@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0211: (2015-12-26 )
MTDVARLLALRSFTELGARQRARALLDAGSFRELLDPFAGVQSPWLERQGIVPQADDGVVVARGLLDGQPAVLAAIEGAFQGGSLGEVSGAKIAGALELAAEDNRNGVPTRALLLLETGGVRLQEANLGLAAIAEIQAAIVDLQRYQPVVAVIAGPVGCFGGMSIAAGLCSYVLVTREARLGLNGPQVIEQEAGIAEYDSRDRPFIWSLTGGEQRFASGLADAYLADDLDEVRTSVLAYFAKGLPARPRCRRAEDYLRRLGDLDTAEQPDAAGVRRLYQGLGQGDAT
Atome Classification :
(20 SA)
----------------------.........10....-------------....20.......-.30....---....---.40.-------..----.-....50-....---....60.....------...70........80........90........100.......110.......120.......130-..------------------------...------------------------------------------....140..-.-..-..150.......160..-..-...170-..-...-.--.180.......190......-.200.......210.-......220.......230.......240-----....----------------....250.......260.......270.......280.....--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------M
T
D
V
A
R
L
L
A
L
R
S
F
T
E
-------------
L
G
A
R
Q
R
A
R
A
L
LD
A
-
G
S
-
F
R
E
L
---
L
D
P
F
---AGVQ-------SP----
W
-
L
E
RQGI-VPQA---DD
G
V
V
V
A
RGLL------DG
Q
P
A
V
L
A
A
I
E
G
AFQGGSLGEVSG
A
K
I
A
G
A
L
E
L
AAEDNRNGVP
T
R
A
L
L
L
L
ETG
G
V
R
L
Q
EANL
G
L
---
A
A
------------------------
I
A
E
------------------------------------------
I
Q
A
A
I
V
D
L
Q
-R-YQ-
P
V
V
A
V
IAG
P
V
G
CFG
G
M
S
-
I
A
-
A
G
L
C
S
Y
-
V
L
-
V
T
R
-E--ARLGLN
G
P
Q
V
I
E
QEAGIAEY-DSRDR
P
F
I
W
S
LTGG
E
-
Q
R
F
A
S
GL
A
D
A
Y
L
A
D
D
L
D
E
V
R
T
S
V
L
A
Y
F
A
------KGLP----------------ARP
R
C
R
R
A
E
D
Y
L
R
R
LGDLDTAEQP
D
A
A
G
V
R
R
L
Y
Q
G
LGQGDAT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
Fugue
81.88
26%
-75
- C5 -
1ON3
5
12S_PROFR
A:
[7-523]
KLAST
M
E
G
R
V
E
Q
L
A
E
Q
R
Q
V
I
E
A
G
G
G
E
R
R
V
E
K
Q
H
S
Q
G
K
-------------
Q
T
A
R
E
R
L
N
N
L
L
D
P
-
H
S
-
F
D
E
V
---
G
A
F
R
---
K
H
R
T
-------
T
L
----
F
-
G
M
D
K
A
V
-
V
P
-----
A
D
G
V
V
T
G
R
G
T
I
------
L
G
R
P
V
H
A
A
S
Q
D
F
T
V
M
G
G
S
A
G
E
T
Q
S
T
K
V
V
E
T
M
E
Q
A
L
L
T
---
G
T
P
--
F
L
F
F
Y
D
S
G
G
A
R
I
Q
E
G
I
D
S
L
---
S
G
------------------------
Y
G
K
------------------------------------------
M
F
F
A
N
V
K
L
S
-
G
-
V
V
-
P
Q
I
A
I
I
A
G
P
C
A
--
G
G
A
S
-
Y
S
-
P
A
L
T
D
F
-
I
I
-
M
T
K
-
K
--
A
H
M
F
I
T
G
P
Q
V
I
K
S
V
T
G
--------
E
D
V
T
A
D
E
L
G
G
A
E
-
A
H
M
A
I
S
G
N
I
H
F
V
A
E
D
D
D
A
A
E
L
I
A
K
K
L
L
S
F
LPQNN
T
E
E
A
----------------
S
F
V
N
P
N
N
D
V
S
P
N
T
E
L
R
D
I
V
P
I
D
G
K
K
G
Y
D
V
R
D
V
I
A
K
I
V
D
W
G
D
Y
L
E
V
KAGYATN
L
V
T
A
F
A
R
V
NG
R
S
V
G
I
V
A
N
Q
PSVMSGCLD
I
N
A
S
D
K
A
A
E
F
V
N
F
C
D
S
F
N
I
P
L
V
Q
L
V
D
V
PGFLPG
V
Q
Q
E
Y
G
G
I
I
R
H
G
A
K
M
L
Y
A
Y
S
E
AT
V
P
K
I
T
V
V
LRKAYG
G
S
Y
L
A
M
CNRDLGAD
A
V
Y
A
W
PS
A
E
I
A
VMG
A
E
G
A
A
N
V
I
F
R
K
E
I
K
A
ADD
P
D
A
M
R
A
E
K
I
E
E
Y
Q
N
A
FNT
P
Y
V
A
A
A
R
GQVD
D
V
I
D
PAD
T
R
R
K
I
A
S
A
L
E
M
Y
A
T
K
R
Q
T
R
PAKKHGNFPC
43
HHSearch
81.23
28%
-82
- C5 -
3IAV
3
?
A:
[35-258]
--------------------------
R
A
V
E
K
Q
H
A
K
G
K
-------------
L
T
A
R
E
R
I
D
L
L
L
D
E
-
G
S
-
F
V
E
L
---
D
E
-
F
---
A
R
H
R
-------
S
T
----
N
-
F
G
-
L
D
A
-
N
R
P
Y
---
G
D
G
V
V
T
G
Y
G
T
V
------
D
G
R
P
V
A
V
F
S
Q
D
F
T
V
F
G
G
A
L
G
E
V
Y
G
Q
K
I
V
K
V
M
D
F
A
L
K
-----
T
G
C
P
V
V
G
I
N
D
S
G
G
A
R
I
Q
E
G
V
A
S
L
---
G
A
------------------------
Y
G
E
------------------------------------------
I
F
R
R
N
T
H
A
S
-
G
-
V
I
-
P
Q
I
S
L
V
V
G
P
--
C
A
G
G
A
V
-
Y
S
-
P
A
I
T
D
F
-
T
V
-
M
V
D
-
Q
T-
S
H
M
F
I
T
G
P
D
V
I
K
T
V
T
G
E
D
-
V
-
G
F
E
E
------
L
G
G
A
R
T
H
N
S
T
S
G
V
A
H
H
M
A
G
D
E
K
D
A
V
E
Y
-
V
K
Q
L
L
S
------
Y
L
P
S
----------------
N
N
L
S
E
P
P
A
F
P
E
E
A
D
L
A
V
T
D
E
D
A
E
L
D
T
I
V
P
D
S
A
N
Q
P
Y
D
M
H
S
V
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
78.46
28%
-76
- C5 -
1VRG
1
?
A:
[46-262]
------------------------------------
K
-------------
L
T
A
W
E
R
L
E
L
L
L
D
P
-
G
T
-
F
V
E
I
----
D
K
F
---
V
E
H
R
-------
N
T
----
Y
-
F
G
L
D
K
V
K
L
P
R
-----
D
G
V
I
T
G
V
G
E
I
------
N
G
R
K
V
A
V
F
S
Q
D
F
T
V
M
G
G
S
L
G
E
M
H
A
K
K
I
V
K
L
L
D
L
A
L
---
K
M
G
I
P
V
--
I
G
I
N
D
S
G
G
A
R
I
Q
E
G
V
D
A
L
---
A
G
------------------------
Y
G
E
------------------------------------------
I
F
L
R
N
T
L
A
S
-
G
-
V
V
-
P
Q
I
T
V
I
A
G
P
--
C
A
G
G
A
V
-
Y
S
-
P
A
L
T
D
F
-
I
V
M
V
D
Q
-
T
--
A
R
M
F
I
T
G
P
N
V
I
K
A
V
T
G
-
E
E
I
-
S
Q
E
D
-------
L
G
G
A
-
M
V
H
N
Q
K
S
G
N
A
H
F
L
A
D
N
D
E
K
A
M
S
L
V
R
T
L
L
------
S
Y
L
P
----------------
S
N
N
A
E
E
P
P
V
E
D
P
D
T
S
L
E
T
P
E
D
I
L
D
I
L
P
D
N
P
N
K
G
Y
D
V
R
D
V
I
K
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
77.03
31%
-84
- C5 -
2F9Y
1
ACCD_ECOLI
B:
[44-265]
--------------------------
E
V
C
P
K
C
D
H
H
M
R
-------------
M
T
A
R
N
R
L
H
S
L
L
D
E
-
G
S
-
L
V
E
L
---
G
S
E
L
E
P
K
D
V
L
K
-------
F
R
DSKK
Y
K----
Q
K
-
E
T
G
E
---
K
D
A
L
V
V
M
K
G
T
L
------
Y
G
M
P
V
V
A
A
A
F
E
F
A
F
M
G
G
S
M
G
S
V
V
G
A
R
F
V
R
A
V
E
Q
A
L
E
-----
D
N
C
P
L
I
C
F
S
A
S
G
G
A
R
M
Q
E
A
L
M
S
L
---
M
Q
------------------------
M
A
K
------------------------------------------
T
S
A
A
L
A
K
M
Q
-
E
R
G
L
-
P
Y
I
S
V
L
T
D
P
--
T
M
G
G
V
S
A
S
F
-
A
M
L
G
D
L
-
N
I
-
A
E
P
-
K
--
A
L
I
G
F
A
G
P
R
V
I
E
Q
T
V
R
E
K
-
L
-
P
P
-------
G
F
Q
R
S
E
-
F
L
I
E
K
G
A
I
D
M
I
V
R
R
P
E
M
R
L
K
L
A
S
I
L
A
K
L
------
M
N
L
P
----------------
A
P
N
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
74.43
22%
-76
- C5 -
3N6R
1
?
B:
[45-305]
----------------------------
I
D
A
Q
H
G
R
G
K
-------------
L
T
A
R
E
R
V
D
L
L
L
D
E
-
G
S
-
F
E
E
F
---
D
-
M
F
---
V
T
H
R
-------
C
T
----
D
-
F
N
-
M
Q
D
-
Q
K
P
A
---
G
D
G
V
V
T
G
W
G
T
I
------
N
G
R
V
V
Y
V
F
S
Q
D
F
T
V
L
G
G
S
V
S
E
T
H
S
K
K
I
C
K
I
M
D
M
A
M
Q
-----
N
G
A
P
V
I
G
I
N
D
S
G
G
A
R
I
Q
E
G
V
D
S
L
---
A
G
------------------------
Y
G
E
------------------------------------------
V
F
Q
R
N
I
M
A
S
-
G
-
V
V
-
P
Q
I
S
M
I
M
G
P
--
C
A
G
G
A
V
-
Y
S
-
P
A
M
T
D
F
-
I
F
-
M
V
K
-
D
S-
S
Y
M
F
V
T
G
P
D
V
V
K
T
V
T
N
E
Q
-
V
-
S
A
E
E
------
L
G
G
A
T
T
H
T
R
K
S
S
V
A
D
A
A
F
E
N
D
V
E
A
L
A
E
-
V
R
R
L
V
D
------
F
L
P
L
NNREKP
P
V
R
P
F
FDDPD
R
I
E
P
S
L
D
T
L
V
P
D
N
P
N
T
P
Y
D
M
K
E
L
I
H
K
L
A
D
E
G
D
F
Y
E
I
Q
E
E
F
A
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
Fugue
73.38
21%
-88
- C5 -
2F9I
1
ACCD_STAAC
B:
[26-285]
---------------PAGI
M
T
K
C
P
K
C
K
K
I
M
Y
T
K
E
L
A
E
N
LNVCFNCDHHIA
L
T
A
Y
K
R
I
E
A
I
S
D
E
-
G
S
-
F
T
E
F
---
D
K
G
M
---
T
S
A
N
PLDFPS
Y
L
E
----
K
-
I
E
K
D
Q
Q
-
K
T
G
L
---
K
E
A
V
V
T
G
T
A
Q
L
------
D
G
M
K
F
G
V
A
V
M
D
S
R
F
R
M
G
S
M
G
S
V
I
G
E
K
I
C
R
I
I
D
Y
C
T
E
N
R
-----
L
P
F
I
L
F
S
A
S
G
G
A
R
M
Q
E
G
I
I
S
L
---
M
Q
------------------------
M
G
K
------------------------------------------
T
S
V
S
L
K
R
H
S
-
D
-
A
G
L
L
Y
I
S
Y
L
T
H
P
T
T
G
-
G
V
S
A
-
S
F
-
A
S
V
G
D
I
-
N
L
-
S
E
P
-
K
--
A
L
I
G
F
A
G
R
R
V
I
E
Q
T
I
N
E
K
L
P
-
D
D
F
Q
T
--------
A
E
-
F
L
L
E
H
G
Q
L
D
K
V
V
--
H
R
N
D
M
R
Q
T
L
S
E
I
L
K
------
I
H
Q
E
----------------
V
T
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
HHSearch
72.63
18%
-86
- C5 -
2X24
1
?
A:
[73-386]
-----------------------------------
Y
P
-------------
K
D
I
L
T
Y
T
E
L
V
L
D
P
Q
G
Q
-
L
V
E
M
---
N
R
-
L
-----------------------------
P
G
G
N
---
E
V
G
M
V
A
F
K
M
T
L
K
T
LEYP
E
G
R
D
I
I
L
I
S
N
D
I
T
F
R
I
G
S
F
G
P
G
E
D
L
L
Y
L
R
A
S
E
L
A
R
A
-----
E
G
I
P
R
V
Y
L
A
A
N
S
G
A
R
I
G
L
A
E
E
I
K
---
H
M
F
Q
V
A
W
VDPEDPHKGIK
Y
L
Y
L
T
P
Q
D
Y
T
R
I
SSLNS
V
H
C
K
H
V
E
E
DG
E
S
R
Y
V
IT
D
I
I
G
KEEGLG
V
E
N
L
R
G
S
G
M
I
A
G
E
T
S
Q
D
Y
-
D
-
E
I
-
V
T
I
S
M
V
S
C
R
--
A
L
G
I
G
A
-
Y
L
-
V
R
L
G
Q
R
-
V
I
-
Q
V
E
-
N
--
S
H
I
I
L
T
G
A
T
A
L
N
K
V
L
G
R
D
V
Y
T
S
N
N
Q
------
L
G
G
V
Q
-
I
M
H
H
N
G
V
S
H
V
T
V
P
D
D
F
E
G
V
C
T
-
I
L
E
W
L
S
------
Y
M
P
K
DNR-------------
S
P
V
P
V
V
T
P
K
D
P
I
D
R
E
I
E
F
Q
P
S
R
--
G
P
Y
D
P
R
W
L
L
A
G
R
P
H
P
T
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
72.59
26%
-79
- C5 -
1X0U
-
?
A:
[31-254]
---------------------------
R
I
Q
F
Q
H
S
K
G
K
-------------
L
T
A
R
E
R
L
A
L
L
F
D
D
-
G
K
-
F
N
E
I
---
M
T
-
F
---
A
T
T
R
-------
A
T
----
E
-
F
G
-
L
D
K
-
Q
R
F
Y
---
G
D
G
V
V
T
G
W
G
K
V
------
D
G
R
T
V
F
A
Y
A
Q
D
F
T
V
L
G
G
S
L
G
E
T
H
A
N
K
I
V
R
A
Y
E
L
A
L
K
-----
V
G
A
P
V
V
G
I
N
D
S
G
G
A
R
I
Q
E
G
A
L
S
L
---
E
G
------------------------
Y
G
A
------------------------------------------
V
F
K
M
N
V
M
A
S
-
G
-
V
I
-
P
Q
I
T
I
M
A
G
P
--
A
A
G
G
A
V
-
Y
S
-
P
A
L
T
D
F
-
I
I
-
M
I
K
-
G
DA
Y
Y
M
F
V
T
G
P
E
I
T
K
V
V
L
G
E
E
-
V
-
S
F
Q
D
------
L
G
G
A
V
V
H
A
T
K
S
G
V
V
H
F
M
V
D
S
E
Q
E
A
I
N
L
-
T
K
R
L
L
S
------
Y
L
P
S
----------------
N
N
M
E
E
P
P
Y
I
D
T
G
D
P
A
D
R
D
A
T
G
V
E
Q
I
V
P
N
D
A
A
K
P
Y
N
M
R
E
I
I
Y
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
71.96
28%
-82
* C5 *
1VRG
1
?
A:
[38-259]
----------------------------
V
E
K
Q
H
R
A
G
K
-------------
L
T
A
W
E
R
L
E
L
L
L
D
P
-
G
T
-
F
V
E
I
---
D
K
-
F
---
V
E
H
R
-------
N
T
----
Y
-
F
G
-
L
D
K
-
V
K
L
P
---
R
D
G
V
I
T
G
V
G
E
I
------
N
G
R
K
V
A
V
F
S
Q
D
F
T
V
M
G
G
S
L
G
E
M
H
A
K
K
I
V
K
L
L
D
L
A
L
K
-----
M
G
I
P
V
I
G
I
N
D
S
G
G
A
R
I
Q
E
G
V
D
A
L
---
A
G
------------------------
Y
G
E
------------------------------------------
I
F
L
R
N
T
L
A
S
-
G
-
V
V
-
P
Q
I
T
V
I
A
G
P
--
C
A
G
G
A
V
-
Y
S
-
P
A
L
T
D
F
-
I
V
-
M
V
D
-
Q
T-
A
R
M
F
I
T
G
P
N
V
I
K
A
V
T
G
E
E
-
I
-
S
Q
E
D
------
L
G
G
A
M
V
H
N
Q
K
S
G
N
A
H
F
L
A
D
N
D
E
K
A
M
S
L
-
V
R
T
L
L
S
------
Y
L
P
S
----------------
N
N
A
E
E
P
P
V
E
D
P
D
T
S
L
E
T
P
E
D
I
L
D
I
L
P
D
N
P
N
K
G
Y
D
V
R
D
V
I
K
R
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
71.93
35%
-96
- C5 -
2F9Y
-
ACCD_ECOLI
B:
[55-235]
--------------------------------------------------
M
T
A
R
N
R
L
H
S
L
L
D
E
-
G
S
-
L
V
E
L
GSE
L
E
P
K
---
D
V
L
K
FRDS---
K
K
----
Y
-
K
-------
Q
K
E
TGE
K
D
A
L
V
V
M
K
G
T
L
------
Y
G
M
P
V
V
A
A
A
F
E
F
A
F
M
G
G
S
M
G
S
V
V
G
A
R
F
V
R
A
V
E
Q
A
L
E
D
N
-----
C
P
L
I
C
F
S
A
S
G
G
A
R
M
Q
E
A
L
M
S
L
---
M
Q
------------------------
M
A
K
------------------------------------------
T
S
A
A
L
A
K
M
Q
E
R
-
G
L
-
P
Y
I
S
V
L
T
D
P
T
--
M
G
G
V
S
-
A
S
F
A
M
L
G
D
L
-
N
I
-
A
E
P
-
K
--
A
L
I
G
F
A
G
P
R
V
I
E
Q
T
V
R
E
K
L
P
-
P
G
F
Q
R
S
E
F
L
I
E
K
G
A
I
-
D
M
I
V
R
R
P
E
M
R
L
K
L
A
S
I
L
A
K
L
M
N
L
P
A
P
N
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
71.83
32%
-94
- C5 -
3IAV
2
?
B:
[45-216]
------------------------------------
K
-------------
L
T
A
R
E
R
I
D
L
L
L
D
E
-
G
S
-
F
V
E
L
----
D
E
F
---
A
R
H
R
-------
S
T
----
N
-
F
G
L
D
A
N
-
R
P
Y
G
---
D
-
G
V
V
T
G
Y
G
T
V
------
D
G
R
P
V
A
V
F
S
Q
D
F
T
V
F
G
G
A
L
G
E
V
Y
G
Q
K
I
V
K
V
M
D
F
A
L
---
K
T
G
C
P
V
--
V
G
I
N
D
S
G
G
A
R
I
Q
E
G
V
A
S
L
---
G
A
------------------------
Y
G
E
------------------------------------------
I
F
R
R
N
T
H
A
S
-
G
-
V
I
-
P
Q
I
S
L
V
V
G
P
--
C
A
G
G
A
V
-
Y
S
-
P
A
I
T
D
F
T
V
M
-
V
D
Q
-
T
--
S
H
M
F
I
T
G
P
D
V
I
K
T
V
T
G
E
D
V
G
-
F
E
E
L
G
G
A
R
T
H
N
S
T
S
G
-
V
A
H
H
M
A
G
D
E
K
D
A
V
E
Y
V
K
Q
L
L
S
Y
L
P
S
N
N
L
------
S
E
P
P
----------------
A
F
P
E
E
A
D
L
A
V
T
D
E
D
A
E
L
D
T
I
V
P
D
S
A
N
Q
P
Y
D
M
H
S
V
I
E
H
V
L
D
D
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
71.40
30%
-75
- C5 -
1ON3
3
12S_PROFR
A:
[35-255]
----------------------------
V
E
K
Q
H
S
Q
G
K
-------------
Q
T
A
R
E
R
L
N
N
L
L
D
P
-
H
S
-
F
D
E
V
---
G
-
A
F
---
R
K
H
R
-------
T
-----
T
-
L
F
G
M
D
K
-
A
V
V
P
---
A
D
G
V
V
T
G
R
G
T
I
------
L
G
R
P
V
H
A
A
S
Q
D
F
T
V
M
G
G
S
A
G
E
T
Q
S
T
K
V
V
E
T
M
E
Q
A
L
L
-----
T
G
T
P
F
L
F
F
Y
D
S
G
G
A
R
I
Q
E
G
I
D
S
L
---
S
G
------------------------
Y
G
K
------------------------------------------
M
F
F
A
N
V
K
L
S
-
G
-
V
V
-
P
Q
I
A
I
I
A
G
P
--
C
A
G
G
A
S
-
Y
S
-
P
A
L
T
D
F
-
I
I
-
M
T
K
-
K
--
A
H
M
F
I
T
G
P
Q
V
I
K
S
V
T
G
E
D
-
V
-
T
A
D
E
------
L
G
G
A
E
A
H
M
A
I
S
G
N
I
H
F
V
A
E
D
D
D
A
A
E
L
I
-
A
K
K
L
L
S
------
F
L
P
Q
----------------
N
N
T
E
E
A
S
F
V
N
P
N
N
D
V
S
P
N
T
E
L
R
D
I
V
P
I
D
G
K
K
G
Y
D
V
R
D
V
I
A
K
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
71.36
21%
-77
- C5 -
3U9R
2
?
B:
[64-324]
---------------------------
A
Q
A
R
H
S
A
R
G
K
-------------
L
L
V
R
E
R
I
N
R
L
L
D
P
-
G
S
P
F
L
E
L
---
S
-
A
L
---
A
A
H
E
-------
V
-----
Y
------
G
-
E
E
V
A
---
A
A
G
I
V
A
G
I
G
R
V
------
E
G
V
E
C
M
I
V
G
N
D
A
T
V
K
G
G
T
Y
Y
P
L
T
V
K
K
H
L
R
A
Q
A
I
A
L
E
-----
N
R
L
P
C
I
Y
L
V
D
S
G
G
A
N
L
P
R
Q
D
E
V
F
PDR
E
H
------------------------
F
G
R
------------------------------------------
I
F
F
N
Q
A
N
M
S
-
A
R
G
I
-
P
Q
I
A
V
V
M
G
S
--
C
T
A
G
G
A
-
Y
V
-
P
A
M
S
D
E
-
T
V
-
M
V
R
E
Q
--
A
T
I
F
L
A
G
P
P
L
V
K
A
A
T
G
E
V
-
V
-
S
A
E
E
------
L
G
G
A
D
V
H
C
K
V
S
G
V
A
D
H
Y
A
E
D
D
D
H
A
L
A
I
-
A
R
R
C
V
A
------
N
L
N
W
RKQGQLQCRAPRAPL-
Y
P
A
E
E
L
Y
G
V
I
P
A
D
S
K
Q
P
Y
D
V
R
E
V
I
A
R
L
V
D
G
S
E
F
D
E
F
K
A
L
F
G
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
71.28
32%
-97
- C5 -
3IB9
2
?
B:
[45-216]
------------------------------------
K
-------------
L
T
A
R
E
R
I
D
L
L
L
D
E
-
G
S
-
F
V
E
L
----
D
E
F
---
A
R
H
R
-------
S
T
----
N
-
F
G
L
D
A
N
-
R
P
Y
G
---
D
-
G
V
V
T
G
Y
G
T
V
------
D
G
R
P
V
A
V
F
S
Q
D
F
T
V
F
G
G
A
L
G
E
V
Y
G
Q
K
I
V
K
V
M
D
F
A
L
---
K
T
G
C
P
V
--
V
G
I
N
D
S
G
G
A
R
I
Q
E
G
V
A
S
L
---
G
A
------------------------
Y
G
E
------------------------------------------
I
F
R
R
N
T
H
A
S
-
G
-
V
I
-
P
Q
I
S
L
V
V
G
P
--
C
A
G
G
A
V
-
Y
S
-
P
A
I
T
D
F
T
V
M
-
V
D
Q
-
T
--
S
H
M
F
I
T
G
P
D
V
I
K
T
V
T
G
E
D
V
G
-
F
E
E
L
G
G
A
R
T
H
N
S
T
S
G
-
V
A
H
H
M
A
G
D
E
K
D
A
V
E
Y
V
K
Q
L
L
S
Y
L
P
S
N
N
L
------
S
E
P
P
----------------
A
F
P
E
E
A
D
L
A
V
T
D
E
D
A
E
L
D
T
I
V
P
D
S
A
N
Q
P
Y
D
M
H
S
V
I
E
H
V
L
D
D
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
71.24
33%
-91
- C5 -
1ON9
1
12S_PROFR
F:
[46-213]
----------------------------------------------------
A
R
E
R
L
N
N
L
L
D
P
-
H
S
-
F
D
E
V
---
G
A
F
R
---
K
H
R
T
-------
T
L
----
F
-
G
M
D
K
A
V
-
V
P
A
-----
D
G
V
V
T
G
R
G
T
I
------
L
G
R
P
V
H
A
A
S
Q
D
F
T
V
M
G
G
S
A
G
E
T
Q
S
T
K
V
V
E
T
M
E
Q
A
L
---
L
T
G
T
P
F
--
L
F
F
Y
D
S
G
G
A
R
I
Q
E
G
I
D
S
L
---
S
G
------------------------
Y
G
K
------------------------------------------
M
F
F
A
N
V
K
L
S
-
G
-
V
V
-
P
Q
I
A
I
I
A
G
P
--
C
A
G
G
A
S
-
Y
S
-
P
A
L
T
D
F
-
I
I
-
M
T
K
-
K
--
A
H
M
F
I
T
G
P
Q
V
I
K
S
V
T
G
E
D
V
T
-
A
D
E
L
G
G
A
E
A
H
M
A
I
S
G
-
N
I
H
F
V
A
E
D
D
D
A
A
E
L
I
A
K
K
L
L
S
F
L
P
Q
N
N
T
------
E
E
A
S
----------------
F
V
N
P
N
N
D
V
S
P
N
T
E
L
R
D
I
V
P
I
D
G
K
K
G
Y
D
V
R
D
V
I
A
K
I
V
D
W
G
D
Y
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
70.94
32%
-92
- C5 -
1XNY
2
?
B:
[45-216]
------------------------------------
K
-------------
L
T
A
R
E
R
I
D
L
L
L
D
E
-
G
S
-
F
V
E
L
----
D
E
F
---
A
R
H
R
-------
S
T
----
N
-
F
G
L
D
A
N
-
R
P
Y
G
---
D
-
G
V
V
T
G
Y
G
T
V
------
D
G
R
P
V
A
V
F
S
Q
D
F
T
V
F
G
G
A
L
G
E
V
Y
G
Q
K
I
V
K
V
M
D
F
A
L
---
K
T
G
C
P
V
--
V
G
I
N
D
S
G
G
A
R
I
Q
E
G
V
A
S
L
---
G
A
------------------------
Y
G
E
------------------------------------------
I
F
R
R
N
T
H
A
S
-
G
-
V
I
-
P
Q
I
S
L
V
V
G
P
--
C
A
G
G
A
V
-
Y
S
-
P
A
I
T
D
F
T
V
M
-
V
D
Q
-
T
--
S
H
M
F
I
T
G
P
D
V
I
K
T
V
T
G
E
D
V
G
-
F
E
E
L
G
G
A
R
T
H
N
S
T
S
G
-
V
A
H
H
M
A
G
D
E
K
D
A
V
E
Y
V
K
Q
L
L
S
Y
L
P
S
N
N
L
------
S
E
P
P
----------------
A
F
P
E
E
A
D
L
A
V
T
D
E
D
A
E
L
D
T
I
V
P
D
S
A
N
Q
P
Y
D
M
H
S
V
I
E
H
V
L
D
D
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
70.47
32%
-91
- C5 -
1XO6
-
?
A:
[45-216]
------------------------------------
K
-------------
L
T
A
R
E
R
I
D
L
L
L
D
E
-
G
S
-
F
V
E
L
----
D
E
F
---
A
R
H
R
-------
S
T
----
N
-
F
G
L
D
A
N
-
R
P
Y
G
---
D
-
G
V
V
T
G
Y
G
T
V
------
D
G
R
P
V
A
V
F
S
Q
D
F
T
V
F
G
G
A
L
G
E
V
Y
G
Q
K
I
V
K
V
M
D
F
A
L
---
K
T
G
C
P
V
--
V
G
I
N
D
S
G
G
A
R
I
Q
E
G
V
A
S
L
---
G
A
------------------------
Y
G
E
------------------------------------------
I
F
R
R
N
T
H
A
S
-
G
-
V
I
-
P
Q
I
S
L
V
V
G
P
--
C
A
G
G
A
V
-
Y
S
-
P
A
I
T
D
F
T
V
M
-
V
D
Q
-
T
--
S
H
M
F
I
T
G
P
D
V
I
K
T
V
T
G
E
D
V
G
-
F
E
E
L
G
G
A
R
T
H
N
S
T
S
G
-
V
A
H
H
M
A
G
D
E
K
D
A
V
E
Y
V
K
Q
L
L
S
Y
L
P
S
N
N
L
------
S
E
P
P
----------------
A
F
P
E
E
A
D
L
A
V
T
D
E
D
A
E
L
D
T
I
V
P
D
S
A
N
Q
P
Y
D
M
H
S
V
I
E
H
V
L
D
D
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
70.46
32%
-90
- C5 -
3IAV
3
?
A:
[45-216]
------------------------------------
K
-------------
L
T
A
R
E
R
I
D
L
L
L
D
E
-
G
S
-
F
V
E
L
----
D
E
F
---
A
R
H
R
-------
S
T
----
N
-
F
G
L
D
A
N
-
R
P
Y
G
---
D
-
G
V
V
T
G
Y
G
T
V
------
D
G
R
P
V
A
V
F
S
Q
D
F
T
V
F
G
G
A
L
G
E
V
Y
G
Q
K
I
V
K
V
M
D
F
A
L
---
K
T
G
C
P
V
--
V
G
I
N
D
S
G
G
A
R
I
Q
E
G
V
A
S
L
---
G
A
------------------------
Y
G
E
------------------------------------------
I
F
R
R
N
T
H
A
S
-
G
-
V
I
-
P
Q
I
S
L
V
V
G
P
--
C
A
G
G
A
V
-
Y
S
-
P
A
I
T
D
F
T
V
M
-
V
D
Q
-
T
--
S
H
M
F
I
T
G
P
D
V
I
K
T
V
T
G
E
D
V
G
-
F
E
E
L
G
G
A
R
T
H
N
S
T
S
G
-
V
A
H
H
M
A
G
D
E
K
D
A
V
E
Y
V
K
Q
L
L
S
Y
L
P
S
N
N
L
------
S
E
P
P
----------------
A
F
P
E
E
A
D
L
A
V
T
D
E
D
A
E
L
D
T
I
V
P
D
S
A
N
Q
P
Y
D
M
H
S
V
I
E
H
V
L
D
D
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
70.14
33%
-95
- C5 -
1ON9
1
12S_PROFR
D:
[46-213]
----------------------------------------------------
A
R
E
R
L
N
N
L
L
D
P
-
H
S
-
F
D
E
V
---
G
A
F
R
---
K
H
R
T
-------
T
L
----
F
-
G
M
D
K
A
V
-
V
P
A
-----
D
G
V
V
T
G
R
G
T
I
------
L
G
R
P
V
H
A
A
S
Q
D
F
T
V
M
G
G
S
A
G
E
T
Q
S
T
K
V
V
E
T
M
E
Q
A
L
---
L
T
G
T
P
F
--
L
F
F
Y
D
S
G
G
A
R
I
Q
E
G
I
D
S
L
---
S
G
------------------------
Y
G
K
------------------------------------------
M
F
F
A
N
V
K
L
S
-
G
-
V
V
-
P
Q
I
A
I
I
A
G
P
--
C
A
G
G
A
S
-
Y
S
-
P
A
L
T
D
F
-
I
I
-
M
T
K
-
K
--
A
H
M
F
I
T
G
P
Q
V
I
K
S
V
T
G
E
D
V
T
-
A
D
E
L
G
G
A
E
A
H
M
A
I
S
G
-
N
I
H
F
V
A
E
D
D
D
A
A
E
L
I
A
K
K
L
L
S
F
L
P
Q
N
N
T
------
E
E
A
S
----------------
F
V
N
P
N
N
D
V
S
P
N
T
E
L
R
D
I
V
P
I
D
G
K
K
G
Y
D
V
R
D
V
I
A
K
I
V
D
W
G
D
Y
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
70.11
33%
-94
- C5 -
1ON9
1
12S_PROFR
B:
[46-213]
----------------------------------------------------
A
R
E
R
L
N
N
L
L
D
P
-
H
S
-
F
D
E
V
---
G
A
F
R
---
K
H
R
T
-------
T
L
----
F
-
G
M
D
K
A
V
-
V
P
A
-----
D
G
V
V
T
G
R
G
T
I
------
L
G
R
P
V
H
A
A
S
Q
D
F
T
V
M
G
G
S
A
G
E
T
Q
S
T
K
V
V
E
T
M
E
Q
A
L
---
L
T
G
T
P
F
--
L
F
F
Y
D
S
G
G
A
R
I
Q
E
G
I
D
S
L
---
S
G
------------------------
Y
G
K
------------------------------------------
M
F
F
A
N
V
K
L
S
-
G
-
V
V
-
P
Q
I
A
I
I
A
G
P
--
C
A
G
G
A
S
-
Y
S
-
P
A
L
T
D
F
-
I
I
-
M
T
K
-
K
--
A
H
M
F
I
T
G
P
Q
V
I
K
S
V
T
G
E
D
V
T
-
A
D
E
L
G
G
A
E
A
H
M
A
I
S
G
-
N
I
H
F
V
A
E
D
D
D
A
A
E
L
I
A
K
K
L
L
S
F
L
P
Q
N
N
T
------
E
E
A
S
----------------
F
V
N
P
N
N
D
V
S
P
N
T
E
L
R
D
I
V
P
I
D
G
K
K
G
Y
D
V
R
D
V
I
A
K
I
V
D
W
G
D
Y
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------