@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2251: (2016-05-09 )
MRWRASSAPSISAPPIATGCCTPAASPPQTCCGAKTPVSRMRPTRCCCPAAPTGEDAVADILHYCSDHGIAVVPFGGGTSVVGGLDPVRNDFRAVISLDMRRFDRLHRIDEVSGEAELEAGVTGPEAERLLGEHGFSLGHFPQSFEFATIGGFAATRSSGQDSAGYGRFNDMILGLRMITPVGVLDLGRVPASAAGPDLRQLAIGSEGVFGVITRVRLRVHRIPESTRYEAWSFPDFATGVAALRTITQTGTGPTVVRLSDEAETGVNLATTEAIGETQITGGCLGITVFEGTQEHTESRHAETRALLAARGGTSLGEGPARAWERGRFAAPYLRDSLLAAGALCETLETATVWSNTPVLKAAVTEALTTSLAASGTPALVMCHVSHVYPTGASLYFTVVAGQRGDPIEQWLAAKKAASDAIMATGGTITHHHAVGSDHRPWMRAEVGDLGVTLLRTIKATLDPAGILNPGKLIP
Atome Classification :
(20 SA)
-----------------------------------------------------------------------------------.........10........20....----....30........40........50........60........70........80..-......90........100.......110.......120-------.......130.......140......---.150...-....160.......170.......180....--..--.190---------.........200.......210.......220....--...230.......240--........-250-.......260-.-.-----------.....-------270---------.-------------.-------....----.------------------.--280-------..--------......290.......300.......310--------------...---...---.-.-320.......330--........340..---------.....350..-...----..360.......370.....--.--.380.......390----......--.---400...-.---..-..410.......420.......430.......440.......-450.......460.......470...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------------------------------------------------------MRWRASSAPSISAPPIATGCCTPAA----SP
P
Q
TCCGAKTPVSRMRPTRCCCPAAPTG
E
D
A
V
A
D
I
L
H
Y
CSDH
G
I
A
V
V
PFGGGTSVVG-GL
D
P
V
R
N
D
F
R
A
V
I
S
L
D
M
R
R
F
D
R
L
H
R
I
D
EVSGE
A
E
LEAGV-------T
G
P
E
A
E
R
L
L
G
EHGFSLGHFPQSF
E
F
A
---
T
IGGFAA-TRSSGQDSAGYGR
F
N
D
M
I
L
G
L
R
M
ITPV
G
V
L
D--LG--RV-----------PASAAGP
D
L
R
Q
LAIGSE
G
V
F
G
V
I
T
R
V
R
L
R
VHRIPES--TRYEAWSF
P
D
F
A
T
G
V
---
A
A
L
R
T
I
T
Q-TGT-G
P
T
V
V
R
LSDE-A-E-----------TGV
N
L
-------
A
T
----------T-------------E-------AIGE----T------------------Q--IT--------G
G
--------
C
L
G
I
T
V
FEG
T
Q
E
H
T
E
S
R
H
A
E
T
R
A
L
LAAR---------------GGT---SLG---E-G-
P
A
R
A
W
ERGRFA
A
---
P
Y
L
R
D
S
L
L
A
A
G
A
L
---------
C
E
T
L
E
T
ATVW-SNT----
P
V
L
K
A
A
V
T
E
A
L
T
T
S
LAASGT--
P
--
A
L
V
M
C
HVSHVYPTG----
A
S
L
Y
F
T
--
V
---V-AGQR-G---
D
P
-
I
E
Q
W
L
A
A
K
KAAS
D
A
I
M
ATGG
T
I
T
H
H
HAVGSDHRP
W
M
R
A
E
V
G
D
-
L
G
V
T
L
L
R
T
I
K
A
TLDPAGILNPGKLIP
42
HHSearch
94.06
31%
-80
- C1 -
4BBY
4
ADAS_CAVPO
A:
[202-658]
--------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
P
D
I
V
L
W
P
T
C
H
D
D
V
V
K
I
V
N
L
A
C
K
Y
N
L
C
I
I
P
I
G
G
G
T
S
V
S
Y
-
G
L
M
C
P
A
D
E
T
R
T
I
I
S
L
D
T
S
Q
M
N
R
I
L
W
V
D
E
N
N
L
T
A
H
V
E
A
G
I
-------
T
G
Q
E
L
E
R
Q
L
K
E
S
G
Y
C
T
G
H
E
P
D
S
L
E
F
S
---
T
V
G
G
W
I
S
-
T
R
A
S
G
M
K
K
N
I
Y
G
N
I
E
D
L
V
V
H
M
K
V
V
T
P
R
G
V
I
E
--
K
S
C-
Q
G
-----------
P
R
M
S
T
G
P
D
I
H
H
F
I
M
G
S
E
G
T
L
G
V
I
T
E
A
T
I
K
I
R
P
T
P
E
Y
--
Q
K
Y
G
S
V
A
F
P
N
F
E
Q
G
V
---
A
C
L
R
E
I
A
K
-
Q
R
C
-
A
P
A
S
I
R
L
M
D
N
Q
Q
-
F
-----------
Q
F
G
H
A
-------
L
K
----------
P
-------------
Q
VSSIFTS---------------------------
G
FD
P
N
--------
Q
L
--------
S
V
A
T
L
L
F
E
G
D
R
E
K
V
L
Q
H
E
K
Q
V
Y
D
I
A
A
K
F
---------------
G
G
L
---
A
A
G
---
E
-
D
-
N
G
Q
R
G
Y
L
L
T
Y
V
I
---
A
Y
M
R
D
L
G
L
E
Y
Y
I
I
---------
G
E
S
F
E
T
S
A
P
W
-
D
R
V
----
V
D
L
C
R
N
V
K
E
R
I
R
R
E
C
K
E
K
G
V
--
Q
FP
P
L
S
T
C
R
V
T
Q
T
Y
D
A
G
----
A
C
I
Y
F
Y
--
F
---
A
-
F
N
Y
R
-
G
IS-
D
P
-
L
A
V
F
E
Q
T
E
A
A
A
R
E
E
I
L
A
N
G
G
S
L
S
H
H
H
G
V
G
K
L
R
K
Q
W
L
K
E
S
I
S
D
-
V
G
F
G
M
L
K
S
V
K
D
Y
V
D
P
T
N
I
F
G
N
R
N
L
L
-
4
PsiBlast_PDB
93.65
30%
-79
- C1 -
5AE1
3
ADAS_CAVPO
A:
[212-658]
------------------------------------------------------------------------------------------------------------------------------------------
P
T
C
H
D
D
V
V
K
I
V
N
L
A
C
K
Y
N
L
C
I
I
P
I
G
G
G
T
S
V
S
Y
-
G
L
M
C
P
A
D
E
T
R
T
I
I
S
L
D
T
S
Q
M
N
R
I
L
W
V
D
E
N
N
L
T
A
H
V
E
A
G
I
-------
T
G
Q
E
L
E
R
Q
L
K
E
S
G
Y
C
T
G
H
E
P
D
S
L
E
F
S
---
T
V
G
G
W
I
S
-
T
R
A
S
G
M
K
K
N
I
Y
G
N
I
E
D
L
V
V
H
M
K
V
V
T
P
R
G
V
I
E
--
K
S
C-
Q
G
-----------
P
R
M
S
T
G
P
D
I
H
H
F
I
M
G
S
E
G
T
L
G
V
I
T
E
A
T
I
K
I
R
P
T
P
E
Y
--
Q
K
Y
G
S
V
A
F
P
N
F
E
Q
G
V
---
A
C
L
R
E
I
A
K
-
Q
R
C
-
A
P
A
S
I
R
L
M
D
N
-
Q
-
Q
F
Q
F
G
H
A
L
KPQV
S
S
I
F
T
-------
S
F
----------
L
-------------
D
-------
G
L
K
K
----
F
------------------
Y
--
I
-----------KGFDPNQ
L
S
V
A
T
L
L
F
E
G
D
R
E
K
V
L
Q
H
E
K
Q
V
Y
D
I
A
A
K
F
---------------
G
G
L
---
A
A
G
---
E
-
D
-
N
G
Q
R
G
Y
L
L
T
Y
V
I
---
A
Y
M
R
D
L
G
L
E
Y
Y
I
I
---------
G
E
S
F
E
T
S
A
P
W
-
D
R
V
----
V
D
L
C
R
N
V
K
E
R
I
R
R
E
C
K
E
K
G
V
QF
P
--
P
L
S
T
C
R
V
T
Q
T
Y
D
A
G
----
A
C
I
Y
F
Y
--
F
---
A
-
F
N
Y
R
-
G
IS-
D
P
-
L
A
V
F
E
Q
T
E
A
A
A
R
E
E
I
L
A
N
G
G
S
L
S
H
H
H
G
V
G
K
L
R
K
Q
W
L
K
E
S
I
S
D
-
V
G
F
G
M
L
K
S
V
K
D
Y
V
D
P
T
N
I
F
G
N
R
N
L
L
-
6
PsiBlast_PDB
93.58
30%
-83
- C1 -
5AE3
4
ADAS_CAVPO
A:
[212-658]
------------------------------------------------------------------------------------------------------------------------------------------
P
T
C
H
D
D
V
V
K
I
V
N
L
A
C
K
Y
N
L
C
I
I
P
I
G
G
G
T
S
V
S
Y
-
G
L
M
C
P
A
D
E
T
R
T
I
I
S
L
D
T
S
Q
M
N
R
I
L
W
V
D
E
N
N
L
T
A
H
V
E
A
G
I
-------
T
G
Q
E
L
E
R
Q
L
K
E
S
G
Y
C
T
G
H
E
P
D
S
L
E
F
S
---
T
V
G
G
W
I
S
-
T
R
A
S
G
M
K
K
N
I
Y
G
N
I
E
D
L
V
V
H
M
K
V
V
T
P
R
G
V
I
E
--
K
S
C-
Q
G
-----------
P
R
M
S
T
G
P
D
I
H
H
F
I
M
G
S
E
G
T
L
G
V
I
T
E
A
T
I
K
I
R
P
T
P
E
Y
--
Q
K
Y
G
S
V
A
F
P
N
F
E
Q
G
V
---
A
C
L
R
E
I
A
K
-
Q
R
C
-
A
P
A
S
I
R
L
M
D
N
-
Q
-
Q
F
Q
F
G
H
A
L--------------------------------------------------------------------------------------------GFDPNQ
L
-
S
V
A
T
L
L
F
E
G
D
R
E
K
V
L
Q
H
E
K
Q
V
Y
D
I
A
A
K
F
---------------
G
G
L
---
A
A
G
---
E
-
D
-
N
G
Q
R
G
Y
L
L
T
Y
V
I
---
A
Y
M
R
D
L
G
L
E
Y
-
I
I
---------
G
E
S
F
E
T
S
A
P
W
-
D
R
V
----
V
D
L
C
R
N
V
K
E
R
I
R
R
E
C
K
E
K
G
V
QF
P
--
P
L
S
T
C
R
V
T
Q
T
Y
D
A
G
----
A
C
I
Y
F
Y
--
F
---
A
-
F
N
Y
R
-
G
IS-
D
P
-
L
A
V
F
E
Q
T
E
A
A
A
R
E
E
I
L
A
N
G
G
S
L
S
H
H
H
G
V
G
K
L
R
K
Q
W
L
K
E
S
I
S
D
-
V
G
F
G
M
L
K
S
V
K
D
Y
V
D
P
T
N
I
F
G
N
R
N
L
L
-
5
PsiBlast_PDB
93.26
30%
-81
- C1 -
5AE2
3
ADAS_CAVPO
A:
[212-658]
------------------------------------------------------------------------------------------------------------------------------------------
P
T
C
H
D
D
V
V
K
I
V
N
L
A
C
K
Y
N
L
C
I
I
P
I
G
G
G
T
S
V
S
Y
-
G
L
M
C
P
A
D
E
T
R
T
I
I
S
L
D
T
S
Q
M
N
R
I
L
W
V
D
E
N
N
L
T
A
H
V
E
A
G
I
-------
T
G
Q
E
L
E
R
Q
L
K
E
S
G
Y
C
T
G
H
E
P
D
S
L
E
F
S
---
T
V
G
G
W
I
S
-
T
R
A
S
G
M
K
K
N
I
Y
G
N
I
E
D
L
V
V
H
M
K
V
V
T
P
R
G
V
I
E
--
K
S
C-
Q
G
-----------
P
R
M
S
T
G
P
D
I
H
H
F
I
M
G
S
E
G
T
L
G
V
I
T
E
A
T
I
K
I
R
P
T
P
E
Y
--
Q
K
Y
G
S
V
A
F
P
N
F
E
Q
G
V
---
A
C
L
R
E
I
A
K
-
Q
R
C
-
A
P
A
S
I
R
L
M
D
N
-
Q
-
Q
F
Q
F
G
H
A
L
KPQV
S
S
I
F
T
-------
S
F
----------
L
-------------
D
-------
G
L
K
K
--------------------------------------FDPNQ
L
--
S
V
A
T
L
L
F
E
G
D
R
E
K
V
L
Q
H
E
K
Q
V
Y
D
I
A
A
K
F
---------------
G
G
L
---
A
A
G
---
E
-
D
-
N
G
Q
R
G
Y
L
L
T
Y
V
I
---
A
Y
M
R
D
L
G
L
E
Y
Y
I
I
---------
G
E
S
F
E
T
S
A
P
W
-
D
R
V
----
V
D
L
C
R
N
V
K
E
R
I
R
R
E
C
K
E
K
G
V
QF
P
--
P
L
S
T
C
R
V
T
Q
T
Y
D
A
G
----
A
C
I
Y
F
Y
--
F
---
A
-
F
N
Y
R
-
G
IS-
D
P
-
L
A
V
F
E
Q
T
E
A
A
A
R
E
E
I
L
A
N
G
G
S
L
S
H
H
H
G
V
G
K
L
R
K
Q
W
L
K
E
S
I
S
D
-
V
G
F
G
M
L
K
S
V
K
D
Y
V
D
P
T
N
I
F
G
N
R
N
L
L
-
3
PsiBlast_PDB
92.93
30%
-81
- C1 -
4BC9
4
ADAS_CAVPO
A:
[212-658]
------------------------------------------------------------------------------------------------------------------------------------------
P
T
C
H
D
D
V
V
K
I
V
N
L
A
C
K
Y
N
L
C
I
I
P
I
G
G
G
T
S
V
S
Y
-
G
L
M
C
P
A
D
E
T
R
T
I
I
S
L
D
T
S
Q
M
N
R
I
L
W
V
D
E
N
N
L
T
A
H
V
E
A
G
I
-------
T
G
Q
E
L
E
R
Q
L
K
E
S
G
Y
C
T
G
H
E
P
D
S
L
E
F
S
---
T
V
G
G
W
I
S
-
T
R
A
S
G
M
K
K
N
I
Y
G
N
I
E
D
L
V
V
H
M
K
V
V
T
P
R
G
V
I
E
--
K
S
C-
Q
G
-----------
P
R
M
S
T
G
P
D
I
H
H
F
I
M
G
S
E
G
T
L
G
V
I
T
E
A
T
I
K
I
R
P
T
P
E
Y
--
Q
K
Y
G
S
V
A
F
P
N
F
E
Q
G
V
---
A
C
L
R
E
I
A
K
-
Q
R
C
-
A
P
A
S
I
R
L
M
D
N
-
Q
-
Q
F
Q
F
G
H
A
L
KP
Q
V
S
S
I
F
T
-------
S
---------------------------------------------------------------------------GFDPNQ
L
-
S
V
A
T
L
L
F
E
G
D
R
E
K
V
L
Q
H
E
K
Q
V
Y
D
I
A
A
K
F
---------------
G
G
L
---
A
A
G
---
E
-
D
-
N
G
Q
R
G
Y
L
L
T
Y
V
I
---
A
Y
M
R
D
L
G
L
E
Y
Y
I
I
---------
G
E
S
F
E
T
S
A
P
W
-
D
R
V
----
V
D
L
C
R
N
V
K
E
R
I
R
R
E
C
K
E
K
G
V
QF
P
--
P
L
S
T
C
R
V
T
Q
T
Y
D
A
G
----
A
C
I
Y
F
Y
--
F
---
A
-
F
N
Y
R
-
G
IS-
D
P
-
L
A
V
F
E
Q
T
E
A
A
A
R
E
E
I
L
A
N
G
G
S
L
S
H
H
H
G
V
G
K
L
R
K
Q
W
L
K
E
S
I
S
D
-
V
G
F
G
M
L
K
S
V
K
D
Y
V
D
P
T
N
I
F
G
N
R
N
L
L
-
8
PsiBlast_PDB
92.59
30%
-82
- C1 -
4BCA
5
ADAS_CAVPO
A:
[212-658]
------------------------------------------------------------------------------------------------------------------------------------------
P
T
C
H
D
D
V
V
K
I
V
N
L
A
C
K
Y
N
L
C
I
I
P
I
G
G
G
T
S
V
S
Y
-
G
L
M
C
P
A
D
E
T
R
T
I
I
S
L
D
T
S
Q
M
N
R
I
L
W
V
D
E
N
N
L
T
A
H
V
E
A
G
I
-------
T
G
Q
E
L
E
R
Q
L
K
E
S
G
Y
C
T
G
H
E
P
D
S
L
E
F
S
---
T
V
G
G
W
I
S
-
T
R
A
S
G
M
K
K
N
I
Y
G
N
I
E
D
L
V
V
H
M
K
V
V
T
P
R
G
V
I
E
--
K
S
C-
Q
G
-----------
P
R
M
S
T
G
P
D
I
H
H
F
I
M
G
S
E
G
T
L
G
V
I
T
E
A
T
I
K
I
R
P
T
P
E
Y
--
Q
K
Y
G
S
V
A
F
P
N
F
E
Q
G
V
---
A
C
L
R
E
I
A
K
-
Q
R
C
-
A
P
A
S
I
R
L
M
D
N
-
Q
-
Q
F
Q
F
G
H
A
L
KP
Q
V
S
S
I
F
T
-------
S
---------------------------------------------------------------------------GFDPNQ
L
-
S
V
A
T
L
L
F
E
G
D
R
E
K
V
L
Q
H
E
K
Q
V
Y
D
I
A
A
K
F
---------------
G
G
L
---
A
A
G
---
E
-
D
-
N
G
Q
R
G
Y
L
L
T
Y
V
I
---
A
Y
M
R
D
L
G
L
E
Y
Y
I
I
---------
G
E
S
F
E
T
S
A
P
W
-
D
R
V
----
V
D
L
C
R
N
V
K
E
R
I
R
R
E
C
K
E
K
G
V
QF
P
--
P
L
S
T
C
R
V
T
Q
T
Y
D
A
G
----
A
C
I
F
F
Y
--
F
---
A
-
F
N
Y
R
-
G
IS-
D
P
-
L
A
V
F
E
Q
T
E
A
A
A
R
E
E
I
L
A
N
G
G
S
L
S
H
H
H
G
V
G
K
L
R
K
Q
W
L
K
E
S
I
S
D
-
V
G
F
G
M
L
K
S
V
K
D
Y
V
D
P
T
N
I
F
G
N
R
N
L
L
-
7
PsiBlast_PDB
92.57
30%
-80
- C1 -
5ADZ
2
ADAS_CAVPO
A:
[212-658]
------------------------------------------------------------------------------------------------------------------------------------------
P
T
C
H
D
D
V
V
K
I
V
N
L
A
C
K
Y
N
L
C
I
I
P
I
G
G
G
T
S
V
S
Y
-
G
L
M
C
P
A
D
E
T
R
T
I
I
S
L
D
T
S
Q
M
N
R
I
L
W
V
D
E
N
N
L
T
A
H
V
E
A
G
I
-------
T
G
Q
E
L
E
R
Q
L
K
E
S
G
Y
C
T
G
H
E
P
D
S
L
E
F
S
---
T
V
G
G
W
I
S
-
T
R
A
S
G
M
K
K
N
I
Y
G
N
I
E
D
L
V
V
H
M
K
V
V
T
P
R
G
V
I
E
--
K
S
C-
Q
G
-----------
P
R
M
S
T
G
P
D
I
H
H
F
I
M
G
S
E
G
T
L
G
V
I
T
E
A
T
I
K
I
R
P
T
P
E
Y
--
Q
K
Y
G
S
V
A
F
P
N
F
E
Q
G
V
---
A
C
L
R
E
I
A
K
-
Q
R
C
-
A
P
A
S
I
R
L
M
D
N
-
Q
-
Q
F
Q
F
G
H
A
L
KPQV
S
S
I
F
T
-------
S
F
----------
L
-------------
D
-------
G
L
K
K
----
F
------------------
Y
--
I
T
--------
K
F
KGFDPNQ
L
S
V
A
T
L
L
F
E
G
D
R
E
K
V
L
Q
H
E
K
Q
V
Y
D
I
A
A
K
F
---------------
G
G
L
---
A
A
G
---
E
-
D
-
N
G
Q
R
G
Y
L
L
T
Y
V
I
---
A
Y
M
R
D
L
G
L
E
Y
Y
I
I
---------
G
E
S
F
E
T
S
A
P
W
-
D
R
V
----
V
D
L
C
R
N
V
K
E
R
I
R
R
E
C
K
E
K
G
V
QF
P
--
P
L
S
T
C
R
V
T
Q
T
Y
D
A
G
----
A
C
I
Y
F
Y
--
F
---
A
-
F
N
Y
R
-
G
IS-
D
P
-
L
A
V
F
E
Q
T
E
A
A
A
R
E
E
I
L
A
N
G
G
S
L
S
H
H
H
G
V
G
K
L
R
K
Q
W
L
K
E
S
I
S
D
-
V
G
F
G
M
L
K
S
V
K
D
Y
V
D
P
T
N
I
F
G
N
R
N
L
L
-
2
PsiBlast_PDB
92.39
30%
-81
- C1 -
4BBY
4
ADAS_CAVPO
A:
[212-658]
------------------------------------------------------------------------------------------------------------------------------------------
P
T
C
H
D
D
V
V
K
I
V
N
L
A
C
K
Y
N
L
C
I
I
P
I
G
G
G
T
S
V
S
Y
-
G
L
M
C
P
A
D
E
T
R
T
I
I
S
L
D
T
S
Q
M
N
R
I
L
W
V
D
E
N
N
L
T
A
H
V
E
A
G
I
-------
T
G
Q
E
L
E
R
Q
L
K
E
S
G
Y
C
T
G
H
E
P
D
S
L
E
F
S
---
T
V
G
G
W
I
S
-
T
R
A
S
G
M
K
K
N
I
Y
G
N
I
E
D
L
V
V
H
M
K
V
V
T
P
R
G
V
I
E
--
K
S
C-
Q
G
-----------
P
R
M
S
T
G
P
D
I
H
H
F
I
M
G
S
E
G
T
L
G
V
I
T
E
A
T
I
K
I
R
P
T
P
E
Y
--
Q
K
Y
G
S
V
A
F
P
N
F
E
Q
G
V
---
A
C
L
R
E
I
A
K
-
Q
R
C
-
A
P
A
S
I
R
L
M
D
N
-
Q
-
Q
F
Q
F
G
H
A
L
KPQV
S
S
I
F
T
-------
S
---------------------------------------------------------------------------GFDPNQ
L
-
S
V
A
T
L
L
F
E
G
D
R
E
K
V
L
Q
H
E
K
Q
V
Y
D
I
A
A
K
F
---------------
G
G
L
---
A
A
G
---
E
-
D
-
N
G
Q
R
G
Y
L
L
T
Y
V
I
---
A
Y
M
R
D
L
G
L
E
Y
Y
I
I
---------
G
E
S
F
E
T
S
A
P
W
-
D
R
V
----
V
D
L
C
R
N
V
K
E
R
I
R
R
E
C
K
E
K
G
V
QF
P
--
P
L
S
T
C
R
V
T
Q
T
Y
D
A
G
----
A
C
I
Y
F
Y
--
F
---
A
-
F
N
Y
R
-
G
IS-
D
P
-
L
A
V
F
E
Q
T
E
A
A
A
R
E
E
I
L
A
N
G
G
S
L
S
H
H
H
G
V
G
K
L
R
K
Q
W
L
K
E
S
I
S
D
-
V
G
F
G
M
L
K
S
V
K
D
Y
V
D
P
T
N
I
F
G
N
R
N
L
L
-
9
PsiBlast_PDB
92.14
30%
-80
- C1 -
4BC7
2
ADAS_CAVPO
A:
[212-658]
------------------------------------------------------------------------------------------------------------------------------------------
P
T
C
H
D
D
V
V
K
I
V
N
L
A
C
K
Y
N
L
C
I
I
P
I
G
G
G
T
S
V
S
Y
-
G
L
M
C
P
A
D
E
T
R
T
I
I
S
L
D
T
S
Q
M
N
R
I
L
W
V
D
E
N
N
L
T
A
H
V
E
A
G
I
-------
T
G
Q
E
L
E
R
Q
L
K
E
S
G
Y
C
T
G
H
E
P
D
S
L
E
F
S
---
T
V
G
G
W
I
S
-
T
R
A
S
G
M
K
K
N
I
Y
G
N
I
E
D
L
V
V
H
M
K
V
V
T
P
R
G
V
I
E
--
K
S
C-
Q
G
-----------
P
R
M
S
T
G
P
D
I
H
H
F
I
M
G
S
E
G
T
L
G
V
I
T
E
A
T
I
K
I
R
P
T
P
E
Y
--
Q
K
Y
G
S
V
A
F
P
N
F
E
Q
G
V
---
A
C
L
R
E
I
A
K
-
Q
R
C
-
A
P
A
S
I
H
L
M
D
N
-
Q
-
Q
F
Q
F
G
H
A
L
KP
Q
V
S
S
I
F
T
-------
S
---------------------------------------------------------------------------GFDPNQ
L
-
S
V
A
T
L
L
F
E
G
D
R
E
K
V
L
Q
H
E
K
Q
V
Y
D
I
A
A
K
F
---------------
G
G
L
---
A
A
G
---
E
-
D
-
N
G
Q
R
G
Y
L
L
T
Y
V
I
---
A
Y
M
R
D
L
G
L
E
Y
Y
I
I
---------
G
E
S
F
E
T
S
A
P
W
-
D
R
V
----
V
D
L
C
R
N
V
K
E
R
I
R
R
E
C
K
E
K
G
V
QF
P
--
P
L
S
T
C
R
V
T
Q
T
Y
D
A
G
----
A
C
I
Y
F
Y
--
F
---
A
-
F
N
Y
R
-
G
IS-
D
P
-
L
A
V
F
E
Q
T
E
A
A
A
R
E
E
I
L
A
N
G
G
S
L
S
H
H
H
G
V
G
K
L
R
K
Q
W
L
K
E
S
I
S
D
-
V
G
F
G
M
L
K
S
V
K
D
Y
V
D
P
T
N
I
F
G
N
R
N
L
L
-
64
Fugue
91.79
30%
-83
- C1 -
2UUU
2
ADAS_DICDI
A:
[3-583]
MGSPKEHID
L
Y
Q
Q
I
KWNGWGDTR
K
F
L
H
Q
L
K
PSG
T
I
A
M
T
T
PEVSSVPLPS
L
R
G
F
I
K
K
E
L
TK
P
F
V
L
D
E
T
P
A
L
QIEN
I
H
V
D
P
PKQY
P
E
F
V
R
E
L
K
A
F
F
L
P
D
Q
L
K
D
D
K
L
A
R
I
T
H
T
F
G
K
S
L
R
D
L
I
R
V
R
I
G
Q
V
K
N
A
P
D
L
I
V
L
P
---
H
S
H
E
E
V
E
R
L
V
Q
L
A
H
K
Y
N
V
V
I
I
P
M
G
G
G
S
N
I
V
G
-
A
I
E
P
V
S
N
E
-
R
F
T
V
S
I
D
M
R
R
M
N
K
V
L
W
V
D
R
R
E
M
T
A
C
I
Q
V
G
I
-------
M
G
P
E
L
E
K
Q
L
H
K
Q
G
V
S
L
G
H
D
P
D
S
F
E
F
S
---
T
L
G
G
W
L
A
-
T
C
S
S
G
H
Q
S
D
K
Y
G
D
I
E
D
M
A
V
S
F
R
T
V
T
P
T
G
T
L
E
----------------------
L
R
G
I
N
Y
K
H
I
I
L
G
S
E
G
T
L
G
I
I
T
E
A
V
M
K
V
H
A
V
P
Q
A
--
V
E
Y
Y
G
F
L
F
P
T
F
A
H
A
V
---
S
A
L
Q
Q
I
R
S
-
S
E
V
-
I
P
T
M
I
R
V
Y
D
P
-
E
-
E
-----------
T
Q
L
S
F
-------
A
W
KPSKGAVSEF
T
-------------
S
-------
A
M
V
K
----
K
------------------
Y
--
L
H
Y
I
R
S
F
DFK
N
V
--------
C
L
S
I
I
G
F
E
G
P
K
K
V
V
D
F
H
R
T
S
V
F
D
I
L
S
K
N
---------------
A
A
F
---
G
L
G
---
S
-
A
-
P
G
K
T
W
A
E
K
R
Y
D
L
---
P
Y
I
R
D
F
L
L
D
H
N
M
W
---------
V
D
V
A
E
T
T
V
S
Y
-
A
N
L
----
Q
T
L
W
K
D
A
K
Q
T
F
V
K
H
F
K
D
Q
G
I
--
P
--
A
W
I
C
A
H
I
S
H
T
Y
T
N
G
----
V
C
L
Y
F
I
--
F
---
A
-
S
K
Q
N
-
E
N--
K
D
-
M
A
Q
Y
I
E
A
K
K
L
M
T
D
I
I
F
K
Y
G
G
S
L
S
R
G
-------------------
W
I
N
V
Y
R
S
L
K
E
T
I
D
P
K
D
I
C
N
P
R
K
L
--
21
PsiBlast_CBE
89.49
33%
-88
- C1 -
2UUV
2
ADAS_DICDI
D:
[144-581]
------------------------------------------------------------------------------------------------------------------------------------------
P
H
S
H
E
E
V
E
R
L
V
Q
L
A
H
K
Y
N
V
V
I
I
P
M
G
G
G
S
N
I
V
G
-
A
I
E
P
V
S
N
E
-
R
F
T
V
S
I
D
M
R
R
M
N
K
V
L
W
V
D
R
R
E
M
T
A
C
I
Q
V
G
I
-------
M
G
P
E
L
E
K
Q
L
H
K
Q
G
V
S
L
G
H
D
P
D
S
F
E
F
S
---
T
L
G
G
W
L
A
-
T
C
S
S
G
H
Q
S
D
K
Y
G
D
I
E
D
M
A
V
S
F
R
T
V
T
P
T
G
T
L
E
--
L
R
--------------------
G
I
N
Y
K
H
I
I
L
G
S
E
G
T
L
G
I
I
T
E
A
V
M
K
V
H
A
V
P
Q
A
--
V
E
Y
Y
G
F
L
F
P
T
F
A
H
A
V
---
S
A
L
Q
Q
I
R
S
-
S
E
V
-
I
P
T
M
I
R
V
Y
D
P
-
E
-
E
-----------
T
Q
L
S
F
-------
A
W
----------
K
-------------
P
-------
S
K
G
A
----
V
SEFT
S
A
M
V
K
K
Y
L
H
Y
I
R
S
F
D
--
F
K
--------
N
V
--------
C
L
S
I
I
G
F
E
G
P
K
K
V
V
D
F
H
R
T
S
V
F
D
I
L
S
K
N
---------------
A
A
F
---
G
L
G
---
S
-
A
-
P
G
K
T
W
A
E
K
R
Y
D
L
---
P
Y
I
R
D
F
L
L
D
H
N
M
W
---------
V
D
V
A
E
T
T
V
S
Y
-
A
N
L
----
Q
T
L
W
K
D
A
K
Q
T
F
V
K
H
F
K
D
Q
G
I
--
P
--
A
W
I
C
A
H
I
S
H
T
Y
T
N
G
----
V
C
L
Y
F
I
--
F
---
A
-
S
K
Q
N
--------------
A
K
K
L
M
T
D
I
I
F
K
Y
G
G
S
----------------------
G
W
I
N
V
Y
R
S
L
K
E
T
I
D
P
K
D
I
C
N
P
R
----
1
PsiBlast_PDB
87.30
33%
-86
- C1 -
2UUU
2
ADAS_DICDI
A:
[144-583]
------------------------------------------------------------------------------------------------------------------------------------------
P
H
S
H
E
E
V
E
R
L
V
Q
L
A
H
K
Y
N
V
V
I
I
P
M
G
G
G
S
N
I
V
G
-
A
I
E
P
V
S
N
E
-
R
F
T
V
S
I
D
M
R
R
M
N
K
V
L
W
V
D
R
R
E
M
T
A
C
I
Q
V
G
I
-------
M
G
P
E
L
E
K
Q
L
H
K
Q
G
V
S
L
G
H
D
P
D
S
F
E
F
S
---
T
L
G
G
W
L
A
-
T
C
S
S
G
H
Q
S
D
K
Y
G
D
I
E
D
M
A
V
S
F
R
T
V
T
P
T
G
T
L
E
--
L
R
--------------------
G
I
N
Y
K
H
I
I
L
G
S
E
G
T
L
G
I
I
T
E
A
V
M
K
V
H
A
V
P
Q
A
--
V
E
Y
Y
G
F
L
F
P
T
F
A
H
A
V
---
S
A
L
Q
Q
I
R
S
-
S
E
V
-
I
P
T
M
I
R
V
Y
D
P
-
E
-
E
-----------
T
Q
L
S
F
-------
A
W
----------
K
-------------
P
-------
S
K
G
A
----
V
SEF
T
S
A
M
V
K
K
Y
L
H
Y
I
R
S
F
D
--
F
K
--------
N
V
--------
C
L
S
I
I
G
F
E
G
P
K
K
V
V
D
F
H
R
T
S
V
F
D
I
L
S
K
N
---------------
A
A
F
---
G
L
G
---
S
-
A
-
P
G
K
T
W
A
E
K
R
Y
D
L
---
P
Y
I
R
D
F
L
L
D
H
N
M
W
---------
V
D
V
A
E
T
T
V
S
Y
-
A
N
L
----
Q
T
L
W
K
D
A
K
Q
T
F
V
K
H
F
K
D
Q
G
I
--
P
--
A
W
I
C
A
H
I
S
H
T
Y
T
N
G
----
V
C
L
Y
F
I
--
F
---
A
-
S
K
Q
N
-
E
---
N
K
D
M
A
Q
Y
I
E
A
K
K
L
M
T
D
I
I
F
K
Y
G
G
S
L
S
------------------
R
-
G
W
I
N
V
Y
R
S
L
K
E
T
I
D
P
K
D
I
C
N
P
R
K
L
--
43
HHSearch
87.27
32%
-84
- C1 -
2UUU
2
ADAS_DICDI
A:
[135-583]
---------------------------------------------------------------------------------------------------------------------------------
K
N
A
P
D
L
I
V
L
P
H
S
H
E
E
V
E
R
L
V
Q
L
A
H
K
Y
N
V
V
I
I
P
M
G
G
G
S
N
I
V
G
-
A
I
E
P
V
S
N
-
E
R
F
T
V
S
I
D
M
R
R
M
N
K
V
L
W
V
D
R
R
E
M
T
A
C
I
Q
V
G
I
-------
M
G
P
E
L
E
K
Q
L
H
K
Q
G
V
S
L
G
H
D
P
D
S
F
E
F
S
---
T
L
G
G
W
L
A
-
T
C
S
S
G
H
Q
S
D
K
Y
G
D
I
E
D
M
A
V
S
F
R
T
V
T
P
T
G
T
L
E
--
L
R
--------------------
G
I
N
Y
K
H
I
I
L
G
S
E
G
T
L
G
I
I
T
E
A
V
M
K
V
H
A
V
P
Q
A
--
V
E
Y
Y
G
F
L
F
P
T
F
A
H
A
V
---
S
A
L
Q
Q
I
R
S
-
S
E
V
-
I
P
T
M
I
R
V
Y
D
P
E
E
-
T
-----------
Q
L
S
F
A
-------
W
K
----------
P
SKGAVSEF
T
S
A
M
V
K
-------
K
Y
L
H
----
Y
I
R
S
F
--------------
D
--
F
K
--------
N
V
--------
C
L
S
I
I
G
F
E
G
P
K
K
V
V
D
F
H
R
T
S
V
F
D
I
L
S
K
N
---------------
A
A
F
---
G
L
G
---
S
-
A
-
P
G
K
T
W
A
E
K
R
Y
D
L
---
P
Y
I
R
D
F
L
L
D
H
N
M
W
---------
V
D
V
A
E
T
T
V
S
Y
-
A
N
L
----
Q
T
L
W
K
D
A
K
Q
T
F
V
K
H
F
K
D
Q
G
I
--
P
--
A
W
I
C
A
H
I
S
H
T
Y
T
N
G
-----
V
C
L
Y
F
--
I
---
F
A
S
K
Q
N
E
N
---
K
D
-
M
A
Q
Y
I
E
A
K
K
L
M
T
D
I
I
F
K
Y
G
G
S
L
S
------------------
R
-
G
W
I
N
V
Y
R
S
L
K
E
T
I
D
P
K
D
I
C
N
P
R
K
L
--
25
PsiBlast_CBE
87.17
33%
-88
- C1 -
2UUU
2
ADAS_DICDI
B:
[144-583]
------------------------------------------------------------------------------------------------------------------------------------------
P
H
S
H
E
E
V
E
R
L
V
Q
L
A
H
K
Y
N
V
V
I
I
P
M
G
G
G
S
N
I
V
G
-
A
I
E
P
V
S
N
E
-
R
F
T
V
S
I
D
M
R
R
M
N
K
V
L
W
V
D
R
R
E
M
T
A
C
I
Q
V
G
I
-------
M
G
P
E
L
E
K
Q
L
H
K
Q
G
V
S
L
G
H
D
P
D
S
F
E
F
S
---
T
L
G
G
W
L
A
-
T
C
S
S
G
H
Q
S
D
K
Y
G
D
I
E
D
M
A
V
S
F
R
T
V
T
P
T
G
T
L
E
--
L
R
--
N
---------------
G
A
G
I
N
Y
K
H
I
I
L
G
S
E
G
T
L
G
I
I
T
E
A
V
M
K
V
H
A
V
P
Q
A
--
V
E
Y
Y
G
F
L
F
P
T
F
A
H
A
V
---
S
A
L
Q
Q
I
R
S
-
S
E
V
-
I
P
T
M
I
R
V
Y
D
P
-
E
-
E
-----------
T
Q
L
S
F
-------
A
W
----------
K
-------------
P
----------------S
E
F
T
S
A
M
V
K
K
Y
L
H
Y
I
R
SF
D
--
F
K
--------
N
V
--------
C
L
S
I
I
G
F
E
G
P
K
K
V
V
D
F
H
R
T
S
V
F
D
I
L
S
K
N
---------------
A
A
F
---
G
L
G
---
S
-
A
-
P
G
K
T
W
A
E
K
R
Y
D
L
---
P
Y
I
R
D
F
L
L
D
H
N
M
W
---------
V
D
V
A
E
T
T
V
S
Y
-
A
N
L
----
Q
T
L
W
K
D
A
K
Q
T
F
V
K
H
F
K
D
Q
G
I
--
P
--
A
W
I
C
A
H
I
S
H
T
Y
T
N
G
----
V
C
L
Y
F
I
--
F
---
A
-
S
K
Q
N
-
E
-----D
M
A
Q
Y
I
E
A
K
K
L
M
T
D
I
I
F
K
Y
G
G
S
L
S
-----------------
T
R
-
G
W
I
N
V
Y
R
S
L
K
E
T
I
D
P
K
D
I
C
N
P
R
K
L
--
23
PsiBlast_CBE
86.96
33%
-86
- C1 -
2UUU
2
ADAS_DICDI
D:
[144-582]
------------------------------------------------------------------------------------------------------------------------------------------
P
H
S
H
E
E
V
E
R
L
V
Q
L
A
H
K
Y
N
V
V
I
I
P
M
G
G
G
S
N
I
V
G
-
A
I
E
P
V
S
N
E
-
R
F
T
V
S
I
D
M
R
R
M
N
K
V
L
W
V
D
R
R
E
M
T
A
C
I
Q
V
G
I
-------
M
G
P
E
L
E
K
Q
L
H
K
Q
G
V
S
L
G
H
D
P
D
S
F
E
F
S
---
T
L
G
G
W
L
A
-
T
C
S
S
G
H
Q
S
D
K
Y
G
D
I
E
D
M
A
V
S
F
R
T
V
T
P
T
G
T
L
E
--
L
R
-------------------
A
G
I
N
Y
K
H
I
I
L
G
S
E
G
T
L
G
I
I
T
E
A
V
M
K
V
H
A
V
P
Q
A
--
V
E
Y
Y
G
F
L
F
P
T
F
A
H
A
V
---
S
A
L
Q
Q
I
R
S
-
S
E
V
-
I
P
T
M
I
R
V
Y
D
P
-
E
-
E
-----------
T
Q
L
S
F
-------
A
W
----------
K
-------------
P
-------
S
--------S
E
F
T
S
A
M
V
K
K
Y
L
H
Y
I
R
S
F
D
--
F
K
--------
N
V
--------
C
L
S
I
I
G
F
E
G
P
K
K
V
V
D
F
H
R
T
S
V
F
D
I
L
S
K
N
---------------
A
A
F
---
G
L
G
---
S
-
A
-
P
G
K
T
W
A
E
K
R
Y
D
L
---
P
Y
I
R
D
F
L
L
D
H
N
M
W
---------
V
D
V
A
E
T
T
V
S
Y
-
A
N
L
----
Q
T
L
W
K
D
A
K
Q
T
F
V
K
H
F
K
D
Q
G
I
--
P
--
A
W
I
C
A
H
I
S
H
T
Y
T
N
G
----
V
C
L
Y
F
I
--
F
---
A
-
S
K
Q
N
---------
A
Q
Y
I
E
A
K
K
L
M
T
D
I
I
F
K
Y
G
G
S
L
---------------------
G
W
I
N
V
Y
R
S
L
K
E
T
I
D
P
K
D
I
C
N
P
R
K
---
24
PsiBlast_CBE
86.82
33%
-88
* C1 *
2UUU
2
ADAS_DICDI
C:
[144-582]
------------------------------------------------------------------------------------------------------------------------------------------
P
H
S
H
E
E
V
E
R
L
V
Q
L
A
H
K
Y
N
V
V
I
I
P
M
G
G
G
S
N
I
V
G
-
A
I
E
P
V
S
N
E
-
R
F
T
V
S
I
D
M
R
R
M
N
K
V
L
W
V
D
R
R
E
M
T
A
C
I
Q
V
G
I
-------
M
G
P
E
L
E
K
Q
L
H
K
Q
G
V
S
L
G
H
D
P
D
S
F
E
F
S
---
T
L
G
G
W
L
A
-
T
C
S
S
G
H
Q
S
D
K
Y
G
D
I
E
D
M
A
V
S
F
R
T
V
T
P
T
G
T
L
E
--
L
R
--
N
---------------
G
A
G
I
N
Y
K
H
I
I
L
G
S
E
G
T
L
G
I
I
T
E
A
V
M
K
V
H
A
V
P
Q
A
--
V
E
Y
Y
G
F
L
F
P
T
F
A
H
A
V
---
S
A
L
Q
Q
I
R
S
-
S
E
V
-
I
P
T
M
I
R
V
Y
D
P
-
E
-
E
-----------
T
Q
L
S
F
-------
A
W
----------
K
-------------
P
----------------SE
F
T
S
A
M
V
K
K
Y
L
H
Y
I
RSF
D
--
F
K
--------
N
V
--------
C
L
S
I
I
G
F
E
G
P
K
K
V
V
D
F
H
R
T
S
V
F
D
I
L
S
K
N
---------------
A
A
F
---
G
L
G
---
S
-
A
-
P
G
K
T
W
A
E
K
R
Y
D
L
---
P
Y
I
R
D
F
L
L
D
H
N
M
W
---------
V
D
V
A
E
T
T
V
S
Y
-
A
N
L
----
Q
T
L
W
K
D
A
K
Q
T
F
V
K
H
F
K
D
Q
G
I
--
P
--
A
W
I
C
A
H
I
S
H
T
Y
T
N
G
----
V
C
L
Y
F
I
--
F
---
A
-
S
K
Q
N
-
E
---------
Y
I
E
A
K
K
L
M
T
D
I
I
F
K
Y
G
G
S
L
S
------------------
R
-
G
W
I
N
V
Y
R
S
L
K
E
T
I
D
P
K
D
I
C
N
P
R
K
---
22
PsiBlast_CBE
77.46
33%
-88
- C1 -
2UUV
1
ADAS_DICDI
C:
[144-581]
------------------------------------------------------------------------------------------------------------------------------------------
P
H
S
H
E
E
V
E
R
L
V
Q
L
A
H
K
Y
N
V
V
I
I
P
M
G
G
G
S
N
I
V
G
-
A
I
E
P
V
--
E
-
R
F
T
V
S
I
D
M
R
R
M
N
K
V
L
W
V
D
R
R
E
M
T
A
C
I
Q
V
G
I
-------
M
G
P
E
L
E
K
Q
L
H
K
Q
G
V
S
L
G
H
D
P
D
S
F
E
F
S
---
T
L
G
G
W
L
A
-
T
C
S
S
G
H
Q
S
D
K
Y
G
D
I
E
D
M
A
V
S
F
R
T
V
T
P
T
G
T
L
E
--
L
R
-------------------
A
G
I
N
Y
K
H
I
I
L
G
S
E
G
T
L
G
I
I
T
E
A
V
M
K
V
H
A
V
P
Q
A
--
V
E
Y
Y
G
F
L
F
P
T
F
A
H
A
V
---
S
A
L
Q
Q
I
R
S
-
S
E
V
-
I
P
T
M
I
R
V
Y
D
P
-
E
-
E
-----------
T
Q
L
S
F
-------
A
W
----------
K
-------------
P
----------------M
V
K
K
Y
L
H
Y
I
RSF------
D
--
F
K
--------
N
V
--------
C
L
S
I
I
G
F
E
G
P
K
K
V
V
D
F
H
R
T
S
V
F
D
I
L
S
K
N
---------------
A
A
F
---
G
L
G
---
S
-
A
-
P
G
K
T
W
A
E
K
R
Y
D
L
---
P
Y
I
R
D
F
L
L
D
H
N
M
W
---------
V
D
V
A
E
T
T
V
S
Y
-
A
N
L
----
Q
T
L
W
K
D
A
K
Q
T
F
V
K
H
-----
I
--
P
--
A
W
I
C
A
H
I
S
H
T
Y
T
N
G
----
V
C
L
Y
F
I
--
F
---
A
-
S
K
Q
--------------------------------------------------
R
-
G
W
I
N
V
Y
R
S
L
K
E
T
I
D
P
K
D
I
C
N
P
R
----
44
HHSearch
70.69
20%
-66
- C1 -
3PM9
5
?
A:
[50-476]
----------------------------------------------------------------------------------------------------------------------------------
G
H
S
P
L
V
L
R
P
G
S
T
E
E
V
V
A
I
C
K
L
A
N
E
A
R
V
A
L
V
P
Q
G
G
N
T
G
L
V
G
-
G
Q
T
P
H
----
N
G
E
V
V
I
S
L
K
R
M
D
K
I
R
E
I
D
T
S
S
N
T
I
T
V
E
A
G
A
-------
I
L
Q
R
V
Q
E
K
A
A
E
V
D
R
L
F
P
L
S
L
G
A
Q
G
S
C
---
T
I
G
G
N
L
S
-
T
N
A
G
G
T
A
A
L
A
Y
G
L
A
R
D
M
A
L
G
V
E
V
V
L
A
D
G
R
V
M
--
N
L
LS
K
L
-----------
K
K
D
N
T
G
Y
D
L
R
D
L
F
I
G
A
E
G
T
L
G
I
I
T
A
A
T
L
K
L
F
P
K
P
R
A
--
V
E
T
A
F
V
G
L
Q
S
P
D
D
A
L
---
K
L
L
G
I
A
Q
G
E
A
A
G
N
L
T
S
F
E
L
I
A
E
T
-
P
-
L
-----------
D
F
S
V
R
-------
H
A
----------
N
-------------
N
-------
R
D
P
L
-----------------------
E
--
A
R
--------
Y
P
--------
W
Y
V
L
I
E
L
S
S
P
R
D
D
A
R
A
A
L
E
S
I
L
E
R
G
F
E
D
---------------
G
I
V
V
D
A
A
I
A
NS
V
Q
-
Q
-
Q
Q
A
F
W
K
L
R
E
E
I
S
---
P
A
Q
K
P
----
E
G
G
S
----------
I
K
H
D
I
S
V
P
V
-
A
A
V
----
P
Q
F
I
E
Q
A
N
A
A
V
V
A
L
I
--
P
G
A
--
R
--
P
V
P
F
G
H
L
G
D
----
G
-----
N
I
H
Y
N
--
V
---
S
-
Q
P
V
G
-
A
D
K
A
E
F
-
L
A
R
W
H
D
V
S
Q
V
V
F
E
V
V
L
R
L
G
G
S
I
S
A
E
H
G
I
G
V
M
K
R
D
E
L
A
E
V
K
D
K
-
T
A
I
E
L
M
R
S
I
K
A
L
L
D
P
H
G
I
M
N
P
G
K
V
V
-
46
HHSearch
67.93
18%
-58
- C1 -
1WVF
6
DH4C_PSEPU
A:
[54-513]
---------------------------------------------------------------------------------------------------------------------------------
A
H
A
P
S
A
A
V
T
A
T
T
V
E
Q
V
Q
G
V
V
K
I
C
N
E
H
K
I
P
I
W
T
I
S
T
G
R
N
F
G
Y
G
S
A
A
P
V
Q
R
---
G
Q
V
I
L
D
L
K
K
M
N
K
I
I
K
I
D
P
E
M
C
Y
A
L
V
E
P
G
V
-------
T
F
G
Q
M
Y
D
Y
I
Q
E
N
N
L
P
V
M
L
S
--
F
S
A
P
S
---
A
I
A
G
P
V
G
N
T
M
D
R
G
V
G
Y
T
P
Y
G
E
H
F
M
M
Q
C
G
M
E
V
V
L
A
N
G
D
V
Y
--
R
T
--
G
M
GGVPGSNTWQI
F
K
W
G
Y
G
P
T
L
D
G
M
F
T
--
Q
A
N
Y
G
I
C
T
K
M
G
F
W
L
M
P
K
P
P
V
--
F
K
P
F
E
V
I
F
E
D
E
A
D
I
V
E
I
V
D
A
L
R
P
L
R
M
-
S
N
T
-
I
P
N
S
V
V
I
A
S
T
-
L
W
E
-----------
A
G
S
A
H
LTRAQYT
T
E
----------
P
GHTP---------
D
-------
S
V
I
K
Q
M
Q
K
D
------------------
T
--
G
M
--------
G
A
--------
W
N
L
Y
A
A
L
Y
G
T
Q
E
Q
V
D
V
N
W
K
I
V
T
D
V
F
K
K
L
---------------
G
K
G
---
R
I
V
T
Q-
E
E
A
G
D
T
Q
P
F
K
Y
R
A
Q
L
M
S
GV
P
N
L
Q
E
F
----
G
L
Y
---------
N
W
R
G
G
G
G
S
M
W
F
A
P
V
S
E
AR
G
S
E
C
K
K
Q
A
A
M
A
K
R
V
L
H
K
Y
G
L
--
D
--
Y
V
A
E
F
I
V
A
P
----
R
-----
D
M
H
H
V
ID
V
---
L
-
Y
D
R
T
N
P
---
E
E
-
T
K
R
A
D
A
C
F
N
E
L
L
D
E
F
E
K
E
G
Y
A
V
---
Y
R
V
N
T
R
F
Q
D
R
V
A
Q
S
Y
G
P
-
V
K
R
K
L
E
H
A
I
K
R
A
V
D
P
N
N
I
L
A
P
G
R
S
G
-
10
PsiBlast_PDB
67.08
25%
-65
- C1 -
3PM9
5
?
A:
[58-476]
------------------------------------------------------------------------------------------------------------------------------------------
P
G
S
T
E
E
V
V
A
I
C
K
L
A
N
E
A
R
V
A
L
V
P
Q
G
G
N
T
G
L
V
G
-
G
Q
T
P
--
H
N
G
E
V
V
I
S
L
--
K
R
M
D
K
I
R
E
I
D
T
S
S
N
T
I
T
V
E
A
G
A
I
L
Q
R
V
Q
E
K
A
A
E
V
D
R
L
----------
F
P
L
S
L
G
A
Q
GSC
T
I
G
G
N
L
S
-
T
N
A
G
G
T
A
A
L
A
Y
G
L
A
R
D
M
A
L
G
V
E
V
V
L
A
D
G
R
V
M
N
L
L
S
--
K
L
-----------
K
K
D
N
T
G
Y
D
L
R
D
L
F
I
G
A
E
G
T
L
G
I
I
T
A
A
T
L
K
L
F
P
K
P
R
A
V
E
T
A
F
V
G
L
Q
S
P
D
D
A
L
K
L
---
L
G
I
A
------------------
Q
-
G
-
E
-----------
A
A
G
N
L
-------
T
S
----------
F
-------------
E
-------
L
I
A
E
----
T
------------------
P
--
L
D
--------
F
S
--------
V
---------------
R
H
A
N
N
R
D
P
L
E
A
R
YP
W
Y
V
L
I
E
L
S
S
PRDD
A
R
A
---
A
L
E
---
S
-
I
-
L
E
R
G
F
E
D
G
I
V
V
D
---
A
A
I
A
N
S
V
Q
Q
Q
Q
A
F
W
K
L
R
E
E
ISP
A
Q
K
P
E
G
G
S
I
K
-
H
D
I
----
S
V
P
V
A
A
V
P
Q
F
I
E
Q
A
N
A
A
--------
V
V
A
L
I
P
G
A
R
P
V
P
F
G
HLGD
G
N
I
H
Y
N
--
V
S
Q
P
V
-
G
A
D
K
-
A
---
E
F
-
L
A
R
W
H
D
V
S
Q
V
V
F
E
V
V
L
R
L
G
G
S
I
S
A
E
H
G
I
G
V
M
K
R
D
E
L
-
A
E
V
K
D
K
T
A
I
E
L
M
R
S
I
K
A
L
L
D
P
H
G
I
M
N
P
G
K
V
V
-