@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv3359: (2016-05-19 )
MAPGSCEAPDVFNPAKLGPLTLRNRVIKAATFEARTPDALVTDDLIEYHRLPAAGGVAMTTVAYCAVSPGGRTGGNQIWMRPHAVPGLRRLTEAIHAEGAAISAQIGHAGPVADARSNQATALAPVRFFNPIAMRFAQKATREDIDDVLAAHAHAARLAVDAGFDAVEIHLGHNYLASAFLSPLLNRRDDEFGGSLQNRAKVARGLVMAVRRAVRQQVAVTAKLNMTDGIRGGITVDEALTTARWLQDDGGLDAIELTAGSSLVNPMYLFRGDAPVKEFAAAFKPPLRWGIRMTGHRFFREYPYRDAYLLREARLFRAELTIPLILLGGITNRTTMDLAMAEGFEFVAMARALLAEPDLVNRIAAEGSQVRSACTHCNQCMATIYRRTHCVVTGAP
Atome Classification :
(20 SA)
.........10.......-.20........30-....-.--.--...40--........50.........60........---70...---.-.--.--.-.-80-........90........100.......110......-------------.120.......---130-.--------------.---------------.......140....-...150.......-160.......170...-.-...180.......190...-.....200.......210...----....220.....-..230.--...--.-.-..----.240.......250----.........260.......270.......280.......290.......300.......310.......320.........330.......340.-.-.....350.......360.......370.......-380...--.--..-.390....--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAPGSCEAPDVFNPAKL
G
-
P
L
T
L
R
N
R
V
I
K
A
A
--
T
FEA-R--T--PDA
L
V
--
T
D
D
L
I
E
Y
HR-LPAAGGV
A
M
T
T
V
A
Y
C
A
VSP---GGRTG---G-N--
Q
--
I
-
W
-MR-PHAV
P
G
L
R
R
L
T
E
A
I
HAEG
A
A
I
S
A
QIGHAGPVADARSN-------------QATALA
P
V
R
FF---
N
---
P
--------------
I
---------------
A
M
R
F
A
Q
K
A
T
R
E
D
I
D
-
D
V
L
A
A
H
A
H
A
A
R
L
A
-VDAGF
D
A
V
E
I
HLG
H
N
Y
-
L
-
A
S
A
F
L
S
P
L
L
NRRDD-EFG
G
-
S
L
Q
N
R
A
K
V
A
R
G
L
V
M
A
V
R
R
A
V
R
----
Q
Q
V
A
V
T
A
K
LNMT-DGI--R--G
G
I
--
T
-
V
-
D
E
----
A
L
T
T
A
R
W
LQDDG------G
L
D
A
I
E
LTAGSSLV
N
P
M
Y
L
FRGDA
P
V
K
E
F
A
A
AFKPPL
R
W
G
I
RM
T
G
H
R
F
F
R
EYPY
R
D
A
Y
L
L
R
E
A
R
L
F
R
AEL--
T
I
P
L
I
L
LGGITNR
T
T
M
D
L
A
M
AE
G
-
F
-
E
F
V
A
M
A
R
A
L
LAE
P
D
L
V
N
R
I
AAE
G
S
Q
V
R
S
A
C
T
H
C
N
Q
-
C
M
A
T
I
Y--R--R
T
-
H
C
V
V
TGAP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
HHSearch
90.62
28%
-94
- C4 -
3HGJ
2
?
A:
[2-338]
--------
A
L
L
F
T
P
L
E
L
G
-
G
L
R
L
K
N
R
L
A
M
S
P
--
M
C
Q
Y
S
A
--
T
--
L
E
G
E
V
--
T
D
W
H
L
L
H
Y
P
-
T
R
A
L
G
G
V
G
L
I
L
V
E
A
T
A
V
E
P
---
L
G
R
I
S
---
P
-
Y
--
D
--
L
G
I
-
W
S
-
E
D
H
L
P
G
L
K
E
L
A
R
R
I
R
E
A
G
A
V
P
G
I
Q
L
A
H
A
G
R
K
A
G
T
A
R
P
WEGGKPL------
G
W
R
V
V
G
P
S
P
I
P
---
F
---
D
--------------
E
---------------
G
Y
P
V
P
E
P
L
D
E
A
G
M
E
-
R
I
L
Q
A
F
V
E
G
A
R
R
A
-
L
R
A
G
F
Q
V
I
E
L
H
M
A
H
G
Y
-
L
-
L
S
S
F
L
S
P
L
S
N
Q
R
T
D
-
A
Y
G
G
-
S
L
E
N
R
M
R
F
P
L
Q
V
A
Q
A
V
R
E
V
V
P
----
R
E
L
P
L
F
V
R
V
S
A
T
-
D
W
G
--
E
--
G
G
W
--
S
-
L
-
E
D
----
T
L
A
F
A
R
R
L
K
-
E
L
------
G
V
D
L
L
D
C
S
S
G
G
V
V
L
R
V
R
----------------------------------
I
P
L
A
P
G
F
Q
V
P
F
A
D
A
V
R
K
R
V
--
G
L
R
T
G
A
V
G
L
I
T
T
P
E
Q
A
E
T
L
L
Q
A
G
-
S
A
D
L
V
L
L
G
R
V
L
L
R
D
P
Y
F
P
L
R
A
A
K
A
L
G
V
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
Fugue
90.55
26%
-94
- C4 -
1PS9
8
FADH_ECOLI
A:
[1-671]
------
S
Y
P
S
L
F
A
P
L
D
L
G
-
F
T
T
L
K
N
R
V
L
M
G
S
--
M
H
T
G
-
L
--
E
--
E
Y
P
D
G
--
A
E
R
L
A
A
F
Y
A
-
E
R
A
R
H
G
V
A
L
I
V
S
G
G
I
A
P
D
L
---
T
G
V
G
M
---
E
-
G
--
G
--
A
-
M
-
L
N
D
A
S
Q
I
P
H
H
R
T
I
T
E
A
V
H
Q
E
G
G
K
I
A
L
Q
I
L
H
T
G
----
R
Y
S
Y
-------------
Q
P
H
L
V
A
P
S
A
L
Q
---
A
---
P
--------------
I
---------------
N
R
F
V
P
H
E
L
S
H
E
E
I
L
-
Q
L
I
D
N
F
A
R
C
A
Q
L
A
-
R
E
A
G
Y
D
G
V
E
V
M
G
S
E
G
Y
-
L
-
I
N
E
F
L
T
L
R
T
N
Q
R
S
D
-
Q
W
G
G
-
D
Y
R
N
R
M
R
F
A
V
E
V
V
R
A
V
R
E
R
V
G
----
N
D
F
I
I
I
Y
R
L
S
M
L
-
D
L
V
--
E
--
D
G
G
--
T
-
F
-
A
E
----
T
V
E
L
A
Q
A
I
E
A
A
G
-------
A
T
I
I
N
T
G
I
G
W
H
E
A
R
I
P
T
I
A
T
-------------------------------
P
V
P
R
G
A
F
S
W
V
T
R
K
L
K
G
H
V
--
S
L
P
L
V
T
T
N
R
I
N
D
P
Q
V
A
D
D
I
L
S
R
G
-
D
A
D
M
V
S
M
A
R
P
F
L
A
D
A
E
L
L
S
K
A
Q
S
G
R
A
D
E
I
N
T
C
I
G
C
N
Q
A
C
L
D
Q
I
F
--
V
--
G
K
-
V
T
S
C
L
V
N
P
RACHETK
M
P
I
L
PAV
Q
K
K
N
L
A
V
V
G
AG
P
A
G
L
A
F
A
I
N
A
A
A
R
G
H
Q
V
T
L
F
D
AHSEIGGQ
F
N
I
A
K
Q
IPGKEE
F
Y
E
T
L
R
Y
Y
R
R
M
I
E
V
T
GVTLKLNHTVTADQLQAFD
E
T
I
L
A
S
G
I
V
P
R
TPPIDGIDHPKVLSYLDVLRDKAPVGN
K
V
A
I
I
G
CG
G
I
G
F
D
T
A
M
Y
L
S
QPGESTSQN
I
A
G
F
C
N
E
W
GIDSSLQQAGGLSPQ
G
M
Q
I
P
R
SPRQ
I
V
M
L
Q
RKASKPGQGLGKTT
G
W
I
H
R
T
T
L
L
S
R
G
V
K
M
I
P
GVSYQKIDDD
G
L
H
V
V
I
NG
E
T
Q
V
L
AVD
N
V
V
I
CA
G
Q
E
P
N
RALAQ
P
L
I
D
S
G
K
T
V
H
L
I
G
GCDVAMELD
A
R
R
A
I
A
Q
G
T
R
L
A
L
E
I------
50
HHSearch
90.33
28%
-92
* C4 *
3GR7
3
NAMA_GEOKA
A:
[2-329]
-------
N
T
M
L
F
S
P
Y
T
I
R
-
G
L
T
L
K
N
R
I
V
M
S
P
--
M
C
M
Y
-
S
--
C
DT
K
D
G
A
V
--
R
T
W
H
K
I
H
Y
P
-
A
R
A
V
G
Q
V
G
L
I
I
V
E
A
T
G
V
T
P
---
Q
G
R
I
S
---
E
-
R
--
D
--
L
-
G
I
W
S
-
D
D
H
I
A
G
L
R
E
L
V
G
L
V
K
E
H
G
A
A
I
G
I
Q
L
A
H
A
G
R
K
S
Q
V
P
G
----------------
E
I
I
A
P
S
A
V
P
---
F
---
D
--------------
D
---------------
S
S
P
T
P
K
E
M
T
K
A
D
I
E
-
E
T
V
Q
A
F
Q
N
G
A
R
R
A
-
K
E
A
G
F
D
V
I
E
I
H
A
A
H
G
Y
-
L
-
I
N
E
F
L
S
P
L
S
N
R
R
Q
D
-
E
Y
G
G
-
S
P
E
N
R
Y
R
F
L
G
E
V
I
D
A
V
R
E
V
W
------
D
G
P
L
F
V
R
I
S
A
S
-
D
Y
H
--
P
--
D
G
L
--
T
-
A
-
K
D
----
Y
V
P
Y
A
K
R
M
K
-
E
Q
------
G
V
D
L
V
D
V
S
S
G
A
I
V
P
A
R
-----------------------------------
M
N
V
Y
P
G
Y
Q
V
P
F
A
E
L
I
R
R
E
A
--
D
I
P
T
G
A
V
G
L
I
T
S
G
W
Q
A
E
E
I
L
Q
N
G
-
R
A
D
L
V
F
L
G
R
E
L
L
R
N
P
Y
W
P
Y
A
A
A
R
E
L
G
A
K
I
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
HHSearch
90.05
28%
-86
- C4 -
3L5L
11
?
A:
[2-343]
--------
S
A
L
F
E
P
Y
T
L
K
-
D
V
T
L
R
N
R
I
A
I
P
P
--
M
C
Q
Y
-
M
--
A
--
E
D
G
M
I
--
N
D
W
H
H
V
H
L
A
-
G
L
A
R
G
G
A
G
L
L
V
V
E
A
T
A
V
A
P
---
E
G
R
I
T
---
P
-
G
--
C
--
A
-
G
I
W
S
-
D
A
H
A
Q
A
F
V
P
V
V
Q
A
I
K
A
A
G
S
V
P
G
I
Q
I
A
H
A
G
R
K
A
S
A
N
R
P
WEGDDHIAADDTR
G
W
E
T
I
A
P
S
A
I
A
---
F
---
G
A-------------
H
---------------
L
P
K
V
P
R
E
M
T
L
D
D
I
A
-
R
V
K
Q
D
F
V
D
A
A
R
R
A
-
R
D
A
G
F
E
W
I
E
L
H
F
A
H
G
Y
-
L
-
G
Q
S
F
F
S
E
H
S
N
K
R
T
D
-
A
Y
G
G
-
S
F
D
N
R
S
R
F
L
L
E
T
L
A
A
V
R
E
V
W
P
----
E
N
L
P
L
T
A
R
F
G
V
L
-
E
Y
D
G-
R
--
D
E
Q
--
T
-
L
-
E
E
----
S
I
E
L
A
R
R
F
K
-
A
G
------
G
L
D
L
L
S
V
S
V
G
F
T
I
P
D
T
N
----------------------------------
I
P
W
G
P
A
F
M
G
P
I
A
E
R
V
R
R
E
A
--
K
L
P
V
T
S
A
W
G
F
G
T
P
Q
L
A
E
A
A
L
Q
A
N
-
Q
L
D
L
V
S
V
G
R
A
H
L
A
D
P
H
W
A
Y
F
A
A
K
E
L
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
89.43
26%
-90
- C4 -
1PS9
7
FADH_ECOLI
A:
[3-356]
--------
P
S
L
F
A
P
L
D
L
G
-
F
T
T
L
K
N
R
V
L
M
G
S
MH
T
G
L
E
-
E
--
Y
--
P
D
G
----
A
E
R
L
A
A
F
Y
A
-
E
R
A
R
H
G
V
A
L
--
I
V
S
G
G
I
A
P
DLT
G
V
G
M
E
---
G
-
G
--
A
--
M
-
L
-
N
D
-
A
S
Q
I
P
H
H
R
T
I
T
E
A
V
H
Q
E
G
G
K
I
A
L
Q
I
L
H
T
G
----
R
Y
S
Y
-------------
Q
P
H
L
V
A
P
S
A
L
Q
---
A
---
P
--------------
I
---------------
N
R
F
V
P
H
E
L
S
H
E
E
I
L
-
Q
L
I
D
N
F
A
R
C
A
Q
L
A
-
R
E
A
G
Y
D
G
V
E
V
M
G
S
E
G
Y
-
L
-
I
N
E
F
L
T
L
R
T
N
Q
R
S
D
-
Q
W
G
G
-
D
Y
R
N
R
M
R
F
A
V
E
V
V
R
A
V
R
E
R
V
G
----
N
D
F
I
I
I
Y
R
L
S
M
L
-
D
L
V
--
E
--
D
G
G
--
T
-
F
-
A
E
----
T
V
E
L
A
Q
---------------
A
I
E
-
A
A
G
A
T
I
I
N
T
G
I
G
W
H
-
E
A
R
I
P
T
I
A
T
---------------------
P
V
P
R
G
A
F
S
W
V
T
R
K
L
K
G
H
V
--
S
L
P
L
V
T
T
N
R
I
N
D
P
Q
V
A
D
D
I
L
S
R
G
D
A
-
D
M
V
S
M
A
R
P
F
L
A
D
A
E
L
L
S
K
A
Q
S
G
R
A
D
E
I
N
T
C
I
G
C
N
Q
A
C
L
D
Q
I
F
V
G
K
--
V
T
-
S
C
L
V
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
HHSearch
89.39
26%
-97
- C4 -
1PS9
7
FADH_ECOLI
A:
[2-358]
-------
Y
P
S
L
F
A
P
L
D
L
G
-
F
T
T
L
K
N
R
V
L
M
G
S
--
M
H
T
G
-
L
--
E
--
E
Y
P
D
G
--
A
E
R
L
A
A
F
Y
A
-
E
R
A
R
H
G
V
A
L
I
V
S
G
G
I
A
P
D
L
---
T
G
V
G
M
---
E
-
G
--
G
--
A
M
L
-
N
D
-
A
S
Q
I
P
H
H
R
T
I
T
E
A
V
H
Q
E
G
G
K
I
A
L
Q
I
L
H
T
G
R
Y
S
Y
Q
P
-----------------
H
L
V
A
P
S
A
L
Q
---
A
---
P
--------------
I
---------------
N
R
F
V
P
H
E
L
S
H
E
E
I
L
-
Q
L
I
D
N
F
A
R
C
A
Q
L
A
-
R
E
A
G
Y
D
G
V
E
V
M
G
S
E
G
Y
-
L
-
I
N
E
F
L
T
L
R
T
N
Q
R
S
D
-
Q
W
G
G
-
D
Y
R
N
R
M
R
F
A
V
E
V
V
R
A
V
R
E
R
V
G
----
N
D
F
I
I
I
Y
R
L
S
M
L
-
D
L
V
--
E
--
D
G
G
--
T
-
F
-
A
E
----
T
V
E
L
A
Q
A
I
E
-
A
A
------
G
A
T
I
I
N
T
G
I
G
W
H
E
A
R
I
P
--
T
------------
I
-----------------
A
T
P
V
P
R
G
A
F
S
W
V
T
R
K
L
K
G
H
V
--
S
L
P
L
V
T
T
N
R
I
N
D
P
Q
V
A
D
D
I
L
S
R
G
-
D
A
D
M
V
S
M
A
R
P
F
L
A
D
A
E
L
L
S
K
A
Q
S
G
R
A
D
E
I
N
T
C
I
G
C
N
Q
-
A
C
L
D
Q
I
--
F
V
G
K
V
T
S
C
L
V
N
P
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
HHSearch
88.86
25%
-100
- C4 -
3KRU
2
?
A:
[2-325]
--------
S
I
L
H
M
P
L
K
I
K
-
D
I
T
I
K
N
R
I
M
M
S
P
--
M
C
M
Y
-
S
A-
S
--
T
D
G
M
P
--
N
D
W
H
I
V
H
Y
A
-
T
R
A
I
G
G
V
G
L
I
M
Q
E
A
T
A
V
E
S
---
R
G
R
I
T
---
D
-
H
--
D
--
L
-
G
I
W
N
-
D
E
Q
V
K
E
L
K
K
I
V
D
I
C
K
A
N
G
A
V
M
G
I
Q
L
A
H
A
G
R
K
C
N
I
S
Y
---------------
E
D
V
V
G
P
S
P
I
K
---
A
---
G
--------------
D
---------------
R
Y
K
L
P
R
E
L
S
V
E
E
I
K
-
S
I
V
K
A
F
G
E
A
A
K
R
A
-
N
L
A
G
Y
D
V
V
E
I
H
A
A
H
G
Y
-
L
-
I
H
E
F
L
S
P
L
S
N
K
R
K
D
-
E
Y
G
N
-
S
I
E
N
R
A
R
F
L
I
E
V
I
D
E
V
R
K
N
W
P
----
E
N
K
P
I
F
V
R
V
S
A
D
-
D
Y
M
--
E
--
G
G
I
--
N
-
I
-
D
M
----
M
V
E
Y
I
N
M
I
K
--
D
------
K
V
D
L
I
D
V
S
S
G
G
L
L
N
V
D
-----------------------------------
I
N
L
Y
P
G
Y
Q
V
K
Y
A
E
T
I
K
K
R
C
--
N
I
K
T
S
A
V
G
L
I
T
T
Q
E
L
A
E
E
I
L
S
N
E
-
R
A
D
L
V
A
L
G
R
E
L
L
R
N
P
Y
W
V
L
H
T
Y
T
S
K
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
HHSearch
87.33
25%
-96
- C4 -
1Z41
4
NAMA_BACSU
A:
[2-329]
-------
A
R
K
L
F
T
P
I
T
I
K
-
D
M
T
L
K
N
R
I
V
M
S
P
--
M
C
M
Y
-
S
SH
E
--
K
D
G
K
L
--
T
P
F
H
M
A
H
Y
I
-
S
R
A
I
G
Q
V
G
L
I
I
V
E
A
S
A
V
N
P
---
Q
G
R
I
T
---
D
-
Q
--
D
--
L
-
G
I
W
S
-
D
E
H
I
E
G
F
A
K
L
T
E
Q
V
K
E
Q
G
S
K
I
G
I
Q
L
A
H
A
G
R
K
A
E
L
E
G
----------------
D
I
F
A
P
S
A
I
A
---
F
---
D
--------------
E
---------------
Q
S
A
T
P
V
E
M
S
A
E
K
V
K
-
E
T
V
Q
E
F
K
Q
A
A
A
R
A
-
K
E
A
G
F
D
V
I
E
I
H
A
A
H
G
Y
-
L
-
I
H
E
F
L
S
P
L
S
N
H
R
T
D
-
E
Y
G
G
-
S
P
E
N
R
Y
R
F
L
R
E
I
I
D
E
V
K
Q
V
W
------
D
G
P
L
F
V
R
V
S
A
S
-
D
Y
T
--
D
--
K
G
L
--
D
-
I
-
A
D
----
H
I
G
F
A
K
W
M
K
-
E
Q
------
G
V
D
L
I
D
C
S
S
G
A
L
V
H
A
D
-----------------------------------
I
N
V
F
P
G
Y
Q
V
S
F
A
E
K
I
R
E
Q
A
--
D
M
A
T
G
A
V
G
M
I
T
D
G
S
M
A
E
E
I
L
Q
N
G
-
R
A
D
L
I
F
I
G
R
E
L
L
R
D
P
F
F
A
R
T
A
A
K
Q
L
N
T
E
I
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
HHSearch
87.13
23%
-82
- C4 -
1O94
2
DHTM_METME
A:
[4-369]
-----
P
K
H
D
I
L
F
E
P
I
Q
I
G
-
P
K
T
L
R
N
R
F
Y
Q
V
P
--
H
C
I
G
-
A
--
G
--
S
D
K
----
P
G
F
Q
S
A
H
R
S
-
V
K
A
E
G
G
W
A
A
L
N
T
E
Y
C
S
I
N
P
---
E
S
D
D
T
H--
R
-
L
--
S
--
A
R
I
-
W
D
-
E
G
D
V
R
N
L
K
A
M
T
D
E
V
H
K
Y
G
A
L
A
G
V
E
L
W
Y
G
G
A
H
A
P
N
M
E
S
-------------
R
A
T
P
R
G
P
S
Q
Y
A
---
S
---
E
--------------
F
E--------------
T
L
S
Y
C
K
E
M
D
L
S
D
I
A
-
Q
V
Q
Q
F
Y
V
D
A
A
K
R
S
-
R
D
A
G
F
D
I
V
Y
V
Y
G
A
H
S
Y
-
L
-
P
L
Q
F
L
N
P
Y
Y
N
K
R
T
D
-
K
Y
G
G
-
S
L
E
N
R
A
R
F
W
L
E
T
L
E
K
V
K
H
A
V
G
----
S
D
C
A
I
A
T
R
F
G
V
D
-
T
V
Y
G-
P
--
G
Q
I
--
E
-
A
E
V
D
----
G
Q
K
F
V
E
M
A
D
-
S
-------
L
V
D
M
W
D
I
T
I
G
D
I
A
E
W
G
E
---
D
----------
A
G
P
----------------
S
R
F
Y
Q
Q
G
H
T
I
P
W
V
K
L
V
K
Q
V
S
--
K
K
P
V
L
G
V
G
R
Y
T
D
P
E
K
M
I
E
I
V
T
K
G
-
Y
A
D
I
I
G
C
A
R
P
S
I
A
D
P
F
L
P
Q
K
V
E
Q
G
R
Y
D
D
I
R
V
C
I
G
C
N
V
-
C
I
S
R
W
E
--
I
G
G
P
P
M
I
C
T
Q
N
A
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
Fugue
87.04
25%
-91
- C4 -
3K30
3
?
A:
[7-690]
---
V
A
A
P
Y
D
V
L
F
E
P
V
Q
I
G
-
P
F
T
T
K
N
R
F
Y
Q
V
P
--
H
C
N
G
-
M
--
G
--
Y
R
D
----
P
S
A
Q
A
S
M
R
K
-
I
K
A
E
G
G
W
S
A
V
C
T
E
Q
V
E
I
H
A
---
T
S
D
I
A
---
P
-
F
--
I
E
L
R
-
I
-
W
D
-
D
Q
D
L
P
A
L
K
R
I
A
D
A
I
H
E
G
G
G
L
A
G
I
E
L
A
H
N
G
M
N
A
P
N
Q
L
S
-------------
R
E
T
P
L
G
P
G
H
L
P
VAP
D
---
T
--------------
I
---------------
A
P
I
Q
A
R
A
M
T
K
Q
D
I
D
-
D
L
R
R
W
H
R
N
A
V
R
R
S
-
I
E
A
G
Y
D
I
V
Y
V
Y
G
A
H
G
Y
S
G
-
V
H
H
F
L
S
K
R
Y
N
Q
R
T
D
-
E
Y
G
G
-
S
L
E
N
R
M
R
L
L
R
E
L
L
E
D
T
L
D
E
C
A
----
G
R
A
A
V
A
C
R
I
T
V
E
-
E
E
I
--
D
--
G
G
I
--
T
-
R
-
E
D
----
I
E
G
V
L
R
E
L
G
E
--------
L
P
D
L
W
D
F
A
M
G
S
--------
W
E
G
D
S
V
T
----
S
R
F
A
P
E
G
R
Q
E
E
F
V
A
G
--------------------
L
K
K
L
T
--
T
K
P
V
V
G
V
G
R
F
T
S
P
D
A
M
V
R
Q
I
K
A
G
I
L
-
D
L
I
G
A
A
R
P
S
I
A
D
P
F
L
P
N
K
I
R
D
G
R
L
N
L
I
R
E
C
I
G
C
N
I
-
C
V
S
G
D
L
--
T
--
M
S
-
P
I
R
C
T
Q
N
P
SMGEEWRRGWHPERIRAKESD
A
R
V
L
V
V
G
AG
P
S
G
L
E
A
A
R
A
L
G
V
R
GYD
V
V
L
A
E
AGRDLG
G
R
V
T
Q
E
S
A
LPGLSAWG
R
V
K
E
Y
R
E
A
V
L
A
E
LPN
V
E
I
Y
R
E
S
P
M
T
G
D
D
I
V
E
F
GFE
H
V
I
T
AT
G
A
T
W
R
TDGVARFHTTALPIAEG
M
Q
V
L
G
P
D
D
L
F
A
GRLPDGK
K
V
V
V
Y
D
DDHYY
L
G
G
V
V
A
E
L
L
A
Q
K
GYE
V
S
I
V
T
PGAQVSSWTNNTFE
V
N
R
I
Q
R
R
L
I
E
N
GVARVTDHAVVAVGAG
G
V
T
V
R
D
TYAS
I
E
R
E
L
E
C
D
A
V
V
M
V
T
A
R
L
P
RE
E
L
Y
L
D
L
V
A
R
R
D
A
GEIA
S
V
R
G
I
G
DAWAPGT
I
A
A
A
V
W
S
G
R
R
A
A
E
E
FDAVLPSNDEVP
F
R
R
E
V
T
QLA
57
HHSearch
84.65
24%
-83
- C4 -
3K30
2
?
A:
[7-371]
---
V
A
A
P
Y
D
V
L
F
E
P
V
Q
I
G
-
P
F
T
T
K
N
R
F
Y
Q
V
P
--
H
C
N
G
-
M
--
G
--
Y
R
D
----
P
S
A
Q
A
S
M
R
K
-
I
K
A
E
G
G
W
S
A
V
C
T
E
Q
V
E
I
H
A
---
T
S
D
I
A
---
P
F
I
--
E
--
L
R
I
-
W
D
-
D
Q
D
L
P
A
L
K
R
I
A
D
A
I
H
E
G
G
G
L
A
G
I
E
L
A
H
N
G
M
N
A
P
N
Q
L
S
-------------
R
E
T
P
L
G
P
G
H
L
P
---
V
APD
T
--------------
I
---------------
A
P
I
Q
A
R
A
M
T
K
Q
D
I
D
-
D
L
R
R
W
H
R
N
A
V
R
R
S
-
I
E
A
G
Y
D
I
V
Y
V
Y
G
A
H
G
Y
-
S
G
V
H
H
F
L
S
K
R
Y
N
Q
R
T
D
-
E
Y
G
G
-
S
L
E
N
R
M
R
L
L
R
E
L
L
E
D
T
L
D
E
C
A
----
G
R
A
A
V
A
C
R
I
T
V
E
-
E
E
I
--
D
--
G
G
I
--
T
-
R
-
E
D
----
I
E
G
V
L
R
E
L
G
-
E
L
-------
P
D
L
W
D
F
A
M
G
S
W
E
G
D
S
V
----------------
T
S
----------------
R
F
A
P
E
G
R
Q
E
E
F
V
A
G
L
K
K
L
T
--
T
K
P
V
V
G
V
G
R
F
T
S
P
D
A
M
V
R
Q
I
K
A
G
-
I
L
D
L
I
G
A
A
R
P
S
I
A
D
P
F
L
P
N
K
I
R
D
G
R
L
N
L
I
R
E
C
I
G
C
N
I
-
C
V
S
G
D
L
--
T
M-
S
P
I
R
C
T
Q
N
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
84.40
23%
-85
- C4 -
1DJN
2
DHTM_METME
A:
[9-353]
----------
L
F
E
P
I
Q
I
G
-
P
K
T
L
R
N
R
F
Y
Q
V
P
--
H
C
I
G
-
A
--
G
--
S
D
-----
K
P
G
F
Q
S
A
H
R
S
V
K
A
E
G
G
W
A
A
L
N
T
E
Y
C
S
I
N
P
---
E
S
D
D
T
H
R
L
S
-
A
--
R
--
I
-
W
-
D
E
-
G
D
-
V
R
N
L
K
A
M
T
D
E
V
H
K
Y
G
A
L
A
G
V
E
L
W
Y
G
G
A
H
A
P
N
M
E
S
-------------
R
A
T
P
R
G
P
S
Q
Y
A
---
S
---
E
--------------
F
E--------------
T
L
S
Y
C
K
E
M
D
L
S
D
I
A
-
Q
V
Q
Q
F
Y
V
D
A
A
K
R
S
-
R
D
A
G
F
D
I
V
Y
V
Y
G
A
H
S
Y
-
L
-
P
L
Q
F
L
N
P
Y
Y
N
K
R
T
D
-
K
Y
G
G
-
S
L
E
N
R
A
R
F
W
L
E
T
L
E
K
V
K
H
A
V
G
----
S
D
C
A
I
A
T
R
F
G
V
--
D
T
V
--
Y
--
G
P
G
--
Q
-
I
-
E
A
----
E
V
D
G
Q
K
F
V
E
-----------------
M
A
D
S
L
V
D
M
W
D
I
T
I
G
D
I
------------
A
E
W
G
E
D
A
G
P
S
R
F
-----
Y
Q
Q
G
H
T
I
P
W
V
K
L
V
K
Q
V
S
--
K
K
P
V
L
G
V
G
R
Y
T
D
P
E
K
M
I
E
I
V
T
K
G
-
Y
A
D
I
I
G
C
A
R
P
S
I
A
D
P
F
L
P
Q
K
V
E
Q
G
R
Y
D
D
I
R
V
C
I
G
C
N
V
-
C
I
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
83.96
23%
-84
- C4 -
1DJQ
2
DHTM_METME
A:
[9-353]
----------
L
F
E
P
I
Q
I
G
-
P
K
T
L
R
N
R
F
Y
Q
V
P
--
H
A
I
G
-
A
--
G
--
S
D
-----
K
P
G
F
Q
S
A
H
R
S
V
K
A
E
G
G
W
A
A
L
N
T
E
Y
C
S
I
N
P
---
E
S
D
D
T
H
R
L
S
-
A
--
R
--
I
-
W
-
D
E
-
G
D
-
V
R
N
L
K
A
M
T
D
E
V
H
K
Y
G
A
L
A
G
V
E
L
W
Y
G
G
A
H
A
P
N
M
E
S
-------------
R
A
T
P
R
G
P
S
Q
Y
A
---
S
---
E
--------------
F
E--------------
T
L
S
Y
C
K
E
M
D
L
S
D
I
A
-
Q
V
Q
Q
F
Y
V
D
A
A
K
R
S
-
R
D
A
G
F
D
I
V
Y
V
Y
G
A
H
S
Y
-
L
-
P
L
Q
F
L
N
P
Y
Y
N
K
R
T
D
-
K
Y
G
G
-
S
L
E
N
R
A
R
F
W
L
E
T
L
E
K
V
K
H
A
V
G
----
S
D
C
A
I
A
T
R
F
G
V
--
D
T
V
--
Y
--
G
P
G
--
Q
-
I
-
E
A
----
E
V
D
G
Q
K
F
V
E
-----------------
M
A
D
S
L
V
D
M
W
D
I
T
I
G
D
I
------------
A
E
W
G
E
D
A
G
P
S
R
F
-----
Y
Q
Q
G
H
T
I
P
W
V
K
L
V
K
Q
V
S
--
K
K
P
V
L
G
V
G
R
Y
T
D
P
E
K
M
I
E
I
V
T
K
G
-
Y
A
D
I
I
G
C
A
R
P
S
I
A
D
P
F
L
P
Q
K
V
E
Q
G
R
Y
D
D
I
R
V
C
I
G
C
N
V
-
C
I
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
HHSearch
83.90
27%
-93
- C4 -
2R14
2
?
A:
[8-348]
-------
N
P
G
L
F
T
P
L
Q
L
G
-
S
L
S
L
P
N
R
V
I
M
A
P
--
L
T
R
S
-
R
--
T
--
P
D
S
V
P
--
G
R
L
Q
Q
I
Y
Y
G
-
Q
R
A
S
--
A
G
L
I
I
S
E
A
T
N
I
S
P
---
T
A
R
G
Y
---
V
-
Y
TP
G
--
I
-
W
--
T
-
D
A
Q
E
A
G
W
K
G
V
V
E
A
V
H
A
K
G
G
R
I
A
L
Q
L
W
H
V
G
R
V
S
H
E
L
V
Q
PD-----------
G
Q
Q
P
V
A
P
S
A
L
K
---
A
---
E
--------------
G
A
E
C
F
V
E
F
EDGTA
G
L
H
P
T
S
T
P
R
A
L
E
T
D
E
I
P
-
G
I
V
E
D
Y
R
Q
A
A
Q
R
A
-
K
R
A
G
F
D
M
V
E
V
H
A
A
N
A
C
-
L
-
P
N
Q
F
L
A
T
G
T
N
R
R
T
D
-
Q
Y
G
G
-
S
I
E
N
R
A
R
F
P
L
E
V
V
D
A
V
A
E
V
F
G
----
P
-
E
R
V
G
I
R
L
T
P
F
-
L
E
L
-----
F
G
L
--
T
-
D
-
D
E
P
E
A
M
A
F
Y
L
A
G
E
L
D
-
R
R
------
G
L
A
Y
L
H
F
N
E
P
D
-----------------------------------------
T
----
Y
P
E
G
F
R
E
Q
M
R
Q
R
F
--
K
G
G
L
I
Y
C
G
N
Y
-
D
A
G
R
A
Q
A
R
L
D
D
N
-
T
A
D
A
V
A
F
G
R
P
F
I
A
N
P
D
L
P
E
R
F
R
L
G
A
A
L
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
83.71
23%
-81
- C4 -
2TMD
2
DHTM_METME
A:
[9-353]
----------
L
F
E
P
I
Q
I
G
-
P
K
T
L
R
N
R
F
Y
Q
V
P
--
H
C
I
G
-
A
--
G
--
S
D
-----
K
P
G
F
Q
S
A
H
R
S
V
K
A
E
G
G
W
A
A
L
N
T
E
Y
C
S
I
N
P
---
E
S
D
D
T
H
R
L
S
-
A
--
R
--
I
-
W
-
D
E
-
G
D
-
V
R
N
L
K
A
M
T
D
E
V
H
K
Y
G
A
L
A
G
V
E
L
W
Y
G
G
A
H
A
P
N
M
E
S
-------------
R
A
T
P
R
G
P
S
Q
Y
A
---
S
---
E
--------------
F
E--------------
T
L
S
Y
C
K
E
M
D
L
S
D
I
A
-
Q
V
Q
Q
F
Y
V
D
A
A
K
R
S
-
R
D
A
G
F
D
I
V
Y
V
Y
G
A
H
S
Y
-
L
-
P
L
Q
F
L
N
P
Y
Y
N
K
R
T
D
-
K
Y
G
G
-
S
L
E
N
R
A
R
F
W
L
E
T
L
E
K
V
K
H
A
V
G
----
S
D
C
A
I
A
T
R
F
G
V
--
D
T
V
--
Y
--
G
P
G
--
Q
-
I
-
E
A
----
E
V
D
G
Q
K
F
V
E
-----------------
M
A
D
S
L
V
D
M
W
D
I
T
I
G
D
I
------------
A
E
W
G
E
D
A
G
P
S
R
F
-----
Y
Q
Q
G
H
T
I
P
W
V
K
L
V
K
Q
V
S
--
K
K
P
V
L
G
V
G
R
Y
T
D
P
E
K
M
I
E
I
V
T
K
G
-
Y
A
D
I
I
G
C
A
R
P
S
I
A
D
P
F
L
P
Q
K
V
E
Q
G
R
Y
D
D
I
R
V
C
I
G
C
N
V
-
C
I
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
83.58
23%
-86
- C4 -
1O94
2
DHTM_METME
A:
[9-353]
----------
L
F
E
P
I
Q
I
G
-
P
K
T
L
R
N
R
F
Y
Q
V
P
--
H
C
I
G
-
A
--
G
--
S
D
-----
K
P
G
F
Q
S
A
H
R
S
V
K
A
E
G
G
W
A
A
L
N
T
E
Y
C
S
I
N
P
---
E
S
D
D
T
H
R
L
S
-
A
--
R
--
I
-
W
-
D
E
-
G
D
-
V
R
N
L
K
A
M
T
D
E
V
H
K
Y
G
A
L
A
G
V
E
L
W
Y
G
G
A
H
A
P
N
M
E
S
-------------
R
A
T
P
R
G
P
S
Q
Y
A
---
S
---
E
--------------
F
E--------------
T
L
S
Y
C
K
E
M
D
L
S
D
I
A
-
Q
V
Q
Q
F
Y
V
D
A
A
K
R
S
-
R
D
A
G
F
D
I
V
Y
V
Y
G
A
H
S
Y
-
L
-
P
L
Q
F
L
N
P
Y
Y
N
K
R
T
D
-
K
Y
G
G
-
S
L
E
N
R
A
R
F
W
L
E
T
L
E
K
V
K
H
A
V
G
----
S
D
C
A
I
A
T
R
F
G
V
--
D
T
V
--
Y
--
G
P
G
--
Q
-
I
-
E
A
----
E
V
D
G
Q
K
F
V
E
-----------------
M
A
D
S
L
V
D
M
W
D
I
T
I
G
D
I
------------
A
E
W
G
E
D
A
G
P
S
R
F
-----
Y
Q
Q
G
H
T
I
P
W
V
K
L
V
K
Q
V
S
--
K
K
P
V
L
G
V
G
R
Y
T
D
P
E
K
M
I
E
I
V
T
K
G
-
Y
A
D
I
I
G
C
A
R
P
S
I
A
D
P
F
L
P
Q
K
V
E
Q
G
R
Y
D
D
I
R
V
C
I
G
C
N
V
-
C
I
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
82.45
23%
-85
- C4 -
1O95
2
DHTM_METME
A:
[9-353]
----------
L
F
E
P
I
Q
I
G
-
P
K
T
L
R
N
R
F
Y
Q
V
P
--
H
C
I
G
-
A
--
G
--
S
D
-----
K
P
G
F
Q
S
A
H
R
S
V
K
A
E
G
G
W
A
A
L
N
T
E
Y
C
S
I
N
P
---
E
S
D
D
T
H
R
L
S
-
A
--
R
--
I
-
W
-
D
E
-
G
D
-
V
R
N
L
K
A
M
T
D
E
V
H
K
Y
G
A
L
A
G
V
E
L
W
Y
G
G
A
H
A
P
N
M
E
S
-------------
R
A
T
P
R
G
P
S
Q
Y
A
---
S
---
E
--------------
F
E--------------
T
L
S
Y
C
K
E
M
D
L
S
D
I
A
-
Q
V
Q
Q
F
Y
V
D
A
A
K
R
S
-
R
D
A
G
F
D
I
V
Y
V
Y
G
A
H
S
Y
-
L
-
P
L
Q
F
L
N
P
Y
Y
N
K
R
T
D
-
K
Y
G
G
-
S
L
E
N
R
A
R
F
W
L
E
T
L
E
K
V
K
H
A
V
G
----
S
D
C
A
I
A
T
R
F
G
V
--
D
T
V
--
Y
--
G
P
G
--
Q
-
I
-
E
A
----
E
V
D
G
Q
K
F
V
E
-----------------
M
A
D
S
L
V
D
M
W
D
I
T
I
G
D
I
------------
A
E
W
G
E
D
A
G
P
S
R
F
-----
Y
Q
Q
G
H
T
I
P
W
V
K
L
V
K
Q
V
S
--
K
K
P
V
L
G
V
G
R
Y
T
D
P
E
K
M
I
E
I
V
T
K
G
-
Y
A
D
I
I
G
C
A
R
P
S
I
A
D
P
F
L
P
Q
K
V
E
Q
G
R
Y
D
D
I
R
V
C
I
G
C
N
V
-
C
I
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
HHSearch
81.45
25%
-89
- C4 -
2HSA
4
OPR3_SOLLC
B:
[17-366]
---------
P
L
F
S
P
Y
K
M
G
-
K
F
N
L
S
H
R
V
V
L
A
P
--
M
T
R
C
-
R
--
A
--
L
N
N
I
P
--
Q
A
A
L
G
E
Y
Y
E
-
Q
R
A
T
A
G
-
G
F
L
I
T
E
G
T
M
I
S
P
---
T
S
A
G
F
---
P
-
H
--
V
--
P
-
G
I
F
T
-
K
E
Q
V
R
E
W
K
K
I
V
D
V
V
H
A
K
G
A
V
I
F
C
Q
L
W
H
V
G
R
A
S
H
E
V
Y
Q
PA-----------
G
A
A
P
I
S
S
T
E
K
P
---
I
---
S
NR
W
R
I
L
M
PDG
T
H
--
G
---------------
I
Y
P
K
P
R
A
I
G
T
Y
E
I
S
-
Q
V
V
E
D
Y
R
R
S
A
L
N
A
-
I
E
A
G
F
D
G
I
E
I
H
G
A
H
G
Y
-
L
-
I
D
Q
F
L
K
D
G
I
N
D
R
T
D
-
E
Y
G
G
-
S
L
A
N
R
C
K
F
I
T
Q
V
V
Q
A
V
V
S
A
I
G
----
A
D
-
R
V
G
V
R
V
S
P
A
I
D
H
L
--
D
AM
D
S
N
--
P
-
L
-
S
L
----
G
L
A
V
V
E
R
L
N
-
K
I
Q
L
H
S
GS
K
L
A
Y
L
H
V
T
Q
P
R
Y
V
A
Y
G
Q
--
T
------------
E
A
G
----------------
R
L
G
S
E
E
E
E
A
R
L
M
R
T
L
R
N
A
Y
--
Q
G
T
F
I
C
S
G
G
Y
-
T
R
E
L
G
I
E
A
V
A
Q
G
-
D
A
D
L
V
S
Y
G
R
L
F
I
S
N
P
D
L
V
M
R
I
K
L
N
A
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
HHSearch
79.21
20%
-96
- C4 -
3L5A
3
?
A:
[22-373]
-----
Y
R
Y
K
P
L
L
Q
S
I
H
L
P
N
G
I
K
I
S
N
R
F
V
L
S
P
--
M
T
V
N
A
S
--
T
--
K
E
G
Y
I
--
T
K
A
D
L
A
Y
A
A
-
R
R
S
-
N
S
A
G
M
Q
V
T
G
A
A
Y
I
E
P
---
Y
G
K
L
F
---
E
-
Y
--
G
--
F
-
N
I
D
H
-
D
A
C
I
P
G
L
T
N
M
A
S
T
M
K
Q
H
G
S
L
A
I
I
Q
L
A
H
A
G
R
F
S
N
Q
A
I
L
N
------------
F
G
K
V
Y
G
P
S
P
M
T
---
L
---
H
S
-------------
P
---------------
I
E
H
V
V
I
A
M
S
H
E
K
I
N
-
S
I
I
Q
Q
Y
R
D
A
T
L
R
A
-
I
K
A
G
F
D
G
V
E
I
S
I
A
Q
R
L
-
L
-
I
Q
T
F
F
S
T
F
S
N
R
R
T
D
-
H
Y
G
A
D
S
L
K
N
R
A
R
L
C
L
E
V
M
R
A
V
Q
E
V
I
D
K
EAP
D
N
F
I
L
G
F
R
A
T
P
E
-
E
T
R
GS
D
--
L
G
Y
--
T
-
I
-
D
E
----
F
N
Q
L
I
D
W
V
M
-
D
V
S-----
N
I
Q
Y
L
A
I
A
S
W
G
R
H
I
Y
Q
N
-
T
S
R
------------------------------
T
P
-
G
D
H
F
G
R
P
V
N
Q
I
V
Y
E
H
L
AG
R
I
P
L
I
A
S
G
G
I
N
S
P
E
S
A
L
D
A
L
Q
-
H
-
A
-
D
M
V
G
M
S
S
P
F
V
T
E
P
D
F
V
H
K
L
A
E
Q
R
P
H
D
I
N
L
E
F
S
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
HHSearch
79.00
23%
-84
- C4 -
4E2B
6
?
A:
[4-359]
----
M
A
T
F
P
E
L
L
R
P
L
K
L
G
-
R
Y
T
L
R
N
R
I
I
M
A
P
--
L
T
R
C
Q
A
--
T
--
E
D
G
H
V
PR
T
E
S
M
L
K
Y
Y
E
-
D
R
A
S
--
A
G
L
I
I
A
E
A
T
M
V
Q
P
---
N
Y
T
G
F
---
L
-
T
--
E
--
P
-
G
I
Y
S
-
D
A
Q
I
E
E
W
R
K
I
V
D
A
V
H
K
K
G
G
L
I
F
L
Q
L
I
H
A
G
R
A
G
I
P
E
K
I
L
Q
QPKSDQDPL--
A
G
R
L
L
A
A
S
A
I
P
---
I
---
K
DHRIPAYFAASG
E
K
E
---------------
T
Y
G
V
P
E
E
L
T
D
D
E
V
R
N
G
I
I
P
L
F
V
E
G
A
K
N
A
I
F
K
A
G
F
D
G
V
E
I
H
G
A
N
G
Y
-
L
-
L
D
A
F
F
R
E
S
S
N
K
R
Q
S
G
P
Y
A
G
T
T
I
D
T
R
C
Q
L
I
Y
D
V
T
K
S
V
C
D
A
V
G
----
S
D
-
R
V
G
L
R
I
S
P
L
-
N
G
V
--
H
--
G
M
I
DS
N
P
E
-
A
L
----
T
K
H
L
C
K
K
I
E
-
P
L
------
S
L
A
Y
L
H
Y
L
R
G
D
M
V
N
Q
------------------------------------------
Q
I
G
D
V
V
A
W
V
R
G
S
Y
--
S
G
V
K
I
S
-
N
L
R
Y
D
F
E
E
A
D
Q
Q
I
R
E
G
-
K
V
D
A
V
A
F
G
A
K
F
I
A
N
P
D
L
V
E
R
A
Q
H
D
W
P
L
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------