@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0186: (2015-12-25 )
MKALTSSLLGLFAAPVLAGLLGAYVPLASAAPPKEIRIAVPDVSAGSSHSGGGVVDVLYTRQLLEKEFANDGIAVKWSFFKGAGPVVNEAFANGQVDFAYLGDLAAIIGKSGGLDSRLLAATARGVNHYLGVQPGSGIKTLEDLKGKRVGIFRGTASQLSFDNALASVGLSEKDLKVINLDFSAALSALAARQIDATWGLAGLFALRDRGLAEIPLSTRDLNGAGTLQALLVGSGAFVDAHPDITERLLKVQLQAQDWLAREENRDAYIELVSKQASYPVVILQSEYRGRKLGDALSPRLDADFLGRLDASIQAAKRFGLIRREFSAEQWAAPELLEAAGKLAKAKAVAQAAE
Atome Classification :
(20 SA)
.........10........20........30........40........50........----60-.....---...70--..-.-...--..80-.--...----...----.90........100-..-...-----..-110---..----------------.--.-.....120.-.-..-.-..130...--------------..-.-.140..-..-....150-------------------------.-.-.-------...-------------------..-160.......170-----------.-...-------....180------------------------.-..--------------------------......--190-....-...200..-.--..-....210.......220-----......------.---.------------230.......240.......250.--......260..-.....270.--..--.--.---..--280......-.--290..--.------.------.-------...---300.-------------......310..-....--.-320..-------..-.----..330.----......340.......350.----------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MK
A
L
T
S
S
L
L
G
L
F
A
A
P
V
L
A
G
L
L
G
A
YVPLASAAPP
K
E
I
R
I
AVPDVSAGSSHSGG
G
V
V
D
V
L
Y
----
T
R
-
Q
L
L
E
K
---
E
FAND--
G
I
-
A
-
V
K
W
--
S
FFK-G--AG
P
----
V
V
N
----
E
A
FANG
Q
V
D
F
A
Y
L
G
-
D
L
-
A
A
I
-----IG-K-----SG----------------G--L-
D
S
R
L
L
A
A
T
A-R-GV-
N
-
H
YLGVQPG--------------SG-I-K
T
-
L
E
D
-LK-GK
R
V
G
I
--------------------------
F
-R-G-------T
A
S
-------------------QL-
S
F
D
N
A
L
A
SVGL-S-----------E-K
D
L
-------
K
V
I
N
L--------------------------
D
-
F
S
--------------------------
A
A
L
S
A
L
--
A
A
R
-
Q
I
D
A
-
T
W
G
L
--
A
G
-
L
--
F
A
-
L
R
DRGLAEIPLSTRDL------NGA
G
T
L
------
Q
---
A
------------
L
L
VGS
G
A
F
VDAH
P
D
I
T
E
R
L
L
K
V
Q
L
--
Q
A
Q
D
W
LAREEN-
R
D
A
Y
I
E
L
V
S
--KQ--A--S---Y
P
--
V
V
I
L
QSEYR-G--R-KLG--D------A------L-------SPR---L
D
A
D
-------------
F
L
G
R
L
D
A
S
I
Q
A
-
A
K
R
F
--
G
-
L
I
R
R
E-------F
S
-
A
----
E
QWA
A
P
----
E
L
L
E
A
A
G
K
L
A
K
A
K
A
V
AQAAE----------------------------
44
Fugue
94.05
29%
-73
- C3 -
3UIF
3
?
A:
[2-331]
-----------------------------
V
E
D
L
K
V
V
R
I
A
S
V
A
T
N
V
G
G
K
T
V
Y
A
G
-
S
A
S
L
V
----
V
N
-
G
A
F
P
E
---
E
L
R
K
Q
--
G
I
-
K
-
V
E
W
--
V
P
A
A
M
A
S-
V
G
P
----
V
I
N
----
E
G
F
A
S
G
K
I
D
F
G
I
Y
G
-
D
L
-
P
P
I
-----
I
L
-
N
-----
A
S
----------------
K
--
P
-
T
V
Q
L
V
A
P
W
G
-
T
-
T
S
-
N
-
S
Y
L
V
V
P
K
N
--------------
S
T
-
A
-
K
S
-
I
K
D
-
L
K
-
G
K
K
I
A
L
--------------------------
H
-
R
-
G
-------
R
P
W
-------------------
E
L
-
A
F
S
N
L
L
Q
S
E
G
L
-
T
-----------
F
-
K
D
F
-------
K
I
V
N
V
--------------------------
N
-
P
Q
--------------------------
V
G
A
A
A
L
--
A
S
G
-
T
V
D
G
-
F
F
S
L
--
F
D
-
S
--
Y
I
-
L
E
D
R
G
V
G
K
I
I
W
S
T
K
T
-------
A
P
V
D
W
K
------
L
M
--
G
------------
G
V
W
A
R
N
D
F
V
K
Q
N
P
E
I
T
Q
A
I
V
T
A
Y
L
--
K
S
V
H
W
V
A
Q
D
E
N
-
K
E
T
Y
I
R
E
-
Y
--
S
N
--
K
--
I
---
Y
P
--
E
S
V
N
R
R
E
Y
D
-
Q
--
D
-
N
V
S
W
R
Q
------
R
------
W
-------
S
P
L
---
Y
D
V
A
-------------
L
Q
E
H
Y
R
K
A
V
A
Y
-
A
Q
A
S
--
G
-
L
T
R
T
Q
-------
A
D
-
V
----
Q
Q
M
L
N
P
----
H
F
V
A
T
A
L
K
E
L
K
L
E
G
F
W
T
P
N
A
ENLY------------------------
27
HHSearch
91.95
29%
-81
- C3 -
3UIF
3
?
A:
[4-321]
-------------------------------
D
L
K
V
V
R
I
A
S
V
A
T
N
---
V
G
G
--
K
T
V
Y
A
G
S
A
S
L
V
V
N
-
G
A
F
P
E
---
E
L
R
K
Q
--
G
I
-
K
-
V
E
W
--
V
P
A
A
-
M
AS
V
G
P
----
V
I
N
----
E
G
F
A
S
G
K
I
D
F
G
I
Y
G
-
D
L
-
P
P
I
-----
I
L
-
N
-----
A
S
----------------
K
--
P
-
T
V
Q
L
V
A
P
W
G
-
T
-
T
S
-
N
-
S
Y
L
V
V
P
K
N
--------------
S
T
-
A
-
K
S
-
I
K
D
-
L
K
-
G
K
K
I
A
L
--------------------------
H
-
R
-
G
-------
R
P
W
-------------------
E
L
-
A
F
S
N
L
L
Q
S
E
G
L
-
T
-----------
F
-
K
D
F
-------
K
I
V
N
V
--------------------------
N
-
P
Q
--------------------------
V
G
A
A
A
L
--
A
S
G
-
T
V
D
G
-
F
F
S
L
--
F
D
-
S
--
Y
I
-
L
E
D
R
G
V
G
K
I
I
W
S
T
K
T
A
------
P
V
D
W
K
L
------
M
---
G
------------
G
V
W
A
R
N
D
F
V
K
Q
N
P
E
I
T
Q
A
I
V
T
A
Y
L
--
K
S
V
H
W
V
A
--
Q
D
-
E
N
K
E
T
Y
I
-
R
--
E
Y
--
S
NK
I
---
Y
P
--
E
S
V
N
R
R
E
Y
D
-
Q
DN
V
-
S
W
R
--
Q
------
R
------
W
-------
S
P
L
---
Y
D
V
A
-------------
L
Q
E
H
Y
R
K
A
V
A
Y
-
A
Q
A
S
--
G
-
L
T
R
T
Q
-------
A
D
-
V
----
Q
Q
M
L
N
P
----
H
F
V
A
T
A
L
K
E
L
K
L
E
G
F
W
T
P
N
A
----------------------------
1
PsiBlast_PDB
88.73
30%
-81
- C3 -
3UIF
3
?
A:
[35-318]
--------------------------------------------------------------------
F
P
E
---
E
L
R
K
Q
--
G
I
-
K
-
V
E
W
VP
A
A
M
A
-
S
--
V
G
P
----
V
I
N
----
E
G
F
A
S
G
K
I
D
F
G
I
Y
G
-
D
L
-
P
P
I
-----
I
L
-
N
-----
A
S
----------------
K
--
P
-
T
V
Q
L
V
A
P
W
G
-
T
-
T
S
-
N
-
S
Y
L
V
V
P
K
N
--------------
S
T
-
A
-
K
S
-
I
K
D
-
L
K
-
G
K
K
I
A
L
--------------------------
H
-
R
-
G
-------
R
P
W
-------------------
E
L
-
A
F
S
N
L
L
Q
S
E
G
L
-
T
-----------
F
-
K
D
F
-------
K
I
V
N
V
--------------------------
N
-
P
Q
--------------------------
V
G
A
A
A
L
--
A
S
G
-
T
V
D
G
-
F
F
S
L
--
F
D
-
S
--
Y
I
-
L
E
D
R
G
V
G
K
I
I
W
S
T
K
T
A
------
P
V
D
W
K
L
------
M
---
G
------------
G
V
W
A
R
N
D
F
V
K
Q
N
P
E
I
T
Q
A
I
V
T
A
Y
L
--
K
S
V
H
W
V
A
Q
D
E
N
-
K
E
T
Y
I
R
E
Y
S
--
N
K
--
I
------
Y
P
--
E
S
V
N
R
R
E
Y
D
-
Q
--
D
-
N
V
S
W
R
Q
------
R
------
W
-------
S
P
L
---
Y
D
V
A
-------------
L
Q
E
H
Y
R
K
A
V
A
Y
-
A
Q
A
S
--
G
-
L
T
R
T
Q
-------
A
D
-
V
----
Q
Q
M
L
N
P
----
H
F
V
A
T
A
L
K
E
L
K
L
E
G
F
W
T
P
N
A
----------------------------
45
Fugue
83.33
24%
-85
- C3 -
3E4R
1
?
A:
[25-315]
-----------------------------
A
A
E
P
A
Q
L
R
I
G
Y
--------
Q
K
A
V
S
S
L
V
L
A
K
----
Q
H
-
R
L
L
E
Q
---
R
F
--
P
--
R
T
-
K
-
I
T
W
--
V
E
F
P
----
A
G
P
----
Q
L
L
----
E
A
L
N
V
G
S
I
D
L
G
G
A
G
-
D
I
-
P
P
L
-----
F
A
-
Q
-----
A
A
----------------
G
--
A
-
D
L
L
Y
V
G
W
V
P
-
P
-
T
P
-
K
A
E
T
I
L
V
P
S
K
--------------
S
A
-
L
-
R
T
-
V
A
D
-
L
K
-
G
K
R
I
A
F
--------------------------
Q
-
K
-
G
-------
S
S
A
-------------------
H
N
-
L
L
L
R
V
L
A
K
S
G
L
-
S
-----------
M
-
R
D
I
-------
T
P
L
Y
L
--------------------------
S
-
P
A
--------------------------
N
A
R
A
A
F
--
A
A
G
-
Q
V
D
--
A
W
A
I
WD
P
W
-
Y
--
S
A
-
L
T
L
D
G
S
A
R
L
L
A
N
G
E
G
L
------
G
L
T
G
------------
G
------------
F
F
L
S
S
R
R
Y
A
T
A
W
G
P
F
V
Q
Q
V
M
G
T
L
N
--
Q
A
D
G
L
L
E
R
--
D
-
R
A
G
S
I
K
T
L
A
--
Q
V
--
S
--
G
---
L
P
--
P
A
V
V
E
R
T
L
A
-
H
--
R
-
P
----
P
------
A
------
S
-------
V
Q
P
---
L
S
A
Q
-------------
V
I
K
A
Q
Q
A
T
A
D
L
-
F
Y
A
Q
--
R
-
L
L
P
K
R
-------
V
L
-
V
-------------------------
A
P
A
V
W
R
A
P
D
----------------------------
25
HHSearch
80.89
22%
-82
- C3 -
3KSX
4
?
A:
[25-313]
-----------------------------
A
A
E
P
A
Q
L
R
I
G
Y
Q
K
A
V
--------
S
S
L
V
L
A
K
----
Q
H
-
R
L
L
E
Q
---
R
F
--
P
--
R
T
-
K
-
I
T
W
--
V
E
F
P
----
A
G
P
----
Q
L
L
----
E
A
L
N
V
G
S
I
D
L
G
G
A
G
-
D
I
-
P
P
L
-----
F
A
-
Q
-----
A
A
----------------
G
--
A
-
D
L
L
Y
V
G
W
V
P
-
P
T
P
K
-
A
-
E
T
I
L
V
P
S
K
--------------
S
A
-
L
-
R
T
-
V
A
D
-
L
K
-
G
K
R
I
A
F
--------------------------
Q
-
K
-
G
-------
S
S
A
-------------------
H
N
-
L
L
L
R
V
L
A
K
S
G
L
-
S
-----------
M
-
R
D
I
-------
T
P
L
Y
L
--------------------------
S
-
P
A
--------------------------
N
A
R
A
A
F
--
A
A
G
-
Q
V
D
A
-
W
A
I
W
--
D
P
W
Y
--
S
A
-
L
T
L
D
G
S
A
R
L
L
A
N
G
E
G
---------
L
G
L
T
------
G
---
G
------------
F
F
L
S
S
R
R
Y
A
T
A
W
G
P
F
V
Q
Q
V
M
G
T
L
N
--
Q
A
D
G
L
L
E
--
R
D
-
R
A
G
S
I
K
T
L
A
--
Q
V
--
S
--
G
---
L
P
--
P
A
V
V
E
R
T
L
A
-
H
--
R
-
P
P
A
---------
S
--------------
V
Q
P
---
L
S
A
Q
-------------
V
I
K
A
Q
Q
A
T
A
D
L
-
F
Y
A
Q
--
R
-
L
L
P
K
R
-------
V
L
-
V
----
A
P
A
V
W
R
----
A
-----------------------------------------------
29
HHSearch
75.30
21%
-80
- C3 -
2X26
1
SSUA_ECOLI
A:
[2-295]
--------------------------------
P
E
A
L
R
I
G
Y
Q
K
G
S
--------
I
G
M
V
L
A
K
----
S
H
-
Q
L
L
E
-------
K
R
Y
P
E
S
-
K
-
I
S
W
--
V
E
F
P
----
A
G
P
----
Q
M
L
----
E
A
L
N
V
G
S
I
D
L
G
S
T
G
-
D
I
-
P
P
I
-----
F
A
-
Q
-----
A
A
----------------
G
--
A
-
D
L
V
Y
V
G
V
E
P
P
K
-
P
K
-
A
-
E
V
I
L
V
A
E
N
--------------
S
P
-
I
-
K
T
-
V
A
D
-
L
K
-
G
H
K
V
A
F
--------------------------
Q
-
K
-
G
-------
S
S
S
-------------------
H
N
-
L
L
L
R
A
L
R
Q
A
G
L
-
K
-----------
F
-
T
D
I
-------
Q
P
T
Y
L
--------------------------
T
-
P
A
--------------------------
D
A
R
A
A
F
--
Q
Q
G
-
N
V
D
A
-
W
A
I
W
--
D
P
Y
Y
--
S
A
-
A
L
L
Q
G
G
V
R
V
L
K
D
G
T
D
---------
L
N
Q
T
------
G
---
S
------------
F
Y
L
A
A
R
P
Y
A
E
K
N
G
A
F
I
Q
G
V
L
A
T
F
S
--
E
A
D
A
L
T
R
--
S
Q
-
R
E
Q
S
I
A
L
L
A
--
K
T
--
M
--
G
---
L
P
--
A
P
V
I
A
S
Y
L
D
-
H
--
R
-
P
P
T
---------
T
--------------
I
K
P
---
V
N
A
E
-------------
V
A
A
L
Q
Q
Q
T
A
D
L
-
F
Y
E
N
--
R
-
L
V
P
K
K
-------
V
D
-
I
----
R
Q
R
I
W
Q
----
P
T
Q
L
E
G
K
Q
L
E
F
R
V
P
G
N
E
N
L
Y
----------------------------
24
HHSearch
72.25
21%
-66
- C3 -
3QSL
1
?
A:
[29-344]
-----------------------------
K
L
E
K
A
K
V
Q
I
A
V
G
G
K
P
L
I
--
Y
Y
--
L
P
L
T
I
A
E
----
V
K
-
G
F
F
K
-------
D
E
--
G
L
-
D
-
V
S
I
--
A
D
F
A
----
G
G
S
----
K
A
L
----
Q
A
V
V
G
G
S
A
D
V
V
S
G
A
-
F
E
-
H
T
L
-----
S
L
-
Q
-----
A
K
----------------
G
--
Q
-
F
Y
R
A
F
A
L
Q
G
-
R
-
A
P
-
M
-
I
G
V
G
V
S
K
K
NL------------
P
G
-
Y
-
K
G
-
P
A
D
-
L
K
-
G
R
K
I
G
V
--------------------------
T
A
P
-
G
-------
S
S
T
-------------------
N
M
-
V
V
N
F
F
L
A
K
H
G
L
-
K
-----------
A
-
S
D
V
-------
S
F
I
G
V
--------------------------
G
A
G
A
--------------------------
G
A
V
T
A
L
--
R
S
G
-
Q
I
D
A
-
I
S
N
T
--
D
P
V
V
--
S
M
-
L
E
T
S
G
D
I
Q
I
I
V
D
T
R
T
L
K
D
T
K
E
I
F
G
G
N
M
P
------
A
---
G
------------
C
L
Y
A
P
Q
A
F
V
D
A
N
P
N
T
A
Q
A
L
T
N
A
I
V
--
R
A
D
K
W
I
Q
--
K
A
G
A
D
E
I
A
K
A
V
P
--
E
G
--
Y
--
L
L--
G
D
--
P
A
V
Y
K
A
A
I
G
-
K
--
S
-
M
----
E
------
G
------
L
-------
S
-
P
---
D
G
V
I
-------------
P
E
D
G
A
A
T
A
L
K
A
-
L
A
A
F
VP
D
-
F
D
A
A
K
-------
V
D
-
P
----
A
K
A
W
T
N
----
E
Y
T
R
R
A
N
E
K
Y
P
N
------------------------------------
47
Fugue
72.16
20%
-83
- C3 -
2DE3
2
SOXB_RHOSG
A:
[20-363]
------
D
T
L
T
Y
S
N
S
P
V
P
N
A
L
L
T
A
S
E
S
--------------------------------------------
G
---
F
L
D
A
A
--
G
I
-
E
-
L
D
V
--
L
S
G
Q
-
Q
--
G
T
V
----
H
F
T
-----
Y
D
Q
P
A
Y
T
R
F
G
--
G
-
E
I
-
P
P
L
-----
L
S
-
E
-----
G
L
----------------
R
AP
G
-
R
T
R
L
L
G
I
T
P
-
L
-
L
G
-
R
-
Q
G
F
F
V
R
D
D
--------------
S
P
-
I
-
T
A
-
A
A
D
-
L
A
-
G
R
R
I
G
V
S
A
S
A
I
R
I
L
R
GQLGDYLELD
P
W
R
Q
T
L
V
A
-
L
-
G
-------
S
W
E
-------------------
A
R
-
A
L
L
H
T
L
E
H
G
E
L
-
G
-----------
V
-
D
D
V
-------
E
L
V
P
I
S
S
P
GVDVP
A
E
Q
L
E
E
SATVK
G
A
D
L
F
PD
V
-
A
R
--------------------------
G
Q
A
A
V
L
--
A
S
G
-
D
V
D
A
-
L
Y
S
W
--
L
P
-
W
--
A
G
-
E
L
Q
A
T
G
A
R
P
V
V
D
L
G
L
D
------
E
R
N
A
Y
A
------
S
---
V
------------
W
T
V
S
-
S
G
L
V
R
Q
R
P
G
L
V
Q
R
L
V
D
A
A
V
--
D
A
G
L
W
A
--
R
D
H
-
S
D
A
V
T
S
L
H
A
--
A
N
--
L
--
G
---
V
S
--
T
G
A
V
G
Q
G
F
--
G
--
A
-
D
F
Q
--
Q
------
R
------
L
-------
V
P
R
---
L
D
H
D
-------------
A
L
A
L
L
E
R
T
Q
Q
F
-
L
L
T
N
--
N
-
L
L
Q
E
P
-------
V
A
-
L
----
D
Q
W
A
A
P
----
E
F
L
N
N
S
L
N
R
---------------------------------------
46
Fugue
70.04
19%
-64
- C3 -
3QSL
1
?
A:
[28-345]
----------------------------
Q
K
L
E
K
A
K
V
Q
I
A
V
-----------
G
G
K
P
L
I
Y
Y
----
L
P
-
L
T
I
A
E
V
K
G
F
F
K
D
E
--
G
L
-
D
-
V
S
I
--
A
D
F
A
-
G
---
G
S
----
K
A
L
----
Q
A
V
V
G
G
S
A
D
V
V
S
G
A
-
F
E
-
H
T
L
-----
S
L
-
Q
-----
A
K
----------------
G
--
Q
-
F
Y
R
A
F
A
L
Q
G
-
R
-
A
P
M
I
-
G
V
G
V
S
K
K
N
--------------
L
P
G
Y
-
K
G
-
P
A
D
-
L
K
-
G
R
K
I
G
V
--------------------------
T
-
A
-
P
-------
G
S
S
-------------------
T
N
M
V
V
N
F
F
L
A
K
H
G
L
-
K
-----------
A
-
S
D
V
-------
S
F
I
G
V
G-------------------------
A
-
G
A
--------------------------
G
A
V
T
A
L
--
R
S
G
-
Q
I
D
A
-
I
S
N
T
--
D
P
-
V
--
V
S
M
L
E
T
S
G
D
I
Q
I
I
V
D
T
R
T
L
------
K
D
T
K
E
I
FG
G
N
M
P
A
---
G
------------
C
L
Y
A
P
Q
A
F
V
D
A
N
P
N
T
A
Q
A
L
T
N
A
I
V
--
R
A
D
K
W
I
Q
K
A
G
A
-
D
E
I
A
K
A
V
P
E
--
G
Y
--
L
--
L
---
G
D
--
P
A
V
Y
K
A
A
I
G
-
K
--
S
M
E
G
---
L
------
S
------
P
-------
D
G
V
---
I
P
E
D
-------------
G
A
A
T
A
L
K
A
L
A
A
-
F
V
P
---
D
-
F
D
A
A
K
-------
V
D
-
P
----
A
K
A
W
T
N
----
E
Y
T
R
R
A
N
E
K
Y
P
N
------------------------------------
26
HHSearch
67.67
13%
-73
* C3 *
3UN6
5
?
A:
[51-340]
--------------------------------
Q
Q
V
I
K
I
G
Y
L
P
I
T
H
----
S
--
A
N
L
M
M
T
K
----
K
L
L
S
Q
Y
N
-------
H
P
--
K
Y
-
K
-
L
E
L
--
V
K
F
N
----
N
W
P
----
D
L
M
----
D
A
L
N
S
G
R
I
D
G
A
S
T
L
-
I
E
-
L
A
M
-----
K
S
-
K
-----
Q
K
----------------
G
--
S
-
N
I
K
A
V
A
L
G
H
---
H
E
-
G
-
N
V
I
M
G
Q
K
G
--------------
M
H
-
L
-
N
E
-
F
N
N
N
G
D
-
D
Y
H
F
G
I
--------------------------
P
-
H
-
R
-------
Y
S
T
H
------------------
Y
L
-
L
L
E
E
L
R
K
Q
L
K
I
-
K
-----------
P
-
G
H
F
-------
S
Y
H
E
M
--------------------------
S
-
P
A
--------------------------
E
M
P
A
A
L
--
S
E
H
-
R
I
T
G
-
Y
S
V
A
--
E
P
F
G
--
A
L
-
G
E
K
L
G
K
G
K
T
L
K
H
G
D
D
V
-------
I
P
D
A
Y
------
C
---
C
------------
V
L
V
L
R
G
E
L
L
D
Q
H
K
D
V
A
Q
A
F
V
Q
D
Y
K
--
K
S
G
F
K
M
N
---
D
-
R
K
Q
S
V
D
I
M
T
--
H
H
--
F
--
K
---
Q
S
--
R
D
V
L
T
Q
S
A
A
-
W
--
T
-
S
Y
G
------------------------
D
------
L
T
I
-------------
K
P
S
G
Y
Q
E
I
T
T
L
-
V
K
Q
H
--
H
-
L
F
-
N
P
-------
P
A
-
Y
----
D
D
F
V
E
P
----
S
L
Y
K
E
A
S
R
S
---------------------------------------
28
HHSearch
67.00
19%
-81
- C3 -
2DE3
2
SOXB_RHOSG
A:
[31-363]
----------------------------------------------------
N
A
L
L
T
A
S
----
E
S
-
G
F
L
D
-------
A
A
--
G
I
-
E
-
L
D
V
--
L
S
G
Q
----
Q
G
T
----
V
H
F
----
T
Y
D
Q
P
A
Y
T
R
F
G
G
E
I
-
P
P
-
L
L
S
-----
E
G
L
R
-----
A
P
----------------
G
R-
T
-
R
L
L
G
I
T
P
-
L
---
L
G
-
R
-
Q
G
F
F
V
R
D
D
--------------
S
P
-
I
-
T
A
-
A
A
D
-
L
A
-
G
R
R
I
G
V
--------------------------
S
-
A
-
S
A
I
R
I
L
R
G
Q
L
G
DYLELD
P
W
R
Q
T
L
V
A
L
G
S
W
E
A
R
-
A
L
L
H
T
L
E
H
G
E
L
-
G
-----------
V
-
D
D
V
-------
E
L
V
P
I
--------------------------
S
-
S
P
GVDVP
A
E
Q
L
E
E
SATVK
G
A
D
L
F
PD
V
A
R
G
Q
A
A
V
L
--
A
S
G
-
D
V
D
A
-
L
Y
S
W
--
L
P
W
A
--
G
E
-
L
Q
A
T
G
A
-
R
P
V
V
D
L
G
L
D
-------
E
R
N
A
Y
------
A
---
S
------------
V
W
T
V
S
S
G
L
V
R
Q
R
P
G
L
V
Q
R
L
V
D
A
A
V
--
D
A
G
L
W
A
R
--
D
H
-
S
D
A
V
T
S
L
H
A
--
A
N
--
L
--
G
---
V
S
--
T
G
A
V
G
Q
G
F
G
-
A
--
D
-
F
Q
---
Q
------
R
------
L
-------
V
P
R
---
L
D
H
D
-------------
A
L
A
L
L
E
R
T
Q
Q
F
-
L
L
T
N
--
N
-
L
L
Q
E
P
-------
V
A
-
L
----
D
Q
W
A
A
P
----
E
F
L
N
N
S
L
N
R
---------------------------------------
32
HHSearch
65.75
13%
-82
- C3 -
2G29
1
NRTA_SYNY3
A:
[28-378]
----------------------------
N
A
P
E
V
T
T
A
K
L
G
F
I
A
L
T
D
----
A
--
A
P
L
I
I
A
K
----
E
K
-
G
F
Y
A
-------
K
Y
--
G
M
P
D
-
V
E
V
--
L
K
Q
A
----
S
W
G
T
T
R
D
N
L
V
----
L
G
S
A
S
G
G
I
D
G
A
H
I
L
T
P
M
-
P
Y
L
-----
I
T
-
M
GTVTD
G
K
----------------
P
--
T
-
P
M
Y
I
L
A
R
L
N
---
V
N
-
G
-
Q
G
I
Q
L
G
N
N
YKDLKVGTDA----
A
P
-
L
K
E
A
-
F
A
K
-
V
T
-
D
P
K
V
A
M
--------------------------
T
F
P
-
G
-------
G
T
H
-------------------
D
M
-
W
I
R
Y
W
L
A
A
G
G
M
-
E
-----------
P
G
K
D
F
-------
S
T
I
V
V
--------------------------
P
-
P
A
--------------------------
Q
M
V
A
N
V
--
K
V
N
-
A
M
E
S
-
F
C
V
G
--
E
P
W
P
--
L
Q
-
T
V
N
Q
G
V
G
Y
Q
A
L
T
T
G
Q
L
-------
W
K
D
H
P
------
E
---
K
------------
A
F
G
M
R
A
D
W
V
D
Q
N
P
K
A
A
K
A
L
L
M
A
V
M
--
E
A
Q
Q
W
C
D
Q
A
E
N
-
K
E
E
M
C
Q
I
L
S
--
K
R
EW
F
--
K
---
V
P
--
F
E
D
I
I
D
R
S
K
G
I
--
Y
-
N
F
G
--
N
------
G
Q
E
T
F
E
D
Q
EIMQKYW
V
D
N
---
A
S
Y
P
-------------
Y
K
S
H
D
Q
W
F
L
T
E
-
N
I
R
W
--
G
-
Y
L
P
A
S
-------
T
D
-
T
K
A
I
V
D
K
V
N
R
E
----
D
L
W
R
E
A
A
Q
A
L
E
V
P
A
D
Q
I
P
S
S
----------------------------
33
HHSearch
65.47
16%
-78
- C3 -
2I49
-
CMPA_SYNY3
A:
[55-417]
-----------------------------
M
P
E
T
A
N
I
K
L
G
Y
I
P
I
V
E
----
A
--
A
P
L
I
I
A
Q
----
E
K
-
G
F
F
A
-------
K
Y
--
G
M
-
T
G
V
E
V
--
S
K
Q
A
----
N
W
A
----
S
A
R
D
N
V
T
I
G
S
Q
G
G
G
I
D
G
G
Q
W
Q
-
M
P
M
P
H
L
I
T
E
GI
I
T
-
N
-----
G
N
----------------
K
--
V
-
P
M
Y
V
L
A
Q
L
I
---
T
Q
-
G
-
N
G
I
A
V
A
P
M
HEGKGVNLDITKA
A
D
Y
-
I
-
K
G
-
F
N
K
-
T
N
-
G
R
K
F
K
A
A
H
T-----------------------
F
-
P
-
N
-------
V
N
Q
-------------------
D
F
-
W
I
R
Y
W
F
A
A
G
G
V
-
D
-----------
P
D
T
D
I
-------
D
L
L
A
V
--------------------------
P
-
P
A
--------------------------
E
T
V
Q
G
M
--
R
N
G
-
T
M
D
A
-
F
S
T
G
--
D
P
W
P
--
Y
R
-
I
V
T
E
N
I
G
Y
M
A
G
L
T
A
Q
I
-------
W
P
Y
H
P
------
E
---
E
------------
Y
L
A
I
R
A
D
W
V
D
K
N
P
K
A
T
K
A
L
L
K
G
I
M
--
E
A
Q
Q
W
I
D
D
P
K
N
-
R
P
E
V
V
Q
I
V
S
GR
N
Y
--
F
--
N
---
V
P
--
T
T
I
L
E
S
P
F
K
-
G
--
Q
Y
T
M
G
--
D
G
Q
P
A
I
D
D
------
F
QKGPLYW
K
D
G
IGN
V
S
Y
P
-------------
Y
K
S
H
D
L
W
F
L
T
E
-
S
I
R
W
--
G
-
F
H
K
N
A
IPD
L
D
T
A
Q
K
I
I
----
D
K
V
N
R
E
----
D
L
W
R
E
A
A
T
E
A
G
F
T
A
D
I
P
S
S
T
----------------------------
53
Fugue
63.60
16%
-76
- C3 -
2G29
1
NRTA_SYNY3
A:
[28-412]
------------
N
A
P
E
V
T
T
A
K
L
G
F
I
A
L
T
D
A
A
P
---
L
I
I
A
K
E
-----------------------
K
-
G
F
Y
A
K
---
Y
G
M
P
D
--
V
E
-
V
-
L
K
Q
--
A
S
W
G
-
T
--
T
R
D
----
N
L
V
----
L
G
S
A
S
G
G
I
D
G
A
H
I
L
-
T
P
-
M
P
Y
-----
L
I
-
T
-----
M
G
TVTDG
K
P
T
P
M
Y
I
LARL
N
--
V
-
N
G
Q
G
I
Q
L
G
N
-
N
-
Y
K
-
D
-
L
K
V
G
T
D
A
A
--------------
P
L
-
K
-
E
A
-
F
A
K
-
V
T
-
D
P
K
V
A
M
T
-------------------------
F
-
P
-
G
-------
G
T
H
-------------------
D
M
-
W
I
R
Y
W
L
A
A
G
G
M
E
P
-----------
G
-
K
D
F
-------
S
T
I
V
V
--------------------------
P
-
P
A
--------------------------
Q
M
V
A
N
V
--
K
V
N
-
A
M
E
S
F
C
V
G
E
--
P
W
-
P
--
L
Q
-
T
V
N
Q
G
V
G
Y
Q
A
L
T
T
G
Q
L
------
W
K
D
H
P
E
------
K
---
A
------------
F
G
M
R
-
A
D
W
V
D
Q
N
P
K
A
A
K
A
L
L
M
A
V
M
--
E
A
Q
Q
W
C
D
Q
A
E
N
-
K
E
E
M
C
Q
I
L
S
--
K
R
--
E
WF
K
---
V
P
--
F
E
D
I
I
D
R
S
K
-
G
--
I
Y
N
F
G
--
N
------
G
------
Q
-------
E
T
F
---
E
D
Q
E
IMQKYWVDNASYP
Y
K
S
H
D
Q
W
F
L
T
E
-
N
I
R
W
--
G
-
Y
L
P
A
S
-------
T
D
-
T
----
K
A
I
V
D
K
VNR
E
D
L
W
R
E
A
A
Q
A
L
E
V
P
A
D
Q
I
P
S
S
PSR
G
I
E
T
F
FDG
I
T
F
D
PEN
P
Q
A
Y
L
D
S
LKI
31
HHSearch
62.93
13%
-79
- C3 -
3IX1
1
THIY_BACHD
A:
[4-300]
--------------------------------
T
V
E
V
M
L
D
W
Y
P
N
A
----
V
H
--
T
F
L
Y
V
A
I
----
E
N
-
G
Y
F
A
-------
E
E
--
G
L
-
D
-
V
D
I
--
V
F
P
T
----
N
P
T
----
D
P
I
----
Q
L
T
A
S
G
A
I
P
L
A
L
S
Y
-
Q
P
-
D
V
I
-----
L
A
-
R
-----
S
K
----------------
D
--
L
-
P
V
V
S
V
A
S
V
V
-
R
-
S
P
-
L
-
N
H
V
M
F
L
A
E
--------------
Q
D
-
F
-
D
S
-
P
A
D
-
L
V
-
G
L
T
V
G
Y
--------------------------
P
-
G
-
I
-------
P
V
N
-------------------
E
P
-
I
L
K
T
M
V
E
A
A
G
G
-
D
-----------
Y
-
E
Q
V
-------
H
L
M
D
V
--------------------------
G
-
F
---------------------------
E
L
G
A
S
I
--
V
S
G
-
R
A
D
A
-
V
V
G
T
--
Y
I
N
H
E
Y
P
V
-
L
K
H
E
G
H
D
I
S
Y
F
N
P
V
D
Y
------
G
V
P
E
Y
D
------
E
---
L
------------
V
L
I
S
N
E
A
Y
V
E
E
S
G
E
V
L
A
A
F
W
R
A
A
L
--
K
G
Y
E
W
M
V
--
E
N
-
P
D
E
A
L
N
V
L
L
--
T
N
--
Q
--
D
EAN
F
P
L
I
Q
E
V
E
E
E
S
L
S
-
I
--
L
L
E
K
M
--
E
------
N
------
P
-------
N
G
P
---
F
G
G
Q
-------------
D
A
E
S
W
E
E
V
I
S
W
-
L
D
A
H
--
D
-
W
L
E
Q
P
-------
V
V
-
A
----
E
D
A
F
S
S
----
I
T
----------------------------------------------
48
Fugue
59.14
16%
-60
- C3 -
3IX1
1
THIY_BACHD
A:
[1-301]
-------------------------------
A
L
E
T
V
E
V
M
L
-
D
W
Y
P
N
A
V
H
T
F
L
Y
V
A
I
E
------------
N
G
---
Y
F
A
E
E
--
G
L
-
D
-
V
D
I
--
V
F
P
--
T
--
N
P
T
----
D
P
I
----
Q
L
T
A
S
G
A
I
P
L
A
L
S
Y
-
Q
P
-
D
V
I
-----
L
A
-
R
-----
S
K
----------------
D
--
L
-
P
V
V
S
V
A
S
V
V
-
R
-
S
P
-
L
-
N
H
V
M
F
L
A
E
--------------
Q
D
-
F
-
D
S
-
P
A
D
-
L
V
-
G
L
T
V
G
Y
--------------------------
P
-
G
-
I
-------
P
V
N
-------------------
E
P
-
I
L
K
T
M
V
E
A
A
G
G
-
D
-----------
Y
-
E
Q
V
-------
H
L
M
D
V
--------------------------
G
-
F
E
---------------------------
L
G
A
S
I
--
V
S
G
-
R
A
D
A
-
V
V
G
T
--
Y
I
-
N
--
H
E
-
Y
P
V
L
K
H
E
G
H
D
I
S
Y
F
N
P
------
V
D
Y
G
V
P
------
E
YDE
L
------------
V
L
I
S
N
E
A
Y
V
E
E
S
G
E
V
L
A
A
F
W
R
A
A
L
--
K
G
Y
E
W
M
V
E
--
N
-
P
D
E
A
L
N
V
L
L
--
T
N
--
Q
--
D
----------------------
E
A
N
--
F
------
P
------
L
-------
I
Q
E
---
V
E
E
E
-------------
S
L
S
I
L
L
E
K
M
E
N
P
N
G
P
F
--
G
-----
G
-------
Q
D
-
A
----
E
S
W
E
E
V
----
I
S
W
L
D
A
H
D
W
L
E
Q
P
V
V
A
E
D
A
F
SSIT------------------------
30
HHSearch
59.12
13%
-67
- C3 -
2X7Q
3
?
A:
[14-311]
--------------------------------
L
P
T
L
K
V
A
Y
I
P
E
H
F
----
S
--
T
P
L
F
F
A
Q
----
Q
Q
-
G
Y
Y
K
-------
A
H
--
D
L
-
S
-
I
E
F
--
V
K
V
P
----
E
G
S
G
---
R
L
I
----
N
L
L
N
S
N
E
V
D
I
A
I
G
L
-
T
E
-
A
F
I
-----
A
D
-
I
-----
A
K
----------------
G
--
N
E
N
I
H
V
L
D
T
Y
V
---
K
S
-
P
-
L
L
W
A
V
S
T
G
--------------
S
N
-
R
-
D
D
-
V
T
D
-
A
K
Q
L
K
R
I
G
V
--------------------------
S
-
R
I
G
-------
S
G
S
-------------------
Y
V
-
M
S
F
V
L
A
H
Q
L
G
V
-
P
-----------
S
F
D
Q
F
-------
Q
V
L
S
N
----------------------------
F
K
--------------------------
N
L
R
D
S
V
N
L
K
D
G
V
E
G
S
D
-
A
F
M
W
--
E
Y
F
T
--
S
K
-
K
Y
Y
D
N
--
H
E
I
K
Q
I
D
Q
I
-------
Y
T
P
W
S
------
S
---
W
------------
V
V
A
T
S
S
D
S
L
Q
A
K
S
D
V
I
K
N
F
I
D
A
V
N
--
Q
G
I
Q
Y
Y
N
--
E
H
-
V
D
E
A
I
E
Y
I
S
--
S
N
--
L
--
D
---
Y
S
--
A
E
D
A
K
E
W
T
K
-
T
--
V
-
E
F
N
--
S
------
R
------
I
-------
G
-
K
---
T
P
L
D
-------------
W
D
T
I
V
V
K
T
K
D
T
-
L
K
L
A
--
G
-
V
L
A
E
S
-------
D
D
---------
V
I
L
----
K
R
L
N
S
N
V
K
K
T
N
L
Q
L
D
G
D
L
E
-----------------------------
50
Fugue
58.68
13%
-56
- C3 -
4ESW
1
THI5_CANAW
A:
[1-342]
----------------------------
G
S
H
M
S
T
N
K
I
T
F
L
L
N
W
E
A
A
P
Y
H
I
P
V
Y
L
A
N
I
K
------------
G
---
Y
F
K
D
E
--
N
L
-
D
-
I
A
I
--
L
E
P
--
S
--
N
P
S
----
D
V
T
----
E
L
V
G
S
G
K
V
D
M
G
L
K
A
-
M
V
-
G
T
L
-----
A
A
-
K
-----
A
R
----------------
G
--
F
-
P
V
T
S
I
G
S
L
L
-
D
-
E
P
-
F
-
T
G
I
C
Y
L
E
G
--------------
S
G
-
I
-
T
S
D
F
Q
S
-
L
K
-
G
K
R
I
G
Y
--------------------------
V
---
G
-------
E
F
G
-------------------
K
I
-
Q
V
D
E
L
T
K
H
Y
G
M
-
T
-----------
P
-
D
D
Y
-------
V
A
V
R
C
--------------------------
G
--
M
--------------------------
N
V
A
K
Y
I
--
L
E
G
-
T
I
D
C
-
G
I
G
I
--
E
C
-
I
--
Q
Q
-
V
E
L
E
E
A
L
K
E
Q
G
K
D
S
N
D
------
A
K
M
L
R
I
------
D
---
K
L
A
ELGCCCFCTI
L
Y
I
A
N
D
K
F
I
A
E
N
P
Q
A
V
K
K
F
L
K
A
I
K
--
R
A
T
D
Y
M
L
A
H
-
P
-
R
E
A
W
A
E
Y
G
N
--
F
K
--
P
--
T
---
M
Q
--
T
D
L
N
T
K
K
F
Q
-
R
--
C
-
Y
A
Y
--
F
------
S
------
E
-------
S
L
Y
---
N
V
H
R
-------------
D
W
R
K
V
N
N
Y
G
K
R
-
L
D
I
L
--
P
E
N
Y
V
P
N
-------
Y
T
-
N
----
E
Y
L
S
W
P
----
E
P
K
E
V
D
D
P
E
K
A
Q
D
L
M
L
K
H
Q
E
E
C
K
T
CG
G
Y
K
R
L
VLA--------------
52
Fugue
57.89
19%
-56
- C3 -
1US5
2
?
A:
[17-313]
----
A
Q
E
F
I
T
I
G
S
G
S
T
T
----
G
V
Y
F
P
V
A
T
G
I
A
-
K
L
V
N
D
A
N
V
G
I
R
A
N
A
R
S
T
G
G
S
V
A
N
I
N
A
----
I
N
-
A
---------------------------------
G
E
----
F
E
M
----
A
L
A
Q
N
D
I
A
Y
Y
A
Y
Q
G
-
C
C
-
I
P
A
-----
F
E
-
G
-----
K
P
----------------
V
--
K
-
T
I
R
A
L
A
A
L
Y
-
P
-
E
V
-
V
-
H
V
V
-
A
R
K
D
--------------
A
G
-
I
-
R
T
-
V
A
D
-
L
K
-
G
K
R
V
V
V
G-------------------------
D
-
V
-
G
-------
S
G
T
-------------------
E
Q
-
N
A
R
Q
I
L
E
A
Y
G
L
-
T
-----------
F
-
D
D
L
G------
Q
A
I
R
V
--------------------------
S
-
A
S
--------------------------
Q
G
I
Q
L
M
--
Q
D
K
-
R
A
D
A
-
L
F
Y
T
--
V
G
-
L
--
G
A
-----------
S
A
I
Q
Q
L
------
A
L
T
T
P
I
------
A
---
L
------------
V
A
V
-
D
L
N
R
I
Q
A
I
A
K
K
Y
P
F
Y
V
G
F
N
I
--
P
G
G
T
Y
K
G
V
D
V
T
---------
T
--
P
T
--
V
--
A
---
V
Q
--
A
M
L
I
A
S
E
--------
R
L
S
--
E
------
E
------
T
-------
V
Y
K
---
F
M
K
A
-------------
V
F
G
N
L
E
A
F
K
K
I
-
H
P
N
L
--
E
-
R
F
F
G
L
-------
E
K
-
A
----
V
K
G
L
P
I
----
P
L
H
P
G
A
E
R
F
Y
K
E
A
G
V
L
K
-------------------------------
39
HHSearch
55.55
17%
-79
- C3 -
1P99
2
?
A:
[40-291]
----------------------------------
K
V
T
I
G
V
A
S
N
D
-----
T
--
K
A
W
E
--
K
----
V
K
-
E
L
A
K
-------
K
D
--
D
I
-
D
-
V
E
I
--
K
H
F
S
----
D
Y
N
----
L
P
N
----
K
A
L
N
D
G
D
I
D
M
N
A
F
Q
-
H
F
-
A
F
L
-----
D
Q
-
Y
-----
K
K
A
H
K-------------
G
--
T
-
K
I
S
A
L
S
T
T
V
---
L
A
-
P
-
L
G
I
Y
S
-----------------
D
K
-
I
-
K
D
-
V
K
K
-
V
K
D
G
A
K
V
V
I
--------------------------
P
-
N
-
D
-------
V
S
N
-------------------
Q
A
-
R
A
L
K
L
L
E
A
A
G
L
-
I
KLKKDFGLAGT
V
-
K
D
I
TSNPKHL
K
I
T
A
V
--------------------------
D
-
A
Q
--------------------------
Q
T
A
R
A
L
----
S
-
D
V
D
I
-
A
V
I
N
--
N
G
V
A
--
T
K
-
A
G
K
D
P
K
N
D
P
I
F
L
E
K
S
N
S-----
D
A
V
K
P
Y
------
I
---
N
------------
I
V
A
V
N
D
K
D
L
D
N
--
K
T
Y
A
K
I
V
E
L
Y
H
S
K
E
A
Q
K
A
L
Q
--
E
D
-
V
K
D
----
G
E
--
K
P
--
V
--
N
---
L
S
--
K
D
E
I
K
A
I
E
T
-
S
--
L
-
A
---------------------------------------------------------------------------------------------------------------------------------------------------