@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv3797: (2016-05-23 )
MPEYDLEAVDKLPFSTPEKAQRYQTENYRGAMGLNWYLTDPTLQFIMAYYLRPDELAFAEPHLTRIGELTGGPVTRWAEETDRNPPRLERYDRWGHDISRVVLPESFIQSKRAVIEARQAVRDDAARAGVKPSLALFAADYLLNQADIGMACALATGGNMVRSLVTAYAPPDVREFVLGKLNSGEWDGEAAQLLTERAGGSDLGALETTATRSGDVWLLNGFKWFASNCAGEAFVVLAKPEGAPDSTRGVATFLVLRTRRDGSRNGVRIRRLKDKLGTRSVASGEIEFVDAEAFLLSGEPSADAGPSDGKGLTRMMELTNRLRLGTASFALGNARRALVESLCYAGQRRAFGGALIDKPLMRRKLAEMVVDVEAALAMVFDGFGAANHRQPRCLPQRIAVPVTKLKTCRLGITVASDAIEIHGGNGYIETWPVARLLRDAQVNTIWEGPDNILCLDVRRGIEQTRAHETLLARLRDAVSVSDDDDTTRLVSRRIEDLDAAITAWTKLDRQLAEARLFPLAQFMGDVYAGALLTEQAAWERATRGTDRKALVARLYARRYLADQGPLRGIDADCDEALQRFDELVAGAFTAEQT
Atome Classification :
(20 SA)
.........10........20...-----.....30..-----......40........50........60........70.-.-.......80........90........100........110.....-.--.120.....-.---.130---.-..-----..--..140..-.....150.......---.160..--...--..170.----------......180...-------------..------..-----------190.-.-----.....200.-..-....210-.--..-....220.......230........----240.----.----.....250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380--.---..---.....--390----.------........400.......410.......420.......430.......440.......450.......--------------460-.----.-.-....470.......480..-----.....490.......500...---....510......--------------.520.......530.......540-........550.......560-.......570.--......580.......590.----------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPEY
D
L
E
A
V
DKLPFST
P
E
K
A
Q
R
YQ-----TENYRG
A
M
G
-----
L
N
W
Y
LTD
P
T
L
Q
F
I
M
A
Y
YLRPDELAFAE
P
H
L
T
R
I
GELT-G-G-PVTR
W
A
E
ETDRN
P
P
R
L
E
R
Y
D
R
WGH
D
I
S
R
V
-VL
P
E
S
F
I
Q
S
K
R
A
V
I
E
A
-
R
--
Q
A
V
R
D
D
A
A
R-A---GVK
P
---
S
-
L
A
-----
L
F
--
A
A
D
Y
L
LN-QADI
G
M
-
A
C
A
LAT
G
G
---
N
M
V
R
S
L
--
V
T
A--YAPP
D
V
----------
R
E
F
V
L
GKLNSGE-------------WD------
G
E
-----------
A
A
Q
L
-
L
-----
T
E
RAGGSDL-G
A
-
L
E
TTATR-S--G
D
-
V
W
L
LN
G
F
K
W
F
A
SNCA-G
E
A
F
V
V
L
AK----PEGA----P----DSTR
G
V
A
T
F
L
V
L
R
TRRDGSRN
G
V
R
I
R
R
L
K
D
K
LGTRSVASG
E
I
E
F
V
DA
E
A
F
L
LSGEPSADAGPSDG
K
G
L
T
R
M
M
E
L
T
N
R
LRLGTASFALG
N
A
R
R
A
L
V
E
S
L
C
Y
AGQRRAFG
G
A
LI
D
K
P
L
M
R
R
K
L
A
E
M
V
V
D
V
E
A
A
L
A
M
V
F
D---G---FG---AANHR--Q------P------RCL
P
Q
R
IAVPVT
K
L
K
T
C
R
L
G
I
T
V
AS
D
A
I
E
I
HGGNG
Y
I
E
TW
P
V
A
R
L
L
R
DAQV
N
T
IWEGPD
N
I
L
C
L
D
V
R
R--------------
G
I
E
-
Q
----
T
-
R
-
A
H
E
T
L
L
A
R
L
R
D
AVSVSDD
D
-----
D
T
T
R
L
V
S
R
R
I
E
D
L
D
A
A
I
T
A
W
T
---
K
L
D
R
Q
L
A
E
A
R
L
F
P
--------------
L
A
Q
F
M
G
D
V
Y
A
G
A
L
L
T
E
Q
A
A
W
E
R
A--TRGT
D
R
K
A
L
V
A
R
L
Y
A
R
R
YLAD-QGPLRGIDA
D
C
--
D
E
A
L
Q
R
F
D
E
L
V
A
GAFTAEQT----------
70
Fugue
95.80
26%
-65
- C3 -
4Y9J
4
ACD11_CAEEL
A:
[1-592]
--------------
T
I
T
A
R
H
T
Q
Y
S
-----
H
A
K
T
G
G
F
S
Q
T
G
P
TL
H
N
P
Y
K
D
D
P
I
L
D
R
T
L
R
R
L
L
P
E
S
E
Y
M
R
V
A
A
D
L
S
K
F
G
D
R
I
-
T
-
S
-
E
V
E
H
L
G
R
Q
A
E
L
E
Q
P
R
L
E
H
Q
D
A
W
G
K
R
V
D
K
L
-
I
V
C
N
E
W
H
K
L
K
Q
I
C
A
E
-----
E
G
V
I
S
I
G
Y
E
-
D
---
S
V
D
P
---
F
-
V
R
-----
R
I
H
Q
V
A
K
L
F
L
F
-
S
P
S
A
G
L
V
S
C
P
M
A
M
T
D
---
G
A
V
K
T
L
--
T
S
L
NL
Y
G
K
H
K
L
----------
A
T
E
A
V
D
R
L
R
S
R
D
-------------
P
S
------
K
A
W
T
---------
S
G
Q
W
-
M
-----
T
E
K
K
G
G
S
D
V
-
A
G
G
C
D
T
Y
A
V
Q
-
I
D-
K
D
-
T
Y
R
L
H
G
Y
K
W
F
S
S
A
V
D
-
A
D
V
A
L
T
L
A
R
I
V
D
S
D
G
N
A
----
L
----
E
G
S
R
G
L
S
L
F
L
L
K
I
R
D
E
S
G
N
L
N
G
I
Q
M
V
R
L
K
N
K
L
G
T
K
Q
L
P
T
A
E
L
L
L
D
G
A
I
A
E
R
I
G
D
Q
---------
G
R
G
V
A
G
I
S
N
M
L
N
I
T
R
I
H
N
A
V
A
S
L
G
Y
M
R
R
I
I
S
L
A
R
D
Y
S
T
K
R
V
V
F
G
Q
T
Q
S
K
W
P
L
H
T
T
T
L
A
K
M
E
V
D
T
R
G
S
M
L
L
L
F
E
---
A
---
A
R
---
L
L
G
L
S
--
E
------
A
GKSS
D
V
E
A
M
M
L
R
L
I
T
P
V
L
K
L
Y
A
G
K
Q
A
V
P
M
V
S
E
G
I
E
C
F
G
G
Q
G
Y
M
E
D
T
G
L
P
T
L
L
R
D
A
Q
V
T
P
I
W
E
G
T
T
N
V
L
S
L
D
V
L
R
--------------
V
F
S
G
K
----
E
-
N
-
I
L
L
A
F
G
K
R
V
E
Q
L
L
G
N
T
K
T
E
-----
D
--
E
K
L
K
K
S
K
E
A
V
E
S
A
L
K
Q
L
Q
---
K
L
L
V
K
A
S
D
S
A
I
Q
G
ETRIDSV
A
R
H
----
I
A
F
T
I
A
R
I
Y
S
G
A
L
L
I
D
H
A
S
D
S
S
V
--
A
N
Q
S
D
I
E
V
------
A
Y
R
Y
C
C
E
-
Q
-
P
L
I
D
L
R
W
E
W
FA
S
E
R
V
K
A
D
R
E
I
V
F
D
N
F
T
--------------
69
Fugue
92.01
28%
-64
- C3 -
3DJL
2
AIDB_ECOLI
A:
[3-540]
-------------
W
Q
T
H
T
V
F
N
Q
P
I
-----
P
L
N
-----
N
-----
S
N
L
Y
L
S
D
G
A
L
C
E
A
V
T
R
E
----
G
A
G
W
D
S
D
F
L
A
S
I
G
Q
Q
L
-
G
T
A
-
E
S
L
E
L
G
R
L
A
N
V
N
P
P
E
L
L
R
Y
D
A
Q
G
R
R
L
D
D
V
-
R
F
H
P
A
W
H
L
L
M
Q
A
L
C
T
N
-
R
--
V
H
N
L
A
W
E
E
D
-
A
---
R
S
G
A
---
F
-
V
A
-----
R
A
--
A
R
F
M
L
H
A
-
Q
V
E
A
G
S
-
L
C
P
I
T
M
T
F
---
A
A
T
P
L
L
--
L
Q
M
----
L
P
A
P
----------
F
Q
D
W
T
T
P
L
L
S
D
R
-------------
Y
D
------
S
H
LLPGGQKR
G
L
L
I
G
M
G
-
M
-----
T
E
K
Q
G
G
S
D
V
-
M
S
-
N
T
T
R
A
E
R
-
L
--
E
D
G
S
Y
R
L
V
G
H
K
W
F
F
S
V
P
Q
-
S
D
A
H
L
V
L
A
Q
----
T
A
G
--------------
G
L
S
C
F
F
V
P
R
F
L
P
D
G
Q
R
N
A
I
R
L
E
R
L
K
D
K
L
G
N
R
S
N
A
S
C
E
V
E
F
Q
D
A
I
G
W
L
L
G
L
E
---------
G
E
G
I
R
L
I
L
K
M
G
G
M
T
R
F
D
C
A
L
G
S
H
A
M
M
R
R
A
F
S
L
A
I
Y
H
A
H
Q
R
H
V
F
G
N
P
L
I
Q
Q
P
L
M
R
H
V
L
S
R
M
A
L
Q
L
E
G
Q
T
A
L
L
F
R
---
L
---
A
R
---
A
W
D
R
R
AD
A
------
K
------
E
A
L
W
A
R
L
F
T
P
A
A
K
F
V
I
C
K
R
G
M
P
F
V
A
E
A
M
E
V
L
G
G
I
G
Y
C
E
E
S
E
L
P
R
L
Y
R
E
M
P
V
N
S
I
W
E
G
S
G
N
I
M
C
L
D
V
L
R
--------------
V
L
N
-
K
----
Q
A
G
-
V
Y
D
L
L
S
E
A
F
V
E
V
K
G
Q
D
------------------
R
Y
F
D
R
A
V
R
R
L
Q
---
Q
Q
L
R
K
P
A
E
E
L
G
R
E
--------------
I
T
H
Q
L
F
L
L
G
C
G
A
Q
M
L
K
Y
A
S
------------
P
P
M
A
Q
A
W
C
Q
V
M
L
D
T
R
-
G
G
V
R
L
S
-
E
Q
I
Q
--
N
D
L
L
L
R
A
T
G
G
V
C
------------------
49
HHSearch
89.21
29%
-67
- C3 -
3DJL
2
AIDB_ECOLI
A:
[9-520]
-----------------------------
F
N
Q
P
I
P
L
N
N
-----
S
N
L
Y
L
S
D
G
A
L
C
E
A
V
T
R
E
G
A
----
G
W
D
S
D
F
L
A
S
I
G
Q
Q
L
-
G
-
T
A
E
S
L
E
L
G
R
L
A
N
V
N
P
P
E
L
L
R
Y
D
A
Q
G
R
R
L
D
D
V
-
R
F
H
P
A
W
H
L
L
M
Q
A
L
C
T
N
-
R
---
V
H
N
L
A
W
E
E
D
A
---
R
S
G
A
---
F
-
V
A
R
A
A
R
F
M
L
--
H
A
Q
V
E
A
G
-
S
L
C
P
I
T
-
M
T
F
A
A
T
P
L
L
L
Q
M
L
P
A
P
F
---
Q
D
--
W
T
T
P
L
L
----------
S
D
R
Y
D
S
H
L
L
P
G
G
QKR
G
---------
L
L
------
I
-------------
G
M
G
-
M
-----
T
E
K
Q
G
G
S
D
V
-
M
S
-
N
T
T
R
A
E
R
-
L
E-
D
G
-
S
Y
R
L
V
G
H
K
W
F
F
S
V
P
Q
-
S
D
A
H
L
V
L
A
Q
----
T
A
G
--------------
G
L
S
C
F
F
V
P
R
F
L
P
D
G
Q
R
N
A
I
R
L
E
R
L
K
D
K
L
G
N
R
S
N
A
S
C
E
V
E
F
Q
D
A
I
G
W
L
L
G
-
L
E
--------
G
E
G
I
R
L
I
L
K
M
G
G
M
T
R
F
D
C
A
L
G
S
H
A
M
M
R
R
A
F
S
L
A
I
Y
H
A
H
Q
R
H
V
F
G
N
P
L
I
Q
Q
P
L
M
R
H
V
L
S
R
M
A
L
Q
L
E
G
Q
T
A
L
L
F
R
---
L
---
A
R
---
A
W
D
R
R
--
A
------
D
A
K
----
E
A
L
W
A
R
L
F
T
P
A
A
K
F
V
I
C
K
R
G
M
P
F
V
A
E
A
M
E
V
L
G
G
I
G
Y
C
E
E
S
E
L
P
R
L
Y
R
E
M
P
V
N
S
I
W
E
G
S
G
N
I
M
C
L
D
V
L
R
--------------
V
L
N
-
K
----
Q
-
A
G
V
Y
D
L
L
S
E
A
F
V
E
V
K
G
Q
D
-----------
R
Y
F
D
R
A
V
R
R
L
Q
Q
Q
L
R
----------
K
P
A
E
E
L
G
R
E
--------------
I
T
H
Q
L
F
L
L
G
C
G
A
Q
M
L
K
Y
A
S
P
-------------
P
M
A
Q
A
W
C
Q
V
M
L
D
T
-
R
G
G
----------------------------------------
50
HHSearch
88.70
30%
-67
- C3 -
5EZ3
5
?
A:
[38-547]
-----------------------------
T
N
Q
T
P
P
I
T
G
-----
T
N
A
Y
L
G
D
P
L
L
M
Q
I
A
A
R
F
-
P
K
----
E
L
H
T
E
L
E
Q
A
G
R
F
V
-
L
-
S
A
E
A
Q
D
L
A
R
L
A
N
T
E
L
P
K
L
R
T
H
D
R
Q
G
R
R
I
D
L
V
-
E
Y
H
P
A
Y
H
A
L
M
R
R
S
V
A
Q
-
G
---
L
H
S
S
I
W
E
D
N
P
LES
G
R
R
H
---
Q
--
A
-----
R
A
--
A
R
F
Y
L
T
A
-
Q
L
E
A
G
H
-
L
C
P
L
T
M
T
S
---
A
S
--
L
A
---
A
L
--
M
A
S
P
E
V
----------
Y
K
Q
W
S
P
A
V
L
S
R
K
YDFSQKPAFRKQ
G
V
T
------
L
-------------
G
M
G
-
M
-----
T
E
K
Q
G
G
T
D
V
-
R
A
-
N
A
T
R
A
E
P
-
A
I
-
G
G
-
A
W
R
L
T
G
H
K
W
F
M
S
A
P
M
-
S
D
A
F
L
T
L
A
Q
----
T
K
--------------
E
G
L
S
C
F
L
L
P
R
L
G
E
K
G
E
S
N
G
F
F
F
Q
R
L
K
D
K
L
G
N
R
S
N
A
S
S
E
V
E
F
D
G
A
L
G
Q
M
I
G
-
S
P
--------
G
E
G
V
K
T
I
M
D
M
V
T
L
T
R
L
D
C
A
V
A
S
A
G
L
M
R
S
G
L
A
E
A
V
H
H
S
R
H
R
H
V
F
G
K
P
L
V
E
Q
P
L
M
Q
R
V
L
A
D
M
A
L
D
V
A
G
A
T
A
L
S
M
R
---
L
---
A
R
---
A
F
D
M
A
--
A
------
S
D
R
A
---
E
A
A
F
A
R
S
M
T
P
V
V
K
Y
W
V
C
K
I
A
P
A
L
L
Y
E
A
M
E
C
L
G
G
N
G
Y
I
E
D
G
N
L
A
R
A
Y
R
E
A
P
V
N
A
I
W
E
G
S
G
N
V
M
A
L
D
V
A
R
--------------
V
L
S
-
R
----
A
-
P
A
L
F
D
G
V
L
D
W
I
S
G
Q
L
G
P
R
G
Q
G
-------------
T
I
D
V
L
R
A
A
L
--------
Q
L
T
E
T
D
Q
G
V
A
R
L
--------------
L
T
E
Q
L
A
F
A
A
A
A
A
E
L
R
Q
L
G
A
D
-------------
D
I
A
D
A
F
I
E
T
R
L
G
G
--------------------------------------------
48
HHSearch
88.12
24%
-60
- C3 -
4Y9J
4
ACD11_CAEEL
A:
[10-592]
------------------
S
H
A
K
T
G
-----
G
F
S
Q
T
G
P
T
L
-----
H
N
P
Y
K
D
D
P
I
L
D
R
T
L
R
R
L
L
P
E
S
E
Y
M
R
V
A
A
D
L
S
K
F
G
D
R
I
-
T
-
S
-
E
V
E
H
L
G
R
Q
A
E
L
E
Q
P
R
L
E
H
Q
D
A
W
G
K
R
V
D
K
L
-
I
V
C
N
E
W
H
K
L
K
Q
I
C
A
E
E
-
G
---
V
I
S
I
G
Y
E
D
S
V
---
D
P
F
V
---
R
R
I
H
-----
Q
V
--
A
K
L
F
L
F
S
-
P
S
A
G
L
V
-
S
C
P
M
A
M
T
D
---
G
A
V
K
T
L
T
S
L
N
L
--
Y
G
K
H
K
L
----------
A
T
E
A
V
D
R
L
R
S
R
D
PS
K
A
---------
W
T
------
S
-------------
G
Q
W
-
M
-----
T
E
K
K
G
G
S
D
V
-
A
G
G
C
D
T
Y
A
V
Q
-
I
D-
K
D
-
T
Y
R
L
H
G
Y
K
W
F
S
S
A
V
D
-
A
D
V
A
L
T
L
A
R
----
I
V
D
S
DG
N
A
L
----
E
G
S
R
G
L
S
L
F
L
L
K
I
R
D
E
S
G
N
L
N
G
I
Q
M
V
R
L
K
N
K
L
G
T
K
Q
L
P
T
A
E
L
L
L
D
G
A
I
A
E
R
I
G
-
D
Q
--------
G
R
G
V
A
G
I
S
N
M
L
N
I
T
R
I
H
N
A
V
A
S
L
G
Y
M
R
R
I
I
S
L
A
R
D
Y
S
T
K
R
V
V
F
G
Q
T
Q
S
K
W
P
L
H
T
T
T
L
A
K
M
E
V
D
T
R
G
S
M
L
L
L
F
E
---
A
---
A
R
---
L
L
G
L
S
--
E
A
GKSS
D
V
------
E
A
M
M
L
R
L
I
T
P
V
L
K
L
Y
A
G
K
Q
A
V
P
M
V
S
E
G
I
E
C
F
G
G
Q
G
Y
M
E
D
T
G
L
P
T
L
L
R
D
A
Q
V
T
P
I
W
E
G
T
T
N
V
L
S
L
D
V
L
R
--------------
V
F
S
-
G
----
K
-
E
N
I
L
L
A
F
G
K
R
V
E
Q
L
L
G
N
T
K
T
E
D
E
K
L
K
K
S
K
E
A
V
E
S
A
L
K
Q
L
Q
K
L
L
V
K
A
S
DSA
I
Q
G
E
T
R
I
D
S
V
A
R
H
--------------
I
A
F
T
I
A
R
I
Y
S
G
A
L
L
I
D
H
A
S
D
S
S
V
--
A
--
N
Q
S
D
I
E
V
A
Y
R
Y
C
C
E
Q
P
L
I
-
D
L
R
--
W
E
W
F
A
---
S
E
R
V
K
A
D
R
E
I
V
F
D
N
F
T
--------------
4
PsiBlast_PDB
88.07
26%
-57
- C3 -
4Y9J
4
ACD11_CAEEL
A:
[26-567]
--------------------------------------------
N
P
Y
K
D
D
P
I
L
D
R
T
L
R
R
L
L
P
E
S
E
Y
M
R
V
A
A
D
L
S
K
F
G
D
R
I
-
T
-
S
-
E
V
E
H
L
G
R
Q
A
E
L
E
Q
P
R
L
E
H
Q
D
A
W
G
K
R
V
D
K
L
-
I
V
C
N
E
W
H
K
L
K
Q
--
I
C
A
-
E
--
E
G
V
I
S
I
G
Y
E
-
D
---
S
V
D
P
F
V
R
R
-
I
H
-----
Q
V
--
A
K
L
F
L
F
S
-
P
S
A
G
L
V
-
S
C
P
M
A
M
T
D
---
G
A
V
K
T
L
--
T
S
L
NL
Y
G
K
H
K
L
----------
A
T
E
A
V
D
R
L
R
S
R
D
PS
K
A
---------
W
--------
T
-----------
S
G
Q
W
-
M
-----
T
E
K
K
G
G
S
D
V
A
G
G
-
C
D
T
Y
A
V
Q
I
D
--
K
D
-
T
Y
R
L
H
G
Y
K
W
F
S
S
A
V
D
-
A
D
V
A
L
T
L
A
R
I
V
D
S
D
G
N
A
----
L
----
E
G
S
R
G
L
S
L
F
L
L
K
I
R
D
E
S
G
N
L
N
G
I
Q
M
V
R
L
K
N
K
L
G
T
K
Q
L
P
T
A
E
L
--------
L
L
D
G
A
I
A
E
R
I
G
-
D
Q
G
R
G
V
A
G
I
S
N
M
L
N
I
T
R
I
H
N
A
V
A
S
L
G
Y
M
R
R
I
I
S
L
A
R
D
Y
S
T
K
R
V
V
F
G
Q
T
Q
S
K
W
P
L
H
T
T
T
L
A
K
M
E
V
D
T
R
G
S
M
L
L
L
F
E
---
A
A
R
L
L
G
L
S
E
A
G
K
S
S
--
D
------
V
------
E
A
M
M
L
R
L
I
T
P
V
L
K
L
Y
A
G
K
Q
A
V
P
M
V
S
E
G
I
E
C
F
G
G
Q
G
Y
M
E
D
T
G
L
P
T
L
L
R
D
A
Q
V
T
P
I
W
E
G
T
T
N
V
L
S
L
D
V
L
R
V
F
SGKE
N
I
L
L
A
F
G
K
R
V
E
-
Q
L
L
G
N
T
-
K
-
T
E
D
E
K
L
K
K
S
K
E
A
V
----
E
S
-----
A
L
K
Q
L
Q
K
L
L
V
K
A
S
D
S
A
I
Q
G
E
T
---
R
I
D
-
S
V
A
R
H
I
A
F
T
--------------
I
A
R
----
I
Y
S
G
A
L
L
I
D
H
A
S
D
S
S
V
--
A
N
Q
S
D
I
E
V
------
A
Y
R
Y
C
C
E
-
Q
-
P
L
---------------------------------------
5
PsiBlast_PDB
86.32
26%
-54
- C3 -
4Y9L
2
ACD11_CAEEL
A:
[26-567]
--------------------------------------------
N
P
Y
K
D
D
P
I
L
D
R
T
L
R
R
L
L
P
E
S
E
Y
M
R
V
A
A
D
L
S
K
F
G
D
R
I
-
T
-
S
-
E
V
E
H
L
G
R
Q
A
E
L
E
Q
P
R
L
E
H
Q
D
A
W
G
K
R
V
D
K
L
-
I
V
C
N
E
W
H
K
L
K
Q
--
I
C
A
-
E
--
E
G
V
I
S
I
G
Y
E
-
D
---
S
V
D
P
F
V
R
R
-
I
H
-----
Q
V
--
A
K
L
F
L
F
S
-
P
S
A
G
L
V
-
S
C
P
M
A
M
T
D
---
G
A
V
K
T
L
--
T
S
L
NL
Y
G
K
H
K
L
----------
A
T
E
A
V
D
R
L
R
S
R
D
PSK
A
---------
W
--------
T
-----------
S
G
Q
W
-
M
-----
T
E
K
K
G
G
S
D
V
A
G
G
-
C
D
T
Y
A
V
Q
I
D
--
K
D
-
T
Y
R
L
H
G
Y
K
W
F
S
S
A
V
D
-
A
D
V
A
L
T
L
A
R
I
V
D
S
D
G
N
A
----
L
----
E
G
S
R
G
L
S
L
F
L
L
K
I
R
D
E
S
G
N
L
N
G
I
Q
M
V
R
L
K
N
K
L
G
T
K
Q
L
P
T
A
E
L
--------
L
L
D
G
A
I
A
E
R
I
G
-
D
Q
G
R
G
V
A
G
I
S
N
M
L
N
I
T
R
I
H
N
A
V
A
S
L
G
Y
M
R
R
I
I
S
L
A
R
D
Y
S
T
K
R
V
V
F
G
Q
T
Q
S
K
W
P
L
H
T
T
T
L
A
K
M
E
V
D
T
R
G
S
M
L
L
L
F
E
---
A
A
R
L
L
G
L
S
E
A
G
K
S
S
--
D
------
V
------
E
A
M
M
L
R
L
I
T
P
V
L
K
L
Y
A
G
K
Q
A
V
P
M
V
S
E
G
I
E
C
F
G
G
Q
G
Y
M
E
D
T
G
L
P
T
L
L
R
D
A
Q
V
T
P
I
W
E
G
T
T
N
V
L
S
L
D
V
L
R
V
F
SGK
E
N
I
L
L
A
F
G
K
R
V
E
-
Q
L
L
G
N
T
-
K
-
T
E
D
E
K
L
K
K
S
K
E
A
V
----
E
S
-----
A
L
K
Q
L
Q
K
L
L
V
K
A
S
D
S
A
I
Q
G
E
T
---
R
I
D
-
S
V
A
R
H
I
A
F
T
--------------
I
A
R
----
I
Y
S
G
A
L
L
I
D
H
A
S
D
S
S
V
--
A
N
Q
S
D
I
E
V
------
A
Y
R
Y
C
C
E
-
Q
-
P
L
---------------------------------------
72
Fugue
74.82
20%
-57
- C3 -
2UXW
4
ACADV_HUMAN
A:
[21-607]
--------------------------------
Q
S
M
S
F
A
-----
V
G
M
F
K
G
Q
L
T
T
D
Q
V
F
P
Y
---
P
S
V
L
---
N
E
E
Q
T
Q
F
L
K
E
L
-
V
-
E
-
P
V
S
R
F
F
E
E
-
V
N
D
P
A
K
N
D
A
L
E
M
V
E
E
T
T
W
Q
G
-
L
K
E
L
G
A
F
--------------
G
L
Q
V
P
S
E
L
-
G
---
G
V
G
L
C--
N
-
T
Q
-----
Y
A
--
R
L
V
E
I
V
G
-
M
H
D
L
G
V
-
G
I
T
L
G
A
H
Q
---
S
I
G
F
K
G
--
I
L
L
--
F
G
T
K
A
Q
----------
K
E
K
Y
L
P
K
L
A
S
G
E
-------------
T
--------
V
-----------
A
A
F
C
-
L
-----
T
E
P
S
S
G
S
D
A
-
A
S
-
I
R
T
S
A
V
P
-
S
PC
G
K
-
Y
Y
T
L
N
G
S
K
L
W
I
S
N
G
G
L
A
D
I
F
T
V
F
A
K
----
T
P
V
T
----
D
PATG
A
V
K
E
K
I
T
A
F
V
V
E
R
G
F
-----
G
G
I
T
H
G
P
P
E
K
K
M
G
I
K
A
S
N
T
A
E
V
F
F
D
G
V
R
V
P
------
S
E
N
V
L
G
E
V
G
S
G
F
K
V
A
M
H
I
L
N
N
G
R
F
G
M
A
A
A
L
A
G
T
M
R
G
I
I
A
K
A
V
D
H
A
T
N
R
T
Q
F
G
E
K
I
H
N
F
G
L
I
Q
E
K
L
A
R
M
V
M
L
Q
Y
V
T
E
S
M
A
Y
M
---
V
---
S
A
---
N
M
D
Q
G
--
A
------
T
---------
D
F
Q
I
E
A
A
I
S
K
I
F
G
S
E
A
A
W
K
V
T
D
E
C
I
Q
I
M
G
G
M
G
F
M
K
E
P
G
V
E
R
V
L
R
D
L
R
I
F
R
I
F
E
G
T
N
D
I
L
R
L
F
V
A
L
--------------
Q
G
C
-
M
----
D
-
K
-
G
K
E
L
S
G
L
G
S
A
L
K
N
P
F
G
S
G
L
-----
S
L
S
G
L
V
H
P
E
L
S
R
S
G
E
L
A
V
R
A
L
---
E
Q
F
A
T
V
V
E
A
K
L
I
K
HKKGIVNE
Q
F
L
L
Q
R
L
A
D
G
A
I
D
L
Y
A
M
V
V
V
L
S
R
A
S
R
S
L
S
E
G
H
P
T
A
Q
H
E
K
M
L
C
D
T
W
C
I
E
A
A
A
R
I
R
E
G
M
A
A
L
Q
S
D
P
--
W
Q
Q
E
L
Y
R
N
F
K
S
I
S
K
A
L
V
E
R
G
GVVTSNPLGF
2
PsiBlast_PDB
74.77
33%
-61
- C3 -
3DJL
2
AIDB_ECOLI
A:
[65-450]
------------------------------------------------------------------------------------------------
N
P
P
E
L
L
R
Y
D
A
Q
G
R
R
L
D
D
V
-
R
F
H
P
A
W
H
L
L
M
Q
A
L
C
T
N
-
R
VH
N
L
A
W
E
E
D
A
R
-
S
---
G
------
A
-
F
V
-----
A
R
--
A
A
R
F
M
L
H
A
Q
V
E
A
G
S
-
L
C
P
I
-
T
M
T
---
F
A
A
T
P
L
--
L
L
Q
--
M
L
P
A
P
F
----------
Q
D
W
T
T
-
P
L
L
S
D
R
-------------
Y
D
SHLLPG
G
Q
-----------
K
R
G
L
-
L
I
G
M
G
M
T
E
K
Q
G
G
S
D
V
-
M
S
-
N
T
T
R
A
E
R
-
L
--
E
D
G
S
Y
R
L
V
G
H
K
W
F
F
S
V
P
Q
-
S
D
A
H
L
V
L
A
Q
----
T
A
G
--------------
G
L
S
C
F
F
V
P
R
F
L
P
D
G
Q
R
N
A
I
R
L
E
R
L
K
D
K
L
G
N
R
S
N
A
S
C
E
V
E
F
Q
D
A
I
G
W
L
L
G
L
E
---------
G
E
G
I
R
L
I
L
K
M
G
G
M
T
R
F
D
C
A
L
G
S
H
A
M
M
R
R
A
F
S
L
A
I
Y
H
A
H
Q
R
H
V
F
G
N
P
L
I
Q
Q
P
L
M
R
H
V
L
S
R
M
A
L
Q
L
E
G
Q
T
A
L
L
F
R
---
L
---
A
R
---
A
W
D
R
R
--
A
D
A
----
K
------
E
A
L
W
A
R
L
F
T
P
A
A
K
F
V
I
C
K
R
G
M
P
F
V
A
E
A
M
E
V
L
G
G
I
G
Y
C
E
E
S
E
L
P
R
L
Y
R
E
M
P
V
N
S
I
W
E
G
S
G
N
I
M
C
L
D
V
L
R
--------------
V
L
N
-
K
----
Q
-
A
-
G
V
Y
D
L
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
74.58
33%
-62
- C3 -
3U33
10
AIDB_ECOLI
L:
[65-450]
------------------------------------------------------------------------------------------------
N
P
P
E
L
L
R
Y
D
A
Q
G
R
R
L
D
D
V
-
R
F
H
P
A
W
H
L
L
M
Q
A
L
C
T
N
-
R
VH
N
L
A
W
E
E
D
A
R
-
S
---
G
------
A
-
F
V
-----
A
R
--
A
A
R
F
M
L
H
A
Q
V
E
A
G
S
-
L
C
P
I
-
T
M
T
---
F
A
A
T
P
L
--
L
L
Q
--
M
L
P
A
P
F
----------
Q
D
W
T
T
-
P
L
L
S
D
R
-------------
Y
D
SHLLPG
G
Q
-----------
K
R
G
L
-
L
IGMGM
T
E
K
Q
G
G
S
D
V
-
M
S
-
N
T
T
R
A
E
R
-
L
--
E
D
G
S
Y
R
L
V
G
H
K
W
F
F
S
V
P
Q
-
S
D
A
H
L
V
L
A
Q
----
T
A
G
--------------
G
L
S
C
F
F
V
P
R
F
L
P
D
G
Q
R
N
A
I
R
L
E
R
L
K
D
K
L
G
N
R
S
N
A
S
C
E
V
E
F
Q
D
A
I
G
W
L
L
G
L
E
---------
G
E
G
I
R
L
I
L
K
M
G
G
M
T
R
F
D
C
A
L
G
S
H
A
M
M
R
R
A
F
S
L
A
I
Y
H
A
H
Q
R
H
V
F
G
N
P
L
I
Q
Q
P
L
M
R
H
V
L
S
R
M
A
L
Q
L
E
G
Q
T
A
L
L
F
R
---
L
---
A
R
---
A
W
D
R
R
--
A
DA----
K
------
E
A
L
W
A
R
L
F
T
P
A
A
K
F
V
I
C
K
R
G
M
P
F
V
A
E
A
M
E
V
L
G
G
I
G
Y
C
E
E
S
E
L
P
R
L
Y
R
E
M
P
V
N
S
I
W
E
G
S
G
N
I
M
C
L
D
V
L
R
--------------
V
L
N
-
K
----
Q
-
A
-
G
V
Y
D
L
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
74.35
31%
-51
- C3 -
5EZ3
6
?
C:
[33-467]
------------------------KTHEV
T
N
Q
T
P
P
I
T
G
-----
T
N
A
Y
L
G
D
P
L
L
M
Q
I
A
A
R
F
--
P
K
E
L
---
H
T
E
L
E
Q
A
G
R
F
V
L
S
-
A
-
E
A
Q
D
L
A
R
L
A
N
T
E
L
P
K
L
R
T
H
D
R
Q
G
R
R
I
D
L
V
E
Y
H
P
A
Y
H
A
L
M
R
R
S
V
A
Q
G
L
H
--
S
S
I
W
E
D
N
P
L
-
E
---
S
G
R
R
---
H
-
Q
A
-----
R
A
--
A
R
F
Y
L
T
A
-
Q
L
E
A
G
H
-
L
C
P
L
T
M
T
S
---
A
---
S
L
--
A
A
L
--
M
A
S
P
E
V
YKQWSPAVLS
R
K
Y
D
F
S
Q
K
P
A
F
R
-------------
K
Q
------
G
V
-----------
T
L
G
M
G
M
-----
T
E
K
Q
G
G
T
D
V
-
R
A
-
N
A
T
R
A
E
P
-
A
I-
G
G
-
A
W
R
L
T
G
H
K
W
F
M
S
A
P
M
-
S
D
A
F
L
T
L
A
Q
------------------
T
K
E
G
L
S
C
F
L
L
P
R
L
G
E
K
G
E
S
N
G
F
F
F
Q
R
L
K
D
K
L
G
N
R
S
N
A
S
S
E
V
E
F
-
D
G
A
L
G
Q
M
I
G
S
P
--------
G
E
G
V
K
T
I
M
D
M
V
T
L
T
R
L
D
C
A
V
A
S
A
G
L
M
R
S
G
L
A
E
A
V
H
H
S
R
H
R
H
V
F
G
K
P
L
V
E
Q
P
L
M
Q
R
V
L
A
D
M
A
L
D
V
A
G
A
T
A
L
S
M
R
LAR
A
---
F
D
---
M
A
A
S
D
--
R
------
A
------
E
A
A
F
A
R
S
M
T
P
V
V
K
Y
W
V
C
K
I
A
P
A
L
L
Y
E
A
M
E
C
L
G
G
N
G
Y
I
E
D
G
N
L
A
R
A
Y
R
E
A
P
V
N
A
I
W
E
G
S
G
N
V
M
A
L
D
V
A
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
74.11
33%
-62
- C3 -
3U33
4
AIDB_ECOLI
D:
[65-450]
------------------------------------------------------------------------------------------------
N
P
P
E
L
L
R
Y
D
A
Q
G
R
R
L
D
D
V
-
R
F
H
P
A
W
H
L
L
M
Q
A
L
C
T
N
-
R
VH
N
L
A
W
E
E
D
A
R
-
S
---
G
------
A
-
F
V
-----
A
R
--
A
A
R
F
M
L
H
A
Q
V
E
A
G
S
-
L
C
P
I
-
T
M
T
---
F
A
A
T
P
L
--
L
L
Q
--
M
L
P
A
P
F
----------
Q
D
W
T
T
-
P
L
L
S
D
R
-------------
Y
D
SHLLPG
G
Q
-----------
K
R
G
L
-
L
IGMGM
T
E
K
Q
G
G
S
D
V
-
M
S
-
N
T
T
R
A
E
R
-
L
--
E
D
G
S
Y
R
L
V
G
H
K
W
F
F
S
V
P
Q
-
S
D
A
H
L
V
L
A
Q
----
T
A
G
--------------
G
L
S
C
F
F
V
P
R
F
L
P
D
G
Q
R
N
A
I
R
L
E
R
L
K
D
K
L
G
N
R
S
N
A
S
C
E
V
E
F
Q
D
A
I
G
W
L
L
G
L
E
---------
G
E
G
I
R
L
I
L
K
M
G
G
M
T
R
F
D
C
A
L
G
S
H
A
M
M
R
R
A
F
S
L
A
I
Y
H
A
H
Q
R
H
V
F
G
N
P
L
I
Q
Q
P
L
M
R
H
V
L
S
R
M
A
L
Q
L
E
G
Q
T
A
L
L
F
R
---
L
---
A
R
---
A
W
D
R
R
--
A
DA----
K
------
E
A
L
W
A
R
L
F
T
P
A
A
K
F
V
I
C
K
R
G
M
P
F
V
A
E
A
M
E
V
L
G
G
I
G
Y
C
E
E
S
E
L
P
R
L
Y
R
E
M
P
V
N
S
I
W
E
G
S
G
N
I
M
C
L
D
V
L
R
--------------
V
L
N
-
K
----
Q
-
A
-
G
V
Y
D
L
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
73.88
33%
-62
- C3 -
3U33
4
AIDB_ECOLI
B:
[65-450]
------------------------------------------------------------------------------------------------
N
P
P
E
L
L
R
Y
D
A
Q
G
R
R
L
D
D
V
-
R
F
H
P
A
W
H
L
L
M
Q
A
L
C
T
N
-
R
VH
N
L
A
W
E
E
D
A
R
-
S
---
G
------
A
-
F
V
-----
A
R
--
A
A
R
F
M
L
H
A
Q
V
E
A
G
S
-
L
C
P
I
-
T
M
T
---
F
A
A
T
P
L
--
L
L
Q
--
M
L
P
A
P
F
----------
Q
D
W
T
T
-
P
L
L
S
D
R
-------------
Y
D
SHLLPG
G
Q
-----------
K
R
G
L
-
L
I
G
M
G
M
T
E
K
Q
G
G
S
D
V
-
M
S
-
N
T
T
R
A
E
R
-
L
--
E
D
G
S
Y
R
L
V
G
H
K
W
F
F
S
V
P
Q
-
S
D
A
H
L
V
L
A
Q
----
T
A
G
--------------
G
L
S
C
F
F
V
P
R
F
L
P
D
G
Q
R
N
A
I
R
L
E
R
L
K
D
K
L
G
N
R
S
N
A
S
C
E
V
E
F
Q
D
A
I
G
W
L
L
G
L
E
---------
G
E
G
I
R
L
I
L
K
M
G
G
M
T
R
F
D
C
A
L
G
S
H
A
M
M
R
R
A
F
S
L
A
I
Y
H
A
H
Q
R
H
V
F
G
N
P
L
I
Q
Q
P
L
M
R
H
V
L
S
R
M
A
L
Q
L
E
G
Q
T
A
L
L
F
R
---
L
---
A
R
---
A
W
D
R
R
--
A
D
A
----
K
------
E
A
L
W
A
R
L
F
T
P
A
A
K
F
V
I
C
K
R
G
M
P
F
V
A
E
A
M
E
V
L
G
G
I
G
Y
C
E
E
S
E
L
P
R
L
Y
R
E
M
P
V
N
S
I
W
E
G
S
G
N
I
M
C
L
D
V
L
R
--------------
V
L
N
-
K
----
Q
-
A
-
G
V
Y
D
L
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
73.88
33%
-62
- C3 -
3U33
10
AIDB_ECOLI
K:
[65-450]
------------------------------------------------------------------------------------------------
N
P
P
E
L
L
R
Y
D
A
Q
G
R
R
L
D
D
V
-
R
F
H
P
A
W
H
L
L
M
Q
A
L
C
T
N
-
R
VH
N
L
A
W
E
E
D
A
R
-
S
---
G
------
A
-
F
V
-----
A
R
--
A
A
R
F
M
L
H
A
Q
V
E
A
G
S
-
L
C
P
I
-
T
M
T
---
F
A
A
T
P
L
--
L
L
Q
--
M
L
P
A
P
F
----------
Q
D
W
T
T
-
P
L
L
S
D
R
-------------
Y
D
SHLLPG
G
Q
-----------
K
R
G
L
-
L
IGMGM
T
E
K
Q
G
G
S
D
V
-
M
S
-
N
T
T
R
A
E
R
-
L
--
E
D
G
S
Y
R
L
V
G
H
K
W
F
F
S
V
P
Q
-
S
D
A
H
L
V
L
A
Q
----
T
A
G
--------------
G
L
S
C
F
F
V
P
R
F
L
P
D
G
Q
R
N
A
I
R
L
E
R
L
K
D
K
L
G
N
R
S
N
A
S
C
E
V
E
F
Q
D
A
I
G
W
L
L
G
L
E
---------
G
E
G
I
R
L
I
L
K
M
G
G
M
T
R
F
D
C
A
L
G
S
H
A
M
M
R
R
A
F
S
L
A
I
Y
H
A
H
Q
R
H
V
F
G
N
P
L
I
Q
Q
P
L
M
R
H
V
L
S
R
M
A
L
Q
L
E
G
Q
T
A
L
L
F
R
---
L
---
A
R
---
A
W
D
R
R
--
A
DA----
K
------
E
A
L
W
A
R
L
F
T
P
A
A
K
F
V
I
C
K
R
G
M
P
F
V
A
E
A
M
E
V
L
G
G
I
G
Y
C
E
E
S
E
L
P
R
L
Y
R
E
M
P
V
N
S
I
W
E
G
S
G
N
I
M
C
L
D
V
L
R
--------------
V
L
N
-
K
----
Q
-
A
-
G
V
Y
D
L
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
73.57
33%
-63
- C3 -
3U33
3
AIDB_ECOLI
E:
[65-450]
------------------------------------------------------------------------------------------------
N
P
P
E
L
L
R
Y
D
A
Q
G
R
R
L
D
D
V
-
R
F
H
P
A
W
H
L
L
M
Q
A
L
C
T
N
-
R
VH
N
L
A
W
E
E
D
A
R
-
S
---
G
------
A
-
F
V
-----
A
R
--
A
A
R
F
M
L
H
A
Q
V
E
A
G
S
-
L
C
P
I
-
T
M
T
---
F
A
A
T
P
L
--
L
L
Q
--
M
L
P
A
P
F
----------
Q
D
W
T
T
-
P
L
L
S
D
R
-------------
Y
D
SHLLPG
G
Q
-----------
K
R
G
L
-
L
IGMGM
T
E
K
Q
G
G
S
D
V
-
M
S
-
N
T
T
R
A
E
R
-
L
--
E
D
G
S
Y
R
L
V
G
H
K
W
F
F
S
V
P
Q
-
S
D
A
H
L
V
L
A
Q
----
T
A
G
--------------
G
L
S
C
F
F
V
P
R
F
L
P
D
G
Q
R
N
A
I
R
L
E
R
L
K
D
K
L
G
N
R
S
N
A
S
C
E
V
E
F
Q
D
A
I
G
W
L
L
G
L
E
---------
G
E
G
I
R
L
I
L
K
M
G
G
M
T
R
F
D
C
A
L
G
S
H
A
M
M
R
R
A
F
S
L
A
I
Y
H
A
H
Q
R
H
V
F
G
N
P
L
I
Q
Q
P
L
M
R
H
V
L
S
R
M
A
L
Q
L
E
G
Q
T
A
L
L
F
R
---
L
---
A
R
---
A
W
D
R
R
--
A
DA----
K
------
E
A
L
W
A
R
L
F
T
P
A
A
K
F
V
I
C
K
R
G
M
P
F
V
A
E
A
M
E
V
L
G
G
I
G
Y
C
E
E
S
E
L
P
R
L
Y
R
E
M
P
V
N
S
I
W
E
G
S
G
N
I
M
C
L
D
V
L
R
--------------
V
L
N
-
K
----
Q
-
A
-
G
V
Y
D
L
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
73.52
31%
-48
- C3 -
5EZ3
5
?
A:
[33-467]
------------------------KT
H
E
V
T
N
Q
T
P
P
I
T
G
-----
T
N
A
Y
L
G
D
P
L
L
M
Q
I
A
A
R
F
--
P
K
E
L
---
H
T
E
L
E
Q
A
G
R
F
V
L
S
-
A
-
E
A
Q
D
L
A
R
L
A
N
T
E
L
P
K
L
R
T
H
D
R
Q
G
R
R
I
D
L
V
E
Y
H
P
A
Y
H
A
L
M
R
R
S
V
A
Q
G
L
H
--
S
S
I
W
E
D
N
P
L
-
E
---
S
G
R
R
---
H
-
Q
A
-----
R
A
--
A
R
F
Y
L
T
A
-
Q
L
E
A
G
H
-
L
C
P
L
T
M
T
S
---
A
---
S
L
--
A
A
L
--
M
A
S
P
E
V
Y
K
Q
W
SPAVLS
R
K
Y
D
F
S
Q
K
P
A
F
R
-------------
K
Q
------
G
V
-----------
T
L
G
M
G
M
-----
T
E
K
Q
G
G
T
D
V
-
R
A
-
N
A
T
R
A
E
P
-
A
I
-
G
G
-
A
W
R
L
T
G
H
K
W
F
M
S
A
P
M
-
S
D
A
F
L
T
L
A
Q
------------------
T
K
E
G
L
S
C
F
L
L
P
R
L
G
E
K
G
E
S
N
G
F
F
F
Q
R
L
K
D
K
L
G
N
R
S
N
A
S
S
E
V
E
F
-
D
G
A
L
G
Q
M
I
G
S
P
--------
G
E
G
V
K
T
I
M
D
M
V
T
L
T
R
L
D
C
A
V
A
S
A
G
L
M
R
S
G
L
A
E
A
V
H
H
S
R
H
R
H
V
F
G
K
P
L
V
E
Q
P
L
M
Q
R
V
L
A
D
M
A
L
D
V
A
G
A
T
A
L
S
M
R
L
A
R
A
---
F
D
---
M
A
A
S
D
--
R
------
A
------
E
A
A
F
A
R
S
M
T
P
V
V
K
Y
W
V
C
K
I
A
P
A
L
L
Y
E
A
M
E
C
L
G
G
N
G
Y
I
E
D
G
N
L
A
R
A
Y
R
E
A
P
V
N
A
I
W
E
G
S
G
N
V
M
A
L
D
V
A
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
73.48
33%
-62
- C3 -
3U33
4
AIDB_ECOLI
A:
[65-450]
------------------------------------------------------------------------------------------------
N
P
P
E
L
L
R
Y
D
A
Q
G
R
R
L
D
D
V
-
R
F
H
P
A
W
H
L
L
M
Q
A
L
C
T
N
-
R
VH
N
L
A
W
E
E
D
A
R
-
S
---
G
------
A
-
F
V
-----
A
R
--
A
A
R
F
M
L
H
A
Q
V
E
A
G
S
-
L
C
P
I
-
T
M
T
---
F
A
A
T
P
L
--
L
L
Q
--
M
L
P
A
P
F
----------
Q
D
W
T
T
-
P
L
L
S
D
R
-------------
Y
D
SHLLPG
G
Q
-----------
K
R
G
L
-
L
I
G
M
G
M
T
E
K
Q
G
G
S
D
V
-
M
S
-
N
T
T
R
A
E
R
-
L
--
E
D
G
S
Y
R
L
V
G
H
K
W
F
F
S
V
P
Q
-
S
D
A
H
L
V
L
A
Q
----
T
A
G
--------------
G
L
S
C
F
F
V
P
R
F
L
P
D
G
Q
R
N
A
I
R
L
E
R
L
K
D
K
L
G
N
R
S
N
A
S
C
E
V
E
F
Q
D
A
I
G
W
L
L
G
L
E
---------
G
E
G
I
R
L
I
L
K
M
G
G
M
T
R
F
D
C
A
L
G
S
H
A
M
M
R
R
A
F
S
L
A
I
Y
H
A
H
Q
R
H
V
F
G
N
P
L
I
Q
Q
P
L
M
R
H
V
L
S
R
M
A
L
Q
L
E
G
Q
T
A
L
L
F
R
---
L
---
A
R
---
A
W
D
R
R
--
A
D
A
----
K
------
E
A
L
W
A
R
L
F
T
P
A
A
K
F
V
I
C
K
R
G
M
P
F
V
A
E
A
M
E
V
L
G
G
I
G
Y
C
E
E
S
E
L
P
R
L
Y
R
E
M
P
V
N
S
I
W
E
G
S
G
N
I
M
C
L
D
V
L
R
--------------
V
L
N
-
K
----
Q
-
A
-
G
V
Y
D
L
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
73.44
33%
-61
- C3 -
3U33
4
AIDB_ECOLI
F:
[65-450]
------------------------------------------------------------------------------------------------
N
P
P
E
L
L
R
Y
D
A
Q
G
R
R
L
D
D
V
-
R
F
H
P
A
W
H
L
L
M
Q
A
L
C
T
N
-
R
VH
N
L
A
W
E
E
D
A
R
-
S
---
G
------
A
-
F
V
-----
A
R
--
A
A
R
F
M
L
H
A
Q
V
E
A
G
S
-
L
C
P
I
-
T
M
T
---
F
A
A
T
P
L
--
L
L
Q
--
M
L
P
A
P
F
----------
Q
D
W
T
T
-
P
L
L
S
D
R
-------------
Y
D
SHLLPG
G
Q
-----------
K
R
G
L
-
L
IGMGM
T
E
K
Q
G
G
S
D
V
-
M
S
-
N
T
T
R
A
E
R
-
L
--
E
D
G
S
Y
R
L
V
G
H
K
W
F
F
S
V
P
Q
-
S
D
A
H
L
V
L
A
Q
----
T
A
G
--------------
G
L
S
C
F
F
V
P
R
F
L
P
D
G
Q
R
N
A
I
R
L
E
R
L
K
D
K
L
G
N
R
S
N
A
S
C
E
V
E
F
Q
D
A
I
G
W
L
L
G
L
E
---------
G
E
G
I
R
L
I
L
K
M
G
G
M
T
R
F
D
C
A
L
G
S
H
A
M
M
R
R
A
F
S
L
A
I
Y
H
A
H
Q
R
H
V
F
G
N
P
L
I
Q
Q
P
L
M
R
H
V
L
S
R
M
A
L
Q
L
E
G
Q
T
A
L
L
F
R
---
L
---
A
R
---
A
W
D
R
R
--
A
DA----
K
------
E
A
L
W
A
R
L
F
T
P
A
A
K
F
V
I
C
K
R
G
M
P
F
V
A
E
A
M
E
V
L
G
G
I
G
Y
C
E
E
S
E
L
P
R
L
Y
R
E
M
P
V
N
S
I
W
E
G
S
G
N
I
M
C
L
D
V
L
R
--------------
V
L
N
-
K
----
Q
-
A
-
G
V
Y
D
L
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
73.42
31%
-51
- C3 -
5EZ3
6
?
D:
[33-467]
------------------------KTHEV
T
N
Q
T
P
P
I
T
G
-----
T
N
A
Y
L
G
D
P
L
L
M
Q
I
A
A
R
F
--
P
K
E
L
---
H
T
E
L
E
Q
A
G
R
F
V
L
S
-
A
-
E
A
Q
D
L
A
R
L
A
N
T
E
L
P
K
L
R
T
H
D
R
Q
G
R
R
I
D
L
V
E
Y
H
P
A
Y
H
A
L
M
R
R
S
V
A
Q
G
L
H
--
S
S
I
W
E
D
N
P
L
-
E
---
S
G
R
R
---
H
-
Q
A
-----
R
A
--
A
R
F
Y
L
T
A
-
Q
L
E
A
G
H
-
L
C
P
L
T
M
T
S
---
A
---
S
L
--
A
A
L
--
M
A
S
P
E
V
YKQWSPAVLS
R
K
Y
D
F
S
Q
K
P
A
F
R
-------------
K
Q
------
G
V
-----------
T
L
G
M
G
M
-----
T
E
K
Q
G
G
T
D
V
-
R
A
-
N
A
T
R
A
E
P
-
A
I-
G
G
-
A
W
R
L
T
G
H
K
W
F
M
S
A
P
M
-
S
D
A
F
L
T
L
A
Q
------------------
T
K
E
G
L
S
C
F
L
L
P
R
L
G
E
K
G
E
S
N
G
F
F
F
Q
R
L
K
D
K
L
G
N
R
S
N
A
S
S
E
V
E
F
-
D
G
A
L
G
Q
M
I
G
S
P
--------
G
E
G
V
K
T
I
M
D
M
V
T
L
T
R
L
D
C
A
V
A
S
A
G
L
M
R
S
G
L
A
E
A
V
H
H
S
R
H
R
H
V
F
G
K
P
L
V
E
Q
P
L
M
Q
R
V
L
A
D
M
A
L
D
V
A
G
A
T
A
L
S
M
R
LAR
A
---
F
D
---
M
A
A
S
D
--
R
------
A
------
E
A
A
F
A
R
S
M
T
P
V
V
K
Y
W
V
C
K
I
A
P
A
L
L
Y
E
A
M
E
C
L
G
G
N
G
Y
I
E
D
G
N
L
A
R
A
Y
R
E
A
P
V
N
A
I
W
E
G
S
G
N
V
M
A
L
D
V
A
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
73.40
33%
-62
- C3 -
3U33
2
AIDB_ECOLI
H:
[65-450]
------------------------------------------------------------------------------------------------
N
P
P
E
L
L
R
Y
D
A
Q
G
R
R
L
D
D
V
-
R
F
H
P
A
W
H
L
L
M
Q
A
L
C
T
N
-
R
VH
N
L
A
W
E
E
D
A
R
-
S
---
G
------
A
-
F
V
-----
A
R
--
A
A
R
F
M
L
H
A
Q
V
E
A
G
S
-
L
C
P
I
-
T
M
T
---
F
A
A
T
P
L
--
L
L
Q
--
M
L
P
A
P
F
----------
Q
D
W
T
T
-
P
L
L
S
D
R
-------------
Y
D
SHLLPG
G
Q
-----------
K
R
G
L
-
L
IGMGM
T
E
K
Q
G
G
S
D
V
-
M
S
-
N
T
T
R
A
E
R
-
L
--
E
D
G
S
Y
R
L
V
G
H
K
W
F
F
S
V
P
Q
-
S
D
A
H
L
V
L
A
Q
----
T
A
G
--------------
G
L
S
C
F
F
V
P
R
F
L
P
D
G
Q
R
N
A
I
R
L
E
R
L
K
D
K
L
G
N
R
S
N
A
S
C
E
V
E
F
Q
D
A
I
G
W
L
L
G
L
E
---------
G
E
G
I
R
L
I
L
K
M
G
G
M
T
R
F
D
C
A
L
G
S
H
A
M
M
R
R
A
F
S
L
A
I
Y
H
A
H
Q
R
H
V
F
G
N
P
L
I
Q
Q
P
L
M
R
H
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---
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---
A
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--
A
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------
E
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--------------
V
L
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----
Q
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--------------------------------------------------------------------------------------------------------------------------------------------------------------