@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
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Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2380c: (2016-05-10 )
MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPTVHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVLLLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTTEADLNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPPGIECERYDLRSNITQLPLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLALMDERDAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLVLRTPVRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTETVINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLTRVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREIGGVPHQIIQPPAEVPVRCAAGSDAAWLRAELNNERGYVFDLETDWPIRAALLSTPEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSALLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQDHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDEYRGHVIYRTELYERATAQRFADWLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNAGAGTARVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGERGVWKADGQLELLAEIERLPTAQAAPVPAEPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDGGIPLTARMVFEHPVLCELAAAVDAKPHVEAEPDDKHHAPMSTSGLSPDELSALTASWDQWP
Atome Classification :
(26 SA)
.........10........20.......-.-30........40........50.......--------.60-.........70.........80........90........100-.......110.......120.......130.......140.-----......150...-.-...160.--------..----...--------.170.......180...----....190.......200..-------.....210.......220........230.......240.......250.......-260--........270.......280.......290.......300.......310.....----..320.......330.......340-------..--------------...------.---...350....-...360......-.370.....-..380..-------.....390.......400.......410.....-..420.......430......-.440.......450.......460........470.......480.......490.......500.......510.......520.......530....-...540-------...--------..-------..--.------550-.-------..-----.----------------.---.---------..-------.560.-------.-.----.---.------..570.......580.......590.......600..---.....610.......620.......630.....-..-640---.......650.......660...--------....670...--...----.680.--.---.....--690.--......700.....-.---.710.........720.......---730--.----.....----..740.-......750.-......760........770.......780.......--790..-.-...-.800.......810.......820.......830.......840.......850--.....------.-..860--.....-...870.......880.......890.......900.....-..910.......920....---...-930-........940.......950.......960.......970.......980..-.....990.......1000......1010......1020......1030......1040......1050......1060.-.....1070......1080......-1090......1100..--....1110---.........1120......1130......1140-......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300........1310......1320......1330......1340......1350......1360......1370......1380...---------...1390......1400......1410-......1420......1430......1440......1450......1460......1470-----------------------------------------------------.-----------------------------------------------------------------..---------.-----------.---------------------------------------------------------------------------------------------------------------------------------------------------------------------.----------------------------------------------------------------------------------------------------------------------------------------------------------------.1480......1490......1500......1510......1520......1530......1540......1550......1560...---------------------------------------------------------------------------------------------.-------------------------------------------------------..1570......1580......1590......1600......1610......1620.......1630......1640......1650......1660......1670......1680
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
W
F
V
Q
MADPS
G
A
L
L
N
I
C
V
S
Y
R
ITGD
I
D
L
-
A
-
R
L
R
D
A
V
N
A
V
A
R
R
H
R
I
LRTTYPVGDDGVAQ--------P
T
--
V
HADLRPGWT-QY
D
L
T
D
L
S
Q
R
A
Q
R
L
R
L
E
V
L
A
QREFCAPFELSR-DA
P
L
R
I
T
V
V
RTAAD
E
H
V
L
L
L
V
A
H
H
IAWDDG
S
W
R
V
F
F
T
D
L
T
Q
-----
A
Y
S
RADLGADLG-P-EHRPSAA--------SG----PDT--------
T
E
A
D
L
N
Y
W
R
A
I
MADPPE----PLELPGPAGTCVPTSWR
A
A
-------
R
A
T
L
RLPA
D
T
A
A
R
V
A
T
-
M
AKNTG
C
T
P
Y
M
V
L
L
A
A
F
G
A
L
V
H
R
YTHSDD
F
L
V
AA
P
V
LNR-GA---GTE
D
A
I
G
YFG
N
T
V
A
M
R
LRP
Q
S
A
M
S
F
R
E
L
L
T
A
T
R
D
IASG
A
F
A
H
QRI
N
L
D
R
V
V
R
ELNP----
D
R
R
H
G
A
E
R
M
T
R
V
SFGFREPDGGG---------FN--------------PPG------I---
E
C
E
R
Y
D
L
RSN-
I
T
QLP
L
G
F
M
V
E
F-DRA
G
V
L
V
E
A
-
E
H
L
V
E
I
L
-------
E
P
A
L
A
K
Q
M
L
R
H
F
G
V
L
L
DNALAAPDNTLSG
L
A
LM-DE
R
D
A
A
R
L
R
E
V
SRGERFD
T
P
V
-
K
T
L
V
D
L
V
NEQTTRTPD
A
T
A
V
V
Y-EGQ
H
F
T
Y
H
D
L
N
E
A
S
N
R
L
G
H
W
L
I
EQGIGSE
D
R
V
A
V
L
LDKSP
D
L
I
V
T
A
L
G
VVKSG
A
V
Y
V
PVDPSY
P
Q
D
R
L
D
F
I
L
ADCD-
A
K
L
V
L
--------
R
T
P
--------
V
R
-------
E
L--A------G---Y-------RS-----D----------------D---P---------T
D
-------
A
D
RIR-------P-L----R---P------DN
T
A
Y
L
I
YTSGTTGLPKGVAVPHR
P
V
A
E
Y
F
V
W
F
KGEY---DVD
D
T
D
R
L
L
Q
VASPSF
D
V
S
I
A
E
I
F
G
T
L
ACG
A
R
M
-VI-PRP---GG
L
T
D
I
G
Y
L
T
A
L
L
RDEG
I
T
A
M
H
F
--------
V
P
S
L
L
G
L
F
LS--LPG----
V
S
Q
W
R
--
T
---
L
QRVP--IGGE--PL
P
G
E
V
A
D
K
F
H
A
T
F
-
D
---
A
L
--
L
H
N
FYGP
T
E
T
V
I
NAS
R
F
K
V
---VG---P----QG
T
R
I
----
V
PIGRP-KIN
T
T
M
H
L
LD-DSLQPVP-TG
V
I
G
E
I
Y
IG
G
T
H
V
A
Y
G
YHRRAGL
T
A
E
R
F--VADPF-N-PGS-RMYRSGDLARRNADG
D
I
E
F
VGRAD
E
Q
V
K
I
R
G
F
R
I
E
LG
D
V
A
A
A
I
A
VDPTV
G
Q
A
V
---
V
V
V
S
D
------
L
-
P
R
L
G
---
K
S
L
V
G
-
Y
VTPAAGGDGPADVGV
D
L
D
R
I
R
A
R
V
A
A
A
L
P
E
Y
M
L
P
A
A
Y
V
V
L
-DEIPITAHGKIDRAALPEP---QIA-SD--TEFRAP
Q
T
A
T
E
R
R
L
A
Q
L
F
G
E
L
LGRDRVGADDSFFDLGG
H
S
L
L
A
T
K
L
V
A
A
V
R
N
A
-FGV
D
V
G
V
R
E
I
F
E
F
A
T
V
T
A
L
AGHIDTLDSDSARPRLTRVDHDG
P
V
RL
S
S
S
Q
M
R
S
W
F
N
Y
RFDGPNAVNNIP
F
A
AALHGPCDT-
N
A
F
A
A
A
I
T
D
V
V
A
R
H
E
I
L
R
T
V
Y
R
E
IG-GV
P
H
Q
IIQPPAEV
P
V
R
--
C
AAGS------D
A
A
W
L
R
A
ELNNER
G
Y
V
F
DLETDW
P
I
R
A
A
L
LST
P
-
E
Q
T
V
L
S
L
V
V
H
H
IAGDHWS
A
G
V
L
F
T
D
L
L
T
A
Y
R
ARSTGQRPSWAPLP
V
Q
YA
D
Y
S
V
W
Q
S
A
LLDDGAGIVGPQ
R
D
Y
W
I
R
Q
L
GGLAGETGLRPDFPR
P
A
LLSGAG
D
A
V
E
F
R
L
G
A
A
I
R
D
K
L
A
A
V
S
R
DL
G
V
T
E
F
M
L
L
Q
A
A
V
A
V
V
L
HKAGGGVDVPIGAPVAGRSE--A
N
L
D
Q
L
I
G
F
F
I
N
I
V
V
L
RNDLRGN
P
T
L
R
E
V
L
Q
R
T
R
Q
M
A
L
A
A
YAHQDL
P
F
D
Q
V
V
E
A
VNPQRSLSRN
P
L
F
D
I
V
V
H
V
R
E
QMPQDHVIDT---------GPDGD
T
T
L
R
V
LEPTFDAAQAD
L
S
V
N
F
F
-
A
CGDEYR
G
H
V
I
Y
R
T
E
L
Y
E
R
A
T
A
Q
R
F
A
D
W
L
V
R
V
V
E
A
F
ADRPDQ
P
L
R
E
V
E
M
V
S
A
Q
A
R
R
R
I
L------------------------------------------------------D-----------------------------------------------------------------RS---------N-----------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------G----------------------------------------------------------------------------------------------------------------------------------------------------------------AG
T
A
R
V
Y
L
LDDALKPVPV
G
V
VGDVYYGG
G
P
A
V
GARLARPSE
T
A
T
RFVADPFAAQPG
S
R
LYRNGERGVWKADG
Q
L
E
L
L
A
E
I
E
RLPTAQA---------------------------------------------------------------------------------------------A-------------------------------------------------------PVPAEPAD
T
E
T
E
R
A
L
A
A
I
L
A
D
V
L
E
VGEVGRY
D
D
F
F
NLGG
D
S
I
L
A
T
Q
V
A
A
RARD-GGI
P
L
T
A
R
M
V
FEH
P
V
L
C
E
L
A
A
AVDAKPHVEAEPDDKHHAPMSTSGL
S
P
D
E
L
S
A
L
TASWDQWP
52
HHSearch
91.92
27%
-90
- C1 -
2VSQ
2
SRFAC_BACSU
A:
[22-1060]
M
L
F
H
A
I
L
N
P
G
Q
S
F
Y
L
E
Q
I
T
M
K
V
K
G
S
L
N
I
-
K
-
C
L
E
E
S
M
N
V
I
M
D
R
Y
D
V
F
R
T
V
F
I
H
E
K
V
K
R
P
V
--------
Q
V
--
V
L
K
K
R
Q
F
H
I
E
-
E
I
D
L
T
H
L
T
G
S
E
Q
T
A
K
I
N
E
Y
K
E
Q
D
K
I
R
G
F
D
L
T
R
-
D
I
P
M
R
A
A
I
F
K
K
A
E
E
S
F
E
W
V
W
S
Y
H
H
I
I
L
D
G
W
C
F
G
I
V
V
Q
D
L
F
K
-----
V
Y
N
A
L
R
E
Q
K
P
Y
S
-
L
P
P
V
K
P
Y
K
D
Y
I
K
W
----
L
E
----
K
Q
D
--------
K
Q
A
S
L
R
Y
W
R
E
Y
L
E
G
F
E
G
----
Q
T
T
F
A
E
Q
R
K
K
Q
-
K
D
G
Y
E
P
K
-------
E
L
L
F
S
P
S
E
A
E
T
K
A
F
T
E
-
L
A
K
S
Q
H
T
T
L
S
T
A
L
Q
A
V
W
S
V
L
I
S
R
Y
Q
Q
S
G
D
L
A
F
G
T
V
V
S
G
R
-
P
A
EIK
G
V
E
H
M
V
G
L
F
I
N
V
V
P
R
R
V
K
L
S
E
G
I
T
F
N
G
L
L
K
R
L
Q
E
Q
S
L
Q
S
E
P
H
Q
Y
V
P
L
Y
D
I
Q
S
Q
A
D
Q
----------
P
K
L
I
D
H
I
I
V
F
E
N
Y
P
L
Q
D
---------
A
K
NEESS---------
E
N
G
------
F
---
D
M
V
D
V
-
H
V
F
E
-
K
S
N
Y
D
L
N
L
M
A
S
--
P
G
D
E
M
L
I
K
L
-
A
Y
N
E
N
V
F
-------
D
E
A
F
I
L
R
L
K
S
Q
L
L
T
A
I
Q
Q
L
I
Q
N
P
D
Q
P
V
S
T
I
N
L
V
-
D
D
R
E
R
E
F
L
L
T
G
L
N
P
P
A
Q
A
H
E
T
-
K
P
L
T
Y
W
F
K
E
A
V
N
A
N
P
D
A
P
A
L
T
Y
-
S
G
Q
T
L
S
Y
R
E
L
D
E
E
A
N
R
I
A
R
R
L
Q
K
H
G
A
G
K
G
S
V
V
A
L
Y
T
K
R
S
L
E
L
V
I
G
I
L
G
V
L
K
A
G
A
A
Y
L
P
V
D
P
K
L
P
E
D
R
I
S
Y
M
L
A
D
S
A
-
A
A
C
L
L
--------
T
H
Q
--------
E
M
-------
K
E
QA
A
------
E
---
L
PYT
G
T
T
L
F
I
-----
D
----------------
D
---
Q
TRFEE----
Q
A
-------
S
D
P
A
T
-------
A
-
I
----
D
---
P
------
N
D
P
A
Y
I
M
Y
T
S
G
T
T
G
K
P
K
G
N
I
T
T
H
A
N
I
Q
G
L
V
K
H
V
-
D
Y
M
---
A
F
S
D
Q
D
T
F
L
S
V
S
N
Y
A
F
D
A
F
T
F
D
F
Y
A
S
M
L
N
A
A
R
L
-
I
I
-
A
D
E
---
H
T
L
L
D
T
E
R
L
T
D
L
I
L
Q
E
N
V
N
V
M
F
A
--------
T
T
A
L
F
N
L
L
T
D
--
A
G
-----
E
D
W
M
K
--
G
---
L
R
C
I
L
--
F
G
G
E
--
R
A
S
V
P
H
V
R
K
A
L
R
I
M
G
P
---
G
K
--
L
I
N
C
Y
G
P
T
E
G
T
V
F
A
T
A
H
V
V
---
H
D
L--
P
----
D
S
I
S
S
----
L
P
I
G
K
P
-
I
S
N
A
S
V
Y
I
L
N
-
E
Q
S
Q
L
Q
P
-
F
G
A
V
G
E
L
C
I
S
G
M
G
V
S
K
G
Y
V
N
R
A
D
L
T
K
E
K
F
--
I
E
N
P
F
-
K
-
P
G
E
-
T
L
Y
R
T
G
D
L
A
R
W
L
P
D
G
T
I
E
Y
A
G
R
I
D
D
Q
V
K
I
R
G
H
R
I
E
L
E
E
I
E
K
Q
L
Q
E
Y
P
G
V
K
D
A
V
---
V
V
A
D
R
------
H
-
E
S
G
D
---
A
S
I
N
A
-
Y
L
V
N
R
T
Q
--------
L
S
A
E
D
V
K
A
H
L
K
K
Q
L
P
A
Y
M
V
P
Q
T
F
T
F
L
-
D
E
L
P
L
T
T
N
G
K
V
N
K
R
L
L
P
K
P
---
D
Q
D
-
Q
L
A
-
E
E
W
I
G
P
R
N
E
M
E
E
T
I
A
Q
I
W
S
E
V
L
G
R
K
Q
I
G
I
H
D
D
F
F
A
L
G
G
H
A
L
K
A
M
T
A
A
S
R
I
K
K
E
-
L
G
I
D
L
P
V
K
L
L
F
E
A
P
T
I
A
G
I
S
A
Y
L
K
N
G
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
91.78
27%
-87
- C1 -
2VSQ
2
SRFAC_BACSU
A:
[22-1062]
M
L
F
H
A
I
L
N
P
G
Q
S
F
Y
L
E
Q
I
T
M
K
V
K
G
S
L
N
I
-
K
-
C
L
E
E
S
M
N
V
I
M
D
R
Y
D
V
F
R
T
V
F
I
--
H
E
K
V
K
R
--------
P
V
Q
V
V
L
K
K
R
Q
F
H
I
E
-
E
I
D
L
T
H
L
T
G
S
E
Q
T
A
K
I
N
E
Y
K
E
Q
D
K
I
R
G
F
D
L
T
R
-
D
I
P
M
R
A
A
I
F
K
K
A
E
E
S
F
E
W
V
W
S
Y
H
H
I
I
L
D
G
W
C
F
G
I
V
V
Q
D
L
F
K
-----
V
Y
N
A
L
---
R
E
Q
K
-
P
-
Y
S
L
P
P
V
K
--------
P
Y
----
K
D
Y
I
K
W
L
E
K
QD
K
Q
A
S
L
R
Y
W
R
E
Y
-------------
L
E
G
F
E
G
Q
T
T
F
A
E
Q
R
K
K
Q
K
D
G
Y
E
P
K
E
L
L
F
S
P
S
E
A
E
T
K
A
F
T
E
L
A
K
S
Q
H
T
T
L
S
T
A
L
Q
A
V
W
S
V
L
I
S
R
Y
Q
Q
S
G
D
L
A
F
G
T
V
V
S
G
R
-
P
A
EIK
G
V
E
H
M
V
G
L
F
I
N
V
V
P
R
R
V
K
L
S
E
G
I
T
F
N
G
L
L
K
R
L
Q
E
Q
S
L
Q
S
E
P
H
Q
Y
V
P
L
Y
D
I
Q
S
Q
A
D
Q
PKLI
D
H
I
I
V
F
E
N
Y
P
L
Q
D
A
K
N
E
E
S
S
E
N
G
---------
F
D
--------------
M
V
D
------
V
H
V
F
E
K
S
N
Y
D
L
--
N
-
L
M
A
S
P
G
D
E
M
---------
L
I
K
L
-
A
Y
N
E
N
V
F
-------
D
E
A
F
I
L
R
L
K
S
Q
L
L
T
A
I
Q
Q
L
I
Q
N
P
D
Q
P
V
S
T
I
N
L
V
-
D
D
R
E
R
E
F
L
L
T
G
L
N
P
P
A
Q
A
H
E
T
-
K
P
L
T
Y
W
F
K
E
A
V
N
A
N
P
D
A
P
A
L
T
Y
-
S
G
Q
T
L
S
Y
R
E
L
D
E
E
A
N
R
I
A
R
R
L
Q
K
H
G
A
G
K
G
S
V
V
A
L
Y
T
K
R
S
L
E
L
V
I
G
I
L
G
V
L
K
A
G
A
A
Y
L
P
V
D
P
K
L
P
E
D
R
I
S
Y
M
L
A
D
S
A
-
A
A
C
L
L
T
-------
H
Q
E
--------
M
K
-------
E
Q
--
A
------
A
ELP
Y
-------
T
G
T
T
L
F
I
D
----------------
D
---
Q
---------
T
R
FEEQA--
S
D
P
A
T
-------
A
-
I
----
D
---
P
------
N
D
P
A
Y
I
M
Y
T
S
G
T
T
G
K
P
K
G
N
I
T
T
H
A
N
I
-
Q
G
L
V
K
H
V
D
Y
M
---
A
F
S
D
Q
D
T
F
L
S
V
S
N
Y
A
F
D
A
F
T
F
D
F
Y
A
S
M
L
N
A
A
R
L
-
I
I
-
A
D
E
---
H
T
L
L
D
T
E
R
L
T
D
L
I
L
Q
E
N
V
N
V
M
F
A
--------
T
T
A
L
F
N
L
-
L
T
--
D
A
G
----
E
D
W
M
K
--
G
---
L
R
C
I
L
--
F
G
G
E
RA
S
V
P
-
H
V
R
K
A
L
R
I
M
G
-
P
---
G
K
--
L
I
N
C
Y
G
P
T
E
G
T
V
F
A
T
A
H
V
V
---
H
D
L--
P
----
D
S
I
S
S
----
L
P
I
G
K
P
-
I
S
N
A
S
V
Y
I
L
N
-
E
Q
S
Q
L
Q
P
-
F
G
A
V
G
E
L
C
I
S
G
M
G
V
S
K
G
Y
V
N
R
A
D
L
T
K
E
K
F
--
I
E
N
P
F
-
K
-
P
G
E
-
T
L
Y
R
T
G
D
L
A
R
W
L
P
D
G
T
I
E
Y
A
G
R
I
D
D
Q
V
K
I
R
G
H
R
I
E
L
E
E
I
E
K
Q
L
Q
E
Y
P
G
V
K
D
A
V
---
V
V
A
D
R
------
H
-
E
S
G
D
---
A
S
I
N
A
-
Y
L
V
N
R
--------
T
Q
L
S
A
E
D
V
K
A
H
L
K
K
Q
L
P
A
Y
M
V
P
Q
T
F
T
F
L
-
D
E
L
P
L
T
T
N
G
K
V
N
K
R
L
L
P
K
P
DQD
Q
L
A
-
E
----
E
W
I
G
P
R
N
E
M
E
E
T
I
A
Q
I
W
S
E
V
L
G
R
K
Q
I
G
I
H
D
D
F
F
A
L
G
G
H
A
L
K
A
M
T
A
A
S
R
I
K
K
E
-
L
G
I
D
L
P
V
K
L
L
F
E
A
P
T
I
A
G
I
S
A
Y
L
K
N
G
G
S
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
HHSearch
91.29
28%
-87
- C1 -
4ZXJ
1
ENTF_ECOLI
A:
[11-1041]
I
W
M
A
E
K
L
S
E
L
P
S
A
W
S
V
A
H
Y
V
E
L
T
G
E
V
D
S
-
P
-
L
L
A
R
A
V
V
A
G
L
A
Q
A
D
T
L
R
M
R
F
T
E
D
N
-
G
E
V
W
--------
Q
W
--
V
D
D
A
L
T
F
E
L
P
E
I
I
D
L
R
T
N
I
D
--
P
H
G
T
A
Q
A
L
M
Q
A
D
L
Q
Q
D
L
R
V
D
S
G
K
P
L
V
F
H
Q
L
I
Q
V
A
D
N
R
W
Y
W
Y
Q
R
Y
H
H
L
L
V
D
G
F
S
F
P
A
I
T
R
Q
I
A
N
-----
I
Y
C
T
W
L
R
G
E
P
T
P
A
S
-
P
F
T
P
F
A
D
V
V
E
E
Y
Q
Q
Y
R
E
----
S
E
A
--------
W
Q
R
D
A
A
F
W
A
E
Q
R
R
Q
L
P
P
----
P
A
S
L
S
P
A
P
L
P
G
R
S
A
S
A
D
I
L
-------
R
L
K
L
E
F
T
D
G
--
E
F
R
Q
L
-
A
T
Q
L
S
G
V
Q
R
T
D
L
A
L
A
L
A
A
L
W
L
G
R
L
C
N
R
M
D
Y
A
A
G
F
I
F
M
R
R
-
L
G
S--
A
A
L
T
A
T
G
P
V
L
N
V
L
P
L
G
I
H
I
A
A
Q
E
T
L
P
E
L
A
T
R
L
A
A
Q
L
K
K
M
R
R
H
Q
R
Y
D
A
E
Q
I
V
R
D
S
G
R
----
A
--
A
G
D
E
P
L
F
G
P
V
L
N
I
K
V
F
D
Y
Q
L
----------
D
--------------
I
P
D
------
V
---
Q
A
Q
T
H
T
L
-
A
T
-
G
P
V
N
D
L
E
L
A
L
F
P
D
V
H
G
D
L
S
I
E
I
-
L
A
N
K
Q
R
Y
-------
D
E
P
T
L
I
Q
H
A
E
R
L
K
M
L
I
A
Q
F
A
A
D
P
A
L
L
C
G
D
V
D
I
M
-
L
P
G
E
Y
A
Q
L
A
-
Q
L
N
A
T
Q
V
E
I
P
E
-
T
T
L
S
A
L
V
A
E
Q
A
A
K
T
P
D
A
P
A
L
A
D
-
A
R
Y
L
F
S
Y
R
E
M
R
E
Q
V
V
A
L
A
N
L
L
R
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R
G
V
K
P
G
D
S
V
A
V
A
L
P
R
S
V
F
L
T
L
A
L
H
A
I
V
E
A
G
A
A
W
L
P
L
D
T
G
Y
P
D
D
R
L
K
M
M
L
E
D
A
R
-
P
S
L
L
I
--------
T
T
D
--------
D
Q
-------
L
P
RF
S
------
D
---
V
PN
L
T
S
L
-
C
Y
-----
N
----------------
A
PLT
P
---------
Q
G
-------
S
A
P
L
Q
-------
L
-
S
----
Q
---
P
------
H
H
T
A
Y
I
I
F
T
S
G
S
T
G
R
P
K
G
V
M
V
G
Q
T
A
I
V
N
R
L
L
W
M
Q
N
H
Y
---
P
L
T
G
E
D
V
V
A
Q
K
T
P
C
S
F
D
V
S
V
W
E
F
F
W
P
F
I
A
G
A
K
L
-
V
M
-
A
E
P
---
E
A
H
R
D
P
L
A
M
Q
Q
F
F
A
E
Y
G
V
T
T
T
H
F
--------
V
P
S
M
L
A
A
F
V
A
--
S
L
T
P
Q
T
A
R
Q
S
C
A
--
T
---
L
K
Q
V
F
--
C
S
G
E
--
A
L
P
A
D
L
C
R
E
W
Q
Q
L
T
-
G
---
A
P
--
L
H
N
L
Y
G
P
T
E
A
A
V
D
V
S
W
Y
P
A
---
F
G
---
E
E
L
A
Q
V
R
G
S
S
----
V
P
I
G
Y
P
-
V
W
N
T
G
L
R
I
L
D
-
A
M
M
H
P
V
P
-
P
G
V
A
G
D
L
Y
L
T
G
I
Q
L
A
Q
G
Y
L
G
R
P
D
L
T
A
S
R
F
--
I
A
D
P
F
-
A
-
P
G
E
-
R
M
Y
R
T
G
D
V
A
R
W
L
D
N
G
A
V
E
Y
L
G
R
S
D
D
Q
L
K
I
R
G
Q
R
I
E
L
G
E
I
D
R
V
M
Q
A
L
P
D
V
E
Q
A
V
---
T
H
A
C
V
INQAAA
T
-
G
G
D
A
---
R
Q
L
V
G
-
Y
L
V
S
Q
S
G
L
------
P
L
D
T
S
A
L
Q
A
Q
L
R
E
T
L
P
P
H
M
V
P
V
V
L
L
Q
L
-
P
Q
L
P
L
S
A
N
G
K
L
D
R
K
A
L
P
L
P
---
E
L
K
-
A
Q
--
A
P
G
R
A
P
K
A
G
S
E
T
I
I
A
A
A
F
S
S
L
L
G
C
D
V
Q
D
A
D
A
D
F
F
A
L
G
G
H
S
L
L
A
M
K
L
A
A
Q
L
S
R
Q
-
V
A
R
Q
V
T
P
G
Q
V
M
V
A
S
T
V
A
K
L
A
T
I
I
D
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
90.85
27%
-89
- C1 -
4ZXH
3
?
A:
[26-1040]
I
W
Y
I
Q
R
L
E
P
T
C
S
A
Y
N
M
V
V
A
F
D
V
K
V
N
Q
S
L
-
G
N
K
P
I
E
I
L
E
A
V
M
H
D
Y
P
L
L
R
V
S
M
P
A
N
D
Q
G
I
E
Q
L
I
W
DRVYP
N
I
--
I
F
S
D
A
R
-----
H
I
E
A
S
D
L
T
Q
---------
L
V
E
Q
D
T
K
Q
P
F
D
L
T
Q
-
P
P
L
W
R
I
H
C
Y
E
C
G
Q
N
H
Y
V
I
A
F
V
I
H
H
A
L
M
D
F
W
S
I
G
L
L
L
R
D
V
S
K
R
F
GLV
A
E
S
D
A
V
N
G
I
E
F
V
-
Q
-
Y
A
D
K
Q
Q
S
--------
S
V
----
I
D
D
--------
T
D
E
S
L
I
F
W
K
N
A
L
K
H
A
P
H
VHSI
P
L
D
Y
P
R
P
A
----
V
Q
Q
H
K
G
S
-------
S
L
V
F
R
V
S
E
S
V
S
S
G
L
V
N
-
L
A
K
D
Y
E
I
T
L
F
G
L
V
L
S
G
F
Y
V
L
L
H
K
L
S
N
E
N
N
L
V
I
A
T
P
V
A
G
R
L
E
R
---
S
L
R
N
A
L
G
Q
F
V
N
T
I
A
I
H
M
D
I
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A
D
Q
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L
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Q
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T
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Q
V
Q
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Q
L
R
Q
S
L
K
H
Q
K
I
A
F
S
R
V
V
E
A
V
S
P
----
K
R
D
G
S
I
N
P
L
A
Q
I
G
M
-
F
W
E
R
L
G
G
M
DEFKELLLP
I
Q
--------------
T
P
A
T
L
V
G
QD
L
---
T
L
G
S
F
P
V
R
Q
Q
-
E
G
Q
L
D
I
T
L
E
M
G
G
-
E
Y
Q
G
E
L
V
G
V
L
K
Y
N
T
D
L
F
-------
S
A
Q
S
A
E
N
M
V
Q
L
L
Q
A
V
L
S
E
M
V
A
H
P
E
R
K
I
V
E
L
D
I
A
P
D
Y
K
D
G
I
Q
F
-
E
A
L
R
G
K
A
T
D
Y
A
Q
-
H
D
L
F
A
M
I
L
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Q
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R
G
D
N
H
A
L
T
S
---
H
T
V
S
Y
R
E
L
G
Q
H
I
A
G
I
A
E
Y
L
R
A
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G
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M
L
D
R
T
A
L
L
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A
A
I
L
G
I
W
A
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A
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Y
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L
D
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N
F
P
T
E
R
L
Q
N
I
I
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D
A
E
-
P
K
V
I
L
---------
T
Q
--------
T
E
-------
L
M
--
D
------
G
---
L
-------
N
V
-----
S
----------------
V
---
P
R
L
D
INQ
A
G
V
V
A
-------
L
E
Q
V
R
-------
E
T
L
----
A
---
F
------
G
D
I
A
Y
V
M
Y
T
S
----
K
P
K
G
V
R
I
G
H
P
S
I
I
N
F
L
L
S
M
N
D
R
L
---
Q
V
T
T
E
T
Q
L
L
A
I
T
T
Y
A
F
D
I
S
I
L
E
L
L
I
P
L
M
Y
G
G
V
V
H
V
C
-
P
R
E
V
S
Q
D
G
I
Q
L
V
D
Y
L
N
A
----
K
S
I
N
V
L
Q
A
--------
T
P
A
T
W
K
M
L
L
D
----------
S
E
W
S
--
G
---
N
A
G
L
T
A
L
C
G
G
E
--
A
L
D
T
I
L
A
E
K
L
L
G
K
V
-
G
---
C
L
--
W
-
N
V
Y
G
P
T
E
T
T
V
W
S
S
A
A
R
I
---
T
D
----------
A
K
Y
----
I
D
L
G
E
P
-
L
A
N
T
Q
L
Y
V
L
D
-
E
Q
Q
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-
P
G
V
M
G
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L
W
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G
D
G
L
A
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D
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L
T
D
A
Q
F
--
R
T
L
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L
-
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N
A
G
R
L
Y
R
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V
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L
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G
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V
K
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R
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L
G
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I
E
N
V
L
K
Q
I
D
G
I
T
D
A
V
---
V
L
V
K
T
------
T
-
G
D
N
D
---
Q
K
L
V
A
-
Y
V
T
G
Q
E
---------
L
D
I
A
G
L
K
K
N
L
Q
I
H
L
P
A
Y
M
V
P
S
A
F
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R
L
-
D
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F
P
M
T
A
N
K
K
L
D
R
K
A
F
P
E
P
---
I
F
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-
Q
S
--
N
D
Y
V
A
P
R
D
P
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I
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L
C
T
T
F
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V
K
R
V
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I
H
D
D
F
F
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L
G
G
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L
L
A
V
K
L
V
N
H
L
K
K
A
-
F
G
T
E
L
S
V
A
L
L
A
Q
Y
S
T
V
E
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
90.79
27%
-90
- C1 -
4ZXI
5
?
A:
[26-1040]
I
W
Y
I
Q
R
L
E
P
T
C
S
A
Y
N
M
V
V
A
F
D
V
K
V
N
Q
S
L
-
G
N
K
P
I
E
I
L
E
A
V
M
H
D
Y
P
L
L
R
V
S
M
P
A
N
D
Q
G
I
E
Q
L
I
W
DRVYP
N
I
--
I
F
S
D
A
R
-----
H
I
E
A
S
D
L
T
Q
---------
L
V
E
Q
D
T
K
Q
P
F
D
L
T
Q
-
P
P
L
W
R
I
H
C
Y
E
C
G
Q
N
H
Y
V
I
A
F
V
I
H
H
A
L
M
D
F
W
S
I
G
L
L
L
R
D
V
S
K
R
F
GLV
A
E
S
D
A
V
N
G
I
E
F
V
-
Q
-
Y
A
D
K
Q
Q
S
--------
S
V
----
I
D
D
--------
T
D
E
S
L
I
F
W
K
N
A
L
K
H
A
P
H
VHSI
P
L
D
Y
P
R
P
A
----
V
Q
Q
H
K
G
S
-------
S
L
V
F
R
V
S
E
S
V
S
S
G
L
V
N
-
L
A
K
D
Y
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I
T
L
F
G
L
V
L
S
G
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L
L
H
K
L
S
N
E
N
N
L
V
I
A
T
P
V
A
G
R
L
E
R
---
S
L
R
N
A
L
G
Q
F
V
N
T
I
A
I
H
M
D
I
D
A
D
Q
T
L
R
Q
F
T
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Q
L
R
Q
S
L
K
H
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A
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S
R
V
V
E
A
V
S
P
----
K
R
D
G
S
I
N
P
L
A
Q
I
G
M
-
F
W
E
R
L
G
G
M
DEFKELLLP
I
Q
--------------
T
P
A
T
L
V
G
QD
L
---
T
L
G
S
F
P
V
R
Q
Q
-
E
G
Q
L
D
I
T
L
E
M
G
G
-
E
Y
Q
G
E
L
V
G
V
L
K
Y
N
T
D
L
F
-------
S
A
Q
S
A
E
N
M
V
Q
L
L
Q
A
V
L
S
E
M
V
A
H
P
E
R
K
I
V
E
L
D
I
A
P
D
Y
K
D
G
I
Q
F
-
E
A
L
R
G
K
A
T
D
Y
A
Q
-
H
D
L
F
A
M
I
L
K
Q
I
D
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R
G
D
N
H
A
L
T
S
---
H
T
V
S
Y
R
E
L
G
Q
H
I
A
G
I
A
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Y
L
R
A
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G
I
T
Q
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M
L
D
R
T
A
L
L
P
A
A
I
L
G
I
W
A
A
G
A
A
Y
V
P
L
D
P
N
F
P
T
E
R
L
Q
N
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I
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D
A
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-
P
K
V
I
L
---------
T
Q
--------
T
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-------
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M
--
D
------
G
---
L
-------
N
V
-----
S
----------------
V
---
P
R
L
DINQAGV
V
A
-------
L
E
Q
V
R
-------
E
T
L
----
A
---
F
------
G
D
I
A
Y
V
M
Y
T
S
----
K
P
K
G
V
R
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P
S
I
I
N
F
L
L
S
M
N
D
R
L
---
Q
V
T
T
E
T
Q
L
L
A
I
T
T
Y
A
F
D
I
S
I
L
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L
L
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P
L
M
Y
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G
V
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R
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D
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Y
L
N
A
----
K
S
I
N
V
L
Q
A
--------
T
P
A
T
W
K
M
L
L
D
----------
S
E
W
S
--
G
---
N
A
G
L
T
A
L
C
G
G
E
--
A
L
D
T
I
L
A
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K
L
L
G
K
V
-
G
---
C
L
--
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-
N
V
Y
G
P
T
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T
T
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W
S
S
A
A
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I
---
T
D
----------
A
K
Y
----
I
D
L
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-
L
A
N
T
Q
L
Y
V
L
D
-
E
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Q
R
L
V
P
-
P
G
V
M
G
E
L
W
I
G
G
D
G
L
A
V
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Y
W
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E
L
T
D
A
Q
F
--
R
T
L
P
S
-
L
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N
A
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R
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C
L
R
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R
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F
Q
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E
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N
V
L
K
Q
I
D
G
I
T
D
A
V
---
V
L
V
K
T
------
T
-
G
D
N
D
---
Q
K
L
V
A
-
Y
V
T
G
Q
E
---------
L
D
I
A
G
L
K
K
N
L
Q
I
H
L
P
A
Y
M
V
P
S
A
F
I
R
L
-
D
E
F
P
M
T
A
N
K
K
L
D
R
K
A
F
P
E
P
---
I
F
E
-
Q
S
--
N
D
Y
V
A
P
R
D
P
I
E
I
E
L
C
T
T
F
E
Q
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V
K
R
V
G
I
H
D
D
F
F
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L
G
G
H
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L
L
A
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K
L
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N
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L
K
K
A
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F
G
T
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L
S
V
A
L
L
A
Q
Y
S
T
V
E
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
HHSearch
90.22
26%
-92
- C1 -
4ZXH
3
?
A:
[26-1047]
I
W
Y
I
Q
R
L
E
P
T
C
S
A
Y
N
M
V
V
A
F
D
V
K
V
N
Q
S
L
G
N
-
K
P
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L
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A
V
M
H
D
Y
P
L
L
R
V
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M
P
A
N
D
-
Q
G
I
E
--------
Q
L
--
I
W
D
R
V
Y
P
N
I
I
-
F
S
D
A
R
H
I
E
----
A
S
D
L
T
Q
L
V
E
Q
D
T
K
Q
P
F
D
L
T
Q
-
P
P
L
W
R
I
H
C
Y
E
C
G
Q
N
H
Y
V
I
A
F
V
I
H
H
A
L
M
D
F
W
S
I
G
L
L
L
R
D
V
S
K
-----
R
F
G
L
V
A
E
S
D
A
V
N
G
I
-
E
F
V
Q
Y
A
D
--------
K
Q
Q
S
SV
I
D
D
--------
T
D
E
S
L
I
F
W
K
N
A
L
K
H
A
P
H
----
V
H
S
I
P
L
D
Y
P
R
P
A
V
Q
Q
H
K
G
S
-------
S
L
V
F
R
V
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S
G
L
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N
-
L
A
K
D
Y
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L
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F
Y
V
L
L
H
K
L
S
N
E
N
N
L
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A
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R
-
L
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R--
S
L
R
N
A
L
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N
T
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A
I
H
M
D
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A
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H
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F
W
E
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L
G
G
M
D
---------
E
F
KELLLPIQTP
A
T
L
V
G
Q
D
------
L
---
T
L
G
S
F
P
V
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Q
Q
-
E
G
Q
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D
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T
D
L
F
-------
S
A
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Q
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L
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A
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L
S
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A
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P
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K
I
V
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D
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A
-
P
D
Y
K
D
G
I
Q
F
E
A
L
R
G
K
A
T
D
Y
A
Q
-
H
D
L
F
A
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I
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Q
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D
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G
D
N
H
A
L
T
S
---
H
T
V
S
Y
R
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H
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A
G
I
A
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L
M
L
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A
L
L
P
A
A
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L
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A
A
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A
A
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V
P
L
D
P
N
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A
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K
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--------
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Q
T
--------
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M
D
--
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LNVS
V
P
R
---
L
-------
D
I
-----
N
----------------
Q
A
G
V
V
---------
A
L
-------
E
Q
V
R
E
-------
T
-
L
----
A
---
F
------
G
D
I
A
Y
V
M
Y
T
S
----
K
P
K
G
V
R
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G
H
P
S
I
I
N
F
L
L
S
M
N
D
R
L
---
Q
V
T
T
E
T
Q
L
L
A
I
T
T
Y
A
F
D
I
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I
L
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L
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Y
G
G
V
V
-
H
V
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C
P
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---
E
V
S
Q
D
G
I
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L
V
D
Y
L
N
A
K
S
I
N
V
L
Q
A
--------
T
P
A
T
W
K
M
L
L
D
--
S
E
------
W
S
G
N
--
A
---
G
L
T
A
L
--
C
G
G
E
--
A
L
D
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L
L
G
K
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-----
G
C
--
L
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T
T
V
W
S
S
A
A
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I
---
T
----------
D
A
K
Y
----
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D
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L
A
N
T
Q
L
Y
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L
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L
V
P
-
P
G
V
M
G
E
L
W
I
G
G
D
G
L
A
V
D
Y
W
Q
R
P
E
L
T
D
A
Q
F
--
R
T
L
P
S
-
L
P
N
A
G
-
R
L
Y
R
T
G
D
K
V
C
L
R
T
D
G
R
L
T
H
H
G
R
L
D
F
Q
V
K
I
R
G
F
R
I
E
L
G
E
I
E
N
V
L
K
Q
I
D
G
I
T
D
A
V
---
V
L
V
K
T
------
T
-
G
D
N
D
---
Q
K
L
V
A
-
Y
V
T
G
Q
E
---------
L
D
I
A
G
L
K
K
N
L
Q
I
H
L
P
A
Y
M
V
P
S
A
F
I
R
L
-
D
E
F
P
M
T
A
N
K
K
L
D
R
K
A
F
P
E
P
---
I
F
E
-
Q
S
--
N
D
Y
V
A
P
R
D
P
I
E
I
E
L
C
T
T
F
E
Q
I
L
S
V
K
R
V
G
I
H
D
D
F
F
E
L
G
G
H
S
L
L
A
V
K
L
V
N
H
L
K
K
A
-
F
G
T
E
L
S
V
A
L
L
A
Q
Y
S
T
V
E
R
L
G
E
I
I
R
E
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
79.43
32%
-78
- C1 -
4ZXJ
1
ENTF_ECOLI
A:
[257-1042]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
R
L
C
N
R
M
D
Y
A
A
G
F
I
F
---
M
R
R
L
-
G
S
---
A
A
L
T
A
T
G
P
V
L
N
V
L
P
L
G
I
H
I
A
A
Q
E
T
L
P
E
L
A
T
R
L
A
A
Q
L
K
K
M
R
R
H
Q
R
Y
D
A
E
Q
I
V
R
--
D
S
----
G
R
A
A
G
D
E
P
L
F
G
P
V
L
N
I
K
V
F
D
Y
Q
----------
L
D
--------------
I
P
D
------
V
---
Q
A
Q
T
H
T
L
A
T
G
P
V
N
D
L
E
L
A
L
F
P
D
--------
V
H
G
-
D
L
S
I
E
I
L
A
N
KQRYD
E
P
T
L
I
Q
H
A
E
R
-
L
K
M
L
I
A
Q
F
A
A
D
P
A
L
L
C
G
D
V
D
I
M
-
L
P
G
E
Y
A
Q
L
A
Q
L
N
-
A
T
Q
V
E
I
P
E
-
T
T
L
S
A
L
V
A
E
Q
A
A
K
T
P
D
A
P
A
L
A
D
-
A
R
Y
L
F
S
Y
R
E
M
R
E
Q
V
V
A
L
A
N
L
L
R
E
R
G
V
K
P
G
D
S
V
A
V
A
L
P
R
S
V
F
L
T
L
A
L
H
A
I
V
E
A
G
A
A
W
L
P
L
D
T
G
Y
P
D
D
R
L
K
M
M
L
E
D
A
R
-
P
S
L
L
I
--------
T
T
D
DQLPRFSD
V
P
-------
N
L
--
T
------
S
---
L
-------
C
Y
-----
N
----------------
A
---
P
---------
L
T
-------
P
Q
G
S
A
-------
P
-
L
----
Q
LSQ
P
------
H
H
T
A
Y
I
I
F
T
S
G
S
T
G
R
P
K
G
V
M
V
G
Q
T
A
I
V
N
R
L
L
W
M
Q
N
H
Y
---
P
L
T
G
E
D
V
V
A
Q
K
T
P
C
S
F
D
V
S
V
W
E
F
F
W
P
F
I
A
G
A
K
L
-
V
M
-
A
E
P
---
E
A
H
R
D
P
L
A
M
Q
Q
F
F
A
E
Y
G
V
T
T
T
H
F
--------
V
P
S
M
L
A
A
F
V
A
S
L
T
P
Q
----
T
A
R
Q
S
CA
T
---
L
K
Q
V
F
--
C
S
G
E
--
A
L
P
A
D
L
C
R
E
W
Q
Q
L
T
-
G
---
A
P
--
L
H
N
L
Y
G
P
T
E
A
A
V
D
V
S
W
Y
P
A
---
F
G
---
E
----
E
L
A
Q
V
RGSS
V
P
I
G
Y
P
-
V
W
N
T
G
L
R
I
L
D
-
A
M
M
H
P
V
P
-
P
G
V
A
G
D
L
Y
L
T
G
I
Q
L
A
Q
G
Y
L
G
R
P
D
L
T
A
S
R
F
--
I
A
D
P
F
-
A
-
P
G
E
-
R
M
Y
R
T
G
D
V
A
R
W
L
D
N
G
A
V
E
Y
L
G
R
S
D
D
Q
L
K
I
R
G
Q
R
I
E
L
G
E
I
D
R
V
M
Q
A
L
P
D
V
E
Q
A
V
T
H
A
C
V
I
N
Q
------
A
-
A
A
T
G
GDA
R
Q
L
V
G
-
Y
L
V
S
Q
S
G
------
L
P
L
D
T
S
A
L
Q
A
Q
L
R
E
T
L
P
P
H
M
V
P
V
V
L
L
Q
L
-
P
Q
L
P
L
S
A
N
G
K
L
D
R
K
A
L
P
L
P
---
E
L
K
-
A
Q
--
A
P
G
R
A
P
K
A
G
S
E
T
I
I
A
A
A
F
S
S
L
L
G
C
D
V
Q
D
A
D
A
D
F
F
A
L
G
G
H
S
L
L
A
M
K
L
A
A
Q
L
S
R
Q
-
V
A
R
Q
V
T
P
G
Q
V
M
V
A
S
T
V
A
K
L
A
T
I
I
D
A
-
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
HHSearch
71.96
36%
-82
- C1 -
5ES8
1
LGRA_BREPA
A:
[203-768]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
F
H
Q
L
F
E
Q
Q
V
E
M
T
P
D
H
V
A
V
V
D
-
R
G
Q
S
L
T
Y
K
Q
L
N
E
R
A
N
Q
L
A
H
H
L
R
G
K
G
V
K
P
D
D
Q
V
A
I
M
L
D
K
S
L
D
M
I
V
S
I
L
A
V
M
K
A
G
G
A
Y
V
P
I
D
P
D
Y
P
G
E
R
I
A
Y
M
L
A
D
S
S
-
A
A
I
L
L
--------
T
N
A
--------
L
H
-------
E
E
--
K
ANGA
C
D
I
---
I
-------
D
V
-----
H
----------------
D
---
P
DSYSE----
N
T
-------
N
N
L
P
H
-------
V
-
N
----
R
---
P
------
D
D
L
V
Y
V
M
Y
T
S
G
S
T
G
L
A
K
G
V
M
I
E
H
H
N
L
V
N
F
C
E
W
Y
R
P
Y
F
---
G
V
T
P
A
D
K
A
L
V
Y
S
S
F
S
F
D
G
S
A
L
D
I
F
T
H
L
L
A
G
A
A
L
-
H
I
-
V
P
S
---
E
R
K
Y
D
L
D
A
L
N
D
Y
C
N
Q
E
G
I
T
I
S
Y
L
--------
P
T
G
A
A
E
Q
F
M
Q
--
M
--------
D
N
Q
--
S
---
F
R
V
V
I
--
T
G
G
D
--
V
L
K
K
I
-----
E
R
N
G
-
T
---
Y
K
--
L
Y
N
G
Y
G
P
T
E
C
T
I
M
V
T
M
F
E
V
---
D
K
---------
P
Y
A
N
----
I
P
I
G
K
P
-
I
D
R
T
R
I
L
I
L
D
-
E
A
L
A
L
Q
P
-
I
G
V
A
G
E
L
F
I
V
G
E
G
L
G
R
G
Y
L
N
R
P
E
L
T
A
E
K
F
--
I
V
H
P
Q
---
T
G
E
-
R
M
Y
R
T
G
D
R
A
R
F
L
P
D
G
N
I
E
F
L
G
R
L
D
N
L
V
K
I
R
G
Y
R
I
E
P
G
E
I
E
P
F
L
M
N
H
P
L
I
E
L
T
T
---
V
L
A
K
E
------
Q
-
A
D
G
R
---
K
Y
L
V
G
-
Y
Y
V
A
P
E
E
--------
I
P
H
G
E
L
R
E
W
L
G
N
D
L
P
D
Y
M
I
P
T
Y
F
V
H
M
-
K
A
F
P
L
T
A
N
G
K
V
D
R
R
A
L
P
D
V
--------------
V
A
P
T
D
E
L
E
Q
Q
L
A
Q
V
W
S
H
V
L
G
I
P
Q
M
G
I
D
D
H
F
L
E
R
G
G
D
S
I
K
V
M
Q
L
I
H
Q
L
K
N
--
I
G
L
S
L
R
Y
D
Q
L
F
T
H
P
T
I
R
Q
L
K
R
L
L
T
E
Q
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
71.44
35%
-73
- C1 -
5ES8
1
LGRA_BREPA
B:
[193-760]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
P
K
R
G
E
K
---
P
I
D
K
T
F
H
Q
L
F
E
Q
Q
V
E
M
T
P
D
H
V
A
V
V
D
-
R
G
Q
S
L
T
Y
K
Q
L
N
E
R
A
N
Q
L
A
H
H
L
R
G
K
G
V
K
P
D
D
Q
V
A
I
M
L
D
K
S
L
D
M
I
V
S
I
L
A
V
M
K
A
G
G
A
Y
V
P
I
D
P
D
Y
P
G
E
R
I
A
Y
M
L
A
D
S
S
-
A
A
I
L
L
--------
T
N
A
--------
L
H
-------
E
E
--
K
------
A
---
N
-------
G
A
-----
C
----------------
D
---
I
---------
I
D
VHDPDSY
S
E
N
T
N
-------
N
-
L
PHVN
R
---
P
------
D
D
L
V
Y
V
M
Y
T
S
G
S
T
G
L
A
K
G
V
M
I
E
H
H
N
L
V
N
F
C
E
W
Y
R
P
Y
F
---
G
V
T
P
A
D
K
A
L
V
Y
S
S
F
S
F
D
G
S
A
L
D
I
F
T
H
L
L
A
G
A
A
L
-
H
I
-
V
P
S
---
E
R
K
Y
D
L
D
A
L
N
D
Y
C
N
Q
E
G
I
T
I
S
Y
L
--------
P
T
G
A
A
E
Q
F
M
Q
--
M
D
N
----
Q
S
----------
F
R
V
V
--
I
T
G
------
G
D
V
L
K
K
I
E
R
N
G
-
T
---
Y
K
--
L
Y
N
G
Y
G
P
T
E
C
T
I
M
V
T
M
F
E
V
---
D
K
---
P
----
Y
A
N
------
I
P
I
G
K
P
-
I
D
R
T
R
I
L
I
L
D
-
E
A
L
A
L
Q
P
-
I
G
V
A
G
E
L
F
I
V
G
E
G
L
G
R
G
Y
L
N
R
P
E
L
T
A
E
K
F
--
I
V
H
P
--
Q
-
T
G
E
-
R
M
Y
R
T
G
D
R
A
R
F
L
P
D
G
N
I
E
F
L
G
R
L
D
N
L
V
K
I
R
G
Y
R
I
E
P
G
E
I
E
P
F
L
M
N
H
P
L
I
E
L
T
T
---
V
L
A
K
E
------
Q
-
A
D
G
R
---
K
Y
L
V
G
Y
Y
V
A
P
E
E
I
P
H
G
---------
E
L
R
E
W
L
G
N
D
L
P
D
Y
M
I
P
T
Y
F
V
H
M
-
K
A
F
P
L
T
A
N
G
K
V
D
R
R
A
L
P
D
V
---
Q
A
D
-
A
E
LL-
D
Y
V
A
P
T
D
E
L
E
Q
Q
L
A
Q
V
W
S
H
V
L
G
I
P
Q
M
G
I
D
D
H
F
L
E
R
G
G
D
S
I
K
V
M
Q
L
I
H
Q
L
K
N
--
I
G
L
S
L
R
Y
D
Q
L
F
T
H
P
T
I
R
Q
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
70.98
35%
-73
- C1 -
5ES8
1
LGRA_BREPA
A:
[193-760]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
P
K
R
G
E
K
---
P
I
D
K
T
F
H
Q
L
F
E
Q
Q
V
E
M
T
P
D
H
V
A
V
V
D
-
R
G
Q
S
L
T
Y
K
Q
L
N
E
R
A
N
Q
L
A
H
H
L
R
G
K
G
V
K
P
D
D
Q
V
A
I
M
L
D
K
S
L
D
M
I
V
S
I
L
A
V
M
K
A
G
G
A
Y
V
P
I
D
P
D
Y
P
G
E
R
I
A
Y
M
L
A
D
S
S
-
A
A
I
L
L
--------
T
N
A
--------
L
H
-------
E
E
--
K
------
A
---
N
-------
G
A
-----
C
----------------
D
---
I
---------
I
D
VHDPDSY
S
E
N
T
N
-------
N
-
L
PHVN
R
---
P
------
D
D
L
V
Y
V
M
Y
T
S
G
S
T
G
L
A
K
G
V
M
I
E
H
H
N
L
V
N
F
C
E
W
Y
R
P
Y
F
---
G
V
T
P
A
D
K
A
L
V
Y
S
S
F
S
F
D
G
S
A
L
D
I
F
T
H
L
L
A
G
A
A
L
-
H
I
-
V
P
S
---
E
R
K
Y
D
L
D
A
L
N
D
Y
C
N
Q
E
G
I
T
I
S
Y
L
--------
P
T
G
A
A
E
Q
F
M
Q
--
M
D
N
----
Q
S
----------
F
R
V
V
--
I
T
G
------
G
D
V
L
K
K
I
E
R
N
G
-
T
---
Y
K
--
L
Y
N
G
Y
G
P
T
E
C
T
I
M
V
T
M
F
E
V
---
D
K
---
P
----
Y
A
N
------
I
P
I
G
K
P
-
I
D
R
T
R
I
L
I
L
D
-
E
A
L
A
L
Q
P
-
I
G
V
A
G
E
L
F
I
V
G
E
G
L
G
R
G
Y
L
N
R
P
E
L
T
A
E
K
F
--
I
V
H
P
--
Q
-
T
G
E
-
R
M
Y
R
T
G
D
R
A
R
F
L
P
D
G
N
I
E
F
L
G
R
L
D
N
L
V
K
I
R
G
Y
R
I
E
P
G
E
I
E
P
F
L
M
N
H
P
L
I
E
L
T
T
---
V
L
A
K
E
------
Q
-
A
D
G
R
---
K
Y
L
V
G
Y
Y
V
A
P
E
E
I
P
H
G
---------
E
L
R
E
W
L
G
N
D
L
P
D
Y
M
I
P
T
Y
F
V
H
M
-
K
A
F
P
L
T
A
N
G
K
V
D
R
R
A
L
P
D
V
--------------
V
A
P
T
D
E
L
E
Q
Q
L
A
Q
V
W
S
H
V
L
G
I
P
Q
M
G
I
D
D
H
F
L
E
R
G
G
D
S
I
K
V
M
Q
L
I
H
Q
L
K
N
--
I
G
L
S
L
R
Y
D
Q
L
F
T
H
P
T
I
R
Q
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
69.08
35%
-75
- C1 -
5ES9
1
LGRA_BREPA
A:
[193-760]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
P
K
R
G
E
K
---
P
I
D
K
T
F
H
Q
L
F
E
Q
Q
V
E
M
T
P
D
H
V
A
V
V
D
-
R
G
Q
S
L
T
Y
K
Q
L
N
E
R
A
N
Q
L
A
H
H
L
R
G
K
G
V
K
P
D
D
Q
V
A
I
M
L
D
K
S
L
D
M
I
V
S
I
L
A
V
M
K
A
G
G
A
Y
V
P
I
D
P
D
Y
P
G
E
R
I
A
Y
M
L
A
D
S
S
-
A
A
I
L
L
--------
T
N
A
--------
L
H
-------
E
E
--
K
------
A
---
N
-------
G
A
-----
C
----------------
D
---
I
---------
I
D
VHDPDSY
S
E
N
T
N
-------
N
-
L
PHVN
R
---
P
------
D
D
L
V
Y
V
M
Y
T
S
----
L
A
K
G
V
M
I
E
H
H
N
L
V
N
F
C
E
W
Y
R
P
Y
F
---
G
V
T
P
A
D
K
A
L
V
Y
S
S
F
S
F
D
G
S
A
L
D
I
F
T
H
L
L
A
G
A
A
L
-
H
I
-
V
P
S
---
E
R
K
Y
D
L
D
A
L
N
D
Y
C
N
Q
E
G
I
T
I
S
Y
L
--------
P
T
G
A
A
E
Q
F
M
Q
--
M
D
N
----
Q
S
----------
F
R
V
V
--
I
T
G
------
G
D
V
L
K
K
I
E
R
N
G
-
T
---
Y
K
--
L
Y
N
G
Y
G
P
T
E
C
T
I
M
V
T
M
F
E
V
---
D
K
---
P
----
Y
A
N
------
I
P
I
G
K
P
-
I
D
R
T
R
I
L
I
L
D
-
E
A
L
A
L
Q
P
-
I
G
V
A
G
E
L
F
I
V
G
E
G
L
G
R
G
Y
L
N
R
P
E
L
T
A
E
K
F
--
I
V
H
P
--
Q
-
T
G
E
-
R
M
Y
R
T
G
D
R
A
R
F
L
P
D
G
N
I
E
F
L
G
R
L
D
N
L
V
K
I
R
G
Y
R
I
E
P
G
E
I
E
P
F
L
M
N
H
P
L
I
E
L
T
T
---
V
L
A
K
E
------
Q
-
A
D
G
R
---
K
Y
L
V
G
Y
Y
V
A
P
E
E
I
P
H
G
---------
E
L
R
E
W
L
G
N
D
L
P
D
Y
M
I
P
T
Y
F
V
H
M
-
K
A
F
P
L
T
A
N
G
K
V
D
R
R
A
L
P
D
V
---
Q
A
D
-
A
------
V
A
P
T
D
E
L
E
Q
Q
L
A
Q
V
W
S
H
V
L
G
I
P
Q
M
G
I
D
D
H
F
L
E
R
G
G
D
S
I
K
V
M
Q
L
I
H
Q
L
K
N
--
I
G
L
S
L
R
Y
D
Q
L
F
T
H
P
T
I
R
Q
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
65.95
35%
-70
- C1 -
5ES5
1
LGRA_BREPA
A:
[193-683]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
P
K
R
G
E
K
---
P
I
D
K
T
F
H
Q
L
F
E
Q
Q
V
E
M
T
P
D
H
V
A
V
V
D
-
R
G
Q
S
L
T
Y
K
Q
L
N
E
R
A
N
Q
L
A
H
H
L
R
G
K
G
V
K
P
D
D
Q
V
A
I
M
L
D
K
S
L
D
M
I
V
S
I
L
A
V
M
K
A
G
G
A
Y
V
P
I
D
P
D
Y
P
G
E
R
I
A
Y
M
L
A
D
S
S
-
A
A
I
L
L
--------
T
N
A
--------
L
H
-------
E
E
--
K
------
A
---
N
-------
G
A
-----
C
----------------
D
---
I
---------
I
D
VHDPDSY
S
E
N
T
N
-------
N
-
L
PHVN
R
---
P
------
D
D
L
V
Y
V
M
Y
T
S
G
S
T
G
L
A
K
G
V
M
I
E
H
H
N
L
V
N
F
C
E
W
Y
R
P
Y
F
---
G
V
T
P
A
D
K
A
L
V
Y
S
S
F
S
F
D
G
S
A
L
D
I
F
T
H
L
L
A
G
A
A
L
-
H
I
-
V
P
S
---
E
R
K
Y
D
L
D
A
L
N
D
Y
C
N
Q
E
G
I
T
I
S
Y
L
--------
P
T
G
A
A
E
Q
F
M
Q
--
M
D
N
----
Q
S
----------
F
R
V
V
--
I
T
G
------
G
D
V
L
K
K
I
E
R
N
G
-
T
---
Y
K
--
L
Y
N
G
Y
G
P
T
E
C
T
I
M
V
T
M
F
E
V
---
D
K
---
P
----
Y
A
N
------
I
P
I
G
K
P
-
I
D
R
T
R
I
L
I
L
D
-
E
A
L
A
L
Q
P
-
I
G
V
A
G
E
L
F
I
V
G
E
G
L
G
R
G
Y
L
N
R
P
E
L
T
A
E
K
F
--
I
V
H
P
--
Q
-
T
G
E
-
R
M
Y
R
T
G
D
R
A
R
F
L
P
D
G
N
I
E
F
L
G
R
L
D
N
L
V
K
I
R
G
Y
R
I
E
P
G
E
I
E
P
F
L
M
N
H
P
L
I
E
L
T
T
---
V
L
A
K
E
------
Q
-
A
D
G
R
---
K
Y
L
V
G
Y
Y
V
A
P
E
E
I
P
H
G
---------
E
L
R
E
W
L
G
N
D
L
P
D
Y
M
I
P
T
Y
F
V
H
M
-
K
A
F
P
L
T
A
N
G
K
V
D
R
R
A
L
P
D
V
---
Q
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
65.92
33%
-81
- C1 -
1AMU
4
GRSA_ANEMI
A:
[17-530]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
-
H
E
E
E
Q
Y
L
F
A
V
N
N
T
K
A
E
Y
P
-
R
D
-
K
T
I
H
Q
L
F
E
E
Q
V
S
K
R
P
N
N
V
A
I
V
C
E-
N
E
Q
L
T
Y
H
E
L
N
V
K
A
N
Q
L
A
R
I
F
I
E
K
G
I
G
K
D
T
L
V
G
I
M
M
E
K
S
I
D
L
F
I
G
I
L
A
V
L
K
A
G
G
A
Y
V
P
I
D
I
E
Y
P
K
E
R
I
Q
Y
I
L
D
D
S
Q
-
A
R
M
L
L
T
Q
------
K
H
L
--------
V
H
-------
L
I
--
H
------
N
---
I
--------------
Q
FN
G
Q
V
E
I
FEEDTIKIR
E
---
G
---------
T
N
-------
L
H
-
V
P
-------
S
-
K
----
S
---
T
-------
D
L
A
Y
V
I
Y
T
S
-----
P
K
G
T
M
L
E
H
K
G
I
S
N
L
K
V
F
F
E
N
--SLN-
V
T
E
K
D
R
I
G
Q
F
A
S
I
S
F
D
A
S
V
W
E
M
F
M
A
L
L
T
G
A
S
L
-
Y
I
-
I
L
K
---
D
T
I
N
D
F
V
K
F
E
Q
Y
I
N
Q
K
E
I
T
V
I
T
L
--------
P
P
T
Y
V
V
H
L
------
D
----
P
E
R
I
L
--
S
---
I
Q
T
L
I
--
T
A
G
S
--
A
T
S
P
S
L
V
N
K
W
K
E
K
V
------
T
--
Y
I
N
A
Y
G
P
T
E
T
T
I
C
A
T
T
W
V
A
---
T
K
---
E
----
T
I
G
H
S
----
V
P
I
G
A
P
-
I
Q
N
T
Q
I
Y
I
V
D
E-
N
L
Q
L
K
S
-
V
G
E
A
G
E
L
C
I
G
G
E
G
L
A
R
G
Y
W
K
R
P
E
L
T
S
Q
K
F
--
V
D
N
P
F
-
V
-
P
G
E
-
K
L
Y
K
T
G
D
Q
A
R
W
L
S
D
G
N
I
E
Y
L
G
R
I
D
N
Q
V
K
I
R
G
H
R
V
E
L
E
E
V
E
S
I
L
L
K
H
M
Y
I
S
E
T
A
---
V
S
V
H
K
------
D
-
H
Q
E
Q
---
P
Y
L
C
A
-
Y
F
V
S
E
--
K
H
------
I
P
L
E
Q
L
R
Q
F
S
S
E
E
L
P
T
Y
M
I
P
S
-
Y
F
I
Q
L
D
K
M
P
L
T
S
N
G
K
I
D
R
K
Q
L
P
E
P
---
D
L
T
-
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
65.44
35%
-69
- C1 -
5ES5
1
LGRA_BREPA
B:
[193-685]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
P
K
R
G
E
K
---
P
I
D
K
T
F
H
Q
L
F
E
Q
Q
V
E
M
T
P
D
H
V
A
V
V
D
-
R
G
Q
S
L
T
Y
K
Q
L
N
E
R
A
N
Q
L
A
H
H
L
R
G
K
G
V
K
P
D
D
Q
V
A
I
M
L
D
K
S
L
D
M
I
V
S
I
L
A
V
M
K
A
G
G
A
Y
V
P
I
D
P
D
Y
P
G
E
R
I
A
Y
M
L
A
D
S
S
-
A
A
I
L
L
--------
T
N
A
--------
L
H
-------
E
E
--
K
------
A
---
N
-------
G
A
-----
C
----------------
D
---
I
---------
I
D
VHDPDSY
S
E
N
T
N
-------
N
-
L
PHVN
R
---
P
------
D
D
L
V
Y
V
M
Y
T
S
G
S
T
G
L
A
K
G
V
M
I
E
H
H
N
L
V
N
F
C
E
W
Y
R
P
Y
F
---
G
V
T
P
A
D
K
A
L
V
Y
S
S
F
S
F
D
G
S
A
L
D
I
F
T
H
L
L
A
G
A
A
L
-
H
I
-
V
P
S
---
E
R
K
Y
D
L
D
A
L
N
D
Y
C
N
Q
E
G
I
T
I
S
Y
L
--------
P
T
G
A
A
E
Q
F
M
Q
--
M
D
N
----
Q
S
----------
F
R
V
V
--
I
T
G
------
G
D
V
L
K
K
I
E
R
N
G
-
T
---
Y
K
--
L
Y
N
G
Y
G
P
T
E
C
T
I
M
V
T
M
F
E
V
---
D
K
---
P
----
Y
A
N
------
I
P
I
G
K
P
-
I
D
R
T
R
I
L
I
L
D
-
E
A
L
A
L
Q
P
-
I
G
V
A
G
E
L
F
I
V
G
E
G
L
G
R
G
Y
L
N
R
P
E
L
T
A
E
K
F
--
I
V
H
P
--
Q
-
T
G
E
-
R
M
Y
R
T
G
D
R
A
R
F
L
P
D
G
N
I
E
F
L
G
R
L
D
N
L
V
K
I
R
G
Y
R
I
E
P
G
E
I
E
P
F
L
M
N
H
P
L
I
E
L
T
T
---
V
L
A
K
E
------
Q
-
A
D
G
R
---
K
Y
L
V
G
Y
Y
V
A
P
E
E
I
P
H
G
---------
E
L
R
E
W
L
G
N
D
L
P
D
Y
M
I
P
T
Y
F
V
H
M
-
K
A
F
P
L
T
A
N
G
K
V
D
R
R
A
L
P
D
V
---
Q
A
D
-
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
HHSearch
65.11
23%
-74
- C1 -
2VSQ
2
SRFAC_BACSU
A:
[8-1060]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
Q
D
M
Y
Y
L
S
P
M
Q
E
G
M
L
F
H
A
I
L
N
P
G
Q
S
F
Y
L
E
Q
I
T
M
K
V
K
G
S
L
N
I
-
K
C
L
E
E
S
M
N
V
I
M
D
R
Y
D
V
F
R
T
V
F
I
H
E
K
V
K
R
P
V
Q
V
V
L
K
K
R
Q
F
H
I
E
--
E
I
D
L
T
HLT
G
S
E
Q
T
A
K
I
N
E
Y
K
E
Q
D
K
I
R
G
F
D
L
T
R
D
I
P
M
R
A
A
I
F
K
K
A
E
E
S
F
E
W
V
W
S
Y
H
H
I
I
L
D
G
W
C
F
G
I
V
V
Q
D
L
F
K
V
Y
N
A
L
R
E
Q
K
P
Y
S
L
-
P
P
V
K
P
Y
K
D
Y
I
K
W
L
E
K
Q
------
D
K
Q
A
S
L
R
Y
W
R
E
Y
L
E
G
F
E
G
Q
T
T
F
A
E
Q
R
K
K
Q
-
K
D
G
Y
E
P
K
E
L
L
F
S
P
S
E
A
E
T
K
A
F
T
E
L
A
K
S
Q
H
T
T
L
S
T
A
L
Q
A
V
W
S
V
L
I
S
R
Y
Q
Q
S
G
D
L
A
F
G
T
V
V
S
G
R
P
A
EI
K
G
V
E
H
M
V
G
L
F
I
N
V
V
P
R
R
V
K
L
S
E
G
I
T
F
N
G
L
L
K
R
L
Q
E
Q
S
L
Q
S
E
P
H
Q
Y
V
P
L
Y
D
I
Q
S
Q
A
D
Q
------
P
K
L
I
D
H
I
I
V
F
E
N
Y
P
L
Q
D
A
K
N
E
E
---------
S
S
E
N
G
F
D
M
V
D
V
-
H
V
F
E
K
S
N
Y
D
L
N
L
M
A
S
--
P
G
D
E
M
L
I
K
L
A
Y
N
E
N
V
F
D
E
A
F
I
L
R
L
K
S
Q
L
L
T
A
I
Q
Q
L
I
Q
N
P
D
Q
P
V
S
T
I
N
L
V
D
D
R
E
R
E
F
L
L
------------------------------------------------------
T
-----------------------------------------------------------------
G
L
---------
N
-----------
P
PAQA
H
E
T
K
P
L
T
Y
W
F
K
E
A
V
N
A
NPDAPALTYSG
Q
T
L
S
Y
R
E
L
D
E
E
A
N
R
I
A
R
R
L
Q
K
H
GAGKG
S
V
V
A
L
YTKRS
L
E
L
V
I
G
I
L
G
V
L
K
A
G
A
A
Y
L
P
V
DPKLP
E
D
R
I
S
Y
M
L
A
D
S
AAA
C
L
L
T
H
QEMKEQAAELPYT
G
T
T
L
F
IDDQTRFEEQASDPA
T
A
I
D
PNDPA
Y
I
M
Y
T
S
GTT
G
K
P
K
G
N
I
T
T
H
A
N
I
Q
G
L
VKHVDYMAFSDQ
D
T
F
L
S
VSNYAFD
A
F
T
F
D
F
Y
A
S
M
L
N
A
A
R
L
I
I
A
D
EHTLLD
T
E
R
L
T
D
L
I
L
Q
E
NVN
V
M
F
A
T
T
A
L
F
N
L
L
T
D
A
GEDWMKGLR
C
I
L
F
G
GERAS
V
P
H
V
R
K
A
L
R
I
M
GPGK
L
I
N
C
Y
G
P
TEGTVFA
T
A
H
V
V
H
D
LPDSISSLPIGKP
I
S
N
A
S
V
Y
I
L
N
E
Q
S
Q
L
Q
P
F
G
A
V
G
E
L
C
I
S
G
M
G
V
S
K
G
Y
V
N
R
A
D
L
T
K
E
K
F
I
E
N
P
F
K
--
P
G
E
T
L
Y
R
T
G
D
L
A
R
W
L
P
D
G
T
I
E
Y
A
G
R
I
D
D
Q
V
K
I
R
G
HRIE
L
E
E
I
E
K
Q
L
Q
E
YPGVK
D
A
V
V
V
A
D
R
H
ESGD
A
S
I
N
A
Y
L
V
N
R
TQLSAE
D
V
K
A
H
L
KKQLPAYMVPQ
T
F
T
F
L
D
E
L
P
L
T
T
NGKVNKRLLPKPDQDQ
L
-------------------------------------------------------
A
E
E
W
I
G
P
R
N
E
M
E
E
T
I
A
Q
I
W
S
E
V
L
G
R
K
Q
I
G
I
H
D
D
F
F
A
L
G
G
H
A
L
K
A
M
T
A
A
S
R
I
K
K
E
L
G
I
D
L
P
V
K
L
L
F
E
A
P
T
I
A
G
I
S
A
Y
L
K
N
G
G
-----------------------------------
13
PsiBlast_PDB
65.06
32%
-79
- C1 -
1AMU
4
GRSA_ANEMI
A:
[39-530]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
I
H
Q
L
F
E
E
Q
V
S
K
R
P
N
N
V
A
I
V
C
-
E
N
E
Q
L
T
Y
H
E
L
N
V
K
A
N
Q
L
A
R
I
F
I
E
K
G
I
G
K
D
T
L
V
G
I
M
M
E
K
S
I
D
L
F
I
G
I
L
A
V
L
K
A
G
G
A
Y
V
P
I
D
I
E
Y
P
K
E
R
I
Q
Y
I
L
D
D
S
Q
-
A
R
M
L
L
--------
T
Q
K
--------
H
L
V
H
L
I
H
N
I
Q
F
--
N
------
G
---
Q
-------
V
E
-----
I
----------------
F
---
E
---------
E
D
-------
T
I
K
I
R
EGTNLHV
P
-
S
----
K
---
S
------
T
D
L
A
Y
V
I
Y
T
S
-----
P
K
G
T
M
L
E
H
K
G
I
S
N
L
K
V
F
F
E
N
S
L
---
N
V
T
E
K
D
R
I
G
Q
F
A
S
I
S
F
D
A
S
V
W
E
M
F
M
A
L
L
T
G
A
S
L
-
Y
I
-
I
L
K
---
D
T
I
N
D
F
V
K
F
E
Q
Y
I
N
Q
K
E
I
T
V
I
T
L
--------
P
P
T
----
Y
V
V
--
H
L
D
----
P
E
R
I
L
--
S
---
I
Q
T
L
I
--
T
A
G
S
--
A
T
S
P
S
L
V
N
K
W
K
E
K
V
-
T
---
Y
I
----
N
A
Y
G
P
T
E
T
T
I
C
A
T
T
W
V
A
---
T
K
---
E
----
T
I
G
H
S
----
V
P
I
G
A
P
-
I
Q
N
T
Q
I
Y
I
V
D
-
E
N
L
Q
L
K
S
-
V
G
E
A
G
E
L
C
I
G
G
E
G
L
A
R
G
Y
W
K
R
P
E
L
T
S
Q
K
F
--
V
D
N
P
F
-
V
-
P
G
E
-
K
L
Y
K
T
G
D
Q
A
R
W
L
S
D
G
N
I
E
Y
L
G
R
I
D
N
Q
V
K
I
R
G
H
R
V
E
L
E
E
V
E
S
I
L
L
K
H
M
Y
I
S
E
T
A
---
V
S
V
H
K
------
D
-
H
Q
E
Q
---
P
Y
L
C
A
-
Y
F
V
--------
S
E
K
H
I
P
L
E
Q
L
R
Q
F
S
S
E
E
L
P
T
Y
M
I
P
S
Y
F
I
Q
L
-
D
K
M
P
L
T
S
N
G
K
I
D
R
K
Q
L
P
E
P
---
D
L
T
F------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
HHSearch
64.90
23%
-74
- C1 -
4ZXH
3
?
A:
[12-1048]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
L
S
R
H
A
I
S
S
E
Q
L
G
I
W
Y
I
Q
R
L
E
P
T
C
S
A
Y
N
M
V
V
A
F
D
V
K
V
N
Q
S
L
G
N
K
P
I
E
I
L
E
A
V
M
H
D
Y
P
L
L
R
V
S
M
P
A
N
D
-
Q
G
I
E
Q
L
I
W
D
R
V
Y
P
N
I
I
F
S
D
A
R
H
I
------
E
A
S
D
L
T
Q
L
V
E
Q
D
T
K
Q
P
F
D
L
T
Q
P
P
L
W
R
I
H
C
Y
E
C
G
Q
N
H
Y
V
I
A
F
V
I
H
H
A
L
M
D
F
W
S
I
G
L
L
L
R
D
V
S
K
R
F
G
L
V
A
E
S
D
----
A
V
N
G
I
E
F
V
Q
Y
A
D
K
Q
Q
S
S
V
I
---
D
D
T
D
E
S
L
I
F
W
K
N
A
L
K
H
A
P
H
V
H
S
I
P
L
D
Y
P
R
P
A
V
Q
Q
H
K
G
S
S
L
V
F
R
V
S
E
S
V
S
S
G
L
V
N
L
A
K
D
Y
E
I
T
L
F
G
L
V
L
S
G
F
Y
V
L
L
H
K
L
S
N
E
N
N
L
V
I
A
T
P
V
A
G
R
L
E
--
R
S
L
R
N
A
L
G
Q
F
V
N
T
I
A
I
H
M
D
I
D
A
D
Q
T
L
R
Q
F
T
Q
Q
V
Q
E
Q
L
R
Q
S
L
K
H
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K
I
A
F
S
R
V
V
E
A
V
S
P
K
R
D
G
S
I
N
P
L
A
Q
I
G
M
F
W
E
R
L
G
G
M
D
E
F
K
E
L
LLPIQTP
A
T
L
V
G
Q
D
L
T
L
G
S
F
P
V
R
Q
Q
E
G
Q
L
D
I
T
L
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M
G
G
E
Y
Q
G
E
L
V
G
V
L
K
Y
N
T
D
L
F
S
A
Q
S
A
E
N
M
V
Q
L
L
Q
A
V
L
S
E
M
V
A
H
P
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R
K
I
V
E
L
D
I
A
P
D
Y
K
D
G
I
Q
F
EALRGKATDYAQHD
L
F
A
M
I
L
K
Q
I
D
E
R
GDNHALTSHTVS
Y
R
E
L
G
Q
H
I
A
G
I
A
E
Y
L
R
A
H
GITQG
D
R
V
G
L
M
L
D
RTAL
L
P
A
A
I
L
G
I
W
A
A
G
A
A
Y
V
P
LDPNFP
T
E
R
L
Q
N
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D
A
EPK
V
I
L
T
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TELMD
G
L
NVS
V
P
R
L
D
I
N
Q
A
G
V
V
A
LEQVR
E
T
L
A
F
G
DIA
Y
V
M
Y
T
SK------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
G
V
R
I
G
H
P
S
I
I
N
F
L
L
S
M
N
D
R
L
QVTTE
T
Q
L
L
A
ITTYAFDIS
I
L
E
L
L
I
PLMYG
G
V
V
H
VCP
R
E
V
S
Q
D
G
I
Q
L
V
D
Y
L
N
A
KSIN
V
L
Q
A
T
P
A
T
W
K
M
L
L
D
S
EWSGNAG
L
T
A
L
C
GGEALD
T
I
L
A
E
K
L
L
G
K
V
GCLWN
V
Y
G
P
TETTVWSSAARITDAKYIDLGEP------
L
A
N
T
Q
L
Y
V
L
D
E
Q
Q
R
L
V
P
P
G
V
M
G
E
L
W
I
G
G
D
G
L
A
V
D
Y
W
Q
R
P
E
L
T
D
A
Q
F
R
T
L
P
S
L
P
-
N
A
G
R
L
Y
R
T
G
D
K
V
C
L
R
T
D
G
R
L
T
H
H
G
R
L
D
F
Q
V
K
I
R
G
FRIE
L
G
E
I
E
N
V
L
K
Q
IDGIT
D
A
V
V
L
V
K
T
T
GDN
D
Q
K
L
V
---------------------------------------------------------
A
Y
V
T
G
QELD
I
A
G
L
K
K
N
L
Q
I
H
L
PAYMVPS
A
F
I
R
L
DEFPMTANKKLDRKAF
P
E
P
I
F
EQ
S
N
D
Y
V
A
P
R
D
P
I
E
I
E
L
C
T
T
F
E
Q
I
L
S
V
K
R
V
G
I
H
D
D
F
F
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L
G
G
H
S
L
L
A
V
K
L
V
N
H
L
K
K
A
F
G
T
E
L
S
V
A
L
L
A
Q
Y
S
T
V
E
R
L
G
E
I
I
R
E
N
K
-----------------------------------
42
Fugue
64.59
26%
-70
- C1 -
4DG9
1
?
A:
[18-604]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
L
D
L
Y
A
H
P
T
V
V
A
R
F
S
E
M
A
A
L
H
P
H
R
E
A
I
R
D
-
R
F
G
S
V
D
Y
R
Q
L
L
D
S
A
E
Q
L
S
D
Y
L
L
E
H
Y
P
Q
P
G
V
C
L
G
V
Y
G
E
Y
S
R
E
S
I
T
C
L
L
A
I
L
L
S
G
H
H
Y
L
Y
I
D
L
K
Q
P
A
A
W
N
A
E
L
C
R
Q
V
D
-
C
R
L
I
L
DCSTTPTP
A
N
G
--------
L
P
-------
C
V
--
P
------
V
---
R
-------
H
L
-----
P
----------------
A
---
A
---------
P
A
-------
S
V
A
R
P
-------
C
-
F
----
A
---
A
------
D
Q
I
A
Y
I
N
F
S
S
G
T
T
G
R
P
K
A
I
A
C
T
H
A
G
I
T
R
L
C
-
L
G
Q
S
F
L
---
A
F
A
P
Q
M
R
F
L
V
N
S
P
L
S
F
D
A
A
T
L
E
I
W
G
A
L
L
N
G
G
C
C
-
V
L
-
N
D
L
---
G
P
L
-
D
P
G
V
L
R
Q
L
I
G
E
R
G
A
D
S
A
W
L
--------
T
A
S
L
F
N
T
L
V
D
--
L
D
-----
P
D
C
L
G
--
G
---
L
R
Q
L
L
--
T
G
G
D
--
I
L
S
V
P
H
V
R
R
A
L
L
R
H
P
R
---
L
H
--
L
V
N
G
Y
G
P
T
E
N
T
T
F
T
C
C
H
V
V
T
--
D
D
---
D
----
L
E
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D
D
----
I
P
I
G
K
A
-
I
A
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T
A
V
L
L
L
D
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E
H
G
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A
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A
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A
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A
G
L
A
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Y
R
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D
A
A
R
T
R
A
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F
--
V
E
L
P
Y
R
G
-
R
L
L
-
R
A
Y
R
T
G
D
R
A
R
Y
D
E
Q
G
R
L
R
F
I
G
R
G
D
G
Q
V
K
L
N
G
Y
R
L
D
L
P
A
L
E
Q
R
F
R
R
Q
P
G
I
L
D
C
A
---
L
L
V
R
E
------
R
-
N
G
V
K
---
Q
L
L
C
A
-
W
T
G
K
A
-------------
D
A
S
P
Q
A
L
L
R
Q
L
P
T
W
Q
R
P
H
A
C
V
R
V
-
E
A
L
P
L
T
A
H
G
K
L
D
R
A
A
L
L
R
R
---
L
------------
E
L
D
P
D
Q
R
G
C
A
Q
L
W
S
E
L
L
G
---
C
E
V
G
A
D
F
F
L
C
G
G
N
S
L
L
A
L
Q
L
V
A
L
C
Q
S
A
G
A
G
A
N
L
G
L
A
D
L
Q
A
N
S
R
L
D
Q
F
S
R
L
L
R
S
H
G
L
A
P
E
R
L
L
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
64.20
32%
-80
- C1 -
1AMU
4
GRSA_ANEMI
B:
[39-530]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
I
H
Q
L
F
E
E
Q
V
S
K
R
P
N
N
V
A
I
V
C
-
E
N
E
Q
L
T
Y
H
E
L
N
V
K
A
N
Q
L
A
R
I
F
I
E
K
G
I
G
K
D
T
L
V
G
I
M
M
E
K
S
I
D
L
F
I
G
I
L
A
V
L
K
A
G
G
A
Y
V
P
I
D
I
E
Y
P
K
E
R
I
Q
Y
I
L
D
D
S
Q
-
A
R
M
L
L
--------
T
Q
K
--------
H
L
VHLIHN-
Q
F
--
N
------
G
---
Q
-------
V
E
-----
I
----------------
F
---
E
---------
E
D
-------
T
I
K
I
R
EGTNLHV
P
-
S
----
K
---
S
------
T
D
L
A
Y
V
I
Y
T
-----
N
P
K
G
T
M
L
E
H
K
G
I
S
N
L
K
V
F
F
E
N
S
L
---
N
V
T
E
K
D
R
I
G
Q
F
A
S
I
S
F
D
A
S
V
W
E
M
F
M
A
L
L
T
G
A
S
L
-
Y
I
-
I
L
K
---
D
T
I
N
D
F
V
K
F
E
Q
Y
I
N
Q
K
E
I
T
V
I
T
L
--------
P
P
T
----
Y
V
V
--
H
L
D
----
P
E
R
I
L
--
S
---
I
Q
T
L
I
--
T
A
G
S
--
A
T
S
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S
L
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N
K
W
K
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K
V
-
T
---
Y
I
----
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---
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---
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----
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V
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-
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N
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N
L
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G
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G
Y
W
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R
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T
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Q
K
F
--
V
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N
P
F
-
V
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K
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K
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L
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D
G
N
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E
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V
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L
L
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H
M
Y
I
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T
A
---
V
S
V
H
K
------
D
-
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Q
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---
P
Y
L
C
A
-
Y
F
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--------
S
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K
H
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Y
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N
G
K
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R
K
Q
L
P
E
P
---
D
L
T
F------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
64.19
34%
-81
- C1 -
4D57
5
?
A:
[30-516]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
I
H
Q
L
F
E
T
Q
V
E
R
T
P
E
A
V
A
V
L
S
-
E
Q
G
Q
L
T
Y
E
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L
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T
K
A
N
Q
L
A
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Y
L
R
T
L
G
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S
E
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L
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G
V
C
V
D
R
S
L
E
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V
I
G
L
L
A
I
L
K
A
G
G
A
Y
V
P
L
D
P
T
Y
P
R
E
R
L
T
Y
M
V
Q
D
A
Q
I
S
V
L
V
T
--------
Q
T
Q
--------
W
S
-------
N
L
I-
S
------
D
---
Y
-------
Q
G
-----
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V
I
C
LDSQ
W
A
K
I
A
----
S
---
Y
---------
S
Q
-------
E
N
L
V
N
-------
T
-
V
----
N
---
P
------
E
N
L
A
Y
V
I
Y
T
S
G
S
T
G
K
P
K
G
V
M
I
E
H
Q
S
L
V
N
F
T
K
L
A
I
A
Q
Y
---
Q
I
T
T
S
D
R
T
L
Q
F
V
S
I
S
F
D
V
A
A
E
E
I
Y
V
T
L
C
S
G
A
T
L
-
I
L
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R
T
E
---
E
M
I
S
S
I
P
S
F
V
Q
K
S
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D
W
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I
T
V
W
S
L
P
T
A
Y
W
H
L
L
V
N
E
L
V
K
S
K
I
A
--
L
P
D
-----------
S
---
L
R
L
V
I
--
I
G
G
E
--
R
V
Q
P
E
L
V
R
M
W
F
K
N
V
-
G
---
N
F
P
E
L
I
N
V
Y
G
P
T
E
G
T
I
A
V
S
L
C
R
L
SQL
T
E
---
S
----
Q
R
N
R
T
E---
I
P
I
G
K
S
L
G
E
N
I
S
V
Y
V
L
D
-
E
T
L
K
T
V
P
-
P
E
T
P
G
E
I
Y
I
G
G
T
A
L
A
R
G
Y
L
N
R
P
E
L
T
A
Q
K
F
--
I
Q
D
P
F
-
S
-
P
S
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-
R
L
Y
K
T
G
D
L
G
R
Y
L
A
D
G
N
L
E
Y
L
G
R
V
D
H
Q
V
K
I
N
G
F
R
V
E
L
G
E
I
E
T
V
L
L
Q
H
H
Q
V
A
Q
A
V
---
V
I
D
R
-----------------
R
L
V
A
-
Y
L
V
P
H
S
T
E
E
---
N
L
T
V
T
L
Q
Q
F
---
L
K
N
K
L
P
S
Y
M
I
P
A
T
F
V
V
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
64.07
34%
-81
- C1 -
4D56
5
?
A:
[30-516]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
I
H
Q
L
F
E
T
Q
V
E
R
T
P
E
A
V
A
V
L
S
-
E
Q
G
Q
L
T
Y
E
E
L
N
T
K
A
N
Q
L
A
H
Y
L
R
T
L
G
V
K
S
E
T
L
V
G
V
C
V
D
R
S
L
E
M
V
I
G
L
L
A
I
L
K
A
G
G
A
Y
V
P
L
D
P
T
Y
P
R
E
R
L
T
Y
M
V
Q
D
A
Q
I
S
V
L
V
T
--------
Q
T
Q
--------
W
S
-------
N
L
I-
S
------
D
---
Y
-------
Q
G
-----
Q
V
I
C
LDSQ
W
A
K
I
A
----
S
---
Y
---------
S
Q
-------
E
N
L
V
N
-------
T
-
V
----
N
---
P
------
E
N
L
A
Y
V
I
Y
T
S
G
S
T
G
K
P
K
G
V
M
I
E
H
Q
S
L
V
N
F
T
K
L
A
I
A
Q
Y
---
Q
I
T
T
S
D
R
T
L
Q
F
V
S
I
S
F
D
V
A
A
E
E
I
Y
V
T
L
C
S
G
A
T
L
-
I
L
-
R
T
E
---
E
M
I
S
S
I
P
S
F
V
Q
K
S
Q
D
W
Q
I
T
V
W
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L
P
T
A
Y
W
H
L
L
V
N
E
L
V
K
S
K
I
A
--
L
P
D
-----------
S
---
L
R
L
V
I
--
I
G
G
E
--
R
V
Q
P
E
L
V
R
M
W
F
K
N
V
-
G
---
N
F
P
E
L
I
N
V
Y
G
P
T
E
G
T
I
A
V
S
L
C
R
L
SQL
T
E
---
S
----
Q
R
N
R
T
E---
I
P
I
G
K
S
L
G
E
N
I
S
V
Y
V
L
D
-
E
T
L
K
T
V
P
-
P
E
T
P
G
E
I
Y
I
G
G
T
A
L
A
R
G
Y
L
N
R
P
E
L
T
A
Q
K
F
--
I
Q
D
P
F
-
S
-
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S
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-
R
L
Y
K
T
G
D
L
G
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Y
L
A
D
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N
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Y
L
G
R
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D
H
Q
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K
I
N
G
F
R
V
E
L
G
E
I
E
T
V
L
L
Q
H
H
Q
V
A
Q
A
V
---
V
I
D
R
-----------------
R
L
V
A
-
Y
L
V
P
H
S
T
E
E
---
N
L
T
V
T
L
Q
Q
F
---
L
K
N
K
L
P
S
Y
M
I
P
A
T
F
V
V
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
63.99
34%
-80
- C1 -
4D4I
4
?
A:
[30-515]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
I
H
Q
L
F
E
T
Q
V
E
R
T
P
E
A
V
A
V
L
S
-
E
Q
G
Q
L
T
Y
E
E
L
N
T
K
A
N
Q
L
A
H
Y
L
R
T
L
G
V
K
S
E
T
L
V
G
V
C
V
D
R
S
L
E
M
V
I
G
L
L
A
I
L
K
A
G
G
A
Y
V
P
L
D
P
T
Y
P
R
E
R
L
T
Y
M
V
Q
D
A
Q
I
S
V
L
V
T
--------
Q
T
Q
--------
W
S
-------
N
L
I-
S
------
D
---
Y
-------
Q
G
-----
Q
V
I
C
LDSQ
W
A
K
I
A
----
S
---
Y
---------
S
Q
-------
E
N
L
V
N
-------
T
-
V
----
N
---
P
------
E
N
L
A
Y
V
I
Y
T
S
G
S
T
G
K
P
K
G
V
M
I
E
H
Q
S
L
V
N
F
T
K
L
A
I
A
Q
Y
---
Q
I
T
T
S
D
R
T
L
Q
F
V
S
I
S
F
D
V
A
A
E
E
I
Y
V
T
L
C
S
G
A
T
L
-
I
L
-
R
T
E
---
E
M
I
S
S
I
P
S
F
V
Q
K
S
Q
D
W
Q
I
T
V
W
S
L
P
T
A
Y
W
H
L
L
V
N
E
L
V
K
S
K
I
A
--
L
P
D
-----------
S
---
L
R
L
V
I
--
I
G
G
E
--
R
V
Q
P
E
L
V
R
M
W
F
K
N
V
-
G
---
N
F
P
E
L
I
N
V
Y
G
P
T
E
G
T
I
A
V
S
L
C
R
L
SQL
T
E
---
S
----
Q
R
N
R
T
E---
I
P
I
G
K
S
L
G
E
N
I
S
V
Y
V
L
D
-
E
T
L
K
T
V
P
-
P
E
T
P
G
E
I
Y
I
G
G
T
A
L
A
R
G
Y
L
N
R
P
E
L
T
A
Q
K
F
--
I
Q
D
P
F
-
S
-
P
S
E
-
R
L
Y
K
T
G
D
L
G
R
Y
L
A
D
G
N
L
E
Y
L
G
R
V
D
H
Q
V
K
I
N
G
F
R
V
E
L
G
E
I
E
T
V
L
L
Q
H
H
Q
V
A
Q
A
V
---
V
I
D
R
-----------------
R
L
V
A
-
Y
L
V
P
H
S
T
E
E
---
N
L
T
V
T
L
Q
Q
F
---
L
K
N
K
L
P
S
Y
M
I
P
A
T
F
V
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
63.83
34%
-78
- C1 -
4D4G
4
?
A:
[30-514]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
I
H
Q
L
F
E
T
Q
V
E
R
T
P
E
A
V
A
V
L
S
-
E
Q
G
Q
L
T
Y
E
E
L
N
T
K
A
N
Q
L
A
H
Y
L
R
T
L
G
V
K
S
E
T
L
V
G
V
C
V
D
R
S
L
E
M
V
I
G
L
L
A
I
L
K
A
G
G
A
Y
V
P
L
D
P
T
Y
P
R
E
R
L
T
Y
M
V
Q
D
A
Q
I
S
V
L
V
T
--------
Q
T
Q
--------
W
S
-------
N
L
I-
S
------
D
---
Y
-------
Q
G
-----
Q
V
I
C
LDSQ
W
A
K
I
A
----
S
---
Y
---------
S
Q
-------
E
N
L
V
N
-------
T
-
V
----
N
---
P
------
E
N
L
A
Y
V
I
Y
T
S
G
S
T
G
K
P
K
G
V
M
I
E
H
Q
S
L
V
N
F
T
K
L
A
I
A
Q
Y
---
Q
I
T
T
S
D
R
T
L
Q
F
V
S
I
S
F
D
V
A
A
E
E
I
Y
V
T
L
C
S
G
A
T
L
-
I
L
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R
T
E
---
E
M
I
S
S
I
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S
F
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Q
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S
Q
D
W
Q
I
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W
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L
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A
Y
W
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L
L
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L
V
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S
K
I
A
--
L
P
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-----------
S
---
L
R
L
V
I
--
I
G
G
E
--
R
V
Q
P
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L
V
R
M
W
F
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N
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---
N
F
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I
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Y
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V
S
L
C
R
L
SQL
T
E
---
S
----
Q
R
N
R
T
E---
I
P
I
G
K
S
L
G
E
N
I
S
V
Y
V
L
D
-
E
T
L
K
T
V
P
-
P
E
T
P
G
E
I
Y
I
G
G
T
A
L
A
R
G
Y
L
N
R
P
E
L
T
A
Q
K
F
--
I
Q
D
P
F
-
S
-
P
S
E
-
R
L
Y
K
T
G
D
L
G
R
Y
L
A
D
G
N
L
E
Y
L
G
R
V
D
H
Q
V
K
I
N
G
F
R
V
E
L
G
E
I
E
T
V
L
L
Q
H
H
Q
V
A
Q
A
V
---
V
I
D
R
-----------------
R
L
V
A
-
Y
L
V
P
H
S
T
E
E
---
N
L
T
V
T
L
Q
Q
F
---
L
K
N
K
L
P
S
Y
M
I
P
A
T
F
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
62.94
34%
-67
- C1 -
3VNS
2
?
A:
[37-533]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
S
L
F
R
E
V
A
A
T
A
P
E
R
T
A
L
S
A
-
E
D
D
R
I
S
Y
G
R
L
D
A
W
S
D
A
V
A
R
T
L
L
A
E
G
V
R
P
G
D
R
V
A
L
R
M
S
P
G
A
E
A
I
V
A
I
L
A
I
L
K
C
G
A
A
Y
V
P
V
D
L
R
N
P
V
S
R
S
D
F
I
L
A
D
S
G
-
A
S
A
L
I
--------
G
E
P
--------
H
E
-------
G
C
--
A
------
V
---
T
-------
R
V
-----
V
----------------
R
---
T
---------
A
A
-------
V
A
E
C
K
-------
D
-
A
----
E
---
P
APGPGA
E
D
M
A
Y
V
I
Y
T
S
G
-
T
G
N
P
K
G
V
P
V
R
H
A
N
V
L
A
L
L
A
G
A
P
S
V
F
---
D
F
S
G
D
D
R
W
L
L
F
H
S
L
S
F
D
F
S
V
W
E
I
W
G
A
F
S
T
G
A
E
L
-
V
V
L
P
H
W
---
A
A
R
T
P
E
Q
Y
L
-
A
V
I
I
D
R
G
V
T
V
I
N
Q
--------
T
P
T
A
F
-
L
A
L
T
--
E
A
A
----
V
R
G
G
R
--
D
VSG
L
R
Y
V
I
--
F
G
G
E
--
K
L
T
A
P
M
L
R
P
W
A
K
A
F
-
G
LDR
P
R
--
L
V
N
G
Y
G
I
T
E
T
T
V
F
T
T
F
E
E
I
---
T
E
A
Y
L
A
----
Q
D
A
S
I
----
I
G
R
A
L
P
-
S
F
G
T
--
R
V
V
G
-
D
D
G
R
D
V
A
-
P
G
E
T
G
E
L
W
L
S
G
A
Q
L
A
E
G
Y
L
R
R
P
E
L
T
A
E
K
F
PE
V
----------V
R
Y
Y
R
T
G
D
L
V
S
E
L
P
D
G
R
F
A
Y
E
G
R
A
D
L
Q
I
K
L
R
G
Y
R
I
E
L
S
D
I
E
T
A
V
R
R
H
D
D
V
V
D
A
V
---
V
T
V
R
E
------
F
K
P
G
D
L
---
R
L
V
C
A
-
Y
V
A
R
----
E
G
S
A
T
T
A
R
E
L
---
R
N
H
I
K
T
L
L
P
A
Y
M
H
P
A
R
Y
L
P
L
-
P
G
L
P
R
T
V
N
G
K
V
D
R
A
A
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
62.78
34%
-70
- C1 -
3VNQ
1
?
A:
[37-533]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
S
L
F
R
E
V
A
A
T
A
P
E
R
T
A
L
S
A
-
E
D
D
R
I
S
Y
G
R
L
D
A
W
S
D
A
V
A
R
T
L
L
A
E
G
V
R
P
G
D
R
V
A
L
R
M
S
P
G
A
E
A
I
V
A
I
L
A
I
L
K
C
G
A
A
Y
V
P
V
D
L
R
N
P
V
S
R
S
D
F
I
L
A
D
S
G
-
A
S
A
L
I
--------
G
E
P
--------
H
E
-------
G
C
--
A
------
V
---
T
-------
R
V
-----
V
----------------
R
---
T
---------
A
A
-------
V
A
E
C
K
-------
D
-
A
----
E
----APGPGA
E
D
M
A
Y
V
I
Y
T
S
G
T
T
G
N
P
K
G
V
P
V
R
H
A
N
V
L
A
L
L
A
G
A
P
S
V
F
---
D
F
S
G
D
D
R
W
L
L
F
H
S
L
S
F
D
F
S
V
W
E
I
W
G
A
F
S
T
G
A
E
L
-
V
V
L
P
H
W
---
A
A
R
T
P
E
Q
Y
L
-
A
V
I
I
D
R
G
V
T
V
I
N
Q
--------
T
P
T
A
F
-
L
A
L
T
--
E
A
A
----
V
R
G
G
R
--
D
VSG
L
R
Y
V
I
--
F
G
G
E
--
K
L
T
A
P
M
L
R
P
W
A
K
A
F
-
G
LDR
P
R
--
L
V
N
G
Y
G
I
T
E
T
T
V
F
T
T
F
E
E
I
---
T
E
A
Y
L
A
----
Q
D
A
S
I
----
I
G
R
A
L
P
-
S
F
G
T
--
R
V
V
G
-
D
D
G
R
D
V
A
-
P
G
E
T
G
E
L
W
L
S
G
A
Q
L
A
E
G
Y
L
R
R
P
E
L
T
A
E
K
F
PE
V
----------V
R
Y
Y
R
T
G
D
L
V
S
E
L
P
D
G
R
F
A
Y
E
G
R
A
D
L
Q
I
K
L
R
G
Y
R
I
E
L
S
D
I
E
T
A
V
R
R
H
D
D
V
V
D
A
V
---
V
T
V
R
E
------
F
K
P
G
D
L
---
R
L
V
C
A
-
Y
V
A
R
----
E
G
S
A
T
T
A
R
E
L
---
R
N
H
I
K
T
L
L
P
A
Y
M
H
P
A
R
Y
L
P
L
-
P
G
L
P
R
T
V
N
G
K
V
D
R
A
A
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
59.27
37%
-63
- C1 -
5ES7
2
LGRA_BREPA
A:
[193-585]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
P
K
R
G
E
K
---
P
I
D
K
T
F
H
Q
L
F
E
Q
Q
V
E
M
T
P
D
H
V
A
V
V
D
-
R
G
Q
S
L
T
Y
K
Q
L
N
E
R
A
N
Q
L
A
H
H
L
R
G
K
G
V
K
P
D
D
Q
V
A
I
M
L
D
K
S
L
D
M
I
V
S
I
L
A
V
M
K
A
G
G
A
Y
V
P
I
D
P
D
Y
P
G
E
R
I
A
Y
M
L
A
D
S
S
-
A
A
I
L
L
--------
T
N
A
--------
L
H
-------
E
E
--
K
------
A
---
N
-------
G
A
-----
C
----------------
D
---
I
---------
I
D
VHDPDSY
S
E
N
T
N
-------
N
-
L
PHVN
R
---
P
------
D
D
L
V
Y
V
M
Y
T
S
-----
A
K
G
V
M
I
E
H
H
N
L
V
N
F
C
E
W
Y
R
P
Y
F
---
G
V
T
P
A
D
K
A
L
V
Y
S
S
F
S
F
D
G
S
A
L
D
I
F
T
H
L
L
A
G
A
A
L
-
H
I
-
V
P
S
---
E
R
K
Y
D
L
D
A
L
N
D
Y
C
N
Q
E
G
I
T
I
S
Y
L
--------
P
T
G
A
A
E
Q
F
M
Q
--
M
D
N
----
Q
S
----------
F
R
V
V
--
I
T
G
------
G
D
V
L
K
K
I
E
R
N
G
-
T
---
Y
K
--
L
Y
N
G
Y
G
P
T
E
C
T
I
M
V
T
M
F
E
V
---
D
K
---
P
----
Y
A
N
------
I
P
I
G
K
P
-
I
D
R
T
R
I
L
I
L
D
-
E
A
L
A
L
Q
P
-
I
G
V
A
G
E
L
F
I
V
G
E
G
L
G
R
G
Y
L
N
R
P
E
L
T
A
E
K
F
--
I
V
H
P
--
Q
-
T
G
E
-
R
M
Y
R
T
G
D
R
A
R
F
L
P
D
G
N
I
E
F
L
G
R
L
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------