@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2535c: (2016-05-11 )
MTHSQRRDKLKAQIAASGLDAMLISDLINVRYLSGFSGSNGALLVFADERDAVLATDGRYRTQAASQAPDLEVAIERAVGRYLAGRAGEAGVGKLGFESHVVTVDGLDALAGALEGKNTELVRASGTVESLREVKDAGELALLRLACEAADAALTDLVARGGLRPGRTERQVSRELEALMLDHGADAVSFETIVAAGANSAIPHHRPTDAVLQVGDFVKIDFGALVAGYHSDMTRTFVLGKAADWQLEIYQLVAEAQQAGRQALLPGAELRGVDAAARQLIADAGYGEHFGHGLGHGVGLQIHEAPGIGVTSAGTLLAGSVVTVEPGVYLPGRGGVRIEDTLVVAGGTPKMPETAGQTPELLTRFPKELAIL
Atome Classification :
(32 SA)
.........10........20........-----30-----......--..-----40----.----........50.....--...60........70.--....-.-.---.--.80.---..--.....-------90-..--...-------....100.--....---..110.......----120.......130.......140.......150.......160.......170.......180-.-......190.......200.....---..210.......220.....-..230.....-..240.......250.......260....-...270....------------------.------------------..280.......290.......--300....-...310-......-..320.......330--------..-.....340...-.-....350.......360.......370
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MT
H
S
Q
R
R
D
K
L
K
A
Q
I
A
AS
G
L
D
A
M
L
I
S
D
L
I
N
-----
V
R
-----
Y
LSGFS--GS-----N-----
G
----
A
L
L
V
F
ADER
D
A
V
L
AT--DGRYRTQAASQAP
D
-
L
--
E
V
A
I
-
E
-
R
---
A
--
V
G
R
Y
---
L
A--GRAGE-------A--GV--GKL-------GFE
S
H
V
V
T
--VD
G
L
---
D
A
L
A
G
A
LEGKN
T
----
E
L
V
RAS
G
T
V
E
S
L
R
E
V
K
D
A
G
E
L
A
L
L
R
L
A
C
E
A
A
D
A
A
L
T
D
L
V
A
RGGLRPG
R
T
E
R
Q
V
S
R
E
L
E
A
L
M
LD-H-GADA
V
S
F
E
T
IVAAGANSAIPHHRP---
T
D
A
V
LQVG
D
F
V
K
I
D
F
G
A
L
V
A
-
G
Y
HSD
M
T
R
T
F
-
V
LGKAAD
W
Q
L
E
I
Y
Q
L
V
A
E
A
Q
QA
G
R
Q
ALLP-GAELR
G
V
D
A
A
------------------
A
------------------
R
Q
L
I
ADAGYG
E
H
FGHGLGHGV
G
--
L
Q
I
HEAP-GIGVT--SAG
T
L
L
-AG
S
V
V
T
VEP
G
V
Y
LPG--------RG-G
V
R
I
E
D
T
-
L
V
V-A-GGTPKMPETAGQ
T
P
E
L
L
T
R
F
P
K
E
LAIL
51
HHSearch
94.99
42%
-89
- C1 -
3Q6D
2
?
A:
[2-356]
-
N
A
M
E
K
I
E
R
L
R
S
A
F
D
E
A
G
I
D
G
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L
L
T
N
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S
-----
R
R
-----
Y
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A
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F
T
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A
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----
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L
I
S
K
K
-
R
-
A
Q
F
I
T
--
D
F
R
Y
V
E
Q
A
S
K
Q
A
V
G
-
Y
--
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I
V
Q
-
H
-
A
G--
L
--
I
I
D
E
---
V
A
--
K
Q
V
K
E
-------
L
--
G
I
--
Q
K
L
-------
G
F
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--
Y
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Y
---
S
A
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K
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A
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---
A
----
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F
I
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L
V
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K
L
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L
I
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I
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A
A
Q
I
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A
A
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I
L
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--
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V
S
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V
S
N
E
L
E
F
F
M
R
K
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Q
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G
A
T
S
S
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F
D
I
I
V
A
S
G
L
R
S
A
L
P
H
G
V
A
---
S
E
K
V
I
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T
G
D
F
V
T
L
D
F
G
A
Y
Y
K
-
G
Y
C
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D
I
T
R
T
I
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A
V
G
E
P
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K
L
K
E
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Y
N
I
V
L
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L
R
G
V
N
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I
K
A
-
G
L
T
G
R
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A
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A
L
------------------
T
------------------
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G
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Y
F
G
H
S
T
G
H
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--
L
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P
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L
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R
--
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D
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V
L
E
-
P
G
M
A
V
T
V
E
P
G
I
Y
I
P
G
--------
I
G
-
G
V
R
I
E
D
D
-
I
I
V
-
T
-
S
E
G
----------
N
E
V
I
T
K
S
P
K
E
L
I
I
L
21
PsiBlast_CBE
93.22
39%
-87
- C1 -
3Q6D
2
?
D:
[5-356]
----
E
K
I
E
R
L
R
S
A
F
D
E
A
G
I
D
G
I
L
L
T
N
E
H
S
-----
R
R
-----
Y
M
A
N
F
T
--
G
T
-----
A
-----
G
----
V
V
L
I
--
S
K
K
R
A
Q
F
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T
--
D
F
R
Y
V
E
Q
A
S
K
Q
A
V
G
-
Y
--
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I
-
V
-
Q
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H
---
A
GL
I
I
D
E
---
V
A
--
K
Q
V
K
E
-------
L
--
G
I
--
Q
K
L
-------
G
F
E
Q
D
T
L
T
--
Y
S
S
Y
---
S
A
H
K
E
A
I
---
D
A
----
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F
I
P
T
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G
L
V
E
K
L
R
L
I
K
T
D
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I
K
I
L
K
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A
A
Q
I
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D
A
A
F
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H
I
L
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F
--
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R
P
G
V
S
E
I
E
V
S
N
E
L
E
F
F
M
R
K
-
Q
-
G
A
T
S
S
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F
D
I
I
V
A
S
G
L
R
S
A
L
P
H
G
V
A
---
S
E
K
V
I
E
T
G
D
F
V
T
L
D
F
G
A
Y
Y
K
-
G
Y
C
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D
I
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R
T
I
-
A
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D
K
L
K
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Y
N
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A
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G
V
N
G
I
K
A
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G
L
T
G
R
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A
D
A
L
------------------
T
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R
D
Y
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G
Y
G
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A
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P
G
I
Y
I
P
G
--------
I
G
-
G
V
R
I
E
D
D
-
I
I
V
------------
T
S
E
G
N
E
V
I
T
K
S
P
K
E
L
I
I
L
1
PsiBlast_PDB
92.93
39%
-89
- C1 -
3Q6D
2
?
A:
[5-356]
----
E
K
I
E
R
L
R
S
A
F
D
E
A
G
I
D
G
I
L
L
T
N
E
H
S
-----
R
R
-----
Y
M
A
N
F
T
--
G
T
-----
A
-----
G
----
V
V
L
I
--
S
K
K
R
A
Q
F
I
T
--
D
F
R
Y
V
E
Q
A
S
K
Q
A
V
G
-
Y
--
E
I
-
V
-
Q
-
H
---
A
GL
I
I
D
E
---
V
A
--
K
Q
V
K
E
-------
L
--
G
I
--
Q
K
L
-------
G
F
E
Q
D
T
L
T
--
Y
S
S
Y
---
S
A
H
K
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A
I
---
D
A
----
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F
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L
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F
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Q
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L
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A
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P
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A
---
S
E
K
V
I
E
T
G
D
F
V
T
L
D
F
G
A
Y
Y
K
-
G
Y
C
S
D
I
T
R
T
I
-
A
V
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P
S
D
K
L
K
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Y
N
I
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L
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A
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N
G
I
K
A
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G
L
T
G
R
E
A
D
A
L
------------------
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R
D
Y
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Y
G
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Y
F
G
H
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--
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E
A
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L
A
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--
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T
V
L
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G
M
A
V
T
V
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P
G
I
Y
I
P
G
--------
I
G
-
G
V
R
I
E
D
D
-
I
I
V
------------
T
S
E
G
N
E
V
I
T
K
S
P
K
E
L
I
I
L
23
PsiBlast_CBE
92.34
39%
-86
- C1 -
3Q6D
1
?
B:
[5-356]
----
E
K
I
E
R
L
R
S
A
F
D
E
A
G
I
D
G
I
L
L
T
N
E
H
S
-----
R
R
-----
Y
M
A
N
F
T
--
G
T
-----
A
-----
G
----
V
V
L
I
--
S
K
K
R
A
Q
F
I
T
--
D
F
R
Y
V
E
Q
A
S
K
Q
A
V
G
-
Y
--
E
I
-
V
-
Q
-
H
---
A
GL
I
I
D
E
---
V
A
--
K
Q
V
K
E
-------
L
--
G
I
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Q
K
L
-------
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F
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D
T
L
T
--
Y
S
S
Y
---
S
A
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K
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A
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---
D
A
----
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L
V
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A
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I
L
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P
G
V
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N
E
L
E
F
F
M
R
K
-
Q
-
G
A
T
S
S
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F
D
I
I
V
A
S
G
L
R
S
A
L
P
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G
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A
---
S
E
K
V
I
E
T
G
D
F
V
T
L
D
F
G
A
Y
Y
K
-
G
Y
C
S
D
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T
R
T
I
-
A
V
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S
D
K
L
K
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Y
N
I
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A
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K
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L
T
G
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E
A
D
A
L
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T
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D
Y
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Y
G
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G
H
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A
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G
I
Y
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--------
I
G
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R
I
E
D
D
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I
I
V
------------
T
S
E
G
N
E
V
I
T
K
S
P
K
E
L
I
I
L
22
PsiBlast_CBE
90.24
39%
-85
- C1 -
3Q6D
1
?
C:
[5-355]
----
E
K
I
E
R
L
R
S
A
F
D
E
A
G
I
D
G
I
L
L
T
N
E
H
S
-----
R
R
-----
Y
M
A
N
F
T
--
G
T
-----
A
-----
G
----
V
V
L
I
--
S
K
K
R
A
Q
F
I
T
--
D
F
R
Y
V
E
Q
A
S
K
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A
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G
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Y
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E
I
-
V
-
Q
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---
A
GL
I
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---
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A
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V
K
E
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G
I
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---
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L
V
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N
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F
M
R
K
-
Q
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G
A
T
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L
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A
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------------------
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L
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--------
I
G
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G
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D
D
-
I
I
V
------------
T
S
E
G
N
E
V
I
T
K
S
P
K
E
L
I
I
-
53
HHSearch
88.83
34%
-85
- C1 -
2ZSG
8
?
A:
[2-359]
----
D
R
S
E
R
L
I
Q
L
I
S
E
E
G
I
D
A
F
L
I
M
N
I
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N
SA
R
A
S
S
V
-----
Y
F
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F
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--
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----
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I
L
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T
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R
L
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F
--
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V
R
E
V------
D
--
F
I
D
V
---
L
K
--
K
T
V
N
D
-------
L
--
K
I
--
K
T
I
-------
A
L
E
E
E
R
V
S
--
L
S
L
F
---
R
R
I
S
S
A
F
G
D
--
R
----
K
F
I
G
I
D
D
E
V
K
Q
M
R
M
V
K
D
E
G
E
I
E
K
I
K
Q
A
I
E
I
S
E
R
A
F
L
E
T
V
Q
Q
--
I
R
A
G
M
T
E
K
E
I
A
A
L
L
E
Y
T
M
R
K
-
E
-
G
A
E
G
V
A
F
D
T
I
V
A
S
G
C
R
S
A
L
P
H
G
K
A
---
S
D
K
V
V
E
R
G
D
V
I
V
I
D
F
G
A
T
Y
E
-
N
Y
C
A
D
I
T
R
V
V
-
S
I
G
E
P
S
D
E
V
K
E
V
H
S
I
V
L
E
A
Q
E
R
A
L
K
I
A
K
A
-
G
V
T
G
K
L
L
D
S
V
------------------
A
------------------
R
E
F
I
R
E
K
G
Y
G
E
F
F
G
H
S
L
G
H
G
I
G
--
L
E
V
H
E
G
P
-
A
I
S
F
R
--
N
D
S
P
L
P
-
E
N
V
V
F
T
V
E
P
G
I
Y
L
E
G
--------
K
F
-
G
I
R
I
E
E
D
-
V
V
L
-
K
-
E
Q
G
----------
C
E
I
L
T
T
L
P
R
S
I
F
V
V
4
PsiBlast_PDB
88.78
33%
-81
- C1 -
2ZSG
8
?
A:
[3-359]
-----
R
S
E
R
L
I
Q
L
I
S
E
E
G
I
D
A
F
L
I
M
N
I
E
N
-----
S
A
R
A
S
S
V
Y
F
S
G
F
T
--
G
S
-----
F
-----
S
----
I
I
L
I
S
E
N
T
R
--
L
L
I
T
--
D
S
R
Y
T
V
Q
A
-
K
Q
E
T
D
-
F
--
E
V
R
--
E
-
V
--------
D
F
I
D
V
L
K
--
K
T
V
N
D
-------
L
--
K
I
--
K
T
I
-------
A
L
E
E
E
R
V
S
--
L
S
L
F
---
R
R
I
S
S
A
F
--
G
D
R
----
K
F
I
G
I
D
D
E
V
K
Q
M
R
M
V
K
D
E
G
E
I
E
K
I
K
Q
A
I
E
I
S
E
R
A
F
L
E
T
V
Q
Q
--
I
R
A
G
M
T
E
K
E
I
A
A
L
L
E
Y
T
M
R
K
-
E
-
G
A
E
G
V
A
F
D
T
I
V
A
S
G
C
R
S
A
L
P
H
G
K
A
---
S
D
K
V
V
E
R
G
D
V
I
V
I
D
F
G
A
T
Y
E
-
N
Y
C
A
D
I
T
R
V
V
-
S
I
G
E
P
S
D
E
V
K
E
V
H
S
I
V
L
E
A
Q
E
R
A
L
K
I
A
K
A
-
G
V
T
G
K
L
L
D
S
V
------------------
A
------------------
R
E
F
I
R
E
K
G
Y
G
E
F
F
G
H
S
L
G
H
G
I
G
--
L
E
V
H
E
G
P
-
A
I
S
F
R
--
N
D
S
P
L
P
-
E
N
V
V
F
T
V
E
P
G
I
Y
L
E
G
--------
K
F
-
G
I
R
I
E
E
D
-
V
V
L
------------
K
E
Q
G
C
E
I
L
T
T
L
P
R
S
I
F
V
V
25
PsiBlast_CBE
87.70
33%
-85
- C1 -
2ZSG
2
?
B:
[3-359]
-----
R
S
E
R
L
I
------
G
I
D
A
F
L
I
M
N
I
E
N
-----
S
A
R
A
S
S
V
Y
F
S
G
F
T
--
G
S
-----
F
-----
S
----
I
I
L
I
S
E
N
T
R
--
L
L
I
T
--
D
S
R
Y
T
V
Q
A
-
K
Q
E
T
D
-
F
--
E
V
R
--
E
-
V
---
K
--
G
G
D
F
I
D
V
L
K
--
K
T
V
N
D
-------
L
--
K
I
--
K
T
I
-------
A
L
E
E
E
R
V
S
--
L
S
L
F
---
R
R
I
S
S
A
F
--
G
D
R
----
K
F
I
G
I
D
D
E
V
K
Q
M
R
M
V
K
D
E
G
E
I
E
K
I
K
Q
A
I
E
I
S
E
R
A
F
L
E
T
V
Q
Q
--
I
R
A
G
M
T
E
K
E
I
A
A
L
L
E
Y
T
M
R
K
-
E
-
G
A
E
G
V
A
F
D
T
I
V
A
S
G
C
R
S
A
L
P
H
G
K
A
---
S
D
K
V
V
E
R
G
D
V
I
V
I
D
F
G
A
T
Y
E
-
N
Y
C
A
D
I
T
R
V
V
-
S
I
G
E
P
S
D
E
V
K
E
V
H
S
I
V
L
E
A
Q
E
R
A
L
K
I
A
K
A
-
G
V
T
G
K
L
L
D
S
V
------------------
A
------------------
R
E
F
I
R
E
K
G
Y
G
E
F
F
G
H
S
L
G
H
G
I
G
--
L
E
V
H
E
G
P
-
A
I
S
F
R
--
N
D
S
P
L
P
-
E
N
V
V
F
T
V
E
P
G
I
Y
L
E
G
--------
K
F
-
G
I
R
I
E
E
D
-
V
V
L
------------
K
E
Q
G
C
E
I
L
T
T
L
P
R
S
I
F
V
V
57
HHSearch
83.93
35%
-75
- C1 -
1WY2
6
PEPQ_PYRHO
A:
[2-351]
D
I
M
N
E
K
V
K
K
I
I
E
F
M
D
K
N
S
I
D
A
V
L
I
A
K
N
P
N
-----
V
Y
-----
Y
I
S
G
A
S
--
P
L
A
----
G
-----
G
----
Y
I
L
I
T
G
-
E
S
-
A
T
L
Y
V
--
P
E
L
E
Y
E
M
A
K
E
E
S
N
I
----
P
V
E
K
-
F
-----
K
--
K
M
D
E
---
F
Y
--
K
A
L
E
-----------
G
I
--
K
S
L
-------
G
I
E
S
-
S
L
P
--
Y
G
F
I
---
E
E
L
K
K
K
A
N
I
--
K
----
E
F
K
K
V
D
D
V
I
R
D
M
R
I
I
K
S
E
K
E
I
K
I
I
E
K
A
C
E
I
A
D
K
A
V
M
A
A
I
E
E
--
I
T
E
G
K
K
E
R
E
V
A
A
K
V
E
Y
L
M
K
M
-
N
-
G
A
E
K
P
A
F
D
T
I
I
A
S
G
Y
R
S
A
L
P
H
G
V
A
---
S
D
K
R
I
E
R
G
D
L
V
V
I
D
L
G
A
L
Y
Q
-
H
Y
N
S
D
I
T
R
T
I
-
V
V
G
S
P
N
E
K
Q
K
E
I
Y
E
I
V
L
E
A
Q
K
K
A
V
E
S
A
K
P
-
G
I
T
A
K
E
L
D
S
I
------------------
A
------------------
R
N
I
I
A
E
Y
G
Y
G
E
Y
F
N
H
S
L
G
H
G
V
G
--
L
E
V
H
E
W
P
-
R
V
S
Q
Y
--
D
E
T
V
L
R
-
E
G
M
V
I
T
I
E
P
G
I
Y
I
P
K
--------
I
G
-
G
V
R
I
E
D
T
-
I
L
I
-
T
-
K
N
G
----------
S
K
R
L
T
K
T
E
R
E
L
I
--
26
PsiBlast_CBE
82.97
33%
-73
- C1 -
1WN1
2
?
B:
[2-356]
-----
R
L
E
K
F
I
H
L
L
G
E
R
G
F
D
G
A
L
I
S
P
G
T
N
-----
L
Y
-----
Y
L
T
G
L
R
----------------------
L
H
E
V
G
E
R
L
A
I
L
A
V
SA
E
G
D
Y
R
F
L
A
P
S
----------
L
Y
-
E
-
N
---
V
--
V
N
N
F
---
P
A
TF
W
H
D
G
E
-------
N
--
P
Y
--
A
K
L
REILEEL
G
I
S
K
G
R
I
L
--
I
E
D
T
MRA
D
W
L
I
G
I
M
K
L
G
K
F
----
T
F
Q
P
L
S
S
L
I
K
E
L
R
M
I
K
D
K
E
E
V
K
M
M
E
H
A
S
R
I
A
D
K
V
F
E
E
I
L
T
W
D
L
I
--
G
M
K
E
R
E
L
A
L
K
I
E
-
L
L
I
R
-
E
-
L
S
D
G
I
A
F
E
P
I
V
A
S
G
E
N
A
A
N
P
H
H
E
P
---
G
E
R
K
I
R
K
G
D
I
I
I
L
D
Y
G
A
R
W
K
-
G
Y
C
S
D
I
T
R
T
I
-
G
L
G
E
L
D
E
R
L
V
K
I
Y
E
V
V
K
D
A
Q
E
S
A
F
K
A
V
R
E
-
G
I
K
A
K
D
V
D
S
R
------------------
A
------------------
R
E
V
I
S
K
A
G
Y
G
E
Y
F
I
H
R
T
G
H
G
L
G
--
L
D
V
H
E
E
P
-
Y
I
G
P
D
--
G
E
V
I
L
K
-
N
G
M
T
F
T
I
E
P
G
I
Y
V
P
G
--------
L
G
-
G
V
R
I
E
D
D
-
I
V
V
-
D
-
E
G
K
G
R
R
----------
L
T
K
A
E
R
E
L
I
I
L
7
PsiBlast_PDB
82.91
33%
-74
- C1 -
2HOW
-
?
A:
[2-356]
-----
R
L
E
K
F
I
H
L
L
G
E
R
G
F
D
G
A
L
I
S
P
G
T
N
-----
L
Y
-----
Y
L
T
G
L
R
----------------------
L
H
E
V
G
E
R
L
A
I
L
A
V
S
A
E
G
D
Y
R
F
L
A
P
S
----------
L
Y
-
E
-
N
---
V
--
V
N
N
F
---
P
A
T
F
W
H
D
G
E
-------
N
--
P
Y
--
A
K
L
R
E
I
L
E
E
L
G
I
S
K
G
R
I
L
--
I
E
D
T
MR
A
D
W
L
I
G
I
M
K
L
G
K
F
----
T
F
Q
P
L
S
S
L
I
K
E
L
R
M
I
K
D
K
E
E
V
K
M
M
E
H
A
S
R
I
A
D
K
V
F
E
E
I
L
T
W
D
L
I
--
G
M
K
E
R
E
L
A
L
K
I
E
-
L
L
I
R
-
E
-
L
S
D
G
I
A
F
E
P
I
V
A
S
G
E
N
A
A
N
P
H
H
E
P
---
G
E
R
K
I
R
K
G
D
I
I
I
L
D
Y
G
A
R
W
K
-
G
Y
C
S
D
I
T
R
T
I
-
G
L
G
E
L
D
E
R
L
V
K
I
Y
E
V
V
K
D
A
Q
E
S
A
F
K
A
V
R
E
-
G
I
K
A
K
D
V
D
S
R
------------------
A
------------------
R
E
V
I
S
K
A
G
Y
G
E
Y
F
I
H
R
T
G
H
G
L
G
--
L
D
V
H
E
E
P
-
Y
I
G
P
D
--
G
E
V
I
L
K
-
N
G
M
T
F
T
I
E
P
G
I
Y
V
P
G
--------
L
G
-
G
V
R
I
E
D
D
-
I
V
V
-
D
-
E
G
K
G
R
R
----------
L
T
K
A
E
R
E
L
I
I
L
24
PsiBlast_CBE
82.32
34%
-70
- C1 -
1WY2
3
PEPQ_PYRHO
B:
[5-346]
---
N
E
K
V
K
K
I
I
E
F
M
D
K
N
S
I
D
A
V
L
I
A
K
N
P
N
-----
V
Y
-----
Y
I
S
G
A
S
--
P
L
-----
A
-----
G
----
G
Y
I
L
I
T
G
E
S
A
T
L
Y
V
P
--
E
L
E
Y
--
E
M
A
K
E
E
S
N
-
I
--
P
V
E
K
-
F
-
K
---
K
--
M
D
E
F
---
Y
----
K
A
L
E
----------
G
I
--
K
S
L
-------
G
I
E
S
S
L
P
Y
G
F
I
E
E
L
---
K
K
K
A
N
I
K
E
F
K
---------
K
V
D
D
V
I
R
D
M
R
I
I
K
S
E
K
E
I
K
I
I
E
K
A
C
E
I
A
D
K
A
V
--
M
A
A
I
E
E
I
T
E
G
K
K
E
R
E
V
A
A
K
V
E
Y
L
M
K
M
-
N
-
G
A
E
K
P
A
F
D
T
I
I
A
S
G
Y
R
S
A
L
P
H
G
V
A
---
S
D
K
R
I
E
R
G
D
L
V
V
I
D
L
G
A
L
Y
Q
-
H
Y
N
S
D
I
T
R
T
I
-
V
V
G
S
P
N
E
K
Q
K
E
I
Y
E
I
V
L
E
A
Q
K
K
A
V
E
S
A
K
P
-
G
I
T
A
K
E
L
D
S
I
------------------
A
------------------
R
N
I
I
A
E
Y
G
Y
G
E
Y
F
N
H
S
L
G
H
G
V
G
--
L
E
V
H
E
W
P
-
R
V
S
Q
Y
--
D
E
T
V
L
R
-
E
G
M
V
I
T
I
E
P
G
I
Y
I
P
K
--------
I
G
-
G
V
R
I
E
D
T
I
L
I
T
-
K
-
N
G
S
K
R
L
T
K
T
------------------
3
PsiBlast_PDB
82.01
34%
-67
- C1 -
1WY2
6
PEPQ_PYRHO
A:
[5-346]
---
N
E
K
V
K
K
I
I
E
F
M
D
K
N
S
I
D
A
V
L
I
A
K
N
P
N
-----
V
Y
-----
Y
I
S
G
A
S
--
P
L
-----
A
-----
G
----
G
Y
I
L
I
T
G
E
S
A
T
L
Y
V
P
--
E
L
E
Y
--
E
M
A
K
E
E
S
N
-
I
--
P
V
E
K
-
F
-
K
---
K
--
M
D
E
F
---
Y
----
K
A
L
E
----------
G
I
--
K
S
L
-------
G
I
E
S
S
L
P
Y
G
F
I
E
E
L
---
K
K
K
A
N
I
K
E
F
K
---------
K
V
D
D
V
I
R
D
M
R
I
I
K
S
E
K
E
I
K
I
I
E
K
A
C
E
I
A
D
K
A
V
--
M
A
A
I
E
E
I
T
E
G
K
K
E
R
E
V
A
A
K
V
E
Y
L
M
K
M
-
N
-
G
A
E
K
P
A
F
D
T
I
I
A
S
G
Y
R
S
A
L
P
H
G
V
A
---
S
D
K
R
I
E
R
G
D
L
V
V
I
D
L
G
A
L
Y
Q
-
H
Y
N
S
D
I
T
R
T
I
-
V
V
G
S
P
N
E
K
Q
K
E
I
Y
E
I
V
L
E
A
Q
K
K
A
V
E
S
A
K
P
-
G
I
T
A
K
E
L
D
S
I
------------------
A
------------------
R
N
I
I
A
E
Y
G
Y
G
E
Y
F
N
H
S
L
G
H
G
V
G
--
L
E
V
H
E
W
P
-
R
V
S
Q
Y
--
D
E
T
V
L
R
-
E
G
M
V
I
T
I
E
P
G
I
Y
I
P
K
--------
I
G
-
G
V
R
I
E
D
T
I
L
I
T
-
K
-
N
G
S
K
R
L
T
K
T
------------------
44
Fugue
81.58
34%
-76
- C1 -
1WN1
2
?
A:
[1-356]
----
M
R
L
E
K
F
I
H
L
L
G
E
R
G
F
D
G
A
L
I
S
P
G
T
N
-----
L
Y
-----
Y
L
T
G
L
R
--
L
H
-----
E
-----
V
GER
L
A
I
L
A
V
S
A
E
G
D
Y
R
F
L
A
--
P
S
L
Y
E
N
V
V
-
N
N
F
P
A
-
T
--
F
W
H
D
-
G
-
E
---
N
--
P
Y
A
K
---
L
R
--
E
I
L
E
E
-------
L
--
G
I
SK
G
R
I
-------
L
I
E
D
T
M
R
------
A
---
D
W
L
I
G
I
M
K
L
G
K
F
----
T
F
Q
P
L
S
S
L
I
K
E
L
R
M
I
K
D
K
E
E
V
K
M
M
E
H
A
S
R
I
A
D
K
V
F
E
E
I
L
T
W
--
D
L
I
G
M
K
E
R
E
L
A
L
K
I
E
L
L
I
R
E
-
L
--
S
D
G
I
A
F
E
P
I
V
A
S
G
E
N
A
A
N
P
H
H
E
P
---
G
E
R
K
I
R
K
G
D
I
I
I
L
D
Y
G
A
R
W
K
-
G
Y
C
S
D
I
T
R
T
I
-
G
L
G
E
L
D
E
R
L
V
K
I
Y
E
V
V
K
D
A
Q
E
S
A
F
K
A
V
R
E
-
G
I
K
A
K
D
V
D
S
R
------------------
A
------------------
R
E
V
I
S
K
A
G
Y
G
E
Y
F
I
H
R
T
G
H
G
L
G
--
L
D
V
H
E
E
P
-
Y
I
G
P
D
--
G
E
V
I
L
K
-
N
G
M
T
F
T
I
E
P
G
I
Y
V
P
G
--------
L
G
-
G
V
R
I
E
D
D
-
I
V
V
-
D
-
E
G
----------
K
G
R
R
L
T
K
A
E
R
E
L
I
I
L
54
HHSearch
81.45
33%
-75
- C1 -
4FKC
10
?
A:
[13-377]
M
D
Y
K
R
R
I
H
K
F
Q
A
H
F
G
K
K
G
F
E
G
A
L
V
A
P
G
S
N
-----
F
Y
-----
Y
L
T
G
F
N
--
P
L
GTLER
L
-----
F
----
V
L
I
L
P
S
E
G
L
-
L
T
A
I
A
--
P
R
L
Y
E
K
E
L
E
E
-
F
N
--
G
--
E
V
V
L
-
W
-
S
DSE
N
--
P
Y
K
I
---
F
A
--
T
K
I
K
E
-------
T
FK
E
G
--
E
K
L
-------
L
I
D
D
-
T
M
P
--
V
G
V
F
---
L
K
A
K
D
I
F
D
K
--
Y
----
S
L
H
P
I
S
P
V
I
S
E
L
R
E
I
K
D
K
D
E
I
K
A
H
K
K
A
A
E
I
V
D
K
V
F
Y
R
F
I
E
G
--
K
L
E
G
K
S
E
R
E
L
A
N
R
I
E
Y
M
I
K
N
E
F
-
G
A
D
D
V
S
F
E
P
I
V
A
S
G
P
N
G
A
N
P
H
H
R
P
---
S
H
R
K
I
R
K
G
D
V
V
I
F
D
Y
G
A
K
Y
L
-
G
Y
C
S
D
V
T
R
T
V
-
V
V
G
P
P
S
E
E
V
K
K
V
Y
E
I
V
K
E
A
Q
E
T
A
V
Q
K
V
A
E
-
G
I
P
A
E
V
V
D
A
T
------------------
A
------------------
R
G
I
I
S
K
Y
G
Y
G
E
Y
F
I
H
R
T
G
H
G
L
G
--
I
D
V
H
E
E
P
-
Y
I
S
P
G
--
N
K
K
I
L
K
-
D
G
M
V
F
T
I
E
P
G
I
Y
L
Q
G
--------
K
F
-
G
V
R
I
E
D
D
-
V
A
L
-
V
-
D
K
K
----------
G
I
R
L
T
N
A
D
R
E
L
I
T
L
43
Fugue
81.41
33%
-80
- C1 -
1PV9
2
PEPQ_PYRFU
A:
[8-345]
---------
L
V
K
F
M
D
E
N
S
I
D
R
V
F
I
A
K
P
V
N
-----
V
Y
-----
Y
F
S
G
T
S
--
P
L
-----
G
-----
G
----
G
Y
I
I
V
D
G
D
E
A
T
L
Y
V
P
----
E
L
E
Y
E
M
A
K
E
E
S
K
-
L
--
P
V
V
K
-
F
-
K
---
K
--
F
D
E
I
---
Y
E
--
I
L
K
N
------------
T
--
E
T
L
-------
G
I
E
G
T
L
------
S
Y
---
S
M
V
E
N
F
K
E
K
S
V
K
----
E
F
K
K
I
D
D
V
I
K
D
L
R
I
I
K
T
K
E
E
I
E
I
I
E
K
A
C
E
I
A
D
K
A
V
M
A
A
I
E
E
--
I
T
E
G
K
R
E
R
E
V
A
A
K
V
E
Y
L
M
K
M
-
N
-
G
A
E
K
P
A
F
D
T
I
I
A
S
G
H
R
S
A
L
P
H
G
V
A
---
S
D
K
R
I
E
R
G
D
L
V
V
I
D
L
G
A
L
Y
N
-
H
Y
N
S
D
I
T
R
T
I
-
V
V
G
S
P
N
E
K
Q
R
E
I
Y
E
I
V
L
E
A
Q
K
R
A
V
E
A
A
K
P
-
G
M
T
A
K
E
L
D
S
I
------------------
A
------------------
R
E
I
I
K
E
Y
G
Y
G
D
Y
F
I
H
S
L
G
H
G
V
G
--
L
E
I
H
E
W
P
-
R
I
S
Q
Y
--
D
E
T
V
L
K
-
E
G
M
V
I
T
I
E
P
G
I
Y
I
P
K
--------
L
G
-
G
V
R
I
E
D
T
-
V
L
I
-
T
-
E
N
G
----------
A
K
R
L
T
K
T
E
R
-----
6
PsiBlast_PDB
80.90
33%
-73
- C1 -
1WN1
2
?
A:
[2-356]
-----
R
L
E
K
F
I
H
L
L
G
E
R
G
F
D
G
A
L
I
S
P
G
T
N
-----
L
Y
-----
Y
L
T
G
L
R
----------------------
L
H
E
V
G
E
R
L
A
I
L
A
V
S
A
E
G
D
Y
R
F
L
A
P
S
----------
L
Y
-
E
-
N
---
V
--
V
N
N
F
---
P
A
T
F
W
H
D
G
E
-------
N
--
P
Y
--
A
K
L
R
E
I
L
E
E
L
G
I
S
K
G
R
I
L
--
I
E
D
T
MR
A
D
W
L
I
G
I
M
K
L
G
K
F
----
T
F
Q
P
L
S
S
L
I
K
E
L
R
M
I
K
D
K
E
E
V
K
M
M
E
H
A
S
R
I
A
D
K
V
F
E
E
I
L
T
W
D
L
I
--
G
M
K
E
R
E
L
A
L
K
I
E
-
L
L
I
R
-
E
-
L
S
D
G
I
A
F
E
P
I
V
A
S
G
E
N
A
A
N
P
H
H
E
P
---
G
E
R
K
I
R
K
G
D
I
I
I
L
D
Y
G
A
R
W
K
-
G
Y
C
S
D
I
T
R
T
I
-
G
L
G
E
L
D
E
R
L
V
K
I
Y
E
V
V
K
D
A
Q
E
S
A
F
K
A
V
R
E
-
G
I
K
A
K
D
V
D
S
R
------------------
A
------------------
R
E
V
I
S
K
A
G
Y
G
E
Y
F
I
H
R
T
G
H
G
L
G
--
L
D
V
H
E
E
P
-
Y
I
G
P
D
--
G
E
V
I
L
K
-
N
G
M
T
F
T
I
E
P
G
I
Y
V
P
G
--------
L
G
-
G
V
R
I
E
D
D
-
I
V
V
-
D
-
E
G
K
G
R
R
----------
L
T
K
A
E
R
E
L
I
I
L
52
HHSearch
80.32
34%
-72
- C1 -
4EGE
22
?
A:
[13-375]
A
V
Y
A
R
R
L
A
A
A
A
A
A
T
E
Q
A
G
L
A
G
L
V
I
T
P
G
Y
D
-----
L
R
-----
Y
L
I
G
S
R
--
A
D
TFE
R
-
L
-----
T
----
A
L
V
L
P
A
S
G
V
-
P
T
I
V
L
--
P
R
L
E
L
A
S
L
K
E
S
A
A
S
D
L
GV
C
V
R
D
-
W
-
V
DGD
D
--
P
Y
Q
L
---
V
A
--
V
A
L
G
G
----------
A
P
--
A
A
T
-------
A
V
T
-
D
S
M
P
--
A
L
H
L
---
L
P
L
A
D
A
L
G
---
V
----
L
P
V
L
A
T
D
V
L
R
Q
L
R
M
V
K
E
A
A
E
V
D
A
L
A
K
A
G
A
A
I
D
R
V
H
A
R
V
P
A
F
--
L
V
P
G
R
T
E
A
Q
V
A
A
D
I
A
E
A
I
V
A
-
E
-
G
H
S
A
V
A
F
-
V
I
V
G
S
G
P
H
G
A
D
P
H
H
G
Y
---
S
D
R
K
L
Q
V
G
D
I
V
V
V
D
I
G
G
T
Y
E
P
G
Y
Y
S
D
S
T
R
T
Y
-
S
I
G
D
P
S
P
D
V
A
Q
Q
Y
S
A
L
Q
R
A
Q
R
A
A
V
D
A
V
R
P
-
G
V
T
A
A
Q
V
D
A
A
------------------
A
------------------
R
D
V
L
A
D
A
G
L
A
E
Y
F
V
H
R
T
G
H
G
I
G
--
L
C
V
H
E
E
P
-
Y
I
V
A
G
--
N
E
L
P
L
V
-
A
G
M
A
F
S
I
E
P
G
I
Y
F
P
G
--------
R
W
-
G
A
R
I
E
D
I
-
V
V
V
-
T
-
E
N
G
----------
A
L
S
V
N
N
R
P
H
E
L
M
V
-
56
HHSearch
79.76
33%
-74
- C1 -
1WN1
2
?
A:
[1-355]
----
M
R
L
E
K
F
I
H
L
L
G
E
R
G
F
D
G
A
L
I
S
P
G
T
N
-----
L
Y
-----
Y
L
T
G
L
R
--
L
H
-----
E
VGER
L
A
----
I
L
A
V
S
A
E
G
D
-
Y
R
F
L
A
--
P
S
L
Y
E
N
V
V
N
N
-
F
P
A
----
T
F
W
H
-
D
G
E
---
N
--
P
Y
A
K
---
L
R
--
E
I
L
E
E
-------
L
GI
S
K
--
G
R
I
-------
L
I
E
D
-
T
M
R
--
A
D
W
L
---
I
G
I
M
-
K
L
G
K
--
F
----
T
F
Q
P
L
S
S
L
I
K
E
L
R
M
I
K
D
K
E
E
V
K
M
M
E
H
A
S
R
I
A
D
K
V
F
E
E
I
L
T
W
--
D
L
I
G
M
K
E
R
E
L
A
L
K
I
E
L
L
I
R
E
-
L
-
S
D
-
G
I
A
F
E
P
I
V
A
S
G
E
N
A
A
N
P
H
H
E
P
---
G
E
R
K
I
R
K
G
D
I
I
I
L
D
Y
G
A
R
W
K
-
G
Y
C
S
D
I
T
R
T
I
-
G
L
G
E
L
D
E
R
L
V
K
I
Y
E
V
V
K
D
A
Q
E
S
A
F
K
A
V
R
E
-
G
I
K
A
K
D
V
D
S
R
------------------
A
------------------
R
E
V
I
S
K
A
G
Y
G
E
Y
F
I
H
R
T
G
H
G
L
G
--
L
D
V
H
E
E
P
-
Y
I
G
P
D
--
G
E
V
I
L
K
-
N
G
M
T
F
T
I
E
P
G
I
Y
V
P
G
--------
L
G
-
G
V
R
I
E
D
D
-
I
V
V
-
D
-
E
G
K
----------
G
R
R
L
T
K
A
E
R
E
L
I
I
-
9
PsiBlast_PDB
77.13
33%
-69
- C1 -
4FKC
8
?
A:
[13-357]
M
D
Y
K
R
R
I
H
K
F
Q
A
H
F
G
K
K
G
F
E
G
A
L
V
A
P
G
S
N
-----
F
Y
-----
Y
L
T
G
F
N
P
L
G
T
-----
L
-----
E
----
R
L
F
V
L
------
I
L
P
S
--
E
G
----
L
L
T
A
I
A
P
R
-
L
Y-
E
K
E
L
-
E
-
E
---
F
--
N
G
E
V
---
V
L
--
W
S
D
S
E
N
P
Y
K
I
F
A
T
--
K
I
--
K
E
T
-------
F
K
E
G
E
K
L
L
--
I
D
D
T
---
M
P
V
G
V
F
L
K
A
K
D
I
F
D
K
Y
S
L
H
P
I
S
P
V
I
S
E
L
R
E
I
K
D
K
D
E
I
K
A
H
K
K
A
A
E
I
V
D
K
V
F
Y
R
F
I
E
--
G
K
L
E
G
K
S
E
R
E
L
A
N
R
I
E
Y
M
I
K
N
-
E
F
G
A
D
D
V
S
F
E
P
I
V
A
S
G
P
N
G
A
N
P
H
H
R
P
---
S
H
R
K
I
R
K
G
D
V
V
I
F
D
Y
G
A
K
Y
L
-
G
Y
C
S
D
V
T
R
T
V
-
V
V
G
P
P
S
E
E
V
K
K
V
Y
E
I
V
K
E
A
Q
E
T
A
V
Q
K
V
A
E
-
G
I
P
A
E
V
V
D
A
T
------------------
A
------------------
R
G
I
I
S
K
Y
G
Y
G
E
Y
F
I
H
R
T
G
H
G
L
G
--
I
D
V
H
E
E
P
-
Y
I
S
P
G
--
N
K
K
I
L
K
-
D
G
M
V
F
T
I
E
P
G
I
Y
L
Q
G
--------
K
F
-
G
V
R
I
E
D
D
-
V
--------------------------------
13
PsiBlast_PDB
61.37
31%
-65
- C1 -
1N51
3
AMPP_ECOLI
A:
[162-428]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
D
W
R
P
V
V
H
E
M
R
L
F
K
S
P
E
E
I
A
V
L
R
R
A
G
E
I
T
A
M
A
H
T
R
A
M
E
K
--
C
R
P
G
M
F
E
Y
H
L
E
G
E
I
H
H
E
F
N
R
-
H
-
G
A
R
Y
P
S
Y
N
T
I
V
G
S
G
E
N
G
C
I
L
H
Y
T
E
---
N
E
C
E
M
R
D
G
D
L
V
L
I
D
A
G
C
E
Y
K
-
G
Y
A
G
D
I
T
R
T
F
P
V
N
G
K
F
T
Q
A
Q
R
E
I
Y
D
I
V
L
E
S
L
E
T
S
L
R
L
Y
R
P
-
G
T
S
I
L
E
V
T
G
E
V
V
R
I
M
V
S
G
L
V
K
L
GILKGD
V
------------------
D
E
L
I
A
Q
N
A
H
R
P
F
F
M
H
G
L
S
H
W
L
G
--
L
D
V
H
D
V
G
-
V
Y
G
Q
D
--
R
S
R
I
L
E
-
P
G
M
V
L
T
V
E
P
G
L
Y
I
A
P
DAEVPEQY
R
G
I
G
I
R
I
E
D
D
-
I
V
I
-
T
E
T
G
N
E
N
L
T
A
S
V
V
K
K
P
E
------------
15
PsiBlast_PDB
61.19
31%
-66
- C1 -
1WLR
3
AMPP_ECOLI
A:
[162-428]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
D
W
R
P
V
V
H
E
M
R
L
F
K
S
P
E
E
I
A
V
L
R
R
A
G
E
I
T
A
M
A
H
T
R
A
M
E
K
--
C
R
P
G
M
F
E
Y
H
L
E
G
E
I
H
H
E
F
N
R
-
H
-
G
A
R
Y
P
S
Y
N
T
I
V
G
S
G
E
N
G
C
I
L
H
Y
T
E
---
N
E
C
E
M
R
D
G
D
L
V
L
I
D
A
G
C
E
Y
K
-
G
Y
A
G
D
I
T
R
T
F
P
V
N
G
K
F
T
Q
A
Q
R
E
I
Y
D
I
V
L
E
S
L
E
T
S
L
R
L
Y
R
P
-
G
T
S
I
L
E
V
T
G
E
V
V
R
I
M
V
S
G
L
V
K
L
GILKGD
V
------------------
D
E
L
I
A
Q
N
A
H
R
P
F
F
M
H
G
L
S
H
W
L
G
--
L
D
V
H
D
V
G
-
V
Y
G
Q
D
--
R
S
R
I
L
E
-
P
G
M
V
L
T
V
E
P
G
L
Y
I
A
P
DAEVPEQY
R
G
I
G
I
R
I
E
D
D
-
I
V
I
-
T
E
T
G
N
E
N
L
T
A
S
V
V
K
K
P
E
------------
19
PsiBlast_PDB
61.17
31%
-65
- C1 -
2BHD
5
AMPP_ECOLI
A:
[162-428]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
D
W
R
P
V
V
H
E
M
R
L
F
K
S
P
E
E
I
A
V
L
R
R
A
G
E
I
T
A
M
A
H
T
R
A
M
E
K
--
C
R
P
G
M
F
E
Y
H
L
E
G
E
I
H
H
E
F
N
R
-
H
-
G
A
R
Y
P
S
Y
N
T
I
V
G
S
G
E
N
G
C
I
L
H
Y
T
E
---
N
E
C
E
M
R
D
G
D
L
V
L
I
D
A
G
C
E
Y
K
-
G
Y
A
G
D
I
T
R
T
F
P
V
N
G
K
F
T
Q
A
Q
R
E
I
Y
D
I
V
L
E
S
L
E
T
S
L
R
L
Y
R
P
-
G
T
S
I
L
E
V
T
G
E
V
V
R
I
M
V
S
G
L
V
K
L
GILKGD
V
------------------
D
E
L
I
A
Q
N
A
H
R
P
F
F
M
H
G
L
S
H
W
L
G
--
L
D
V
H
D
V
G
-
V
Y
G
Q
D
--
R
S
R
I
L
E
-
P
G
M
V
L
T
V
E
P
G
L
Y
I
A
P
DAEVPEQY
R
G
I
G
I
R
I
E
D
D
-
I
V
I
-
T
E
T
G
N
E
N
L
T
A
S
V
V
K
K
P
E
------------
30
PsiBlast_CBE
61.08
31%
-65
- C1 -
2BH3
7
AMPP_ECOLI
A:
[162-428]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
D
W
R
P
V
V
H
E
M
R
L
F
K
S
P
E
E
I
A
V
L
R
R
A
G
E
I
T
A
M
A
H
T
R
A
M
E
K
--
C
R
P
G
M
F
E
Y
H
L
E
G
E
I
H
H
E
F
N
R
-
H
-
G
A
R
Y
P
S
Y
N
T
I
V
G
S
G
E
N
G
C
I
L
H
Y
T
E
---
N
E
C
E
M
R
D
G
D
L
V
L
I
D
A
G
C
E
Y
K
-
G
Y
A
G
D
I
T
R
T
F
P
V
N
G
K
F
T
Q
A
Q
R
E
I
Y
D
I
V
L
E
S
L
E
T
S
L
R
L
Y
R
P
-
G
T
S
I
L
E
V
T
G
E
V
V
R
I
M
V
S
G
L
V
K
L
GILKGD
V
------------------
D
E
L
I
A
Q
N
A
H
R
P
F
F
M
H
G
L
S
H
W
L
G
--
L
D
V
H
D
V
G
-
V
Y
G
Q
D
--
R
S
R
I
L
E
-
P
G
M
V
L
T
V
E
P
G
L
Y
I
A
P
DAEVPEQY
R
G
I
G
I
R
I
E
D
D
-
I
V
I
-
T
E
T
G
N
E
N
L
T
A
S
V
V
K
K
P
E
------------
29
PsiBlast_CBE
61.06
31%
-64
- C1 -
2BN7
7
AMPP_ECOLI
A:
[162-428]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
D
W
R
P
V
V
H
E
M
R
L
F
K
S
P
E
E
I
A
V
L
R
R
A
G
E
I
T
A
M
A
H
T
R
A
M
E
K
--
C
R
P
G
M
F
E
Y
H
L
E
G
E
I
H
H
E
F
N
R
-
H
-
G
A
R
Y
P
S
Y
N
T
I
V
G
S
G
E
N
G
C
I
L
H
Y
T
E
---
N
E
C
E
M
R
D
G
D
L
V
L
I
D
A
G
C
E
Y
K
-
G
Y
A
G
D
I
T
R
T
F
P
V
N
G
K
F
T
Q
A
Q
R
E
I
Y
D
I
V
L
E
S
L
E
T
S
L
R
L
Y
R
P
-
G
T
S
I
L
E
V
T
G
E
V
V
R
I
M
V
S
G
L
V
K
L
GILKGD
V
------------------
D
E
L
I
A
Q
N
A
H
R
P
F
F
M
H
G
L
S
H
W
L
G
--
L
D
V
H
D
V
G
-
V
Y
G
Q
D
--
R
S
R
I
L
E
-
P
G
M
V
L
T
V
E
P
G
L
Y
I
A
P
DAEVPEQY
R
G
I
G
I
R
I
E
D
D
-
I
V
I
-
T
E
T
G
N
E
N
L
T
A
S
V
V
K
K
P
E
------------
14
PsiBlast_PDB
60.99
31%
-65
- C1 -
1WL6
6
AMPP_ECOLI
A:
[162-428]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
D
W
R
P
V
V
H
E
M
R
L
F
K
S
P
E
E
I
A
V
L
R
R
A
G
E
I
T
A
M
A
H
T
R
A
M
E
K
--
C
R
P
G
M
F
E
Y
H
L
E
G
E
I
H
H
E
F
N
R
-
H
-
G
A
R
Y
P
S
Y
N
T
I
V
G
S
G
E
N
G
C
I
L
H
Y
T
E
---
N
E
C
E
M
R
D
G
D
L
V
L
I
D
A
G
C
E
Y
K
-
G
Y
A
G
D
I
T
R
T
F
P
V
N
G
K
F
T
Q
A
Q
R
E
I
Y
D
I
V
L
E
S
L
E
T
S
L
R
L
Y
R
P
-
G
T
S
I
L
E
V
T
G
E
V
V
R
I
M
V
S
G
L
V
K
L
GILKGD
V
------------------
D
E
L
I
A
Q
N
A
H
R
P
F
F
M
H
G
L
S
H
W
L
G
--
L
D
V
H
D
V
G
-
V
Y
G
Q
D
--
R
S
R
I
L
E
-
P
G
M
V
L
T
V
E
P
G
L
Y
I
A
P
DAEVPEQY
R
G
I
G
I
R
I
E
D
D
-
I
V
I
-
T
E
T
G
N
E
N
L
T
A
S
V
V
K
K
P
E
------------
17
PsiBlast_PDB
60.73
31%
-63
- C1 -
2BHB
6
AMPP_ECOLI
A:
[162-428]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
D
W
R
P
V
V
H
E
M
R
L
F
K
S
P
E
E
I
A
V
L
R
R
A
G
E
I
T
A
M
A
H
T
R
A
M
E
K
--
C
R
P
G
M
F
E
Y
H
L
E
G
E
I
H
H
E
F
N
R
-
H
-
G
A
R
Y
P
S
Y
N
T
I
V
G
S
G
E
N
G
C
I
L
H
Y
T
E
---
N
E
C
E
M
R
D
G
D
L
V
L
I
D
A
G
C
E
Y
K
-
G
Y
A
G
D
I
T
R
T
F
P
V
N
G
K
F
T
Q
A
Q
R
E
I
Y
D
I
V
L
E
S
L
E
T
S
L
R
L
Y
R
P
-
G
T
S
I
L
E
V
T
G
E
V
V
R
I
M
V
S
G
L
V
K
L
GILKGD
V
------------------
D
E
L
I
A
Q
N
A
H
R
P
F
F
M
H
G
L
S
H
W
L
G
--
L
D
V
H
D
V
G
-
V
Y
G
Q
D
--
R
S
R
I
L
E
-
P
G
M
V
L
T
V
E
P
G
L
Y
I
A
P
DAEVPEQY
R
G
I
G
I
R
I
E
D
D
-
I
V
I
-
T
E
T
G
N
E
N
L
T
A
S
V
V
K
K
P
E
------------
16
PsiBlast_PDB
60.65
31%
-64
- C1 -
2BHA
3
AMPP_ECOLI
A:
[162-428]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
D
W
R
P
V
V
H
E
M
R
L
F
K
S
P
E
E
I
A
V
L
R
R
A
G
E
I
T
A
M
A
H
T
R
A
M
E
K
--
C
R
P
G
M
F
E
Y
H
L
E
G
E
I
H
H
E
F
N
R
-
H
-
G
A
R
Y
P
S
Y
N
T
I
V
G
S
G
E
N
G
C
I
L
H
Y
T
E
---
N
E
C
E
M
R
D
G
D
L
V
L
I
D
A
G
C
E
Y
K
-
G
Y
A
G
D
I
T
R
T
F
P
V
N
G
K
F
T
Q
A
Q
R
E
I
Y
D
I
V
L
E
S
L
E
T
S
L
R
L
Y
R
P
-
G
T
S
I
L
E
V
T
G
E
V
V
R
I
M
V
S
G
L
V
K
L
GILKGD
V
------------------
D
E
L
I
A
Q
N
A
H
R
P
F
F
M
H
G
L
S
H
W
L
G
--
L
D
V
H
D
V
G
-
V
Y
G
Q
D
--
R
S
R
I
L
E
-
P
G
M
V
L
T
V
E
P
G
L
Y
I
A
P
DAEVPEQY
R
G
I
G
I
R
I
E
D
D
-
I
V
I
-
T
E
T
G
N
E
N
L
T
A
S
V
V
K
K
P
E
------------
20
PsiBlast_PDB
58.98
31%
-64
- C1 -
1A16
4
AMPP_ECOLI
A:
[162-428]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
D
W
R
P
V
V
H
E
M
R
L
F
K
S
P
E
E
I
A
V
L
R
R
A
G
E
I
T
A
M
A
H
T
R
A
M
E
K
--
C
R
P
G
M
F
E
Y
H
L
E
G
E
I
H
H
E
F
N
R
-
H
-
G
A
R
Y
P
S
Y
N
T
I
V
G
S
G
E
N
G
C
I
L
H
Y
T
E
---
N
E
C
E
M
R
D
G
D
L
V
L
I
D
A
G
C
E
Y
K
-
G
Y
A
G
D
I
T
R
T
F
P
V
N
G
K
F
T
Q
A
Q
R
E
I
Y
D
I
V
L
E
S
L
E
T
S
L
R
L
Y
R
P
-
G
T
S
I
L
E
V
T
G
E
V
V
R
I
M
V
S
G
L
V
K
L
GILKGD
V
------------------
D
E
L
I
A
Q
N
A
H
R
P
F
F
M
H
G
L
S
H
W
L
G
--
L
D
V
H
D
V
G
-
V
Y
G
Q
D
--
R
S
R
I
L
E
-
P
G
M
V
L
T
V
E
P
G
L
Y
I
A
P
DAEVPEQY
R
G
I
G
I
R
I
E
D
D
-
I
V
I
-
T
E
T
G
N
E
N
L
T
A
S
V
V
K
K
P
E
------------
38
PsiBlast_CBE
56.80
32%
-61
- C1 -
4PV4
3
?
A:
[167-427]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
H
E
M
R
L
F
K
S
A
E
E
I
A
V
L
R
R
A
G
E
I
S
--
A
L
A
H
T
R
A
M
E
K
C
R
P
G
M
F
E
Y
Q
L
E
G
E
I
L
H
E
F
T
R
-
H
-
G
A
R
Y
P
A
Y
N
T
I
V
G
G
G
E
N
G
C
I
L
H
Y
T
E
---
N
E
C
E
L
R
D
G
D
L
V
L
I
D
A
G
C
E
Y
R
-
G
Y
A
G
D
I
T
R
T
F
P
V
N
G
K
F
T
P
A
Q
R
A
V
Y
D
I
V
L
A
A
I
N
K
S
L
T
L
F
R
P
-
G
T
S
I
R
E
V
T
E
E
------------------
V
V
R
I
M
V
V
G
L
V
E
L
GILKGD
I
E
Q
L
I
A
E
Q
A
H
R
P
F
F
M
H
G
L
S
H
W
L
G
--
M
D
V
H
D
V
G
-
D
Y
G
S
S
--
D
R
G
R
I
L
E
P
G
M
V
L
T
V
E
P
G
L
Y
I
A
P
DADVPPQY
R
G
I
G
I
R
I
E
D
D
-
I
V
I
T
A
-
T
G
N
E
N
L
T
A
S
V
V
K
D
P
D
------------
37
PsiBlast_CBE
55.84
32%
-61
- C1 -
4PV4
4
?
B:
[167-427]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
H
E
M
R
L
F
K
S
A
E
E
I
A
V
L
R
R
A
G
E
I
S
--
A
L
A
H
T
R
A
M
E
K
C
R
P
G
M
F
E
Y
Q
L
E
G
E
I
L
H
E
F
T
R
-
H
-
G
A
R
Y
P
A
Y
N
T
I
V
G
G
G
E
N
G
C
I
L
H
Y
T
E
---
N
E
C
E
L
R
D
G
D
L
V
L
I
D
A
G
C
E
Y
R
-
G
Y
A
G
D
I
T
R
T
F
P
V
N
G
K
F
T
P
A
Q
R
A
V
Y
D
I
V
L
A
A
I
N
K
S
L
T
L
F
R
P
-
G
T
S
I
R
E
V
T
E
E
------------------
V
VRIMVVGLVELGILKGDI
E
Q
L
I
A
E
Q
A
H
R
P
F
F
M
H
G
L
S
H
W
L
G
--
M
D
V
H
D
V
G
-
D
Y
G
S
S
--
D
R
G
R
I
L
E
P
G
M
V
L
T
V
E
P
G
L
Y
I
A
P
DADVPPQY
R
G
I
G
I
R
I
E
D
D
-
I
V
I
T
A
-
T
G
N
E
N
L
T
A
S
V
V
K
D
P
D
------------
39
PsiBlast_CBE
42.65
35%
-72
- C1 -
3CTZ
5
XPP1_HUMAN
A:
[379-542]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
F
P
T
I
S
S
T
G
P
T
G
A
I
I
H
Y
A
P
V
PE
T
N
R
T
L
S
L
D
E
V
Y
L
I
D
S
G
A
Q
Y
K
-
D
G
T
T
D
V
T
R
T
M
-
H
F
E
T
P
T
A
Y
E
K
E
C
F
T
Y
V
L
K
G
H
I
A
V
S
A
A
V
F
P
T
G
T
K
G
H
L
L
D
S
F
------------------
A
------------------
R
S
A
L
W
D
S
G
L
D
--
Y
L
H
G
T
G
H
G
V
G
SF
L
N
V
H
E
G
P
C
G
I
S
Y
K
TF
S
D
E
P
L
E
-
A
G
M
I
V
T
D
E
P
G
Y
Y
E
D
G
--------
A
F
-
G
I
R
I
E
N
V
-
V
L
V
------------------------------