
A
P
N
T
L
K
M
G
I
M
D
E
E
R
R
T
S
L
N
L
R
S
C
I
A
Q
A
R
N
R
V
A
F
I
N
T
G
F
L
D
R
T
G
D
E
M
H
S
V
M
E
A
-
G
P
M
L
---
R
K
N
-
Q
M
K
-
S
T
P
W
I
K
A
Y
E
R
N
N
V
L
S
G
L
-----
F
C
G
L
R
G
K
A
Q
I
G
K
G
M
W
A
M
-
P
-
D
L
-------
M
A
D
M
Y
S
Q
K
G
D
Q
-------
L
R
A
-----
G
A
N
T
A
W
V
P
S
P
T
A
A
T
L
H
A
L
H
Y
--------
H
Q
T
-
N
V
Q
-
S
V
Q
A
N
I
A
-----
Q
T
E
F
NAE
F
E
P
L
L
D
D
L
L
T
--
I
P
V
A
E
N
----
A
N
W
S
A
---
Q
E
I
---
Q
Q
E
L
D
N
N
V
Q
G
I
L
--------------------
G
Y
V
V
R
W
V
E
Q
G
I
G
C
S
K
V
P
D
I
H
N
V
A
L
M
E
D
R
A
T
L
R
I
S
S
Q
H
I
A
N
W
L
R
H
-
G
I
-------
L
T
K
E
Q
V
Q
A
S
L
E
N
M
A
K
V
V
D
Q
Q
N
A
G
D
P
A
Y
R
P
M
A
G
N
F
A
N
S
C
A
F
K
A
A
S
D
L
I
F
L
G
V
K
Q
P
N
G
Y
T
E
P
L
L
H
A
W
R
L
R
E
K
E
S
--------------------
15
PsiBlast_CBE
83.73
57%
-83
- C4 -
1P7T
5
MASZ_ECOLI
B:
[8-716]
-------
S
R
L
R
I
D
A
N
F
K
R
F
V
D
E
E
V
L
P
G
T
G
L
D
A
A
A
F
W
R
N
F
D
E
I
V
H
D
L
A
P
E
N
R
Q
L
L
A
E
R
D
R
I
Q
A
A
L
D
E
W
H
R
S
N
P
G
P
V
K
D
K
A
A
Y
K
S
F
L
R
E
L
G
Y
L
V
P
Q
P
E
R
V
T
V
E
T
T
G
I
D
S
E
I
T
S
Q
A
G
P
Q
L
V
V
P
A
M
N
A
R
Y
A
L
N
A
A
N
A
R
W
G
S
L
Y
D
A
L
Y
G
S
D
I
I
P
Q
E
----
S
G
--
Y
D
P
Q
R
G
E
Q
V
I
A
W
V
R
R
F
L
D
E
S
L
P
L
E
N
G
S
Y
Q
D
V
V
A
F
K
V
V
D
K
Q
L
R
I
Q
L
K
N
G
K
-
E
T
T
L
R
T
P
A
Q
F
V
G
Y
R
G
D
A
A
A
P
T
-
C
I
L
L
K
N
N
G
L
H
I
E
L
Q
I
D
A
N
G
R
I
G
K
D
D
P
A
H
I
N
D
V
I
V
E
A
A
I
S
T
I
L
D
C
E
D
S
V
A
A
V
D
A
E
D
K
I
L
L
Y
R
N
L
L
G
L
M
Q
G
T
L
Q
E
K
M
------
I
V
R
-
K
L
N
D
D
R
H
Y
T
A
A
D
G
S
E
I
S
L
-
H
-
G
R
S
-
L
L
F
I
R
N
V
G
-
H
L
M
T
I
P
V
I
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--
D
S
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G
N
E
I
P
E
G
I
L
D
G
V
M
T
-
G
A
I
A
L
Y
D
L
K
V
Q
K
------
N
S
R
T
G
S
V
Y
I
V
K
P
K
M
H
G
P
Q
E
V
A
F
A
N
K
L
F
T
R
I
E
T
M
L
G
M
A
P
N
T
L
K
M
G
I
M
D
E
E
R
R
T
S
L
N
L
R
S
C
I
A
Q
A
R
N
R
V
A
F
I
N
T
G
F
L
D
R
T
G
D
E
M
H
S
V
M
E
A
-
G
P
M
L
---
R
K
N
-
Q
M
K
-
S
T
P
W
I
K
A
Y
E
R
N
N
V
L
S
G
L
-----
F
C
G
L
R
G
K
A
Q
I
G
K
G
M
W
A
M
-
P
-
D
L
-------
M
A
D
M
Y
S
Q
K
G
D
Q
-------
L
R
A
-----
G
A
N
T
A
W
V
P
S
P
T
A
A
T
L
H
A
L
H
Y
--------
H
Q
T
-
N
V
Q
-
S
V
Q
A
N
I
A
Q
TEFN
A
-
E
F
----
E
P
L
L
D
D
L
L
T
--
I
P
V
A
E
N
----
A
N
W
S
A
---
Q
E
I
---
Q
Q
E
L
D
N
N
V
Q
G
I
L
--------------------
G
Y
V
V
R
W
V
E
Q
G
I
G
C
S
K
V
P
D
I
H
N
V
A
L
M
E
D
R
A
T
L
R
I
S
S
Q
H
I
A
N
W
L
R
H
-
G
I
-------
L
T
K
E
Q
V
Q
A
S
L
E
N
M
A
K
V
V
D
Q
Q
N
A
G
D
P
A
Y
R
P
M
A
G
N
F
A
N
S
C
A
F
K
A
A
S
D
L
I
F
L
G
V
K
Q
P
N
G
Y
T
E
P
L
L
H
A
W
R
--------------------------
8
PsiBlast_PDB
82.98
57%
-82
- C4 -
1P7T
4
MASZ_ECOLI
A:
[4-716]
---
T
I
T
Q
S
R
L
R
I
D
A
N
F
K
R
F
V
D
E
E
V
L
P
G
T
G
L
D
A
A
A
F
W
R
N
F
D
E
I
V
H
D
L
A
P
E
N
R
Q
L
L
A
E
R
D
R
I
Q
A
A
L
D
E
W
H
R
S
N
P
G
P
V
K
D
K
A
A
Y
K
S
F
L
R
E
L
G
Y
L
V
P
Q
P
E
R
V
T
V
E
T
T
G
I
D
S
E
I
T
S
Q
A
G
P
Q
L
V
V
P
A
M
N
A
R
Y
A
L
N
A
A
N
A
R
W
G
S
L
Y
D
A
L
Y
G
S
D
I
I
P
Q
----------
D
P
Q
R
G
E
Q
V
I
A
W
V
R
R
F
L
D
E
S
L
P
L
E
N
G
S
Y
Q
D
V
V
A
F
K
V
V
D
K
Q
L
R
I
Q
L
K
N
G
K
-
E
T
T
L
R
T
P
A
Q
F
V
G
Y
R
G
D
A
A
A
P
T
-
C
I
L
L
K
N
N
G
L
H
I
E
L
Q
I
D
A
N
G
R
I
G
K
D
D
P
A
H
I
N
D
V
I
V
E
A
A
I
S
T
I
L
D
C
E
D
S
V
A
A
V
D
A
E
D
K
I
L
L
Y
R
N
L
L
G
L
M
Q
G
T
L
Q
E
K
M
-----
Q
I
V
R
-
K
L
N
D
D
R
H
Y
T
A
A
D
G
S
E
I
S
L
-
H
-
G
R
S
-
L
L
F
I
R
N
V
G
-
H
L
M
T
I
P
V
I
W
--
D
S
E
G
N
E
I
P
E
G
I
L
D
G
V
M
T
-
G
A
I
A
L
Y
D
L
K
V
Q
K
------
N
S
R
T
G
S
V
Y
I
V
K
P
K
M
H
G
P
Q
E
V
A
F
A
N
K
L
F
T
R
I
E
T
M
L
G
M
A
P
N
T
L
K
M
G
I
M
D
E
E
R
R
T
S
L
N
L
R
S
C
I
A
Q
A
R
N
R
V
A
F
I
N
T
G
F
L
D
R
T
G
D
E
M
H
S
V
M
E
A
-
G
P
M
L
---
R
K
N
-
Q
M
K
-
S
T
P
W
I
K
A
Y
E
R
N
N
V
L
S
G
L
-----
F
C
G
L
R
G
K
A
Q
I
G
K
G
M
W
A
M
-
P
-
D
L
-------
M
A
D
M
Y
S
Q
K
G
D
Q
-------
L
R
A
-----
G
A
N
T
A
W
V
P
S
P
T
A
A
T
L
H
A
L
H
Y
--------
H
Q
T
-
N
V
Q
-
S
V
Q
A
N
I
A
Q
TEFN
A
-
E
F
----
E
P
L
L
D
D
L
L
T
--
I
P
V
A
E
N
----
A
N
W
S
A
---
Q
E
I
---
Q
Q
E
L
D
N
N
V
Q
G
I
L
--------------------
G
Y
V
V
R
W
V
E
Q
G
I
G
C
S
K
V
P
D
I
H
N
V
A
L
M
E
D
R
A
T
L
R
I
S
S
Q
H
I
A
N
W
L
R
H
-
G
I
-------
L
T
K
E
Q
V
Q
A
S
L
E
N
M
A
K
V
V
D
Q
Q
N
A
G
D
P
A
Y
R
P
M
A
G
N
F
A
N
S
C
A
F
K
A
A
S
D
L
I
F
L
G
V
K
Q
P
N
G
Y
T
E
P
L
L
H
A
W
R
--------------------------
6
PsiBlast_PDB
78.59
57%
-75
- C4 -
1Y8B
-
MASZ_ECOLI
A:
[1-716]
M
A
Q
T
I
T
Q
S
R
L
R
I
D
A
N
F
K
R
F
V
D
E
E
V
L
P
G
T
G
L
D
A
A
A
F
W
R
N
F
D
E
I
V
H
D
L
A
P
E
N
R
Q
L
L
A
E
R
D
R
I
Q
A
A
L
D
E
W
H
R
S
N
P
G
P
V
K
D
K
A
A
Y
K
S
F
L
R
E
L
G
Y
L
V
P
Q
P
E
R
V
T
V
E
T
T
G
I
D
S
E
I
T
S
Q
A
G
P
Q
L
V
V
P
A
M
N
A
R
Y
A
L
N
A
A
N
A
R
W
G
S
L
Y
D
A
L
Y
G
S
D
I
I
P
Q
E
G
A
M
V
S
G
--
Y
D
P
Q
R
G
E
Q
V
I
A
W
V
R
R
F
L
D
E
S
L
P
L
E
N
G
S
Y
Q
D
V
V
A
F
K
V
V
D
K
Q
L
R
I
Q
L
K
N
G
K
-
E
T
T
L
R
T
P
A
Q
F
V
G
Y
R
G
D
A
A
A
P
T
-
C
I
L
L
K
N
N
G
L
H
I
E
L
Q
I
D
A
N
G
R
I
G
K
D
D
P
A
H
I
N
D
V
I
V
E
A
A
I
S
T
I
L
D
C
E
D
S
V
A
A
V
D
A
E
D
K
I
L
L
Y
R
N
L
L
G
L
M
Q
G
T
L
Q
E
K
M
E
K
N
G
R
Q
I
V
R
-
K
L
N
D
D
R
H
Y
T
A
A
D
G
S
E
I
S
L
-
H
-
G
R
S
-
L
L
F
I
R
N
V
G
-
H
L
M
T
I
P
V
I
W
--
D
S
E
G
N
E
I
P
E
G
I
L
D
G
V
M
T
-
G
A
I
A
L
Y
D
L
K
V
Q
K
------
N
S
R
T
G
S
V
Y
I
V
K
P
K
M
H
G
P
Q
E
V
A
F
A
N
K
L
F
T
R
I
E
T
M
L
G
M
A
P
N
T
L
K
M
G
I
M
D
E
E
R
R
T
S
L
N
L
R
S
C
I
A
Q
A
R
N
R
V
A
F
I
N
T
G
F
L
D
R
T
G
D
E
M
H
S
V
M
E
A
-
G
P
M
L
---
R
K
N
-
Q
M
K
-
S
T
P
W
I
K
A
Y
E
R
N
N
V
L
S
G
L
-----
F
C
G
L
R
G
K
A
Q
I
G
K
G
M
W
A
M
-
P
-
D
L
-------
M
A
D
M
Y
S
Q
K
G
D
Q
-------
L
R
A
-----
G
A
N
T
A
W
V
P
S
P
T
A
A
T
L
H
A
L
H
Y
--------
H
Q
T
-
N
V
Q
-
S
V
Q
A
N
I
A
Q
T
EFN
A
-
E
F
----
E
P
L
L
D
D
L
L
T
--
I
P
V
A
E
N
----
A
N
W
S
A
---
Q
E
I
---
Q
Q
E
L
D
N
N
V
Q
G
I
L
--------------------
G
Y
V
V
R
W
V
E
Q
G
I
G
C
S
K
V
P
D
I
H
N
V
A
L
M
E
D
R
A
T
L
R
I
S
S
Q
H
I
A
N
W
L
R
H
-
G
I
-------
L
T
K
E
Q
V
Q
A
S
L
E
N
M
A
K
V
V
D
Q
Q
N
A
G
D
P
A
Y
R
P
M
A
G
N
F
A
N
S
C
A
F
K
A
A
S
D
L
I
F
L
G
V
K
Q
P
N
G
Y
T
E
P
L
L
H
A
W
R
--------------------------
7
PsiBlast_PDB
75.02
57%
-60
- C4 -
2JQX
-
MASZ_ECOLI
A:
[1-716]
M
A
Q
T
I
T
Q
S
R
L
R
I
D
A
N
F
K
R
F
V
D
E
E
V
L
P
G
T
G
L
D
A
A
A
F
W
R
N
F
D
E
I
V
H
D
L
A
P
E
N
R
Q
L
L
A
E
R
D
R
I
Q
A
A
L
D
E
W
H
R
S
N
P
G
P
V
K
D
K
A
A
Y
K
S
F
L
R
E
L
G
Y
L
V
P
Q
P
E
R
V
T
V
E
T
T
G
I
D
S
E
I
T
S
Q
A
G
P
Q
L
V
V
P
A
M
N
A
R
Y
A
L
N
A
A
N
A
R
W
G
S
L
Y
D
A
L
Y
G
S
D
I
I
P
Q
E
G
A
M
V
S
G
--
Y
D
P
Q
R
G
E
Q
V
I
A
W
V
R
R
F
L
D
E
S
L
P
L
E
N
G
S
Y
Q
D
V
V
A
F
K
V
V
D
K
Q
L
R
I
Q
L
K
N
G
K
-
E
T
T
L
R
T
P
A
Q
F
V
G
Y
R
G
D
A
A
A
P
T
-
C
I
L
L
K
N
N
G
L
H
I
E
L
Q
I
D
A
N
G
R
I
G
K
D
D
P
A
H
I
N
D
V
I
V
E
A
A
I
S
T
I
L
D
C
E
D
S
V
A
A
V
D
A
E
D
K
I
L
L
Y
R
N
L
L
G
L
M
Q
G
T
L
Q
E
K
M
E
K
N
G
R
Q
I
V
R
-
K
L
N
D
D
R
H
Y
T
A
A
D
G
S
E
I
S
L
-
H
-
G
R
S
-
L
L
F
I
R
N
V
G
-
H
L
M
T
I
P
V
I
W
--
D
S
E
G
N
E
I
P
E
G
I
L
D
G
V
M
T
-
G
A
I
A
L
Y
D
L
K
V
Q
K
------
N
S
R
T
G
S
V
Y
I
V
K
P
K
M
H
G
P
Q
E
V
A
F
A
N
K
L
F
T
R
I
E
T
M
L
G
M
A
P
N
T
L
K
M
G
I
M
D
E
E
R
R
T
S
L
N
L
R
S
C
I
A
Q
A
R
N
R
V
A
F
I
N
T
G
F
L
D
R
T
G
D
E
M
H
S
V
M
E
A
-
G
P
M
L
---
R
K
N
-
Q
M
K
-
S
T
P
W
I
K
A
Y
E
R
N
N
V
L
S
G
L
-----
F
C
G
L
R
G
K
A
Q
I
G
K
G
M
W
A
M
-
P
-
D
L
-------
M
A
D
M
Y
S
Q
K
G
D
Q
-------
L
R
A
-----
G
A
N
T
A
W
V
P
S
P
T
A
A
T
L
H
A
L
H
Y
--------
H
Q
T
-
N
V
Q
-
S
V
Q
A
N
I
A
Q
TE
F
N
A
-
E
F
----
E
P
L
L
D
D
L
L
T
--
I
P
V
A
E
N
----
A
N
W
S
A
---
Q
E
I
---
Q
Q
E
L
D
N
N
V
Q
G
I
L
--------------------
G
Y
V
V
R
W
V
E
Q
G
I
G
C
S
K
V
P
D
I
H
N
V
A
L
M
E
D
R
A
T
L
R
I
S
S
Q
H
I
A
N
W
L
R
H
-
G
I
-------
L
T
K
E
Q
V
Q
A
S
L
E
N
M
A
K
V
V
D
Q
Q
N
A
G
D
P
A
Y
R
P
M
A
G
N
F
A
N
S
C
A
F
K
A
A
S
D
L
I
F
L
G
V
K
Q
P
N
G
Y
T
E
P
L
L
H
A
W
R
--------------------------
19
HHSearch
48.60
22%
-62
- C4 -
3CUZ
3
MASY_ECOLI
A:
[87-527]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
R
R
V
E
I
T
-------
G
P
V
E
R
K
M
V
I
N
A
L
N
A
N
V
K
V
F
M
A
D
F
E
D
S
L
A
-----------
P
D
W
N
K
V
I
D
G
Q
I
N
L
R
---------
D
-
A
V
N
G
T
I
S
Y
T
N
E
A
G
K
I
Y
Q
L
-
K
P
N
P
A
-
V
L
I
C
R
V
R
G
-
L
H
L
P
E
K
H
V
T
--
W
-
R
G
E
A
I
P
G
S
L
F
D
F
----
A
L
Y
F
F
H
N
Y
Q
A
L
------
L
-
A
K
G
S
G
P
Y
F
Y
L
P
K
T
Q
S
W
Q
E
A
A
W
W
S
E
V
F
S
Y
A
E
D
R
F
N
L
P
R
G
T
I
K
A
T
L
L
I
E
T
L
P
A
V
F
Q
M
D
E
I
L
H
A
L
R
D
H
I
V
G
L
N
C
G
R
W
D
Y
I
F
S
Y
I
K
T
L
K
N
Y
P
D
R
V
L
---
P
D
R
Q
A
V
T
M
D
K
P
F
L
N
A
Y
S
R
L
L
I
K
T
C
H
-----
K
---
R
G
A
F
A
M
G
-
G
M
A
A
F
I
P
S
K
D
EEHN
N
Q
V
L
N
K
V
K
A
D
K
S
L
E
-------
A
N
N
-----
G
H
D
G
T
W
I
A
H
P
G
L
A
D
T
A
M
A
V
F
N
D
I
L
GSRK
N
Q
L
-
E
V
M
-
R
E
-
Q
D
A
--------------
P
I
T
A
D
Q
L
L
A
--
P
C
---
D
----
G
E
R
T
E
---
E
G
-------
M
R
A
N
I
R
V
A
V
--------------------
Q
Y
I
E
A
W
I
S
-
G
N
G
C
V
P
I
---
Y
--
G
L
M
E
D
A
A
T
A
E
I
S
R
T
S
I
W
Q
W
I
H
H
-
Q
K
TLSNGKP
V
T
K
A
L
F
R
Q
M
L
G
E
E
M
K
V
I
A
S
E
-
L
G
E
E
R
-------
F
S
-
Q
G
R
F
D
D
A
A
R
L
M
E
Q
I
T
T
-
S
D
E
L
I
D
F
L
T
L
P
G
---------------------------
39
Fugue
46.25
22%
-35
- C4 -
3CUZ
4
MASY_ECOLI
A:
[4-532]
A
T
T
T
D
E
L
----------
A
F
T
R
P
Y
G
E
Q
E
K
Q
I
L
T
A
E
A
V
E
F
L
T
E
L
V
T
H
F
T
P
Q
R
N
K
L
L
A
A
R
I
Q
Q
Q
Q
D
I
D
N
G
T
L
P
---------------------------------------------------------------------------
D
F
I
S
E
T
A
S
I
R
D
A
D
--
W
K
I
R
G
I
P
A
D
L
E
D
R
R
-------------------------------------------------------------------
V
E
I
T
-------
G
P
V
E
R
K
M
V
I
N
A
L
N
A
N
V
K
V
F
M
A
D
F
E
D
S
L
A
P
-
D
W
N
K
V
I
D
G
Q
I
N
L
R
D
A
V
N
G
T
I
--------------------
S
Y
T
N
E
A
G
K
I
Y
Q
L
K
P
-
N
P
A
-
V
L
I
C
R
V
R
G
--
L
H
L
P
E
K
H
V
--
T
W
R
G
E
A
I
P
G
S
L
F
D
F
A
L
Y
-
F
F
H
N
Y
Q
A
L
L
A
K
G
-
S
G
P
---------
Y
F
Y
L
P
K
T
Q
S
W
Q
E
A
A
W
W
S
E
V
F
S
Y
A
E
D
R
F
N
L
P
R
G
T
I
K
A
T
L
L
I
E
T
L
P
A
V
F
Q
M
D
E
I
L
H
A
L
R
D
H
I
V
G
L
N
C
G
R
W
D
Y
I
F
S
Y
I
K
T
L
K
N
Y
-
P
D
R
V
LPD
R
Q
A
-
V
T
M
-
D
K
P
F
L
N
A
Y
S
R
L
L
I
K
T
C
H
K
R
G
A
F
A
M
G
G
M
A
A
F
I
P
S
K
D
E
E
H
N
-
N
-
Q
V
-------
L
N
K
V
K
A
D
K
S
L
E
-------
A
N
N
-----
G
H
D
G
T
W
I
A
H
P
G
L
A
D
T
A
M
A
V
F
--------
N
D
I
L
G
S
R
-
K
N
Q
L
E
V
M
-----
R
-
E
Q
----
D
A
P
I
T
A
D
Q
L
--
L
A
P
C
D
G
------------
E
R
T
---
E
E
G
M
R
A
N
I
R
V
A
V
--------------------
Q
Y
I
E
A
W
I
-
S
G
N
G
C
V
P
I
Y
G
-----
L
M
E
D
A
A
T
A
E
I
S
R
T
S
I
W
Q
W
I
H
H
-
Q
---------------------
K
T
L
S
N
G
K
P
V
T
K
A
L
F
R
Q
M
L
G
E
E
M
K
V
I
A
S
E
L
G
E
E
R
F
S
Q
G
R
-----------
F
D
D
A
A
R
L
M
E
Q
I
T
T
S
D
E
L
I
D
F
L
T
L
P
G
Y
R
L
LA
18
HHSearch
43.65
20%
-57
- C4 -
3CUX
2
?
A:
[84-524]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
R
R
V
E
I
T
-------
G
P
V
D
R
K
M
V
I
N
A
L
N
S
G
A
H
L
F
M
A
D
F
E
D
S
N
S
-----------
P
T
W
E
N
A
I
E
G
Q
I
N
L
R
---------
D
-
A
V
K
G
T
I
S
H
K
N
E
N
G
K
E
Y
R
L
-
N
S
K
T
A
-
V
L
I
V
R
P
R
G
-
W
H
L
E
E
K
H
M
Q
--
V
-
D
G
K
N
M
S
G
S
L
V
D
F
----
G
L
Y
F
F
H
N
A
K
A
L
------
L
E
-
K
G
S
G
P
Y
F
Y
L
P
K
M
E
S
Y
L
E
A
R
L
W
N
D
V
F
V
F
A
Q
K
Y
I
G
I
P
N
G
T
I
K
A
T
V
L
L
E
T
I
H
A
S
F
E
M
D
E
I
L
Y
E
L
K
D
H
S
A
G
L
N
C
G
R
W
D
Y
I
F
S
F
L
K
A
F
R
N
H
N
E
F
L
L
---
P
D
R
A
Q
V
T
M
T
A
P
F
M
R
A
Y
S
L
K
V
I
Q
T
C
H
-----
R
---
R
N
A
P
A
I
G
-------------------
E
K
V
R
A
D
K
E
R
E
-------
A
L
D
-----
G
H
D
G
T
W
V
A
H
P
G
L
V
P
V
A
M
E
V
F
N
H
I
M
KTP-
N
Q
I
-
F
R
K
-
R
--
E
E
I
--------------
H
V
T
E
K
D
L
L
E
--
V
P
V
-------
G
T
I
T
E
---
E
G
-------
L
R
M
N
I
S
V
G
I
--------------------
Q
Y
I
A
S
W
L
S
-
G
R
G
A
A
P
I
---
Y
--
N
L
M
E
D
A
A
T
A
E
I
S
R
A
Q
V
W
Q
W
I
R
H
E
G
G
KLNDGRN
I
T
L
E
L
M
E
E
L
K
E
E
E
L
A
K
I
E
R
E
-
I
G
K
E
A
--------
K
-
K
G
R
F
Q
E
A
T
T
L
F
T
N
L
V
R
-
N
D
E
F
V
P
F
L
T
L
P
G
---------------------------
10
PsiBlast_PDB
40.57
23%
-46
- C4 -
3CV1
2
MASY_ECOLI
A:
[95-463]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
V
E
R
K
M
V
I
N
A
L
N
A
N
V
K
V
F
M
A
D
F
E
D
S
L
A
P
--
D
W
N
K
V
I
-------------------
D
G
Q
I
N
L
R
D
A
V
N
G
T
I
S
Y
T
N
E
A
G
K
I
Y
Q
L
-
K
-
P
N
P
-
A
V
L
I
C
R
V
R
-
G
L
H
L
P
E
K
H
V
--
T
W
R
G
----
E
A
I
P
G
S
L
F
D
F
A
L
Y
F
F
H
N
Y
Q
A
------
L
L
A
K
G
S
G
P
-
Y
F
Y
L
P
K
T
Q
S
W
Q
E
A
A
W
W
S
E
V
F
S
Y
A
E
D
R
F
N
L
P
R
G
T
I
K
A
T
L
L
I
E
T
L
P
A
V
F
Q
M
D
E
I
L
H
A
L
R
D
H
I
V
G
L
N
C
G
R
W
D
Y
I
F
S
Y
I
K
T
L
K
N
Y
-
P
D
R
V
LPD
R
Q
A
-
V
T
M
-
D
K
P
F
L
N
A
Y
S
R
L
L
I
K
T
C
H
-----
K
R
G
A
F
A
M
G
G
M
A
A
F
I
P
S
K
-
D
-
E
E
-------
H
N
N
Q
V
L
N
K
V
K
A
-------
D
K
S
L
E
A
N
N
G
H
D
G
T
W
I
A
H
P
G
L
A
-------------------
D
T
A
M
A
V
F
N
D
I
L
-----
G
-
S
R
----
K
N
Q
L
E
V
M
R
E
QD
A
P
I
T
A
D
----
Q
L
L
A
P
C
D
G
E
R
T
---
E
E
G
M
R
A
N
I
R
V
A
V
--------------------
Q
Y
I
E
A
W
I
S
-
G
N
G
C
V
P
I
-----
Y
G
L
M
E
D
A
A
T
A
E
I
S
R
T
S
I
W
Q
W
I
H
H
------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
39.86
23%
-40
- C4 -
3CV2
4
MASY_ECOLI
A:
[95-463]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
V
E
R
K
M
V
I
N
A
L
N
A
N
V
K
V
F
M
A
D
F
E
D
S
L
A
P
--
D
W
N
K
V
I
-------------------
D
G
Q
I
N
L
R
D
A
V
N
G
T
I
S
Y
T
N
E
A
G
K
I
Y
Q
L
-
K
-
P
N
P
-
A
V
L
I
C
R
V
R
-
G
L
H
L
P
E
K
H
V
--
T
W
R
G
----
E
A
I
P
G
S
L
F
D
F
A
L
Y
F
F
H
N
Y
Q
A
------
L
L
A
K
G
S
G
P
-
Y
F
Y
L
P
K
T
Q
S
W
Q
E
A
A
W
W
S
E
V
F
S
Y
A
E
D
R
F
N
L
P
R
G
T
I
K
A
T
L
L
I
E
T
L
P
A
V
F
Q
M
D
E
I
L
H
A
L
R
D
H
I
V
G
L
N
C
G
R
W
D
Y
I
F
S
Y
I
K
T
L
K
N
Y
-
P
D
R
V
LPD
R
Q
A
-
V
T
M
-
D
K
P
F
L
N
A
Y
S
R
L
L
I
K
T
C
H
-----
K
R
G
A
F
A
M
G
G
M
A
A
F
I
P
S
K
-
D
-
E
E
-------
H
N
N
Q
V
L
N
K
V
K
A
-------
D
K
S
L
E
A
N
N
G
H
D
G
T
W
I
A
H
P
G
L
A
-------------------
D
T
A
M
A
V
F
N
D
I
L
-----
G
-
S
R
----
K
N
Q
L
E
V
M
R
E
QD
A
P
I
T
A
D
----
Q
L
L
A
P
C
D
G
E
R
T
---
E
E
G
M
R
A
N
I
R
V
A
V
--------------------
Q
Y
I
E
A
W
I
S
---
G
N
G
C
V
P
---
I
Y
G
L
M
E
D
A
A
T
A
E
I
S
R
T
S
I
W
Q
W
I
H
H
------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
39.77
23%
-44
- C4 -
3CUZ
3
MASY_ECOLI
A:
[95-463]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
V
E
R
K
M
V
I
N
A
L
N
A
N
V
K
V
F
M
A
D
F
E
D
S
L
A
P
--
D
W
N
K
V
I
-------------------
D
G
Q
I
N
L
R
D
A
V
N
G
T
I
S
Y
T
N
E
A
G
K
I
Y
Q
L
-
K
-
P
N
P
-
A
V
L
I
C
R
V
R
-
G
L
H
L
P
E
K
H
V
--
T
W
R
G
----
E
A
I
P
G
S
L
F
D
F
A
L
Y
F
F
H
N
Y
Q
A
------
L
L
A
K
G
S
G
P
-
Y
F
Y
L
P
K
T
Q
S
W
Q
E
A
A
W
W
S
E
V
F
S
Y
A
E
D
R
F
N
L
P
R
G
T
I
K
A
T
L
L
I
E
T
L
P
A
V
F
Q
M
D
E
I
L
H
A
L
R
D
H
I
V
G
L
N
C
G
R
W
D
Y
I
F
S
Y
I
K
T
L
K
N
Y
-
P
D
R
V
LPD
R
Q
A
-
V
T
M
-
D
K
P
F
L
N
A
Y
S
R
L
L
I
K
T
C
H
-----
K
R
G
A
F
A
M
G
G
M
A
A
F
I
P
S
K
-
D
-
E
E
-------
H
N
N
Q
V
L
N
K
V
K
A
-------
D
K
S
L
E
A
N
N
G
H
D
G
T
W
I
A
H
P
G
L
A
-------------------
D
T
A
M
A
V
F
N
D
I
L
-----
G
-
S
R
----
K
N
Q
L
E
V
M
R
E
QD
A
P
I
T
A
D
----
Q
L
L
A
P
C
D
G
E
R
T
---
E
E
G
M
R
A
N
I
R
V
A
V
--------------------
Q
Y
I
E
A
W
I
S
-
G
N
G
C
V
P
I
-----
Y
G
L
M
E
D
A
A
T
A
E
I
S
R
T
S
I
W
Q
W
I
H
H
------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
31.69
20%
-34
- C4 -
3CUX
2
?
A:
[92-460]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
V
D
R
K
M
V
I
N
A
L
N
S
G
A
H
L
F
M
A
D
F
E
D
S
N
S
P
T
-----------
W
E
N
A
I
E
G
Q
I
N
L
R
D
A
V
K
G
T
-----
I
S
H
K
N
E
N
-----
G
K
E
Y
R
L
-
N
-
S
K
T
A
V
L
I
V
R
P
R
G
W
H
L
--
E
E
K
H
M
--
Q
V
D
G
K
N
M
S
G
S
L
V
D
---
F
-
G
L
Y
F
F
H
N
A
K
A
------
L
L
E
K
G
S
G
P
-
Y
F
Y
L
P
K
M
E
S
Y
L
E
A
R
L
W
N
D
V
F
V
F
A
Q
K
Y
I
G
I
P
N
G
T
I
K
A
T
V
L
L
E
T
I
H
A
S
F
E
M
D
E
I
L
Y
E
L
K
D
H
S
A
G
L
N
C
G
R
W
D
Y
I
F
S
---------------------------
F
L
K
A
F
R
N
H
N
----------
E
F
L
L
P
D
R
A
Q
V
-----
T
M
-
T
-
A
P
-------
F
M
R
A
Y
S
L
K
V
I
Q
T
C
H
R
R
N
A
P
A
I
-----
G
---------------------------
E
K
V
-
R
A
D
-
K
E
R
E
A
L
D
-----
G
-
H
D
----
G
T
W
V
A
H
P
G
L
--
V
P
V
A
M
E
V
F
N
H
I
M
K
T
P
---
N
Q
I
FRK
R
E
E
I
H
V
T
E
K
D
L
L
E
V
P
V
G
T
I
T
E
E
G
L
R
M
N
I
S
V
G
I
Q
Y
I
A
S
W
L
S
-
G
R
G
A
A
P
I
Y
N
-----
L
M
E
D
A
A
T
A
E
I
S
R
A
Q
V
W
Q
W
I
R
H
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