@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1925: (2016-05-06 )
MNDGSRQELRVRSGLLQIEDCLDADGGIALPAGTTLISLIERNIKYVGDLVAYRYLDHARSAAGCALEVTWTQFGMRLAAIGAHVQRFAGPGDRVAILAPQGIDYVCGFYAAIKAGTVAVPLFAPELPGHAERLDTALRDSEPAVILTTAAAKNAVEGFLNNVPRLRKPTVLVIDQIPDREGELFVPVEMDIDAVSHLQYTSGSTRPPVGVEITHRAVGTNLVQMILSIDLLNRNTHGVSWLPLYHDMGLSMIGFPAVYGGHSTLMSPTAFVRRPLRWIQALSEGSRTGRVVTAAPNFAYEWAAQRGLPAQGDDVDLSNVVLIIGSEPVSIDAVTTFNKAFAPYGLPRTAFKPSYGIAEATLLVATIDHAAEPTVVYLDPEQLGAGHATRVAPDAPNAVVHVSCGHVARSLWAVIVDPDTGPEAGAELPDGEIGEVWLQGDNVARGYWGRPEETRMTFGARLQSPLAEGSHADGSAIDDTWLRTGDLGVYLDGELYITGRIADLLTIDGRNHYPQDIEATAAEASPMVRRGYITAFTVPASDGDDRNQRLVIIAERAAGTSRSDPRPALDAIRAAVCNRHGLSVADLSFLPAGAIPRTTSGKLARQACRAQYLSGRLGVH
Atome Classification :
(20 SA)
.........10........20........30........40........50........60......-------..70........80.....-..-.90........100.......110.......120-...--....130.----.......140.......150........160.......170....-------.---..180.-...-...190.......200.......210.......220..-.....-----230.......240.......250-...---....260........270-.......280.--..-....290..-.....300.......-310.-.-.....-320...-..-...330.......340.......350.......360.......370.......380.......390..-.....400.........410.......420---........430.......440.......450.......460.......470.......480--.........490........500.......510.......520.....---..530.......540---------------.----------------.......550.......560--........-570.......580.......590.......600.......610.......620-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNDG
S
R
Q
E
L
R
V
R
SG
L
L
Q
I
E
D
C
LDADG
G
I
ALP
A
G
T
T
L
I
S
L
I
E
R
N
I
K
Y
V
G
D
L
V
A
Y
R
Y
L
D
H
ARSAAG
C
A
L
-------
E
V
T
W
T
QF
G
M
R
L
A
A
I
G
A
H
V
Q
-
R
F-AGPG
D
R
V
A
I
LAPQG
I
D
Y
V
C
G
F
Y
A
A
IKAG
T
V
A
V
P
L
-FAP--ELPG
H
A
-
E
----
R
L
D
T
A
LRDSEP
A
V
I
L
T
T
A
-
A
A
K
N
A
V
E
G
F
L
NNVPRLRK
P
T
V
L
V
I
DQ-------I---PDREG
E
-
L
F
V
-
P
V
E
M
D
I
D
A
V
S
H
L
QYTSGSTRPPV
G
V
E
I
T
H
R
A
V
G
T
N
L
V
Q
-
M
I
L
S
I
-----
D
L
LNRNTHG
V
S
W
L
P
L
Y
H
DMGLSM-IGF---PAVYGG-HSTLMS
P
T
A
F
V
-
R
R
P
L
R
W
I
Q
A
L
S--EG-SRT
G
R
V
V
TA-APN
F
A
Y
E
W
A
AQRGLP-AQGD-D-VDL
S
N
-
V
-
V
L
I
I-GS-EP
V
S
I
D
A
V
TT
F
N
K
AFAPYGLPRTAFKPSYGI
A
E
A
T
L
L
V
A
TIDHAAE
P
T
V
V
Y
L
D
P
E
QLGAGHATRVAPD-AP
N
A
V
V
--
H
V
S
C
G
H
V
A
R
S
L
W
A
V
I
VDPDTG----PEAGAELPDGEI
G
E
V
W
L
QGDNVARGYWGRP
E
E
T
R
M
T
F
G
A
R
L
QS
P
L
AEGSHADGSAID
D
T
----WLRTG
D
L
G
V
Y
L-D
G
E
L
Y
I
T
G
R
I
A
D
L
L
T
IDGRNHYPQ
D
I
E
A
T
AAEASP
M
---
V
RR
G
Y
I
T
A
F
T
V
PAS----------------D----------------GDDRN
Q
R
L
V
I
I
A
ERAAGT-S--RSDP
R
P
A
L
-
D
A
I
R
A
A
V
CNRHGLSVADLSFLPAGAIPRTTS
G
K
L
A
R
Q
A
C
R
A
Q
Y
LSGRLGVH---
61
Fugue
97.91
46%
-100
- C3 -
5EY9
5
FAA32_MYCMM
A:
[3-626]
Y
H
N
P
F
I
V
-----------------
N
G
K
I
R
F
P
E
N
T
N
L
V
R
H
V
E
K
W
A
R
V
R
G
D
K
L
A
Y
R
F
L
D
F
S
T
E
R
D
G
V
E
R
-------
D
I
L
W
S
E
F
S
A
R
N
R
A
V
G
A
R
L
Q
-
Q
V
-
T
Q
P
G
D
R
I
A
I
L
C
P
Q
N
L
D
Y
L
I
S
F
F
G
A
L
Y
S
G
R
I
A
V
P
L
-
F
D
P
----
A
E
H
V
-
G
----
R
L
H
A
V
L
D
D
C
T
P
S
T
I
L
T
T
T
-
D
S
A
E
G
V
R
K
F
I
R
S
R
S
A
K
E
R
P
R
V
I
A
V
D
A
-------
V
---
P
T
E
V
A
S
-
T
W
Q
-
Q
P
N
E
L
--
T
T
A
Y
L
Q
Y
T
-----
V
P
S
G
V
Q
I
T
H
L
N
L
P
T
N
V
L
Q
-
V
L
N
A
L
-----
E
G
Q
E
G
D
-
R
G
V
S
W
L
P
F
F
H
D
M
G
L
I
T
-
V
L
L
---
A
S
V
L
G
H
-
S
F
T
F
M
T
P
A
A
F
V
-
R
R
P
G
R
W
I
R
E
L
A
R-
K
P
-
G
E
T
G
G
T
F
S
A
-
A
P
N
F
A
F
E
H
A
A
M
R
G
V
P
-
R
D
D
E
-
P
P
L
D
L
S
N
-
V
-
K
G
I
L
N
G
S
-
E
P
V
S
P
A
S
M
R
K
F
F
K
A
F
E
P
Y
G
L
R
E
T
A
V
K
P
S
Y
G
L
A
E
A
T
L
F
V
S
T
T
P
M
D
E
V
P
T
V
I
H
V
D
R
D
E
L
N
K
Q
R
F
V
E
V
A
A
D
-
A
P
N
A
V
A
--
Q
V
S
A
G
K
V
G
V
D
E
W
A
V
I
V
D
T
E
T
A
----
S
E
----
L
P
D
G
Q
I
G
E
I
W
L
H
G
N
N
L
G
I
G
Y
W
G
K
E
E
E
S
A
Q
T
F
R
N
I
L
K
S
R
V
P
E
-
S
H
A
E
G
A
P
D
D
G
L
----
W
V
R
T
G
D
Y
G
T
Y
F
-
K
G
H
L
Y
I
A
G
R
I
K
D
L
V
I
I
D
G
R
N
H
Y
P
Q
D
L
E
Y
T
A
Q
E
S
T
K
A
---
L
R
V
G
Y
V
A
A
F
S
V
P
A
N
QLP
Q
K
V
F
D
DPHAGLSF
D
----------------
P
E
D
T
S
E
Q
L
V
I
V
G
E
R
A
A
G
T
-
H
--
K
L
E
Y
Q
P
I
A
-
D
D
I
R
A
A
I
A
V
G
H
G
V
T
V
R
D
V
L
L
V
S
A
G
T
I
P
R
T
S
S
G
K
I
G
R
R
A
C
R
T
A
Y
I
D
G
S
L
R
S
T
VFA
4
PsiBlast_PDB
97.28
45%
-104
- C3 -
5EY9
5
FAA32_MYCMM
A:
[10-620]
------------------------
N
G
K
I
R
F
P
E
N
T
N
L
V
R
H
V
E
K
W
A
R
V
R
G
D
K
L
A
Y
R
F
L
D
F
S
T
E
R
D
G
V
E
R
-------
D
I
L
W
S
E
F
S
A
R
N
R
A
V
G
A
R
L
Q
-
Q
V
-
T
Q
P
G
D
R
I
A
I
L
C
P
Q
N
L
D
Y
L
I
S
F
F
G
A
L
Y
S
G
R
I
A
V
P
L
-
F
D
P
--
A
E
--
H
V
-
G
----
R
L
H
A
V
L
D
D
C
T
P
S
T
I
L
T
T
T
-
D
S
A
E
G
V
R
K
F
I
R
S
R
S
A
K
E
R
P
R
V
I
A
V
D
A
-------
V
---
P
T
E
V
A
S
-
T
W
Q
-
Q
P
--
N
E
L
T
T
A
Y
L
Q
Y
T
-----
V
P
S
G
V
Q
I
T
H
L
N
L
P
T
N
V
L
Q
-
V
L
N
A
L
-----
E
-
G
Q
E
G
D
R
G
V
S
W
L
P
F
F
H
D
M
G
L
I
T
-
V
L
L
---
A
S
V
L
G
H
-
S
F
T
F
M
T
P
A
A
F
V
-
R
R
P
G
R
W
I
R
E
L
A
--
R
K
P
G
E
T
G
G
T
F
S
A
-
A
P
N
F
A
F
E
H
A
A
M
R
G
V
P
-
R
D
D
E
P
P
-
L
D
L
S
N
-
V
-
K
G
I
L
N
G
S
-
E
P
V
S
P
A
S
M
R
K
F
F
K
A
F
E
P
Y
G
L
R
E
T
A
V
K
P
S
Y
G
L
A
E
A
T
L
F
V
S
T
T
P
M
D
E
V
P
T
V
I
H
V
D
R
D
E
L
N
K
Q
R
F
V
E
V
A
A
D
-
A
P
N
A
V
A
--
Q
V
S
A
G
K
V
G
V
D
E
W
A
V
I
V
D
T
E
T
--------
A
S
E
L
P
D
G
Q
I
G
E
I
W
L
H
G
N
N
L
G
I
G
Y
W
G
K
E
E
E
S
A
Q
T
F
R
N
I
L
K
S
R
V
P
E
-
S
H
A
E
G
A
P
D
D
G
L
----
W
V
R
T
G
D
Y
G
T
Y
F
-
K
G
H
L
Y
I
A
G
R
I
K
D
L
V
I
I
D
G
R
N
H
Y
P
Q
D
L
E
Y
T
A
Q
E
S
T
K
A
---
L
R
V
G
Y
V
A
A
F
S
V
P
A
N
QLP
Q
K
V
F
D
DPHAGLSF
D
----------------
P
E
D
T
S
E
Q
L
V
I
V
G
E
R
A
A
G
T
-
H
--
K
L
E
Y
Q
P
I
A
-
D
D
I
R
A
A
I
A
V
G
H
G
V
T
V
R
D
V
L
L
V
S
A
G
T
I
P
R
T
S
S
G
K
I
G
R
R
A
C
R
T
A
Y
I
D
G
S
L
------
27
PsiBlast_CBE
96.85
45%
-103
- C3 -
5EY9
4
FAA32_MYCMM
B:
[10-621]
------------------------
N
G
K
I
R
F
P
E
N
T
N
L
V
R
H
V
E
K
W
A
R
V
R
G
D
K
L
A
Y
R
F
L
D
F
S
T
E
R
D
G
V
E
R
-------
D
I
L
W
S
E
F
S
A
R
N
R
A
V
G
A
R
L
Q
-
Q
V
-
T
Q
P
G
D
R
I
A
I
L
C
P
Q
N
L
D
Y
L
I
S
F
F
G
A
L
Y
S
G
R
I
A
V
P
L
-
F
D
P
--
A
E
--
H
V
-
G
----
R
L
H
A
V
L
D
D
C
T
P
S
T
I
L
T
T
T
-
D
S
A
E
G
V
R
K
F
I
R
S
R
S
A
K
E
R
P
R
V
I
A
V
D
A
-------
V
---
P
T
E
V
A
S
-
T
W
Q
-
Q
P
E
A
N
E
L
T
T
A
Y
L
Q
Y
T
-----
V
P
S
G
V
Q
I
T
H
L
N
L
P
T
N
V
L
Q
-
V
L
N
A
L
-----
E
-
G
Q
E
G
D
R
G
V
S
W
L
P
F
F
H
D
M
G
L
I
T
-
V
L
L
---
A
S
V
L
G
H
-
S
F
T
F
M
T
P
A
A
F
V
-
R
R
P
G
R
W
I
R
E
L
A
--
R
K
P
G
E
T
G
G
T
F
S
A
-
A
P
N
F
A
F
E
H
A
A
M
R
G
V
P
-
R
D
D
E
P
P
-
L
D
L
S
N
-
V
-
K
G
I
L
N
G
S
-
E
P
V
S
P
A
S
M
R
K
F
F
K
A
F
E
P
Y
G
L
R
E
T
A
V
K
P
S
Y
G
L
A
E
A
T
L
F
V
S
T
T
P
M
D
E
V
P
T
V
I
H
V
D
R
D
E
L
N
K
Q
R
F
V
E
V
A
A
D
-
A
P
N
A
V
A
--
Q
V
S
A
G
K
V
G
V
D
E
W
A
V
I
V
D
T
E
T
--------
A
S
E
L
P
D
G
Q
I
G
E
I
W
L
H
G
N
N
L
G
I
G
Y
W
G
K
E
E
E
S
A
Q
T
F
R
N
I
L
K
S
R
V
P
E
-
S
H
A
E
G
A
P
D
D
G
L
----
W
V
R
T
G
D
Y
G
T
Y
F
-
K
G
H
L
Y
I
A
G
R
I
K
D
L
V
I
I
D
G
R
N
H
Y
P
Q
D
L
E
Y
T
A
Q
E
S
T
K
A
---
L
R
V
G
Y
V
A
A
F
S
V
P
A
N
QLP
Q
K
V
F
D
DPHAG
L
S
F
D
----------------
P
E
D
T
S
E
Q
L
V
I
V
G
E
R
A
A
G
T
-
H
--
K
L
E
Y
Q
P
I
A
-
D
D
I
R
A
A
I
A
V
G
H
G
V
T
V
R
D
V
L
L
V
S
A
G
T
I
P
R
T
S
S
G
K
I
G
R
R
A
C
R
T
A
Y
I
D
G
S
L
------
43
HHSearch
96.78
48%
-102
- C3 -
5D6J
2
?
A:
[11-618]
-------------------------
G
Q
I
K
F
P
D
G
S
S
I
V
A
H
V
E
R
W
A
K
V
R
G
D
K
L
A
Y
R
F
L
D
F
S
T
E
R
D
G
V
P
R
-------
D
L
T
W
A
Q
F
S
A
R
N
R
A
V
A
A
R
L
Q
-
Q
V
-
T
Q
P
G
D
R
V
A
I
L
C
P
Q
N
L
D
Y
L
V
A
F
F
G
A
L
Y
A
G
R
I
A
V
P
L
-
F
D
P
--
S
E
P
G
H
V
-
G
----
R
L
H
A
V
L
D
N
C
H
P
S
A
I
L
T
T
T
-
E
A
A
E
G
V
R
K
F
F
R
T
R
P
A
N
Q
R
P
R
V
I
A
V
D
A
-------
V
---
P
D
D
V
A
S
T
W
V
N
-
P
D
E
P
D
E
T
T
I
A
Y
L
Q
Y
T
S
G
S
T
R
I
P
T
G
V
Q
I
T
H
L
N
L
A
T
N
V
V
Q
-
V
I
E
A
L
-----
E
-
G
E
E
G
D
R
G
L
S
W
L
P
F
F
H
D
M
G
L
I
T
-
A
L
L
---
A
P
M
I
G
H
-
Y
F
T
F
M
T
P
A
A
F
V
-
R
R
P
E
R
W
I
R
E
L
A
--
R
K
E
G
D
T
G
G
T
I
S
V
-
A
P
N
F
A
F
D
H
A
A
A
R
G
V
P
K
P
G
S
P
-
P
-
L
D
L
S
N
-
V
K
A
V
L
N
-
G
S
-
E
P
I
S
A
A
T
V
R
R
F
N
E
A
F
G
P
F
G
F
P
P
K
A
I
K
P
S
Y
G
L
A
E
A
T
L
F
V
S
T
T
P
S
A
E
E
P
K
I
I
T
V
D
R
D
Q
L
N
S
G
R
I
V
E
V
D
A
D
-
S
P
K
A
V
A
--
Q
A
S
A
G
K
V
G
I
A
E
W
A
V
I
V
D
A
E
S
A
--------
T
E
L
P
D
G
Q
V
G
E
I
W
I
S
G
Q
N
M
G
T
G
Y
W
G
K
P
E
E
S
V
A
T
F
Q
N
I
L
K
S
R
T
N
-
P
S
H
A
E
G
A
T
D
D
A
T
----
W
V
R
T
G
D
Y
G
A
F
Y
-
D
G
D
L
Y
I
T
G
R
V
K
D
L
V
I
I
D
G
R
N
H
Y
P
Q
D
L
E
Y
S
A
Q
E
A
S
K
A
---
I
R
T
G
Y
V
A
A
F
S
V
P
A
N
----------------
Q
LP
D
E
V
F
E
NAHSG
I
K
R
D
P
D
D
T
S
E
Q
L
V
I
V
A
E
R
A
P
G
A
-
H
--
K
L
D
I
G
P
I
T
-
D
D
I
R
A
A
I
A
V
R
H
G
V
T
V
R
D
V
L
L
T
A
A
G
A
I
P
R
T
S
S
G
K
I
G
R
R
A
C
R
A
A
Y
L
D
G
S
L
R
A
----
2
PsiBlast_PDB
96.34
47%
-103
- C3 -
5D6J
2
?
A:
[10-616]
------------------------
D
G
Q
I
K
F
P
D
G
S
S
I
V
A
H
V
E
R
W
A
K
V
R
G
D
K
L
A
Y
R
F
L
D
F
S
T
E
R
D
G
V
P
R
-------
D
L
T
W
A
Q
F
S
A
R
N
R
A
V
A
A
R
L
Q
-
Q
V
-
T
Q
P
G
D
R
V
A
I
L
C
P
Q
N
L
D
Y
L
V
A
F
F
G
A
L
Y
A
G
R
I
A
V
P
L
-
F
D
P
--
S
E
P
G
H
V
-
G
----
R
L
H
A
V
L
D
N
C
H
P
S
A
I
L
T
T
T
-
E
A
A
E
G
V
R
K
F
F
R
T
R
P
A
N
Q
R
P
R
V
I
A
V
D
A
-------
V
---
P
D
D
V
A
S
-
T
W
V
N
P
D
E
P
D
E
T
T
I
A
Y
L
Q
Y
T
S
G
S
T
R
I
P
T
G
V
Q
I
T
H
L
N
L
A
T
N
V
V
Q
-
V
I
E
A
L
-----
E
-
G
E
E
G
D
R
G
L
S
W
L
P
F
F
H
D
M
G
L
I
T
-
A
L
L
---
A
P
M
I
G
H
-
Y
F
T
F
M
T
P
A
A
F
V
-
R
R
P
E
R
W
I
R
E
L
A
RK
E
G
-
D
-
T
G
G
T
I
S
V
-
A
P
N
F
A
F
D
H
A
A
A
R
G
V
P
-
K
P
G
S
P
P
-
L
D
L
S
N
-
V
-
K
A
V
L
N
G
S
-
E
P
I
S
A
A
T
V
R
R
F
N
E
A
F
G
P
F
G
F
P
P
K
A
I
K
P
S
Y
G
L
A
E
A
T
L
F
V
S
T
T
P
S
A
E
E
P
K
I
I
T
V
D
R
D
Q
L
N
S
G
R
I
V
E
V
D
A
D
-
S
P
K
A
V
A
--
Q
A
S
A
G
K
V
G
I
A
E
W
A
V
I
V
D
--------
A
E
S
A
T
E
L
P
D
G
Q
V
G
E
I
W
I
S
G
Q
N
M
G
T
G
Y
W
G
K
P
E
E
S
V
A
T
F
Q
N
I
L
K
S
-
R
T
N
P
S
H
A
E
G
A
T
D
D
A
T
----
W
V
R
T
G
D
Y
G
A
F
Y
-
D
G
D
L
Y
I
T
G
R
V
K
D
L
V
I
I
D
G
R
N
H
Y
P
Q
D
L
E
Y
S
A
Q
E
A
S
K
A
---
I
R
T
G
Y
V
A
A
F
S
V
P
A
N
QLP
D
E
V
F
E
NAHSG
I
K
R
D
----------------
P
D
D
T
S
E
Q
L
V
I
V
A
E
R
A
P
G
A
-
H
--
K
L
D
I
G
P
I
T
-
D
D
I
R
A
A
I
A
V
R
H
G
V
T
V
R
D
V
L
L
T
A
A
G
A
I
P
R
T
S
S
G
K
I
G
R
R
A
C
R
A
A
Y
L
D
G
S
L
------
25
PsiBlast_CBE
96.12
47%
-103
- C3 -
5EY8
1
?
C:
[10-616]
------------------------
D
G
Q
I
K
F
P
D
G
S
S
I
V
A
H
V
E
R
W
A
K
V
R
G
D
K
L
A
Y
R
F
L
D
F
S
T
E
R
D
G
V
P
R
-------
D
L
T
W
A
Q
F
S
A
R
N
R
A
V
A
A
R
L
Q
-
Q
V
-
T
Q
P
G
D
R
V
A
I
L
C
P
Q
N
L
D
Y
L
V
A
F
F
G
A
L
Y
A
G
R
I
A
V
P
L
-
F
D
P
--
S
E
--
H
V
-
G
----
R
L
H
A
V
L
D
N
C
H
P
S
A
I
L
T
T
T
-
E
A
A
E
G
V
R
K
F
F
R
T
R
P
A
N
Q
R
P
R
V
I
A
V
D
A
-------
V
---
P
D
D
V
A
S
-
T
W
V
N
P
D
E
P
D
E
T
T
I
A
Y
L
Q
Y
T
----
R
I
P
T
G
V
Q
I
T
H
L
N
L
A
T
N
V
V
Q
-
V
I
E
A
L
-----
E
-
G
E
E
G
D
R
G
L
S
W
L
P
F
F
H
D
M
G
L
I
T
-
A
L
L
---
A
P
M
I
G
H
-
Y
F
T
F
M
T
P
A
A
F
V
-
R
R
P
E
R
W
I
R
E
L
A
RK
E
G
-
D
-
T
G
G
T
I
S
V
-
A
P
N
F
A
F
D
H
A
A
A
R
G
V
P
-
K
P
G
S
P
P
-
L
D
L
S
N
-
V
-
K
A
V
L
N
G
S
-
E
P
I
S
A
A
T
V
R
R
F
N
E
A
F
G
P
F
G
F
P
P
K
A
I
K
P
S
Y
G
L
A
E
A
T
L
F
V
S
T
T
P
S
A
E
E
P
K
I
I
T
V
D
R
D
Q
L
N
S
G
R
I
V
E
V
D
A
D
-
S
P
K
A
V
A
--
Q
A
S
A
G
K
V
G
I
A
E
W
A
V
I
V
D
--------
A
E
S
A
T
E
L
P
D
G
Q
V
G
E
I
W
I
S
G
Q
N
M
G
T
G
Y
W
G
K
P
E
E
S
V
A
T
F
Q
N
I
L
K
S
-
R
T
N
P
S
H
A
E
G
A
T
D
D
A
T
----
W
V
R
T
G
D
Y
G
A
F
Y
-
D
G
D
L
Y
I
T
G
R
V
K
D
L
V
I
I
D
G
R
N
H
Y
P
Q
D
L
E
Y
S
A
Q
E
A
S
K
A
---
I
R
T
G
Y
V
A
A
F
S
V
P
A
N
QLP
D
E
V
F
E
NAHSGIKR
D
----------------
P
D
D
T
S
E
Q
L
V
I
V
A
E
R
A
P
G
------
L
D
I
G
P
I
T
-
D
D
I
R
A
A
I
A
V
R
H
G
V
T
V
R
D
V
L
L
T
A
A
G
A
I
P
R
T
S
S
G
K
I
G
R
R
A
C
R
A
A
Y
L
D
G
S
L
------
22
PsiBlast_CBE
95.84
47%
-107
- C3 -
5EY8
2
?
F:
[10-616]
------------------------
D
G
Q
I
K
F
P
D
G
S
S
I
V
A
H
V
E
R
W
A
K
V
R
G
D
K
L
A
Y
R
F
L
D
F
S
T
E
R
D
G
V
P
R
-------
D
L
T
W
A
Q
F
S
A
R
N
R
A
V
A
A
R
L
Q
-
Q
V
-
T
Q
P
G
D
R
V
A
I
L
C
P
Q
N
L
D
Y
L
V
A
F
F
G
A
L
Y
A
G
R
I
A
V
P
L
-
F
D
P
--
S
E
P
G
H
V
-
G
----
R
L
H
A
V
L
D
N
C
H
P
S
A
I
L
T
T
T
-
E
A
A
E
G
V
R
K
F
F
R
T
R
P
A
N
Q
R
P
R
V
I
A
V
D
A
-------
V
---
P
D
D
V
A
S
-
T
W
V
N
P
D
E
P
D
E
T
T
I
A
Y
L
Q
Y
T
S
---
R
I
P
T
G
V
Q
I
T
H
L
N
L
A
T
N
V
V
Q
-
V
I
E
A
L
-----
E
-
G
E
E
G
D
R
G
L
S
W
L
P
F
F
H
D
M
G
L
I
T
-
A
L
L
---
A
P
M
I
G
H
-
Y
F
T
F
M
T
P
A
A
F
V
-
R
R
P
E
R
W
I
R
E
L
A
RK
E
G
-
D
-
T
G
G
T
I
S
V
-
A
P
N
F
A
F
D
H
A
A
A
R
G
V
P
-
K
P
G
S
P
P
-
L
D
L
S
N
-
V
-
K
A
V
L
N
G
S
-
E
P
I
S
A
A
T
V
R
R
F
N
E
A
F
G
P
F
G
F
P
P
K
A
I
K
P
S
Y
G
L
A
E
A
T
L
F
V
S
T
T
P
S
A
E
E
P
K
I
I
T
V
D
R
D
Q
L
N
S
G
R
I
V
E
V
D
A
D
-
S
P
K
A
V
A
--
Q
A
S
A
G
K
V
G
I
A
E
W
A
V
I
V
D
--------
A
E
S
A
T
E
L
P
D
G
Q
V
G
E
I
W
I
S
G
Q
N
M
G
T
G
Y
W
G
K
P
E
E
S
V
A
T
F
Q
N
I
L
K
S
-
R
T
N
P
S
H
A
E
G
A
T
D
D
A
T
----
W
V
R
T
G
D
Y
G
A
F
Y
-
D
G
D
L
Y
I
T
G
R
V
K
D
L
V
I
I
D
G
R
N
H
Y
P
Q
D
L
E
Y
S
A
Q
E
A
S
K
A
---
I
R
T
G
Y
V
A
A
F
S
V
P
A
N
QLP
D
E
V
F
E
NAHSGIKR
D
----------------
P
D
D
T
S
E
Q
L
V
I
V
A
E
R
A
P
--------
D
I
G
P
I
T
-
D
D
I
R
A
A
I
A
V
R
H
G
V
T
V
R
D
V
L
L
T
A
A
G
A
I
P
R
T
S
S
G
K
I
G
R
R
A
C
R
A
A
Y
L
D
G
S
L
------
1
PsiBlast_PDB
95.78
47%
-103
- C3 -
5EY8
1
?
A:
[11-616]
-------------------------
G
Q
I
K
F
P
D
G
S
S
I
V
A
H
V
E
R
W
A
K
V
R
G
D
K
L
A
Y
R
F
L
D
F
S
T
E
R
D
G
V
P
R
-------
D
L
T
W
A
Q
F
S
A
R
N
R
A
V
A
A
R
L
Q
-
Q
V
-
T
Q
P
G
D
R
V
A
I
L
C
P
Q
N
L
D
Y
L
V
A
F
F
G
A
L
Y
A
G
R
I
A
V
P
L
-
F
D
P
--
S
E
P
G
H
V
-
G
----
R
L
H
A
V
L
D
N
C
H
P
S
A
I
L
T
T
T
-
E
A
A
E
G
V
R
K
F
F
R
T
R
P
A
N
Q
R
P
R
V
I
A
V
D
A
-------
V
---
P
D
D
V
A
S
-
T
W
V
N
P
D
E
P
D
E
T
T
I
A
Y
L
Q
Y
T
S
---
R
I
P
T
G
V
Q
I
T
H
L
N
L
A
T
N
V
V
Q
-
V
I
E
A
L
-----
E
-
G
E
E
G
D
R
G
L
S
W
L
P
F
F
H
D
M
G
L
I
T
-
A
L
L
---
A
P
M
I
G
H
-
Y
F
T
F
M
T
P
A
A
F
V
-
R
R
P
E
R
W
I
R
E
L
A
RK
E
G
-
D
-
T
G
G
T
I
S
V
-
A
P
N
F
A
F
D
H
A
A
A
R
G
V
P
-
K
P
G
S
P
P
-
L
D
L
S
N
-
V
-
K
A
V
L
N
G
S
-
E
P
I
S
A
A
T
V
R
R
F
N
E
A
F
G
P
F
G
F
P
P
K
A
I
K
P
S
Y
G
L
A
E
A
T
L
F
V
S
T
T
P
S
A
E
E
P
K
I
I
T
V
D
R
D
Q
L
N
S
G
R
I
V
E
V
D
A
D
-
S
P
K
A
V
A
--
Q
A
S
A
G
K
V
G
I
A
E
W
A
V
I
V
D
--------
A
E
S
A
T
E
L
P
D
G
Q
V
G
E
I
W
I
S
G
Q
N
M
G
T
G
Y
W
G
K
P
E
E
S
V
A
T
F
Q
N
I
L
K
S
-
R
T
N
P
S
H
A
E
G
A
T
D
D
A
T
----
W
V
R
T
G
D
Y
G
A
F
Y
-
D
G
D
L
Y
I
T
G
R
V
K
D
L
V
I
I
D
G
R
N
H
Y
P
Q
D
L
E
Y
S
A
Q
E
A
S
K
A
---
I
R
T
G
Y
V
A
A
F
S
V
P
A
N
QLP
D
E
V
F
E
NAHSG
I
K
R
D
----------------
P
D
D
T
S
E
Q
L
V
I
V
A
E
R
A
P
--------
D
I
G
P
I
T
-
D
D
I
R
A
A
I
A
V
R
H
G
V
T
V
R
D
V
L
L
T
A
A
G
A
I
P
R
T
S
S
G
K
I
G
R
R
A
C
R
A
A
Y
L
D
G
S
L
------
24
PsiBlast_CBE
95.63
47%
-105
- C3 -
5EY8
1
?
D:
[10-616]
------------------------
D
G
Q
I
K
F
P
D
G
S
S
I
V
A
H
V
E
R
W
A
K
V
R
G
D
K
L
A
Y
R
F
L
D
F
S
T
E
R
D
G
V
P
R
-------
D
L
T
W
A
Q
F
S
A
R
N
R
A
V
A
A
R
L
Q
-
Q
V
-
T
Q
P
G
D
R
V
A
I
L
C
P
Q
N
L
D
Y
L
V
A
F
F
G
A
L
Y
A
G
R
I
A
V
P
L
-
F
D
P
--
S
E
--
H
V
-
G
----
R
L
H
A
V
L
D
N
C
H
P
S
A
I
L
T
T
T
-
E
A
A
E
G
V
R
K
F
F
R
T
R
P
A
N
Q
R
P
R
V
I
A
V
D
A
-------
V
---
P
D
D
V
A
S
-
T
W
V
N
P
D
E
P
D
E
T
T
I
A
Y
L
Q
Y
T
S
-
S
T
R
I
P
T
G
V
Q
I
T
H
L
N
L
A
T
N
V
V
Q
-
V
I
E
A
L
-----
E
-
G
E
E
G
D
R
G
L
S
W
L
P
F
F
H
D
M
G
L
I
T
-
A
L
L
---
A
P
M
I
G
H
-
Y
F
T
F
M
T
P
A
A
F
V
-
R
R
P
E
R
W
I
R
E
L
A
RK
E
G
-
D
-
T
G
G
T
I
S
V
-
A
P
N
F
A
F
D
H
A
A
A
R
G
V
P
-
K
P
G
S
P
P
-
L
D
L
S
N
-
V
-
K
A
V
L
N
G
S
-
E
P
I
S
A
A
T
V
R
R
F
N
E
A
F
G
P
F
G
F
P
P
K
A
I
K
P
S
Y
G
L
A
E
A
T
L
F
V
S
T
T
P
S
A
E
E
P
K
I
I
T
V
D
R
D
Q
L
N
S
G
R
I
V
E
V
D
A
D
-
S
P
K
A
V
A
--
Q
A
S
A
G
K
V
G
I
A
E
W
A
V
I
V
D
--------
A
E
S
A
T
E
L
P
D
G
Q
V
G
E
I
W
I
S
G
Q
N
M
G
T
G
Y
W
G
K
P
E
E
S
V
A
T
F
Q
N
I
L
K
S
-
R
T
N
P
S
H
A
E
G
A
T
D
D
A
T
----
W
V
R
T
G
D
Y
G
A
F
Y
-
D
G
D
L
Y
I
T
G
R
V
K
D
L
V
I
I
D
G
R
N
H
Y
P
Q
D
L
E
Y
S
A
Q
E
A
S
K
A
---
I
R
T
G
Y
V
A
A
F
S
V
P
A
N
QLP
D
E
V
F
E
NAHSGIKR
D
----------------
P
D
D
T
S
E
Q
L
V
I
V
A
E
R
A
---------
D
I
G
P
I
T
-
D
D
I
R
A
A
I
A
V
R
H
G
V
T
V
R
D
V
L
L
T
A
A
G
A
I
P
R
T
S
S
G
K
I
G
R
R
A
C
R
A
A
Y
L
D
G
S
L
------
26
PsiBlast_CBE
95.43
47%
-102
- C3 -
5EY8
1
?
B:
[12-616]
--------------------------
Q
I
K
F
P
D
G
S
S
I
V
A
H
V
E
R
W
A
K
V
R
G
D
K
L
A
Y
R
F
L
D
F
S
T
---
G
V
P
R
-------
D
L
T
W
A
Q
F
S
A
R
N
R
A
V
A
A
R
L
Q
-
Q
V
-
T
Q
P
G
D
R
V
A
I
L
C
P
Q
N
L
D
Y
L
V
A
F
F
G
A
L
Y
A
G
R
I
A
V
P
L
-
F
D
P
--
S
--
G
H
V
-
G
----
R
L
H
A
V
L
D
N
C
H
P
S
A
I
L
T
T
T
-
E
A
A
E
G
V
R
K
F
F
R
T
R
P
A
N
Q
R
P
R
V
I
A
V
D
A
-------
V
---
P
D
D
V
A
S
-
T
W
V
N
P
D
E
P
D
E
T
T
I
A
Y
L
Q
Y
T
S
G
S
T
R
I
P
T
G
V
Q
I
T
H
L
N
L
A
T
N
V
V
Q
-
V
I
E
A
L
-----
E
-
G
E
E
G
D
R
G
L
S
W
L
P
F
F
H
D
M
G
L
I
T
-
A
L
L
---
A
P
M
I
G
H
-
Y
F
T
F
M
T
P
A
A
F
V
-
R
R
P
E
R
W
I
R
E
L
A
RK
E
G
-
D
-
T
G
G
T
I
S
V
-
A
P
N
F
A
F
D
H
A
A
A
R
G
V
P
-
K
P
G
S
P
P
-
L
D
L
S
N
-
V
-
K
A
V
L
N
G
S
-
E
P
I
S
A
A
T
V
R
R
F
N
E
A
F
G
P
F
G
F
P
P
K
A
I
K
P
S
Y
G
L
A
E
A
T
L
F
V
S
T
T
P
S
A
E
E
P
K
I
I
T
V
D
R
D
Q
L
N
S
G
R
I
V
E
V
D
A
D
-
S
P
K
A
V
A
--
Q
A
S
A
G
K
V
G
I
A
E
W
A
V
I
V
D
--------
A
E
S
A
T
E
L
P
D
G
Q
V
G
E
I
W
I
S
G
Q
N
M
G
T
G
Y
W
G
K
P
E
E
S
V
A
T
F
Q
N
I
L
K
S
-
R
T
N
P
S
H
A
E
G
A
T
D
D
A
T
----
W
V
R
T
G
D
Y
G
A
F
Y
-
D
G
D
L
Y
I
T
G
R
V
K
D
L
V
I
I
D
G
R
N
H
Y
P
Q
D
L
E
Y
S
A
Q
E
A
S
K
A
---
I
R
T
G
Y
V
A
A
F
S
V
P
A
N
QLP
D
E
V
F
E
NAHSGIKR
D
----------------
P
D
D
T
S
-
Q
L
V
I
V
A
E
R
---------
L
D
I
G
P
I
T
-
D
D
I
R
A
A
I
A
V
R
H
G
V
T
V
R
D
V
L
L
T
A
A
G
A
I
P
R
T
S
S
G
K
I
G
R
R
A
C
R
A
A
Y
L
D
G
S
L
------
3
PsiBlast_PDB
94.97
46%
-102
- C3 -
5ICR
3
?
A:
[27-636]
---------------------
F
I
K
D
G
Q
I
K
F
P
D
G
S
S
I
V
A
H
V
E
R
W
A
K
V
R
G
D
K
L
A
Y
R
F
L
D
F
S
T
E
R
D
G
V
P
R
-------
D
L
T
W
A
Q
F
S
A
R
N
R
A
V
A
A
R
L
Q
-
Q
V
-
T
Q
P
G
D
R
V
A
I
L
C
P
Q
N
L
D
Y
L
V
A
F
F
G
A
L
Y
A
G
R
I
A
V
P
L
-
F
D
P
--
S
E
P
G
H
V
-
G
----
R
L
H
A
V
L
D
N
C
H
P
S
A
I
L
T
T
T
-
E
A
A
E
G
V
R
K
F
F
R
T
R
P
A
N
Q
R
P
R
V
I
A
V
D
A
-------
V
---
P
D
D
V
A
S
-
T
W
V
N
P
D
E
P
D
E
T
T
I
A
Y
L
Q
Y
T
S
---
R
I
P
T
G
V
Q
I
T
H
L
N
L
A
T
N
V
V
Q
-
V
I
E
A
L
-----
E
-
G
E
E
G
D
R
G
L
S
W
L
P
F
F
H
D
M
G
L
I
T
-
A
L
L
---
A
P
M
I
G
H
-
Y
F
T
F
M
T
P
A
A
F
V
-
R
R
P
E
R
W
I
R
E
L
A
RK
E
G
-
D
-
T
G
G
T
I
S
V
-
A
P
N
F
A
F
D
H
A
A
A
R
G
V
P
-
K
P
G
S
P
P
-
L
D
L
S
N
-
V
-
K
A
V
L
N
G
S
-
E
P
I
S
A
A
T
V
R
R
F
N
E
A
F
G
P
F
G
F
P
P
K
A
I
K
P
S
Y
G
L
A
E
A
T
L
F
V
S
T
T
P
S
A
E
E
P
K
I
I
T
V
D
R
D
Q
L
N
S
G
R
I
V
E
V
D
A
D
-
S
P
K
A
V
A
--
Q
A
S
A
G
K
V
G
I
A
E
W
A
V
I
V
D
--------
A
E
S
A
T
E
L
P
D
G
Q
V
G
E
I
W
I
S
G
Q
N
M
G
T
G
Y
W
G
K
P
E
E
S
V
A
T
F
Q
N
I
L
K
S
-
R
T
N
P
S
H
A
E
G
A
T
D
D
A
T
----
W
V
R
T
G
D
Y
G
A
F
Y
-
D
G
D
L
Y
I
T
G
R
V
K
D
L
V
I
I
D
G
R
N
H
Y
P
Q
D
L
E
Y
S
A
Q
E
A
S
K
A
---
I
R
T
G
Y
V
A
A
F
S
V
P
A
N
QLPDE-----------
D
----------------
P
D
D
T
S
E
Q
L
V
I
V
A
E
R
A
P
------
K
L
D
I
G
P
I
T
-
D
D
I
R
A
A
I
A
V
R
H
G
V
T
V
R
D
V
L
L
T
A
A
G
A
I
P
R
T
S
S
G
K
I
G
R
R
A
C
R
A
A
Y
L
D
G
S
L
------
21
PsiBlast_CBE
94.85
47%
-106
- C3 -
5EY8
1
?
H:
[10-616]
------------------------
D
G
Q
I
K
F
----
S
I
V
A
H
V
E
R
W
A
K
V
R
G
D
K
-
A
Y
R
F
L
D
F
S
T
E
R
D
G
V
P
R
-------
D
L
T
W
A
Q
F
S
A
R
N
R
A
V
A
A
R
L
Q
-
Q
V
-
T
Q
P
G
D
R
V
A
I
L
C
P
Q
N
L
D
Y
L
V
A
F
F
G
A
L
Y
A
G
R
I
A
V
P
L
-
F
D
P
--
S
E
--
H
V
-
G
----
R
L
H
A
V
L
D
N
C
H
P
S
A
I
L
T
T
T
-
E
A
A
E
G
V
R
K
F
F
R
T
R
P
A
N
Q
R
P
R
V
I
A
V
D
A
-------
V
---
P
D
D
V
A
S
-
T
W
V
N
P
D
E
P
D
E
T
T
I
A
Y
L
Q
Y
T
S
G
--
R
I
P
T
G
V
Q
I
T
H
L
N
L
A
T
N
V
V
Q
-
V
I
E
A
L
-----
E
-
G
E
E
G
D
R
G
L
S
W
L
P
F
F
H
D
M
G
L
I
T
-
A
L
L
-----
M
I
G
H
-
Y
F
T
F
M
T
P
A
A
F
V
-
R
R
P
E
R
W
I
R
E
L
A
RK
E
G
-
D
-
T
--
T
I
S
V
-
A
P
N
F
A
F
D
H
A
A
A
R
G
V
P
-
K
P
G
S
P
P
-
L
D
L
S
N
-
V
-
K
A
V
L
N
G
S
-
E
P
I
S
A
A
T
V
R
R
F
N
E
A
F
G
P
F
G
F
P
P
K
A
I
K
P
S
Y
G
L
A
E
A
T
L
F
V
S
T
T
P
S
A
E
E
P
K
I
I
T
V
D
R
D
Q
L
N
S
G
R
I
V
E
V
D
A
D
-
S
P
K
A
V
A
--
Q
A
S
A
G
K
V
G
I
A
E
W
A
V
I
V
D
--------
A
E
S
A
T
E
L
P
D
G
Q
V
G
E
I
W
I
S
G
Q
N
M
G
T
G
Y
W
G
K
P
E
E
S
V
A
T
F
Q
N
I
L
K
S
-
R
T
N
P
S
H
A
E
G
A
T
D
D
A
T
----
W
V
R
T
G
D
Y
G
A
F
Y
-
D
G
D
L
Y
I
T
G
R
V
K
D
L
V
I
I
D
G
R
N
H
Y
P
Q
D
L
E
Y
S
A
Q
E
A
S
K
A
---
I
R
T
G
Y
V
A
A
F
S
V
P
A
N
QLP
D
E
V
F
E
NAHSGIKR
D
----------------
P
D
D
T
S
E
Q
L
V
I
V
A
E
R
A
--
A
-
H
--
K
L
D
I
G
P
I
T
-
D
D
I
R
A
A
I
A
V
R
H
G
V
T
V
R
D
V
L
L
T
A
A
G
A
I
P
R
T
S
S
G
K
I
G
R
R
A
C
R
A
A
Y
L
D
G
S
L
------
23
PsiBlast_CBE
94.40
47%
-103
- C3 -
5EY8
2
?
E:
[12-616]
--------------------------
Q
I
K
F
P
----
I
V
A
H
V
E
R
W
A
K
V
R
G
D
K
L
A
Y
R
F
L
D
F
S
T
E
R
D
G
V
P
R
-------
D
L
T
W
A
Q
F
S
A
R
N
R
A
V
A
A
R
L
Q
-
Q
V
-
T
Q
P
G
D
R
V
A
I
L
C
P
Q
N
L
D
Y
L
V
A
F
F
G
A
L
Y
A
G
R
I
A
V
P
L
-
F
D
P
--
S
E
--
H
V
-
G
----
R
L
H
A
V
L
D
N
C
H
P
S
A
I
L
T
T
T
-
E
A
A
E
G
V
R
K
F
F
R
T
R
P
A
N
Q
R
P
R
V
I
A
V
D
A
-------
V
---
P
D
D
V
A
S
-
T
W
V
N
P
D
E
P
D
E
T
T
I
A
Y
L
Q
Y
T
S
G
--
R
I
P
T
G
V
Q
I
T
H
L
N
L
A
T
N
V
V
Q
-
V
I
E
A
L
-----
E
-
G
E
E
G
D
R
G
L
S
W
L
P
F
F
H
D
M
G
L
I
T
-
A
L
L
---
A
P
M
I
G
H
-
Y
F
T
F
M
T
P
A
A
F
V
-
R
R
P
E
R
W
I
R
E
L
A
RK
E
G
-
D
-
T
G
G
T
I
S
V
-
A
P
N
F
A
F
D
H
A
A
A
R
G
V
P
-
K
P
G
S
P
P
-
L
D
L
S
N
-
V
-
K
A
V
L
N
G
S
-
E
P
I
S
A
A
T
V
R
R
F
N
E
A
F
G
P
F
G
F
P
P
K
A
I
K
P
S
Y
G
L
A
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A
T
L
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V
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T
T
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S
A
E
E
P
K
I
I
T
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D
R
D
Q
L
N
S
G
R
I
V
E
V
D
A
D
-
S
P
K
A
V
A
--
Q
A
S
A
G
K
V
G
I
A
E
W
A
V
I
V
D
--------
A
E
S
A
T
E
L
P
D
G
Q
V
G
E
I
W
I
S
G
Q
N
M
G
T
G
Y
W
G
K
P
E
E
S
V
A
T
F
Q
N
I
L
K
S
-
R
T
N
P
S
H
A
E
G
A
T
D
D
A
T
----
W
V
R
T
G
D
Y
G
A
F
Y
-
D
G
D
L
Y
I
T
G
R
V
K
D
L
V
I
I
D
G
R
N
H
Y
P
Q
D
L
E
Y
S
A
Q
E
A
S
K
A
---
I
R
T
G
Y
V
A
A
F
S
V
P
A
N
QLP
D
E
V
F
E
NAHSG
I
K
R
D
----------------
P
D
D
T
S
E
Q
L
V
I
V
A
E
R
A
--------
L
D
I
G
P
I
T
-
D
D
I
R
A
A
I
A
V
R
H
G
V
T
V
R
D
V
L
L
T
A
A
G
A
I
P
R
T
S
S
G
K
I
G
R
R
A
C
R
A
A
Y
L
D
G
S
L
------
5
PsiBlast_PDB
84.13
44%
-104
- C3 -
5D6N
-
?
A:
[3-482]
-----------------
F
H
N
P
F
I
K
D
G
Q
I
K
F
P
D
G
S
S
I
V
A
H
V
E
R
W
A
K
V
R
G
D
K
L
A
Y
R
F
L
D
F
S
T
E
R
D
G
V
P
R
-------
D
L
T
W
A
Q
F
S
A
R
N
R
A
V
A
A
R
L
Q
-
Q
V
-
T
Q
P
G
D
R
V
A
I
L
C
P
Q
N
L
D
Y
L
V
A
F
F
G
A
L
Y
A
G
R
I
A
V
P
L
-
F
D
P
--
S
E
P
G
H
V
-
G
----
R
L
H
A
V
L
D
N
C
H
P
S
A
I
L
T
T
T
-
E
A
A
E
G
V
R
K
F
F
R
T
R
P
A
N
Q
R
P
R
V
I
A
V
D
A
-------
V
---
P
D
D
V
A
S
-
T
W
V
N
P
D
E
P
D
E
T
T
I
A
Y
L
Q
Y
T
S
G
S
T
R
I
P
T
G
V
Q
I
T
H
L
N
L
A
T
N
V
V
Q
-
V
I
E
A
L
-----
E
-
G
E
E
G
D
R
G
L
S
W
L
P
F
F
H
D
M
G
L
I
T
-
A
L
L
---
A
P
M
I
G
H
-
Y
F
T
F
M
T
P
A
A
F
V
-
R
R
P
E
R
W
I
R
E
L
A
RK
E
G
-
D
-
T
G
G
T
I
S
V
-
A
P
N
F
A
F
D
H
A
A
A
R
G
V
P
-
K
P
G
S
P
P
-
L
D
L
S
N
-
V
-
K
A
V
L
N
G
S
-
E
P
I
S
A
A
T
V
R
R
F
N
E
A
F
G
P
F
G
F
P
P
K
A
I
K
P
S
Y
G
L
A
E
A
T
L
F
V
S
T
T
P
S
A
E
E
P
K
I
I
T
V
D
R
D
Q
L
N
S
G
R
I
V
E
V
D
A
D
-
S
P
K
A
V
A
--
Q
A
S
A
G
K
V
G
I
A
E
W
A
V
I
V
D
--------
A
E
S
A
T
E
L
P
D
G
Q
V
G
E
I
W
I
S
G
Q
N
M
G
T
G
Y
W
G
K
P
E
E
S
V
A
T
F
Q
N
I
L
K
S
-
R
T
N
P
S
H
A
E
G
A
T
D
D
A
T
----
W
V
R
T
G
D
Y
G
A
F
Y
-
D
G
D
L
Y
I
T
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
81.23
31%
-93
- C3 -
3KXW
1
?
A:
[15-572]
------------------------------------------------
D
V
V
R
L
R
A
L
-
H
S
P
N
K
K
S
C
T
F
L
N
KE
L
E
E
T
M
T
Y
E
Q
L
D
Q
H
A
K
A
I
A
A
T
L
Q
A
E
G
-
A
K
P
G
D
R
V
L
L
L
F
A
P
G
L
P
L
I
Q
A
F
L
G
C
L
Y
A
G
C
I
A
V
P
I
-
Y
P
P
--
A
Q
E
K
L
L
-
D
----
K
A
Q
R
I
V
T
N
S
K
P
V
I
V
L
M
I
A
D
H
I
K
K
F
T
A
-----
N
P
K
F
L
K
I
P
A
I
A
L
E
S
-------
I
---
E
L
N
R
S
S
-
S
W
Q
-
P
T
S
I
K
S
N
D
I
A
F
L
Q
Y
T
S
G
S
T
M
H
P
K
G
V
M
V
S
H
H
N
L
L
D
N
L
N
K
-
I
F
T
S
F
-----
H
M
-
N
D
E
T
I
I
F
S
W
L
P
P
H
H
D
M
G
L
I
G
-
C
I
L
---
T
P
I
Y
G
G
I
Q
A
I
M
M
S
P
F
S
F
L
-
Q
N
P
L
S
W
L
K
H
I
T
--
K
Y
-
K
A
T
---
I
S
G
-
S
P
N
F
A
Y
D
Y
C
V
K
R
I
R
E
-
E
K
K
E
-
G
-
L
D
L
S
S
W
V
-
T
A
F
N
-
G
A
-
E
P
V
R
E
E
T
M
E
H
F
Y
Q
A
F
K
E
F
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F
R
K
E
A
F
Y
P
C
Y
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L
A
E
A
T
L
L
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T
G
G
T
P
G
S
S
Y
K
T
L
T
L
A
K
E
Q
F
-
Q
D
H
R
V
H
F
A
D
D
N
S
P
G
S
Y
K
--
L
V
S
S
G
N
P
I
Q
E
V
--
K
I
I
D
P
D
T
L
----
I
P
C
D
F
D
----
Q
V
G
E
I
W
V
Q
S
N
S
V
A
K
G
Y
W
N
Q
P
E
E
T
R
H
A
F
A
G
K
I
K
D
-------
D
---
A
I
-------
Y
L
R
T
G
D
L
G
F
L
H
-
E
N
E
L
Y
V
T
G
R
I
K
D
L
I
I
I
Y
G
K
N
H
Y
P
Q
D
I
E
F
S
L
M
H
S
P
L
H
---
H
V
L
G
K
C
A
A
F
V
I
------------------------------------
Q
E
E
H
E
Y
K
L
T
V
M
C
E
V
K
N
R
F
-
M
--
D
D
V
A
Q
D
N
L
F
N
E
I
F
E
L
V
Y
E
N
H
Q
L
E
V
H
T
I
V
L
I
P
L
K
A
M
P
H
T
T
S
G
K
I
R
R
N
F
C
R
K
H
L
L
D
K
T
L
P
I
----
58
HHSearch
80.87
32%
-92
- C3 -
3KXW
1
?
A:
[11-571]
---------------------------------
Q
S
L
V
D
V
V
R
L
R
A
L
H
S
P
N
K
K
S
C
T
F
L
N
K
E
-----
L
E
E
-------
T
M
T
Y
E
Q
L
D
Q
H
A
K
A
I
A
A
T
L
Q
-
A
E
G
A
K
P
G
D
R
V
L
L
L
F
A
P
G
L
P
L
I
Q
A
F
L
G
C
L
Y
A
G
C
I
A
V
P
I
-
Y
P
P
--
A
Q
E
K
L
L
-
D
----
K
A
Q
R
I
V
T
N
S
K
P
V
I
V
L
M
I
A
-
D
H
I
K
K
F
T
A
----
N
P
K
F
L
K
I
P
A
I
A
L
E
S
-------
I
---
E
L
N
R
S
S
-
S
W
Q
-
P
T
S
I
K
S
N
D
I
A
F
L
Q
Y
T
S
G
S
T
M
H
P
K
G
V
M
V
S
H
H
N
L
L
D
N
L
N
K
-
I
F
T
S
F
-----
H
-
M
N
D
E
T
I
I
F
S
W
L
P
P
H
H
D
M
G
L
I
G
C
I
L
T
---
P
I
Y
G
G
I
-
Q
A
I
M
M
S
P
F
S
F
L
-
Q
N
P
L
S
W
L
K
H
I
T
--
K
----
Y
K
A
T
I
S
G
-
S
P
N
F
A
Y
D
Y
C
V
K
R
I
R
E
-
E
K
K
E
-
G
-
L
D
L
S
S
-
W
V
T
A
F
N
-
G
A
-
E
P
V
R
E
E
T
M
E
H
F
Y
Q
A
F
K
E
F
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F
R
K
E
A
F
Y
P
C
Y
G
L
A
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A
T
L
L
V
T
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G
T
P
G
S
S
Y
K
T
L
T
L
A
K
E
Q
F
Q
D
H
R
V
H
F
A
D
D
N
-
S
P
G
S
Y
K
--
L
V
S
S
G
N
P
I
--
Q
E
V
K
I
I
D
P
D
T
L
--------
I
P
C
D
F
D
Q
V
G
E
I
W
V
Q
S
N
S
V
A
K
G
Y
W
N
Q
P
E
E
T
R
H
A
F
A
G
K
I
K
D
D
-------------
A
I
----
Y
L
R
T
G
D
L
G
F
L
H
-
E
N
E
L
Y
V
T
G
R
I
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D
L
I
I
I
Y
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K
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Y
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Q
D
I
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F
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L
-
M
H
S
P
L
HHV
L
G
K
C
--
A
A
F
V
I
Q
E
E
------------------------------------
H
E
Y
K
L
T
V
M
C
E
V
K
N
R
F
M
D
--
D
V
A
Q
D
N
L
F
-
N
E
I
F
E
L
V
Y
E
N
H
Q
L
E
V
H
T
I
V
L
I
P
L
K
A
M
P
H
T
T
S
G
K
I
R
R
N
F
C
R
K
H
L
L
D
K
T
L
P
-----
7
PsiBlast_PDB
72.13
36%
-100
- C3 -
3T5A
-
FAA28_MYCTU
A:
[22-459]
---------------------------------------------------
A
F
T
F
M
D
Y
E
Q
D
W
D
G
V
A
I
-------
T
L
T
W
S
Q
L
Y
R
R
T
L
N
V
A
Q
E
L
S
-
R
C
-
G
S
T
G
D
R
V
V
I
S
A
P
Q
G
L
E
Y
V
V
A
F
L
G
A
L
Q
A
G
R
I
A
V
P
L
-
S
V
P
--
Q
G
G
V
T
D
-
E
----
R
S
D
S
V
L
S
D
S
S
P
V
A
I
L
T
T
S
-
S
A
V
D
D
V
V
Q
H
V
A
------
P
P
S
I
I
E
V
D
L
-------
L
---
D
L
D
A
P
----
T
-
F
K
E
D
E
Y
P
S
T
A
Y
L
Q
Y
T
------
P
A
G
V
V
M
S
H
Q
N
V
R
V
N
F
E
Q
-
L
M
S
G
Y
FADTD
G
I
P
P
P
N
S
A
L
V
S
W
L
P
F
Y
H
D
M
G
L
V
I
G
I
C
A
---
P
I
L
G
G
Y
-
P
A
V
L
T
S
P
V
S
F
L
-
Q
R
P
A
R
W
M
H
L
M
A
--
S
D
-
F
---
H
A
F
S
A
-
A
P
N
F
A
F
E
L
A
A
R
R
T
T
D
-
D
D
M
A
-
G
-
R
D
L
G
N
-
I
-
L
T
I
L
S
G
S
-
E
R
V
Q
A
A
T
I
K
R
F
A
D
R
F
A
R
F
N
L
Q
E
R
V
I
R
P
S
Y
W
L
A
E
A
T
V
Y
V
A
T
S
K
P
G
Q
P
P
E
T
V
D
F
D
T
E
S
L
S
A
G
H
A
K
P
C
A
G
G
-
G
A
T
S
L
I
--
S
Y
---
M
L
P
R
S
P
I
V
R
I
V
D
S
D
T
--------
C
I
E
C
P
D
G
T
V
G
E
I
W
V
H
G
D
N
V
A
N
G
Y
W
Q
K
P
D
E
S
E
R
T
F
G
G
K
I
V
T
P
------
S
P
G
T
P
-
E
G
P
----
W
L
R
T
G
D
S
G
F
V
T
-
D
G
K
M
F
I
I
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
70.37
32%
-80
- C3 -
3PBK
1
?
A:
[73-560]
----------------------------------------------------------------------------------------------------
G
D
R
V
A
L
I
A
E
T
S
S
E
F
V
E
A
F
F
A
C
Q
Y
A
G
L
V
A
V
P
L
-
A
I
P
--
M
G
V
G
Q
R
-
D
S
W
S
A
K
L
Q
G
L
L
A
S
C
Q
P
A
A
I
I
T
G
D
-
E
W
L
P
L
V
N
A
A
T
H
D
N
P
E
L
H
V
L
S
H
A
W
F
K
A
-------
L
---
P
E
A
D
V
A
-
L
Q
R
-
P
V
P
N
D
I
---
A
Y
L
Q
Y
T
S
G
S
T
R
F
P
R
G
V
I
I
T
H
R
E
V
M
A
N
L
R
A
-
I
S
H
D
G
-----
I
K
L
R
P
G
D
R
C
V
S
W
L
P
F
Y
H
D
M
G
L
---
V
G
F
L
L
T
P
V
A
T
Q
L
-
S
V
D
Y
L
R
T
Q
D
F
A
-
M
R
P
L
Q
W
L
K
L
I
S
--
K
N
-
R
G
T
---
V
S
V
-
A
P
P
F
G
Y
E
L
C
Q
R
R
V
N
E
-
K
D
L
A
-
E
-
L
D
L
S
C
-
W
R
V
A
G
I
-
G
A
-
E
P
I
S
A
E
Q
L
H
Q
F
A
E
C
F
R
Q
V
N
F
D
N
K
T
F
M
P
C
Y
G
L
A
E
N
A
L
A
V
S
F
S
D
E
A
S
G
V
V
V
N
E
V
D
R
D
I
L
E
Y
-
Q
G
K
A
V
A
P
G
-
A
E
T
R
A
V
S
T
F
V
N
C
G
K
A
L
---------
P
E
H
G
I
E
I
R
N
E
A
G
M
P
V
A
E
R
V
V
G
H
I
C
I
S
G
P
S
L
M
S
G
Y
F
G
-----------------------
D
Q
V
S
Q
D
E
I
A
A
TG
W
L
D
T
G
D
L
G
Y
L
L
-
D
G
Y
L
Y
V
T
G
R
I
K
D
L
I
I
I
R
G
R
N
I
W
P
Q
D
I
E
Y
I
-
A
E
Q
E
P
E
---
I
H
S
G
D
A
I
A
F
V
T
A
----------------------------------------
Q
E
K
I
I
L
Q
I
Q
C
R
I
S
-
D
--
E
E
R
R
G
Q
L
I
-
H
A
L
A
A
R
I
Q
S
E
F
G
V
T
A
A
-
I
D
L
L
P
P
H
S
I
P
R
T
S
S
G
K
P
A
R
A
E
A
K
K
R
Y
-----------
55
HHSearch
66.90
21%
-87
- C3 -
4WV3
1
?
A:
[9-519]
--------------------------------
Y
Y
N
A
V
D
I
L
E
R
N
L
P
V
R
A
N
K
T
A
L
F
T
P
D
---------
R
-------
E
M
T
F
R
Q
V
S
N
E
A
N
Q
V
G
N
A
L
K
-
G
L
G
V
R
F
G
E
C
V
G
L
L
T
L
D
S
A
E
W
V
T
S
F
F
G
I
V
K
L
G
A
I
A
V
G
I
-
N
T
L
--
L
-
K
--
P
-
P
----
E
Y
E
Y
I
L
R
D
C
R
A
R
V
L
I
V
H
Q
-
E
F
L
P
L
I
E
S
I
R
G
N
L
P
M
L
E
--
H
I
V
V
I
G
-GYLS
F
N
D
W
---
I
R
P
Q
P
T
-
T
L
E
-
A
A
Q
S
H
R
E
D
I
C
S
L
N
Y
S
S
G
-
T
G
G
P
K
G
I
P
H
A
H
K
D
Y
P
L
T
A
Q
L
W
G
V
N
V
L
-----
G
-
L
R
E
S
D
R
T
F
A
L
A
K
L
F
F
T
F
G
T
G
G
N
L
I
F
---
P
W
Y
V
G
A
-
S
C
V
L
F
P
G
A
A
---
R
V
A
S
N
V
L
S
T
I
S
--
R
----
F
K
P
T
I
F
Y
N
A
P
T
G
Y
A
A
A
L
A
L
K
D
-----
F
S
-
Q
-
H
D
L
S
S
-
L
R
L
C
V
S
-
A
S
-
E
A
L
P
A
A
L
W
Y
A
W
K
E
A
T
G
------
V
D
I
I
D
G
I
G
C
T
E
N
F
H
I
F
I
S
N
R
P
G
----------------------------
D
I
R
--
P
G
S
S
G
K
P
V
E
G
Y
E
L
K
L
V
D
D
E
-
G
--------
K
T
V
P
A
G
E
I
G
N
V
L
L
R
S
E
T
A
A
L
S
Y
W
H
N
F
E
K
S
R
Q
T
F
-------------------
Q
G
E
----
W
L
A
T
G
D
K
Y
F
V
D
A
D
G
Y
Y
W
H
A
G
R
S
D
D
M
L
K
V
G
G
I
W
V
S
P
V
E
V
E
S
T
L
-
I
Q
H
P
A
---
V
Q
E
C
--
A
V
I
G
C
P
D
Q
----------------
S
-------------------
R
L
I
K
P
K
A
F
I
I
L
K
P
E
Q
-
I
P
S
E
A
L
I
R
Q
I
T
-
D
H
C
T
E
K
M
A
A
--
Y
K
R
P
R
W
I
E
F
--
V
T
E
L
P
K
T
A
T
G
K
I
Q
R
F
K
L
R
S
A
A
K
L
A
--------
9
PsiBlast_PDB
65.93
23%
-77
- C3 -
4R0M
1
?
B:
[70-546]
----------------------------------------------------------------------------------------------------
G
H
K
V
I
L
Q
I
A
K
N
Q
D
F
I
P
A
L
W
A
C
F
L
G
G
I
I
P
V
P
L
T
V
A
P
SY
D
L
E
N
S
A
V
K
----
K
L
E
N
V
W
K
I
L
D
N
P
L
I
L
S
D
S
-
E
L
I
T
E
I
E
K
-
L
G
T
Y
S
H
L
E
G
W
Q
V
I
S
V
N
E
-------
L
R
K
A
P
S
K
I
E
Q
-
L
---
P
I
-
L
D
P
Q
D
A
A
L
L
L
F
T
S
G
S
T
G
M
P
K
G
V
I
L
T
H
H
N
I
L
S
M
T
A
G
-
T
V
V
M
------
N
H
F
T
Q
Q
E
V
T
L
N
W
M
P
L
D
H
V
G
A
I
V
F
-
L
G
I
---
M
A
V
D
L
A
-
C
D
Q
I
H
V
P
M
E
L
V
L
R
Q
P
L
Q
W
L
E
L
I
Q
--
K
H
-
Q
V
S
---
I
S
W
-
S
P
N
F
A
F
S
L
I
N
Q
Q
A
E
E
-
L
K
H
V
-
S
-
Y
N
L
S
S
-
M
-
K
F
L
V
-
N
A
G
E
Q
V
S
V
K
T
I
R
L
F
L
E
I
L
E
K
H
Q
L
Q
E
R
A
I
K
P
A
F
G
M
T
E
S
---
C
S
G
I
T
W
S
A
G
L
S
K
N
E
L
T
E
E
----
N
S
F
V
S
L
G
K
P
-
I
P
G
A
T
I
--
R
-------------
I
V
D
Q
E
N
N
----
P
-----
L
P
E
R
E
I
G
R
L
Q
I
Q
G
N
S
V
T
K
G
Y
Y
N
N
N
E
L
N
Q
E
V
F
-------------------
Q
E
G
----
W
F
T
T
G
D
L
G
Y
L
S
-
K
G
E
L
F
I
T
G
R
E
K
Q
E
I
I
I
N
G
V
N
Y
F
A
H
E
L
E
T
T
I
E
E
L
E
G
----
V
K
V
S
Y
T
A
A
F
A
V
F
-----------------------------------
D
Q
S
R
E
T
D
L
L
I
I
T
F
S
P
E
S
E
-
Q
--
F
E
Q
G
I
K
V
V
-
R
K
I
R
S
H
V
T
Q
K
F
G
I
A
P
A
Y
V
I
P
L
E
R
N
L
V
P
K
T
S
I
G
K
V
Q
K
S
K
L
K
K
D
F
E
Q
G
--------