@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv3084: (2016-05-16 )
MNLRKNVIRSVLRGARPLFASRRLGIAGRRVLLATLTAGARAPKGTRFQRVSIAGVPVQRVQPPHAATSGTLIYLHGGAYALGSARGYRGLAAQLAAAAGMTALVPDYTRAPHAHYPVALEEMAAVYTRLLDDGLDPKTTVIAGDSAGGGLTLALAMALRDRGIQAPAALGLICPWADLAVDIEATRPALRDPLILPSMCTEWAPRYVGSSDPRLPGISPVYGDMSGLPPIVMQTAGDDPICVDADKIETACAASKTSIEHRRFAGMWHDFHLQVSLLPEARDAIADLGARLRGHLHQSQGQPRGVVK
Atome Classification :
(22 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180...-...-.190.......200.......210.......220.......230.......240.......250...--....260........270.......280.......290.......300......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MN
L
R
K
N
V
I
R
S
V
L
RGARP
L
F
ASRRLGIAG
R
R
V
L
L
A
T
LTAGARAPKGT
R
F
Q
R
V
S
IAGVPVQRVQPPHAATS
G
T
L
I
Y
LHGGAYALGSARGY
R
G
L
A
A
Q
L
A
A
AAGM
T
A
LVPDYTRAPHAHYP
V
A
L
E
E
M
A
A
V
Y
T
R
L
L
DDGLDPK
T
T
V
I
AGDSAGG
G
L
T
L
A
L
A
M
A
L
R
DRGIQAPAALGLICPWA
D
L
A
V
D
I
EA-TRP-ALRDPLI
L
P
S
M
C
T
E
W
A
P
RYVGSSDPRLPGISPVYGDMSGLP
P
I
V
M
QTAGDD
P
I
C
V
D
A
D
K
I
E
T
A
CAAS--KTS
I
E
-
H
R
R
F
AGM
W
H
D
F
H
L
Q
V
S
LLP
E
A
R
D
A
I
A
D
L
G
A
R
L
R
G
H
L
H
QSQGQPRGVVK
8
PsiBlast_PDB
89.88
33%
-100
- C1 -
3H1A
-
?
A:
[39-292]
----------------------------------------
K
A
A
D
D
I
Q
V
E
Q
V
T
V
A
G
C
A
A
E
W
V
R
A
P
G
C
Q
A
G
K
A
I
L
Y
L
H
G
G
G
Y
V
M
G
S
I
N
T
H
R
S
M
V
G
E
I
S
R
A
S
Q
A
A
A
L
L
L
D
Y
R
L
A
P
E
H
P
F
P
A
A
V
E
D
G
V
A
A
Y
R
W
L
L
D
Q
G
F
K
P
Q
H
L
S
I
S
G
D
S
A
G
G
G
L
V
L
A
V
L
V
S
A
R
D
Q
G
L
P
M
P
A
S
A
I
P
I
S
P
W
A
D
M
T
C
T
N
D
S
-
F
K
T
R
A
E
A
D
P
M
V
A
P
G
G
I
N
K
M
A
A
R
Y
L
N
G
A
D
A
K
H
P
Y
A
S
P
N
F
A
N
L
K
G
L
P
P
L
L
I
H
V
G
R
D
E
V
L
L
D
D
S
I
K
L
D
A
K
A
K
A
D
GV
K
S
T
L
E
I
W
D
D
M
I
H
V
W
H
A
F
H
---
P
M
L
P
E
G
K
Q
A
I
V
R
V
G
E
F
M
R
---------------
4
PsiBlast_PDB
89.39
33%
-99
- C1 -
3G9Z
-
?
A:
[39-292]
----------------------------------------
K
A
A
D
D
I
Q
V
E
Q
V
T
V
A
G
C
A
A
E
W
V
R
A
P
G
C
Q
A
G
K
A
I
L
Y
L
H
G
G
G
Y
V
M
G
S
I
N
T
H
R
S
M
V
G
E
I
S
R
A
S
Q
A
A
A
L
L
L
D
Y
R
L
A
P
E
H
P
F
P
A
A
V
E
D
G
V
A
A
Y
R
W
L
L
D
Q
G
F
K
P
Q
H
L
S
I
S
G
D
S
A
G
G
G
L
V
L
A
V
L
V
S
A
R
D
Q
G
L
P
M
P
A
S
A
I
P
I
S
P
W
A
D
M
T
C
T
N
D
S
-
F
K
T
R
A
E
A
D
P
M
V
A
P
G
G
I
N
K
M
A
A
R
Y
L
N
G
A
D
A
K
H
P
Y
A
S
P
N
F
A
N
L
K
G
L
P
P
L
L
I
H
V
G
R
D
E
V
L
L
D
D
S
I
K
L
D
A
K
A
K
A
D
GV
K
S
T
L
E
I
W
D
D
M
I
H
V
W
H
A
F
H
---
P
M
L
P
E
G
K
Q
A
I
V
R
V
G
E
F
M
R
---------------
1
PsiBlast_PDB
89.26
33%
-98
- C1 -
3FAK
1
?
A:
[52-305]
----------------------------------------
K
A
A
D
D
I
Q
V
E
Q
V
T
V
A
G
C
A
A
E
W
V
R
A
P
G
C
Q
A
G
K
A
I
L
Y
L
H
G
G
G
Y
V
M
G
S
I
N
T
H
R
S
M
V
G
E
I
S
R
A
S
Q
A
A
A
L
L
L
D
Y
R
L
A
P
E
H
P
F
P
A
A
V
E
D
G
V
A
A
Y
R
W
L
L
D
Q
G
F
K
P
Q
H
L
S
I
S
G
D
S
A
G
G
G
L
V
L
A
V
L
V
S
A
R
D
Q
G
L
P
M
P
A
S
A
I
P
I
S
P
W
A
D
M
T
C
T
N
D
S
-
F
K
T
R
A
E
A
D
P
M
V
A
P
G
G
I
N
K
M
A
A
R
Y
L
N
G
A
D
A
K
H
P
Y
A
S
P
N
F
A
N
L
K
G
L
P
P
L
L
I
H
V
G
R
D
E
V
L
L
D
D
S
I
K
L
D
A
K
A
K
A
D
GV
K
S
T
L
E
I
W
D
D
M
I
H
V
W
H
A
F
H
---
P
M
L
P
E
G
K
Q
A
I
V
R
V
G
E
F
M
R
---------------
39
HHSearch
88.97
34%
-97
- C1 -
4XVC
1
?
A:
[46-316]
--------------------------
D
D
D
R
R
L
Y
E
T
M
L
G
S
M
P
L
D
D
D
I
Q
T
E
R
L
G
V
N
G
V
P
A
E
W
I
Y
A
P
G
A
R
D
D
Q
V
F
L
Y
L
H
G
G
G
Y
V
I
G
S
M
R
T
H
R
V
M
L
S
H
I
A
R
A
A
G
C
R
V
L
G
L
D
Y
R
L
A
P
E
T
P
F
P
A
P
V
E
D
T
V
A
A
Y
R
W
L
L
A
H
G
Y
D
P
S
R
I
A
L
G
G
D
S
A
G
G
G
L
V
V
A
A
L
V
A
L
R
Y
I
G
E
P
L
P
A
A
G
V
C
L
S
P
W
I
D
M
E
A
T
G
E
S
F
T
T
N
-
A
T
M
D
P
S
V
N
K
E
R
V
M
S
I
A
A
L
Y
L
G
G
K
N
P
Q
A
P
L
A
S
P
L
Y
A
D
L
Q
G
L
P
P
L
L
V
Q
V
G
G
I
E
T
L
L
D
D
A
R
A
L
T
T
R
A
K
A
A
--
G
V
D
A
D
-
L
E
V
W
D
D
M
P
H
V
W
Q
H
F
A
P
I
L
P
E
G
K
Q
A
I
A
R
I
G
E
F
L
R
K
Q
I
------------
40
HHSearch
88.44
31%
-100
* C1 *
3FAK
1
?
A:
[54-310]
------------------------------------------
A
D
D
I
Q
V
E
Q
V
T
V
A
G
C
A
A
E
W
V
R
A
P
G
C
Q
A
G
K
A
I
L
Y
L
H
G
G
G
Y
V
M
G
S
I
N
T
H
R
S
M
V
G
E
I
S
R
A
S
Q
A
A
A
L
L
L
D
Y
R
L
A
P
E
H
P
F
P
A
A
V
E
D
G
V
A
A
Y
R
W
L
L
D
Q
G
F
K
P
Q
H
L
S
I
S
G
D
S
A
G
G
G
L
V
L
A
V
L
V
S
A
R
D
Q
G
L
P
M
P
A
S
A
I
P
I
S
P
W
A
D
M
T
C
T
N
D
S
F
K
T
R
-
A
E
A
D
P
M
V
A
P
G
G
I
N
K
M
A
A
R
Y
L
N
G
A
D
A
K
H
P
Y
A
S
P
N
F
A
N
L
K
G
L
P
P
L
L
I
H
V
G
R
D
E
V
L
L
D
D
S
I
K
L
D
A
K
A
K
A
D
--
G
V
K
S
T
-
L
E
I
W
D
D
M
I
H
V
W
H
A
F
H
P
M
L
P
E
G
K
Q
A
I
V
R
V
G
E
F
M
R
E
Q
W
A
A
----------
24
PsiBlast_CBE
88.11
33%
-100
- C1 -
4XVC
1
?
E:
[49-316]
-----------------------------
R
R
L
Y
E
T
M
L
G
S
M
P
L
D
D
D
I
Q
T
E
R
L
G
V
N
G
V
P
A
E
W
I
Y
A
P
G
A
R
D
D
Q
V
F
L
Y
L
H
G
G
G
Y
V
I
G
S
M
R
T
H
R
V
M
L
S
H
I
A
R
A
A
G
C
R
V
L
G
L
D
Y
R
L
A
P
E
T
P
F
P
A
P
V
E
D
T
V
A
A
Y
R
W
L
L
A
H
G
Y
D
P
S
R
I
A
L
G
G
D
S
A
G
G
G
L
V
V
A
A
L
V
A
L
R
Y
I
G
E
P
L
P
A
A
G
V
C
L
S
P
W
I
D
M
E
A
T
G
E
S
F
T
T
N
-
A
T
M
D
P
S
V
N
K
E
R
V
M
S
I
A
A
L
Y
L
G
G
K
N
P
Q
A
P
L
A
S
P
L
Y
A
D
L
Q
G
L
P
P
L
L
V
Q
V
G
G
I
E
T
L
L
D
D
A
R
A
L
T
T
R
A
K
A
A
--
G
V
D
A
D
-
L
E
V
W
D
D
M
P
H
V
W
Q
H
F
A
P
I
L
P
E
G
K
Q
A
I
A
R
I
G
E
F
L
R
K
Q
I
------------
23
PsiBlast_CBE
88.08
33%
-100
- C1 -
4XVC
1
?
F:
[49-316]
-----------------------------
R
R
L
Y
E
T
M
L
G
S
M
P
L
D
D
D
I
Q
T
E
R
L
G
V
N
G
V
P
A
E
W
I
Y
A
P
G
A
R
D
D
Q
V
F
L
Y
L
H
G
G
G
Y
V
I
G
S
M
R
T
H
R
V
M
L
S
H
I
A
R
A
A
G
C
R
V
L
G
L
D
Y
R
L
A
P
E
T
P
F
P
A
P
V
E
D
T
V
A
A
Y
R
W
L
L
A
H
G
Y
D
P
S
R
I
A
L
G
G
D
S
A
G
G
G
L
V
V
A
A
L
V
A
L
R
Y
I
G
E
P
L
P
A
A
G
V
C
L
S
P
W
I
D
M
E
A
T
G
E
S
F
T
T
N
-
A
T
M
D
P
S
V
N
K
E
R
V
M
S
I
A
A
L
Y
L
G
G
K
N
P
Q
A
P
L
A
S
P
L
Y
A
D
L
Q
G
L
P
P
L
L
V
Q
V
G
G
I
E
T
L
L
D
D
A
R
A
L
T
T
R
A
K
A
A
--
G
V
D
A
D
-
L
E
V
W
D
D
M
P
H
V
W
Q
H
F
A
P
I
L
P
E
G
K
Q
A
I
A
R
I
G
E
F
L
R
K
Q
I
------------
14
PsiBlast_PDB
87.89
33%
-98
- C1 -
4XVC
1
?
A:
[49-316]
-----------------------------
R
R
L
Y
E
T
M
L
G
S
M
P
L
D
D
D
I
Q
T
E
R
L
G
V
N
G
V
P
A
E
W
I
Y
A
P
G
A
R
D
D
Q
V
F
L
Y
L
H
G
G
G
Y
V
I
G
S
M
R
T
H
R
V
M
L
S
H
I
A
R
A
A
G
C
R
V
L
G
L
D
Y
R
L
A
P
E
T
P
F
P
A
P
V
E
D
T
V
A
A
Y
R
W
L
L
A
H
G
Y
D
P
S
R
I
A
L
G
G
D
S
A
G
G
G
L
V
V
A
A
L
V
A
L
R
Y
I
G
E
P
L
P
A
A
G
V
C
L
S
P
W
I
D
M
E
A
T
G
E
S
F
T
T
N
-
A
T
M
D
P
S
V
N
K
E
R
V
M
S
I
A
A
L
Y
L
G
G
K
N
P
Q
A
P
L
A
S
P
L
Y
A
D
L
Q
G
L
P
P
L
L
V
Q
V
G
G
I
E
T
L
L
D
D
A
R
A
L
T
T
R
A
K
A
A
--
G
V
D
A
D
-
L
E
V
W
D
D
M
P
H
V
W
Q
H
F
A
P
I
L
P
E
G
K
Q
A
I
A
R
I
G
E
F
L
R
K
Q
I
------------
21
PsiBlast_CBE
87.78
33%
-99
- C1 -
4XVC
1
?
H:
[49-316]
-----------------------------
R
R
L
Y
E
T
M
L
G
S
M
P
L
D
D
D
I
Q
T
E
R
L
G
V
N
G
V
P
A
E
W
I
Y
A
P
G
A
R
D
D
Q
V
F
L
Y
L
H
G
G
G
Y
V
I
G
S
M
R
T
H
R
V
M
L
S
H
I
A
R
A
A
G
C
R
V
L
G
L
D
Y
R
L
A
P
E
T
P
F
P
A
P
V
E
D
T
V
A
A
Y
R
W
L
L
A
H
G
Y
D
P
S
R
I
A
L
G
G
D
S
A
G
G
G
L
V
V
A
A
L
V
A
L
R
Y
I
G
E
P
L
P
A
A
G
V
C
L
S
P
W
I
D
M
E
A
T
G
E
S
F
T
T
N
-
A
T
M
D
P
S
V
N
K
E
R
V
M
S
I
A
A
L
Y
L
G
G
K
N
P
Q
A
P
L
A
S
P
L
Y
A
D
L
Q
G
L
P
P
L
L
V
Q
V
G
G
I
E
T
L
L
D
D
A
R
A
L
T
T
R
A
K
A
A
--
G
V
D
A
D
-
L
E
V
W
D
D
M
P
H
V
W
Q
H
F
A
P
I
L
P
E
G
K
Q
A
I
A
R
I
G
E
F
L
R
K
Q
I
------------
27
PsiBlast_CBE
87.62
33%
-99
- C1 -
4XVC
1
?
B:
[49-316]
-----------------------------
R
R
L
Y
E
T
M
L
G
S
M
P
L
D
D
D
I
Q
T
E
R
L
G
V
N
G
V
P
A
E
W
I
Y
A
P
G
A
R
D
D
Q
V
F
L
Y
L
H
G
G
G
Y
V
I
G
S
M
R
T
H
R
V
M
L
S
H
I
A
R
A
A
G
C
R
V
L
G
L
D
Y
R
L
A
P
E
T
P
F
P
A
P
V
E
D
T
V
A
A
Y
R
W
L
L
A
H
G
Y
D
P
S
R
I
A
L
G
G
D
S
A
G
G
G
L
V
V
A
A
L
V
A
L
R
Y
I
G
E
P
L
P
A
A
G
V
C
L
S
P
W
I
D
M
E
A
T
G
E
S
F
T
T
N
-
A
T
M
D
P
S
V
N
K
E
R
V
M
S
I
A
A
L
Y
L
G
G
K
N
P
Q
A
P
L
A
S
P
L
Y
A
D
L
Q
G
L
P
P
L
L
V
Q
V
G
G
I
E
T
L
L
D
D
A
R
A
L
T
T
R
A
K
A
A
--
G
V
D
A
D
-
L
E
V
W
D
D
M
P
H
V
W
Q
H
F
A
P
I
L
P
E
G
K
Q
A
I
A
R
I
G
E
F
L
R
K
Q
I
------------
25
PsiBlast_CBE
86.77
33%
-100
- C1 -
4XVC
1
?
D:
[49-316]
-----------------------------
R
R
L
Y
E
T
M
L
G
S
M
P
L
D
D
D
I
Q
T
E
R
L
G
V
N
G
V
P
A
E
W
I
Y
A
P
G
A
R
D
D
Q
V
F
L
Y
L
H
G
G
G
Y
V
I
G
S
M
R
T
H
R
V
M
L
S
H
I
A
R
A
A
G
C
R
V
L
G
L
D
Y
R
L
A
P
E
T
P
F
P
A
P
V
E
D
T
V
A
A
Y
R
W
L
L
A
H
G
Y
D
P
S
R
I
A
L
G
G
D
S
A
G
G
G
L
V
V
A
A
L
V
A
L
R
Y
I
G
E
P
L
P
A
A
G
V
C
L
S
P
W
I
D
M
E
A
T
G
E
S
F
T
T
N
-
A
T
M
D
P
S
V
N
K
E
R
V
M
S
I
A
A
L
Y
L
G
G
K
N
P
Q
A
P
L
A
S
P
L
Y
A
D
L
Q
G
L
P
P
L
L
V
Q
V
G
G
I
E
T
L
L
D
D
A
R
A
L
T
T
R
A
K
A
A
--
G
V
D
A
D
-
L
E
V
W
D
D
M
P
H
V
W
Q
H
F
A
P
I
L
P
E
G
K
Q
A
I
A
R
I
G
E
F
L
R
K
Q
I
------------
11
PsiBlast_PDB
86.56
33%
-99
- C1 -
3L1I
-
?
A:
[39-292]
----------------------------------------
K
A
A
D
D
I
Q
V
E
Q
V
T
V
A
G
C
A
A
E
W
V
R
A
P
G
C
Q
A
G
K
A
I
L
Y
L
H
G
G
G
Y
V
M
G
S
I
N
T
H
R
S
M
V
G
E
I
S
R
A
S
Q
A
A
A
L
L
L
D
Y
R
L
A
P
E
H
P
F
P
A
A
V
E
D
G
V
A
A
Y
R
W
L
L
D
Q
G
F
K
P
Q
H
L
S
I
S
G
D
S
A
G
G
G
L
V
L
A
V
L
V
S
A
R
D
Q
G
L
P
M
P
A
S
A
I
P
I
S
P
W
A
D
M
T
C
T
N
D
S
-
F
K
T
R
A
E
A
D
P
M
---
G
G
I
N
K
M
A
A
R
Y
L
N
G
A
D
A
K
H
P
Y
A
S
P
N
F
A
N
L
K
G
L
P
P
L
L
I
H
V
G
R
D
E
V
L
L
D
D
S
I
K
L
D
A
K
A
K
A
D
GV
K
S
T
L
E
I
W
D
D
M
I
H
V
W
H
A
F
H
---
P
M
L
P
E
G
K
Q
A
I
V
R
V
G
E
F
M
R
---------------
22
PsiBlast_CBE
86.55
33%
-100
- C1 -
4XVC
1
?
G:
[49-316]
-----------------------------
R
R
L
Y
E
T
M
L
G
S
M
P
L
D
D
D
I
Q
T
E
R
L
G
V
N
G
V
P
A
E
W
I
Y
A
P
G
A
R
D
D
Q
V
F
L
Y
L
H
G
G
G
Y
V
I
G
S
M
R
T
H
R
V
M
L
S
H
I
A
R
A
A
G
C
R
V
L
G
L
D
Y
R
L
A
P
E
T
P
F
P
A
P
V
E
D
T
V
A
A
Y
R
W
L
L
A
H
G
Y
D
P
S
R
I
A
L
G
G
D
S
A
G
G
G
L
V
V
A
A
L
V
A
L
R
Y
I
G
E
P
L
P
A
A
G
V
C
L
S
P
W
I
D
M
E
A
T
G
E
S
F
T
T
N
-
A
T
M
D
P
S
V
N
K
E
R
V
M
S
I
A
A
L
Y
L
G
G
K
N
P
Q
A
P
L
A
S
P
L
Y
A
D
L
Q
G
L
P
P
L
L
V
Q
V
G
G
I
E
T
L
L
D
D
A
R
A
L
T
T
R
A
K
A
A
--
G
V
D
A
D
-
L
E
V
W
D
D
M
P
H
V
W
Q
H
F
A
P
I
L
P
E
G
K
Q
A
I
A
R
I
G
E
F
L
R
K
Q
I
------------
12
PsiBlast_PDB
86.49
33%
-97
- C1 -
3L1J
-
?
A:
[39-292]
----------------------------------------
K
A
A
D
D
I
Q
V
E
Q
V
T
V
A
G
C
A
A
E
W
V
R
A
P
G
C
Q
A
G
K
A
I
L
Y
L
H
G
G
G
Y
V
M
G
S
I
N
T
H
R
S
M
V
G
E
I
S
R
A
S
Q
A
A
A
L
L
L
D
Y
R
L
A
P
E
H
P
F
P
A
A
V
E
D
G
V
A
A
Y
R
W
L
L
D
Q
G
F
K
P
Q
H
L
S
I
S
G
D
S
A
G
G
G
L
V
L
A
V
L
V
S
A
R
D
Q
G
L
P
M
P
A
S
A
I
P
I
S
P
W
A
D
M
T
C
T
N
D
S
-
F
K
T
R
A
E
A
D
P
M
---
G
G
I
N
K
M
A
A
R
Y
L
N
G
A
D
A
K
H
P
Y
A
S
P
N
F
A
N
L
K
G
L
P
P
L
L
I
H
V
G
R
D
E
V
L
L
D
D
S
I
K
L
D
A
K
A
K
A
D
GV
K
S
T
L
E
I
W
D
D
M
I
H
V
W
H
A
F
H
---
P
M
L
P
E
G
K
Q
A
I
V
R
V
G
E
F
M
R
---------------
26
PsiBlast_CBE
86.47
33%
-100
- C1 -
4XVC
1
?
C:
[49-316]
-----------------------------
R
R
L
Y
E
T
M
L
G
S
M
P
L
D
D
D
I
Q
T
E
R
L
G
V
N
G
V
P
A
E
W
I
Y
A
P
G
A
R
D
D
Q
V
F
L
Y
L
H
G
G
G
Y
V
I
G
S
M
R
T
H
R
V
M
L
S
H
I
A
R
A
A
G
C
R
V
L
G
L
D
Y
R
L
A
P
E
T
P
F
P
A
P
V
E
D
T
V
A
A
Y
R
W
L
L
A
H
G
Y
D
P
S
R
I
A
L
G
G
D
S
A
G
G
G
L
V
V
A
A
L
V
A
L
R
Y
I
G
E
P
L
P
A
A
G
V
C
L
S
P
W
I
D
M
E
A
T
G
E
S
F
T
T
N
-
A
T
M
D
P
S
V
N
K
E
R
V
M
S
I
A
A
L
Y
L
G
G
K
N
P
Q
A
P
L
A
S
P
L
Y
A
D
L
Q
G
L
P
P
L
L
V
Q
V
G
G
I
E
T
L
L
D
D
A
R
A
L
T
T
R
A
K
A
A
--
G
V
D
A
D
-
L
E
V
W
D
D
M
P
H
V
W
Q
H
F
A
P
I
L
P
E
G
K
Q
A
I
A
R
I
G
E
F
L
R
K
Q
I
------------
10
PsiBlast_PDB
86.45
33%
-101
- C1 -
3L1H
-
?
A:
[39-292]
----------------------------------------
K
A
A
D
D
I
Q
V
E
Q
V
T
V
A
G
C
A
A
E
W
V
R
A
P
G
C
Q
A
G
K
A
I
L
Y
L
H
G
G
G
Y
V
M
G
S
I
N
T
H
R
S
M
V
G
E
I
S
R
A
S
Q
A
A
A
L
L
L
D
Y
R
L
A
P
E
H
P
F
P
A
A
V
E
D
G
V
A
A
Y
R
W
L
L
D
Q
G
F
K
P
Q
H
L
S
I
S
G
D
S
A
G
G
G
L
V
L
A
V
L
V
S
A
R
D
Q
G
L
P
M
P
A
S
A
I
P
I
S
P
W
A
D
M
T
C
T
N
D
S
-
F
K
T
R
A
E
A
D
P
M
---
G
G
I
N
K
M
A
A
R
Y
L
N
G
A
D
A
K
H
P
Y
A
S
P
N
F
A
N
L
K
G
L
P
P
L
L
I
H
V
G
R
D
E
V
L
L
D
D
S
I
K
L
D
A
K
A
K
A
D
GV
K
S
T
L
E
I
W
D
D
M
I
H
V
W
H
A
F
H
---
P
M
L
P
E
G
K
Q
A
I
V
R
V
G
E
F
M
R
---------------
9
PsiBlast_PDB
86.43
33%
-99
- C1 -
3H1B
-
?
A:
[39-292]
----------------------------------------
K
A
A
D
D
I
Q
V
E
Q
V
T
V
A
G
C
A
A
E
W
V
R
A
P
G
C
Q
A
G
K
A
I
L
Y
L
H
G
G
G
Y
V
M
G
S
I
N
T
H
R
S
M
V
G
E
I
S
R
A
S
Q
A
A
A
L
L
L
D
Y
R
L
A
P
E
H
P
F
P
A
A
V
E
D
G
V
A
A
Y
R
W
L
L
D
Q
G
F
K
P
Q
H
L
S
I
S
G
D
S
A
G
G
G
L
V
L
A
V
L
V
S
A
R
D
Q
G
L
P
M
P
A
S
A
I
P
I
S
P
W
A
D
M
T
C
T
N
D
S
-
F
K
T
R
A
E
A
D
P
M
V
A
P
G
G
I
N
K
M
A
A
R
Y
L
N
G
A
D
A
K
H
P
Y
A
S
P
N
F
A
N
L
K
G
L
P
P
L
L
I
H
V
G
R
D
E
V
L
L
D
D
S
I
K
L
D
A
K
A
K
A
D
GV
K
S
T
L
E
I
W
D
D
M
I
H
V
W
H
A
F
H
---
P
M
L
P
E
G
K
Q
A
I
V
R
V
G
E
F
M
R
---------------
3
PsiBlast_PDB
86.30
33%
-99
- C1 -
3G9U
-
?
A:
[39-292]
----------------------------------------
K
A
A
D
D
I
Q
V
E
Q
V
T
V
A
G
C
A
A
E
W
V
R
A
P
G
C
Q
A
G
K
A
I
L
Y
L
H
G
G
G
Y
V
M
G
S
I
N
T
H
R
S
M
V
G
E
I
S
R
A
S
Q
A
A
A
L
L
L
D
Y
R
L
A
P
E
H
P
F
P
A
A
V
E
D
G
V
A
A
Y
R
W
L
L
D
Q
G
F
K
P
Q
H
L
S
I
S
G
D
S
A
G
G
G
L
V
L
A
V
L
V
S
A
R
D
Q
G
L
P
M
P
A
S
A
I
P
I
S
P
W
A
D
M
T
C
T
N
D
S
-
F
K
T
R
A
E
A
D
P
M
--
P
G
G
I
N
K
M
A
A
R
Y
L
N
G
A
D
A
K
H
P
Y
A
S
P
N
F
A
N
L
K
G
L
P
P
L
L
I
H
V
G
R
D
E
V
L
L
D
D
S
I
K
L
D
A
K
A
K
A
D
GV
K
S
T
L
E
I
W
D
D
M
I
H
V
W
H
A
F
H
---
P
M
L
P
E
G
K
Q
A
I
V
R
V
G
E
F
M
R
---------------
7
PsiBlast_PDB
86.09
33%
-99
- C1 -
3H19
-
?
A:
[39-292]
----------------------------------------
K
A
A
D
D
I
Q
V
E
Q
V
T
V
A
G
C
A
A
E
W
V
R
A
P
G
C
Q
A
G
K
A
I
L
Y
L
H
G
G
G
Y
V
M
G
S
I
N
T
H
R
S
M
V
G
E
I
S
R
A
S
Q
A
A
A
L
L
L
D
Y
R
L
A
P
E
H
P
F
P
A
A
V
E
D
G
V
A
A
Y
R
W
L
L
D
Q
G
F
K
P
Q
H
L
S
I
S
G
D
S
A
G
G
G
L
V
L
A
V
L
V
S
A
R
D
Q
G
L
P
M
P
A
S
A
I
P
I
S
P
W
A
D
M
T
C
T
N
D
S
-
F
K
T
R
A
E
A
D
P
M
---
G
G
I
N
K
M
A
A
R
Y
L
N
G
A
D
A
K
H
P
Y
A
S
P
N
F
A
N
L
K
G
L
P
P
L
L
I
H
V
G
R
D
E
V
L
L
D
D
S
I
K
L
D
A
K
A
K
A
D
GV
K
S
T
L
E
I
W
D
D
M
I
H
V
W
H
A
F
H
---
P
M
L
P
E
G
K
Q
A
I
V
R
V
G
E
F
M
R
---------------
2
PsiBlast_PDB
85.91
33%
-95
- C1 -
3G9T
-
?
A:
[39-292]
----------------------------------------
K
A
A
D
D
I
Q
V
E
Q
V
T
V
A
G
C
A
A
E
W
V
R
A
P
G
C
Q
A
G
K
A
I
L
Y
L
H
G
G
G
Y
V
M
G
S
I
N
T
H
R
S
M
V
G
E
I
S
R
A
S
Q
A
A
A
L
L
L
D
Y
R
L
A
P
E
H
P
F
P
A
A
V
E
D
G
V
A
A
Y
R
W
L
L
D
Q
G
F
K
P
Q
H
L
S
I
S
G
D
S
A
G
G
G
L
V
L
A
V
L
V
S
A
R
D
Q
G
L
P
M
P
A
S
A
I
P
I
S
P
W
A
D
M
T
C
T
N
D
S
-
F
K
T
R
A
E
A
D
P
M
--
P
G
G
I
N
K
M
A
A
R
Y
L
N
G
A
D
A
K
H
P
Y
A
S
P
N
F
A
N
L
K
G
L
P
P
L
L
I
H
V
G
R
D
E
V
L
L
D
D
S
I
K
L
D
A
K
A
K
A
D
GV
K
S
T
L
E
I
W
D
D
M
I
H
V
W
H
A
F
H
---
P
M
L
P
E
G
K
Q
A
I
V
R
V
G
E
F
M
R
---------------
6
PsiBlast_PDB
84.43
33%
-97
- C1 -
3H18
2
?
A:
[52-305]
----------------------------------------
K
A
A
D
D
I
Q
V
E
Q
V
T
V
A
G
C
A
A
E
W
V
R
A
P
G
C
Q
A
G
K
A
I
L
Y
L
H
G
G
G
Y
V
M
G
S
I
N
T
H
R
S
M
V
G
E
I
S
R
A
S
Q
A
A
A
L
L
L
D
Y
R
L
A
P
E
H
P
F
P
A
A
V
E
D
G
V
A
A
Y
R
W
L
L
D
Q
G
F
K
P
Q
H
L
S
I
S
G
D
S
A
G
G
G
L
V
L
A
V
L
V
S
A
R
D
Q
G
L
P
M
P
A
S
A
I
P
I
S
P
W
A
D
M
T
C
T
N
D
S
-
F
K
T
R
A
E
A
D
P
M
---
G
G
I
N
K
M
A
A
R
Y
L
N
G
A
D
A
K
H
P
Y
A
S
P
N
F
A
N
L
K
G
L
P
P
L
L
I
H
V
G
R
D
E
V
L
L
D
D
S
I
K
L
D
A
K
A
K
A
D
G
V
K
S
T
L
E
I
W
D
D
M
I
H
V
W
H
A
F
H
---
P
M
L
P
E
G
K
Q
A
I
V
R
V
G
E
F
M
R
---------------
5
PsiBlast_PDB
81.57
33%
-93
- C1 -
3H17
1
?
A:
[52-305]
----------------------------------------
K
A
A
D
D
I
Q
V
E
Q
V
T
V
A
G
C
A
A
E
W
V
R
A
P
G
C
Q
A
G
K
A
I
L
Y
L
H
G
G
G
Y
V
M
G
S
I
N
T
H
R
S
M
V
G
E
I
S
R
A
S
Q
A
A
A
L
L
L
D
Y
R
L
A
P
E
H
P
F
P
A
A
V
E
D
G
V
A
A
Y
R
W
L
L
D
Q
G
F
K
P
Q
H
L
S
I
S
G
D
S
A
G
G
G
L
V
L
A
V
L
V
S
A
R
D
Q
G
L
P
M
P
A
S
A
I
P
I
S
P
W
A
D
M
T
C
T
N
D
S
-
F
K
T
R
A
E
A
D
----
P
G
G
I
N
K
M
A
A
R
Y
L
N
G
A
D
A
K
H
P
Y
A
S
P
N
F
A
N
L
K
G
L
P
P
L
L
I
H
V
G
R
D
E
V
L
L
D
D
S
I
K
L
D
A
K
A
K
A
D
G
V
K
S
T
L
E
I
W
D
D
M
I
H
V
W
H
A
F
H
---
P
M
L
P
E
G
K
Q
A
I
V
R
V
G
E
F
M
R
---------------