@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2941: (2016-05-15 )
MSVRSLPAALRACARLQPHDPAFTFMDYEQDWDGVAITLTWSQLYRRTLNVAQELSRCGSTGDRVVISAPQGLEYVVAFLGALQAGRIAVPLSVPQGGVTDERSDSVLSDSSPVAILTTSSAVDDVVQHVARRPGESPPSIIEVDLLDLDAPNGYTFKEDEYPSTAYLQYTSGSTRTPAGVVMSHQNVRVNFEQLMSGYFADTDGIPPPNSALVSWLPFYHDMGLVIGICAPILGGYPAVLTSPVSFLQRPARWMHLMASDFHAFSAAPNFAFELAARRTTDDDMAGRDLGNILTILSGSERVQAATIKRFADRFARFNLQERVIRPSYGLAEATVYVATSKPGQPPETVDFDTESLSAGHAKPCAGGGATSLISYMLPRSPIVRIVDSDTCIECPDGTVGEIWVHGDNVANGYWQKPDESERTFGGKIVTPSPGTPEGPWLRTGDSGFVTDGKMFIIGRIKDLLIVYGRNHSPDDIEATIQEITRGRCAAISVPGDRSTEKLVAIIELKKRGDSDQDAMARLGAIKREVTSALSSSHGLSVADLVLVAPGSIPITTSGKVRRGACVEQYRQDQFARLDA
Atome Classification :
(20 SA)
--------....-----.....10........20........30........40........50...------....-.-60-........70........80........90...-...-..100--...---.....110.......120.......130.......140---....------------....150..------...-...160.-----.-.-....170.......180......-.190.......200.....-..210.......220....-...230...----....240.......250.......----260---.----.---....-..270.......-280.....-...290.......300.......310.......320.......330.......340.......350.......360.----------..-..--...--.370....-.------..-380.---......390.......400.......410.......420.......------430...-----..------.-..440---.........450........460.......470--........480----.----.-.----.----.---..490....-------------------..-------------------.500..----.------------------....510....--...520...----------....530.......540.......550.......560.......570---.........580
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------MS
V
R
-----
S
L
P
A
A
L
R
A
C
ARLQPHDPA
F
T
F
M
DYEQDWD
G
V
A
I
T
L
T
W
S
Q
L
Y
R
R
T
L
N
V
A
Q
E
------
L
S
RC-G-ST-G
D
R
V
V
I
SAPQ
G
L
E
Y
V
V
A
F
L
G
A
LQAG
R
I
A
V
P
L
SV-PQG-GVTD---ERS---DSVLSDSS
P
V
A
I
L
TT
S
S
A
V
D
D
V
V
Q
H
V
A
RRPGESPP
S
I
----
I
E
V
D
------------
L
L
DLD-APN------GYT-FKEDEYP-----S-
T
-
A
Y
L
Q
YTSGSTRT
P
A
G
V
V
M
SHQ
N
V
-
R
V
N
F
E
Q
L
M
S
G
YFADTDGIP-PP
N
S
A
L
V
S
W
L
P
F
Y
H
DM
G
L
V
-
I
G
I
C
A
P
I
LG----GY
P
A
V
L
T
S
P
V
S
F
L
Q
R
P
A
R
W
M
H
L
M
A
----SD----F----H---AFSA-APN
F
A
F
E
LAARR-TT-D
D
D
MA-
G
R
D
L
G
N
I
L
T
ILSGS
E
R
V
Q
A
A
T
I
K
R
F
A
D
R
F
A
R
F
N
L
Q
E
R
VIRPSYGL
A
E
A
T
V
Y
V
A
TSKPGQPPETVDFDTESLSAG--H----------AK-PC--AGG--
G
A
T
S
L
I
S
Y
-M------LP-RS
P
I
---
V
R
I
VDSDT
C
I
ECPDG
T
V
G
E
I
W
V
HGDNVANGYWQKPDESERTFG
G
K
I
------VT-PSP-----GT------P-EGP-----WLRTGDS
G
F
VT-DG
K
M
F
I
I
GRI
K
D
L
L
I
V
YGRN---HS
P
D
D
I
E
A
T
I
Q
----
E
----
I
-T----R----G---
R
C
A
A
I
SVPG-------------------DR-------------------
S
T
E
K
L
V
----
A
------------------
I
I
E
L
K
KRGDS
D
--
Q
D
A
M
A
R
L
G
A
----------
I
K
R
E
V
T
S
A
L
SSSHGL
S
V
A
D
L
V
L
VAPGS
I
P
ITTSGKVR
R
G
A
C
V
E
Q
Y
-----
R
Q
D
Q
F
ARLDA
1
PsiBlast_PDB
94.90
99%
-117
- C5 -
3T5A
-
FAA28_MYCTU
A:
[4-459]
-----------
R
-----
S
L
P
A
A
L
R
A
C
A
R
L
Q
P
H
D
P
A
F
T
F
M
D
Y
E
Q
D
W
D
G
V
A
I
T
L
T
W
S
Q
L
Y
R
R
T
L
N
V
A
Q
E
------
L
S
R
C
-
G
-
S
T
-
G
D
R
V
V
I
S
A
P
Q
G
L
E
Y
V
V
A
F
L
G
A
L
Q
A
G
R
I
A
V
P
L
S
V
-
P
Q
G
-
G
V
T
D
---
E
R
S
---
D
S
V
L
S
D
S
S
P
V
A
I
L
T
T
S
S
A
V
D
D
V
V
Q
H
V
A
------
P
P
S
I
----
I
E
V
D
------------
L
L
D
L
D
-
A
P
---------
T
-
F
K
E
D
E
Y
P
-----
S
-
T
-
A
Y
L
Q
Y
T
------
P
A
G
V
V
M
S
H
Q
N
V
-
R
V
N
F
E
Q
L
M
S
G
Y
F
A
D
T
D
G
I
P
-
P
P
N
S
A
L
V
S
W
L
P
F
Y
H
D
M
G
L
V
-
I
G
I
C
A
P
I
L
G
----
G
Y
P
A
V
L
T
S
P
V
S
F
L
Q
R
P
A
R
W
M
H
L
M
A
----
S
D
----
F
----
H
---
A
F
S
A
-
A
P
N
F
A
F
E
L
A
A
R
R
-
T
T
-
D
D
D
M
A
-
G
R
D
L
G
N
I
L
T
I
L
S
G
S
E
R
V
Q
A
A
T
I
K
R
F
A
D
R
F
A
R
F
N
L
Q
E
R
V
I
R
P
S
Y
W
L
A
E
A
T
V
Y
V
A
T
S
K
P
G
Q
P
P
E
T
V
D
F
D
T
E
S
L
S
A
G
--
H
----------
A
K
-
P
C
--
A
G
G
--
G
A
T
S
L
I
S
Y
-
M
------
L
P
-
R
S
P
I
---
V
R
I
V
D
S
D
T
C
I
E
C
P
D
G
T
V
G
E
I
W
V
H
G
D
N
V
A
N
G
Y
W
Q
K
P
D
E
S
E
R
T
F
G
G
K
I
------
V
T
-
P
S
P
-----
G
T
------
P
-
E
G
P
-----
W
L
R
T
G
D
S
G
F
V
T
-
D
G
K
M
F
I
I
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
Fugue
81.12
38%
-91
- C5 -
5EY9
5
FAA32_MYCMM
A:
[3-626]
YHNPFIVN
G
K
I
R
F
P
E
NT
N
L
V
R
H
V
E
K
W
A
R
V
R
G
D
K
L
A
Y
R
F
L
D
F
S
T
E
R
D
G
V
E
R
D
I
L
W
S
E
F
S
A
R
N
R
A
V
G
A
R
------
L
Q
Q
V
-
T
-
Q
P
-
G
D
R
I
A
I
L
C
P
Q
N
L
D
Y
L
I
S
F
F
G
A
L
Y
S
G
R
I
A
V
P
L
F
D
-
P
A
E
-
H
--
V
---
G
R
L
---
H
A
V
L
D
D
C
T
P
S
T
I
L
T
T
T
D
S
A
E
G
V
R
K
F
I
R
S
R
S
A
K
E
R
P
R
V
----
I
A
V
D
------------
A
V
P
T
E
-
V
A
S
------
T
W
Q
-
Q
P
N
E
--
L
-----
T
-
T
-
A
Y
L
Q
Y
T
-----
V
P
S
G
V
Q
I
T
H
L
N
L
-
P
T
N
V
L
Q
V
L
N
A
L
----
E
G
---
Q
E
G
D
R
G
V
S
W
L
P
F
F
H
D
M
G
L
I
-
T
V
L
L
A
S
V
L
G
-----
H
S
F
T
F
M
T
P
A
A
F
V
R
R
P
G
R
W
I
R
E
L
A
RKPG
E
T
----
G
----
G
---
T
F
S
A
-
A
P
N
F
A
F
E
H
A
A
M
R
G
V
P
-
R
D
D
E
P
-
P
L
D
L
S
N
V
K
G
I
L
N
G
S
E
P
V
S
P
A
S
M
R
K
F
F
K
A
F
E
P
Y
G
L
R
E
T
A
V
K
P
S
Y
G
L
A
E
A
T
L
F
V
S
T
T
P
M
D
E
V
P
T
V
I
H
V
D
R
D
E
L
N
K
Q
--
R
----------
F
V
-
E
V
--
A
A
D
AP
N
A
V
A
Q
V
S
A
G
K
------
V
G
-
V
D
E
W
---
A
V
I
V
D
T
E
T
A
S
E
L
P
D
G
Q
I
G
E
I
W
L
H
G
N
N
L
G
I
G
Y
W
G
K
E
E
E
S
A
Q
T
F
R
N
I
L
------
K
S
-
R
V
P
-----
E
S
HAEGAP
D
-
D
G
L
-----
W
V
R
T
G
D
Y
G
T
Y
F
-
K
G
H
L
Y
I
A
G
R
I
K
D
L
V
I
I
D
G
R
N
---
H
Y
P
Q
D
L
E
Y
T
A
Q
----
E
S
TKA
L
-
R
----
V
----
G
---
Y
V
A
A
F
S
V
P
A
-------------------
N
Q
-------------------
L
P
Q
K
V
F
----
D
DPHAGLSFDPEDT
S
E
Q
L
V
I
V
G
E
R
A
A
G
T
H
K
--
L
E
----
Y
Q
P
----------
I
A
D
D
I
R
A
A
I
A
V
G
H
G
V
T
V
R
D
V
L
L
V
S
A
G
T
I
P
R
T
S
S
G
K
I
G
R
R
A
C
R
T
A
Y
I
D
GSL
R
S
T
V
F
A
----
26
PsiBlast_CBE
79.70
36%
-87
- C5 -
5EY9
4
FAA32_MYCMM
B:
[29-616]
--------------------------
A
R
V
R
G
D
K
L
A
Y
R
F
L
D
F
S
T
E
R
D
G
V
E
R
D
I
L
W
S
E
F
S
A
R
N
R
A
V
G
A
R
------
L
Q
Q
V
-
T
-
Q
P
-
G
D
R
I
A
I
L
C
P
Q
N
L
D
Y
L
I
S
F
F
G
A
L
Y
S
G
R
I
A
V
P
L
F
D
-
P
A
E
---
H
V
---
G
R
L
---
H
A
V
L
D
D
C
T
P
S
T
I
L
T
T
T
D
S
A
E
G
V
R
K
F
I
R
S
R
S
A
K
E
R
P
R
V
----
I
A
V
D
------------
A
V
P
T
E
-
V
A
S
------
T
W
Q
-
Q
P
E
A
N
E
L
-----
T
-
T
-
A
Y
L
Q
Y
T
-----
V
P
S
G
V
Q
I
T
H
L
N
L
-
P
T
N
V
L
Q
V
L
N
A
L
E
G
Q
E
-------
G
D
R
G
V
S
W
L
P
F
F
H
D
M
G
L
I
-
T
V
L
L
A
S
V
L
-----
G
H
S
F
T
F
M
T
P
A
A
F
V
R
R
P
G
R
W
I
R
E
L
A
----
R
K
PGET
G
----
G
---
T
F
S
A
-
A
P
N
F
A
F
E
H
A
A
M
R
-
G
V
P
R
D
D
E
P
-
P
L
D
L
S
N
V
K
G
I
L
N
G
S
E
P
V
S
P
A
S
M
R
K
F
F
K
A
F
E
P
Y
G
L
R
E
T
A
V
K
P
S
Y
G
L
A
E
A
T
L
F
V
S
T
T
P
M
D
E
V
P
T
V
I
H
V
D
R
D
E
L
N
K
Q
--
R
----------
F
V
-
E
V
--
A
A
D
--
A
P
N
A
V
A
Q
V
-
S
------
A
G
-
K
V
G
V
D
E
W
A
V
I
V
D
T
E
T
A
S
E
L
P
D
G
Q
I
G
E
I
W
L
H
G
N
N
L
G
I
G
Y
W
G
K
E
E
E
S
A
Q
T
F
R
N
I
L
------
K
S
-
R
V
P
ESHAE
G
A
------
P
D
D
G
L
-----
W
V
R
T
G
D
Y
G
T
Y
F
-
K
G
H
L
Y
I
A
G
R
I
K
D
L
V
I
I
D
G
R
N
---
H
Y
P
Q
D
L
E
Y
T
A
Q
----
E
----
S
-
T
----
K
ALRV
G
---
Y
V
A
A
F
S
V
P
A
-------------------
N
Q
-------------------
L
P
Q
K
V
F
D
DPH
A
------------------
G
L
S
F
D
P
E
D
T
S
E
--
Q
L
V
I
V
G
E
R
A
A
GTHKLE
Y
Q
P
I
A
D
D
I
R
A
A
I
A
V
G
H
G
V
T
V
R
D
V
L
L
V
S
A
G
T
I
P
R
T
S
S
G
K
I
G
R
R
A
C
R
T
A
Y
---------------
50
HHSearch
79.51
39%
-96
- C5 -
5D6J
2
?
A:
[19-619]
-----------
S
-----
S
I
V
A
H
V
E
R
W
A
K
V
R
G
D
K
L
A
Y
R
F
L
D
F
S
T
E
R
D
G
V
P
R
D
L
T
W
A
Q
F
S
A
R
N
R
A
V
A
A
R
------
L
Q
Q
V
-
T
-
Q
P
-
G
D
R
V
A
I
L
C
P
Q
N
L
D
Y
L
V
A
F
F
G
A
L
Y
A
G
R
I
A
V
P
L
F
D
-
P
S
E
-
P
G
H
V
---
G
R
L
---
H
A
V
L
D
N
C
H
P
S
A
I
L
T
T
T
E
A
A
E
G
V
R
K
F
F
R
T
R
P
A
N
Q
R
P
R
V
----
I
A
V
D
------------
A
V
P
D
D
-
V
A
S
------
T
W
V
N
P
D
E
P
D
E
T
-----
T
-
I
-
A
Y
L
Q
Y
T
S
G
S
T
R
I
P
T
G
V
Q
I
T
H
L
N
L
-
A
T
N
V
V
Q
V
I
E
A
L
E
------
G
-
E
E
G
D
R
G
L
S
W
L
P
F
F
H
D
M
G
L
I
-
T
A
L
L
A
P
M
I
-----
G
H
Y
F
T
F
M
T
P
A
A
F
V
R
R
P
E
R
W
I
R
E
L
A
----
R
K
E---
G
----
D
T
G
G
T
I
S
V
-
A
P
N
F
A
F
D
H
A
A
A
R
-
G
V
P
K
P
G
S
P
-
P
L
D
L
S
N
V
K
A
V
L
N
G
S
E
P
I
S
A
A
T
V
R
R
F
N
E
A
F
G
P
F
G
F
P
P
K
A
I
K
P
S
Y
G
L
A
E
A
T
L
F
V
S
T
T
P
S
A
E
E
P
K
I
I
T
V
D
R
D
Q
L
N
S
G
--
R
----------
I
V
-
E
V
D
A
D
S
P
--
K
A
V
A
Q
A
S
A
-
G
------
K
V
G
I
A
E
W
---
A
V
I
V
D
A
E
S
A
T
E
L
P
D
G
Q
V
G
E
I
W
I
S
G
Q
N
M
G
T
G
Y
W
G
K
P
E
E
S
V
A
T
F
Q
N
I
L
KSRTNP
S
H
-
A
E
G
-----
A
T
------
D
-
D
A
T
-----
W
V
R
T
G
D
Y
G
A
F
Y
-
D
G
D
L
Y
I
T
G
R
V
K
D
L
V
I
I
D
G
R
N
---
H
Y
P
Q
D
L
E
Y
S
A
Q
----
E
----
A
-
S
K
---
A
----
I
RTG
Y
V
A
A
F
S
V
P
A
-------------------
N
Q
LP
D
E
V
F
E
NAHSG
I
K
R
D
PDD
T
S
E
Q
L
V
----
I
------------------
V
A
E
R
A
P
G
A
H
K
-------
L
D
I
G
P
----------
I
T
D
D
I
R
A
A
I
A
V
R
H
G
V
T
V
R
D
V
L
L
T
A
A
G
A
I
P
R
T
S
S
G
K
I
G
R
R
A
C
R
A
A
Y
-----
L
D
G
S
L
R
A
G
--
5
PsiBlast_PDB
79.02
36%
-87
- C5 -
5EY9
5
FAA32_MYCMM
A:
[29-615]
--------------------------
A
R
V
R
G
D
K
L
A
Y
R
F
L
D
F
S
T
E
R
D
G
V
E
R
D
I
L
W
S
E
F
S
A
R
N
R
A
V
G
A
R
------
L
Q
Q
V
-
T
-
Q
P
-
G
D
R
I
A
I
L
C
P
Q
N
L
D
Y
L
I
S
F
F
G
A
L
Y
S
G
R
I
A
V
P
L
F
D
-
P
A
E
---
H
V
---
G
R
L
---
H
A
V
L
D
D
C
T
P
S
T
I
L
T
T
T
D
S
A
E
G
V
R
K
F
I
R
S
R
S
A
K
E
R
P
R
V
----
I
A
V
D
------------
A
V
P
T
E
-
V
A
S
------
T
W
Q
-
Q
P
--
N
E
L
-----
T
-
T
-
A
Y
L
Q
Y
T
-----
V
P
S
G
V
Q
I
T
H
L
N
L
-
P
T
N
V
L
Q
V
L
N
A
L
E
G
Q
E
-------
G
D
R
G
V
S
W
L
P
F
F
H
D
M
G
L
I
-
T
V
L
L
A
S
V
L
-----
G
H
S
F
T
F
M
T
P
A
A
F
V
R
R
P
G
R
W
I
R
E
L
A
----
R
K
PGET
G
----
G
---
T
F
S
A
-
A
P
N
F
A
F
E
H
A
A
M
R
-
G
V
P
R
D
D
E
P
-
P
L
D
L
S
N
V
K
G
I
L
N
G
S
E
P
V
S
P
A
S
M
R
K
F
F
K
A
F
E
P
Y
G
L
R
E
T
A
V
K
P
S
Y
G
L
A
E
A
T
L
F
V
S
T
T
P
M
D
E
V
P
T
V
I
H
V
D
R
D
E
L
N
K
Q
--
R
----------
F
V
-
E
V
--
A
A
D
--
A
P
N
A
V
A
Q
V
-
S
------
A
G
-
K
V
G
V
D
E
W
A
V
I
V
D
T
E
T
A
S
E
L
P
D
G
Q
I
G
E
I
W
L
H
G
N
N
L
G
I
G
Y
W
G
K
E
E
E
S
A
Q
T
F
R
N
I
L
------
K
S
-
R
V
P
ESHAE
G
A
------
P
D
D
G
L
-----
W
V
R
T
G
D
Y
G
T
Y
F
-
K
G
H
L
Y
I
A
G
R
I
K
D
L
V
I
I
D
G
R
N
---
H
Y
P
Q
D
L
E
Y
T
A
Q
----
E
----
S
-
T
----
K
ALRV
G
---
Y
V
A
A
F
S
V
P
A
-------------------
N
Q
-------------------
L
P
Q
K
V
F
D
DPH
A
------------------
G
L
S
F
D
P
E
D
T
S
E
--
Q
L
V
I
V
G
E
R
A
A
GTHKLE
Y
Q
P
I
A
D
D
I
R
A
A
I
A
V
G
H
G
V
T
V
R
D
V
L
L
V
S
A
G
T
I
P
R
T
S
S
G
K
I
G
R
R
A
C
R
T
A
Y
---------------
24
PsiBlast_CBE
78.55
36%
-92
- C5 -
5EY8
1
?
C:
[20-611]
-----------------
S
I
V
A
H
V
E
R
W
A
K
V
R
G
D
K
L
A
Y
R
F
L
D
F
S
T
E
R
D
G
V
P
R
D
L
T
W
A
Q
F
S
A
R
N
R
A
V
A
A
R
------
L
Q
Q
V
-
T
-
Q
P
-
G
D
R
V
A
I
L
C
P
Q
N
L
D
Y
L
V
A
F
F
G
A
L
Y
A
G
R
I
A
V
P
L
F
D
-
P
S
E
---
H
V
---
G
R
L
---
H
A
V
L
D
N
C
H
P
S
A
I
L
T
T
T
E
A
A
E
G
V
R
K
F
F
R
T
R
P
A
N
Q
R
P
R
V
----
I
A
V
D
------------
A
V
P
D
D
-
V
A
S
------
T
W
V
-
N
P
D
E
P
D
E
-----
T
-
T
I
A
Y
L
Q
Y
T
----
R
I
P
T
G
V
Q
I
T
H
L
N
L
-
A
T
N
V
V
Q
V
I
E
A
L
E
G
E
E
-------
G
D
R
G
L
S
W
L
P
F
F
H
D
M
G
L
I
-
T
A
L
L
A
P
M
I
G
----
H
Y
F
T
F
M
T
-
P
A
A
F
V
R
R
P
E
R
W
I
R
E
L
A
----
R
K
----
E
GDT
G
G
---
T
I
S
V
-
A
P
N
F
A
F
D
H
A
A
A
R
-
G
V
-
P
K
P
G
S
P
P
L
D
L
S
N
V
K
A
V
L
N
G
S
E
P
I
S
A
A
T
V
R
R
F
N
E
A
F
G
P
F
G
F
P
P
K
A
I
K
P
S
Y
G
L
A
E
A
T
L
F
V
S
T
T
P
S
A
E
E
P
K
I
I
T
V
D
R
D
Q
L
N
S
G
--
R
I
V
E
V
D
ADSPK
A
V
-
A
Q
--
A
S
A
--
G
K
V
G
I
A
E
W
-
A
------
V
-----------
I
V
D
A
E
S
A
T
E
L
P
D
G
Q
V
G
E
I
W
I
S
G
Q
N
M
G
T
G
Y
W
G
K
P
E
E
S
V
A
T
F
Q
N
I
L
------
K
S
R
T
N
P
-----
S
H
------
A
-
E
G
A
TDD
A
T
W
V
R
T
G
D
Y
G
A
F
Y
-
D
G
D
L
Y
I
T
G
R
V
K
D
L
V
I
I
D
G
R
N
---
H
Y
P
Q
D
L
E
Y
S
A
Q
----
E
----
A
-
S
----
K
AIRT
G
---
Y
V
A
A
F
S
V
P
A
NQLP
D
E
V
F
E
NAHSGIKRDP
D
D
-------------------
T
S
E
Q
L
V
----
I
------------------
V
A
E
-
R
A
P
G
-----
L
D
----
I
G
P
----------
I
T
D
D
I
R
A
A
I
A
V
R
H
G
V
T
V
R
D
V
L
L
T
A
A
G
A
I
P
R
T
S
S
G
K
I
G
R
R
A
C
R
A
A
Y
---------------
52
HHSearch
78.31
33%
-88
- C5 -
3KXW
1
?
A:
[11-573]
-----------
Q
-----
S
L
V
D
V
V
R
L
R
A
L
H
S
P
N
K
K
S
C
T
F
L
N
K
E
-----
L
E
E
T
M
T
Y
E
Q
L
D
Q
H
A
K
A
I
A
A
T
------
L
Q
A
E
G
A
-
K
P
-
G
D
R
V
L
L
L
F
A
P
G
L
P
L
I
Q
A
F
L
G
C
L
Y
A
G
C
I
A
V
P
I
Y
P
-
P
A
Q
-
E
K
L
L
---
D
K
A
---
Q
R
I
V
T
N
S
K
P
V
I
V
L
M
I
A
D
H
I
K
K
F
T
A
----
N
P
K
F
L
K
I
P
A
----
I
A
L
E
------------
S
I
E
L
N
-
R
S
S
------
S
W
Q
-
P
T
S
I
K
S
N
-----
D
-
I
-
A
F
L
Q
Y
T
S
G
S
T
M
H
P
K
G
V
M
V
S
H
H
N
L
-
L
D
N
L
N
K
I
F
T
S
F
H
------
M
-
N
D
E
T
I
I
F
S
W
L
P
P
H
H
D
M
G
L
I
-
G
C
I
L
T
P
I
Y
G
----
G
I
Q
A
I
M
M
S
P
F
S
F
L
Q
N
P
L
S
W
L
K
H
I
T
----
K
Y
----
K
----
A
---
T
I
S
G
-
S
P
N
F
A
Y
D
Y
C
V
K
R
-
I
R
-
E
E
K
K
E
-
G
L
D
L
S
S
W
V
T
A
F
N
G
A
E
P
V
R
E
E
T
M
E
H
F
Y
Q
A
F
K
E
F
G
F
R
K
E
A
F
Y
P
C
Y
G
L
A
E
A
T
L
L
V
T
G
G
T
P
G
S
S
Y
K
T
L
T
L
A
K
E
Q
F
Q
D
H
--
R
----------
V
H
F
A
D
D-
N
S
P
--
G
S
Y
K
L
V
S
S
-
G
------
N
P
--
I
Q
E
---
V
K
I
I
D
P
D
T
L
I
P
C
D
F
D
Q
V
G
E
I
W
V
Q
S
N
S
V
A
K
G
Y
W
N
Q
P
E
E
T
R
H
A
F
A
G
K
I
------
K
D
-
D
------------------
A
I
-----
Y
L
R
T
G
D
L
G
F
L
H
-
E
N
E
L
Y
V
T
G
R
I
K
D
L
I
I
I
Y
G
K
N
---
H
Y
P
Q
D
I
E
F
S
L
M
----
H
----
S
-
P
LHHV
L
----
G
---
K
C
A
A
F
V
I
Q
E
-------------------
E
--------------------
H
E
Y
K
L
T
----
V
------------------
M
C
E
V
K
N
R
F
M
D
D
------
V
A
Q
D
N
----------
L
F
N
E
I
F
E
L
V
Y
E
N
H
Q
L
E
V
H
T
I
V
L
I
P
L
K
A
M
P
H
T
T
S
G
K
I
R
R
N
F
C
R
K
H
L
-----
L
D
K
T
L
P
I
V
--
23
PsiBlast_CBE
78.12
36%
-91
- C5 -
5EY8
1
?
D:
[20-611]
-----------------
S
I
V
A
H
V
E
R
W
A
K
V
R
G
D
K
L
A
Y
R
F
L
D
F
S
T
E
R
D
G
V
P
R
D
L
T
W
A
Q
F
S
A
R
N
R
A
V
A
A
R
------
L
Q
Q
V
-
T
-
Q
P
-
G
D
R
V
A
I
L
C
P
Q
N
L
D
Y
L
V
A
F
F
G
A
L
Y
A
G
R
I
A
V
P
L
F
D
-
P
S
E
---
H
V
---
G
R
L
---
H
A
V
L
D
N
C
H
P
S
A
I
L
T
T
T
E
A
A
E
G
V
R
K
F
F
R
T
R
P
A
N
Q
R
P
R
V
----
I
A
V
D
------------
A
V
P
D
D
-
V
A
S
------
T
W
V
-
N
P
D
E
P
D
E
-----
T
-
T
I
A
Y
L
Q
Y
T
S
-
S
T
R
I
P
T
G
V
Q
I
T
H
L
N
L
-
A
T
N
V
V
Q
V
I
E
A
L
E
G
E
E
-------
G
D
R
G
L
S
W
L
P
F
F
H
D
M
G
L
I
-
T
A
L
L
A
P
M
I
G
----
H
Y
F
T
F
M
T
-
P
A
A
F
V
R
R
P
E
R
W
I
R
E
L
A
----
R
K
----
E
GDT
G
G
---
T
I
S
V
-
A
P
N
F
A
F
D
H
A
A
A
R
-
G
V
-
P
K
P
G
S
P
P
L
D
L
S
N
V
K
A
V
L
N
G
S
E
P
I
S
A
A
T
V
R
R
F
N
E
A
F
G
P
F
G
F
P
P
K
A
I
K
P
S
Y
G
L
A
E
A
T
L
F
V
S
T
T
P
S
A
E
E
P
K
I
I
T
V
D
R
D
Q
L
N
S
G
--
R
I
V
E
V
D
ADSPK
A
V
-
A
Q
--
A
S
A
--
G
K
V
G
I
A
E
W
-
A
------
V
-----------
I
V
D
A
E
S
A
T
E
L
P
D
G
Q
V
G
E
I
W
I
S
G
Q
N
M
G
T
G
Y
W
G
K
P
E
E
S
V
A
T
F
Q
N
I
L
------
K
S
R
T
N
P
-----
S
H
------
A
-
E
G
A
TDD
A
T
W
V
R
T
G
D
Y
G
A
F
Y
-
D
G
D
L
Y
I
T
G
R
V
K
D
L
V
I
I
D
G
R
N
---
H
Y
P
Q
D
L
E
Y
S
A
Q
----
E
----
A
-
S
----
K
AIRT
G
---
Y
V
A
A
F
S
V
P
A
NQLP
D
E
V
F
E
NAHSGIKRDP
D
D
-------------------
T
S
E
Q
L
V
----
I
------------------
V
A
E
-
R
A
--------
D
----
I
G
P
----------
I
T
D
D
I
R
A
A
I
A
V
R
H
G
V
T
V
R
D
V
L
L
T
A
A
G
A
I
P
R
T
S
S
G
K
I
G
R
R
A
C
R
A
A
Y
---------------
3
PsiBlast_PDB
78.03
36%
-97
- C5 -
5D6J
2
?
A:
[20-611]
-----------------
S
I
V
A
H
V
E
R
W
A
K
V
R
G
D
K
L
A
Y
R
F
L
D
F
S
T
E
R
D
G
V
P
R
D
L
T
W
A
Q
F
S
A
R
N
R
A
V
A
A
R
------
L
Q
Q
V
-
T
-
Q
P
-
G
D
R
V
A
I
L
C
P
Q
N
L
D
Y
L
V
A
F
F
G
A
L
Y
A
G
R
I
A
V
P
L
F
D
-
P
S
E
-
P
G
H
V
---
G
R
L
---
H
A
V
L
D
N
C
H
P
S
A
I
L
T
T
T
E
A
A
E
G
V
R
K
F
F
R
T
R
P
A
N
Q
R
P
R
V
----
I
A
V
D
------------
A
V
P
D
D
-
V
A
S
------
T
W
V
-
N
P
D
E
P
D
E
-----
T
-
T
I
A
Y
L
Q
Y
T
S
G
S
T
R
I
P
T
G
V
Q
I
T
H
L
N
L
-
A
T
N
V
V
Q
V
I
E
A
L
E
G
E
E
-------
G
D
R
G
L
S
W
L
P
F
F
H
D
M
G
L
I
-
T
A
L
L
A
P
M
I
G
----
H
Y
F
T
F
M
T
-
P
A
A
F
V
R
R
P
E
R
W
I
R
E
L
A
----
R
K
----
E
GDT
G
G
---
T
I
S
V
-
A
P
N
F
A
F
D
H
A
A
A
R
-
G
V
-
P
K
P
G
S
P
P
L
D
L
S
N
V
K
A
V
L
N
G
S
E
P
I
S
A
A
T
V
R
R
F
N
E
A
F
G
P
F
G
F
P
P
K
A
I
K
P
S
Y
G
L
A
E
A
T
L
F
V
S
T
T
P
S
A
E
E
P
K
I
I
T
V
D
R
D
Q
L
N
S
G
--
R
I
V
E
V
D
ADSPK
A
V
-
A
Q
--
A
S
A
--
G
K
V
G
I
A
E
W
-
A
------
V
-----------
I
V
D
A
E
S
A
T
E
L
P
D
G
Q
V
G
E
I
W
I
S
G
Q
N
M
G
T
G
Y
W
G
K
P
E
E
S
V
A
T
F
Q
N
I
L
------
K
S
R
T
N
P
-----
S
H
------
A
-
E
G
A
TDD
A
T
W
V
R
T
G
D
Y
G
A
F
Y
-
D
G
D
L
Y
I
T
G
R
V
K
D
L
V
I
I
D
G
R
N
---
H
Y
P
Q
D
L
E
Y
S
A
Q
----
E
----
A
-
S
----
K
AIRT
G
---
Y
V
A
A
F
S
V
P
A
NQLP
D
E
V
F
E
NAHSG
I
K
R
D
P
D
D
-------------------
T
S
E
Q
L
V
----
I
------------------
V
A
E
-
R
A
P
G
A
H
K
--
L
D
----
I
G
P
----------
I
T
D
D
I
R
A
A
I
A
V
R
H
G
V
T
V
R
D
V
L
L
T
A
A
G
A
I
P
R
T
S
S
G
K
I
G
R
R
A
C
R
A
A
Y
---------------
25
PsiBlast_CBE
77.83
36%
-94
- C5 -
5EY8
1
?
B:
[20-611]
-----------------
S
I
V
A
H
V
E
R
W
A
K
V
R
G
D
K
L
A
Y
R
F
L
D
F
S
T
---
G
V
P
R
D
L
T
W
A
Q
F
S
A
R
N
R
A
V
A
A
R
------
L
Q
Q
V
-
T
-
Q
P
-
G
D
R
V
A
I
L
C
P
Q
N
L
D
Y
L
V
A
F
F
G
A
L
Y
A
G
R
I
A
V
P
L
F
D
-
P
S
---
G
H
V
---
G
R
L
---
H
A
V
L
D
N
C
H
P
S
A
I
L
T
T
T
E
A
A
E
G
V
R
K
F
F
R
T
R
P
A
N
Q
R
P
R
V
----
I
A
V
D
------------
A
V
P
D
D
-
V
A
S
------
T
W
V
-
N
P
D
E
P
D
E
-----
T
-
T
I
A
Y
L
Q
Y
T
S
G
S
T
R
I
P
T
G
V
Q
I
T
H
L
N
L
-
A
T
N
V
V
Q
V
I
E
A
L
E
G
E
E
-------
G
D
R
G
L
S
W
L
P
F
F
H
D
M
G
L
I
-
T
A
L
L
A
P
M
I
G
----
H
Y
F
T
F
M
T
-
P
A
A
F
V
R
R
P
E
R
W
I
R
E
L
A
----
R
K
----
E
GDT
G
G
---
T
I
S
V
-
A
P
N
F
A
F
D
H
A
A
A
R
-
G
V
-
P
K
P
G
S
P
P
L
D
L
S
N
V
K
A
V
L
N
G
S
E
P
I
S
A
A
T
V
R
R
F
N
E
A
F
G
P
F
G
F
P
P
K
A
I
K
P
S
Y
G
L
A
E
A
T
L
F
V
S
T
T
P
S
A
E
E
P
K
I
I
T
V
D
R
D
Q
L
N
S
G
--
R
I
V
E
V
D
ADSPK
A
V
-
A
Q
--
A
S
A
--
G
K
V
G
I
A
E
W
-
A
------
V
-----------
I
V
D
A
E
S
A
T
E
L
P
D
G
Q
V
G
E
I
W
I
S
G
Q
N
M
G
T
G
Y
W
G
K
P
E
E
S
V
A
T
F
Q
N
I
L
------
K
S
R
T
N
P
-----
S
H
------
A
-
E
G
A
TDD
A
T
W
V
R
T
G
D
Y
G
A
F
Y
-
D
G
D
L
Y
I
T
G
R
V
K
D
L
V
I
I
D
G
R
N
---
H
Y
P
Q
D
L
E
Y
S
A
Q
----
E
----
A
-
S
----
K
AIRT
G
---
Y
V
A
A
F
S
V
P
A
NQLP
D
E
V
F
E
NAHSGIKRDP
D
D
-------------------
T
S
-
Q
L
V
----
I
------------------
V
A
E
-
R
--------
L
D
----
I
G
P
----------
I
T
D
D
I
R
A
A
I
A
V
R
H
G
V
T
V
R
D
V
L
L
T
A
A
G
A
I
P
R
T
S
S
G
K
I
G
R
R
A
C
R
A
A
Y
---------------
21
PsiBlast_CBE
77.58
36%
-94
- C5 -
5EY8
1
?
H:
[20-611]
-----------------
S
I
V
A
H
V
E
R
W
A
K
V
R
G
D
K
-
A
Y
R
F
L
D
F
S
T
E
R
D
G
V
P
R
D
L
T
W
A
Q
F
S
A
R
N
R
A
V
A
A
R
------
L
Q
Q
V
-
T
-
Q
P
-
G
D
R
V
A
I
L
C
P
Q
N
L
D
Y
L
V
A
F
F
G
A
L
Y
A
G
R
I
A
V
P
L
F
D
-
P
S
E
---
H
V
---
G
R
L
---
H
A
V
L
D
N
C
H
P
S
A
I
L
T
T
T
E
A
A
E
G
V
R
K
F
F
R
T
R
P
A
N
Q
R
P
R
V
----
I
A
V
D
------------
A
V
P
D
D
-
V
A
S
------
T
W
V
-
N
P
D
E
P
D
E
-----
T
-
T
I
A
Y
L
Q
Y
T
S
G
--
R
I
P
T
G
V
Q
I
T
H
L
N
L
-
A
T
N
V
V
Q
V
I
E
A
L
E
G
E
E
-------
G
D
R
G
L
S
W
L
P
F
F
H
D
M
G
L
I
-
T
A
L
L
--
M
I
G
----
H
Y
F
T
F
M
T
-
P
A
A
F
V
R
R
P
E
R
W
I
R
E
L
A
----
R
K
----
E
GDT-----
T
I
S
V
-
A
P
N
F
A
F
D
H
A
A
A
R
-
G
V
-
P
K
P
G
S
P
P
L
D
L
S
N
V
K
A
V
L
N
G
S
E
P
I
S
A
A
T
V
R
R
F
N
E
A
F
G
P
F
G
F
P
P
K
A
I
K
P
S
Y
G
L
A
E
A
T
L
F
V
S
T
T
P
S
A
E
E
P
K
I
I
T
V
D
R
D
Q
L
N
S
G
--
R
I
V
E
V
D
ADSP
K
A
V
-
A
Q
--
A
S
A
--
G
K
V
G
I
A
E
W
-
A
------
V
-----------
I
V
D
A
E
S
A
T
E
L
P
D
G
Q
V
G
E
I
W
I
S
G
Q
N
M
G
T
G
Y
W
G
K
P
E
E
S
V
A
T
F
Q
N
I
L
------
K
S
R
T
N
P
-----
S
H
------
A
-
E
G
A
TDD
A
T
W
V
R
T
G
D
Y
G
A
F
Y
-
D
G
D
L
Y
I
T
G
R
V
K
D
L
V
I
I
D
G
R
N
---
H
Y
P
Q
D
L
E
Y
S
A
Q
----
E
----
A
-
S
----
K
AIRT
G
---
Y
V
A
A
F
S
V
P
A
NQLP
D
E
V
F
E
NAHSGIKRDP
D
D
-------------------
T
S
E
Q
L
V
----
I
------------------
V
A
E
-
R
A
--
A
H
K
--
L
D
----
I
G
P
----------
I
T
D
D
I
R
A
A
I
A
V
R
H
G
V
T
V
R
D
V
L
L
T
A
A
G
A
I
P
R
T
S
S
G
K
I
G
R
R
A
C
R
A
A
Y
---------------
2
PsiBlast_PDB
77.49
36%
-94
- C5 -
5EY8
1
?
A:
[20-611]
-----------------
S
I
V
A
H
V
E
R
W
A
K
V
R
G
D
K
L
A
Y
R
F
L
D
F
S
T
E
R
D
G
V
P
R
D
L
T
W
A
Q
F
S
A
R
N
R
A
V
A
A
R
------
L
Q
Q
V
-
T
-
Q
P
-
G
D
R
V
A
I
L
C
P
Q
N
L
D
Y
L
V
A
F
F
G
A
L
Y
A
G
R
I
A
V
P
L
F
D
-
P
S
E
-
P
G
H
V
---
G
R
L
---
H
A
V
L
D
N
C
H
P
S
A
I
L
T
T
T
E
A
A
E
G
V
R
K
F
F
R
T
R
P
A
N
Q
R
P
R
V
----
I
A
V
D
------------
A
V
P
D
D
-
V
A
S
------
T
W
V
-
N
P
D
E
P
D
E
-----
T
-
T
I
A
Y
L
Q
Y
T
S
---
R
I
P
T
G
V
Q
I
T
H
L
N
L
-
A
T
N
V
V
Q
V
I
E
A
L
E
G
E
E
-------
G
D
R
G
L
S
W
L
P
F
F
H
D
M
G
L
I
-
T
A
L
L
A
P
M
I
G
----
H
Y
F
T
F
M
T
-
P
A
A
F
V
R
R
P
E
R
W
I
R
E
L
A
----
R
K
----
E
GDT
G
G
---
T
I
S
V
-
A
P
N
F
A
F
D
H
A
A
A
R
-
G
V
-
P
K
P
G
S
P
P
L
D
L
S
N
V
K
A
V
L
N
G
S
E
P
I
S
A
A
T
V
R
R
F
N
E
A
F
G
P
F
G
F
P
P
K
A
I
K
P
S
Y
G
L
A
E
A
T
L
F
V
S
T
T
P
S
A
E
E
P
K
I
I
T
V
D
R
D
Q
L
N
S
G
--
R
I
V
E
V
D
ADSPK
A
V
-
A
Q
--
A
S
A
--
G
K
V
G
I
A
E
W
-
A
------
V
-----------
I
V
D
A
E
S
A
T
E
L
P
D
G
Q
V
G
E
I
W
I
S
G
Q
N
M
G
T
G
Y
W
G
K
P
E
E
S
V
A
T
F
Q
N
I
L
------
K
S
R
T
N
P
-----
S
H
------
A
-
E
G
A
TDD
A
T
W
V
R
T
G
D
Y
G
A
F
Y
-
D
G
D
L
Y
I
T
G
R
V
K
D
L
V
I
I
D
G
R
N
---
H
Y
P
Q
D
L
E
Y
S
A
Q
----
E
----
A
-
S
----
K
AIRT
G
---
Y
V
A
A
F
S
V
P
A
NQLP
D
E
V
F
E
NAHSG
I
K
R
D
P
D
D
-------------------
T
S
E
Q
L
V
----
I
------------------
V
A
E
-
R
A
P
-------
D
----
I
G
P
----------
I
T
D
D
I
R
A
A
I
A
V
R
H
G
V
T
V
R
D
V
L
L
T
A
A
G
A
I
P
R
T
S
S
G
K
I
G
R
R
A
C
R
A
A
Y
---------------
4
PsiBlast_PDB
77.23
36%
-93
- C5 -
5ICR
3
?
A:
[40-631]
-----------------
S
I
V
A
H
V
E
R
W
A
K
V
R
G
D
K
L
A
Y
R
F
L
D
F
S
T
E
R
D
G
V
P
R
D
L
T
W
A
Q
F
S
A
R
N
R
A
V
A
A
R
------
L
Q
Q
V
-
T
-
Q
P
-
G
D
R
V
A
I
L
C
P
Q
N
L
D
Y
L
V
A
F
F
G
A
L
Y
A
G
R
I
A
V
P
L
F
D
-
P
S
E
-
P
G
H
V
---
G
R
L
---
H
A
V
L
D
N
C
H
P
S
A
I
L
T
T
T
E
A
A
E
G
V
R
K
F
F
R
T
R
P
A
N
Q
R
P
R
V
----
I
A
V
D
------------
A
V
P
D
D
-
V
A
S
------
T
W
V
-
N
P
D
E
P
D
E
-----
T
-
T
I
A
Y
L
Q
Y
T
S
---
R
I
P
T
G
V
Q
I
T
H
L
N
L
-
A
T
N
V
V
Q
V
I
E
A
L
E
G
E
E
-------
G
D
R
G
L
S
W
L
P
F
F
H
D
M
G
L
I
-
T
A
L
L
A
P
M
I
G
----
H
Y
F
T
F
M
T
-
P
A
A
F
V
R
R
P
E
R
W
I
R
E
L
A
----
R
K
----
E
GDT
G
G
---
T
I
S
V
-
A
P
N
F
A
F
D
H
A
A
A
R
-
G
V
-
P
K
P
G
S
P
P
L
D
L
S
N
V
K
A
V
L
N
G
S
E
P
I
S
A
A
T
V
R
R
F
N
E
A
F
G
P
F
G
F
P
P
K
A
I
K
P
S
Y
G
L
A
E
A
T
L
F
V
S
T
T
P
S
A
E
E
P
K
I
I
T
V
D
R
D
Q
L
N
S
G
--
R
I
V
E
V
D
ADSPK
A
V
-
A
Q
--
A
S
A
--
G
K
V
G
I
A
E
W
-
A
------
V
-----------
I
V
D
A
E
S
A
T
E
L
P
D
G
Q
V
G
E
I
W
I
S
G
Q
N
M
G
T
G
Y
W
G
K
P
E
E
S
V
A
T
F
Q
N
I
L
------
K
S
R
T
N
P
-----
S
H
------
A
-
E
G
A
TDD
A
T
W
V
R
T
G
D
Y
G
A
F
Y
-
D
G
D
L
Y
I
T
G
R
V
K
D
L
V
I
I
D
G
R
N
---
H
Y
P
Q
D
L
E
Y
S
A
Q
----
E
----
A
-
S
----
K
AIRT
G
---
Y
V
A
A
F
S
V
P
A
NQLPDEDP-----------
D
D
-------------------
T
S
E
Q
L
V
----
I
------------------
V
A
E
-
R
A
P
---
K
--
L
D
----
I
G
P
----------
I
T
D
D
I
R
A
A
I
A
V
R
H
G
V
T
V
R
D
V
L
L
T
A
A
G
A
I
P
R
T
S
S
G
K
I
G
R
R
A
C
R
A
A
Y
---------------
7
PsiBlast_PDB
76.76
32%
-92
- C5 -
3LNV
2
?
A:
[8-563]
--------
L
Q
C
Q
-----
S
L
V
D
V
V
R
L
R
A
L
H
S
P
N
K
K
S
C
T
F
L
N
K
E
-----
L
E
E
T
M
T
Y
E
Q
L
D
Q
H
A
K
A
I
A
A
T
------
L
Q
A
E
-
G
-
A
K
P
G
D
R
V
L
L
L
F
A
P
G
L
P
L
I
Q
A
F
L
G
C
L
Y
A
G
C
I
A
V
P
I
Y
P
-
P
A
Q
-
E
K
L
L
---
D
K
A
---
Q
R
I
V
T
N
S
K
P
V
I
V
L
M
I
A
---
D
H
I
K
K
F
T
-------
P
K
F
L
K
I
P
A
I
A
L
E
------------
S
I
E
L
N
-
R
S
S
------
S
W
Q
-
P
T
S
I
K
S
N
-----
D
-
I
-
A
F
L
Q
Y
T
S
G
S
T
M
H
P
K
G
V
M
V
S
H
H
N
L
-
L
D
N
L
N
K
I
F
T
S
F
H
M
N
D
E
T
I
-------
I
F
S
W
L
P
P
H
H
D
M
G
L
I
-
G
C
I
L
T
P
I
Y
G
----
G
I
Q
A
I
M
M
S
P
F
S
F
L
Q
N
P
L
S
W
L
K
H
I
T
----
K
Y
----
K
----
A
---
T
I
S
G
-
S
P
N
F
A
Y
D
Y
C
V
K
R
-
I
R
-
E
E
K
K
E
-
G
L
D
L
S
S
W
V
T
A
F
N
G
A
E
P
V
R
E
E
T
M
E
H
F
Y
Q
A
F
K
E
F
G
F
R
K
E
A
F
Y
P
C
Y
G
L
A
E
A
T
L
L
V
T
G
G
T
P
G
S
S
Y
K
T
L
T
L
A
K
E
Q
F
Q
D
H
R
V
H
----------
F
A
-
D
D
---
S
P
--
G
S
Y
K
L
V
S
S
-
G
------
N
P
-
I
Q
E
----
V
K
I
I
D
P
D
T
L
I
P
C
D
F
D
Q
V
G
E
I
W
V
Q
S
N
S
V
A
K
G
Y
W
N
Q
P
E
E
T
R
H
A
F
A
G
K
I
----------
K
D
-----
D
---------
S
A
I
-----
Y
L
R
T
G
D
L
G
F
L
H
-
E
N
E
L
Y
V
T
G
R
I
K
D
L
I
I
I
Y
G
K
N
---
H
Y
P
Q
D
I
E
F
S
L
M
H
SPL
H
----
H
-
V
----
L
----
G
---
K
C
A
A
F
V
I
Q
E
-------------------
E
H
-------------------
E
Y
-
K
L
T
----
V
------------------
M
C
E
V
K
N
R
F
M
D
D
V
A
Q
D
N
L
F
----------------
N
E
I
F
E
L
V
Y
E
N
H
Q
L
E
V
H
T
I
V
L
I
P
L
K
A
M
P
H
--
S
G
K
I
R
R
N
F
C
-------------------
22
PsiBlast_CBE
76.75
36%
-94
- C5 -
5EY8
2
?
F:
[20-611]
-----------------
S
I
V
A
H
V
E
R
W
A
K
V
R
G
D
K
L
A
Y
R
F
L
D
F
S
T
E
R
D
G
V
P
R
D
L
T
W
A
Q
F
S
A
R
N
R
A
V
A
A
R
------
L
Q
Q
V
-
T
-
Q
P
-
G
D
R
V
A
I
L
C
P
Q
N
L
D
Y
L
V
A
F
F
G
A
L
Y
A
G
R
I
A
V
P
L
F
D
-
P
S
E
-
P
G
H
V
---
G
R
L
---
H
A
V
L
D
N
C
H
P
S
A
I
L
T
T
T
E
A
A
E
G
V
R
K
F
F
R
T
R
P
A
N
Q
R
P
R
V
----
I
A
V
D
------------
A
V
P
D
D
-
V
A
S
------
T
W
V
-
N
P
D
E
P
D
E
-----
T
-
T
I
A
Y
L
Q
Y
T
S
---
R
I
P
T
G
V
Q
I
T
H
L
N
L
-
A
T
N
V
V
Q
V
I
E
A
L
E
G
E
E
-------
G
D
R
G
L
S
W
L
P
F
F
H
D
M
G
L
I
-
T
A
L
L
A
P
M
I
G
----
H
Y
F
T
F
M
T
-
P
A
A
F
V
R
R
P
E
R
W
I
R
E
L
A
----
R
K
----
E
GDT
G
G
---
T
I
S
V
-
A
P
N
F
A
F
D
H
A
A
A
R
-
G
V
-
P
K
P
G
S
P
P
L
D
L
S
N
V
K
A
V
L
N
G
S
E
P
I
S
A
A
T
V
R
R
F
N
E
A
F
G
P
F
G
F
P
P
K
A
I
K
P
S
Y
G
L
A
E
A
T
L
F
V
S
T
T
P
S
A
E
E
P
K
I
I
T
V
D
R
D
Q
L
N
S
G
--
R
I
V
E
V
D
ADSPK
A
V
-
A
Q
--
A
S
A
--
G
K
V
G
I
A
E
W
-
A
------
V
-----------
I
V
D
A
E
S
A
T
E
L
P
D
G
Q
V
G
E
I
W
I
S
G
Q
N
M
G
T
G
Y
W
G
K
P
E
E
S
V
A
T
F
Q
N
I
L
------
K
S
R
T
N
P
-----
S
H
------
A
-
E
G
A
TDD
A
T
W
V
R
T
G
D
Y
G
A
F
Y
-
D
G
D
L
Y
I
T
G
R
V
K
D
L
V
I
I
D
G
R
N
---
H
Y
P
Q
D
L
E
Y
S
A
Q
----
E
----
A
-
S
----
K
AIRT
G
---
Y
V
A
A
F
S
V
P
A
NQLP
D
E
V
F
E
NAHSGIKRDP
D
D
-------------------
T
S
E
Q
L
V
----
I
------------------
V
A
E
-
R
A
P
-------
D
----
I
G
P
----------
I
T
D
D
I
R
A
A
I
A
V
R
H
G
V
T
V
R
D
V
L
L
T
A
A
G
A
I
P
R
T
S
S
G
K
I
G
R
R
A
C
R
A
A
Y
---------------
6
PsiBlast_PDB
76.54
32%
-91
- C5 -
3KXW
1
?
A:
[8-561]
--------
L
Q
C
Q
-----
S
L
V
D
V
V
R
L
R
A
L
H
S
P
N
K
K
S
C
T
F
L
N
K
E
-----
L
E
E
T
M
T
Y
E
Q
L
D
Q
H
A
K
A
I
A
A
T
------
L
Q
A
E
-
G
-
A
K
P
G
D
R
V
L
L
L
F
A
P
G
L
P
L
I
Q
A
F
L
G
C
L
Y
A
G
C
I
A
V
P
I
Y
P
-
P
A
Q
-
E
K
L
L
---
D
K
A
---
Q
R
I
V
T
N
S
K
P
V
I
V
L
M
I
A
---
D
H
I
K
K
F
T
A
-----
N
P
K
F
L
K
I
P
A
I
A
L
E
------------
S
I
E
L
N
-
R
S
S
------
S
W
Q
-
P
T
S
I
K
S
N
-----
D
-
I
-
A
F
L
Q
Y
T
S
G
S
T
M
H
P
K
G
V
M
V
S
H
H
N
L
-
L
D
N
L
N
K
I
F
T
S
F
H
M
N
D
E
T
I
-------
I
F
S
W
L
P
P
H
H
D
M
G
L
I
-
G
C
I
L
T
P
I
Y
G
----
G
I
Q
A
I
M
M
S
P
F
S
F
L
Q
N
P
L
S
W
L
K
H
I
T
----
K
Y
----
K
----
A
---
T
I
S
G
-
S
P
N
F
A
Y
D
Y
C
V
K
R
-
I
R
-
E
E
K
K
E
-
G
L
D
L
S
S
W
V
T
A
F
N
G
A
E
P
V
R
E
E
T
M
E
H
F
Y
Q
A
F
K
E
F
G
F
R
K
E
A
F
Y
P
C
Y
G
L
A
E
A
T
L
L
V
T
G
G
T
P
G
S
S
Y
K
T
L
T
L
A
K
E
Q
F
Q
D
H
R
V
H
----------
F
A
-
D
D
--
N
S
P
--
G
S
Y
K
L
V
S
S
-
G
------
N
P
-
I
Q
E
----
V
K
I
I
D
P
D
T
L
I
P
C
D
F
D
Q
V
G
E
I
W
V
Q
S
N
S
V
A
K
G
Y
W
N
Q
P
E
E
T
R
H
A
F
A
G
K
I
----------
K
D
-----
D
----------
A
I
-----
Y
L
R
T
G
D
L
G
F
L
H
-
E
N
E
L
Y
V
T
G
R
I
K
D
L
I
I
I
Y
G
K
N
---
H
Y
P
Q
D
I
E
F
S
L
M
H
SPL
H
----
H
-
V
----
L
----
G
---
K
C
A
A
F
V
I
Q
E
-------------------
E
H
-------------------
E
Y
-
K
L
T
----
V
------------------
M
C
E
V
K
N
R
F
M
D
D
V
A
Q
D
N
L
F
----------------
N
E
I
F
E
L
V
Y
E
N
H
Q
L
E
V
H
T
I
V
L
I
P
L
K
A
M
P
H
T
T
S
G
K
I
R
R
N
F
C
-------------------
8
PsiBlast_PDB
70.86
37%
-99
- C5 -
5D6N
-
?
A:
[20-482]
-----------------
S
I
V
A
H
V
E
R
W
A
K
V
R
G
D
K
L
A
Y
R
F
L
D
F
S
T
E
R
D
G
V
P
R
D
L
T
W
A
Q
F
S
A
R
N
R
A
V
A
A
R
------
L
Q
Q
V
-
T
-
Q
P
-
G
D
R
V
A
I
L
C
P
Q
N
L
D
Y
L
V
A
F
F
G
A
L
Y
A
G
R
I
A
V
P
L
F
D
-
P
S
E
-
P
G
H
V
---
G
R
L
---
H
A
V
L
D
N
C
H
P
S
A
I
L
T
T
T
E
A
A
E
G
V
R
K
F
F
R
T
R
P
A
N
Q
R
P
R
V
----
I
A
V
D
------------
A
V
P
D
D
-
V
A
S
------
T
W
V
-
N
P
D
E
P
D
E
-----
T
-
T
I
A
Y
L
Q
Y
T
S
G
S
T
R
I
P
T
G
V
Q
I
T
H
L
N
L
-
A
T
N
V
V
Q
V
I
E
A
L
E
G
E
E
-------
G
D
R
G
L
S
W
L
P
F
F
H
D
M
G
L
I
-
T
A
L
L
A
P
M
I
G
----
H
Y
F
T
F
M
T
-
P
A
A
F
V
R
R
P
E
R
W
I
R
E
L
A
----
R
K
----
E
GDT
G
G
---
T
I
S
V
-
A
P
N
F
A
F
D
H
A
A
A
R
-
G
V
-
P
K
P
G
S
P
P
L
D
L
S
N
V
K
A
V
L
N
G
S
E
P
I
S
A
A
T
V
R
R
F
N
E
A
F
G
P
F
G
F
P
P
K
A
I
K
P
S
Y
G
L
A
E
A
T
L
F
V
S
T
T
P
S
A
E
E
P
K
I
I
T
V
D
R
D
Q
L
N
S
G
--
R
I
V
E
V
D
ADSPK
A
V
-
A
Q
--
A
S
A
--
G
K
V
G
I
A
E
W
-
A
------
V
-----------
I
V
D
A
E
S
A
T
E
L
P
D
G
Q
V
G
E
I
W
I
S
G
Q
N
M
G
T
G
Y
W
G
K
P
E
E
S
V
A
T
F
Q
N
I
L
------
K
S
R
T
N
P
-----
S
H
------
A
-
E
G
A
TDD
A
T
W
V
R
T
G
D
Y
G
A
F
Y
-
D
G
D
L
Y
I
T
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
70.34
30%
-78
- C5 -
3PBK
1
?
A:
[48-567]
-------------------------------------------------------
Q
L
E
Y
Q
T
L
K
A
R
A
E
A
G
A
K
R
L
L
S
L
N
-
L
-
K
K
-
G
D
R
V
A
L
I
A
E
T
S
S
E
F
V
E
A
F
F
A
C
Q
Y
A
G
L
V
A
V
P
L
A
I
-
P
M
G
V
G
Q
R
D
---
S
W
S
A
K
L
Q
G
L
L
A
S
C
Q
P
A
A
I
I
T
G
----
D
E
W
L
P
L
V
N
A
A
T
H
D
N
P
E
L
H
----
V
L
S
H
------------
A
W
F
K
A
-
L
P
E
------
A
D
V
-
A
L
Q
R
P
V
P
-----
N
D
I
-
A
Y
L
Q
Y
T
S
G
S
T
R
F
P
R
G
V
I
I
T
H
R
E
V
-
M
A
N
L
R
A
I
------
S
H
D
G
I
K
L
R
P
G
D
R
C
V
S
W
L
P
F
Y
H
D
M
G
L
V
-
G
F
L
L
T
P
V
A
T
----
Q
L
S
V
D
Y
L
R
T
Q
D
F
A
M
R
P
L
Q
W
L
K
L
I
S
----
K
N
----
R
----
G
---
T
V
S
V
-
A
P
P
F
G
Y
E
L
C
Q
R
R
-
V
N
-
E
K
D
L
A
-
E
L
D
L
S
C
W
R
V
A
G
I
G
A
E
P
I
S
A
E
Q
L
H
Q
F
A
E
C
F
R
Q
V
N
F
D
N
K
T
F
M
P
C
Y
G
L
A
E
N
A
L
A
V
S
F
S
D
E
A
S
G
V
V
V
N
E
V
D
R
D
I
L
E
Y
---
Q
----------
G
K
-
A
V
--
A
P
G
--
A
E
T
R
A
V
S
T
-
F
V
N
CGKA
L
P
-
E
H
G
I
---
E
--
I
R
N
E
A
G
M
P
V
A
E
R
V
V
G
H
I
C
I
S
G
P
S
L
M
S
G
Y
F
-----------
G
D
Q
------
V
S
-
Q
D
E
-----
I
A
------
A
-
T
G
------
W
L
D
T
G
D
L
G
Y
L
L
-
D
G
Y
L
Y
V
T
G
R
I
K
D
L
I
I
I
R
G
R
N
---
I
W
P
Q
D
I
E
Y
I
A
E
QEP-
E
----
I
-
H
----
S
----
G
---
D
A
I
A
F
V
T
------------------------------------------
A
Q
E
K
I
I
----
L
------------------
Q
I
Q
C
R
I
---
S
D
--
E
E
---
R
R
G
Q
----------
L
I
H
A
L
A
A
R
I
Q
S
E
F
G
V
T
A
A
-
I
D
L
L
P
P
H
S
I
P
R
T
S
S
G
K
P
A
R
A
E
A
K
K
R
Y
-----
Q
K
A
Y
A
A
S
---
10
PsiBlast_PDB
66.36
22%
-72
- C5 -
4R0M
1
?
B:
[17-549]
-----------
R
-----
T
L
S
E
V
L
E
T
A
T
K
H
N
N
H
G
I
T
Y
I
R
N
D
A
T
E
Y
F
Q
------
S
Y
Q
D
L
Y
Q
D
A
L
V
I
L
N
G
------
L
E
Q
K
-
G
I
K
L
-
G
H
K
V
I
L
Q
I
A
K
N
Q
D
F
I
P
A
L
W
A
C
F
L
G
G
I
I
P
V
P
L
T
V
A
P
S
Y
-
D
L
E
N
S
A
V
K
K
L
---
E
N
V
W
K
I
L
D
N
P
L
I
L
S
D
S
E
L
I
T
E
I
-
E
K
L
G
T
Y
S
H
L
E
G
W
Q
V
----
I
S
V
N
------------
E
L
R
-
K
-
A
P
S
-----------
K
I
E
Q
L
P
I
L
D
PQ
D
-
A
-
A
L
L
L
F
T
S
G
S
T
G
M
P
K
G
V
I
L
T
H
H
N
I
L
S
M
T
A
G
T
V
V
M
N
H
F
T
Q
Q
E
--------
V
T
L
N
W
M
P
L
D
H
V
G
A
I
V
F
L
G
I
M
A
V
D
L
A
C
D
Q
I
H
V
P
M
E
L
V
-----
L
R
Q
P
L
Q
W
L
E
L
I
Q
----
K
H
----
Q
----
V
---
S
I
S
W
-
S
P
N
F
A
F
S
L
I
N
Q
Q
-
A
E
-
E
L
K
H
V
-
S
Y
N
L
S
S
M
K
F
L
V
N
A
G
E
Q
V
S
V
K
T
I
R
L
F
L
E
I
L
E
K
H
Q
L
Q
E
R
A
I
K
P
A
F
G
M
T
E
S
C
S
G
I
T
W
S
-
A
G
L
S
K
N
E
L
T
E
E
N
S
F
V
S
L
G
--
K
----------
P
I
-
P
--------
G
A
T
-----------------------
I
R
I
V
D
Q
E
N
N
-
P
L
P
E
R
E
I
G
R
L
Q
I
Q
G
N
S
V
T
K
G
Y
Y
N
N
N
E
L
N
Q
E
V
F
-----------------------------
Q
-
E
G
------
W
F
T
T
G
D
L
G
Y
L
S
-
K
G
E
L
F
I
T
G
R
E
K
Q
E
I
I
I
N
G
V
N
Y
F
A
H
E
L
E
T
T
I
E
E
L
E
----
G
----
V
-
K
----
V
----
S
---
Y
T
A
A
F
A
V
-
F
-------------------
D
Q
-------------------
S
R
E
T
D
L
----
L
------------------
I
I
T
F
S
P
E
S
E
Q
F
--
E
Q
G
I
----
K
----------
V
V
R
K
I
R
S
H
V
T
Q
K
F
G
I
A
P
A
Y
V
I
P
L
E
R
N
L
V
P
K
T
S
I
G
K
V
Q
K
S
K
L
K
K
D
F
-----
E
Q
G
L
F
S
----
49
HHSearch
61.23
19%
-74
* C5 *
2D1S
3
LUCI_LUCCR
A:
[22-544]
----------
E
G
-----
S
A
G
T
Q
L
R
K
Y
M
E
R
Y
A
K
L
G
A
I
A
F
T
N
A
V
-----
T
G
V
D
Y
S
Y
A
E
Y
L
E
K
S
C
C
L
G
K
A
------
L
Q
N
Y
G
L
-
V
V
-
D
G
R
I
A
L
C
S
E
N
C
E
E
F
F
I
P
V
I
A
G
L
F
I
G
V
G
V
A
P
T
N
E
-
I
Y
T
----
L
---
R
E
L
---
V
H
S
L
G
I
S
K
P
T
I
V
F
S
S
K
K
G
L
D
K
V
I
T
V
Q
K
T
V
T
--
T
I
K
T
I
----
V
I
L
D
SKVDYRGYQ
C
L
D
T
F
I
K
R
N
T
P
P
GFQAS
S
F
K
T
-
V
E
V
D
R
K
E
-----
Q
-
V
-
A
L
I
M
N
S
S
G
S
T
G
L
P
K
G
V
Q
L
T
H
E
N
I
-
V
T
R
F
S
H
A
R
D
P
I
Y
---
G
N
Q
V
-
S
P
G
T
A
V
L
T
V
V
P
F
H
H
G
F
G
M
F
-
T
-
T
L
G
Y
L
I
C
----
G
F
R
V
V
M
L
T
K
F
----
D
E
E
T
F
L
K
T
L
Q
----
D
Y
----
K
----
C
---
T
S
V
I
L
V
P
T
L
F
A
I
L
N
-
K
S
-
E
L
----
L
N
-
K
Y
D
L
S
N
L
V
E
I
A
S
G
G
A
P
L
S
K
E
V
G
E
A
V
A
R
R
F
N
L
-----
P
G
V
R
Q
G
Y
G
L
T
E
T
T
S
A
I
I
I
T
P
E
G
D
------------------------------------------
D
K
P
G
A
S
-
G
------
K
V
V
P
L
F
K
---
A
K
V
I
D
L
D
T
K
K
S
L
G
P
N
R
R
G
E
V
C
V
K
G
P
M
L
M
K
G
Y
V
N
N
P
E
A
T
K
E
L
I
D
------------------------------
E
E
G
-----
W
L
H
T
G
D
I
G
Y
Y
D
E
E
K
H
F
F
I
V
D
R
L
K
S
L
I
K
Y
K
G
Y
Q
---
V
P
P
A
E
L
E
S
V
L
L
----
Q
----
H
P
S
----
I
----
F
---
D
A
G
V
A
G
V
P
D
-------------------
P
V
-------------------
A
G
E
L
P
G
----
A
------------------
V
V
V
L
E
S
G
K
N
--------
M
T
E
K
E
----------
V
M
D
Y
V
A
S
Q
V
S
N
A
K
R
L
R
G
-
G
V
--
R
F
V
D
E
V
P
K
G
L
T
G
K
I
D
G
R
A
I
R
E
I
L
-----
K
K
P
-------