@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0228: (2015-12-27 )
MSREVFICDAVRTPIGRFGGSLSAVRADDLAAVPLKALVERNPGVDWSALDEVFLGCANQAGEDNRNVARMALLLAGLPESVPGVTLNRLCASGMDAIGTAFRAIACGEMELAIAGGVESMSRAPYVMGKADSAFGRGQKIEDTTIGWRFVNPLMKEQYGIDPMPQTADNVADDYRVSRADQDAFALRSQQRAGRAQEAGFFAEEIVPVTIRGRKGDTLVEHDEHPRPDTTLEALARLKPVNGPEKTVTAGNASGVNDGAAALVLASAEAVEKHGLTPRARVLGMASAGVAPRIMGIGPVPAVRKLLRRLDLAIDAFDVIELNEAFASQGLACLRELGVADDSEKVNPNGGAIALGHPLGMSGARLVLTALHQLEKSGGRRGLATMCVGVGQGLALAIERV
Atome Classification :
(20 SA)
.........10......-.-.20........30........40........50........60........70........80........90........100.......110.......120.......130....--...-140-......---..150......-----.160....--------------.--..170.......180.......190.......200.......210.....-.-.-220.......230.......240-------------------.-----------.....-...250.......260.......270.......280.......290.......300.......310.......320.......330.......340-.......350.......360.......370.......380.......390.......400
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSR
E
V
F
I
C
D
A
V
R
T
P
I
G
R-F-GGSLSAVRADDL
A
A
V
P
L
K
A
L
V
ERNPGV
D
W
S
A
L
D
E
V
F
L
GCANQAGEDN
R
N
V
A
R
M
A
L
L
L
AGLPESVP
G
V
T
L
N
R
L
C
AS
G
M
D
A
I
G
T
A
F
R
A
IACG
E
M
E
L
A
I
AGG
V
E
S
MSRA
P
Y
V
MGKADSAFG--RGQ-K-I-EDTT
I
G
---
W
R
F
V
N
P
L
M
K
E
Q-----YGIDPMPQ--------------
T
--
A
D
NV
A
D
D
YRVSRAD
Q
D
A
F
A
L
R
S
Q
Q
RAGR
A
Q
E
AGF
F
A
E
E
I
V
P
V
T
I
RGRKGD-T-L-VEHDEHPRPD
T
T
L
E
A
L
A
RLKP---------------------V-----------NGPE
K
-
T
VTAGNASGVNDGA
A
A
L
V
LA
S
A
E
A
V
E
K
HGL
T
P
R
A
R
V
L
G
MASAGVA
P
R
I
MGIG
P
V
P
A
V
R
K
L
L
R
R
L
D
L
AID
A
F
D
V
I
E
L
N
E
A
F
A
S
Q
G
L
A
C
L
R
E
LGVADD-SEKVNPNG
G
A
I
A
LGHPLGMS
G
A
R
L
V
L
T
A
L
H
Q
L
E
K
SGGRR
G
L
A
T
M
C
V
GVGQG
L
A
L
A
I
ERV
66
PsiBlast_CBE
93.01
42%
-78
- C4 -
4B3H
2
Y0859_MYCTU
C:
[2-403]
-
S
E
E
A
F
I
Y
E
A
I
R
T
P
R
G
K
Q
K
-
N
G
S
L
H
E
V
K
P
L
S
L
V
V
G
L
I
D
E
L
R
K
R
H
P
D
L
D
E
N
L
I
S
D
V
I
L
G
C
V
S
P
V
G
D
Q
G
G
D
I
A
R
A
A
V
L
A
S
G
M
P
V
T
S
G
G
V
Q
L
N
R
F
C
A
S
G
L
E
A
V
N
T
A
A
Q
K
V
R
S
G
W
D
D
L
V
L
A
G
G
V
E
S
M
S
R
V
P
--
M
G
S
D
G
G
A
M
G
----------------------
L
D
P
--
A
T
N
-----
Y
D
V
M
F
V
P
Q
--------------
S
I
G
A
D
L
I
A
T
I
E
G
F
S
R
E
D
V
D
A
Y
A
L
R
S
Q
Q
K
A
A
E
A
W
S
G
G
Y
F
A
K
S
V
V
P
V
--
R
D
Q
N
G
L
-
L
-
I
-
L
D
H
D
E
H
M
R
P
D
T
T
K
E
G
L
A
K
L
K
P
AAALGG
F
D
D
V
A
L
Q
K
Y
HW----
V
-----------
E
K
I
N
H
-
V
H
T
G
G
N
S
S
G
I
V
D
G
A
A
L
V
M
I
G
S
A
A
A
G
K
L
Q
G
L
T
P
R
A
R
I
V
A
T
A
T
S
G
A
D
P
V
I
M
L
T
G
P
T
P
A
T
R
K
V
L
D
R
A
G
L
T
V
D
D
I
D
L
F
E
L
N
E
A
F
A
S
V
V
L
K
F
Q
K
D
L
N
I
P
D
---
E
K
L
N
V
N
G
G
A
I
A
M
G
H
P
L
G
A
T
G
A
M
I
L
G
T
M
V
D
E
L
E
R
R
N
A
R
R
A
L
I
T
L
C
I
G
G
G
M
G
V
A
T
I
I
E
R
V
3
PsiBlast_PDB
92.85
45%
-79
- C4 -
4N45
-
?
A:
[2-391]
--
K
E
V
V
I
A
S
A
V
R
T
A
I
G
S
-
Y
-
G
K
S
L
K
D
V
P
A
V
D
L
G
A
T
A
I
K
E
A
V
K
K
-
A
G
I
K
P
E
D
V
N
E
V
I
L
G
N
V
L
Q
A
G
L
-
G
Q
N
P
A
R
Q
A
S
F
K
A
G
L
P
V
E
I
P
A
M
T
I
N
K
V
C
G
S
G
L
R
T
V
S
L
A
A
Q
I
I
K
A
G
D
A
D
V
I
I
A
G
G
M
E
N
M
S
R
A
P
Y
L
A
N
N
A
R
W
G
Y
R
--
M
G
N
A
K
-
F
-
V
D
E
M
I
T
---
D
G
L
W
D
A
F
N
D
Y
H
-----
M
G
I
-------------------
T
--
A
E
N
I
A
E
R
W
N
I
S
R
E
E
Q
D
E
F
A
L
A
S
Q
K
K
A
E
E
A
I
K
S
G
Q
F
K
D
E
I
V
P
V
V
I
K
G
R
K
G
E
-
T
-
V
-
V
D
T
D
E
H
P
R
F
G
S
T
I
E
G
L
A
K
L
K
P
---------------------
A
-----------
F
K
K
D
G
-
T
V
T
A
G
N
A
S
G
L
N
D
C
A
A
V
L
V
I
M
S
A
E
K
A
K
E
L
G
V
K
P
L
A
K
I
V
S
Y
G
S
A
G
V
D
P
A
I
M
G
Y
G
P
F
Y
A
T
K
A
A
I
E
K
A
G
W
T
V
D
E
L
D
L
I
E
S
N
E
A
F
A
A
Q
S
L
A
V
A
K
D
L
K
F
--
D
-
M
N
K
V
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
V
H
A
M
Q
K
R
D
A
K
K
G
L
A
T
L
S
I
G
G
G
Q
G
T
A
I
L
L
E
K
C
62
PsiBlast_CBE
92.84
42%
-78
- C4 -
4B3J
3
Y0859_MYCTU
C:
[2-403]
-
S
E
E
A
F
I
Y
E
A
I
R
T
P
R
G
K
Q
K
-
N
G
S
L
H
E
V
K
P
L
S
L
V
V
G
L
I
D
E
L
R
K
R
H
P
D
L
D
E
N
L
I
S
D
V
I
L
G
C
V
S
P
V
G
D
Q
G
G
D
I
A
R
A
A
V
L
A
S
G
M
P
V
T
S
G
G
V
Q
L
N
R
F
C
A
S
G
L
E
A
V
N
T
A
A
Q
K
V
R
S
G
W
D
D
L
V
L
A
G
G
V
E
S
M
S
R
V
P
--
M
G
S
D
G
G
A
M
G
----------------------
L
D
P
--
A
T
N
-----
Y
D
V
M
F
V
P
Q
--------------
S
I
G
A
D
L
I
A
T
I
E
G
F
S
R
E
D
V
D
A
Y
A
L
R
S
Q
Q
K
A
A
E
A
W
S
G
G
Y
F
A
K
S
V
V
P
V
--
R
D
Q
N
G
L
-
L
-
I
-
L
D
H
D
E
H
M
R
P
D
T
T
K
E
G
L
A
K
L
K
P
AFEGLAALGG
F
D
D
V
A
L
Q
K
Y
HW
V
-----------
E
K
I
N
H
-
V
H
T
G
G
N
S
S
G
I
V
D
G
A
A
L
V
M
I
G
S
A
A
A
G
K
L
Q
G
L
T
P
R
A
R
I
V
A
T
A
T
S
G
A
D
P
V
I
M
L
T
G
P
T
P
A
T
R
K
V
L
D
R
A
G
L
T
V
D
D
I
D
L
F
E
L
N
E
A
F
A
S
V
V
L
K
F
Q
K
D
L
N
I
P
D
---
E
K
L
N
V
N
G
G
A
I
A
M
G
H
P
L
G
A
T
G
A
M
I
L
G
T
M
V
D
E
L
E
R
R
N
A
R
R
A
L
I
T
L
C
I
G
G
G
M
G
V
A
T
I
I
E
R
V
65
PsiBlast_CBE
92.60
42%
-79
- C4 -
4B3H
7
Y0859_MYCTU
D:
[1-403]
M
S
E
E
A
F
I
Y
E
A
I
R
T
P
R
G
K
Q
K
-
N
G
S
L
H
E
V
K
P
L
S
L
V
V
G
L
I
D
E
L
R
K
R
H
P
D
L
D
E
N
L
I
S
D
V
I
L
G
C
V
S
P
V
G
D
Q
G
G
D
I
A
R
A
A
V
L
A
S
G
M
P
V
T
S
G
G
V
Q
L
N
R
F
C
A
S
G
L
E
A
V
N
T
A
A
Q
K
V
R
S
G
W
D
D
L
V
L
A
G
G
V
E
S
M
S
R
V
P
--
M
G
S
D
G
G
A
M
G
----------------------
L
D
P
--
A
T
N
-----
Y
D
V
M
F
V
P
Q
--------------
S
I
G
A
D
L
I
A
T
I
E
G
F
S
R
E
D
V
D
A
Y
A
L
R
S
Q
Q
K
A
A
E
A
W
S
G
G
Y
F
A
K
S
V
V
P
V
--
R
D
Q
N
G
L
-
L
-
I
-
L
D
H
D
E
H
M
R
P
D
T
T
K
E
G
L
A
K
L
K
P
AFLAALGG
F
D
D
V
A
L
Q
K
Y
HW--
V
-----------
E
K
I
N
H
-
V
H
T
G
G
N
S
S
G
I
V
D
G
A
A
L
V
M
I
G
S
A
A
A
G
K
L
Q
G
L
T
P
R
A
R
I
V
A
T
A
T
S
G
A
D
P
V
I
M
L
T
G
P
T
P
A
T
R
K
V
L
D
R
A
G
L
T
V
D
D
I
D
L
F
E
L
N
E
A
F
A
S
V
V
L
K
F
Q
K
D
L
N
I
P
D
---
E
K
L
N
V
N
G
G
A
I
A
M
G
H
P
L
G
A
T
G
A
M
I
L
G
T
M
V
D
E
L
E
R
R
N
A
R
R
A
L
I
T
L
C
I
G
G
G
M
G
V
A
T
I
I
E
R
V
64
PsiBlast_CBE
92.45
42%
-77
- C4 -
4B3I
1
Y0859_MYCTU
C:
[2-403]
-
S
E
E
A
F
I
Y
E
A
I
R
T
P
R
G
K
Q
K
-
N
G
S
L
H
E
V
K
P
L
S
L
V
V
G
L
I
D
E
L
R
K
R
H
P
D
L
D
E
N
L
I
S
D
V
I
L
G
C
V
S
P
V
G
D
Q
G
G
D
I
A
R
A
A
V
L
A
S
G
M
P
V
T
S
G
G
V
Q
L
N
R
F
C
A
S
G
L
E
A
V
N
T
A
A
Q
K
V
R
S
G
W
D
D
L
V
L
A
G
G
V
E
S
M
S
R
V
P
--
M
G
S
D
G
G
A
M
G
----------------------
L
D
P
--
A
T
N
-----
Y
D
V
M
F
V
P
Q
--------------
S
I
G
A
D
L
I
A
T
I
E
G
F
S
R
E
D
V
D
A
Y
A
L
R
S
Q
Q
K
A
A
E
A
W
S
G
G
Y
F
A
K
S
V
V
P
V
--
R
D
Q
N
G
L
-
L
-
I
-
L
D
H
D
E
H
M
R
P
D
T
T
K
E
G
L
A
K
L
K
P
AFEGLAALGG
F
D
D
V
A
L
Q
K
Y
HW
V
-----------
E
K
I
N
H
-
V
H
T
G
G
N
S
S
G
I
V
D
G
A
A
L
V
M
I
G
S
A
A
A
G
K
L
Q
G
L
T
P
R
A
R
I
V
A
T
A
T
S
G
A
D
P
V
I
M
L
T
G
P
T
P
A
T
R
K
V
L
D
R
A
G
L
T
V
D
D
I
D
L
F
E
L
N
E
A
F
A
S
V
V
L
K
F
Q
K
D
L
N
I
P
D
---
E
K
L
N
V
N
G
G
A
I
A
M
G
H
P
L
G
A
T
G
A
M
I
L
G
T
M
V
D
E
L
E
R
R
N
A
R
R
A
L
I
T
L
C
I
G
G
G
M
G
V
A
T
I
I
E
R
V
1
PsiBlast_PDB
92.39
55%
-85
- C4 -
1ULQ
-
?
A:
[3-398]
---
E
A
W
I
V
E
A
V
R
T
P
I
G
K
-
H
-
G
G
A
L
A
S
V
R
P
D
D
L
L
A
H
A
L
S
V
L
V
D
R
S
-
G
V
P
K
E
E
V
E
D
V
Y
A
G
C
A
N
Q
A
G
E
D
N
R
N
V
A
R
M
A
L
L
L
A
G
F
P
V
E
V
A
G
C
T
V
N
R
L
C
G
S
G
L
E
A
V
A
Q
A
A
R
A
I
W
A
G
E
G
K
V
Y
I
G
S
G
V
E
S
M
S
R
A
P
Y
A
V
P
K
P
E
R
G
F
P
--
T
G
N
-
L
-
V
M
Y
D
T
T
L
G
---
W
R
F
V
N
P
K
M
Q
A
L
-----
Y
G
T
E
S
M
G
E
--------------
T
--
A
E
N
L
A
E
M
Y
G
I
R
R
E
E
Q
D
R
F
A
L
L
S
H
Q
K
A
V
R
A
W
E
E
G
R
F
Q
D
E
V
V
P
V
P
V
K
R
G
K
E
E
-
I
-
L
-
V
E
Q
D
E
G
P
R
R
D
T
S
L
E
K
L
A
A
L
R
P
---------------------
V
-----------
F
R
E
G
G
-
T
V
T
A
G
N
S
S
P
L
N
D
G
A
A
A
V
L
L
V
S
D
D
Y
A
K
A
H
G
L
R
P
L
A
R
V
R
A
I
A
V
A
G
V
P
P
R
I
M
G
I
G
P
V
P
A
T
R
K
A
L
E
R
A
G
L
S
F
S
D
L
G
L
I
E
L
N
E
A
F
A
A
Q
A
L
A
V
L
R
E
W
S
L
S
M
E
-
D
Q
R
L
N
P
N
G
G
A
I
A
L
G
H
P
L
G
A
S
G
A
R
I
L
T
T
L
V
H
E
M
R
R
R
K
V
Q
F
G
L
A
T
M
C
I
G
V
G
Q
G
I
A
V
V
V
E
G
M
104
HHSearch
92.31
55%
-85
- C4 -
1ULQ
-
?
A:
[3-399]
---
E
A
W
I
V
E
A
V
R
T
P
I
G
K
-
H
-
G
G
A
L
A
S
V
R
P
D
D
L
L
A
H
A
L
S
V
L
V
D
R
S
-
G
V
P
K
E
E
V
E
D
V
Y
A
G
C
A
N
Q
A
G
E
D
N
R
N
V
A
R
M
A
L
L
L
A
G
F
P
V
E
V
A
G
C
T
V
N
R
L
C
G
S
G
L
E
A
V
A
Q
A
A
R
A
I
W
A
G
E
G
K
V
Y
I
G
S
G
V
E
S
M
S
R
A
P
Y
A
V
P
K
P
E
R
G
F
P
T
G
N
L
V
-
M
-
Y
-
D
T
-
T
L
G
---
W
R
F
V
N
P
K
M
Q
A
L
-----
Y
G
T
E
S
M
G
E
--------------
T
--
A
E
N
L
A
E
M
Y
G
I
R
R
E
E
Q
D
R
F
A
L
L
S
H
Q
K
A
V
R
A
W
E
E
G
R
F
Q
D
E
V
V
P
V
P
V
K
R
G
K
E
E
-
I
-
L
-
V
E
Q
D
E
G
P
R
R
D
T
S
L
E
K
L
A
A
L
R
P
---------------------
V
-----------
F
R
E
G
G
-
T
V
T
A
G
N
S
S
P
L
N
D
G
A
A
A
V
L
L
V
S
D
D
Y
A
K
A
H
G
L
R
P
L
A
R
V
R
A
I
A
V
A
G
V
P
P
R
I
M
G
I
G
P
V
P
A
T
R
K
A
L
E
R
A
G
L
S
F
S
D
L
G
L
I
E
L
N
E
A
F
A
A
Q
A
L
A
V
L
R
E
W
S
L
S
M
E
-
D
Q
R
L
N
P
N
G
G
A
I
A
L
G
H
P
L
G
A
S
G
A
R
I
L
T
T
L
V
H
E
M
R
R
R
K
V
Q
F
G
L
A
T
M
C
I
G
V
G
Q
G
I
A
V
V
V
E
G
M
28
PsiBlast_CBE
92.23
45%
-83
- C4 -
4O99
1
THIL_CUPNH
C:
[2-391]
---
D
V
V
I
V
S
A
A
R
T
A
V
G
K
-
F
-
G
G
S
L
A
K
I
P
A
P
E
L
G
A
V
V
I
K
A
A
L
E
R
-
A
G
V
K
P
E
Q
V
S
E
V
I
M
G
Q
V
L
T
A
G
S
-
G
Q
N
P
A
R
Q
A
A
I
K
A
G
L
P
A
M
V
P
A
M
T
I
N
K
V
C
G
S
G
L
K
A
V
M
L
A
A
N
A
I
M
A
G
D
A
E
I
V
V
A
G
G
Q
E
N
M
S
A
A
P
H
V
L
P
G
S
R
D
G
F
R
--
M
G
D
A
K
-
L
-
V
D
T
M
I
V
DGL
W
D
V
Y
N
-----
Q
-----
Y
---
H
M
G
I
--------------
T
--
A
E
N
V
A
K
E
Y
G
I
T
R
E
A
Q
D
E
F
A
V
G
S
Q
N
K
A
E
A
A
Q
K
A
G
K
F
D
E
E
I
V
P
V
L
I
P
Q
R
K
G
D
-
P
-
V
A
F
K
T
D
E
F
V
R
Q
G
A
T
L
D
S
M
S
G
L
K
P
---------------------
A
-----------
F
D
K
A
G
-
T
V
T
A
A
N
A
S
G
L
N
D
G
A
A
A
V
V
V
M
S
A
A
K
A
K
E
L
G
L
T
P
L
A
T
I
K
S
Y
A
N
A
G
V
D
P
K
V
M
G
M
G
P
V
P
A
S
K
R
A
L
S
R
A
E
W
T
P
Q
D
L
D
L
M
E
I
N
E
A
F
A
A
Q
A
L
A
V
H
Q
Q
M
G
W
--
D
-
T
S
K
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
C
R
I
L
V
T
L
L
H
E
M
K
R
R
D
A
K
K
G
L
A
S
L
C
I
G
G
G
M
G
V
A
L
A
V
E
R
K
61
PsiBlast_CBE
92.21
42%
-80
- C4 -
4B3J
10
Y0859_MYCTU
D:
[1-403]
M
S
E
E
A
F
I
Y
E
A
I
R
T
P
R
G
K
Q
K
-
N
G
S
L
H
E
V
K
P
L
S
L
V
V
G
L
I
D
E
L
R
K
R
H
P
D
L
D
E
N
L
I
S
D
V
I
L
G
C
V
S
P
V
G
D
Q
G
G
D
I
A
R
A
A
V
L
A
S
G
M
P
V
T
S
G
G
V
Q
L
N
R
F
C
A
S
G
L
E
A
V
N
T
A
A
Q
K
V
R
S
G
W
D
D
L
V
L
A
G
G
V
E
S
M
S
R
V
P
--
M
G
S
D
G
G
A
M
G
----------------------
L
D
P
--
A
T
N
-----
Y
D
V
M
F
V
P
Q
--------------
S
I
G
A
D
L
I
A
T
I
E
G
F
S
R
E
D
V
D
A
Y
A
L
R
S
Q
Q
K
A
A
E
A
W
S
G
G
Y
F
A
K
S
V
V
P
V
--
R
D
Q
N
G
L
-
L
-
I
-
L
D
H
D
E
H
M
R
P
D
T
T
K
E
G
L
A
K
L
K
P
AFEALGG
F
D
D
V
A
L
Q
K
Y
HW---
V
-----------
E
K
I
N
H
-
V
H
T
G
G
N
S
S
G
I
V
D
G
A
A
L
V
M
I
G
S
A
A
A
G
K
L
Q
G
L
T
P
R
A
R
I
V
A
T
A
T
S
G
A
D
P
V
I
M
L
T
G
P
T
P
A
T
R
K
V
L
D
R
A
G
L
T
V
D
D
I
D
L
F
E
L
N
E
A
F
A
S
V
V
L
K
F
Q
K
D
L
N
I
P
D
---
E
K
L
N
V
N
G
G
A
I
A
M
G
H
P
L
G
A
T
G
A
M
I
L
G
T
M
V
D
E
L
E
R
R
N
A
R
R
A
L
I
T
L
C
I
G
G
G
M
G
V
A
T
I
I
E
R
V
30
PsiBlast_CBE
92.10
45%
-86
- C4 -
4O9C
1
THIL_CUPNH
H:
[3-392]
---
D
V
V
I
V
S
A
A
R
T
A
V
G
K
-
F
-
G
G
S
L
A
K
I
P
A
P
E
L
G
A
V
V
I
K
A
A
L
E
R
-
A
G
V
K
P
E
Q
V
S
E
V
I
M
G
Q
V
L
T
A
G
S
-
G
Q
N
P
A
R
Q
A
A
I
K
A
G
L
P
A
M
V
P
A
M
T
I
N
K
V
S
G
S
G
L
K
A
V
M
L
A
A
N
A
I
M
A
G
D
A
E
I
V
V
A
G
G
Q
E
N
M
S
A
A
P
H
V
L
P
G
S
R
D
G
F
R
--
M
G
D
A
K
-
L
-
V
D
T
M
I
V
DGL
W
D
V
Y
N
-----
Q
-----
Y
---
H
M
G
I
--------------
T
--
A
E
N
V
A
K
E
Y
G
I
T
R
E
A
Q
D
E
F
A
V
G
S
Q
N
K
A
E
A
A
Q
K
A
G
K
F
D
E
E
I
V
P
V
L
I
P
Q
R
K
G
D
-
P
-
V
A
F
K
T
D
E
F
V
R
Q
G
A
T
L
D
S
M
S
G
L
K
P
---------------------
A
-----------
F
D
K
A
G
-
T
V
T
A
A
N
A
S
G
L
N
D
G
A
A
A
V
V
V
M
S
A
A
K
A
K
E
L
G
L
T
P
L
A
T
I
K
S
Y
A
N
A
G
V
D
P
K
V
M
G
M
G
P
V
P
A
S
K
R
A
L
S
R
A
E
W
T
P
Q
D
L
D
L
M
E
I
N
E
A
F
A
A
Q
A
L
A
V
H
Q
Q
M
G
W
--
D
-
T
S
K
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
C
R
I
L
V
T
L
L
H
E
M
K
R
R
D
A
K
K
G
L
A
S
L
C
I
G
G
G
M
G
V
A
L
A
V
E
R
K
109
HHSearch
92.01
45%
-90
- C4 -
3SVK
-
?
A:
[7-407]
--
E
E
A
F
I
Y
E
A
I
R
T
P
R
G
K
-
Q
K
N
G
S
L
T
E
V
K
P
L
N
L
V
V
G
L
V
D
E
L
R
R
R
Y
P
D
L
D
E
T
L
I
S
D
M
I
L
G
V
V
--------
D
I
A
R
T
A
V
L
A
A
G
L
P
E
T
T
G
G
V
Q
L
N
---
A
S
G
L
E
A
V
N
T
A
A
Q
K
V
R
S
G
W
D
D
L
V
L
A
G
G
V
E
S
M
-----------------------
W
----
A
T
D
---
P
E
T
N
Y
R
----------
I
G
F
V
P
Q
G
I
--------------
G
--
A
D
L
I
A
T
L
E
G
F
S
R
E
D
V
D
A
Y
A
L
R
S
Q
Q
K
A
A
A
A
W
S
G
G
Y
F
A
K
S
V
V
P
V
R
D
Q
N
G
--
L
-
V
-
I
-
L
D
H
D
E
H
M
R
P
D
T
T
M
E
G
L
A
K
L
K
T
---------------------
A
FDQKYHWVEKI
N
H
V
----
H
T
G
G
N
S
S
G
I
V
D
G
A
A
L
V
L
V
G
S
E
K
A
G
K
S
Q
G
L
T
P
R
A
R
I
V
A
T
A
T
S
------
M
L
T
G
P
T
P
A
T
R
K
V
L
D
R
A
G
L
T
I
D
D
I
D
L
F
E
L
N
E
A
F
A
S
V
V
L
K
F
Q
K
D
L
N
--
I
P
-
D
E
K
L
N
V
N
G
G
A
I
A
M
G
H
P
L
G
A
T
G
A
M
I
T
G
T
M
V
D
E
L
E
R
R
N
A
R
R
A
L
I
T
L
C
I
G
G
G
M
G
V
A
T
I
I
E
R
V
68
PsiBlast_CBE
91.84
42%
-87
- C4 -
3SVK
1
?
B:
[7-406]
--
E
E
A
F
I
Y
E
A
I
R
T
P
R
G
K
Q
K
-
N
G
S
L
T
E
V
K
P
L
N
L
V
V
G
L
V
D
E
L
R
R
R
Y
P
D
L
D
E
T
L
I
S
D
M
I
L
G
V
V
--------
D
I
A
R
T
A
V
L
A
A
G
L
P
E
T
T
G
G
V
Q
L
N
----
S
G
L
E
A
V
N
T
A
A
Q
K
V
R
S
G
W
D
D
L
V
L
A
G
G
V
E
S
M
-------------
W
A
----------------------
T
D
P
E
T
N
Y
R
-----
I
G
F
V
P
Q
G
I
--------------
G
--
A
D
L
I
A
T
L
E
G
F
S
R
E
D
V
D
A
Y
A
L
R
S
Q
Q
K
A
A
A
A
W
S
G
G
Y
F
A
K
S
V
V
P
V
--
R
D
Q
N
G
L
-
V
-
I
-
L
D
H
D
E
H
M
R
P
D
T
T
M
E
G
L
A
K
L
K
T
AFDLQKYHW------------
V
-----------
E
K
I
N
H
-
V
H
T
G
G
N
S
S
G
I
V
D
G
A
A
L
V
L
V
G
S
E
K
A
G
K
S
Q
G
L
T
P
R
A
R
I
V
A
T
A
T
S
------
M
L
T
G
P
T
P
A
T
R
K
V
L
D
R
A
G
L
T
I
D
D
I
D
L
F
E
L
N
E
A
F
A
S
V
V
L
K
F
Q
K
D
L
N
I
P
D
---
E
K
L
N
V
N
G
G
A
I
A
M
G
H
P
L
G
A
T
G
A
M
I
T
G
T
M
V
D
E
L
E
R
R
N
A
R
R
A
L
I
T
L
C
I
G
G
G
M
G
V
A
T
I
I
E
R
-
63
PsiBlast_CBE
91.40
42%
-79
- C4 -
4B3I
5
Y0859_MYCTU
D:
[1-403]
M
S
E
E
A
F
I
Y
E
A
I
R
T
P
R
G
K
Q
K
-
N
G
S
L
H
E
V
K
P
L
S
L
V
V
G
L
I
D
E
L
R
K
R
H
P
D
L
D
E
N
L
I
S
D
V
I
L
G
C
V
S
P
V
G
D
Q
G
G
D
I
A
R
A
A
V
L
A
S
G
M
P
V
T
S
G
G
V
Q
L
N
R
F
C
A
S
G
L
E
A
V
N
T
A
A
Q
K
V
R
S
G
W
D
D
L
V
L
A
G
G
V
E
S
M
S
R
V
P
--
M
G
S
D
G
G
A
M
G
----------------------
L
D
P
--
A
T
N
-----
Y
D
V
M
F
V
P
Q
--------------
S
I
G
A
D
L
I
A
T
I
E
G
F
S
R
E
D
V
D
A
Y
A
L
R
S
Q
Q
K
A
A
E
A
W
S
G
G
Y
F
A
K
S
V
V
P
V
--
R
D
Q
N
G
L
-
L
-
I
-
L
D
H
D
E
H
M
R
P
D
T
T
K
E
G
L
A
K
L
K
P
AFEGLAALGG
F
D
D
V
A
L
Q
K
Y
HW
V
-----------
E
K
I
N
H
-
V
H
T
G
G
N
S
S
G
I
V
D
G
A
A
L
V
M
I
G
S
A
A
A
G
K
L
Q
G
L
T
P
R
A
R
I
V
A
T
A
T
S
G
A
D
P
V
I
M
L
T
G
P
T
P
A
T
R
K
V
L
D
R
A
G
L
T
V
D
D
I
D
L
F
E
L
N
E
A
F
A
S
V
V
L
K
F
Q
K
D
L
N
I
P
D
---
E
K
L
N
V
N
G
G
A
I
A
M
G
H
P
L
G
A
T
G
A
M
I
L
G
T
M
V
D
E
L
E
R
R
N
A
R
R
A
L
I
T
L
C
I
G
G
G
M
G
V
A
T
I
I
E
R
V
9
PsiBlast_PDB
91.40
43%
-81
- C4 -
4W61
-
?
A:
[21-413]
M
T
R
E
V
V
V
V
S
G
V
R
T
A
I
G
T
-
F
-
G
G
S
L
K
D
V
A
P
A
E
L
G
A
L
V
V
R
E
A
L
A
R
A
Q
-
V
S
G
D
D
V
G
H
V
V
F
G
N
V
I
Q
T
E
P
R
D
M
Y
L
G
R
V
A
A
V
N
G
G
V
T
I
N
A
P
A
L
T
V
N
R
L
C
G
S
G
L
Q
A
I
V
S
A
A
Q
T
I
L
L
G
D
T
D
V
A
I
G
G
G
A
E
S
M
S
R
A
P
Y
L
A
P
A
A
R
W
G
A
R
--
M
G
D
-
A
G
L
-
V
D
M
M
L
G
---
A
-
L
H
D
P
F
H
R
I
H
-----
M
G
V
-------------------
T
--
A
E
N
V
A
K
E
Y
D
I
S
R
A
Q
Q
D
E
A
A
L
E
S
H
R
R
A
S
A
A
I
K
A
G
Y
F
K
D
Q
I
V
P
V
V
S
K
G
R
K
G
D
-
V
-
T
-
F
D
T
D
E
H
V
R
H
D
A
T
I
D
D
M
T
K
L
R
P
---------------------
V
-----------
F
V
K
E
N
G
T
V
T
A
G
N
A
S
G
L
N
D
A
A
A
A
V
V
M
M
E
R
A
E
A
E
R
R
G
L
K
P
L
A
R
L
V
S
Y
G
H
A
G
V
D
P
K
A
M
G
I
G
P
V
P
A
T
K
I
A
L
E
R
A
G
L
Q
V
S
D
L
D
V
I
E
A
N
E
A
F
A
A
Q
A
C
A
V
T
K
A
L
G
L
--
D
-
P
A
K
V
N
P
N
G
S
G
I
S
L
G
H
P
I
G
A
T
G
A
L
I
T
V
K
A
L
H
E
L
N
R
V
Q
G
R
Y
A
L
V
T
M
C
I
G
G
G
Q
G
I
A
A
I
F
E
R
-
11
PsiBlast_PDB
91.32
45%
-84
- C4 -
4O9C
-
THIL_CUPNH
A:
[3-392]
---
D
V
V
I
V
S
A
A
R
T
A
V
G
K
-
F
-
G
G
S
L
A
K
I
P
A
P
E
L
G
A
V
V
I
K
A
A
L
E
R
-
A
G
V
K
P
E
Q
V
S
E
V
I
M
G
Q
V
L
T
A
G
S
-
G
Q
N
P
A
R
Q
A
A
I
K
A
G
L
P
A
M
V
P
A
M
T
I
N
K
V
S
G
S
G
L
K
A
V
M
L
A
A
N
A
I
M
A
G
D
A
E
I
V
V
A
G
G
Q
E
N
M
S
A
A
P
H
V
L
P
G
S
R
D
G
F
R
--
M
G
D
A
K
-
L
-
V
D
T
M
I
V
D
G
L
W
D
V
Y
N
-----
Q
-----
Y
---
H
M
G
I
--------------
T
--
A
E
N
V
A
K
E
Y
G
I
T
R
E
A
Q
D
E
F
A
V
G
S
Q
N
K
A
E
A
A
Q
K
A
G
K
F
D
E
E
I
V
P
V
L
I
P
Q
R
K
G
D
-
P
-
V
A
F
K
T
D
E
F
V
R
Q
G
A
T
L
D
S
M
S
G
L
K
P
---------------------
A
-----------
F
D
K
A
G
-
T
V
T
A
A
N
A
S
G
L
N
D
G
A
A
A
V
V
V
M
S
A
A
K
A
K
E
L
G
L
T
P
L
A
T
I
K
S
Y
A
N
A
G
V
D
P
K
V
M
G
M
G
P
V
P
A
S
K
R
A
L
S
R
A
E
W
T
P
Q
D
L
D
L
M
E
I
N
E
A
F
A
A
Q
A
L
A
V
H
Q
Q
M
G
W
--
D
-
T
S
K
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
C
R
I
L
V
T
L
L
H
E
M
K
R
R
D
A
K
K
G
L
A
S
L
C
I
G
G
G
M
G
V
A
L
A
V
E
R
K
50
PsiBlast_CBE
91.00
42%
-82
- C4 -
2VTZ
5
THIL_ZOORA
B:
[5-392]
----
I
V
I
A
S
A
A
R
T
A
V
G
S
-
F
-
N
G
A
F
A
N
T
P
A
H
E
L
G
A
T
V
I
S
A
V
L
E
R
-
A
G
V
A
A
G
E
V
N
E
V
I
L
G
Q
V
L
P
A
G
E
-
G
Q
N
P
A
R
Q
A
A
M
K
A
G
V
P
Q
E
A
T
A
W
G
M
N
Q
L
A
G
S
G
L
R
A
V
A
L
G
M
Q
Q
I
A
T
G
D
A
S
I
I
V
A
G
G
M
E
S
M
S
M
A
P
H
C
-----
A
H
L
R
--
G
G
V
-
K
-
M
-
G
D
-------
F
K
M
I
D
T
M
I
K
D
G
LTDAF
Y
G
Y
H
-
M
G
T
--------------
T
--
A
E
N
V
A
K
Q
W
Q
L
S
R
D
E
Q
D
A
F
A
V
A
S
Q
N
K
A
E
A
A
Q
K
D
G
R
F
K
D
E
I
V
P
F
I
V
K
G
R
K
G
D
-
I
-
T
-
V
D
A
D
E
Y
I
R
H
G
A
T
L
D
S
M
A
K
L
R
P
---------------------
A
-----------
F
D
K
E
G
-
T
V
T
A
G
N
A
S
G
L
N
D
G
A
A
A
A
L
L
M
S
E
A
E
A
S
R
R
G
I
Q
P
L
G
R
I
V
S
W
A
T
V
G
V
D
P
K
V
M
G
T
G
P
I
P
A
S
R
K
A
L
E
R
A
G
W
K
I
G
D
L
D
L
V
E
A
N
E
A
F
A
A
Q
A
C
A
V
N
K
D
L
G
W
--
D
-
P
S
I
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
A
R
I
L
N
T
L
L
F
E
M
K
R
R
G
A
R
K
G
L
A
T
L
C
I
G
G
G
M
G
V
A
M
C
I
E
S
L
10
PsiBlast_PDB
91.00
45%
-83
- C4 -
4O9A
-
THIL_CUPNH
A:
[8-397]
---
D
V
V
I
V
S
A
A
R
T
A
V
G
K
-
F
-
G
G
S
L
A
K
I
P
A
P
E
L
G
A
V
V
I
K
A
A
L
E
R
-
A
G
V
K
P
E
Q
V
S
E
V
I
M
G
Q
V
L
T
A
G
S
-
G
Q
N
P
A
R
Q
A
A
I
K
A
G
L
P
A
M
V
P
A
M
T
I
N
K
V
S
G
S
G
L
K
A
V
M
L
A
A
N
A
I
M
A
G
D
A
E
I
V
V
A
G
G
Q
E
N
M
S
A
A
P
H
V
L
P
G
S
R
D
G
F
R
--
M
G
D
A
K
-
L
-
V
D
T
M
I
V
D
G
L
W
D
V
Y
N
-----
Q
-----
Y
---
H
M
G
I
--------------
T
--
A
E
N
V
A
K
E
Y
G
I
T
R
E
A
Q
D
E
F
A
V
G
S
Q
N
K
A
E
A
A
Q
K
A
G
K
F
D
E
E
I
V
P
V
L
I
P
Q
R
K
G
D
-
P
-
V
A
F
K
T
D
E
F
V
R
Q
G
A
T
L
D
S
M
S
G
L
K
P
---------------------
A
-----------
F
D
K
A
G
-
T
V
T
A
A
N
A
S
G
L
N
D
G
A
A
A
V
V
V
M
S
A
A
K
A
K
E
L
G
L
T
P
L
A
T
I
K
S
Y
A
N
A
G
V
D
P
K
V
M
G
M
G
P
V
P
A
S
K
R
A
L
S
R
A
E
W
T
P
Q
D
L
D
L
M
E
I
N
E
A
F
A
A
Q
A
L
A
V
H
Q
Q
M
G
W
--
D
-
T
S
K
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
C
R
I
L
V
T
L
L
H
E
M
K
R
R
D
A
K
K
G
L
A
S
L
C
I
G
G
G
M
G
V
A
L
A
V
E
R
K
35
PsiBlast_CBE
90.93
42%
-79
- C4 -
1DLV
2
THIL_ZOORA
D:
[2-389]
----
I
V
I
A
S
A
A
R
T
A
V
G
S
-
F
-
N
G
A
F
A
N
T
P
A
H
E
L
G
A
T
V
I
S
A
V
L
E
R
-
A
G
V
A
A
G
E
V
N
E
V
I
L
G
Q
V
L
P
A
G
E
-
G
Q
N
P
A
R
Q
A
A
M
K
A
G
V
P
Q
E
A
T
A
W
G
M
N
Q
L
C
G
S
G
L
R
A
V
A
L
G
M
Q
Q
I
A
T
G
D
A
S
I
I
V
A
G
G
M
E
S
M
S
M
A
P
H
C
-----
A
H
L
R
--
G
G
V
-
K
-
M
-
G
D
-------
F
K
M
I
D
T
M
I
K
D
G
LTDAF
Y
G
Y
H
-
M
G
T
--------------
T
--
A
E
N
V
A
K
Q
W
Q
L
S
R
D
E
Q
D
A
F
A
V
A
S
Q
N
K
A
E
A
A
Q
K
D
G
R
F
K
D
E
I
V
P
F
I
V
K
G
R
K
G
D
-
I
-
T
-
V
D
A
D
E
Y
I
R
H
G
A
T
L
D
S
M
A
K
L
R
P
---------------------
A
-----------
F
D
K
E
G
-
T
V
T
A
G
N
A
S
G
L
N
D
G
A
A
A
A
L
L
M
S
E
A
E
A
S
R
R
G
I
Q
P
L
G
R
I
V
S
W
A
T
V
G
V
D
P
K
V
M
G
T
G
P
I
P
A
S
R
K
A
L
E
R
A
G
W
K
I
G
D
L
D
L
V
E
A
N
E
A
F
A
A
Q
A
C
A
V
N
K
D
L
G
W
--
D
-
P
S
I
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
A
R
I
L
N
T
L
L
F
E
M
K
R
R
G
A
R
K
G
L
A
T
L
C
I
G
G
G
M
G
V
A
M
C
I
E
S
L
22
PsiBlast_CBE
90.53
42%
-91
- C4 -
4E1L
4
?
D:
[5-395]
--
K
D
V
V
I
V
S
A
V
R
T
P
I
G
S
-
F
-
G
G
V
F
K
N
T
S
A
V
Q
L
G
T
I
A
V
K
E
A
I
S
R
-
V
G
L
N
L
S
E
I
D
E
V
I
I
G
N
V
L
Q
T
G
L
-
G
Q
N
V
A
R
Q
I
A
I
N
A
G
I
P
N
S
V
P
S
Y
T
V
N
K
L
C
G
S
G
L
K
S
V
Q
L
A
A
Q
S
I
T
S
G
E
N
D
V
V
I
A
G
G
T
E
N
M
S
Q
A
P
Y
I
----------------------------------------------
Q
Y
H
M
G
I
--------------
T
--
A
E
N
I
A
T
K
F
E
F
T
R
E
M
Q
D
K
L
A
L
E
S
Q
N
K
A
E
N
A
I
K
N
N
R
F
K
E
E
I
V
P
V
D
V
L
I
R
R
G
K
-
I
E
T
-
I
D
K
D
E
Y
P
K
L
G
M
T
F
E
G
L
S
K
L
K
P
---------------------
A
-----------
F
K
K
D
G
-
T
V
T
A
G
N
A
S
G
I
N
D
G
A
A
M
L
I
L
M
S
Q
Q
K
A
D
E
L
G
I
R
P
L
A
K
I
K
S
Y
A
S
A
G
V
E
P
E
V
M
G
T
G
P
I
P
A
T
R
K
A
L
K
K
A
G
L
S
I
N
D
I
D
L
I
E
A
N
E
A
F
A
A
Q
A
L
A
V
K
N
E
L
Q
I
--
D
-
S
S
K
L
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
I
Y
E
M
Q
K
R
K
V
E
T
G
L
A
T
L
C
I
G
G
G
Q
G
I
S
M
V
V
S
R
-
74
PsiBlast_CBE
90.44
41%
-79
- C4 -
1WDL
1
FADA_PSEFR
C:
[5-390]
--
R
D
V
V
I
V
D
F
G
R
T
P
M
G
R
-
S
K
G
G
M
H
R
N
T
R
A
E
D
M
S
A
H
L
I
S
K
V
L
E
R
N
S
K
V
D
P
G
E
V
E
D
V
I
W
G
C
V
N
Q
T
L
E
Q
G
W
N
I
A
R
M
A
S
L
M
T
Q
I
P
H
T
S
A
A
Q
T
V
S
R
L
C
G
S
S
M
S
A
L
H
T
A
A
Q
A
I
M
T
G
N
G
D
V
F
V
V
G
G
V
E
H
M
G
H
V
S
M
M
--------------------------------------------
H
G
V
D
P
N
P
H
MSLYAAKASGMMGL
T
--
A
E
M
L
G
K
M
H
G
I
S
R
E
Q
Q
D
A
F
A
V
R
S
H
Q
L
A
H
K
A
T
V
E
G
K
F
K
D
E
I
I
P
M
Q
G
Y
D
E
N
G
F
L
K
-
I
-
F
D
Y
D
E
T
I
R
P
D
T
T
L
E
S
L
A
A
L
K
P
---------------------
A
-----------
F
N
P
K
G
G
T
V
T
A
G
T
S
S
Q
I
T
D
G
A
S
C
M
I
V
M
S
A
Q
R
A
K
D
L
G
L
E
P
L
A
V
I
R
S
M
A
V
A
G
V
D
P
A
I
M
G
Y
G
P
V
P
A
T
Q
K
A
L
K
R
A
G
L
N
M
A
D
I
D
F
I
E
L
N
E
A
F
A
A
Q
A
L
P
V
L
K
D
L
K
V
L
D
K
M
N
E
K
V
N
L
H
G
G
A
I
A
L
G
H
P
F
G
C
S
G
A
R
I
S
G
T
L
L
N
V
M
K
Q
N
G
G
T
F
G
L
S
T
M
C
I
G
L
G
Q
G
I
A
T
V
F
E
R
V