@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2378c: (2016-05-10 )
MNPTLAVLGAGAKAVAVAAKASVLRDMGVDVPDVIAVERIGVGANWQASGGWTDGAHRLGTSPEKDVGFPYRSALVPRRNAELDERMTRYSWQSYLIATASFAEWIDRGRPAPTHRRWSQYLAWVADHIGLKVIHGEVERLAVTGDRWALCTHETTVQADALMITGPGQAEKSLLPGNPRVLSIAQFWDRAAGHDRINAERVAVIGGGETAASMLNELFRHRVSTITVISPQVTLFTRGEGFFENSLFSDPTDWAALTFDERRDALARTDRGVFSATVQEALLADDRIHHLRGRVAHAVGRQGQIRLTLSTNRGSENFETVHGFDLVIDGSGADPLWFTSLFSQHTLDLLELGLGGPLTADRLQEAIGYDLAVTDVTPKLFLPTLSGLTQGPGFPNLSCLGLLSDRVLGAGIFTPTKHNDTRRSGEHQSFR
Atome Classification :
(20 SA)
---.........10........20......------..30........40-........50........60...-.-----.-------..---..70........80........90........100........110.......120.....------..130--.-.-.-.-..----.140-----...--.--------....150-----.-----.-------..--...160..----....-.-170....---...180--.----..-..-....190.--..-.-....200.......210.......220--..-....-..230.......240......-.250---......--.260-.......---..270-..-......--------.280-----.---------..-------------....290-..-.-.....300-.---.......310.......-320-------.-.-.......330.......340....-..-.350---.------..-......360.-......370...----------....380.......390..-.....400.......410.......420.......430
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---MNP
T
L
A
V
LGAGA
K
A
V
A
V
A
A
K
A
S
V
L
R
D
M------GVDV
P
D
V
I
A
V
E
R
IG-VGA
N
W
QASGGWTD
G
A
HRLG-TSP-E-----K-------DV---GF
P
Y
R
S
ALVPRRN
A
E
L
D
E
R
M
T
R
Y
S
W
Q
S
Y
L
I
A
T
A
-
S
F
A
E
W
I
DRGRPA
P
T
H
R
R
W
S
Q
Y
L
A
W
V
A
D
------HI
G
L
K
--
V
-
I
-H-G-E
V
----
E
R
L
------
A
VT--G--------D
R
W
A
L
C
T-----H-----E-------
T
T
--
V
QA
D
A
L
M
I
----TGPG-Q-AEKSLLP---GN
P
R
----
V
----
L
S
-
I
A
-
Q
F
W
D
R
A-A--GH-D-RINA
E
R
V
A
V
IGG
G
E
T
A
A
S
M
L
N
E
L
F
R
-H--RV-
S
T
I
T
-
V
ISP
Q
V
T
L
F
TRGEGFFENSLF-SDPT---D
W
A
A
L
T
--
F
D
---
E
R
R
D
A
L
A
---RTD---R
G
-
V
F
S
A
T
V
--------
Q
E
A
L
-----L---------AD-------------D
R
I
H
H
L
--
R
G
-
R
-
V
A
H
AVGR--Q---
G
Q
I
R
L
T
L
STNRGSENF
E
-
T
---------
V
-
H
-
G
F
D
L
V
I
DGSGAD
P
L
W
F
T
S
L
F
S
Q
H
T
-
L
D
-
L
L
-----
E
------LG-LGGPL
T
A
D
R
L
-
Q
E
A
IGY
D
L
A
VTD----------VT
P
K
L
F
L
P
T
L
S
G
LTQGPGF-PN
L
S
C
L
G
L
L
SDRVLGAGIFTPTKHNDTRRSGEHQSFR
21
PsiBlast_CBE
97.91
56%
-108
- C2 -
4D7E
1
?
B:
[3-414]
------
T
L
L
V
V
G
A
G
P
K
A
L
A
V
A
A
K
S
H
V
L
R
Q
L
------
G
L
S
A
P
R
V
I
A
V
E
A
H
A
-
V
G
G
N
W
L
A
S
G
G
W
T
D
G
R
H
R
L
G
-
T
S
P
-
E
-----
K
-------
D
I
---
G
F
P
Y
H
S
T
W
A
R
G
H
N
R
E
I
N
E
A
M
M
A
F
S
W
T
S
F
L
V
E
H
G
-
T
Y
A
E
W
I
D
R
G
R
P
S
P
Q
H
H
V
W
A
K
Y
L
Q
W
V
A
R
------
K
I
D
L
E
--
L
-
V
-
L
-
G
-
K
V
R
T
I
R
Q
R
----------------------
G
W
S
V
E
V
A
G
ADG
A
-----
T
-------
T
E
--
L
E
A
D
G
L
M
I
----
T
G
P
G
-
Q
-
S
T
K
A
-
L
A
---
A
H
P
R
----
V
----
L
S
-
I
A
-
E
F
W
D
L
A
-
G
--
K
R
-
K
-
L
P
I
S
S
R
A
A
V
I
G
G
G
E
T
A
G
S
A
L
D
E
L
V
R
-
H
--
E
M
-
L
T
I
S
-
V
I
S
P
----------
Y
F
E
N
S
L
F
-
S
D
P
T
---
K
W
N
A
L
S
--
I
Q
---
E
R
R
D
V
I
R
---
R
T
D
------
V
F
S
V
R
V
--------
Q
E
S
L
-----
L
---------
G
D
-------------
N
R
V
H
H
L
--
Q
G
-
R
-
V
T
R
I
V
G
Q
--
G
---
D
G
V
A
V
T
L
---------
D
-
Q
---------
V
-
H
-
N
F
D
L
V
V
D
A
T
G
G
Q
P
L
W
F
L
D
L
F
D
S
E
S
-
A
D
-
L
L
-----
E
------
L
A
-
V
G
G
P
L
T
Q
Q
R
I
-
E
S
S
I
G
Y
D
L
A
V
T
G
----------
L
G
A
K
L
Y
L
P
N
M
A
A
L
A
Q
G
P
G
F
-
P
N
L
S
C
L
G
E
L
S
D
R
V
L
R
A
---------------------
44
Fugue
97.88
56%
-103
- C2 -
4D7E
1
?
A:
[1-413]
----
M
E
T
L
L
V
V
G
A
G
P
K
A
L
A
V
A
A
K
S
H
V
L
R
Q
L
------
G
L
S
A
P
R
V
I
A
V
E
A
H
A
-
V
G
G
N
W
L
A
S
G
G
W
T
D
G
R
H
R
L
G
-
T
S
P
-
E
-----
K
-------
D
I
---
G
F
P
Y
H
S
T
W
A
R
G
H
N
R
E
I
N
E
A
M
M
A
F
S
W
T
S
F
L
V
E
H
G
-
T
Y
A
E
W
I
D
R
G
R
P
S
P
Q
H
H
V
W
A
K
Y
L
Q
W
V
A
R
------
K
I
D
L
E
--
L
-
V
-
L
-
G
-
K
V
----
R
T
I
------
R
-
Q
--
G
--------
W
S
V
E
V
A
G
-----
A
-----
T
-------
T
E
--
L
E
A
D
G
L
M
I
----
T
G
P
G
-
Q
-
S
T
K
A
L
-
A
---
A
H
P
R
----
V
----
L
S
-
I
A
-
E
F
W
D
L
A
-
G
--
K
R
-
K
-
L
P
I
S
S
R
A
A
V
I
G
G
G
E
T
A
G
S
A
L
D
E
L
V
R
-
H
--
E
M
-
L
T
I
S
-
V
I
S
P
M
A
S
-------
Y
F
E
N
S
L
F
-
S
D
P
T
---
K
W
N
A
L
S
--
I
Q
---
E
R
R
D
V
I
R
---
R
T
D
---
R
G
-
V
F
S
V
R
V
--------
Q
E
S
L
-----
L
---------
G
D
-------------
N
R
V
H
H
L
--
Q
G
-
R
-
V
T
R
I
V
G
Q
--
G
---
D
G
V
A
V
T
L
R
N
E
M
---
R
A
D
-
Q
---------
V
-
H
-
N
F
D
L
V
V
D
A
T
G
G
Q
P
L
W
F
L
D
L
F
D
S
E
S
-
A
D
-
L
L
-----
E
------
L
A
-
V
G
G
P
L
T
Q
Q
R
I
-
E
S
S
I
G
Y
D
L
A
V
T
G
----------
L
G
A
K
L
Y
L
P
N
M
A
A
L
A
Q
G
P
G
F
-
P
N
L
S
C
L
G
E
L
S
D
R
V
L
----------------------
R
1
PsiBlast_PDB
97.43
56%
-108
- C2 -
4D7E
1
?
A:
[3-413]
------
T
L
L
V
V
G
A
G
P
K
A
L
A
V
A
A
K
S
H
V
L
R
Q
L
------
G
L
S
A
P
R
V
I
A
V
E
A
H
A
-
V
G
G
N
W
L
A
S
G
G
W
T
D
G
R
H
R
L
G
-
T
S
P
-
E
-----
K
-------
D
I
---
G
F
P
Y
H
S
T
W
A
R
G
H
N
R
E
I
N
E
A
M
M
A
F
S
W
T
S
F
L
V
E
H
G
-
T
Y
A
E
W
I
D
R
G
R
P
S
P
Q
H
H
V
W
A
K
Y
L
Q
W
V
A
R
------
K
I
D
L
E
--
L
-
V
-
L
-
G
-
K
V
RTIR
Q
-----------------------
G
W
S
V
E
V
A
G---
A
-----
T
-------
T
E
--
L
E
A
D
G
L
M
I
----
T
G
P
G
-
Q
-
S
T
K
A
-
L
A
---
A
H
P
R
----
V
----
L
S
-
I
A
-
E
F
W
D
L
A
-
G
--
K
R
-
K
-
L
P
I
S
S
R
A
A
V
I
G
G
G
E
T
A
G
S
A
L
D
E
L
V
R
-
H
--
E
M
-
L
T
I
S
-
V
I
S
P
M
A
-------
S
Y
F
E
N
S
L
F
-
S
D
P
T
---
K
W
N
A
L
S
--
I
Q
---
E
R
R
D
V
I
R
---
R
T
D
---
R
G
-
V
F
S
V
R
V
--------
Q
E
S
L
-----
L
---------
G
D
-------------
N
R
V
H
H
L
--
Q
G
-
R
-
V
T
R
I
V
G
Q
--
G
---
D
G
V
A
V
T
L
---
R
N
E
M
R
A
D
-
Q
---------
V
-
H
-
N
F
D
L
V
V
D
A
T
G
G
Q
P
L
W
F
L
D
L
F
D
S
E
S
-
A
D
-
L
L
-----
E
------
L
A
-
V
G
G
P
L
T
Q
Q
R
I
-
E
S
S
I
G
Y
D
L
A
V
T
G
----------
L
G
A
K
L
Y
L
P
N
M
A
A
L
A
Q
G
P
G
F
-
P
N
L
S
C
L
G
E
L
S
D
R
V
L
R
----------------------
22
HHSearch
92.01
52%
-105
- C2 -
4D7E
1
?
A:
[1-413]
----
M
E
T
L
L
V
V
G
A
G
P
K
A
L
A
V
A
A
K
S
H
V
L
R
Q
L
------
G
L
S
A
P
R
V
I
A
V
E
A
H
A
-
V
G
G
N
W
L
A
S
G
G
W
T
D
G
R
H
R
L
G
-
T
S
P
-
E
-----
K
-------
D
I
---
G
F
P
Y
H
S
T
W
A
R
G
H
N
R
E
I
N
E
A
M
M
A
F
S
W
T
S
F
L
V
E
H
G
-
T
Y
A
E
W
I
D
R
G
R
P
S
P
Q
H
H
V
W
A
K
Y
L
Q
W
V
A
R
------
K
I
D
L
E
--
L
-
V
L
G
---
K
V
----
R
T
I
------
R
Q
-------------
G
W
S
V
E
V
-----
A
GA---
T
-------
T
E
--
L
E
A
D
G
L
M
I
T
---
G
P
G
Q
-
S
-
T
--
K
A
L
A
---
A
H
P
R
----
V
----
L
S
-
I
A
-
E
F
W
D
L
A
-
G
--
K
R
-
K
-
L
P
I
S
S
R
A
A
V
I
G
G
G
E
T
A
G
S
A
L
D
E
L
V
R
-
H
--
E
M
-
L
T
I
S
-
V
I
S
P
M
A
-------
S
Y
F
E
N
S
L
F
-
S
D
P
T
---
K
W
N
A
L
S
--
I
Q
---
E
R
R
D
V
I
R
---
R
T
D
---
R
G
-
V
F
S
V
R
V
--------
Q
E
S
L
-----
L
---------
G
D
-------------
N
R
V
H
H
L
---
Q
-
G
R
V
T
R
I
V
G
Q
--
G
---
D
G
V
A
V
T
L
R
N
E
-
M
--
R
A
D
-
Q
---------
V
-
H
-
N
F
D
L
V
V
D
A
T
G
G
Q
P
L
W
F
L
D
L
F
D
S
E
S
-
A
D
-
L
L
-----
E
L
A
V
GGP
L
T
-
Q
Q
R
I
E
S
S
I
G
Y
-
D
L
A
V
T
------
G
----------
L
G
A
K
L
Y
L
P
N
M
A
A
L
A
Q
G
P
G
F
-
P
N
L
S
C
L
G
E
L
S
D
R
V
L
R
----------------------
25
HHSearch
64.48
19%
-83
* C2 *
4TM3
16
?
A:
[30-442]
----
T
H
D
V
V
G
V
G
F
G
P
A
N
L
S
L
A
V
A
L
E
E
S
P
-
A
------
A
L
---
T
S
A
F
F
E
R
R
A
S
I
S
W
H
Q
G
M
---
L
L
P
A
-
A
K
M
Q
-
V
S
F
-
L
----------------------
K
D
L
A
T
------
F
R
N
P
A
S
R
F
S
F
V
S
F
L
H
E
R
G
-
R
L
V
R
F
A
N
N
H
D
F
F
P
T
R
R
E
F
H
D
Y
L
E
W
A
E
S
------
K
L
A
H
E
--
V
-
S
Y
D
-
S
-
E
V
----
T
A
I
------
R
P
G
--
P
GRPV----
D
S
V
L
V
D
V
-----
S
T
PE
A
-
T
-------
R
T
--
V
E
A
R
N
I
V
I
S
---
T
G
L
V
-
P
-
R
M
P
-
A
G
V
---
Q
S
D
E
F---
V
----
W
H
-
S
S
-
R
F
L
D
H
F
-
R
--
D
R
-
D
-
P
R
S
L
R
R
V
A
V
A
G
G
G
Q
S
A
A
E
I
V
R
F
L
H
D
-
N
--
R
P
D
T
V
V
H
-
A
I
M
P
S
Y
G
Y
V
V
A
D
N
T
P
F
A
N
Q
I
F
--
D
P
A
A
V
D
D
Y
F
D
G
S
--
K
Q
---
A
K
D
A
F
W
R
---
Y
H
R
NTN
Y
S
-
V
V
D
D
E
V
--------
I
R
D
L
-----
Y
R
R
G
Y
D
D
E
V
A
G
A
-------------
P
R
L
N
F
V
--
N
L
-
A
H
V
V
G
A
K
R
I
--
A
---
D
D
T
R
V
T
V
Y
S
M
A
R
--
E
E
S
-
Y
---------
D
-
L
-
D
V
D
V
L
V
C
A
T
G
Y
D
P
M
D
P
G
D
L
L
G
E
L
A
-
E
H
--
C
-----
V
------
Q
D
A
E
G
R
W
Q
V
D
R
D
Y
-
R
M
V
T
T
-----
P
D
----------
L
R
C
G
I
Y
L
Q
G
G
T
E
H
T
H
G
L
S
S
-
S
L
L
S
N
L
A
T
R
S
G
E
I
V
S
S
I
E
R
R
K
----------------
23
HHSearch
62.70
17%
-91
- C2 -
4B63
8
SIDA_ASPFU
A:
[39-486]
----
L
H
D
L
L
C
V
G
F
G
P
A
S
L
A
I
A
I
A
L
H
D
A
L
D
P
RLNKSA--
A
Q
P
K
I
C
F
L
E
R
Q
K
Q
F
A
--
W
H
S
G
-
M
L
V
P
G
-
S
K
M
Q
-
I
S
F
-
I
----------------------
K
D
L
A
T
------
L
R
D
P
R
S
S
F
T
F
L
N
Y
L
H
Q
K
G
-
R
L
I
H
F
T
N
L
S
T
F
L
P
A
R
L
E
F
E
D
Y
M
R
W
C
A
Q
------
Q
F
S
D
V
--
V
-
A
Y
G
-
E
-
E
V
----
V
E
V
------
I
P
G
--
K
SDPSSSVV
D
F
F
T
V
R
S
-----
R
-----
N
VETG
E
I
-
S
A
--
R
R
T
R
K
V
V
I
A---
I
G
G
T
-
A
-
K
M
P
S
G
L
P
---
Q
D
P
R
----
I
----
I
H
-
S
S
-
K
Y
C
T
T
L
P
A
--
L
L
K
D
-
K
S
K
P
Y
N
I
A
V
L
G
S
G
Q
S
A
A
E
I
F
H
D
L
Q
K
-
R
Y
P
N
--
S
R
T
T
-
L
I
M
R
D
S
A
M
R
P
S
D
D
S
P
F
V
N
E
I
F
--
N
P
E
R
V
D
K
F
Y
S
Q
S
--
A
A
---
E
R
Q
R
S
L
L
A
D
K
A
T
N
---
Y
S
-
V
V
R
L
E
L
I
E
E
I
Y
N
D
M
Y
L
Q
R
V
K
NPD
E
---------
T
Q
-------------
W
Q
H
R
I
L
--
P
E
-
R
K
I
T
R
V
E
H
H
GP
Q
---
S
R
M
R
I
H
L
K
S
S
K
P
---
V
K
-
E
---------
T
-
L
-
E
V
D
A
L
M
V
A
T
G
Y
N
R
N
A
H
E
R
L
L
S
K
V
Q
--
H
-
L
R
PTGQD
Q
------
W
K
P
H
R
D
Y
R
V
E
M
D
P
-
S
K
V
S
------------------
S
E
A
G
I
W
L
Q
G
C
N
E
R
T
H
G
L
S
D
-
S
L
L
S
V
L
A
V
R
G
G
E
M
V
Q
S
I
F
G
E
Q
----------------
45
Fugue
55.69
20%
-66
- C2 -
3S5W
5
PVDA_PSEAE
A:
[29-448]
---
V
V
H
D
L
I
G
V
G
F
G
P
S
N
I
A
L
A
I
A
L
Q
E
R
A
Q
A
------
Q
-
G
A
L
E
V
L
F
L
D
K
--------
Q
G
D
Y
R
W
H
G
N
T
L
V
S
Q
-
S
E
L
-
Q
-------------------
I
S
F
L
K
D
L
V
S
L
R
N
P
T
-----
S
P
Y
S
F
V
N
Y
L
H
K
H
D
-
R
L
V
D
F
I
N
L
G
T
F
Y
P
C
R
M
E
F
N
D
Y
L
R
W
V
A
S
H
F
Q
EQS
R
Y
G
E
E
--
V
-
L
-
R
-
I
-
E
P
----
M
L
S
------
A
G
Q
--
V
--------
E
A
L
R
V
I
S
-----
R
N
ADG
E
E
-------
L
V
--
R
T
T
R
A
L
V
V
S
PGG
T
P
R
I
-
P
-
Q
V
F
R
A
L
K
---
G
D
G
R
----
V
----
F
H
-
H
S
-
Q
Y
L
E
H
M
-
A
---------
K
P
M
K
I
A
I
I
G
G
G
Q
S
A
A
E
A
F
I
D
L
N
D
S
Y
--
P
S
-
V
Q
A
D
-
M
I
L
R
A
S
A
L
K
P
A
D
D
S
P
F
V
N
E
V
F
A
P
K
F
T
---
D
L
I
Y
S
R
--
E
H
---
A
E
R
E
R
L
L
---
R
E
Y
---
H
N
-
T
N
Y
S
V
V
--------
D
T
D
L
-----
I
---------
E
R
-------------
I
Y
G
V
F
Y
--
R
Q
-
K
-
V
S
-----------
G
I
P
R
H
A
F
R
C
M
T
T
V
E
R
A
T
-
A
---------
T
A
Q
-
G
I
E
L
A
L
R
D
A
G
S
G
E
------
L
S
V
E
T
-
Y
D
-
A
V
-----
I
------
L
A
-
T
G
Y
E
R
Q
L
R
Q
L
-
L
E
P
L
A
E
Y
L
G
E
I
G
RDYRLQTDER
C
K
V
A
I
Y
A
Q
G
F
S
Q
A
S
H
G
L
S
D
-
T
L
L
S
V
L
P
V
R
A
E
E
I
S
G
S
L
Y
Q
H
L
K
---------------
34
HHSearch
51.88
18%
-94
- C2 -
4USQ
1
?
A:
[13-357]
----
S
T
D
I
V
I
I
G
G
G
Q
A
A
L
S
V
A
Y
Y
L
---
R
R
S
------
K
Y
---
S
F
V
M
L
D
A
E
Q
T
P
G
G
A
W
L
H
G
--
W
D
-
S
L
-
R
L
F
-
S
P
---------------------------
S
T
-------------
W
S
S
L
S
G
W
Q
M
------
P
---
P
T
G
E
T
Y
P
S
R
D
Q
V
V
D
Y
L
R
H
Y
E
S
------
R
Y
E
F
P
--
V
-
Q
R
P
-
V
-
W
V
----
S
A
V
------
N
N
L
--
G
--------
D
R
L
E
V
V
S
-----
E
-----
R
-------
Q
Q
--
W
R
A
R
V
V
I
S
A---
T
G
T
W
-
R
N
P
F
I
P
A
Y
P
---
G
A
D
L
---------
F
Q
-
G
A
--
Q
L
H
S
A
-
H
YQ
S
P
-
A
-
P
F
A
G
Q
K
V
L
V
V
G
G
G
N
S
G
A
Q
I
L
A
E
V
S
R
-
V
--
A
---
D
C
T
-
W
V
T
T
S
E
P
I
F
L
P
D
D
V
D
-
G
R
V
L
F
---
Q
R
---
A
T
D
R
W
K
--
A
----------------------D
V
V
M
V
P
P
--------
V
K
E
A
-----
R
---------
E
R
-------------
G
A
L
H
A
V
--
R
--
P
-
F
T
R
F
T
A
-------
N
G
V
V
W
A
-----
D
----
G
-
T
---------
G
-
S
-
A
V
D
A
V
I
W
C
T
G
F
R
P
A
L
--
A
H
L
Q
S
L
-----
G
V
-----
I
------
N
P
-
D
G
K
V
D
L
A
G
T
R
-
S
L
Q
--------------------
E
P
R
L
W
L
L
G
Y
G
E
W
T
G
L
A
S
A
--
T
L
I
G
V
G
R
S
A
R
A
T
A
E
E
I
I
Q
Y
-----------------
30
HHSearch
51.67
19%
-86
- C2 -
3D1C
6
BVMO_STAAM
A:
[3-312]
---
Q
H
H
K
V
A
I
I
G
A
G
A
A
G
I
G
M
A
I
T
L
---
K
D
F
------
G
I
--
T
D
V
I
I
L
E
K
G
T
-
V
G
H
S
F
K
H
W
---
P
K
S
T
R
T
I
--
T
P
-----------------------
S
F
T
S
N
--------------
G
F
G
M
P
D
M
N
A
I
S
M
D
T
S
P
A
F
T
-
F
N
E
E
H
I
S
G
E
T
Y
A
E
Y
L
Q
V
V
A
N
------
H
Y
E
L
N
--
I
-
F
E
N
-
T
-
V
V
----
T
N
I
------
S
A
D
--
D
--------
A
Y
Y
T
I
A
T
-----
T
-----
T
-------
E
T
--
Y
H
A
D
Y
I
F
V
A---
T
G
D
Y
-
N
--
F
P
-
K
K
P
---
F
K
Y
G
----
I
-----
H
-
Y
S
-
E
I
E
D
-------
F
-
D
-
N
F
N
K
G
Q
Y
V
V
I
G
G
N
E
S
G
F
D
A
A
Y
Q
L
A
K
-
N
--
G
--
S
D
I
A
-
L
Y
T
S
--------------------
P
S
---
V
--
R
L
S
--
P
Y
---
T
R
Q
R
L
G
-----------------------------
N
V
-----
I
---------
K
Q
--------------
G
A
R
I
E
M
N
V
H
Y
T
-
V
K
D
I
D
F
N
--
N
---
G
Q
Y
H
I
S
F
D
---
S
----
G
Q
S
---------
V
-
H
-
T
P
H
E
P
I
L
A
T
G
F
D
A
T
K
N
-
P
I
V
Q
Q
L
-----
F
V
-----
T
------
T
--
N
Q
D
I
K
L
T
T
H
D
E
S
T
R
--------------------
Y
P
N
I
F
M
I
G
A
T
V
E
N
-------------------------------------------
49
Fugue
50.92
24%
-54
- C2 -
4USR
2
?
A:
[1-357]
GPA
M
P
P
I
L
D
V
I
V
I
G
G
-
G
Q
A
A
L
T
T
A
Y
F
L
R
R
T
------
S
L
S
--
Y
L
L
L
D
E
Q
P
G
-
P
G
------
G
A
W
L
H
A
W
D
S
L
R
L
F
S
P
-
A
-----
A
-------
W
S
SIA
G
W
P
M
P
S
P
T
E
P
G
N
----------------------------------
P
T
R
N
D
V
I
D
Y
L
R
R
Y
E
D
------
R
Y
Q
F
P
--
I
-
Q
-
R
-
P
V
R
V
----
D
T
V
------
T
R
L
--
D
--------
D
L
W
R
V
Q
A
-----
G
-----
D
-------
Q
Q
--
W
L
A
R
A
V
-
I
----
S
A
T
G
-
T
-
W
S
K
P
F
I
P
PYE
G
R
E
L
----
F
----
Q
G
-
A
Q
-
I
H
S
A
H
Y
-
R
--
T
P
-
A
-
P
F
A
G
K
R
V
M
V
V
G
G
G
N
S
G
A
Q
V
L
A
E
L
S
S
-----
V
-
S
E
T
L
-
W
I
T
Q
E
-----------
P
P
A
F
L
-
P
D
E
V
---
D
--
G
R
V
--
L
F
---
E
R
A
T
A
R
W
---
K
A
Q
--------------------
Q
E
G
R
-----
S
---------
I
D
-------------
E
P
A
G
G
F
--
G
D
-
I
-
V
M
V
P
P
V
R
--
E
---
A
R
E
R
G
V
L
V
A
E
R
P
F
A
R
F
T
-
E
T
G
V
E
W
ADG
R
R
-
E
-
N
L
D
A
V
I
W
C
S
G
F
R
P
A
L
------
D
H
L
-
R
E
-
L
G
-----
V
------
V
E
-
A
D
G
K
V
Q
V
E
---------
D
T
R
V
V
K
-----------
Q
P
N
L
W
L
V
---------
G
Y
-
G
D
W
T
--
G
M
A
S
A
T
L
I
G
V
T
R
T
A
R
S
T
A
D
Q
V
V
Q
A
L
T
A
T
P
--
38
HHSearch
48.83
13%
-91
- C2 -
2XVE
1
?
A:
[3-340]
-----
T
R
I
A
I
L
G
A
G
P
S
G
M
A
Q
L
R
A
F
Q
S
A
Q
E
K
------
G
A
E
I
P
E
L
V
C
F
E
K
Q
A
D
W
G
G
Q
W
N
Y
T
--
W
R
T
G
L
D
E
N
G
-
E
P
----------------
V
H
---
S
S
M
Y
R
Y
L
W
S
-------
N
G
P
K
E
C
L
E
F
A
D
Y
T
F
D
E
H
-----
F
G
K
P
I
A
S
Y
P
P
R
E
V
L
W
D
Y
I
K
G
R
V
E
------
K
A
G
V
R
KY
I
R
F
-
N
-
T
-
A
V
----
R
H
V
------
E
F
N
ED
S
--------
Q
T
F
T
V
T
V
-----
Q
-----
D
HTTD
T
I
-
Y
S
--
E
E
F
D
Y
V
V
C
C---
T
G
H
F
S
T
-
P
Y
V
P
E
F
E
---
G
F
E
K
FG
G
R
I
----
L
H
-
A
H
-
D
F
R
D
-------
A
-
L
-
E
F
K
D
K
T
V
L
L
V
G
S
S
Y
S
A
E
D
I
G
S
Q
C
Y
K
-
Y
--
G
--
A
K
K
L
-
I
S
C
Y
R
T
A
P
M
--------------
G
Y
K
-------
W
P
--
E
------------------------------------------------------------------------
N
W
D
-
E
--
R
P
-
N
-
L
V
R
V
D
T
-------
E
N
A
Y
F
A
-----
D
----
G
-
S
---------
S
-
E
-
K
V
D
A
I
I
L
C
T
G
Y
I
H
H
F
--
P
F
L
N
D
D
L
----
R
L
-----
V
------
T
N
-
N
R
L
W
P
L
N
L
Y
K
-
G
V
V
-------
W
E
----------
D
N
P
K
F
F
Y
I
G
M
Q
D
Q
W
Y
-
S
F
N
-
M
F
D
A
Q
A
W
Y
A
R
D
V
I
M
G
R
L
--------------------
6
PsiBlast_PDB
48.82
23%
-79
- C2 -
4TM0
5
?
A:
[96-368]
------------------------------------------------------------------------------------------------------------------
S
R
F
S
F
V
S
F
L
H
E
R
G
-
R
L
V
R
F
A
N
N
H
D
F
F
P
T
R
R
E
F
H
D
Y
L
E
W
A
E
S
------
K
L
A
H
E
--
V
-
S
-
Y
D
S
-
E
V
----
T
A
I
R
P
G
P
GR
P
V
D
--
S
--------
V
L
V
D
V
S
T
-----
P
-----
E
-------
A
T
R
T
V
E
A
R
N
I
V
I
S
---
T
G
L
V
-
P
-
R
M
P
A
G
V
Q
---
S
D
E
F
----
V
----
W
H
-
S
S
-
R
F
L
D
H
F
-
R
--
D
R
-
D
-
P
R
S
L
R
R
V
A
V
A
G
G
G
Q
S
A
A
E
I
V
R
F
L
H
D
-
N
--
R
P
-
D
T
V
V
H
A
I
M
P
S
Y
G
Y
V
V
A
D
N
T
P
F
A
N
Q
I
F
--------
D
P
A
A
V
D
D
Y
F
D
GS
K
Q
A
K
D
A
F
W
---
R
Y
H
---
R
N
-
T
N
Y
S
V
V
--------
D
D
E
V
-----
I
---------
R
D
L
Y
R
R
G
Y
D
D
E
V
A
GA
P
R
L
N
F
V
-----
N
-
L
A
H
V
V
G
A
--
K
R
I
A
D
D
T
R
V
T
V
Y
S
M
A
R
E
E
S
Y
D
-
L
-------------
D
V
D
V
L
V
C
A
T
G
Y
D
P
M
-------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
48.70
23%
-76
- C2 -
4TM4
15
?
A:
[96-368]
------------------------------------------------------------------------------------------------------------------
S
R
F
S
F
V
S
F
L
H
E
R
G
-
R
L
V
R
F
A
N
N
H
D
F
F
P
T
R
R
E
F
H
D
Y
L
E
W
A
E
S
------
K
L
A
H
E
--
V
-
S
-
Y
D
S
-
E
V
----
T
A
I
R
P
G
P
GR
P
V
D
--
S
--------
V
L
V
D
V
S
T
-----
P
-----
E
-------
A
T
R
T
V
E
A
R
N
I
V
I
S
---
T
G
L
V
-
P
-
R
M
P
A
G
V
Q
---
S
D
E
F
----
V
----
W
H
-
S
S
-
R
F
L
D
H
F
-
R
--
D
R
-
D
-
P
R
S
L
R
R
V
A
V
A
G
G
G
Q
S
A
A
E
I
V
R
F
L
H
D
-
N
--
R
P
-
D
T
V
V
H
A
I
M
P
S
Y
G
Y
V
V
A
D
N
T
P
F
A
N
Q
I
F
--------
D
P
A
A
V
D
D
Y
F
D
GS
K
Q
A
K
D
A
F
W
---
R
Y
H
---
R
N
-
T
N
Y
S
V
V
--------
D
D
E
V
-----
I
---------
R
D
L
Y
R
R
G
Y
D
D
E
V
A
GA
P
R
L
N
F
V
-----
N
-
L
A
H
V
V
G
A
--
K
R
I
A
D
D
T
R
V
T
V
Y
S
M
A
R
E
E
S
Y
D
-
L
-------------
D
V
D
V
L
V
C
A
T
G
Y
D
P
M
-------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
48.28
23%
-72
- C2 -
4TLZ
6
?
A:
[96-368]
------------------------------------------------------------------------------------------------------------------
S
R
F
S
F
V
S
F
L
H
E
R
G
-
R
L
V
R
F
A
N
N
H
D
F
F
P
T
R
R
E
F
H
D
Y
L
E
W
A
E
S
------
K
L
A
H
E
--
V
-
S
-
Y
D
S
-
E
V
----
T
A
I
R
P
G
P
GR
P
V
D
--
S
--------
V
L
V
D
V
S
T
-----
P
-----
E
-------
A
T
R
T
V
E
A
R
N
I
V
I
S---
T
G
L
V
-
P
-
R
M
P
A
G
V
Q
---
S
D
E
F
----
V
----
W
H
-
S
S
-
R
F
L
D
H
F
-
R
--
D
R
-
D
-
P
R
S
L
R
R
V
A
V
A
G
G
G
Q
S
A
A
E
I
V
R
F
L
H
D
-
N
--
R
P
-
D
T
V
V
H
A
I
M
P
S
Y
G
Y
V
V
A
D
N
T
P
F
A
N
Q
I
F
--------
D
P
A
A
V
D
D
Y
F
D
GS
K
Q
A
K
D
A
F
W
---
R
Y
H
---
R
N
-
T
N
Y
S
V
V
--------
D
D
E
V
-----
I
---------
R
D
L
Y
R
R
G
Y
D
D
E
V
A
GA
P
R
L
N
F
V
-----
N
-
L
A
H
V
V
G
A
--
K
R
I
A
D
D
T
R
V
T
V
Y
S
M
A
R
E
E
S
Y
D
-
L
-------------
D
V
D
V
L
V
C
A
T
G
Y
D
P
M
-------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
48.21
23%
-70
- C2 -
4TM3
13
?
A:
[96-368]
------------------------------------------------------------------------------------------------------------------
S
R
F
S
F
V
S
F
L
H
E
R
G
-
R
L
V
R
F
A
N
N
H
D
F
F
P
T
R
R
E
F
H
D
Y
L
E
W
A
E
S
------
K
L
A
H
E
--
V
-
S
-
Y
D
S
-
E
V
----
T
A
I
R
P
G
P
GR
P
V
D
--
S
--------
V
L
V
D
V
S
T
-----
P
-----
E
-------
A
T
R
T
V
E
A
R
N
I
V
I
S
---
T
G
L
V
-
P
-
R
M
P
A
G
V
Q
---
S
D
E
F
----
V
----
W
H
-
S
S
-
R
F
L
D
H
F
-
R
--
D
R
-
D
-
P
R
S
L
R
R
V
A
V
A
G
G
G
Q
S
A
A
E
I
V
R
F
L
H
D
-
N
--
R
P
-
D
T
V
V
H
A
I
M
P
S
Y
G
Y
V
V
A
D
N
T
P
F
A
N
Q
I
F
--------
D
P
A
A
V
D
D
Y
F
D
GS
K
Q
A
K
D
A
F
W
---
R
Y
H
---
R
N
-
T
N
Y
S
V
V
--------
D
D
E
V
-----
I
---------
R
D
L
Y
R
R
G
Y
D
D
E
V
A
GA
P
R
L
N
F
V
-----
N
-
L
A
H
V
V
G
A
--
K
R
I
A
D
D
T
R
V
T
V
Y
S
M
A
R
E
E
S
Y
D
-
L
-------------
D
V
D
V
L
V
C
A
T
G
Y
D
P
M
-------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
47.70
23%
-74
- C2 -
4TLX
6
?
A:
[96-368]
------------------------------------------------------------------------------------------------------------------
S
R
F
S
F
V
S
F
L
H
E
R
G
-
R
L
V
R
F
A
N
N
H
D
F
F
P
T
R
R
E
F
H
D
Y
L
E
W
A
E
S
------
K
L
A
H
E
--
V
-
S
-
Y
D
S
-
E
V
----
T
A
I
R
P
G
P
GR
P
V
D
--
S
--------
V
L
V
D
V
S
T
-----
P
-----
E
-------
A
T
R
T
V
E
A
R
N
I
V
I
S
---
T
G
L
V
-
P
-
R
M
P
A
G
V
Q
---
S
D
E
F
----
V
----
W
H
-
S
S
-
R
F
L
D
H
F
-
R
--
D
R
-
D
-
P
R
S
L
R
R
V
A
V
A
G
G
G
Q
S
A
A
E
I
V
R
F
L
H
D
-
N
--
R
P
-
D
T
V
V
H
A
I
M
P
S
Y
G
Y
V
V
A
D
N
T
P
F
A
N
Q
I
F
--------
D
P
A
A
V
D
D
Y
F
D
GS
K
Q
A
K
D
A
F
W
---
R
Y
H
---
R
N
-
T
N
Y
S
V
V
--------
D
D
E
V
-----
I
---------
R
D
L
Y
R
R
G
Y
D
D
E
V
A
GA
P
R
L
N
F
V
-----
N
-
L
A
H
V
V
G
A
--
K
R
I
A
D
D
T
R
V
T
V
Y
S
M
A
R
E
E
S
Y
D
-
L
-------------
D
V
D
V
L
V
C
A
T
G
Y
D
P
M
-------------------------------------------------------------------------------------------------------------------------
43
HHSearch
47.65
15%
-79
- C2 -
2GV8
4
FMO1_SCHPO
A:
[6-361]
----
I
R
K
I
A
I
I
G
A
G
P
S
G
L
V
T
A
K
A
L
L
A
E
K
-
A
------
F
D
---
Q
V
T
L
F
E
R
R
G
S
P
G
G
V
W
N
Y
T
S
T
L
S
N
K
L
P
V
P
S
-
T
N
P
I
L
T
T
E
P
I
V
GPAAL
P
V
Y
P
---
S
P
L
Y
R
D
L
Q
T
N
T
-------
P
I
E
L
M
G
Y
C
D
Q
S
F
---------
K
P
Q
T
L
Q
F
P
H
R
H
T
I
Q
E
Y
Q
R
I
Y
A
Q
------
P
L
L
P
F
--
I
K
L
-
A
-
T
-
D
V
----
L
D
I
------
E
K
K
--
D
--------
G
S
W
V
V
T
Y
-----
K
-----
G
TKAG
S
P
I
S
K
--
D
I
F
D
A
V
S
I
C---
N
G
H
Y
-
E
V
P
Y
I
P
N
I
K
---
G
L
D
E
----
Y
----
A
K
A
V
P
G
S
V
L
H
S
S
-
L
FR
E
P
-
E
-
L
F
V
G
E
S
V
L
V
V
G
G
A
S
S
A
N
D
L
V
R
H
L
T
P
-
V
--
A
--
K
H
P
I
-
Y
Q
S
L
L
G
------------------
G
G
------
D
I
------------------------------------------------------------
Q
N
-------------
E
S
L
Q
Q
V
---
P
-
E
-
I
T
K
F
D
P
T
--
T
---
R
E
I
Y
L
K
-----
G
----
G
-
K
---------
V
-
L
S
N
I
D
R
V
I
Y
C
T
G
Y
L
Y
S
V
--
P
F
P
S
L
A
K
L
K
S
P
E
T
-----
K
------
L
I
D
D
G
S
H
V
H
N
V
Y
Q
-
H
I
F
Y
-------
I
----------
P
D
P
T
L
A
F
V
G
L
A
L
H
V
V
--
P
F
P
T
S
Q
A
Q
A
A
F
L
A
R
V
W
S
G
R
L
--------------------
7
PsiBlast_PDB
47.42
23%
-76
- C2 -
4TM1
14
?
A:
[96-368]
------------------------------------------------------------------------------------------------------------------
S
R
F
S
F
V
S
F
L
H
E
R
G
-
R
L
V
R
F
A
N
N
H
D
F
F
P
T
R
R
E
F
H
D
Y
L
E
W
A
E
S
------
K
L
A
H
E
--
V
-
S
-
Y
D
S
-
E
V
----
T
A
I
R
P
G
P
GR
P
V
D
--
S
--------
V
L
V
D
V
S
T
-----
P
-----
E
-------
A
T
R
T
V
E
A
R
N
I
V
I
S
---
T
G
L
V
-
P
-
R
M
P
A
G
V
Q
---
S
D
E
F
----
V
----
W
H
-
S
S
-
R
F
L
D
H
F
-
R
--
D
R
-
D
-
P
R
S
L
R
R
V
A
V
A
G
G
G
Q
S
A
A
E
I
V
R
F
L
H
D
-
N
--
R
P
-
D
T
V
V
H
A
I
M
P
S
Y
G
Y
V
V
A
D
N
T
P
F
A
N
Q
I
F
--------
D
P
A
A
V
D
D
Y
F
D
GS
K
Q
A
K
D
A
F
W
---
R
Y
H
---
R
N
-
T
N
Y
S
V
V
--------
D
D
E
V
-----
I
---------
R
D
L
Y
R
R
G
Y
D
D
E
V
A
GA
P
R
L
N
F
V
-----
N
-
L
A
H
V
V
G
A
--
K
R
I
A
D
D
T
R
V
T
V
Y
S
M
A
R
E
E
S
Y
D
-
L
-------------
D
V
D
V
L
V
C
A
T
G
Y
D
P
M
-------------------------------------------------------------------------------------------------------------------------
42
HHSearch
46.84
22%
-105
- C2 -
4C5O
4
?
A:
[2-218]
---
D
S
V
D
V
V
V
I
G
G
G
Q
S
G
L
S
A
G
Y
F
L
---
R
R
S
-------
L
---
S
Y
V
I
L
D
A
E
A
S
P
G
G
A
W
Q
H
A
--
W
H
S
L
H
L
--
F
-
S
P
A
---------------------------
G
-
W
------------
S
S
I
P
G
W
P
M
------
P
A
S
---
Q
G
P
Y
P
A
R
A
E
V
L
A
Y
L
A
Q
Y
E
Q
------
K
Y
A
L
P
--
V
L
R
-
P
-
I
-
R
V
----
Q
R
V
------
S
H
F
--
G
--------
E
R
-
R
V
V
A
-----
R
D----
G
-------
R
Q
--
W
-
A
R
A
V
I
S
A---
T
G
T
W
-
G
E
A
Y
T
P
E
Y
Q
---
G
L
E
S
----
F
A
G
I
Q
L
H
-
S
A
-
H
Y
S
T
-------
P
-
A
-
P
F
A
G
M
R
V
A
I
I
G
G
G
N
S
G
A
Q
I
L
A
E
V
S
T
-
V
-----
A
E
T
T
-
W
I
T
R
T
E
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
46.78
14%
-90
- C2 -
3KLJ
1
NROR_CLOAB
A:
[9-271]
----
S
T
K
I
L
I
L
G
A
G
P
A
G
F
S
A
A
K
A
A
---
L
G
K
------
C
D
---
D
I
T
M
I
N
S
E
K
Y
L
P
Y
-
Y
R
P
------
R
---------------------------------------------------
L
N
--
E
I
I
A
--------------
K
N
K
S
I
D
D
I
L
I
K
K
N
D
W
Y
E
------
K
N
N
I
K
--
V
-
I
T
S
-
E
-
F
A
----
T
S
I
------
D
P
N
--
N
--------
K
--
L
V
T
L
-----
K
S----
G
-------
E
K
--
I
K
Y
E
K
L
I
I
A---
S
G
S
I
-
A
-
N
K
I
K
-
V
P
---
H
A
D
E
----
I
----
F
S
-
L
Y
-
S
Y
D
D
A
L
-
K
--
I
K
-
D
E
C
K
N
K
G
K
A
F
I
I
G
G
G
I
L
G
I
E
L
A
Q
A
I
I
D
-
S
--
G
--
T
P
A
S
-
I
G
I
I
L
E
Y
P
L
E
R
Q
---------------------
L
D
--
R
D
---
G
G
L
F
-----------------------------
L
K
D
K
-----
L
---------
D
R
-------------
L
G
I
K
I
Y
--
T
N
-
S
N
F
E
E
M
-------------------------
G
-
D
---------
L
-
I
-
R
S
S
C
V
I
T
A
V
G
V
K
P
N
L
--
D
F
I
K
D
T
-----
E
I
-----
A
------
S
--
K
R
G
I
L
V
N
D
H
M
-
E
T
S
--------------------
I
K
D
I
Y
A
C
G
D
V
A
E
F
Y
G
-----------------------------------------