@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0237: (2015-12-27 )
MDAPLRIALIGAGNMGRQHYHRLQRIAGARLCAVADPQGQAFAADTGVPWFGDHRRLLEEARPQAAIVANPNNLHVATALDCLAAGVPLLLEKPVGVQLDEVSELVAVARRSGVPLLVGHHRRHNPLVVRARQLIAEGALGRLLSVTALWQLKKPDSYFEVAWRREPGAGMLLTNLIHDLDLLRHLCGEVREVQALAGNAIRGLPNEDNIALLLRFANGALGSLTGCDAAAAPWSWELAAGENPVYPRQAEQPCYLLAGTEGALSLPQLRRWRYAEARQGWHDPLAASEEAVATGDPLQRQLEHFVRVARGEEAPLMDATDAARTLALVEAVREAARSGRACAPASF
Atome Classification :
(20 SA)
---------------------------.........10......-.-.20..--..-.-.--.-.--------30.....---.---..---40----...---..------..-.-50.........60........70........80........90........100.......110-.......120.......130.......140--...-....-----------150.----..--..--...---160.-..---.--.---.---.--.170.......180-......----.--190...----....---200----.----..----------..--..210.......220..---------------.....230..---..------------------...240--.......--250.--.....--.260.----........270---.---.---.--..-----..--.---.280--....----.---------.-..------.290....---...---------------..300-----.....-..310--...--.....320.......330........340.-------....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------MDA
P
L
R
I
A
L
I
GAGNM
G
R
-
Q
-
H
Y
H
R
L
--
Q
R
-I-A--G-
A
--------
R
L
C
A
VAD---P---QG---QA----FAA---DT------GV-P-W-
F
G
D
H
R
R
L
L
E
EARP
Q
A
A
I
V
ANPNN
L
H
V
A
T
A
L
D
C
L
A
AGVP
L
L
LEKPVGV
Q
L
D
E
V
S
E
L
V
A
V
A
R
RS-GV
P
L
L
VGHHRRHN
P
L
V
V
R
A
R
Q
L
I
A
E
G
AL
G
R
--
L
L
S
-
V
T
A
L
-----------
W
-QL----KK--PD--S
Y
F
---
E
-
V
A
-
W
R---R--E---P---G--A
G
M
L
L
T
N
L
I
H
D
L
D
L
-
L
R
H
L
C
G
----
E
--
V
R
E
V
Q
A
----
L
AGN---AIR----G----LP----------NE--D
N
I
A
L
L
L
R
FANGALGSL---------------TGCDAAAAP
W
---
S
W
------------------
E
LAAGE--NPVYPRQ--AEQ
P
--
C
Y
L
L
A--GT--E----GALS
L
P
Q
L
R
-----
R
---
W
---
R
--
Y
A
-----
E
A
--R---QG----WHDP----L---------A-AS------EE--AVAT---G
D
P
---------------
L
Q
R
Q
L
-----
E
H
F
V
R
-
V
AR-G--EEA--PLMDA
T
D
A
A
R
T
L
A
L
V
E
A
-
V
R
E
A
A
RSGRACA-------PASF
2
PsiBlast_PDB
91.16
26%
-92
- C1 -
3Q2K
2
?
A:
[28-362]
----------------------------
D
R
K
I
R
F
G
L
V
G
C
G
R
I
S
K
-
N
-
H
I
G
A
I
A
-
Q
H
-
G
-
D
--
R
-
A
--------
E
L
V
E
I
C
D
TN-
P
---
E
A
L
--
Q
A
----
A
E
A
---
A
T
------
G
A
-
R
-
P
-
F
S
S
L
S
D
M
L
A
Q
G
N
A
D
A
L
V
L
A
T
P
S
G
L
H
P
W
Q
A
I
E
V
A
Q
A
G
R
H
V
V
S
E
K
P
M
A
T
R
W
E
D
G
K
R
M
V
K
A
C
D
E
A
-
G
V
R
L
F
V
V
K
Q
N
R
R
N
A
T
L
Q
L
V
K
K
A
I
E
Q
G
R
F
G
R
--
I
Y
M
-
V
T
V
N
-----------
V
-
F
W
----
T
R
--
P
Q
--
E
Y
Y
---
D
-
A
A
R
W
R
---
G
KW
E
---
W
---
D
--
G
G
A
F
M
N
Q
A
S
H
Y
V
D
L
-
L
D
W
L
V
G
----
P
--
V
E
S
V
Y
A
----
Y
T
A
T
---
L
A
R
----
R
----
I
E
----------
A
E
--
D
T
G
V
A
A
L
R
W
R
H
G
A
M
G
S
I
---------------
N
V
T
--------------------------------------
M
L
T
Y
P
Q
N
--
L
E
G
S
--
I
T
I
L
G
EK
G
T
V
R
V
----
G
G
V
A
V
N
R
I
D
-----
E
---
W
---
K
--
F
A
-----
E
P
--
H
---
P
D
----
D
D
K
I
----
R
---------
E
-
A
N
------
Y
E
--
T
T
S
V
YGF
G
H
P
---------------
L
--
Y
Y
-----
D
N
V
I
N
-
C
L
R
-
G
--
D
C
E
--
P
E
T
D
G
R
E
G
L
Q
S
L
A
L
L
T
A
-
I
Y
R
S
A
R
D
G
V
R
I
P
-------
L
P
L
D
27
HHSearch
89.31
22%
-98
- C1 -
3KUX
1
?
A:
[4-349]
---------------------------
M
A
D
K
I
K
V
G
L
L
G
Y
G
Y
A
S
K
-
T
F
H
A
P
L
I
--
M
G
-
T
-
P
--
G
-
L
--------
E
L
A
G
V
S
S
---
S
---
D
A
S
--
K
V
----
H
A
D
---
W
P
------
A
I
-
P
-
V
-
V
S
D
P
Q
M
L
F
N
D
P
S
I
D
L
I
V
I
P
T
P
N
D
T
H
F
P
L
A
Q
S
A
L
A
A
G
K
H
V
V
V
D
K
P
F
T
V
T
L
S
Q
A
N
A
L
K
E
H
A
D
D
A
-
G
L
L
L
S
V
F
H
N
R
R
W
D
S
D
F
L
T
L
K
T
L
L
A
E
G
S
L
G
N
--
V
V
Y
-
F
E
S
H
-----------
F
-
D
R
----
Y
R
--
P
E
----
I
---
R
-
Q
R
-
W
R
---
E
--
Q
-------
G
--
G
G
I
W
Y
D
L
G
P
H
L
L
D
Q
-
A
L
Q
L
F
G
----
L
--
P
E
T
L
N
V
----
D
L
G
M
---
L
R
P
----
G
----
S
Q
----------
S
V
--
D
Y
F
H
A
V
L
S
Y
P
G
Q
R
-
V
V
L
---------------
H
S
T
V
L
A
A
A
-------------------------------------------
E
T
A
--
R
Y
I
V
H
--
G
T
--
Q
----
G
S
Y
I
K
F
G
V
D
-----
P
Q
E
D
R
---
L
--
K
A
G----
E
R
LP
Q
---
A
D
----
W
G
Y
D
MR
D
G
I
V
T
L
S
H
DN
V
L
T
-
E
K
------
P
L
---
L
T
L
---
P
G
N
---------------
Y
P
A
Y
Y
-----
A
G
I
R
D
-
A
I
W
-
G
--
T
A
P
--
N
P
V
P
A
T
E
A
I
K
V
M
E
L
I
E
L
-
G
I
A
S
D
Q
Q
K
K
A
L
P
-------
I
I
A
K
1
PsiBlast_PDB
88.70
25%
-99
- C1 -
3Q2I
4
?
A:
[11-346]
----------------------------
D
R
K
I
R
F
A
L
V
G
C
G
R
I
A
N
-
N
-
H
F
G
A
L
--
E
K
-
H
-
A
--
D
R
A
--------
E
L
I
D
V
C
D
---
I
---
D
P
---
A
A
----
L
K
A
A
V
E
R
T
------
G
A
-
R
-
G
-
H
A
S
L
T
D
M
L
A
Q
T
D
A
D
I
V
I
L
T
T
P
S
G
L
H
P
T
Q
S
I
E
C
S
E
A
G
F
H
V
M
T
E
K
P
M
A
T
R
W
E
D
G
L
E
M
V
K
A
A
D
K
A
-
K
K
H
L
F
V
V
K
Q
N
R
R
N
A
T
L
Q
L
L
K
R
A
M
Q
E
K
R
F
G
R
IY
M
V
N
-
V
N
V
F
-----------
W
-
T
------
R
--
P
Q
--
E
Y
Y
---
D
-
A
A
G
W
R
---
G
TW
E
---
F
---
D
--
G
G
A
F
M
N
Q
A
S
H
Y
V
D
L
-
L
D
W
L
I
G
----
P
--
V
E
S
V
Q
A
----
Y
T
A
T
---
L
A
R
----
N
----
I
E
----------
V
E
--
D
T
G
T
V
S
V
K
W
R
S
G
A
L
G
S
M
---------------
N
V
T
--------------------------------------
M
L
T
Y
P
K
N
--
L
E
G
S
--
I
T
I
L
G
--
E
K
--
G
S
V
R
V
G
G
V
A
V
N
E
I
Q
-----
H
---
W
---
E
--
F
S
-----
E
P
--
H
AMD
E
E
----
I
K
D
A
----
S
-------------------------
G
F
---
G
H
P
---------------
L
--
Y
Y
-----
D
N
V
I
K
-
T
M
R
-
G
--
E
A
T
--
P
E
T
D
G
R
E
G
L
K
S
L
E
L
L
I
A
-
M
Y
L
S
A
R
D
G
R
R
V
S
-------
L
P
L
D
22
HHSearch
86.57
21%
-89
- C1 -
3DB2
-
?
A:
[2-352]
---------------------------
M
Y
N
P
V
G
V
A
A
I
G
L
G
R
W
A
Y
-
V
-
M
A
D
A
Y
--
T
K
-
S
-
E
--
K
-
L
--------
K
L
V
T
C
Y
S
---
R
---
T
E
D
K
R
E
K
----
F
G
K
---
R
Y
------
N
C
-
A
-
G
-
D
A
T
M
E
A
L
L
A
R
E
D
V
E
M
V
I
I
T
V
P
N
D
K
H
A
E
V
I
E
Q
C
A
R
S
G
K
H
I
Y
V
E
K
P
I
S
V
S
L
D
H
A
Q
R
I
D
Q
V
I
K
E
T
-
G
V
K
F
L
C
G
H
S
S
R
R
L
G
A
L
R
K
M
K
E
M
I
D
T
K
E
I
G
E
--
V
S
S
-
I
E
A
V
-----------
F
-
S
N
----
E
R
--
G
L
--
E
L
K
---
K
-
G
N
-
W
R
---
G
--
E
PAT
A
---
P
--
G
G
P
L
T
Q
L
G
V
H
Q
I
D
N
-
L
Q
F
L
L
G
----
P
--
V
A
R
V
F
N
----
F
G
K
P
---
M
Y
T
----
E
----
V
E
----------
N
I
--
T
V
N
Q
T
L
L
E
F
E
D
G
K
Q
A
Y
L
---------------
G
T
N
W
A
C
P
G
--------------------------------------------
V
F
--
S
I
N
V
Y
--
G
T
--
K
----
A
N
L
F
Y
Q
L
D
F
-----
S
---
W
---
W
--
S
N
SDVTD
E
H
--
S
---
T
L
----
I
K
R
E
FAS--------------
N
R
I
L
R
D
V
K
V
--
D
F
E
S
---
V
D
H
---------------
L
R
V
E
V
-----
E
E
V
A
D
-
V
I
R
-
N
--
G
G
E
--
T
E
I
G
A
E
A
S
L
R
N
L
A
V
V
L
A
-
A
V
K
S
V
H
E
K
R
P
V
E
-------
I
A
E
I
26
HHSearch
86.25
23%
-95
- C1 -
3Q2I
4
?
A:
[10-351]
---------------------------
T
D
R
K
I
R
F
A
L
V
G
C
G
R
I
A
N
-
N
-
H
F
G
A
L
--
E
K
-
H
A
D
--
R
-
A
--------
E
L
I
D
V
C
D
---
I
---
D
P
A
A
L
K
A
----
A
V
E
---
R
T
------
G
A
-
R
-
G
-
H
A
S
L
T
D
M
L
A
Q
T
D
A
D
I
V
I
L
T
T
P
S
G
L
H
P
T
Q
S
I
E
C
S
E
A
G
F
H
V
M
T
E
K
P
M
A
T
R
W
E
D
G
L
E
M
V
K
A
A
D
K
A
-
K
K
H
L
F
V
V
K
Q
N
R
R
N
A
T
L
Q
L
L
K
R
A
M
Q
E
K
R
F
G
R
--
I
Y
M
-
V
N
V
N
-----------
V
-
F
W
----
T
R
--
P
Q
--
E
Y
Y
---
D
A
A
G
-
W
R
---
G
--
T
WE-
F
---
D
--
G
G
A
F
M
N
Q
A
S
H
Y
V
D
L
-
L
D
W
L
I
G
----
P
--
V
E
S
V
Q
A
----
Y
T
A
T
---
L
A
R
----
N
----
I
E
----------
V
E
--
D
T
G
T
V
S
V
K
W
R
S
G
A
L
G
S
M
---------------
N
V
T
M
L
T
Y
P
K
-----------------------------------------
N
L
E
G
--
S
I
T
I
L
--
G
E
--
K
----
G
S
V
R
V
G
G
V
A
-----
V
---
N
EIQ
H
--
W
E
-----
F
S
E-
P
---
H
A
----
M
D
E
E
----
I
---------
K
-
D
A
------
S
----------
G
F
G
---------------
H
P
L
Y
Y
-----
D
N
V
I
K
-
T
M
R
-
G
--
E
A
T
--
P
E
T
D
G
R
E
G
L
K
S
L
E
L
L
I
A
-
M
Y
L
S
A
R
D
G
R
R
V
S
-------
L
P
L
D
9
PsiBlast_PDB
84.92
22%
-105
- C1 -
3E18
10
?
A:
[7-348]
--------------------------------
Q
L
V
I
V
G
Y
G
G
M
G
S
-
Y
-
H
V
T
L
A
--
S
A
-
A
-
D
--
N
-
L
--------
E
V
H
G
V
F
D
IL-
A
---
E
K
---
R
E
----
A
A
A
---
Q
K
------
G
L
-
K
-
I
-
Y
E
S
Y
E
A
V
L
A
D
E
K
V
D
A
V
L
I
A
T
P
N
D
S
H
K
E
L
A
I
S
A
L
E
A
G
K
H
V
V
C
E
K
P
V
T
M
T
S
E
D
L
L
A
I
M
D
V
A
K
R
V
-
N
K
H
F
M
V
H
Q
N
R
R
W
D
E
D
F
L
I
I
K
E
M
F
E
Q
K
T
I
G
E
--
M
F
H
-
L
E
S
R
-----------
V
-
H
G
----
A
N
GI
P
G
--
D
----------
W
R
HL-
K
--
A
---
H
---
G
--
G
G
M
V
L
D
W
G
V
H
L
L
D
Q
-
L
L
F
L
V
D
--------
S
N
V
K
S
----
V
S
A
N
---
L
S
F
----
A
----
L
G
----------
D
E
VD
D
G
F
V
T
F
I
T
F
E
N
G
I
T
A
Q
I
E
V
G
TTNFIKLPR
W
Y
V
K
G
T
E
G
T
G
I
I
H
---
D
W
------------------
D
L
-
S
G
E
I
V
K
P
T
A
L
A
K
--
T
S
E
P
--
T
P
I
K
A
--
G
------------------------------------------------
Q
G
----
L
T
K
T
----
M
---------
A
P
P
S
------
E
E
--
A
T
N
T
L
--
S
L
P
---------------
A
P
A
K
L
APS
F
Y
N
N
F
V
D
-
V
L
N
-
N
--
T
S
E
--
P
I
V
Q
N
E
E
V
Y
Q
V
L
K
L
I
E
A
-
I
F
E
A
A
E
T
N
R
T
V
H
-------
S
---
4
PsiBlast_PDB
83.96
24%
-104
- C1 -
1ZH8
7
?
A:
[19-332]
-------------------------------
I
R
L
G
I
V
G
C
G
I
A
A
R
-
E
L
H
L
P
A
L
--
K
N
-
L
-
S
--
H
L
F
--------
E
I
T
A
V
T
S
RT
R
S
---
H
A
---
E
E
----
F
A
K
---
M
V
------
G
N
-
P
A
V
-
F
D
S
Y
E
E
L
L
E
S
G
L
V
D
A
V
D
L
T
L
P
V
E
L
N
L
P
F
I
E
K
A
L
R
K
G
V
H
V
I
C
E
K
P
I
S
T
D
V
E
T
G
K
K
V
V
E
L
S
E
K
S
-
E
K
T
V
Y
I
A
E
N
F
R
H
V
P
A
F
W
K
A
K
E
L
V
E
S
G
A
I
G
D
----
P
-
V
F
M
N
-----------
W
-
Q
I
W
VGM
D
E
--
N
N
--
K
Y
V
---
H
-
T
D
-
W
R
---
K
--
K
---
P
---
K
HV
G
G
F
L
S
D
G
G
V
H
H
A
A
A
-
M
R
L
I
L
G
----
E
--
I
E
W
I
S
A
----
V
A
K
D
---
L
S
P
----
L
----
L
G
----------
G
M
--
D
F
L
S
S
I
F
E
F
E
N
G
T
V
G
N
Y
---------------
T
--------
I
---
S
Y
------------------
S
L
K
G
N
E
--
R
---------------
F
E
I
T
--
G
T
--
K
----
G
K
I
S
I
------------------------------------
S
----
W
-
D
K
----
I
---------
V
-
L
N
------
E
E
E
M
K
V
P
Q
---
E
N
S
---------------
Y
Q
K
E
F
-----
E
D
F
Y
Q
V
V
A
E
-
G
--
K
P
N
--
D
L
G
S
P
V
Q
A
L
K
D
L
A
F
I
E
A
C
V
R
S
A
G
N
K
V
F
V
S
S
-------
L
L
--
32
HHSearch
83.22
23%
-94
- C1 -
3EZY
2
?
A:
[2-333]
------------------------------
S
L
R
I
G
V
I
G
L
G
R
I
G
T
-
I
-
H
A
E
N
L
--
K
M
-
I
-
D
--
D
-
A
--------
I
L
Y
A
I
S
D
---
V
---
R
E
D
R
L
R
E
----
M
K
E
---
K
L
------
G
V
E
K
-
A
-
Y
K
D
P
H
E
L
I
E
D
P
N
V
D
A
V
L
V
C
S
S
T
N
T
H
S
E
L
V
I
A
C
A
K
A
K
K
H
V
F
C
E
K
P
L
S
L
N
L
A
D
V
D
R
M
I
E
E
T
K
K
A
-
D
V
I
L
F
T
G
F
N
R
R
F
D
R
N
F
K
K
L
K
E
A
V
E
N
G
T
I
G
K
--
P
H
V
-
L
R
I
T
-----------
S
-
R
D
----
P
A
--
P
P
--
P
-------
L
D
-
Y
I
------
R
---
V
---
S
--
G
G
I
F
L
D
M
T
I
H
D
F
D
M
-
A
R
Y
I
M
G
----
E
E-
V
E
E
V
F
A
----
D
G
S
V
---
L
V
D
----
E
E
I
G
K
A
G
----------
D
V
--
D
T
A
V
V
V
L
R
F
K
S
G
A
L
G
V
I
---------------
D
N
S
R
R
A
V
Y
G
------------------------------------------
Y
D
Q
--
R
I
E
V
F
--
G
S
--
K
----
G
R
I
F
A
D
N
V
R
-----
E
---
T
---
T
V
V
L
T
-----
D
E
--
Q
---
G
D
----
R
G
S
R
----
Y
---------
L
-
Y
-------
F
F
--
L
E
R
Y
---
R
D
S
---------------
Y
L
E
E
L
-----
K
T
F
I
K
-
N
V
K
-
S
--
G
E
P
--
P
A
V
S
G
E
D
G
K
M
A
L
L
L
G
Y
A
-
A
K
K
S
L
E
E
K
R
S
V
K
-------
L
E
E
V
5
PsiBlast_PDB
81.07
26%
-95
- C1 -
4KOA
1
AFR_RHIME
A:
[2-305]
-------------------------------
I
R
W
G
L
I
G
A
S
T
I
A
R
-
E
-
W
V
I
G
A
--
I
R
-
A
-
A
--
G
-
G
--------
E
V
V
S
V
M
S
---
S
S
A
E
R
G
---
E
A
----
Y
A
A
---
E
N
------
G
I
A
K
-
A
-
V
T
S
V
D
D
L
V
G
D
P
D
V
D
A
V
Y
I
S
T
T
N
E
L
H
H
G
Q
A
L
A
A
I
R
A
G
K
H
V
L
C
E
K
P
L
A
M
N
L
N
D
G
C
E
M
V
L
K
A
C
E
A
-
G
V
V
L
G
T
N
H
H
L
R
N
A
A
T
H
R
A
M
R
E
A
I
A
A
G
R
I
G
R
--
P
I
A
-
A
R
V
F
H
A
V
Y
L
P
PHLQG
W
-
R
L
----
D
K
--
P
----------------------
E
---
A
---
G
--
G
G
V
I
L
D
I
T
V
H
D
A
D
T
-
L
R
F
V
L
N
DDPI
E
--
A
V
A
I
S
H
----
S
A
G
M
---
G
K
E
----
G
----
L
------------
E
--
D
G
V
M
G
V
L
R
F
R
S
G
V
I
A
Q
F
H
D
A
FTTKF
A
E
-----
T
G
L
E
V
H
G
T
A
G
---
S
L
---------------------
I
G
R
--
N
V
M
T
Q
R
P
--
V
--
G
--
T
V
V
L
R
--
N
E
--
E
----
G
E
S
E
L
P
L
D
H
-----
R
---
N
---
L
--
Y
E
-----
T
A
--
I
---
A
A
----
F
H
S
A
----
I
---------
G
-
G
N
------
G
R
--
P
S
A
S
---
G
E
D
---------------
G
V
W
S
L
-----
A
T
G
L
A
-
V
V
K
-
A
--
A
A
T
--
G
G
A
V
E
I
E
T
G
L
-------------------------------
33
HHSearch
81.04
22%
-92
- C1 -
3RC1
7
?
A:
[26-348]
-----------------------------
N
P
I
R
V
G
V
I
G
C
A
D
I
A
W
-
R
R
A
L
P
A
L
--
E
A
-
E
-
P
--
L
-
T
--------
E
V
T
A
I
A
S
---
R
---
R
W
D
R
A
K
R
----
F
T
E
---
R
F
------
G
G
-
E
-
P
-
V
E
G
Y
P
A
L
L
E
R
D
D
V
D
A
V
Y
V
P
L
P
A
V
L
H
A
E
W
I
D
R
A
L
R
A
G
K
H
V
L
A
E
K
P
L
T
T
D
R
P
Q
A
E
R
L
F
A
V
A
R
E
R
-
G
L
L
L
M
E
N
F
M
F
L
H
H
P
Q
H
R
Q
V
A
D
M
L
D
E
G
V
I
G
E
--
I
R
S
-
F
A
A
S
-----------
F
-
T
I
----
P
P
--
K
-----
P
---
Q
-
G
D
-
I
R
---
Y
--
Q
AD-
V
---
G
--
G
G
A
L
L
D
I
G
V
Y
P
I
R
A
-
A
G
L
F
L
G
----
A
D-
L
E
F
V
G
A
----
V
L
R
H
---
E
R
-----
D
----
R
D
----------
V
V
--
V
G
G
N
A
L
L
T
T
R
Q
G
V
T
A
Q
L
---------------
T
F
G
M
E
H
A
--------------------------------------------
Y
T
N
--
N
Y
E
F
R
--
G
S
--
T
----
G
R
L
W
M
N
R
V
F
-----
T
---
P
---
P
--
A
T
Y
----
Q
P
--
V
---
V
H
----
I
E
R
Q
----
D
---------
H
-
A
E
------
Q
F
--
V
L
P
A
---
H
D
Q
---------------
F
A
K
S
I
-----
R
A
F
A
Q
-
A
V
L
-
S
--
G
E
H
--
P
R
E
W
S
E
D
S
L
R
Q
A
S
L
V
D
A
-
V
R
T
G
A
R
D
I
Y
F
P
------------
43
Fugue
80.89
22%
-94
* C1 *
1ZH8
7
?
A:
[16-340]
----------------------------
L
R
K
I
R
L
G
I
V
G
C
G
I
A
A
R
-
E
L
H
L
P
A
L
--
K
N
-
L
-
S
--
H
L
F
--------
E
I
T
A
V
T
S
RT
R
S
---
H
A
---
E
E
----
F
A
K
M
--
V
G
------
N
P
-
A
-
V
-
F
D
S
Y
E
E
L
L
E
S
G
L
V
D
A
V
D
L
T
L
P
V
E
L
N
L
P
F
I
E
K
A
L
R
K
G
V
H
V
I
C
E
K
P
I
S
T
D
V
E
T
G
K
K
V
V
E
L
S
E
K
S
-
E
K
T
V
Y
I
A
E
N
F
R
H
V
P
A
F
W
K
A
K
E
L
V
E
S
G
A
I
G
D
--
P
V
F
M
N
W
Q
I
-----------
W
-
V
G
M---
D
E
--
N
N
--
K
Y
V
---
H
-
T
D
-
W
R
---
K
--
K
---
P
KH-
V
--
G
G
F
L
S
D
G
G
V
H
H
A
A
A
M
R
L
-
I
L
G
----
E
--
I
E
W
I
S
A
----
V
A
K
D
----
L
S
----
P
----
L
L
----------
G
G
M-
D
F
L
S
S
I
F
E
F
E
N
G
T
V
G
N
Y
---------------
T
I
S
------------------------------------------
Y
S
L
--
K
G
N
E
--
R
F
E
I
T
--
G
T
--
K
----
G
K
I
S
I
S
W
D
K
-----
I
---
V
---
L
-------------------------------------------
N
E
------
E
E
M
-
K
V
P
Q
---
E
N
S
---------------
Y
Q
K
E
F
-----
E
D
F
Y
Q
-
V
V
A
E
G
--
K
P
N
--
D
L
G
S
P
V
Q
A
L
K
D
L
A
F
I
E
A
-
C
V
R
S
A
G
N
K
V
F
V
S
-------
S
L
L
-
23
HHSearch
80.88
20%
-89
- C1 -
3CEA
1
?
A:
[5-345]
---------------------------
T
R
K
P
L
R
A
A
I
I
G
L
G
R
L
G
E
-
R
-
H
A
R
H
L
--
V
N
K
I
-
Q
--
G
-
V
--------
K
L
V
A
A
C
A
---
L
---
D
S
N
Q
L
E
W
----
A
K
N
---
E
L
------
G
V
-
E
T
T
-
Y
T
N
Y
K
D
M
I
D
T
E
N
I
D
A
I
F
I
V
A
P
T
P
F
H
P
E
M
T
I
Y
A
M
N
A
G
L
N
V
F
C
E
K
P
L
G
L
D
F
N
E
V
D
E
M
A
K
V
I
K
S
H
P
N
Q
I
F
Q
S
G
F
M
R
R
Y
D
D
S
Y
R
Y
A
K
K
I
V
D
N
G
D
I
G
K
--
I
I
Y
-
M
R
G
Y
-----------
G
-
I
D
----
P
I
--
S
G
--
M
E
S
---
F
-
T
K
-
F
A
---
T
--
E
A--
D
---
S
--
G
G
I
F
V
D
M
N
I
H
D
I
D
L
-
I
R
W
F
T
G
----
Q
D-
P
V
Q
A
Y
G
----
L
T
S
N
---
I
A
A
P
Q
L
A
D
----
I
G
----------
E
F
--
E
T
G
V
A
Q
L
K
M
S
D
G
V
I
A
T
L
---------------
I
G
G
R
H
A
A
H
G
------------------------------------------
N
Q
V
--
E
L
E
V
M
--
G
S
--
N
----
G
W
V
R
I
G
E
H
P
DLNR-
V
---
T
---
V
--
F
N
-----
D
-------
Q
G
----
V
V
R
P
----
S
---------
L
--
Q
------
S
F
--
G
E
R
F
---
D
T
A
---------------
F
T
D
E
V
-----
Q
D
F
V
N
-
N
V
I
-
V
--
G
K
Q
--
P
E
V
T
V
D
D
G
I
K
A
L
K
I
A
K
A
-
C
Q
Q
S
A
N
I
G
K
L
V
D
-------
I
Q
L
-
21
HHSearch
80.85
22%
-97
- C1 -
1ZH8
7
?
A:
[16-337]
----------------------------
L
R
K
I
R
L
G
I
V
G
C
G
I
A
A
R
-
E
L
H
L
P
A
L
--
K
N
-
L
-
S
H-
L
-
F
--------
E
I
T
A
V
T
S
---
R
---
T
R
S
H
A
E
E
----
F
A
K
---
M
V
------
G
N
P
A
-
V
-
F
D
S
Y
E
E
L
L
E
S
G
L
V
D
A
V
D
L
T
L
P
V
E
L
N
L
P
F
I
E
K
A
L
R
K
G
V
H
V
I
C
E
K
P
I
S
T
D
V
E
T
G
K
K
V
V
E
L
S
E
K
S
-
E
K
T
V
Y
I
A
E
N
F
R
H
V
P
A
F
W
K
A
K
E
L
V
E
S
G
A
I
G
D
--
P
V
F
-
M
N
W
Q
-----------
I
-
W
V
----
G
M
--
D
E
NN
K
Y
V
---
H
-
T
D
-
W
R
---
K
--
K
PK-
H
---
V
--
G
G
F
L
S
D
G
G
V
H
H
A
A
A
-
M
R
L
I
L
G
----
E
--
I
E
W
I
S
A
----
V
A
K
D
---
L
S
P
----
L
----
L
G
----------
G
M
--
D
F
L
S
S
I
F
E
F
E
N
G
T
V
G
N
Y
---------------
T
I
S
Y
S
L
K
--------------------------------------------
G
N
E
--
R
F
E
I
T
--
G
T
--
K
----
G
K
I
S
I
S
W
D
K
-----
I
---
V
---
L
--
N
E
-------------
E
E
-------------------------
M
------
K
----
V
P
Q
---
E
N
S
---------------
Y
Q
K
E
F
-----
E
D
F
Y
Q
-
V
V
A
-
E
--
G
K
P
N-
D
L
G
S
P
V
Q
A
L
K
D
L
A
F
I
E
A
-
C
V
R
S
A
G
N
K
V
F
V
S
-------
S
L
L
-
49
Fugue
79.87
21%
-85
- C1 -
3MOI
-
?
A:
[1-387]
-----------------------------
M
K
I
R
F
G
I
C
G
L
G
F
A
G
S
V
L
-
M
A
P
A
M
--
R
H
-
H
-
P
--
D
-
A
--------
Q
I
V
A
A
C
D
---
P
N
E
D
V
R
---
E
R
----
F
G
K
---
E
Y
------
G
I
-
P
-
V
-
F
A
T
L
A
E
M
M
Q
H
V
Q
M
D
A
V
Y
I
A
S
P
H
Q
F
H
C
E
H
V
V
Q
A
S
E
Q
G
L
H
I
I
V
E
K
P
L
T
L
S
R
D
E
A
D
R
M
I
E
A
V
E
R
A
-
G
V
H
L
V
V
G
T
S
R
S
H
D
P
V
V
R
T
L
R
A
I
V
Q
E
G
S
V
G
R
--
V
S
M
-
L
N
C
F
-----------
N
-
Y
------
T
--
D
F
--
L
Y
R
PRR
P
-
E
E
-
L
D
---
T
--
S
---
K
---
G
--
G
G
I
I
Y
N
Q
L
P
H
Q
I
D
S
-
I
K
T
I
T
G
Q---
R
--
I
T
A
V
R
A
----
M
T
G
R
---
L
D
P
----
K
----
R
P
----------
T
E
--
G
N
C
A
A
M
L
T
L
E
D
G
A
C
A
V
M
---------------
V
Y
S
G
Y
D
H
F
D
S
---
D
E
MHFWLAEGGRAKQPNHGG
A
R
K
V
L
R
--
Q
L
E
G
D
E
A
--
E
L
R
R
--
S
R
Y
G
F
--
G
G
--
P
----
I
S
K
S
D
R
K
Q
P
-----
H
---
F
---
G
--
V
M
-----
L
V
--
T
---
C
E
----
H
A
D
L
----
R
---------
A
-
S
P
------
E
G
--
V
L
V
Y
---
G
D
E
G
V
R
E
V
P
A
ITGRGPF
S
Q
G
D
T
I
-----
D
E
L
R
D
-
A
I
A
-
G
--
V
A
P
--
A
L
R
D
A
R
W
G
K
D
T
L
E
V
C
L
A
-
V
L
E
S
S
A
T
G
R
Q
V
E
-------
R
---
30
HHSearch
79.12
23%
-91
- C1 -
3OHS
10
DHDH_MACFA
X:
[2-332]
------------------------------
A
L
R
W
G
I
V
S
V
G
L
I
S
S
-
D
-
F
T
A
V
L
--
Q
T
-
L
-
P
RS
E
-
H
--------
Q
V
V
A
V
A
A
---
R
---
D
L
SRA
K
E
----
F
A
Q
---
K
H
------
D
I
-
P
K
A
-
Y
G
S
Y
E
E
L
A
K
D
P
N
V
E
V
A
Y
V
G
T
Q
H
P
Q
H
K
A
A
V
M
L
C
L
A
A
G
K
A
V
L
C
E
K
P
M
G
V
N
A
A
E
V
R
E
M
V
T
E
A
R
S
R
-
G
L
F
L
M
E
A
I
W
T
R
F
F
P
A
S
E
A
L
R
S
V
L
A
Q
G
T
L
G
D
--
L
R
V
-
A
R
A
E
-----------
F
-
G
K
----
N
L
--
T
H
--
V
P
R
---
A
-
V
D
-
W
A
----------
Q
---
A
--
G
G
A
L
L
D
L
G
I
Y
C
V
Q
F
-
I
S
M
V
F
G
----
G
QK
P
E
K
I
S
V
----
M
G
R
R
---
H
E
T
----------
G
----------
V
D
--
D
T
V
T
V
L
L
Q
Y
P
G
E
V
H
G
S
F
---------------
T
C
S
I
T
A
Q
L
--------------------------------------------
S
N
--
T
A
S
V
S
--
G
T
--
K
----
G
M
A
Q
L
L
N
P
C
WCPTE
L
---
V
---
V
--
K
G
-----
E
---
H
---
K
E
----
F
L
L
P
----
P
---------
V
-
P
K
------
N
C
--
N
F
D
N
---
G
A
G
---------------
M
S
Y
E
A
-----
K
H
V
R
E
-
C
L
R
-
K
--
G
L
K
ES
P
V
I
P
L
V
E
S
E
L
L
A
D
I
L
E
E
-
V
R
R
A
I
G
V
T
F
P
Q
D
-----------
46
Fugue
78.55
21%
-90
- C1 -
1OFG
2
GFO_ZYMMO
A:
[1-381]
ATLP
A
G
A
S
Q
VPT
T
P
A
G
R
P
MPYAI
R
P
M
P
E
D
R
R
F
G
Y
A
I
V
G
L
G
K
Y
A
L
-
N
-
Q
I
L
P
G
FA-
G
-
C
-
Q
--
H
-
S
--------
R
I
E
A
L
V
S
---
G
N
A
E
K
A
---
K
I
----
V
A
A
---
E
-
Y
GVDPR
K
I
-
Y
-
D
-
Y
S
N
F
D
K
I
A
K
D
P
K
I
D
A
V
Y
I
I
L
P
N
S
L
H
A
E
F
A
I
R
A
F
K
A
G
K
H
V
M
C
E
K
P
M
A
T
S
V
A
D
C
Q
R
M
I
D
A
A
K
A
A
-
N
K
K
L
M
I
G
Y
R
C
H
Y
D
P
M
N
R
A
A
V
K
L
I
R
E
N
Q
L
G
K
--
L
G
M
-
V
T
T
D
-----------
N
-
S
D
----
V
M
--
D
Q
--
N
D
P
---
A
-
Q
Q
-
W
R
LRR
E
--
L
---
A
---
G
--
G
G
S
L
M
D
I
G
I
Y
G
L
N
G
-
T
R
Y
L
L
G
E---
E
--
P
I
E
V
R
A
----
Y
T
Y
S
DPN
D
E
R
----
F
----
V
E
----------
V
E
--
D
R
I
I
W
Q
M
R
F
R
S
G
A
L
S
H
G
---------------
A
S
S
Y
S
------------------------------------------
T
--
T
T
T
S
--
R
F
S
V
Q
--
G
D
--
K
----
A
V
L
L
M
D
P
A
T
-----
G
---
Y
---
Y
--
Q
N
-----
L
I
--
S
---
V
Q
T
PG
H
A
N
Q
S
----
M
---------
M
-
P
Q
------
F
I
--
M
P
A
N
----
N
Q
---------------
F
S
A
Q
L
-----
D
H
L
A
E
-
A
V
I
-
N
NK--
P
--
V
R
S
P
G
E
E
G
M
Q
D
V
R
L
I
Q
A
-
I
Y
E
A
A
R
T
G
R
P
V
N
TDWG
Y
V
R
Q
G
G
Y
24
HHSearch
77.87
21%
-85
- C1 -
3EUW
1
?
A:
[3-334]
-----------------------------
L
T
L
R
I
A
L
F
G
A
G
R
I
G
H
-
V
-
H
A
A
N
I
--
A
A
-
N
-
P
--
D
-
L
--------
E
L
V
V
I
A
D
---
P
---
F
I
E
G
A
Q
R
----
L
A
E
---
A
N
------
G
A
-
E
-
A
-
V
A
S
P
D
E
V
F
A
R
D
D
I
D
G
I
V
I
G
S
P
T
S
T
H
V
D
L
I
T
R
A
V
E
R
G
I
P
A
L
C
E
K
P
I
D
L
D
I
E
M
V
R
A
C
K
E
K
I
G
D
G
-
A
S
K
V
M
L
G
F
N
R
R
F
D
P
S
F
A
A
I
N
A
R
V
A
N
Q
E
I
G
N
--
L
E
Q
-
L
V
I
I
-----------
S
-
R
D
----
P
A
--
P
-----
A
---
P
-
K
D
-
Y
I
------
A
---
G
---
S
--
G
G
I
F
R
D
M
T
I
H
D
L
D
M
-
A
R
F
F
V
P
----
N
--
I
V
E
V
T
A
----
T
G
A
N
---
V
F
S
Q
E
I
A
E
----
F
N
----------
D
Y
--
D
Q
V
I
V
T
L
R
G
S
K
G
E
L
I
N
I
---------------
V
N
S
R
H
C
S
Y
G
------------------------------------------
Y
D
Q
--
R
L
E
A
F
--
G
S
--
K
----
G
M
L
A
A
D
N
I
R
-----
P
---
T
T
V
R
K
--
H
N
-----
A
E
--
S
---
T
E
----
Q
A
D
P
----
I
---------
F
-
N
F
------
F
L
---
E
R
Y
---
D
A
A
---------------
Y
K
A
E
L
-----
A
T
F
A
Q
-
G
I
R
-
D
--
G
Q
G
--
F
S
P
N
F
E
D
G
V
I
A
L
E
L
A
N
A
-
C
L
E
S
A
Q
T
G
R
T
V
T
-------
L
N
P
A
6
PsiBlast_PDB
77.29
25%
-85
- C1 -
2GLX
2
AFR_ENSAD
A:
[2-304]
--------------------------------
R
W
G
L
I
G
A
S
T
I
A
R
-
E
-
W
V
I
G
A
--
I
R
-
A
-
T
--
G
-
G
--------
E
V
V
S
M
M
S
---
T
S
A
E
R
G
---
A
A
----
Y
A
T
---
E
N
------
G
I
G
K
-
S
-
V
T
S
V
E
E
L
V
G
D
P
D
V
D
A
V
Y
V
S
T
T
N
E
L
H
R
E
Q
T
L
A
A
I
R
A
G
K
H
V
L
C
E
K
P
L
A
M
T
L
E
D
A
R
E
M
V
V
A
A
R
E
A
-
G
V
V
L
G
T
N
H
H
L
R
N
A
A
A
H
R
A
M
R
D
A
I
A
E
G
R
I
G
R
--
P
I
A
-
A
R
V
F
H
A
V
Y
LPPHLQG
W
-
R
L
----
E
R
--
P
----------------------
E
---
A
---
G
--
G
G
V
I
L
D
I
T
V
H
D
A
D
T
-
L
R
F
V
L
N
D
D
P
A
E
--
A
V
A
I
S
H
----
S
A
G
M
---
G
K
E
----
G
----
V
------------
E
--
D
G
V
M
G
V
L
R
F
Q
S
G
V
I
A
Q
F
H
--------------
D
A
F
T
T
K
F
A
E
T
---
G
F
------------------
E
V
H
G
T
E
--
G
S
L
I
G
R
N
VM
T
Q
K
P
V
G
T
V
T
L
R
--
N
A
--
E
----
G
E
S
Q
L
P
L
D
P
-----
A
---
N
---
L
--
Y
E
-----
T
A
--
L
---
A
A
----
F
H
S
A
----
I
---------
E
-
G
H
------
G
Q
--
P
S
A
T
---
G
E
D
---------------
G
V
W
S
L
-----
A
T
G
L
A
-
V
V
K
-
A
--
A
A
T
--
G
Q
A
A
E
I
E
T
G
L
-------------------------------
3
PsiBlast_PDB
75.60
25%
-94
- C1 -
3EZY
2
?
A:
[3-301]
-------------------------------
L
R
I
G
V
I
G
L
G
R
I
G
T
-
I
-
H
A
E
N
L
--
K
M
-
I
-
D
--
D
-
A
--------
I
L
Y
A
I
S
D
---
V
---
R
E
D
R
L
R
E
----
M
K
E
---
K
L
------
G
V
-
E
-
K
A
Y
K
D
P
H
E
L
I
E
D
P
N
V
D
A
V
L
V
C
S
S
T
N
T
H
S
E
L
V
I
A
C
A
K
A
K
K
H
V
F
C
E
K
P
L
S
L
N
L
A
D
V
D
R
M
I
E
E
T
K
K
A
-
D
V
I
L
F
T
G
F
N
R
R
F
D
R
N
F
K
K
L
K
E
A
V
E
N
G
T
I
G
K
PH
V
L
R
-
I
T
S
R
-----------
D
-
P
A
----
P
P
--
P
L
--
D
Y
I
---
R
-
V
S
--------------------
G
G
I
F
L
D
M
T
I
H
D
F
D
M
-
A
R
Y
I
M
G
E---
E
--
V
E
E
V
F
A
D
G
S
V
L
V
D
E
---
E
I
G
----
K
----
A
G
----------
D
V
--
D
T
A
V
V
V
L
R
F
K
S
G
A
L
G
V
I
---------------
D
N
S
R
R
A
V
Y
G
Y
---
D
Q
R
I
----------------
E
V
F
G
S
K
--
G
R
I
F
A
D
N
--
V
R
E
T
--
T
V
V
L
T
--
D
E
--
Q
----
G
D
R
G
S
R
Y
L
Y
-----
F
---
F
LE-
R
--
Y
----------
R
---
D
S
----
Y
L
E
E
----
L
---------
K
-
T
F
------
I
K
--
N
V
K
S
---
G
E
P
---------------
P
A
V
S
G
-----
E
D
G
K
M
-
A
L
L
-
L
--
G
Y
A
--
A
K
K
S
L
E
E
K
R
S
V
K
L
E
E
V
I
------------------------
18
PsiBlast_PDB
73.21
28%
-109
- C1 -
4GQA
-
?
A:
[25-309]
-----------------------------
A
R
L
N
I
G
L
I
G
S
G
F
M
G
Q
-
A
-
H
A
D
A
Y
--
R
R
-
A
-
A
--
M
-
F
Y
PDLP
K
R
P
H
L
Y
A
L
A
D
-------
Q
D
---
Q
A
M
A
E
R
H
A
A
---
K
L
------
G
A
-
E
-
K
A
Y
G
D
W
R
E
L
V
N
D
P
Q
V
D
V
V
D
I
T
S
P
N
H
L
H
Y
T
M
A
M
A
A
I
A
A
G
K
H
V
Y
C
E
K
P
L
A
V
N
E
Q
Q
A
Q
E
M
A
Q
A
A
R
R
A
-
G
V
K
T
M
V
A
F
N
N
I
K
T
P
A
A
L
L
A
K
Q
I
I
A
R
G
D
I
G
E
--
P
V
R
-
F
R
G
T
-----------
F
D
Q
G
----
F
Y
--
N
D
--
P
N
L
---
P
-
W
S
-
W
R
---
C
--
S
---
K
TLG
G
--
S
G
A
L
G
D
L
G
A
H
T
L
S
V
-
A
Q
F
L
L
G
----
G
--
I
R
E
V
T
A
----
S
A
Q
T
---
C
L
R
----
Q
----
R
P
V
PD
A
E
W
R
E
VE
N
D
--
D
Q
V
Q
C
L
V
N
F
D
S
G
A
A
G
V
I
---------------
E
A
S
R
I
A
A
G
R
I
FG
V
F
W
------------------
E
V
S
G
T
E
--
G
T
L
Y
M
D
G
--
E
R
F
N
--
E
L
Q
V
Y
--
R
F
--
N
----
D
D
K
H
D
R
G
F
K
-----
T
---
L
---
Y
--
A
G
-----
S
Q
--
I
---
P
A
----
Y
A
G
F
----
F
---------
G
-
F
D
------
F
G
--
G
G
G
L
---
G
Y
F
---------------
D
V
K
V
I
-----
E
V
H
D
L
-
V
Q
G
-
I
--
C
G
D
--
D
D
C
Y
P
N
F
E
F
G
L
Q
N
Q
R
V
L
-
S
A
I
E
A
S
M
V
S
R
R
W
-------
V
N
V
V