@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0223: (2015-12-27 )
MSASIHGIIGYTITPFAADGGLDLPALGRSIERLIDGGVHAIAPLGSTGEGAYLSDPEWDEVVDFTLKTVAHRVPTIVSVSDLTTAKTVRRAQFAESLGAEAVMVLPISYWKLNEAEVFQHYRAVGEAIGVPVMLYNNPGTSGIDMSVELILRIVREVDNVTMVKESTGDIQRMHKLRLLGEGRVPFYNGCNPLALEAFVAGAKGWCSAAPNLIPTLNGQLYQAVLDGDLEKARALFYRQLPLLDFILRRGLPTTIKAGLGLSGLEVGAPRLPVQALDTEGCRYLQGLLEELR
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150....-...160.......170....-.-.-.180......-.190.......200.......210.......220.......230.......240.......250.....---..260.......270.......-----280.......290.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSA
S
I
H
G
I
I
G
Y
T
ITPFAADGGLD
L
P
A
L
G
R
S
I
E
R
L
IDGG
V
H
A
IAPLGSTGEGAYLSDP
E
W
D
E
V
V
D
F
T
L
K
T
V
A
HRVP
T
I
V
S
VSDL
T
T
A
K
T
V
R
R
A
Q
F
A
E
S
LGA
E
A
V
M
V
L
P
I
S
Y
W
KL
N
E
A
E
V
F
Q
H
Y
R
A
V
G
E
AIG
V
P
V
M
L
YNNPGTSG
I
D
M
S
V
E
L
I
L
R
I
V
R
-EVDN
V
T
M
V
KESTG
D
I
Q
R
M
H
K
-
L
-
R
-LLGEGRVPFY-NGC
N
P
L
A
L
E
A
F
V
AGAK
G
W
C
SAAPNLIPTLN
G
Q
L
Y
Q
A
V
LDG
D
L
E
K
A
R
A
L
F
Y
R
QL
P
L
L
D
F
I
L
RRGL
P
T
T
I
K
---AGLGLSGLEVGAPRLPVQALDT-----E
G
C
R
Y
L
Q
G
L
L
E
ELR
1
PsiBlast_PDB
99.53
97%
-123
- C6 -
3NA8
2
?
A:
[23-313]
--
A
S
I
H
G
I
I
G
Y
T
I
T
P
F
A
A
D
G
G
L
D
L
P
A
L
G
R
S
I
E
R
L
I
D
G
G
V
H
A
I
A
P
L
G
S
T
G
E
G
A
Y
L
S
D
P
E
W
D
E
V
V
D
F
T
L
K
T
V
A
H
R
V
P
T
I
V
S
V
S
D
L
T
T
A
K
T
V
R
R
A
Q
F
A
E
S
L
G
A
E
A
V
M
V
L
P
I
S
Y
W
K
L
N
E
A
E
V
F
Q
H
Y
R
A
V
G
E
A
I
G
V
P
V
M
L
Y
N
N
P
G
T
S
G
I
D
M
S
V
E
L
I
L
R
I
V
R
-
E
V
D
N
V
T
M
V
K
E
S
T
G
D
I
Q
R
M
H
K
-
L
-
R
-
L
L
G
E
G
R
V
P
F
Y
-
N
G
C
N
P
L
A
L
E
A
F
V
A
G
A
K
G
W
C
S
A
A
P
N
L
I
P
T
L
N
G
Q
L
Y
Q
A
V
L
D
G
D
L
E
K
A
R
A
L
F
Y
R
Q
L
P
L
L
D
F
I
L
R
R
G
L
P
T
T
I
K
---
A
G
L
G
L
S
G
L
E
V
G
A
P
R
L
P
V
Q
A
L
D
T
-----
E
G
C
R
Y
L
Q
G
L
L
E
E
L
R
72
HHSearch
98.51
99%
-120
- C6 -
3NA8
2
?
A:
[23-313]
--
A
S
I
H
G
I
I
G
Y
T
I
T
P
F
A
A
D
G
G
L
D
L
P
A
L
G
R
S
I
E
R
L
I
D
G
G
V
H
A
I
A
P
L
G
S
T
G
E
G
A
Y
L
S
D
P
E
W
D
E
V
V
D
F
T
L
K
T
V
A
H
R
V
P
T
I
V
S
V
S
D
L
T
T
A
K
T
V
R
R
A
Q
F
A
E
S
L
G
A
E
A
V
M
V
L
P
I
S
Y
W
K
L
N
E
A
E
V
F
Q
H
Y
R
A
V
G
E
A
I
G
V
P
V
M
L
Y
N
N
P
G
T
S
G
I
D
M
S
V
E
L
I
L
R
-
I
V
R
E
V
D
N
V
T
M
V
K
E
S
T
G
D
I
Q
R
M
H
K
-
L
-
R
-
L
L
G
E
G
R
V
P
F
Y
-
N
G
C
N
P
L
A
L
E
A
F
V
A
G
A
K
G
W
C
S
A
A
P
N
L
I
P
T
L
N
G
Q
L
Y
Q
A
V
L
D
G
D
L
E
K
A
R
A
L
F
Y
R
Q
L
P
L
L
D
F
I
L
R
R
G
L
P
T
T
I
K
---
A
G
L
G
L
S
G
L
E
V
G
A
P
R
L
P
V
Q
A
L
D
T
-----
E
G
C
R
Y
L
Q
G
L
L
E
E
L
R
4
PsiBlast_PDB
73.04
28%
-115
- C6 -
2YXG
-
DAPA_METJA
A:
[4-286]
------
G
V
Y
P
A
I
I
T
P
F
K
-
N
K
E
V
D
F
D
G
L
E
E
N
I
N
F
L
I
E
N
G
V
S
G
I
V
A
V
G
T
T
G
E
S
P
T
L
S
H
E
E
H
K
K
V
I
E
K
V
V
D
V
V
N
G
R
V
Q
V
I
A
G
A
G
S
N
C
T
E
E
A
I
E
L
S
V
F
A
E
D
V
G
A
D
A
V
L
S
I
T
P
Y
Y
N
K
P
T
Q
E
G
L
R
K
H
F
G
K
V
A
E
S
I
N
L
P
I
V
L
Y
N
V
P
S
R
T
A
V
N
L
E
P
K
T
V
K
L
L
A
E
-
E
Y
S
N
I
S
A
V
K
E
A
N
P
N
L
S
Q
V
S
E
-----
L
I
H
D
A
K
I
T
V
L
-
S
G
N
D
E
L
T
L
P
I
I
A
L
G
G
K
G
V
I
S
V
V
A
N
I
V
P
K
E
F
V
E
M
V
N
Y
A
L
E
G
D
F
E
K
A
R
E
I
H
Y
K
L
F
P
L
M
K
A
M
F
I
E
T
N
P
I
P
V
K
---
T
A
L
N
M
M
G
R
P
A
G
E
L
R
L
P
L
C
E
M
S
E
-----
E
H
K
K
I
L
E
N
V
L
K
D
L
G
16
PsiBlast_PDB
72.06
29%
-114
- C6 -
2EHH
1
DAPA_AQUAE
A:
[2-287]
----
F
Q
G
S
I
V
A
L
I
T
P
F
K
-
E
G
E
V
D
Y
E
A
L
G
N
L
I
E
F
H
V
D
N
G
T
D
A
I
L
V
C
G
T
T
G
E
S
P
T
L
T
F
E
E
H
E
K
V
I
E
F
A
V
K
R
A
A
G
R
I
K
V
I
A
G
T
G
G
N
A
T
H
E
A
V
H
L
T
A
H
A
K
E
V
G
A
D
G
A
L
V
V
V
P
Y
Y
N
K
P
T
Q
R
G
L
Y
E
H
F
K
T
V
A
Q
E
V
D
I
P
I
I
I
Y
N
I
P
S
R
T
C
V
E
I
S
V
D
T
M
F
K
L
A
S
-
E
C
E
N
I
V
A
S
K
E
S
T
P
N
M
D
R
I
S
E
-
I
V
K
-
R
L
G
E
S
-
F
S
V
L
-
S
G
D
D
S
L
T
L
P
M
M
A
L
G
A
K
G
V
I
S
V
A
N
N
V
M
P
R
E
V
K
E
L
I
R
A
A
L
E
G
D
F
R
R
A
R
E
I
H
Y
Y
L
H
D
L
F
K
V
L
F
I
E
T
N
P
I
P
V
K
---
T
A
C
W
M
L
G
M
C
E
K
E
F
R
L
P
L
T
E
M
S
P
-----
E
N
E
N
K
L
R
E
V
L
K
K
Y
N
83
HHSearch
71.32
28%
-112
- C6 -
2YXG
-
DAPA_METJA
A:
[1-286]
---
M
F
K
G
V
Y
P
A
I
I
T
P
F
K
N
-
K
E
V
D
F
D
G
L
E
E
N
I
N
F
L
I
E
N
G
V
S
G
I
V
A
V
G
T
T
G
E
S
P
T
L
S
H
E
E
H
K
K
V
I
E
K
V
V
D
V
V
N
G
R
V
Q
V
I
A
G
A
G
S
N
C
T
E
E
A
I
E
L
S
V
F
A
E
D
V
G
A
D
A
V
L
S
I
T
P
Y
Y
N
K
P
T
Q
E
G
L
R
K
H
F
G
K
V
A
E
S
I
N
L
P
I
V
L
Y
N
V
P
S
R
T
A
V
N
L
E
P
K
T
V
K
L
-
L
A
E
E
Y
S
N
I
S
A
V
K
E
A
N
P
N
L
S
Q
V
S
E
-
L
-
I
-
H
--
D
A
K
I
T
V
L
-
S
G
N
D
E
L
T
L
P
I
I
A
L
G
G
K
G
V
I
S
V
V
A
N
I
V
P
K
E
F
V
E
M
V
N
Y
A
L
E
G
D
F
E
K
A
R
E
I
H
Y
K
L
F
P
L
M
K
A
M
F
I
E
T
N
P
I
P
V
K
---
T
A
L
N
M
M
G
R
P
A
G
E
L
R
L
P
L
C
E
M
S
E
-----
E
H
K
K
I
L
E
N
V
L
K
D
L
G
66
HHSearch
70.45
30%
-104
* C6 *
3QZE
2
DAPA_PSEAE
A:
[23-310]
---
M
I
A
G
S
M
V
A
L
V
T
P
F
D
A
Q
G
R
L
D
W
D
S
L
A
K
L
V
D
F
H
L
Q
E
G
T
N
A
I
V
A
V
G
T
T
G
E
S
A
T
L
D
V
E
E
H
I
Q
V
I
R
R
V
V
D
Q
V
K
G
R
I
P
V
I
A
G
T
G
A
N
S
T
R
E
A
V
A
L
T
E
A
A
K
S
G
G
A
D
A
C
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
M
Y
Q
H
F
R
H
I
A
E
A
V
A
I
P
Q
I
L
Y
N
V
P
G
R
T
S
C
D
M
L
P
E
T
V
E
R
-
L
S
-
K
V
P
N
I
I
G
I
K
E
A
T
G
D
L
Q
R
A
K
E
-
V
-
I
-
E
R
V
G
K
D
F
L
V
Y
-
S
G
D
D
A
T
A
V
E
L
M
L
L
G
G
K
G
N
I
S
V
T
A
N
V
A
P
R
A
M
S
D
L
C
A
A
A
M
R
G
D
A
A
A
A
R
A
I
N
D
R
L
M
P
L
H
K
A
L
F
I
E
S
N
P
I
P
V
K
---
W
A
L
H
E
M
G
L
I
P
E
G
I
R
L
P
L
T
W
L
S
P
-----
R
C
H
E
P
L
R
Q
A
M
R
Q
T
G
21
PsiBlast_CBE
69.68
31%
-107
- C6 -
3SI9
2
DAPA_BARHE
D:
[23-314]
----
L
K
G
A
V
T
A
L
I
T
P
F
D
D
N
G
A
I
D
E
K
A
F
C
N
F
V
E
W
Q
I
T
Q
G
I
N
G
V
S
P
V
G
T
T
G
E
S
P
T
L
T
H
E
E
H
K
R
I
I
E
L
C
V
E
Q
V
A
K
R
V
P
V
V
A
G
A
G
S
N
S
T
S
E
A
V
E
L
A
K
H
A
E
K
A
G
A
D
A
V
L
V
V
T
P
Y
Y
N
R
P
N
Q
R
G
L
Y
T
H
F
S
S
I
A
K
A
I
S
I
P
I
I
I
Y
N
I
P
S
R
S
V
I
D
M
A
V
E
T
M
R
D
L
C
R
-
D
F
K
N
I
I
G
V
K
D
A
T
G
K
I
E
R
A
S
E
-
Q
-
R
E
K
C
G
K
D
F
V
Q
L
S
G
D
D
C
T
A
L
G
F
N
A
H
--
G
G
V
G
C
I
S
V
S
S
N
V
A
P
K
L
C
A
Q
L
H
A
A
C
L
C
S
D
Y
K
T
A
L
K
L
N
D
L
L
M
P
L
N
R
A
V
F
I
E
P
S
P
A
G
I
K
YAA
A
K
L
G
L
C
G
T
I
V
R
S
P
I
V
P
L
S
--
D
T
TKKII
D
E
A
L
Y
H
A
G
L
L
K
---
23
PsiBlast_CBE
69.53
31%
-107
- C6 -
3SI9
2
DAPA_BARHE
B:
[23-313]
----
L
K
G
A
V
T
A
L
I
T
P
F
D
D
N
G
A
I
D
E
K
A
F
C
N
F
V
E
W
Q
I
T
Q
G
I
N
G
V
S
P
V
G
T
T
G
E
S
P
T
L
T
H
E
E
H
K
R
I
I
E
L
C
V
E
Q
V
A
K
R
V
P
V
V
A
G
A
G
S
N
S
T
S
E
A
V
E
L
A
K
H
A
E
K
A
G
A
D
A
V
L
V
V
T
P
Y
Y
N
R
P
N
Q
R
G
L
Y
T
H
F
S
S
I
A
K
A
I
S
I
P
I
I
I
Y
N
I
P
S
R
S
V
I
D
M
A
V
E
T
M
R
D
L
C
R
-
D
F
K
N
I
I
G
V
K
D
A
T
G
K
I
E
R
A
S
E
-
Q
-
R
E
K
C
G
K
D
F
V
Q
L
S
G
D
D
C
T
A
L
G
F
N
A
H
--
G
G
V
G
C
I
S
V
S
S
N
V
A
P
K
L
C
A
Q
L
H
A
A
C
L
C
S
D
Y
K
T
A
L
K
L
N
D
L
L
M
P
L
N
R
A
V
F
I
E
P
S
P
A
G
I
K
YAA
A
K
L
G
L
C
G
T
I
V
R
S
P
I
V
P
L
S
--
D
T
TKKII
D
E
A
L
Y
H
A
G
L
L
----
22
PsiBlast_CBE
69.34
31%
-106
- C6 -
3SI9
3
DAPA_BARHE
C:
[23-313]
----
L
K
G
A
V
T
A
L
I
T
P
F
D
D
N
G
A
I
D
E
K
A
F
C
N
F
V
E
W
Q
I
T
Q
G
I
N
G
V
S
P
V
G
T
T
G
E
S
P
T
L
T
H
E
E
H
K
R
I
I
E
L
C
V
E
Q
V
A
K
R
V
P
V
V
A
G
A
G
S
N
S
T
S
E
A
V
E
L
A
K
H
A
E
K
A
G
A
D
A
V
L
V
V
T
P
Y
Y
N
R
P
N
Q
R
G
L
Y
T
H
F
S
S
I
A
K
A
I
S
I
P
I
I
I
Y
N
I
P
S
R
S
V
I
D
M
A
V
E
T
M
R
D
L
C
R
-
D
F
K
N
I
I
G
V
K
D
A
T
G
K
I
E
R
A
S
E
-
Q
-
R
E
K
C
G
K
D
F
V
Q
L
S
G
D
D
C
T
A
L
G
F
N
A
H
--
G
G
V
G
C
I
S
V
S
S
N
V
A
P
K
L
C
A
Q
L
H
A
A
C
L
C
S
D
Y
K
T
A
L
K
L
N
D
L
L
M
P
L
N
R
A
V
F
I
E
P
S
P
A
G
I
K
YAA
A
K
L
G
L
C
G
T
I
V
R
S
P
I
V
P
L
S
--
D
T
TKKII
D
E
A
L
Y
H
A
G
L
L
----
24
PsiBlast_CBE
68.97
31%
-105
- C6 -
3SI9
3
DAPA_BARHE
A:
[23-314]
----
L
K
G
A
V
T
A
L
I
T
P
F
D
D
N
G
A
I
D
E
K
A
F
C
N
F
V
E
W
Q
I
T
Q
G
I
N
G
V
S
P
V
G
T
T
G
E
S
P
T
L
T
H
E
E
H
K
R
I
I
E
L
C
V
E
Q
V
A
K
R
V
P
V
V
A
G
A
G
S
N
S
T
S
E
A
V
E
L
A
K
H
A
E
K
A
G
A
D
A
V
L
V
V
T
P
Y
Y
N
R
P
N
Q
R
G
L
Y
T
H
F
S
S
I
A
K
A
I
S
I
P
I
I
I
Y
N
I
P
S
R
S
V
I
D
M
A
V
E
T
M
R
D
L
C
R
-
D
F
K
N
I
I
G
V
K
D
A
T
G
K
I
E
R
A
S
E
-
Q
-
R
E
K
C
G
K
D
F
V
Q
L
S
G
D
D
C
T
A
L
G
F
N
A
H
--
G
G
V
G
C
I
S
V
S
S
N
V
A
P
K
L
C
A
Q
L
H
A
A
C
L
C
S
D
Y
K
T
A
L
K
L
N
D
L
L
M
P
L
N
R
A
V
F
I
E
P
S
P
A
G
I
K
Y
A
A
A
K
L
G
L
C
G
T
I
V
R
S
P
I
V
P
L
S
--
D
T
T
K
K
I
I
D
E
A
L
Y
H
A
G
L
L
K
---
36
PsiBlast_CBE
68.94
32%
-106
- C6 -
3QZE
2
DAPA_PSEAE
A:
[24-295]
----
I
A
G
S
M
V
A
L
V
T
P
F
D
A
Q
G
R
L
D
W
D
S
L
A
K
L
V
D
F
H
L
Q
E
G
T
N
A
I
V
A
V
G
T
T
G
E
S
A
T
L
D
V
E
E
H
I
Q
V
I
R
R
V
V
D
Q
V
K
G
R
I
P
V
I
A
G
T
G
A
N
S
T
R
E
A
V
A
L
T
E
A
A
K
S
G
G
A
D
A
C
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
M
Y
Q
H
F
R
H
I
A
E
A
V
A
I
P
Q
I
L
Y
N
V
P
G
R
T
S
C
D
M
L
P
E
T
V
E
R
L
S
K
--
V
P
N
I
I
G
I
K
E
A
T
G
D
L
Q
R
A
K
E
V
I
-
E
-
R
V
G
K
D
F
L
-
V
Y
-
S
G
D
D
A
T
A
V
E
L
M
L
L
G
G
K
G
N
I
S
V
T
A
N
V
A
P
R
A
M
S
D
L
C
A
A
A
M
R
G
D
A
A
A
A
R
A
I
N
D
R
L
M
P
L
H
K
A
L
F
I
E
S
N
P
I
P
V
K
---
W
A
L
H
E
M
G
L
I
P
E
G
I
R
L
P
L
T
W
L
S
P
-----
R
C
H
E
P
L
R
Q
A
M
R
Q
T
G
78
HHSearch
68.81
28%
-109
- C6 -
2EHH
1
DAPA_AQUAE
A:
[1-288]
---
M
F
Q
G
S
I
V
A
L
I
T
P
F
K
E
-
G
E
V
D
Y
E
A
L
G
N
L
I
E
F
H
V
D
N
G
T
D
A
I
L
V
C
G
T
T
G
E
S
P
T
L
T
F
E
E
H
E
K
V
I
E
F
A
V
K
R
A
A
G
R
I
K
V
I
A
G
T
G
G
N
A
T
H
E
A
V
H
L
T
A
H
A
K
E
V
G
A
D
G
A
L
V
V
V
P
Y
Y
N
K
P
T
Q
R
G
L
Y
E
H
F
K
T
V
A
Q
E
V
D
I
P
I
I
I
Y
N
I
P
S
R
T
C
V
E
I
S
V
D
T
M
F
K
-
L
A
S
E
C
E
N
I
V
A
S
K
E
S
T
P
N
M
D
R
I
S
E
-
I
-
V
-
K
R
L
G
E
S
F
S
V
L
-
S
G
D
D
S
L
T
L
P
M
M
A
L
G
A
K
G
V
I
S
V
A
N
N
V
M
P
R
E
V
K
E
L
I
R
A
A
L
E
G
D
F
R
R
A
R
E
I
H
Y
Y
L
H
D
L
F
K
V
L
F
I
E
T
N
P
I
P
V
K
---
T
A
C
W
M
L
G
M
C
E
K
E
F
R
L
P
L
T
E
M
S
P
-----
E
N
E
N
K
L
R
E
V
L
K
K
Y
N
34
PsiBlast_CBE
68.74
32%
-105
- C6 -
3QZE
2
DAPA_PSEAE
C:
[24-295]
----
I
A
G
S
M
V
A
L
V
T
P
F
D
A
Q
G
R
L
D
W
D
S
L
A
K
L
V
D
F
H
L
Q
E
G
T
N
A
I
V
A
V
G
T
T
G
E
S
A
T
L
D
V
E
E
H
I
Q
V
I
R
R
V
V
D
Q
V
K
G
R
I
P
V
I
A
G
T
G
A
N
S
T
R
E
A
V
A
L
T
E
A
A
K
S
G
G
A
D
A
C
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
M
Y
Q
H
F
R
H
I
A
E
A
V
A
I
P
Q
I
L
Y
N
V
P
G
R
T
S
C
D
M
L
P
E
T
V
E
R
L
S
K
--
V
P
N
I
I
G
I
K
E
A
T
G
D
L
Q
R
A
K
E
V
I
-
E
-
R
V
G
K
D
F
L
-
V
Y
-
S
G
D
D
A
T
A
V
E
L
M
L
L
G
G
K
G
N
I
S
V
T
A
N
V
A
P
R
A
M
S
D
L
C
A
A
A
M
R
G
D
A
A
A
A
R
A
I
N
D
R
L
M
P
L
H
K
A
L
F
I
E
S
N
P
I
P
V
K
---
W
A
L
H
E
M
G
L
I
P
E
G
I
R
L
P
L
T
W
L
S
P
-----
R
C
H
E
P
L
R
Q
A
M
R
Q
T
G
35
PsiBlast_CBE
68.73
32%
-106
- C6 -
3QZE
2
DAPA_PSEAE
B:
[24-295]
----
I
A
G
S
M
V
A
L
V
T
P
F
D
A
Q
G
R
L
D
W
D
S
L
A
K
L
V
D
F
H
L
Q
E
G
T
N
A
I
V
A
V
G
T
T
G
E
S
A
T
L
D
V
E
E
H
I
Q
V
I
R
R
V
V
D
Q
V
K
G
R
I
P
V
I
A
G
T
G
A
N
S
T
R
E
A
V
A
L
T
E
A
A
K
S
G
G
A
D
A
C
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
M
Y
Q
H
F
R
H
I
A
E
A
V
A
I
P
Q
I
L
Y
N
V
P
G
R
T
S
C
D
M
L
P
E
T
V
E
R
L
S
K
--
V
P
N
I
I
G
I
K
E
A
T
G
D
L
Q
R
A
K
E
V
I
-
E
-
R
V
G
K
D
F
L
-
V
Y
-
S
G
D
D
A
T
A
V
E
L
M
L
L
G
G
K
G
N
I
S
V
T
A
N
V
A
P
R
A
M
S
D
L
C
A
A
A
M
R
G
D
A
A
A
A
R
A
I
N
D
R
L
M
P
L
H
K
A
L
F
I
E
S
N
P
I
P
V
K
---
W
A
L
H
E
M
G
L
I
P
E
G
I
R
L
P
L
T
W
L
S
P
-----
R
C
H
E
P
L
R
Q
A
M
R
Q
T
G
43
PsiBlast_CBE
68.24
32%
-107
- C6 -
3NOE
4
DAPA_PSEAE
B:
[2-273]
----
I
A
G
S
M
V
A
L
V
T
P
F
D
A
Q
G
R
L
D
W
D
S
L
A
K
L
V
D
F
H
L
Q
D
G
T
N
A
I
V
A
V
G
T
T
G
E
S
A
T
L
D
V
E
E
H
I
Q
V
V
R
R
V
V
D
Q
V
K
G
R
I
P
V
I
A
G
T
G
A
N
S
T
R
E
A
V
A
L
T
E
A
A
K
S
G
G
A
D
A
C
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
M
Y
Q
H
F
R
H
I
A
E
A
V
A
I
P
Q
I
L
Y
N
V
P
G
R
T
S
C
D
M
L
P
E
T
V
E
R
L
S
K
--
V
P
N
I
I
G
I
K
E
A
T
G
D
L
Q
R
A
K
E
V
I
-
E
-
R
V
G
K
D
F
L
-
V
Y
-
S
G
D
D
A
T
A
V
E
L
M
L
L
G
G
K
G
N
I
S
V
T
A
N
V
A
P
R
A
M
S
D
L
C
A
A
A
M
R
G
D
A
A
A
A
R
A
I
N
D
R
L
M
P
L
H
K
A
L
F
I
E
S
N
P
I
P
V
K
---
W
A
L
H
E
M
G
L
I
P
E
G
I
R
L
P
L
T
W
L
S
P
-----
H
C
H
D
P
L
R
Q
A
M
R
Q
T
G
33
PsiBlast_CBE
68.13
32%
-106
- C6 -
3QZE
2
DAPA_PSEAE
D:
[24-295]
----
I
A
G
S
M
V
A
L
V
T
P
F
D
A
Q
G
R
L
D
W
D
S
L
A
K
L
V
D
F
H
L
Q
E
G
T
N
A
I
V
A
V
G
T
T
G
E
S
A
T
L
D
V
E
E
H
I
Q
V
I
R
R
V
V
D
Q
V
K
G
R
I
P
V
I
A
G
T
G
A
N
S
T
R
E
A
V
A
L
T
E
A
A
K
S
G
G
A
D
A
C
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
M
Y
Q
H
F
R
H
I
A
E
A
V
A
I
P
Q
I
L
Y
N
V
P
G
R
T
S
C
D
M
L
P
E
T
V
E
R
L
S
K
--
V
P
N
I
I
G
I
K
E
A
T
G
D
L
Q
R
A
K
E
V
I
-
E
-
R
V
G
K
D
F
L
-
V
Y
-
S
G
D
D
A
T
A
V
E
L
M
L
L
G
G
K
G
N
I
S
V
T
A
N
V
A
P
R
A
M
S
D
L
C
A
A
A
M
R
G
D
A
A
A
A
R
A
I
N
D
R
L
M
P
L
H
K
A
L
F
I
E
S
N
P
I
P
V
K
---
W
A
L
H
E
M
G
L
I
P
E
G
I
R
L
P
L
T
W
L
S
P
-----
R
C
H
E
P
L
R
Q
A
M
R
Q
T
G
39
PsiBlast_CBE
67.82
32%
-103
- C6 -
3PUO
3
DAPA_PSEAE
B:
[2-273]
----
I
A
G
S
M
V
A
L
V
T
P
F
D
A
Q
G
R
L
D
W
D
S
L
A
K
L
V
D
F
H
L
Q
D
G
T
N
A
I
V
A
V
G
T
T
G
E
S
A
T
L
D
V
E
E
H
I
Q
V
V
R
R
V
V
D
Q
V
K
G
R
I
P
V
I
A
G
T
G
A
N
S
T
R
E
A
V
A
L
T
E
A
A
K
S
G
G
A
D
A
C
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
M
Y
Q
H
F
R
H
I
A
E
A
V
A
I
P
Q
I
L
Y
N
V
P
G
R
T
S
C
D
M
L
P
E
T
V
E
R
L
S
K
--
V
P
N
I
I
G
I
K
E
A
T
G
D
L
Q
R
A
K
E
V
I
-
E
-
R
V
G
K
D
F
L
-
V
Y
-
S
G
D
D
A
T
A
V
E
L
M
L
L
G
G
K
G
N
I
S
V
T
A
N
V
A
P
R
A
M
S
D
L
C
A
A
A
M
R
G
D
A
A
A
A
R
A
I
N
D
R
L
M
P
L
H
K
A
L
F
I
E
S
N
P
I
P
V
K
---
W
A
L
H
E
M
G
L
I
P
E
G
I
R
L
P
L
T
W
L
S
P
-----
H
C
H
D
P
L
R
Q
A
M
R
Q
T
G
37
PsiBlast_CBE
67.75
32%
-103
- C6 -
3S8H
1
DAPA_PSEAE
B:
[2-273]
----
I
A
G
S
M
V
A
L
V
T
P
F
D
A
Q
G
R
L
D
W
D
S
L
A
K
L
V
D
F
H
L
Q
D
G
T
N
A
I
V
A
V
G
T
T
G
E
S
A
T
L
D
V
E
E
H
I
Q
V
V
R
R
V
V
D
Q
V
K
G
R
I
P
V
I
A
G
T
G
A
N
S
T
R
E
A
V
A
L
T
E
A
A
K
S
G
G
A
D
A
C
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
M
Y
Q
H
F
R
H
I
A
E
A
V
A
I
P
Q
I
L
Y
N
V
P
G
R
T
S
C
D
M
L
P
E
T
V
E
R
L
S
K
--
V
P
N
I
I
G
I
K
E
A
T
G
D
L
Q
R
A
K
E
V
I
-
E
-
R
V
G
K
D
F
L
-
V
Y
-
S
G
D
D
A
T
A
V
E
L
M
L
L
G
G
K
G
N
I
S
V
T
A
N
V
A
P
R
A
M
S
D
L
C
A
A
A
M
R
G
D
A
A
A
A
R
A
I
N
D
R
L
M
P
L
H
K
A
L
F
I
E
S
N
P
I
P
V
K
---
W
A
L
H
E
M
G
L
I
P
E
G
I
R
L
P
L
T
W
L
S
P
-----
H
C
H
D
P
L
R
Q
A
M
R
Q
T
G
79
HHSearch
67.70
30%
-105
- C6 -
2VC6
-
DAPA_RHIML
A:
[1-288]
---
M
F
E
G
S
I
T
A
L
V
T
P
F
A
D
-
D
R
I
D
E
V
A
L
H
D
L
V
E
W
Q
I
E
E
G
S
F
G
L
V
P
C
G
T
T
G
E
S
P
T
L
S
K
S
E
H
E
Q
V
V
E
I
T
I
K
T
A
N
G
R
V
P
V
I
A
G
A
G
S
N
S
T
A
E
A
I
A
F
V
R
H
A
Q
N
A
G
A
D
G
V
L
I
V
S
P
Y
Y
N
K
P
T
Q
E
G
I
Y
Q
H
F
K
A
I
D
A
A
S
T
I
P
I
I
V
Y
N
I
P
G
R
S
A
I
E
I
H
V
E
T
L
A
R
-
I
F
E
D
C
P
N
V
K
G
V
-
D
A
T
G
N
L
L
R
P
S
L
-
E
-
R
-
M
A
C
G
E
D
F
N
L
L
-
T
G
E
D
G
T
A
L
G
Y
M
A
H
G
G
H
G
C
I
S
V
T
A
N
V
A
P
A
L
C
A
D
F
Q
Q
A
C
L
N
G
D
F
A
A
A
L
K
L
Q
D
R
L
M
P
L
H
R
A
L
F
L
E
T
N
P
A
G
A
K
---
Y
A
L
Q
R
L
G
R
M
R
G
D
L
R
L
P
L
V
T
I
S
P
-----
S
F
Q
E
E
I
D
D
A
M
R
H
A
G
64
HHSearch
67.45
30%
-107
- C6 -
1XKY
2
?
A:
[11-299]
--
I
D
F
G
T
I
A
T
A
M
V
T
P
F
D
I
N
G
N
I
D
F
A
K
T
T
K
L
V
N
Y
L
I
D
N
G
T
T
A
I
V
V
G
G
T
T
G
E
S
P
T
L
T
S
E
E
K
V
A
L
Y
R
H
V
V
S
V
V
D
K
R
V
P
V
I
A
G
T
G
S
N
N
T
H
A
S
I
D
L
T
K
K
A
T
E
V
G
V
D
A
V
M
L
V
A
P
Y
Y
N
K
P
S
Q
E
G
M
Y
Q
H
F
K
A
I
A
E
S
T
P
L
P
V
M
L
Y
N
V
P
G
R
S
I
V
Q
I
S
V
D
T
V
V
R
-
L
S
-
E
I
E
N
I
V
A
I
K
D
A
G
G
D
V
L
T
M
T
E
-
I
-
I
-
E
K
T
A
D
D
F
A
V
Y
-
S
G
D
D
G
L
T
L
P
A
M
A
V
G
A
K
G
I
V
S
V
A
S
H
V
I
G
N
E
M
Q
E
M
I
A
A
F
Q
A
G
E
F
K
K
A
Q
K
L
H
Q
L
L
V
R
V
T
D
S
L
F
M
A
P
S
P
T
P
V
K
---
T
A
L
Q
M
V
G
L
D
V
G
S
V
R
L
P
L
L
P
L
T
E
-----
E
E
R
V
T
L
Q
S
V
M
Q
S
I
P