@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0202: (2015-12-26 )
MKPNPPINELVLLQAHQLAERIRLRQVSCREVMQAYLAHIERFNPRVNALVSLLPAERLLEEADARDGELARGEWRGWMHGLPHAIKDLSLTRGIRTTLGSPLYRDYIPERDGIMVERIRAAGAILIGKTNTPEFGLGSQTYNPLFGATACAYDERLSAGGSSGGAAAALALHLVPVADGSDMMGSLRNPAAFNNVIGFRPSQGRVPFDDSADLFFDQLGYEGPMGRSVRDTALLLSVQAGADRRAPLSIAEPGARFAAPLERDFEGTRLGWLGDLDGYLPMQDGILQMCQRALGDFRSLGCEIEEANLGFAPERLWECWRTLRHWLVAGSLGGVHADPAKRALLKPEALWEVENGLRLGADAVFRASVIRSDWYRAIGRLFERYDYLLLPSAQVFPFAKETPWPRSIEGVAMDTYHRWMEVVVPGSLSGCPVANVQAGFNAEGLPMGLQIIGPHQADFAVLQLAHAYERASRWFERQPSPLLAN
Atome Classification :
(20 SA)
.........10........20........30......---..40...---.....50........60........70........80........90.-.......100...--....110.......120.......130....-------------.-----..140----........150..-.....160.......170.......180.......190.......200.....------..210..--...---..220.......230.......240.....-..250..-.---.----...260........270---....-....--280.......290.......300.....---..310...--.--------.-----..320.-----......------------330.---...-----------------.------------------------.------------.------340------------------.-----.----------------.......350-----.-..--------....-----..360-------....-...-.370.--...-----...-------380.--......390.--.....-.400......---.410-....--.....420-........430.......440.......450.......460.......470.......480...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKPNPP
I
N
E
L
V
L
L
Q
A
H
Q
L
A
E
R
I
R
L
R
Q
V
S
C
R
E
V
M
Q
A
Y
L
---
A
H
I
E
RFN---
P
R
V
N
A
L
V
S
L
L
P
A
E
R
L
L
E
E
ADARDGELA
R
G
E
W
R
G
W
M
HG
L
P
H
A
I
K
D
L
S
L
T
-
R
G
I
R
T
TLG
S
P
L
Y
R
--
D
YIPERD
G
I
M
V
E
R
I
RAA
G
A
I
L
I
GKTNTPEFG-------------L-----GSQT-----YNPLFGA
T
A
C
A
Y
D
-
E
R
LSAGGSSG
G
A
A
A
A
L
A
L
H
L
V
PVADG
S
D
M
M
G
SLRNP
A
A
FNNVIGFRPSQGRVP------FDD
S
A
D
L
--
F
F
D
---QLGYEGPMGRSVR
D
T
A
L
L
L
S
V
QAGADRRAP-LSIAEPG-
A
---
R
----
F
A
A
P
L
-ERDFEG
T
R
L
G----WLGD-LDGY--LP
M
Q
D
G
I
L
Q
M
C
Q
R
A
L
G
D
F
R
S
LG
C
E
I
EEA---NLGF
A
P
E
R
--
L
--------
W
-----
E
C
W
R
T
L
-----
R
H
W
L
V
A------------GSLG---GVH-----------------A------------------------
D
------------
P
------
A
--------------------
K
-----
R
----------------ALLK
P
E
A
L
-------
W
-
E
V
--------ENGL-----RL
G
A
--------
D
A
V
F
-
R
A
S
-
V
I
R
S
D
--
W
Y
R
-----
A
I
G
-------
R
L
F
E
--RYD
Y
L
LLPSA--QVFPF-AKETPWPRSI---
E
G
---
V
A
M
D
--
T
Y
H
R
W
M
E
--
V
VVPGSLSGCPVA
N
V
QAGFNAEGLPM
G
L
Q
I
IGPHQ
A
D
F
A
V
L
Q
L
A
H
A
Y
E
R
A
S
R
W
F
ERQPSPLLAN
86
HHSearch
87.32
26%
-65
- C2 -
3H0L
-
GATA_AQUAE
A:
[2-475]
---------
L
W
K
K
S
L
S
E
L
R
E
L
L
K
R
G
E
V
S
P
K
E
V
V
E
S
F
Y
---
D
R
Y
N
Q
T
E
---
E
K
V
K
A
Y
I
T
P
L
Y
G
K
A
L
-
K
Q
A
E
S
L
K
E
------
R
E
L
P
L
F
G
I
P
I
A
V
K
D
N
I
L
V
-
E
G
E
K
T
T
C
A
S
K
I
L
E
--
N
F
V
A
P
Y
D
A
T
V
I
E
R
L
K
K
A
G
A
L
I
V
G
K
T
N
L
D
E
F
A
-------------
M
-----
G
S
S
T
-----
E
Y
S
A
F
F
P
T
K
N
P
W
D
-
L
E
R
V
P
G
G
S
S
G
G
S
A
A
S
V
A
V
L
S
A
P
V
S
L
G
S
D
T
G
G
S
I
R
Q
P
A
S
F
C
G
V
I
G
I
K
P
T
Y
G
R
V
S
------
R
Y
G
L
V
A
F
--
A
-
S
---
S
L
D
Q
I
G
V
F
G
R
R
T
E
D
V
A
L
V
L
E
V
I
S
G
W
D
E
K
D
S
-
T
S
A
K
V
P
V
-
P
---
E
----
W
S
E
E
V
-
K
K
E
V
K
G
L
K
I
G
----
L
P
K
E
-
F
F
-
E
--
Y
E
L
Q
P
Q
V
K
E
A
F
E
N
F
I
K
E
L
E
K
E
G
F
E
I
K
E
V
---
S
L
P
H
V
-
K
Y
--
S
--------
I
-----
P
T
Y
Y
I
I
-----
A
P
S
E
A
S
------------
S
N
L
A
---
R
Y
D
GVRYGYRAKEYKD
I
F
E
M
Y
------------------------
A
------------
R
------
T
--------------------
R
-----
D
----------------
E
G
F
G
P
E
V
K
-------
R
-
R
I
--------
M
L
G
T
F
A
L
SA
G
Y
Y
D
--------
A
Y
Y
L
-
K
A
Q
-
K
V
R
R
L
--
I
T
N
-----
D
F
L
-------
K
A
F
E
--
E
V
D
V
I
A
S
P
T
T
--
P
T
L
P
F
-
K
F
G
E
R
L
E
N
P
------------
I
--
E
M
Y
L
S
D
I
--
L
T
V
P
A
N
L
A
G
L
P
A
I
S
I
P
I
A
W
K
-
D
G
L
P
V
G
G
Q
L
I
G
K
H
W
D
E
T
T
L
L
Q
I
S
Y
L
W
E
Q
K
F
K
H
Y
E
K
I
P
L
T
----
88
HHSearch
86.31
35%
-71
- C2 -
3KFU
-
GATA_THET8
E:
[2-467]
-------------
L
A
H
E
I
R
A
R
V
A
R
G
E
V
S
P
L
E
V
A
Q
A
Y
L
---
K
R
V
Q
E
L
D
---
P
G
L
G
A
F
L
S
L
N
E
-
R
L
L
-
E
E
A
E
A
V
D
-------
P
G
L
P
L
A
G
L
V
V
A
V
K
D
N
I
A
T
-
R
G
L
R
T
T
A
G
S
R
L
L
E
--
N
F
V
P
P
Y
E
A
T
A
V
A
R
L
K
A
L
G
A
L
V
L
G
K
T
N
L
D
E
F
G
-------------
M
-----
G
S
S
T
-----
E
H
S
A
F
F
P
T
K
N
P
F
D
-
P
D
R
V
P
G
G
S
S
G
G
S
A
A
A
L
A
A
D
L
A
P
L
A
L
G
S
D
T
G
G
S
V
R
Q
P
A
A
F
C
G
V
Y
G
L
K
P
T
Y
G
R
V
S
------
R
F
G
L
I
A
Y
--
A
-
S
---
S
L
D
Q
I
G
P
M
A
R
S
V
R
D
L
A
L
L
M
D
A
A
A
G
P
D
P
L
D
A
-
T
S
L
D
L
P
P
-----
R
----
F
Q
E
A
L
-
E
G
P
L
P
P
L
R
L
G
----
V
V
R
E
-
A
L
----
A
G
N
S
P
G
V
E
R
A
L
E
E
A
L
K
V
F
R
E
L
G
L
S
V
R
E
V
---
S
W
P
S
L
-
P
Q
--
A
--------
L
-----
A
A
Y
Y
I
L
-----
A
P
A
E
A
S
------------
S
N
L
A
---
R
Y
D
GTL--------------
Y
------------------------
G
RRAAGEEVEGMM
E
------
A
--------------------
T
-----
R
----------------
A
L
F
G
L
E
V
K
-------
R
-
R
V
--------
L
V
G
T
FVLSS
G
Y
Y
E
--------
A
Y
Y
G
-
R
A
Q
-
A
F
R
R
R
--
L
K
A
-----
E
A
Q
-------
A
L
F
R
--
E
V
D
L
L
L
L
P
T
T
--
P
H
P
A
F
-
P
F
G
A
R
R
D
P
L
---------------
A
M
Y
R
E
D
L
--
Y
T
V
G
A
N
L
T
G
L
P
A
L
S
F
P
A
G
F
E
-
G
H
L
P
V
G
L
Q
L
L
A
P
W
G
E
D
E
R
L
L
R
A
A
L
A
F
E
E
A
T
A
R
A
H
L
K
A
P
L
G
E
--
12
PsiBlast_PDB
86.17
26%
-66
- C2 -
3H0R
1
GATA_AQUAE
A:
[9-476]
----------------
E
L
R
E
L
L
K
R
G
E
V
S
P
K
E
V
V
E
S
F
Y
---
D
R
Y
N
Q
T
E
---
E
K
V
K
A
Y
I
T
P
L
Y
G
K
A
L
K
Q
A
E
S
L
K
E
R
E
L
P
-------
L
F
G
I
P
I
A
V
K
D
N
I
L
V
-
E
G
E
K
T
T
C
A
S
K
I
L
E
--
N
F
V
A
P
Y
D
A
T
V
I
E
R
L
K
K
A
G
A
L
I
V
G
K
T
N
L
D
E
F
A
-------------
M
-----
G
S
S
T
-----
E
Y
S
A
F
F
P
T
K
N
P
W
D
L
E
R
V
P
G
G
S
S
G
G
S
A
A
S
V
A
V
L
S
-
A
P
V
S
L
G
S
D
T
G
G
S
I
R
Q
P
A
S
F
C
G
V
I
G
I
K
P
T
Y
G
R
V
S
RYGLVA
F
A
S
S
------
L
D
---
Q
I
G
V
---
F
G
R
R
T
E
D
V
A
L
V
L
E
V
I
S
G
W
D
E
K
D
S
-
T
S
A
K
V
P
V
-
P
---
E
----
W
S
E
E
V
-
K
K
E
V
K
G
L
K
I
G
----
L
P
K
E
-
F
F
E
Y
---
E
L
Q
P
Q
V
K
E
A
F
E
N
F
I
K
E
L
E
K
E
G
F
E
I
K
E
V
---
S
L
P
H
V
K
---------------------
Y
S
I
P
-----
T
Y
Y
I
I
A
P
S
E
A
S
S
N
L
ARYD
G
V
R
Y
---
G
Y
R
-----------------
A
------------------------
K
------------
E
------
Y
--------------------
K
D
I
F
E
M
Y
----------------
A
R
T
R
D
E
G
F
-------
G
P
E
V
--------
K
R
R
I
-----
M
L
G
T
F
A
L
SAGYY
D
A
Y
Y
L
K
A
Q
-
K
V
R
R
L
--
I
T
N
-----
D
F
L
-------
K
A
F
E
--
E
V
D
V
I
A
S
P
T
T
--
P
T
L
P
F
-
K
F
G
E
R
L
E
N
P
I
---
E
M
---
Y
L
S
D
--
I
--------
L
T
V
P
A
N
L
A
G
L
P
A
I
S
I
P
I
A
W
K
-
D
G
L
P
V
G
G
Q
L
I
G
K
H
W
D
E
T
T
L
L
Q
I
S
Y
L
W
E
Q
K
F
K
H
Y
E
K
I
P
L
T
----
11
PsiBlast_PDB
85.84
26%
-66
- C2 -
3H0M
1
GATA_AQUAE
A:
[9-476]
----------------
E
L
R
E
L
L
K
R
G
E
V
S
P
K
E
V
V
E
S
F
Y
---
D
R
Y
N
Q
T
E
---
E
K
V
K
A
Y
I
T
P
L
Y
G
K
A
L
K
Q
A
E
S
L
K
E
R
E
L
P
-------
L
F
G
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P
I
A
V
K
D
N
I
L
V
-
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G
E
K
T
T
C
A
S
K
I
L
E
--
N
F
V
A
P
Y
D
A
T
V
I
E
R
L
K
K
A
G
A
L
I
V
G
K
T
N
L
D
E
F
A
-------------
M
-----
G
S
S
T
-----
E
Y
S
A
F
F
P
T
K
N
P
W
D
L
E
R
V
P
G
G
S
S
G
G
S
A
A
S
V
A
V
L
S
-
A
P
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S
L
G
S
D
T
G
G
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I
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Q
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A
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F
C
G
V
I
G
I
K
P
T
Y
G
R
V
S
RYGLVA
F
A
S
S
------
L
D
---
Q
I
G
V
---
F
G
R
R
T
E
D
V
A
L
V
L
E
V
I
S
G
W
D
E
K
D
S
-
T
S
A
K
V
P
V
-
P
---
E
----
W
S
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E
V
-
K
K
E
V
K
G
L
K
I
G
----
L
P
K
E
-
F
F
E
Y
---
E
L
Q
P
Q
V
K
E
A
F
E
N
F
I
K
E
L
E
K
E
G
F
E
I
K
E
V
---
S
L
P
H
V
K
---------------------
Y
S
I
P
-----
T
Y
Y
I
I
A
P
S
E
A
S
S
N
L
ARYD
G
V
R
Y
---
G
Y
R
-----------------
A
------------------------
K
------------
E
------
Y
--------------------
K
D
I
F
E
M
Y
----------------
A
R
T
R
D
E
G
F
-------
G
P
E
V
--------
K
R
R
I
-----
M
L
G
T
F
A
L
SAGYY
D
A
Y
Y
L
K
A
Q
-
K
V
R
R
L
--
I
T
N
-----
D
F
L
-------
K
A
F
E
--
E
V
D
V
I
A
S
P
T
T
--
P
T
L
P
F
-
K
F
G
E
R
L
E
N
P
I
---
E
M
---
Y
L
S
D
--
I
--------
L
T
V
P
A
N
L
A
G
L
P
A
I
S
I
P
I
A
W
K
-
D
G
L
P
V
G
G
Q
L
I
G
K
H
W
D
E
T
T
L
L
Q
I
S
Y
L
W
E
Q
K
F
K
H
Y
E
K
I
P
L
T
----
10
PsiBlast_PDB
85.73
26%
-66
- C2 -
3H0L
-
GATA_AQUAE
A:
[9-476]
----------------
E
L
R
E
L
L
K
R
G
E
V
S
P
K
E
V
V
E
S
F
Y
---
D
R
Y
N
Q
T
E
---
E
K
V
K
A
Y
I
T
P
L
Y
G
K
A
L
K
Q
A
E
S
L
K
E
R
E
L
P
-------
L
F
G
I
P
I
A
V
K
D
N
I
L
V
-
E
G
E
K
T
T
C
A
S
K
I
L
E
--
N
F
V
A
P
Y
D
A
T
V
I
E
R
L
K
K
A
G
A
L
I
V
G
K
T
N
L
D
E
F
A
-------------
M
-----
G
S
S
T
-----
E
Y
S
A
F
F
P
T
K
N
P
W
D
L
E
R
V
P
G
G
S
S
G
G
S
A
A
S
V
A
V
L
S
-
A
P
V
S
L
G
S
D
T
G
G
S
I
R
Q
P
A
S
F
C
G
V
I
G
I
K
P
T
Y
G
R
V
S
RYGLVA
F
A
S
S
------
L
D
---
Q
I
G
V
---
F
G
R
R
T
E
D
V
A
L
V
L
E
V
I
S
G
W
D
E
K
D
S
-
T
S
A
K
V
P
V
-
P
---
E
----
W
S
E
E
V
-
K
K
E
V
K
G
L
K
I
G
----
L
P
K
E
-
F
F
E
Y
---
E
L
Q
P
Q
V
K
E
A
F
E
N
F
I
K
E
L
E
K
E
G
F
E
I
K
E
V
---
S
L
P
H
V
K
---------------------
Y
S
I
P
-----
T
Y
Y
I
I
A
P
S
E
A
S
S
N
L
ARYD
G
V
R
Y
---
G
Y
R
-----------------
A
------------------------
K
------------
E
------
Y
--------------------
K
D
I
F
E
M
Y
----------------
A
R
T
R
D
E
G
F
-------
G
P
E
V
--------
K
R
R
I
-----
M
L
G
T
F
A
L
SAGYY
D
A
Y
Y
L
K
A
Q
-
K
V
R
R
L
--
I
T
N
-----
D
F
L
-------
K
A
F
E
--
E
V
D
V
I
A
S
P
T
T
--
P
T
L
P
F
-
K
F
G
E
R
L
E
N
P
I
---
E
M
---
Y
L
S
D
--
I
--------
L
T
V
P
A
N
L
A
G
L
P
A
I
S
I
P
I
A
W
K
-
D
G
L
P
V
G
G
Q
L
I
G
K
H
W
D
E
T
T
L
L
Q
I
S
Y
L
W
E
Q
K
F
K
H
Y
E
K
I
P
L
T
----
1
PsiBlast_PDB
84.91
36%
-67
- C2 -
3KFU
-
GATA_THET8
E:
[3-458]
--------------
A
H
E
I
R
A
R
V
A
R
G
E
V
S
P
L
E
V
A
Q
A
Y
L
---
K
R
V
Q
E
L
D
---
P
G
L
G
A
F
L
S
L
--
N
E
R
L
L
E
E
A
E
A
V
D
P
G
L
P
-------
L
A
G
L
V
V
A
V
K
D
N
I
A
T
-
R
G
L
R
T
T
A
G
S
R
L
L
E
--
N
F
V
P
P
Y
E
A
T
A
V
A
R
L
K
A
L
G
A
L
V
L
G
K
T
N
L
D
E
F
G
-------------
M
-----
G
S
S
T
-----
E
H
S
A
F
F
P
T
K
N
P
F
D
-
P
D
R
V
P
G
G
S
S
G
G
S
A
A
A
L
A
A
D
L
A
P
L
A
L
G
S
D
T
G
G
S
V
R
Q
P
A
A
F
C
G
V
Y
G
L
K
P
T
Y
G
R
V
S
R-----
F
G
L
I
A
----
Y
A
S
---
S
L
D
Q
I
G
P
M
A
R
S
V
R
D
L
A
L
L
M
D
A
A
A
G
P
D
P
L
D
A
-
T
S
L
D
L
P
--
P
---
R
----
F
Q
E
A
L
-
E
G
P
L
P
P
L
R
L
G
----
V
V
R
E
A
L
A
G
N
--
S
P
---
G
V
E
R
A
L
E
E
A
L
K
V
F
R
E
L
G
L
S
V
R
E
V
---
S
W
P
S
L
P
Q
A
--
L
AAYYILAP
A
-----
E
A
S
S
N
L
-----
A
R
Y
--
D
------------
G
T
L
Y
---
G
R
R
-----------------
A
------------------------
A
GEEVEGMM----
E
------
A
--------------------
T
-----
R
----------------
A
L
F
G
L
E
V
K
-------
R
-
R
V
--------
L
V
G
T
-----
F
V
L
S
--------
S
G
Y
Y
-
E
A
Y
-
Y
G
R
A
Q
--
A
F
R
RRLKA
E
A
Q
-------
A
L
F
R
--
E
V
D
L
L
L
L
P
T
------------
T
P
H
P
A
F
P
---
F
G
---
A
R
R
D
--
P
L
A
M
Y
R
E
DL
Y
T
V
G
A
N
L
T
G
L
P
A
L
S
F
P
A
G
F
E
G
H
-
L
P
V
G
L
Q
L
L
A
P
W
G
E
D
E
R
L
L
R
A
A
L
A
F
E
E
A
T
A
R
A
H
L
K
A
P
L
G
E
--
85
HHSearch
84.18
25%
-67
* C2 *
3IP4
-
GATA_STAAM
A:
[2-484]
--------
S
I
R
Y
E
S
V
E
N
L
L
T
L
I
K
D
K
K
I
K
P
S
D
V
V
K
D
I
Y
---
D
A
I
E
E
T
D
---
P
T
I
K
S
F
L
A
L
D
K
E
N
A
I
-
K
K
A
Q
E
L
D
E
L
Q
A
K
D
Q
M
D
G
K
L
F
G
I
P
M
G
I
K
D
N
I
I
T
-
N
G
L
E
T
T
C
A
S
K
M
L
E
--
G
F
V
P
I
Y
E
S
T
V
M
E
K
L
H
K
E
N
A
V
L
I
G
K
L
N
M
D
E
F
A
-------------
M
-----
G
G
S
T
-----
E
T
S
Y
F
K
K
T
V
N
P
F
D
-
H
K
A
V
P
G
G
S
S
G
G
S
A
A
A
V
A
A
G
L
V
P
L
S
L
G
S
D
T
G
G
S
I
R
Q
P
A
A
Y
C
G
V
V
G
M
K
P
T
Y
G
R
V
S
------
R
F
G
L
V
A
F
--
A
-
S
---
S
L
D
Q
I
G
P
L
T
R
N
V
K
D
N
A
I
V
L
E
A
I
S
G
A
D
V
N
D
S
-
T
S
A
P
V
D
D
-
V
---
D
----
F
T
S
E
I
-
G
K
D
I
K
G
L
K
V
A
----
L
P
K
E
-
Y
L
-
G
--
E
G
V
A
D
D
V
K
E
A
V
Q
N
A
V
E
T
L
K
S
L
G
A
V
V
E
E
V
---
S
L
P
N
T
-
K
F
--
G
--------
I
-----
P
S
Y
Y
V
I
-----
A
S
S
E
A
S
------------
S
N
L
S
---
R
F
D
GIRYGYHSKEAHS
L
E
E
-
L
------------------------
Y
------------
K
M
-----
S
--------------------
R
-----
S
----------------
E
G
F
G
K
E
V
K
-------
R
-
R
I
--------
F
L
G
T
F
A
L
SS
G
Y
Y
D
--------
A
Y
Y
K
-
K
S
Q
-
K
V
R
T
L
--
I
K
N
-----
D
F
D
-------
K
V
F
E
--
N
Y
D
V
V
V
G
P
T
A
--
P
T
T
A
F
-
N
L
G
E
E
I
D
D
P
------------
L
--
T
M
Y
A
N
D
L
--
L
T
T
P
V
N
L
A
G
L
P
G
I
S
V
P
C
G
Q
S
-
N
G
R
P
I
G
L
Q
F
I
G
K
P
F
D
E
K
T
L
Y
R
V
A
Y
Q
Y
E
T
Q
Y
N
L
H
D
V
Y
E
K
L
----
91
HHSearch
83.56
29%
-64
- C2 -
1M22
1
?
A:
[6-487]
-------
F
P
Y
A
E
T
D
V
A
D
L
Q
A
R
M
T
A
G
E
L
D
S
T
T
L
T
Q
A
Y
L
---
Q
R
I
A
A
L
D
RTG
P
R
L
R
A
V
I
E
L
N
P
D
-
A
L
-
K
E
A
A
E
R
D
R
E
R
R
D
G
R
L
R
G
P
L
H
G
I
P
L
L
L
K
D
N
I
N
A
-
A
P
M
A
T
S
A
G
S
L
A
L
Q
--
G
F
R
-
P
D
D
A
Y
L
V
R
R
L
R
D
A
G
A
V
V
L
G
K
T
N
L
S
E
W
A
-------------
N
FRGND
S
I
S
G
-----
W
S
A
R
G
G
Q
T
R
N
P
Y
R
-
I
S
H
S
P
C
G
S
S
S
G
S
A
V
A
V
A
A
N
L
A
S
V
A
I
G
T
E
T
D
G
S
I
V
C
P
A
A
I
N
G
V
V
G
L
K
P
T
V
G
L
V
S
------
R
D
G
I
I
P
I
--
S
-
F
---
S
Q
D
T
A
G
P
M
A
R
S
V
A
D
A
A
A
V
L
T
A
I
A
G
R
D
D
A
D
P
-
A
T
A
T
M
P
G
-
R
AVY
D
----
Y
T
A
R
L
D
P
Q
G
L
R
G
K
R
I
G
----
L
L
Q
T
-
P
L
-
L
----
K
Y
R
G
M
P
P
L
I
E
Q
A
A
T
E
L
R
R
A
G
A
V
V
V
P
V
---
E
L
P
N
Q
-
G
A
--
W
--------
A
-----
E
A
E
R
T
L
-----
L
L
Y
E
F
K
------------
A
G
L
E
---
R
Y
F
------------------------------------------
N
------------
T
------
H
RAPLRS
L
A
D
L
I
A
F
N
Q
A
H
SKQ
E
-----
L
----------------
G
L
F
G
Q
E
L
L
-------
V
-
E
A
--------
D
A
T
A
-----
G
L
A
D
--------
P
A
Y
I
-
R
A
R
-
S
D
A
R
R
L
A
G
P
E
-----
G
I
D
-------
A
A
L
A
A
H
Q
L
D
A
L
V
A
P
T
T
--
G
V
A
W
P
-
I
R
S
---
D
--------------------
F
P
G
E
--
S
Y
S
A
A
A
V
A
G
Y
P
S
L
T
V
P
M
G
Q
I
-
D
G
L
P
V
G
L
L
F
M
G
T
A
W
S
E
P
K
L
I
E
M
A
Y
A
Y
E
Q
R
T
R
A
R
R
P
P
H
F
D
T
---
15
PsiBlast_PDB
82.86
29%
-56
- C2 -
1M21
1
?
A:
[16-485]
-----------------
L
Q
A
R
M
T
A
G
E
L
D
S
T
T
L
T
Q
A
Y
L
Q
R
I
A
A
L
D
R
T
G
---
P
R
L
R
A
V
I
E
L
N
P
--
D
A
L
K
E
A
A
E
R
D
R
E
R
R
D
G
R
L
R
G
P
L
H
G
I
P
L
L
L
K
D
N
I
N
A
-
A
P
M
A
T
S
A
G
S
L
A
L
Q
--
G
F
R
P
D
-
D
A
Y
L
V
R
R
L
R
D
A
G
A
V
V
L
G
K
T
N
L
S
E
W
A
NFRGNDSISGWSA
R
-----
G
G
Q
T
-----
R
N
P
--------
Y
R
-
I
S
H
S
P
C
G
S
S
S
G
S
A
V
A
V
A
A
N
L
A
S
V
A
I
G
T
E
T
D
G
S
I
V
C
P
A
A
I
N
G
V
V
G
L
K
P
T
V
G
L
V
S
------
R
D
G
I
I
P
I
--
S
F
S
---
Q
-
D
T
A
G
P
M
A
R
S
V
A
D
A
A
A
V
L
T
A
I
A
G
R
D
D
A
D
P
-
A
T
A
T
M
P
G
R
A
---
V
----
Y
D
Y
T
A
-
R
L
D
P
Q
G
L
R
G
K
----
R
I
G
L
-
L
Q
T
P
--
L
L
K
Y
R
G
M
P
P
L
I
E
Q
A
A
T
E
L
R
R
A
G
A
V
V
V
P
V
---
E
L
--
P
N
Q
G
--
A
--------
W
A
----
E
A
E
R
T
L
-----
L
L
Y
E
F
K
------------
A
G
L
E
R
Y
F
N
T
H
-----------------
R
------------------------
A
------------
P
------
L
--------------------
R
-----
S
L
A
D
L
I
A
F
N
Q
A
H
SKQEL
G
L
F
G
Q
E
L
L
-------
V
-
E
A
--------
D
A
T
A
-----
G
L
A
D
--------
P
A
Y
I
-
R
A
----
R
S
D
--
A
R
R
-----
L
A
G
P
EG
I
D
A
A
L
A
A
H
--
Q
L
D
A
L
V
A
P
T
T
--
G
V
A
--------
W
P
I
R
S
---
E
G
------
D
--
D
F
P
G
--
E
--
S
Y
S
A
A
A
V
A
G
Y
P
S
L
T
V
P
M
G
-
Q
I
D
G
L
P
V
G
L
L
F
M
G
T
A
W
S
E
P
K
L
I
E
M
A
Y
A
Y
E
Q
R
T
R
A
R
R
P
P
H
F
-----
4
PsiBlast_PDB
82.73
27%
-71
- C2 -
2DQN
1
GATA_STAAM
A:
[8-473]
--------------
V
E
N
L
L
T
L
I
K
D
K
K
I
K
P
S
D
V
V
K
D
I
Y
---
D
A
I
E
E
T
D
---
P
T
I
K
S
F
L
A
-
L
D
K
E
N
A
I
K
K
A
Q
E
L
D
E
L
Q
A
K
D
Q
M
D
G
K
L
F
G
I
P
M
G
I
K
D
N
I
I
T
-
N
G
L
E
T
T
C
A
S
K
M
L
E
--
G
F
V
P
I
Y
E
S
T
V
M
E
K
L
H
K
E
N
A
V
L
I
G
K
L
N
M
D
E
F
A
-------------
M
-----
G
G
S
T
-----
E
T
S
Y
F
K
K
T
V
N
P
F
D
-
H
K
A
V
P
G
G
S
S
G
G
S
A
A
A
V
A
A
G
L
V
P
L
S
L
G
S
D
T
G
G
S
I
R
Q
P
A
A
Y
C
G
V
V
G
M
K
P
T
Y
G
R
V
S
R-----
F
G
L
V
A
----
F
A
S
---
S
L
D
Q
I
G
P
L
T
R
N
V
K
D
N
A
I
V
L
E
A
I
S
G
A
D
V
N
D
S
-
T
S
A
P
V
D
D
-
V
---
D
----
F
T
S
E
I
-
G
K
D
I
K
G
L
K
V
A
L
P
KE
Y
L
G
E
--------
G
V
A
D
D
V
K
E
A
V
Q
N
A
V
E
T
L
K
S
L
G
A
V
V
E
E
V
S
LP
N
T
K
F
G
I
P
S
--
Y
--------
Y
V
I
A
S
S
E
A
S
S
N
L
-----
S
R
F
--
D
------------
G
I
R
Y
---
G
Y
H
-----------------
S
------------------------
K
------------
E
------
A
--------------------
H
-----
S
L
E
E
L
Y
-----------
K
M
S
R
S
E
G
F
G------
K
-
E
V
--------
K
R
R
I
-----
F
L
G
T
F
A
L
SSGYY
D
A
Y
Y
-
K
K
S
Q
K
V
R
T
L
--
I
K
N
-----
D
F
D
-------
K
V
F
E
--
N
Y
D
V
V
V
G
P
T
A
PT
T
A
F
N
L
-
G
E
E
I
D
D
P
L
T
M
---
Y
A
---
N
D
L
------------
L
T
T
P
V
N
L
A
G
L
P
G
I
S
V
P
C
G
-
Q
S
N
G
R
P
I
G
L
Q
F
I
G
K
P
F
D
E
K
T
L
Y
R
V
A
Y
Q
Y
E
T
Q
Y
N
L
H
D
V
Y
E
K
L
----
89
HHSearch
82.63
27%
-66
- C2 -
3A2Q
3
NYLA_FLASK
A:
[4-484]
--------
V
D
L
W
Q
D
A
T
A
Q
A
E
L
V
R
S
G
E
I
S
R
T
E
L
L
E
A
T
I
---
A
H
V
Q
A
V
N
---
P
E
I
N
A
V
I
I
P
L
F
E
K
A
R
-
R
E
S
---------
E
L
A
S
G
P
F
A
G
V
P
Y
L
L
K
D
L
T
V
V
S
Q
G
D
I
N
T
S
S
I
K
G
M
K
E
S
G
Y
R
A
D
H
D
A
Y
F
V
Q
R
M
R
A
A
G
F
V
L
L
G
K
T
N
T
P
E
M
G
-------------
N
-----
Q
V
T
T
-----
E
P
E
A
W
G
A
T
R
N
P
W
N
-
L
G
R
S
V
G
G
S
S
G
G
S
G
A
A
V
A
A
A
L
S
P
V
A
H
G
N
D
A
A
G
A
V
R
I
P
A
S
V
C
G
V
V
G
L
K
P
T
R
G
R
I
S
------
P
G
P
L
V
T
D
--
S
-
D
N
V
A
G
A
A
H
E
G
L
F
A
R
S
V
R
D
I
A
A
L
L
D
V
V
S
G
H
R
P
G
D
T
-
F
C
A
P
T
A
S
-
R
---
P
----
Y
A
Q
G
I
-
S
E
N
P
G
S
L
R
V
G
----
V
L
T
H
-
N
P
-
V
GD
F
A
L
D
P
E
C
A
A
A
A
R
G
A
A
A
A
L
A
A
L
G
H
D
V
N
D
A
---
Y
P
E
A
L
-
G
D
RS
F
--------
L
-----
K
D
Y
S
T
I
-----
C
D
V
A
I
A
------------
R
E
I
E
---
R
N
G
E
L
---------------
I
G-----------------------
R
------------
P
------
L
--------------------
T
-----
E
----------------
D
D
V
E
W
T
S
W
-------
E
-
M
V
--------
K
R
A
D
-----
Q
V
T
G
--------
R
A
F
A
-
A
C
V
-
D
E
L
R
Y
--
Y
A
G
-----
K
V
E
-------
R
W
W
E
A-
G
W
D
L
L
I
L
P
T
V
--
T
R
Q
T
P
-
E
I
G
E
L
M
L
A
K
G
TDL
E
G
RQS
A
F
I
S
--
G
S
L
Q
M
L
A
--
F
T
V
P
F
N
V
S
G
Q
P
A
I
S
L
P
I
G
M
S
S
D
G
M
P
I
G
V
Q
I
V
A
A
Y
G
R
E
D
L
L
L
Q
V
A
A
Q
L
E
G
A
L
P
W
V
A
R
R
P
Q
L
L
N
--
3
PsiBlast_PDB
82.31
27%
-71
- C2 -
2DF4
-
GATA_STAAM
A:
[8-473]
--------------
V
E
N
L
L
T
L
I
K
D
K
K
I
K
P
S
D
V
V
K
D
I
Y
---
D
A
I
E
E
T
D
---
P
T
I
K
S
F
L
A
-
L
D
K
E
N
A
I
K
K
A
Q
E
L
D
E
L
Q
A
K
D
Q
M
D
G
K
L
F
G
I
P
M
G
I
K
D
N
I
I
T
-
N
G
L
E
T
T
C
A
S
K
M
L
E
--
G
F
V
P
I
Y
E
S
T
V
M
E
K
L
H
K
E
N
A
V
L
I
G
K
L
N
M
D
E
F
A
-------------
M
-----
G
G
S
T
-----
E
T
S
Y
F
K
K
T
V
N
P
F
D
-
H
K
A
V
P
G
G
S
S
G
G
S
A
A
A
V
A
A
G
L
V
P
L
S
L
G
S
D
T
G
G
S
I
R
Q
P
A
A
Y
C
G
V
V
G
M
K
P
T
Y
G
R
V
S
R-----
F
G
L
V
A
----
F
A
S
---
S
L
D
Q
I
G
P
L
T
R
N
V
K
D
N
A
I
V
L
E
A
I
S
G
A
D
V
N
D
S
-
T
S
A
P
V
D
D
-
V
---
D
----
F
T
S
E
I
-
G
K
D
I
K
G
L
K
V
A
L
P
KE
Y
L
G
E
--------
G
V
A
D
D
V
K
E
A
V
Q
N
A
V
E
T
L
K
S
L
G
A
V
V
E
E
V
S
LP
N
T
K
F
G
I
P
S
--
Y
--------
Y
V
I
A
S
S
E
A
S
S
N
L
-----
S
R
F
--
D
------------
G
I
R
Y
---
G
Y
H
-----------------
S
------------------------
K
------------
E
------
A
--------------------
H
-----
S
L
E
E
L
Y
-----------
K
M
S
R
S
E
G
F
G------
K
-
E
V
--------
K
R
R
I
-----
F
L
G
T
F
A
L
SSGYY
D
A
Y
Y
-
K
K
S
Q
K
V
R
T
L
--
I
K
N
-----
D
F
D
-------
K
V
F
E
--
N
Y
D
V
V
V
G
P
T
A
PT
T
A
F
N
L
-
G
E
E
I
D
D
P
L
T
M
---
Y
A
---
N
D
L
------------
L
T
T
P
V
N
L
A
G
L
P
G
I
S
V
P
C
G
-
Q
S
N
G
R
P
I
G
L
Q
F
I
G
K
P
F
D
E
K
T
L
Y
R
V
A
Y
Q
Y
E
T
Q
Y
N
L
H
D
V
Y
E
K
L
----
8
PsiBlast_PDB
81.99
27%
-70
- C2 -
2F2A
1
GATA_STAAM
A:
[8-473]
--------------
V
E
N
L
L
T
L
I
K
D
K
K
I
K
P
S
D
V
V
K
D
I
Y
---
D
A
I
E
E
T
D
---
P
T
I
K
S
F
L
A
-
L
D
K
E
N
A
I
K
K
A
Q
E
L
D
E
L
Q
A
K
D
Q
M
D
G
K
L
F
G
I
P
M
G
I
K
D
N
I
I
T
-
N
G
L
E
T
T
C
A
S
K
M
L
E
--
G
F
V
P
I
Y
E
S
T
V
M
E
K
L
H
K
E
N
A
V
L
I
G
K
L
N
M
D
E
F
A
-------------
M
-----
G
G
S
T
-----
E
T
S
Y
F
K
K
T
V
N
P
F
D
-
H
K
A
V
P
G
G
S
S
G
G
S
A
A
A
V
A
A
G
L
V
P
L
S
L
G
S
D
T
G
G
S
I
R
Q
P
A
A
Y
C
G
V
V
G
M
K
P
T
Y
G
R
V
S
R-----
F
G
L
V
A
----
F
A
S
---
S
L
D
Q
I
G
P
L
T
R
N
V
K
D
N
A
I
V
L
E
A
I
S
G
A
D
V
N
D
S
-
T
S
A
P
V
D
D
-
V
---
D
----
F
T
S
E
I
-
G
K
D
I
K
G
L
K
V
A
L
P
KE
Y
L
G
E
--------
G
V
A
D
D
V
K
E
A
V
Q
N
A
V
E
T
L
K
S
L
G
A
V
V
E
E
V
S
LP
N
T
K
F
G
I
P
S
--
Y
--------
Y
V
I
A
S
S
E
A
S
S
N
L
-----
S
R
F
--
D
------------
G
I
R
Y
---
G
Y
H
-----------------
S
------------------------
K
------------
E
------
A
--------------------
H
-----
S
L
E
E
L
Y
-----------
K
M
S
R
S
E
G
F
G------
K
-
E
V
--------
K
R
R
I
-----
F
L
G
T
F
A
L
SSGYY
D
A
Y
Y
-
K
K
S
Q
K
V
R
T
L
--
I
K
N
-----
D
F
D
-------
K
V
F
E
--
N
Y
D
V
V
V
G
P
T
A
PT
T
A
F
N
L
-
G
E
E
I
D
D
P
L
T
M
---
Y
A
---
N
D
L
------------
L
T
T
P
V
N
L
A
G
L
P
G
I
S
V
P
C
G
-
Q
S
N
G
R
P
I
G
L
Q
F
I
G
K
P
F
D
E
K
T
L
Y
R
V
A
Y
Q
Y
E
T
Q
Y
N
L
H
D
V
Y
E
K
L
----
7
PsiBlast_PDB
81.88
27%
-71
- C2 -
3IP4
-
GATA_STAAM
A:
[8-473]
--------------
V
E
N
L
L
T
L
I
K
D
K
K
I
K
P
S
D
V
V
K
D
I
Y
---
D
A
I
E
E
T
D
---
P
T
I
K
S
F
L
A
-
L
D
K
E
N
A
I
K
K
A
Q
E
L
D
E
L
Q
A
K
D
Q
M
D
G
K
L
F
G
I
P
M
G
I
K
D
N
I
I
T
-
N
G
L
E
T
T
C
A
S
K
M
L
E
--
G
F
V
P
I
Y
E
S
T
V
M
E
K
L
H
K
E
N
A
V
L
I
G
K
L
N
M
D
E
F
A
-------------
M
-----
G
G
S
T
-----
E
T
S
Y
F
K
K
T
V
N
P
F
D
-
H
K
A
V
P
G
G
S
S
G
G
S
A
A
A
V
A
A
G
L
V
P
L
S
L
G
S
D
T
G
G
S
I
R
Q
P
A
A
Y
C
G
V
V
G
M
K
P
T
Y
G
R
V
S
R-----
F
G
L
V
A
----
F
A
S
---
S
L
D
Q
I
G
P
L
T
R
N
V
K
D
N
A
I
V
L
E
A
I
S
G
A
D
V
N
D
S
-
T
S
A
P
V
D
D
-
V
---
D
----
F
T
S
E
I
-
G
K
D
I
K
G
L
K
V
A
L
P
KE
Y
L
G
E
--------
G
V
A
D
D
V
K
E
A
V
Q
N
A
V
E
T
L
K
S
L
G
A
V
V
E
E
V
S
LP
N
T
K
F
G
I
P
S
--
Y
--------
Y
V
I
A
S
S
E
A
S
S
N
L
-----
S
R
F
--
D
------------
G
I
R
Y
---
G
Y
H
-----------------
S
------------------------
K
------------
E
------
A
--------------------
H
-----
S
L
E
E
L
Y
-----------
K
M
S
R
S
E
G
F
G------
K
-
E
V
--------
K
R
R
I
-----
F
L
G
T
F
A
L
SSGYY
D
A
Y
Y
-
K
K
S
Q
K
V
R
T
L
--
I
K
N
-----
D
F
D
-------
K
V
F
E
--
N
Y
D
V
V
V
G
P
T
A
PT
T
A
F
N
L
-
G
E
E
I
D
D
P
L
T
M
---
Y
A
---
N
D
L
------------
L
T
T
P
V
N
L
A
G
L
P
G
I
S
V
P
C
G
-
Q
S
N
G
R
P
I
G
L
Q
F
I
G
K
P
F
D
E
K
T
L
Y
R
V
A
Y
Q
Y
E
T
Q
Y
N
L
H
D
V
Y
E
K
L
----
5
PsiBlast_PDB
81.57
27%
-70
- C2 -
2G5H
-
GATA_STAAM
A:
[8-473]
--------------
V
E
N
L
L
T
L
I
K
D
K
K
I
K
P
S
D
V
V
K
D
I
Y
---
D
A
I
E
E
T
D
---
P
T
I
K
S
F
L
A
-
L
D
K
E
N
A
I
K
K
A
Q
E
L
D
E
L
Q
A
K
D
Q
M
D
G
K
L
F
G
I
P
M
G
I
K
D
N
I
I
T
-
N
G
L
E
T
T
C
A
S
K
M
L
E
--
G
F
V
P
I
Y
E
S
T
V
M
E
K
L
H
K
E
N
A
V
L
I
G
K
L
N
M
D
E
F
A
-------------
M
-----
G
G
S
T
-----
E
T
S
Y
F
K
K
T
V
N
P
F
D
-
H
K
A
V
P
G
G
S
S
G
G
S
A
A
A
V
A
A
G
L
V
P
L
S
L
G
S
D
T
G
G
S
I
R
Q
P
A
A
Y
C
G
V
V
G
M
K
P
T
Y
G
R
V
S
R-----
F
G
L
V
A
----
F
A
S
---
S
L
D
Q
I
G
P
L
T
R
N
V
K
D
N
A
I
V
L
E
A
I
S
G
A
D
V
N
D
S
-
T
S
A
P
V
D
D
-
V
---
D
----
F
T
S
E
I
-
G
K
D
I
K
G
L
K
V
A
L
P
KE
Y
L
G
E
--------
G
V
A
D
D
V
K
E
A
V
Q
N
A
V
E
T
L
K
S
L
G
A
V
V
E
E
V
S
LP
N
T
K
F
G
I
P
S
--
Y
--------
Y
V
I
A
S
S
E
A
S
S
N
L
-----
S
R
F
--
D
------------
G
I
R
Y
---
G
Y
H
-----------------
S
------------------------
K
------------
E
------
A
--------------------
H
-----
S
L
E
E
L
Y
-----------
K
M
S
R
S
E
G
F
G------
K
-
E
V
--------
K
R
R
I
-----
F
L
G
T
F
A
L
SSGYY
D
A
Y
Y
-
K
K
S
Q
K
V
R
T
L
--
I
K
N
-----
D
F
D
-------
K
V
F
E
--
N
Y
D
V
V
V
G
P
T
A
PT
T
A
F
N
L
-
G
E
E
I
D
D
P
L
T
M
---
Y
A
---
N
D
L
------------
L
T
T
P
V
N
L
A
G
L
P
G
I
S
V
P
C
G
-
Q
S
N
G
R
P
I
G
L
Q
F
I
G
K
P
F
D
E
K
T
L
Y
R
V
A
Y
Q
Y
E
T
Q
Y
N
L
H
D
V
Y
E
K
L
----
14
PsiBlast_PDB
80.98
26%
-72
- C2 -
2GI3
6
GATA_THEMA
A:
[12-471]
-----------------
I
E
E
C
L
K
L
S
E
E
E
R
E
K
L
P
Q
L
S
L
---
E
T
I
K
R
L
D
---
P
H
V
K
A
F
I
S
V
R
--------------
E
N
V
S
V
E
K
K
G
K
F
W
G
I
P
V
A
I
K
D
N
I
L
T
-
L
G
M
R
T
T
C
A
S
R
I
L
E
--
N
Y
E
S
V
F
D
A
T
V
V
K
K
M
K
E
A
G
F
V
V
V
G
K
A
N
L
D
E
F
A
-------------
M
-----
G
S
S
T
-----
E
R
S
A
F
F
P
T
R
N
P
W
D
-
L
E
R
V
P
G
G
S
S
G
G
S
A
A
A
V
S
A
G
M
V
V
A
A
L
G
S
D
T
G
G
S
V
R
Q
P
A
S
L
C
G
V
V
G
Y
K
P
T
Y
G
L
V
S
-------
R
Y
G
L
V
A
--
F
A
S
---
S
L
D
Q
I
G
P
I
T
K
T
V
R
D
A
A
I
L
M
E
I
I
S
G
R
D
E
N
D
A
-
T
T
V
N
R
K
--
V
---
D
----
F
L
S
E
I
-
E
E
G
V
S
G
M
K
F
A
----
V
P
E
E
-
I
Y
E
H
---
D
I
E
E
G
V
S
E
R
F
E
E
A
L
K
L
L
E
R
L
G
A
K
V
E
R
V
---
K
I
P
H
I
K
---------------------
Y
S
V
A
-----
T
Y
Y
V
I
A
P
A
E
---------
A
S
S
N
------------------------------------------------------------------------------------------------------------------------TRNVG
F
G
E
-
E
V
--------
R
R
R
I
-----
M
I
G
T
F
T
L
S
A
A
Y
Y
E
A
Y
F
N
K
A
M
-
K
V
R
R
K
--
I
S
D
-----
E
L
N
-------
E
V
L
S
--
Q
Y
D
A
I
L
T
P
T
S
--
P
V
T
A
F
-
K
I
------------
G
---
E
I
K
D
P
L
T
Y
Y
L
M
D
I
--
F
T
I
P
A
N
L
A
G
L
P
A
I
S
V
P
F
G
F
-
S
N
N
L
P
V
G
V
Q
V
I
G
R
R
F
A
D
G
K
V
F
R
I
A
R
A
I
E
K
N
S
P
Y
N
E
N
G
M
F
P
L
P
E
V
6
PsiBlast_PDB
80.29
27%
-70
- C2 -
2G5I
-
GATA_STAAM
A:
[8-473]
--------------
V
E
N
L
L
T
L
I
K
D
K
K
I
K
P
S
D
V
V
K
D
I
Y
---
D
A
I
E
E
T
D
---
P
T
I
K
S
F
L
A
-
L
D
K
E
N
A
I
K
K
A
Q
E
L
D
E
L
Q
A
K
D
Q
M
D
G
K
L
F
G
I
P
M
G
I
K
D
N
I
I
T
-
N
G
L
E
T
T
C
A
S
K
M
L
E
--
G
F
V
P
I
Y
E
S
T
V
M
E
K
L
H
K
E
N
A
V
L
I
G
K
L
N
M
D
E
F
A
-------------
M
-----
G
G
S
T
-----
E
T
S
Y
F
K
K
T
V
N
P
F
D
-
H
K
A
V
P
G
G
S
S
G
G
S
A
A
A
V
A
A
G
L
V
P
L
S
L
G
S
D
T
G
G
S
I
R
Q
P
A
A
Y
C
G
V
V
G
M
K
P
T
Y
G
R
V
S
R-----
F
G
L
V
A
----
F
A
S
---
S
L
D
Q
I
G
P
L
T
R
N
V
K
D
N
A
I
V
L
E
A
I
S
G
A
D
V
N
D
S
-
T
S
A
P
V
D
D
-
V
---
D
----
F
T
S
E
I
-
G
K
D
I
K
G
L
K
V
A
LPKE
Y
L
G
E
--------
G
V
A
D
D
V
K
E
A
V
Q
N
A
V
E
T
L
K
S
L
G
A
V
V
E
E
V
S
LP
N
T
K
F
G
I
P
S
--
Y
--------
Y
V
I
A
S
S
E
A
S
S
N
L
-----
S
R
F
--
D
------------
G
I
R
Y
---
G
Y
H
-----------------
S
------------------------
K
------------
E
------
A
--------------------
H
-----
S
L
E
E
L
Y
-----------
K
M
S
R
S
E
G
F
G------
K
-
E
V
--------
K
R
R
I
-----
F
L
G
T
F
A
L
SSGYY
D
A
Y
Y
-
K
K
S
Q
K
V
R
T
L
--
I
K
N
-----
D
F
D
-------
K
V
F
E
--
N
Y
D
V
V
V
G
P
T
A
PT
T
A
F
N
L
-
G
E
E
I
D
D
P
L
T
M
---
Y
A
---
N
D
L
------------
L
T
T
P
V
N
L
A
G
L
P
G
I
S
V
P
C
G
-
Q
S
N
G
R
P
I
G
L
Q
F
I
G
K
P
F
D
E
K
T
L
Y
R
V
A
Y
Q
Y
E
T
Q
Y
N
L
H
D
V
Y
E
K
L
----
18
PsiBlast_PDB
79.88
28%
-60
- C2 -
3A1I
1
?
A:
[86-507]
----------------------------------------------------------------------------------
G
V
L
T
G
R
R
V
A
I
K
D
N
V
T
V
-
A
G
V
P
M
M
N
G
S
R
T
V
E
--
G
F
T
P
S
R
D
A
T
V
V
T
R
L
L
A
A
G
A
T
V
A
G
K
A
V
C
E
D
L
C
-------------
F
-----
S
G
S
S
-----
F
T
P
A
S
G
P
V
R
N
P
W
D
-
R
Q
R
E
A
G
G
S
S
G
G
S
A
A
L
V
A
N
G
D
V
D
F
A
I
G
G
D
Q
G
G
A
I
R
I
P
A
A
F
C
G
V
V
G
H
K
P
T
F
G
L
V
P
------
Y
T
G
A
F
P
I
ER
T
I
D
---
H
L
G
---
P
I
T
R
T
V
H
D
A
A
L
M
L
S
V
I
A
G
R
D
G
N
D
P
R
Q
A
D
S
V
E
A
-
G
---
D
----
Y
L
S
T
L
-
D
S
D
V
D
G
L
R
I
G
----
I
V
R
E
-
G
F
G
H
--
A
V
S
Q
P
E
V
D
D
A
V
R
A
A
A
H
S
L
T
E
I
G
C
T
V
E
E
V
---
N
I
---
P
W
H
--
L
H
A
------
F
-----
H
I
W
N
V
I
A
T
D
GG
A
Y
Q
M
L
D
------------
G
N
G
Y
---
G
M
N
-----------------
A
EGLY--------------------
D
------------
P
E
L
M
A
H
F
A
--------------------
S
-----
R
----------------
R
I
Q
H
A
D
A
L
-------
S
-
E
T
V
K
L
V
A
L
T
G
H
H
G
I
T----
T
L
G
G
--------
A
S
Y
G
-
K
A
R
-
N
L
V
P
L
--
A
R
A
-----
A
Y
D
-------
T
A
L
R
--
Q
F
D
V
L
V
M
P
T
-----
L
P
Y
V
A
S
E
L
P
A
K
D
V
D
---
R
A
---
T
F
I
T
--
K
A
L
G
M
I
A
--
N
T
A
P
F
D
V
T
G
H
P
S
L
S
V
P
A
G
L
-
V
N
G
L
P
V
G
M
M
I
T
G
R
H
F
D
D
A
T
V
L
R
V
G
R
A
F
E
K
L
R
G
A
F
---
P
T
P
A
E
--
96
Fugue
79.64
27%
-59
- C2 -
1M22
1
?
A:
[5-494]
------
P
F
P
Y
A
E
T
D
V
A
D
L
Q
A
R
M
T
A
G
E
L
D
S
T
T
L
T
Q
A
Y
L
---
Q
R
I
A
A
L
D
RTG
P
R
L
R
A
V
I
E
L
N
P
--
D
A
L
K
E
A
A
E
R
D
R
E
R
R
D
G
R
L
R
G
P
L
H
G
I
P
L
L
L
K
D
N
I
N
A
-
A
P
M
A
T
S
A
G
S
L
A
L
Q
--
G
F
R
P
-
D
D
A
Y
L
V
R
R
L
R
D
A
G
A
V
V
L
G
K
T
N
L
S
E
W
A
-------------
N
-----
F
R
G
N
DSISG
W
S
A
R
G
G
Q
T
R
N
P
Y
R
-
I
S
H
S
P
C
G
S
S
S
G
S
A
V
A
V
A
A
N
L
A
S
V
A
I
G
T
E
T
D
G
S
I
V
C
P
A
A
I
N
G
V
V
G
L
K
P
T
V
G
L
V
S
------
R
D
G
I
I
P
---
I
S
F
---
S
Q
D
T
A
G
P
M
A
R
S
V
A
D
A
A
A
V
L
T
A
I
A
G
R
D
D
A
D
P
-
A
T
A
T
M
P
G
-
R
---
A
VYDY
T
A
R
L
D
-
P
Q
G
L
R
G
K
R
I
G
----
L
L
Q
T
-
P
L
L
K
-----
Y
R
G
M
P
P
L
I
E
Q
A
A
T
E
L
R
R
A
G
A
V
V
V
P
V
---
E
L
P
-
N
Q
G
A
--
W
--------
A
-----
E
A
E
R
T
L
-----
L
L
Y
E
F
K
------------
A
G
L
E
---
R
Y
F
-----------------
N
T
H
RAPLRS
L
A
D
L
I
A
F
N
Q
A
H
SKQEL
G
------------
L
------
F
--------------------
G
-----
Q
----------------
E
L
L
V
E
A
D
A
-------
T
-
A
G
--------
L
A
D
P
-----
A
Y
I
R
--------
A
R
S
D
-
A
R
R
-
L
A
G
P
E
--
G
I
D
-----
A
A
L
-------
A
A
-
H
--
Q
L
D
A
L
V
A
P
T
T
---
G
V
A
W
-
P
I
R
S
D
--
F
P
G
---
E
-------------------
S
Y
S
A
A
A
V
A
G
Y
P
S
L
T
V
P
M
G
Q
I
-
D
G
L
P
V
G
L
L
F
M
G
T
A
W
S
E
P
K
L
I
E
M
A
Y
A
Y
E
Q
R
T
R
A
---
R
R
P
P
H
F
D
T
16
PsiBlast_PDB
79.62
29%
-56
- C2 -
1M22
1
?
A:
[16-485]
-----------------
L
Q
A
R
M
T
A
G
E
L
D
S
T
T
L
T
Q
A
Y
L
Q
R
I
A
A
L
D
R
T
G
---
P
R
L
R
A
V
I
E
L
N
P
--
D
A
L
K
E
A
A
E
R
D
R
E
R
R
D
G
R
L
R
G
P
L
H
G
I
P
L
L
L
K
D
N
I
N
A
-
A
P
M
A
T
S
A
G
S
L
A
L
Q
--
G
F
R
P
D
-
D
A
Y
L
V
R
R
L
R
D
A
G
A
V
V
L
G
K
T
N
L
S
E
W
A
NFRGNDSISGWSA
R
-----
G
G
Q
T
-----
R
N
P
--------
Y
R
-
I
S
H
S
P
C
G
S
S
S
G
S
A
V
A
V
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---
Q
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---
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----
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---
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A
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L
L
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--------------
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---